Department of Biosciences and Informatics

Research Output 1987 2020

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1987
2 Citations (Scopus)

Effects of external Ca2+ on K+ permeability of the elongating region of mung bean roots under high KCl stress

Oka, K., Ishikawa, H., Ohta, E. & Sakata, M., 1987 Jun, In : Plant and Cell Physiology. 28, 4, p. 581-586 6 p.

Research output: Contribution to journalArticle

Mung Bean
Ethylenediaminetetraacetic acid
Cell membranes
mung beans
Permeability
5 Citations (Scopus)

Membrane potential measurement of protoplasts isolated from vigna mungo hypocotyl using a fluorescent probe, diS-C3-(5)

Oka, K., Naitou, S., Yoshida, M., Ishikawa, H., Ohta, E. & Sakata, M., 1987 Jul, In : Plant and Cell Physiology. 28, 5, p. 843-849 7 p.

Research output: Contribution to journalArticle

Hypocotyl
Protoplast
Vigna mungo
Membrane Potential
Protoplasts
1988

Asymmetric Hydrolysis of 1-Cyanoalkyl Acetates

Ohta, H., Hiraga, S., Miyamoto, K. & Tsuchihashi, G. I., 1988, In : Agricultural and Biological Chemistry. 52, 12, p. 3023-3027 5 p.

Research output: Contribution to journalArticle

Hydrolysis
Acetates
hydrolysis
acetates
Candida tropicalis
20 Citations (Scopus)

Asymmetric hydrolysis of l-Cyanoalkyl acetates

Ohta, H., Hiraga, S., Miyamoto, K. & Tsuchihashi, G. I., 1988, In : Agricultural and Biological Chemistry. 52, 12, p. 3023-3027 5 p.

Research output: Contribution to journalArticle

Hydrolysis
Acetates
hydrolysis
acetates
Candida tropicalis
14 Citations (Scopus)

Surface charge density estimation of vigna mungo protoplasts using a fluorescent dye, 9-aminoacridine

Oka, K., Ikeshima, H., Ishikawa, H., Ohta, E. & Sakata, M., 1988 Jul, In : Plant and Cell Physiology. 29, 5, p. 771-775 5 p.

Research output: Contribution to journalArticle

Aminacrine
Protoplast
Vigna mungo
Protoplasts
fluorescent dyes
1990
84 Citations (Scopus)

Enzyme-mediated asymmetric decarboxylation of disubstituted malonic acids

Miyamoto, K. & Ohta, H., 1990 May 9, In : Journal of the American Chemical Society. 112, 10, p. 4077-4078 2 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Inhibition of EGF-induced phospholipase C activation in A341 cells by erbstatin, a tyrosine kinase inhibitor

Imoto, M., Shimura, N., Hideaki, U. & Umezawa, K., 1990 Nov 30, In : Biochemical and Biophysical Research Communications. 173, 1, p. 208-211 4 p.

Research output: Contribution to journalArticle

Type C Phospholipases
Epidermal Growth Factor
Protein-Tyrosine Kinases
Inositol Phosphates
Chemical activation
127 Citations (Scopus)

Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors

Umezawa, K., Hori, T., Tajima, H., Imoto, M., Isshiki, K. & Takeuchi, T., 1990, In : FEBS Letters. 260, 2, p. 198-200 3 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor
Protein-Tyrosine Kinases
S Phase
Epidermal Growth Factor Receptor
DNA
12 Citations (Scopus)

Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors

Umezawa, K., Hori, T., Tajima, H., Imoto, M., Isshiki, K. & Takeuchi, T., 1990 Jan 29, In : FEBS Letters. 260, 2, p. 201-205 5 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor
Protein-Tyrosine Kinases
S Phase
Epidermal Growth Factor Receptor
DNA
26 Citations (Scopus)

Inhibition of phosphatidylinositol kinase by toyocamycin

Nishioka, H., Sawa, T., Hamada, M., Shimura, N., Imoto, M. & Umezawa, K., 1990, In : Journal of Antibiotics. 43, 12, p. 1586-1589 4 p.

