Center for Integrated Medical Research

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2020

Factors influencing vehicle passenger fatality have changed over 10 years: a nationwide hospital-based study

Ishii, W., Hitosugi, M., Takeda, A., Baba, M. & Iizuka, R., 2020 Dec 1, In : Scientific reports. 10, 1, 3316.

Research output: Contribution to journalArticle

Open Access
2019

Influence of workplace environment, working conditions and health status of taxi drivers on vehicle collisions or near-miss events

Baba, M., Miyama, G., Sugiyama, D. & Hitosugi, M., 2019 Jan 1, In : Industrial Health. 57, 4, p. 530-536 7 p.

Research output: Contribution to journalArticle

Open Access

Innervation of the tibial epiphysis through the intercondylar foramen

Matsuo, K., Ji, S., Miya, A., Yoda, M., Hamada, Y., Tanaka, T., Takao-Kawabata, R., Kawaai, K., Kuroda, Y. & Shibata, S., 2019 Mar 1, In : Bone. 120, p. 297-304 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Trans-pairing between osteoclasts and osteoblasts shapes the cranial base during development

Edamoto, M., Kuroda, Y., Yoda, M., Kawaai, K. & Matsuo, K., 2019 Dec 1, In : Scientific Reports. 9, 1, 1956.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Granulocyte-colony stimulating factor enhances load-induced muscle hypertrophy in mice

Ohashi, M., Okubo, K., Mizuno, S., Yoda, M., Shirasawa, H., Chiba, K., Horiuchi, K., Matsumoto, M. & Nakamura, M., 2018 Jan 1, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

Inhibition of ADAM10 in satellite cells accelerates muscle regeneration following muscle injury

Mizuno, S., Yoda, M., Shimoda, M., Chiba, K., Nakamura, M. & Horiuchi, K., 2018 Jan 1, (Accepted/In press) In : Journal of Orthopaedic Research.

Research output: Contribution to journalArticle

Targeted ablation of p38α MAPK suppresses denervation-induced muscle atrophy

Yuasa, K., Okubo, K., Yoda, M., Otsu, K., Ishii, Y., Nakamura, M., Itoh, Y. & Horiuchi, K., 2018 Dec 1, In : Scientific reports. 8, 1, 9037.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2017

Inhibition of PDGFR signaling prevents muscular fatty infiltration after rotator cuff tear in mice

Shirasawa, H., Matsumura, N., Shimoda, M., Oki, S., Yoda, M., Tohmonda, T., Kanai, Y., Matsumoto, M., Nakamura, M. & Horiuchi, K., 2017 Jan 31, In : Scientific Reports. 7, 41552.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Splicing variation of Long-IRBIT determines the target selectivity of IRBIT family proteins

Kawaai, K., Ando, H., Satoh, N., Yamada, H., Ogawa, N., Hirose, M., Mizutani, A., Bonneau, B., Seki, G. & Mikoshiba, K., 2017 Apr 11, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 15, p. 3921-3926 6 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)
2016

Conditional abrogation of Atm in osteoclasts extends osteoclast lifespan and results in reduced bone mass

Hirozane, T., Tohmonda, T., Yoda, M., Shimoda, M., Kanai, Y., Matsumoto, M., Morioka, H., Nakamura, M. & Horiuchi, K., 2016 Sep 28, In : Scientific Reports. 6, 34426.

Research output: Contribution to journalArticle

3 Citations (Scopus)

IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact

Bonneau, B., Ando, H., Kawaai, K., Hirose, M., Takahashi-Iwanaga, H. & Mikoshiba, K., 2016 Dec 20, In : eLife. 5, DECEMBER2016, e19896.

