Faculty of Pharmacy

Research Output 1975 2020

1975
5 Citations (Scopus)

Incorporation of [2-3h]- and [2-2h3]-acetate by penicillium urticae into griseofulvin and determination of the stereochemistry of isotopes at c-5′

Sato, Y., Machida(Seki), T. & Oda, T., 1975, In : Tetrahedron Letters. 16, 51, p. 4571-4574 4 p.

Research output: Contribution to journalArticle

Griseofulvin
Penicillium
Isotopes
Acetates
1976
32 Citations (Scopus)

A novel biosynthetic study of griseofulvin by 2H nuclear magnetic resonance: Determination of deuterium incorporation from [2-2H3]-acetate by Penicillium urticae

Sato, Y., Oda, T. & Saitô, H., 1976, In : Tetrahedron Letters. 17, 31, p. 2695-2698 4 p.

Research output: Contribution to journalArticle

Griseofulvin
Deuterium
Penicillium
Acetates
Magnetic Resonance Spectroscopy
1 Citation (Scopus)

Environmental behavior on the lens opacification (Japanese)

Iwata, S., Ikemoto, F. & Takehana, M., 1976, In : Journal of Japanese Ophthalmological Society. 80, 9, p. 741-748 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Griseofulvin biosynthesis: New evidence of two acetate-dispositions in the ring a from 13C nuclear magnetic resonance studies

Sato, Y., Oda, T. & Urano, S., 1976, In : Tetrahedron Letters. 17, 44, p. 3971-3974 4 p.

Research output: Contribution to journalArticle

Griseofulvin
Biosynthesis
Acetates
Nuclear magnetic resonance
1977
8 Citations (Scopus)

Kinetics of incorporation of copper(II) into meso-tetraphenylporphine in dimethylformamide. Effect of carboxylate anions

Sugata, S. & Matsushima, Y., 1977, In : Journal of Inorganic and Nuclear Chemistry. 39, 4, p. 729-731 3 p.

Research output: Contribution to journalArticle

Dimethylformamide
carboxylates
Anions
Copper
acetates
29 Citations (Scopus)

Meso tetrapyridylporphins and their metal complexes. Syntheses and physico chemical properties

Sugata, S., Yamanouchi, S. & Matsushima, Y., 1977, In : Chemical and Pharmaceutical Bulletin. 25, 5, p. 884-889 6 p.

Research output: Contribution to journalArticle

Coordination Complexes
Chloroform
Chemical properties
Amides
Acetic Acid
23 Citations (Scopus)
Griseofulvin
Hydroxylation
Stereochemistry
Hydrogenation
Spectrum Analysis
1978
10 Citations (Scopus)
Griseofulvin
Stereochemistry
Deuterium
Penicillium
Biosynthesis
4 Citations (Scopus)

Biochemical studies on human cataract lens. I. Comparison on cation behavior between human and animal in lens opaque development

Iwata, S., Takehana, M. & Nakabayashi, M., 1978, In : Folia Ophthalmologica Japonica. 29, 2, p. 362-368 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Cations involved in cataract formation I. The turbidimetric aspect of lens soluble protein

Iwata, S. & Takehana, M., 1978, In : Folia Ophthalmologica Japonica. 29, 6, p. 855-858 4 p.

Research output: Contribution to journalArticle

Crystallins
Cataract
Cations
3 Citations (Scopus)

Kinetics of incorporation of copper(II) into meso-tetraphenylporphine in dimethylformamide-II. Effects of amines

Sugata, S. & Matsushima, Y., 1978, In : Journal of Inorganic and Nuclear Chemistry. 40, 6, p. 1269-1272 4 p.

Research output: Contribution to journalArticle

Dimethylformamide
Aniline
Amines
Copper
amines
4 Citations (Scopus)

Kinetics of incorporation of zinc(II) into tetraphenylporphine in N,N-dimethylformamide. I. Monohydroxo and acetato complexes

Sugata, S. & Matsushima, Y., 1978, In : Chemical and Pharmaceutical Bulletin. 26, 4, p. 1071-1074 4 p.

Research output: Contribution to journalArticle

Zinc Acetate
Metalloporphyrins
Dimethylformamide
Zinc
Acetates
1979
9 Citations (Scopus)
Magnetic resonance spectroscopy
Deuterium Oxide
Griseofulvin
Sodium Acetate
Starters

Distribution and excretion of N-ethyloxycarbonylaminomethy-L-isoleucine in mice

Fukuma, M., Fujita, H. & Sugimoto, Y., 1979, In : Japanese Journal of Cancer and Chemotherapy. 6, 2, p. 409-417 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
Pyrrolidonecarboxylic Acid
Hepatitis B Surface Antigens
Arginine
Salts
Triclosan
27 Citations (Scopus)

Strain differences in rat liver UDP-glucuronyltransferase activity towards androsterone

Matsui, M., Nagai, F. & Aoyagi, S., 1979, In : Biochemical Journal. 179, 3, p. 483-487 5 p.