Research output: Contribution to journalArticle

Toyocamycin
Phosphatidylinositols
Phosphotransferases
Enzymes
Nucleosides
1991
39 Citations (Scopus)

Asymmetric decarboxylation of disubstituted malonic acid by alcaligenes bronchisepticus KU 1201

Miyamoto, K. & Ohta, H., 1991, In : Biocatalysis and Biotransformation. 5, 1, p. 49-60 12 p.

Research output: Contribution to journalArticle

Alcaligenes
Decarboxylation
Acids
Microorganisms
Substrates
16 Citations (Scopus)

Induction of morphological change by tyrosine kinase inhibitors in Rous sarcoma virus-transformed rat kidney cells

Umezawa, K., Tanaka, K., Hori, T., Abe, S., Sekizawa, R. & Imoto, M., 1991 Feb 11, In : FEBS Letters. 279, 1, p. 132-136 5 p.

Research output: Contribution to journalArticle

Rous sarcoma virus
Viruses
Protein-Tyrosine Kinases
Rats
Kidney
7 Citations (Scopus)

Inhibition of epidermal growth factor-induced activation of phospholipase C by PSI-tectorigenin [4]

Imoto, M., Shimura, N. & Umezawa, K., 1991, In : Journal of Antibiotics. 44, 8, p. 915-917 3 p.

Research output: Contribution to journalArticle

Isoflavones
Phospholipases
Type C Phospholipases
Epidermal Growth Factor
psi-tectorigenin
1992
2 Citations (Scopus)

Biosynthetic preparation of radioactively labeled erbstatin [1]

Tabata, Y., Imoto, M. & Umezawa, K., 1992, In : Journal of Antibiotics. 45, 8, p. 1382-1384 3 p.

Research output: Contribution to journalArticle

Carbon Radioisotopes
Hydroquinones
Tritium
Streptomyces
Protein-Tyrosine Kinases
29 Citations (Scopus)
Alcaligenes
Cloning
Amino acids
Organism Cloning
DNA
24 Citations (Scopus)
Mandelic Acids
Bacteria
Soil
Methylmalonic Acid
Soils
44 Citations (Scopus)

Highly efficient conversion of (±)-mandelic acid to its (R)-(-)-enantiomer by combination of enzyme-mediated oxidation and reduction

Tsuchiya, S., Miyamoto, K. & Ohta, H., 1992 Dec, In : Biotechnology Letters. 14, 12, p. 1137-1142 6 p.

Research output: Contribution to journalArticle

Enantiomers
Oxidation-Reduction
Enzymes
Oxidation
Acids
22 Citations (Scopus)

Inhibition of CDP-DG: iNositol transferase by inostamycin

Imoto, M., Taniguchi, Y. & Umezawa, K., 1992 Aug, In : Journal of Biochemistry. 112, 2, p. 299-302 4 p.

Research output: Contribution to journalArticle

CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase
Cell membranes
Metabolites
Phosphatidylinositols
Phosphates
10 Citations (Scopus)

Inhibition of tyrosine kinase and src oncogene functions by stable erbstatin analogues

Hori, T., Kondo, T., Tsuji, T., Imoto, M. & Umezawa, K., 1992, In : Journal of Antibiotics. 45, 2, p. 280-282 3 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Microbial asymmetric decarboxylation of fluorine-containing arylmalonic acid derivatives

Miyamoto, K., Tsuchiya, S. & Ohta, H., 1992, In : Journal of Fluorine Chemistry. 59, 2, p. 225-232 8 p.

Research output: Contribution to journalArticle

Alcaligenes
decarboxylation
Decarboxylation
Fluorine
fluorine
50 Citations (Scopus)
Alcaligenes
Purification
Enzymes
Decarboxylation
Carboxy-Lyases
33 Citations (Scopus)

Stereochemistry of Enzyme-Catalyzed Decarboxylation of α-Methyl-α-phenylmalonic Acid

Miyamoto, K., Tsuchiya, S. & Ohta, H., 1992 Jul 1, In : Journal of the American Chemical Society. 114, 15, p. 6256-6257 2 p.