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)
2015

ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface

Uchikawa, S., Yoda, M., Tohmonda, T., Kanaji, A., Matsumoto, M., Toyama, Y. & Horiuchi, K., 2015 Feb 1, In : Cytokine. 71, 2, p. 238-245 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

A disintegrin and metalloprotease 10 (ADAM10) is indispensable for maintenance of the muscle satellite cell pool

Mizuno, S., Yoda, M., Shimoda, M., Tohmonda, T., Okada, Y., Toyama, Y., Takeda, SI., Nakamura, M., Matsumoto, M. & Horiuchi, K., 2015 Nov 20, In : Journal of Biological Chemistry. 290, 47, p. 28456-28464 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Generation and characterization of a novel shoulder contracture mouse model

Oki, S., Shirasawa, H., Yoda, M., Matsumura, N., Tohmonda, T., Yuasa, K., Nakamura, M., Matsumoto, M. & Horiuchi, K., 2015 Nov 1, In : Journal of Orthopaedic Research. 33, 11, p. 1732-1738 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

IRBIT interacts with the catalytic core of phosphatidylinositol phosphate kinase type Ia and IIa through conserved catalytic aspartate residues

Ando, H., Hirose, M., Gainche, L., Kawaai, K., Bonneau, B., Ijuin, T., Itoh, T., Takenawa, T. & Mikoshiba, K., 2015 Oct 28, In : PloS one. 10, 10, 0141569.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

IRBIT regulates CaMKIIα activity and contributes to catecholamine homeostasis through tyrosine hydroxylase phosphorylation

Kawaai, K., Mizutani, A., Shoji, H., Ogawa, N., Ebisui, E., Kuroda, Y., Wakana, S., Miyakawa, T., Hisatsune, C. & Mikoshiba, K., 2015 Apr 28, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 17, p. 5515-5520 6 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis

Tohmonda, T., Yoda, M., Iwawaki, T., Matsumoto, M., Nakamura, M., Mikoshiba, K., Toyama, Y. & Horiuchi, K., 2015 Aug 3, In : Journal of Clinical Investigation. 125, 8, p. 3269-3279 11 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2013

Conditional Inactivation of TNFα-Converting Enzyme in Chondrocytes Results in an Elongated Growth Plate and Shorter Long Bones

Saito, K., Horiuchi, K., Kimura, T., Mizuno, S., Yoda, M., Morioka, H., Akiyama, H., Threadgill, D., Okada, Y., Toyama, Y. & Sato, K., 2013 Jan 18, In : PloS one. 8, 1, e54853.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Irbit mediates synergy between Ca2+ and cAMP signaling pathways during epithelial transport in mice

Park, S., Shcheynikov, N., Hong, J. H., Zheng, C., Suh, S. H., Kawaai, K., Ando, H., Mizutani, A., Abe, T., Kiyonari, H., Seki, G., Yule, D., Mikoshiba, K. & Muallem, S., 2013 Jul, In : Gastroenterology. 145, 1, p. 232-241 10 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Systemic Overexpression of TNFα-converting Enzyme Does Not Lead to Enhanced Shedding Activity In Vivo

Yoda, M., Kimura, T., Tohmonda, T., Morioka, H., Matsumoto, M., Okada, Y., Toyama, Y. & Horiuchi, K., 2013 Jan 14, In : PloS one. 8, 1, e54412.

Research output: Contribution to journalArticle

26 Citations (Scopus)

The IRE1α-XBP1 pathway positively regulates parathyroid hormone (PTH)/PTH-related peptide receptor expression and is involved in PTH-induced osteoclastogenesis

Tohmonda, T., Yoda, M., Mizuochi, H., Morioka, H., Matsumoto, M., Urano, F., Toyama, Y. & Horiuchi, K., 2013 Jan 18, In : Journal of Biological Chemistry. 288, 3, p. 1691-1695 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2012

A novel multi-kinase inhibitor pazopanib suppresses growth of synovial sarcoma cells through inhibition of the PI3K-AKT pathway

Hosaka, S., Horiuchi, K., Yoda, M., Nakayama, R., Tohmonda, T., Susa, M., Nakamura, M., Chiba, K., Toyama, Y. & Morioka, H., 2012 Sep 1, In : Journal of Orthopaedic Research. 30, 9, p. 1493-1498 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

The transient appearance of zipper-like actin superstructures during the fusion of osteoclasts

Takito, J., Nakamura, M., Yoda, M., Tohmonda, T., Uchikawa, S., Horiuchi, K., Toyama, Y. & Chiba, K., 2012 Feb 1, In : Journal of Cell Science. 125, 3, p. 662-672 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2011

Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoiesis

Yoda, M., Kimura, T., Tohmonda, T., Uchikawa, S., Koba, T., Takito, J., Morioka, H., Matsumoto, M., Link, D. C., Chiba, K., Okada, Y., Toyama, Y. & Horiuchi, K., 2011 Dec 22, In : Blood. 118, 26, p. 6939-6942 4 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

