Faculty of Pharmacy

Research Output 1975 2020

2019
1 Citation (Scopus)

Further Evidence Regarding the Important Role of Chlorine Atoms of Aripiprazole on Binding to the Site II Area of Human Albumin

Sakurama, K., Nishi, K., Imoto, S., Hashimoto, M., Komatsu, T., Morita, Y., Taguchi, K., Otagiri, M. & Yamasaki, K., 2019 Jan 1, (Accepted/In press) In : Journal of Pharmaceutical Sciences.

Research output: Contribution to journalArticle

Chlorine
Albumins
Binding Sites
Circular Dichroism
Aripiprazole
1 Citation (Scopus)

Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

Katsuda, T., Matsuzaki, J., Yamaguchi, T., Yamada, Y., Prieto-Vila, M., Hosaka, K., Takeuchi, A., Saito, Y. & Ochiya, T., 2019 Aug 8, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Hepatocytes
Stem Cells
Liver
Cell Transplantation
Liver Transplantation

Glucose depletion enhances the stem cell phenotype and gemcitabine resistance of cholangiocarcinoma organoids through AKT phosphorylation and reactive oxygen species

Yoshikawa, N., Saito, Y., Manabe, H., Nakaoka, T., Uchida, R., Furukawa, R., Muramatsu, T., Sugiyama, Y., Kimura, M. & Saito, H., 2019 Dec, In : Cancers. 11, 12, 1993.

Research output: Contribution to journalArticle

Open Access
gemcitabine
Organoids
Cholangiocarcinoma
Reactive Oxygen Species
Stem Cells

Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids

Miyamoto, J., Igarashi, M., Watanabe, K., Karaki, S. I., Mukouyama, H., Kishino, S., Li, X., Ichimura, A., Irie, J., Sugimoto, Y., Mizutani, T., Sugawara, T., Miki, T., Ogawa, J., Drucker, D. J., Arita, M., Itoh, H. & Kimura, I., 2019 Dec 1, In : Nature communications. 10, 1, 4007.

Research output: Contribution to journalArticle

Open Access
obesity
diets
fatty acids
Nutrition
Unsaturated Fatty Acids

Identification of glycyrrhizin metabolites in humans and of a potential biomarker of liquorice-induced pseudoaldosteronism: a multi-centre cross-sectional study

Takahashi, K., Yoshino, T., Maki, Y., Ishiuchi, K., Namiki, T., Ogawa-Ochiai, K., Minamizawa, K., Makino, T., Nakamura, T., Mimura, M. & Watanabe, K., 2019 Nov 1, In : Archives of Toxicology. 93, 11, p. 3111-3119 9 p.

Research output: Contribution to journalArticle

Liddle Syndrome
Glycyrrhizic Acid
Glycyrrhiza
Biomarkers
Metabolites

IFPA meeting 2018 workshop report II: Abnormally invasive placenta; inflammation and infection; preeclampsia; gestational trophoblastic disease and drug delivery

Albrecht, C., Chamley, L., Charnock-Jones, D. S., Collins, S., Fujiwara, H., Golos, T., Grayo, S., Hannan, N., Harris, L., Ichizuka, K., Illsley, N. P., Iwashita, M., Kallol, S., Al-Khan, A., Lash, G., Nagamatsu, T., Nakashima, A., Niimi, K., Nomoto, M., Redman, C. & 8 others, Saito, S., Tanimura, K., Tomi, M., Usui, H., Vatish, M., Wolfe, B., Yamamoto, E. & O'Tierney-Ginn, P., 2019 Jan 1, In : Placenta.

Research output: Contribution to journalArticle

Gestational Trophoblastic Disease
Pre-Eclampsia
Placenta
Inflammation
Education
Open Access
Human Influenza
Japan
Vaccination
Datasets
Occupational Health

Inhibitory kinetics of fruit components on CYP2C19 activity

Seki, H., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2019 Jan 1, In : Drug Metabolism And Pharmacokinetics.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Fruit
Citrus paradisi
Food-Drug Interactions
Omeprazole
3 Citations (Scopus)

Investigation of anti-tumor effect of doxorubicin-loaded human serum albumin nanoparticles prepared by a desolvation technique

Kimura, K., Yamasaki, K., Nishi, K., Taguchi, K. & Otagiri, M., 2019 Jun 1, In : Cancer Chemotherapy and Pharmacology. 83, 6, p. 1113-1120 8 p.

Research output: Contribution to journalArticle

Serum Albumin
Nanoparticles
Doxorubicin
Tumors
Neoplasms

Irinotecan-induced gastrointestinal damage impairs the absorption of dabigatran etexilate

Hattori, T., Imaoka, A., Akiyoshi, T. & Ohtani, H., 2019 Nov 1, In : Biopharmaceutics and Drug Disposition. 40, 9, p. 315-324 10 p.