Research output: Contribution to journalArticle

Stereochemistry
Decarboxylation
Enzymes
Acids
phenylmalonic acid
1993
30 Citations (Scopus)

Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. II. Structure determination

Kakeya, H., Imoto, M., Takahashi, Y., Naganawa, H., Takeuchi, T. & Umezawa, K., 1993, In : Journal of Antibiotics. 46, 11, p. 1716-1719 4 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Streptomyces
Phosphoric Monoester Hydrolases
Tyrosine
dephostatin
83 Citations (Scopus)

Dephostatin, A Novel Protein Tyrosine Phosphatase Inhibitor Produced By Streptomyces I Taxonomy, Isolation, And Characterization

Imoto, M., Hldeaki, K., Tsutomu, S., Cfflgusa, H., Masa, H., Tomio, T. & Kazuo, U., 1993, In : the journal of antibiotics. 46, 9, p. 1342-1346 5 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia

Hiramatsu, T., Imoto, M., Koyano, T. & Umezawa, K., 1993 Sep 30, In : Cancer Letters. 73, 2-3, p. 161-166 6 p.

Research output: Contribution to journalArticle

Morinda
Phenotype
src Genes
Anthraquinones
Plant Extracts
8 Citations (Scopus)

Involvement of tyrosine kinase in growth factor-induced phospholipase C activation in NIH3T3 cells

Imoto, M., Sujikai, I., Ui, H. & Umezawa, K., 1993 Feb 24, In : Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism. 1166, 2-3, p. 188-192 5 p.

Research output: Contribution to journalArticle

Bombesin
Type C Phospholipases
Protein-Tyrosine Kinases
Platelet-Derived Growth Factor
Intercellular Signaling Peptides and Proteins
27 Citations (Scopus)

Isolation of a novel substrate-competitive tyrosine kinase inhibitor, desmal, from the plant Desmos chinensis

Kakeya, H., Imoto, M., Tabata, Y., Iwami, J., Matsumoto, H., Nakamura, K., Koyano, T., Tadano, K. I. & Umezawa, K., 1993 Apr 5, In : FEBS Letters. 320, 2, p. 169-172 4 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Substrates
Inositol Phosphates
X ray crystallography
X Ray Crystallography
1994
14 Citations (Scopus)

Antitumor effect of piericidin B1 N-oxide

Nishioka, H., Imoto, M., Imaoka, T., Imoto, M., Takeuchi, T. & Umezawa, K., 1994, In : Journal of Antibiotics. 47, 4, p. 447-452 6 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Phosphatidic Acids
Streptomyces
Growth
Intraperitoneal Injections
13 Citations (Scopus)

Effect of conformation of the substrate on enzymatic eecarboxylation of α-Arylmalonic Acid

Miyamoto, K., Ohta, H. & Osamura, Y., 1994, In : Bioorganic and Medicinal Chemistry. 2, 6, p. 469-475 7 p.

Research output: Contribution to journalArticle

Conformations
Acids
Substrates
Enzymes
Potential energy surfaces
8 Citations (Scopus)

Enhancement of CDP-DG: inositol transferase activity in src- and erbB2- transformed cells

Imoto, M., Taniguchi, Y., Fujiwara, H. & Umezawa, K., 1994, In : Experimental Cell Research. 212, 1, p. 151-154 4 p.

Research output: Contribution to journalArticle

CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase
Phosphatidylinositols
Protein-Tyrosine Kinases
Rous sarcoma virus
Type C Phospholipases
9 Citations (Scopus)

Induction of Apoptosis by Erbstatin in Mouse Leukemia L1210 Cells

Simizu, S., Imoto, M. & Umezawa, K., 1994, In : Bioscience, biotechnology, and biochemistry. 58, 9, p. 1549-1552 4 p.