Research output: Contribution to journalArticle

Androsterone
Glucuronosyltransferase
Uridine Diphosphate
Liver
Rats
1980
13 Citations (Scopus)

Assay of uridine diphosphate glucuronosyltransferase by high-pressure liquid chromatography

Matsui, M. & Nagai, F., 1980, In : Analytical Biochemistry. 105, 1, p. 141-146 6 p.

Research output: Contribution to journalArticle

High pressure liquid chromatography
Glucuronosyltransferase
Uridine Diphosphate
Glucuronides
Assays
1 Citation (Scopus)
Crystalline Lens
Crystallins
Cataract
Lenses
17 Citations (Scopus)
Yttrium
Negative ions
generators
Anion Exchange Resins
Impurities
Hepatitis B Surface Antigens
Arginine
Amides
Lysine
Esters

pH-dependency in corneal permeability of pilocarpine HCl and evaluation of drug effects

Iwata, S. & Takehana, M., 1980, In : Journal of Pharmacobio-Dynamics. 3, 9

Research output: Contribution to journalArticle

Drug Evaluation
Pilocarpine
Permeability
1981
2 Citations (Scopus)

Mechanism of inactivation of hepatitis B surface antigen by N(α)-cocoyl-L-arginine ethyl ester

Sugimoto, Y. & Toyoshima, S., 1981, In : Antimicrobial Agents and Chemotherapy. 20, 1, p. 120-127 8 p.

Research output: Contribution to journalArticle

Hepatitis B Surface Antigens
Arginine
Lipids
arginine ethyl ester
Antigens
8 Citations (Scopus)

Microbial transformation of (+)- and (-)-dehydrogriseofulvin by Streptomyces species analyzed by 2H nuclear magnetic resonance spectroscopy

Sato, Y., Oda, T. & Saito, H., 1981, In : Chemical and Pharmaceutical Bulletin. 29, 8, p. 2313-2321 9 p.

Research output: Contribution to journalArticle

Optical rotation
Griseofulvin
Enantiomers
Isomerization
Nuclear magnetic resonance spectroscopy
1982

Biochemical characterization of opacification in the crystalline lens

Iwata, S., Kamei, A., Takehana, M., Ikemoto, F., Sano, Y., Horiuchi, M., Yamada, Y., Hikida, M., Kato, M., Sugiura, E., Shimamoto, S., Imayasu, M., Miyauchi, S., Tamai, N., Shirasawa, E., Kimura, S. & Suzuki, K., 1982, In : Journal of Japanese Ophthalmological Society. 86, 11, p. 1919-1943 25 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Biochemical studies on human cataract lens. II. Opacity-related changes of cations, ATP and GSH in various types of human senile cataracts

Iwata, S. & Takehana, M., 1982 Oct, In : Yakugaku Zasshi. 102, 10, p. 940-945 6 p.

Research output: Contribution to journalArticle

Biochemical studies on human cataract lens. III. Relation between opaque situation and adaptation to extraenvironment of lens in vitro

Takehana, M. & Iwata, S., 1982 Oct, In : Yakugaku Zasshi. 102, 10, p. 946-950 5 p.

Research output: Contribution to journalArticle

1983
168 Citations (Scopus)

Activation of 5'-deoxy-5-fluorouridine by thymidine phosphorylase in human tumors

Kono, A., Hara, Y., Sugata, S., Karube, Y., Matsushima, Y. & Ishitsuka, H., 1983, In : Chemical and Pharmaceutical Bulletin. 31, 1, p. 175-178 4 p.

Research output: Contribution to journalArticle

Pentosyltransferases
Uridine Phosphorylase
Floxuridine
Thymidine Phosphorylase
Uridine

Analysis of low molecular weight fractions in human senile cataractous lens

Takehana, M., Takemoto, L. J. & Iwata, S., 1983, In : Japanese Journal of Ophthalmology. 27, 4, p. 585-591 7 p.