Research output: Contribution to journalArticle

irinotecan
P-Glycoprotein
Biological Availability
Partial Thromboplastin Time
Dabigatran

LAT1-Targeting Thermoresponsive Liposomes for Effective Cellular Uptake by Cancer Cells

Maekawa-Matsuura, M., Fujieda, K., Maekawa, Y., Nishimura, T., Nagase, K. & Kanazawa, H., 2019 Apr 8, In : ACS Omega. 4, 4, p. 6443-6451 9 p.

Research output: Contribution to journalArticle

Open Access
Amino Acid Transport Systems
Liposomes
Amino acids
Cells
Tyrosine

LC–MS analysis of saponins of Achyranthes root in the Japanese market

Kuwada, K., Kawase, S., Nakata, K., Shinya, N., Narukawa, Y., Fuchino, H., Kawahara, N. & Kiuchi, F., 2019 Jan 1, (Accepted/In press) In : Journal of Natural Medicines.

Research output: Contribution to journalArticle

Achyranthes
Saponins
1-Butanol
Water
Peroxides
Biological Products
Lipase
Hydrolysis
Esters
Candida antarctica lipase B
2 Citations (Scopus)

Lipidomics needs more standardization

Lipidomics Standards Initiative Consortium, 2019 Aug 1, In : Nature Metabolism. 1, 8, p. 745-747 3 p.

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Liposomes with temperature-responsive reversible surface properties

Nemoto, R., Fujieda, K., Hiruta, Y., Hishida, M., Ayano, E., Maitani, Y., Nagase, K. & Kanazawa, H., 2019 Apr 1, In : Colloids and Surfaces B: Biointerfaces. 176, p. 309-316 8 p.

Research output: Contribution to journalArticle

Surface Properties
Liposomes
surface properties
Surface properties
Polymers
2 Citations (Scopus)

Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine

Akiyama, S., Matsuoka, K., Fukuda, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Motobayashi, M., Suzuki, K., Takenaka, K., Fujii, T., Saito, E., Nagahori, M. & 5 others, Ohtsuka, K., Mochizuki, M., Watanabe, M., Hashiguchi, M. & Kanai, T., 2019 Jan 1, In : Journal of Gastroenterology and Hepatology (Australia).

Research output: Contribution to journalReview article

Inflammatory Bowel Diseases
Erythrocyte Indices
Leukopenia
Leukocyte Count
Genotype
1 Citation (Scopus)

Maintenance of Intestinal Epithelial Homeostasis by Zinc Transporters

Ohashi, W., Hara, T., Takagishi, T., Hase, K. & Fukada, T., 2019 Jan 1, In : Digestive Diseases and Sciences.

Research output: Contribution to journalReview article

Zinc
Homeostasis
Maintenance
Gastrointestinal Diseases
Micronutrients
1 Citation (Scopus)

Mass spectrometry data repository enhances novel metabolite discoveries with advances in computational metabolomics

Tsugawa, H., Satoh, A., Uchino, H., Cajka, T., Arita, M. & Arita, M., 2019 Jan 1, In : Metabolites. 9, 6, 119.

Research output: Contribution to journalArticle

Open Access
Metabolomics
Metabolites
Mass spectrometry
Mass Spectrometry
Haptophyta

Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis

Nishida, K., Hasegawa, A., Yamasaki, S., Uchida, R., Ohashi, W., Kurashima, Y., Kunisawa, J., Kimura, S., Iwanaga, T., Watarai, H., Hase, K., Ogura, H., Nakayama, M., Kashiwakura, J. I., Okayama, Y., Kubo, M., Ohara, O., Kiyono, H., Koseki, H., Murakami, M. & 1 others, Hirano, T., 2019 Dec 1, In : Scientific reports. 9, 1, 10842.

Research output: Contribution to journalArticle

Open Access
Mast Cells
Wound Healing
Zinc
Interleukin-6
Skin

Medications and fall risk: a case–control study in nursing home residents in Japan

Park, H., Satoh, H., Miki, A., Maki, H., Asai, K., Shiraishi, A., Urushihara, H. & Sawada, Y., 2019 Jan 1, In : Aging Clinical and Experimental Research.

Research output: Contribution to journalArticle

Nursing Homes
Japan
Accidental Falls
Facility Regulation and Control
Memantine

Methotrexate significantly induces apoptosis by inhibiting STAT3 activation in NPM-ALK-positive ALCL cells

Uchihara, Y., Komori, R., Tago, K., Tamura, H. & Funakoshi-Tago, M., 2019 Dec, In : Biochemical Pharmacology. 170, 113666.