Research output: Contribution to journalArticle

Leukemia L1210
Apoptosis
DNA Fragmentation
Protein-Tyrosine Kinases
Cell death
3 Citations (Scopus)

Inhibition of T Cell Receptor-mediated Signal Transduction by Erbstatin

Imoto, M., Nakamura, T., Tanaka, S. I. & Umezawa, K., 1994, In : Bioscience, biotechnology, and biochemistry. 58, 9, p. 1700-1701 2 p.

Research output: Contribution to journalArticle

Signal transduction
T-Cell Antigen Receptor
Signal Transduction
Interleukin-2
Inositol Phosphates
20 Citations (Scopus)

Involvement of phosphatidylinositol synthesis in the regulation of S phase induction

Imoto, M., Morii, T., Deguchi, A. & Umezawa, K., 1994, In : Experimental Cell Research. 215, 1, p. 228-233 6 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
S Phase
CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase
G1 Phase
Serum
1995
7 Citations (Scopus)

A novel cyclic lipoundecapeptide, pholipeptin, isolated from Pseudomonas sp.

Ui, H., Miyake, T., Iinuma, H., Imoto, M., Hattori, S., Hamada, M., Takeuchi, T., Umezawa, S. & Umezawa, K., 1995 Oct 9, In : Tetrahedron Letters. 36, 41, p. 7479-7480 2 p.

Research output: Contribution to journalArticle

Phosphoinositide Phospholipase C
Trifluoroacetic Acid
Pseudomonas
Nuclear magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
6 Citations (Scopus)

Induction of Erythroid Differentiation in Leukemic K562 Cells by an S-Adenosylhomocysteine Hydrolase Inhibitor, Aristeromycin

Mizutani, Y., Masuoka, S., Imoto, M., Kawada, M. & Umezawa, K., 1995 Feb 6, In : Biochemical and Biophysical Research Communications. 207, 1, p. 69-74 6 p.

Research output: Contribution to journalArticle

Adenosylhomocysteinase
K562 Cells
Methylation
Actinobacteria
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
17 Citations (Scopus)

Inhibition of phosphatidylinositol-specific phospholipase C activity by Fluvirucin B2

Ul, H., Imoto, M. & Umizawa, K., 1995, In : Journal of Antibiotics. 48, 5, p. 387-390 4 p.

Research output: Contribution to journalArticle

Phosphoinositide Phospholipase C
Streptomyces
Phosphatidylinositols
Epidermal Growth Factor
Cytosol
1996
8 Citations (Scopus)

Dendritic Ca2+ response in cereal sensory interneurons of the cricket Gryllus bimaculatus

Ogawa, H., Baba, Y. & Oka, K., 1996 Nov 15, In : Neuroscience Letters. 219, 1, p. 21-24 4 p.

Research output: Contribution to journalArticle

Gryllidae
Interneurons
Neuronal Plasticity
Dendrites
Automatic Data Processing
Fault tolerance
Bandwidth
Recovery
Degradation
Failure analysis
17 Citations (Scopus)

Inhibition of G1 cyclin expression in normal rat kidney cells by inostamycin, a phosphatidylinositol synthesis inhibitor

Deguchi, A., Imoto, M. & Umezawa, K., 1996 Dec, In : Journal of Biochemistry. 120, 6, p. 1118-1122 5 p.