Research output: Contribution to journalArticle

Cataract
Lenses
Molecular Weight
High Pressure Liquid Chromatography
Proteins
2 Citations (Scopus)

Appearance of reverse transcriptase activity in human fetal thymus cells stimulated by human b-cell

Ono, A., Saito, H., Tsuchiya, M., Nakamura, T., Higashinakagawa, T., Kondo, S. & Yoshimatsu, H., 1983, In : The Keio journal of medicine. 32, p. 73-80 8 p.

Research output: Contribution to journalArticle

RNA-Directed DNA Polymerase
Human Activities
Thymus Gland
B-Lymphocytes
Mitomycin
3 Citations (Scopus)

Assay for pyrimidine nucleoside phosphorylases in tissue extracts by high-performance liquid chromatography.

Kono, A., Sugata, S., Hara, Y., Tanaka, M., Karube, Y. & Matsushima, Y., 1983 May, In : Chemical and Pharmaceutical Bulletin. 31, 5, p. 1666-1669 4 p.

Research output: Contribution to journalArticle

Pentosyltransferases
Pyrimidine Phosphorylases
Uridine Phosphorylase
High pressure liquid chromatography
Thymidine Phosphorylase
5 Citations (Scopus)

Brain uptake of halogenated products of D-glucal

Homma, Y., Morita-Murase, Y. & Ishii, M., 1983 Sep, In : Journal of Radioanalytical Chemistry. 76, 2, p. 283-288 6 p.

Research output: Contribution to journalArticle

Calcium Gluconate
Glucose
Brain
Halogenation
Halogens

Enzymatic conversion of tegafur to 5-FU in human tumor tissue

Hara, Y., Sugata, S., Kono, A. & Tanaka, M., 1983, In : Japanese Journal of Cancer and Chemotherapy. 10, 6, p. 1511-1517 7 p.

Research output: Contribution to journalArticle

Thymidine Phosphorylase
Tegafur
Liver Neoplasms
Fluorouracil
Stomach Neoplasms
28 Citations (Scopus)

Incorporation of bile acid of low concentration into model and biological membranes studied by H and 31P NMR1

Saitô, H., Sugimoto, Y., Tabeta, R., Suzuki, S., Izumi, G., Kodama, M., Toyoshima, S. & Nagata, C., 1983 Dec, In : Journal of Biochemistry. 94, 6, p. 1877-1887 11 p.

Research output: Contribution to journalArticle

Biological membranes
Biological Models
Lipids
Bile Acids and Salts
Membrane
8 Citations (Scopus)

Microbial transformation of (+)- and (-)-2'-demethoxydehydrogriseofulvin by Streptomyces cinereocrocatus

Oda, T. & Sato, Y., 1983, In : Chemical and Pharmaceutical Bulletin. 31, 3, p. 934-946 13 p.

Research output: Contribution to journalArticle

Optical rotation
Griseofulvin
Enantiomers
Conformations
Substrates
2 Citations (Scopus)

Purification and characterization of calcium ion pump activator in bovine lens

Takehana, M. & Iwata, S., 1983, In : Journal of Japanese Ophthalmological Society. 87, 10, p. 850-854 5 p.

Research output: Contribution to journalArticle

Ion Pumps
Crystallins
Calmodulin
Lenses
Calcium
3 Citations (Scopus)

Rna tumor virus-like particles in thymus cells of patients with myasthenia gravis

Ono, A., Higashinakagawa, T., Kondo, S., Nakamura, T., Saito, H., Suzuki, H., Yoshimatsu, H., Murakami, M. & Tsuchiya, M., 1983, In : The Keio journal of medicine. 32, p. 49-57 9 p.

Research output: Contribution to journalArticle

Myasthenia Gravis
Retroviridae
Virion
Thymus Gland
Thymus Hyperplasia
5 Citations (Scopus)

Stereochemistry of microbial transformation of (+)- and (-)-2'-demethoxydehydrogriseofulvin by Streptomyces cinereocrocatus

Oda, T. & Sato, Y., 1983, In : Chemical and Pharmaceutical Bulletin. 31, 10, p. 3446-3453 8 p.

Research output: Contribution to journalArticle

Hydrogenation
Streptomyces
Magnetic Resonance Spectroscopy
Pharmaceutical Societies
Griseofulvin
1984
16 Citations (Scopus)

Activator of ca2 + -transport in the Lens

Iwata, S., Shirasawa, E. & Takehana, M., 1984, In : Current Eye Research. 3, 5, p. 717-722 6 p.