The IRE1α-XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix

Tohmonda, T., Miyauchi, Y., Ghosh, R., Yoda, M., Uchikawa, S., Takito, J., Morioka, H., Nakamura, M., Iwawaki, T., Chiba, K., Toyama, Y., Urano, F. & Horiuchi, K., 2011 May 1, In : EMBO Reports. 12, 5, p. 451-457 7 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)
2010

GRIP1 enhances estrogen receptor α-dependent extracellular matrix gene expression in chondrogenic cells

Kato, M., Takaishi, H., Yoda, M., Tohmonda, T., Takito, J., Fujita, N., Hosogane, N., Horiuchi, K., Kimura, T., Okada, Y., Saito, T., Kawaguchi, H., Kikuchi, T., Matsumoto, M., Toyama, Y. & Chiba, K., 2010 Jul 1, In : Osteoarthritis and Cartilage. 18, 7, p. 934-941 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Inhibition of STAT1 accelerates bone fracture healing

Tajima, K., Takaishi, H., Takito, J., Tohmonda, T., Yoda, M., Ota, N., Kosaki, N., Matsumoto, M., Ikegami, H., Nakamura, T., Kimura, T., Okada, Y., Horiuchi, K., Chiba, K. & Toyama, Y., 2010 Jul 1, In : Journal of Orthopaedic Research. 28, 7, p. 937-941 5 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Receptor activator of NF-κB (RANK) ligand induces ectodomain shedding of RANK in murine RAW264.7 macrophages

Hakozaki, A., Yoda, M., Tohmonda, T., Furukawa, M., Hikata, T., Uchikawa, S., Takaishi, H., Matsumoto, M., Chiba, K., Horiuchi, K. & Toyama, Y., 2010 Mar 1, In : Journal of Immunology. 184, 5, p. 2442-2448 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2009

80K-H interacts with inositol 1,4,5-trisphosphate (IP 3) receptors and regulates IP 3-induced calcium release activity

Kawaai, K., Hisatsune, C., Kuroda, Y., Mizutani, A., Tashiro, T. & Mikoshiba, K., 2009 Jan 2, In : Journal of Biological Chemistry. 284, 1, p. 372-380 9 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Accelerated cartilage resorption by chondroclasts during bone fracture healing in osteoprotegerin-deficient mice

Ota, N., Takaishi, H., Kosaki, N., Takito, J., Yoda, M., Tohmonda, T., Kimura, T., Okada, Y., Yasuda, H., Kawaguchi, H., Matsumoto, M., Chiba, K., Ikegami, H. & Toyama, Y., 2009 Nov 1, In : Endocrinology. 150, 11, p. 4823-4834 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

IL-27 abrogates receptor activator of NF-κB ligand-mediated osteoclastogenesis of human granulocyte-macrophage colony-forming unit cells through STAT1-dependent inhibition of c-Fos

Furukawa, M., Takaishi, H., Takito, J., Yoda, M., Sakai, S., Hikata, T., Hakozaki, A., Uchikawa, S., Matsumoto, M., Chiba, K., Kimura, T., Okada, Y., Matsuo, K., Yoshida, H. & Toyama, Y., 2009 Aug 15, In : Journal of Immunology. 183, 4, p. 2397-2406 10 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2006

Differences in integrin-dependent phagocytosis among three hemocyte subpopulations of the Pacific oyster "Crassostrea gigas"

Terahara, K., Takahashi, K. G., Nakamura, A., Osada, M., Yoda, M., Hiroi, T., Hirasawa, M. & Mori, K., 2006 Apr 25, In : Developmental and Comparative Immunology. 30, 8, p. 667-683 17 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
2002

Detection of stimulants from charred bodies killed by a traffic accident: Distribution in the bodies

Nakajima, R., Shinozuka, T., Takei, S., Ohue, O., Baba, M., Ro, A., Yanagida, J. & Murai, T., 2002 Jan 1, In : Japanese Journal of Forensic Toxicology. 20, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

Telomerase activity detected in eyed embryos of rainbow trout Oncorhynchus mykiss

Yoda, M., Takahashi, K. G. & Mori, K., 2002 Mar 20, In : Fisheries Science. 68, 1, p. 132-137 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)