Research output: Contribution to journalArticle

Cyclin G1
Phosphatidylinositols
Rats
Kidney
Cyclin-Dependent Kinase 2
46 Citations (Scopus)

Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells

Simizu, S., Imoto, M., Masuda, N., Takada, M. & Umezawa, K., 1996 Nov 1, In : Cancer Research. 56, 21, p. 4978-4982 5 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Hydrogen Peroxide
Apoptosis
DNA Fragmentation
Hydroxymethylglutaryl-CoA Reductase Inhibitors
3 Citations (Scopus)

Synthesis of ribofuranosyl glycosides of echiguanines A and B, inhibitors of phosphatidylinositol 4-kinase

Sanpei, K., Saito, Y., Imoto, M., Umezawa, K. & Kato, K., 1996 Nov 5, In : Bioorganic and Medicinal Chemistry Letters. 6, 21, p. 2487-2490 4 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Glycosides
Chlorides
echiguanine A
echiguanine B
1997
23 Citations (Scopus)

Enhancement or induction of neurite formation by a protein tyrosine phosphatase inhibitor, 3,4-dephostatin, in growth factor-treated PC12h cells

Fujiwara, S., Watanabe, T., Nagatsu, T., Gohda, J., Imoto, M. & Umezawa, K., 1997 Sep 8, In : Biochemical and Biophysical Research Communications. 238, 1, p. 213-217 5 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Neurites
Intercellular Signaling Peptides and Proteins
Mitogen-Activated Protein Kinases
Phosphorylation

Induction of apoptotic cell death by tyrosine kinase inhibitor

Imoto, M., Simizu, S. & Umezawa, K., 1997, In : Nippon Nogeikagaku Kaishi. 71, 5, p. 523-526 4 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Hydrogen Peroxide
hydrogen peroxide
tyrosine
cell death
24 Citations (Scopus)

Pholipeptin, a novel cyclic lipoundecapeptide from Pseudomonas fluorescens

Ui, H., Miyake, T., Iinuma, H., Imoto, M., Naganawa, H., Hattori, S., Hamada, M., Takeuchi, T., Umezawa, S. & Umezawa, K., 1997, In : Journal of Organic Chemistry. 62, 1, p. 103-108 6 p.

Research output: Contribution to journalArticle

Chirality
Nuclear magnetic resonance
Hydrolysis
Phosphoinositide Phospholipase C
Amino Acids
2 Citations (Scopus)

Preparation and characterization of liposomes containing magnetic particles for magnetic targeting

Tokiwa, Y., Ohta, E., Sato, T., Kasamo, K. & Oka, K., 1997, In : Drug Delivery System. 12, 1, p. 43-48 6 p.

Research output: Contribution to journalArticle

Liposomes
Ferrosoferric Oxide
Magnetic Fields
Drug Delivery Systems
Glass
1 Citation (Scopus)

Screening of phosphatidylinositol turnover inhibitors and regulation of cell cycle progression

Umezawa, K., Deguchi, A. & Imoto, M., 1997, In : Japanese Journal of Cancer and Chemotherapy. 24, 11, p. 1578-1584 7 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase
Cell Cycle
Phosphotransferases
Streptomyces
1998
17 Citations (Scopus)
Vinblastine
Small Cell Lung Carcinoma
Caspase 3
Phosphorylation
Apoptosis
40 Citations (Scopus)
Small Cell Lung Carcinoma
Caspase 3
Protein-Tyrosine Kinases
Hydrogen Peroxide
Peptide Hydrolases
20 Citations (Scopus)

Inhibition of cyclin D1 expression and induction of apoptosis by inostamycin in small cell lung carcinoma cells

Imoto, M., Tanabe, K., Simizu, S., Tashiro, E., Takada, M. & Umezawa, K., 1998 Mar, In : Japanese Journal of Cancer Research. 89, 3, p. 315-322 8 p.

Research output: Contribution to journalArticle

Cyclin D1
Small Cell Lung Carcinoma
Apoptosis
Caspase 3
G1 Phase
10 Citations (Scopus)

Potentiation of paclitaxel cytotoxicity by inostamycin in human small cell lung carcinoma, Ms-1 cells

Simizu, S., Tanabe, K., Tashiro, E., Takada, M., Umezawa, K. & Imoto, M., 1998 Sep, In : Japanese Journal of Cancer Research. 89, 9, p. 970-976 7 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Paclitaxel
Apoptosis
Phosphatidylinositols
inostamycin