Research output: Contribution to journalArticle

Lenses
Adenosine Triphosphatases
Calmodulin
Enzyme Activators
Chlorpromazine
8 Citations (Scopus)
Bile Acids and Salts
Colon
Deoxycholic Acid
Magnetic Resonance Spectroscopy
Lithocholic Acid
10 Citations (Scopus)

Biochemical studies on the use of sodium hyaluronate in the anterior Eye segment. I. Variation of protein and ascorbic acid concentration in rabbit aqueous humor

Iwata, S., Miyauchi, S. & Takehana, M., 1984, In : Current Eye Research. 3, 4, p. 605-610 6 p.

Research output: Contribution to journalArticle

Anterior Eye Segment
Aqueous Humor
Hyaluronic Acid
Ascorbic Acid
Rabbits
106 Citations (Scopus)
Ornithine Decarboxylase
Lipoxygenase
Tetradecanoylphorbol Acetate
Catechin
Flavonoids
8 Citations (Scopus)

Structure-activity relationships of nitrosamines and nitramines which stimulate UDP-glucuronosyltransferase activities in vitro

Matsui, M., Nagai, F., Suzuki, E. & Okada, M., 1984 Aug 15, In : Biochemical Pharmacology. 33, 16, p. 2647-2651 5 p.

Research output: Contribution to journalArticle

Nitrosamines
Glucuronosyltransferase
Structure-Activity Relationship
Transferases
Phenolphthalein
27 Citations (Scopus)

Substrate specificity of a thymidine phosphorylase in human liver tumor.

Kono, A., Hara, Y., Sugata, S., Matsushima, Y. & Ueda, T., 1984 May, In : Chemical and Pharmaceutical Bulletin. 32, 5, p. 1919-1921 3 p.

Research output: Contribution to journalArticle

Pentosyltransferases
Uridine Phosphorylase
Thymidine Phosphorylase
Uridine
Liver
3 Citations (Scopus)
Nerve Tissue Proteins
Microtubule Proteins
Griseofulvin
Stereoisomerism
Microtubule-Associated Proteins
1985
6 Citations (Scopus)

Analysis of antipyretics by semimicro liquid chromatography

Matsushima, Y., Itoh, Y., Niyomura, M., Takakusagi, K. & Takai, N., 1985 Sep 20, In : Journal of Chromatography A. 332, C, p. 269-273 5 p.

Research output: Contribution to journalArticle

Antipyretics
divinyl benzene
Liquid chromatography
Liquid Chromatography
Glyceryl Ethers
1 Citation (Scopus)

Band Sharpening by Acid in Polyacrylamide Gel Electrophoresis

Nishizawa, H., Iida, M. & Abe, Y., 1985, In : Analytical Sciences. 1, 5, p. 451-454 4 p.

Research output: Contribution to journalArticle

Electrophoresis
Acids
Acetic Acid
Coloring Agents
Gels
6 Citations (Scopus)

Biosynthesis of proteoglycans by lens epithelial cells of cataractous mouse (Nakano strain)

Nakazawa, K., Takehana, M. & Iwata, S., 1985, In : Experimental Eye Research. 40, 4, p. 609-618 10 p.

Research output: Contribution to journalArticle

Proteoglycans
Cataract
Lenses
Capsules
Epithelial Cells
2 Citations (Scopus)

Correlation between enhancement of natural killer (NK) activity by an immunopotentiator (OK-432) and resistance to human hepatoma cell implantation in nude mice

Saito, H., Morizane, T., Kumagai, N., Inagaki, Y., Nakamura, T., Satoh, I., Iino, A., Matsumura, S., Kawamura, N. & Tsuchiya, M., 1985, In : Japanese Journal of Gastroenterology. 82, 12, p. 2923-2929 7 p.

Research output: Contribution to journalArticle

Neoplasm Transplantation
Inbred BALB C Mouse
Experimental Liver Neoplasms
Picibanil
Immunologic Adjuvants
37 Citations (Scopus)

Effects of chalcone derivatives on lipoxygenase and cyclooxygenase activities of mouse epidermis

Nakadate, T., Yokota, E., Yamamoto, S. & Kato, R., 1985, In : Prostaglandins. 30, 3, p. 357-368 12 p.

Research output: Contribution to journalArticle

Chalcone
Arachidonate 12-Lipoxygenase
Lipoxygenase
Prostaglandin-Endoperoxide Synthases
Epidermis
15 Citations (Scopus)

Fabric reinforced polyacrylamide gels for electroblotting

Nishizawa, H., Murakami, A., Hayashi, N., Iida, M. & Abe, Y., 1985, In : Electrophoresis. 6, 7, p. 349-350 2 p.

Research output: Contribution to journalArticle

Egg White
Collodion
Isoelectric Point
Isoelectric Focusing
Electric currents