Research output: Contribution to journalArticle

Transcription Factor 3
Anaplastic Large-Cell Lymphoma
STAT3 Transcription Factor
Methotrexate
Transducers

Mixed polymer brush as a functional ligand of silica beads for temperature-modulated hydrophobic and electrostatic interactions

Nagase, K., Kitazawa, S., Yamada, S., Akimoto, A. M. & Kanazawa, H., 2019 Jan 1, (Accepted/In press) In : Analytica Chimica Acta.

Research output: Contribution to journalArticle

Brushes
Coulomb interactions
Static Electricity
Hydrophobic and Hydrophilic Interactions
Silicon Dioxide
1 Citation (Scopus)

Mucin O-glycans facilitate symbiosynthesis to maintain gut immune homeostasis

Yamada, T., Hino, S., Iijima, H., Genda, T., Aoki, R., Nagata, R., Han, K. H., Hirota, M., Kinashi, Y., Oguchi, H., Suda, W., Furusawa, Y., Fujimura, Y., Kunisawa, J., Hattori, M., Fukushima, M., Morita, T. & Hase, K., 2019 Jan 1, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Open Access
Butyrates
Mucins
Polysaccharides
Homeostasis
Ulcerative Colitis

MULTIOMICS ANALYSIS OF HUMAN EOSINOPHILS REVEALED MOLECULAR MECHANISM OF EOSINOPHILIC RHINOSINUSITIS AND SEVERE ASTHMA

Miyata, J., Kawashima, Y., Ohara, O., Betsuyaku, T., Fukunaga, K. & Arita, M., 2019 Jan 1, In : Arerugi = [Allergy]. 68, 2, p. 86-91 6 p.

Research output: Contribution to journalArticle

Eosinophils
Asthma
3 Citations (Scopus)

MZB1 promotes the secretion of J-chain–containing dimeric IgA and is critical for the suppression of gut inflammation

Xiong, E., Li, Y., Min, Q., Cui, C., Liu, J., Hong, R., Lai, N., Wang, Y., Sun, J., Matsumoto, R., Takahashi, D., Hase, K., Shinkura, R., Tsubata, T. & Wang, J. Y., 2019 Jan 1, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13480-13489 10 p.

Research output: Contribution to journalArticle

Immunoglobulin A
Inflammation
Colitis
Mucosal Immunity
Molecular Chaperones

N-Acetyl cysteine prevents activities of STAT3 inhibitors, Stattic and BP-1-102 independently of its antioxidant properties

Uchihara, Y., Ohe, T., Mashino, T., Kidokoro, T., Tago, K., Tamura, H. & Funakoshi-Tago, M., 2019 Dec, In : Pharmacological Reports. 71, 6, p. 1067-1078 12 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Cysteine
Antioxidants
Apoptosis
Reactive Oxygen Species

Nanodiscs for Structural Biology in a Membranous Environment

Yokogawa, M., Fukuda, M. & Osawa, M., 2019 Jan 1, In : Chemical & pharmaceutical bulletin. 67, 4, p. 321-326 6 p.

Research output: Contribution to journalArticle

Open Access
Membrane Proteins
Lipid bilayers
Lipid Bilayers
Micelles
Detergents

Novel pharmacological effects of poly (ADP-ribose) polymerase inhibitor rucaparib on the lactate dehydrogenase pathway

Nonomiya, Y., Noguchi, K., Katayama, K. & Sugimoto, Y., 2019 Mar 19, In : Biochemical and Biophysical Research Communications. 510, 4, p. 501-507 7 p.

Research output: Contribution to journalArticle

L-Lactate Dehydrogenase
Pharmacology
Ovarian Neoplasms
Repair
DNA Repair-Deficiency Disorders
4 Citations (Scopus)

Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis

Ishihara, T., Yoshida, M. & Arita, M., 2019 Aug 23, In : International immunology. 31, 9, p. 559-567 9 p.

Research output: Contribution to journalArticle

Open Access
Inflammation Mediators
Omega-3 Fatty Acids
Unsaturated Fatty Acids
Homeostasis
Lipoxygenases

Oncogenic Ras mutant causes the hyperactivation of NF-κB via acceleration of its transcriptional activation

Tago, K., Funakoshi-Tago, M., Ohta, S., Kawata, H., Saitoh, H., Horie, H., Aoki-Ohmura, C., Yamauchi, J., Tanaka, A., Matsugi, J. & Yanagisawa, K., 2019 Nov 1, In : Molecular Oncology. 13, 11, p. 2493-2510 18 p.

Research output: Contribution to journalArticle

Open Access
Transcriptional Activation
p38 Mitogen-Activated Protein Kinases
Neoplasms
Cell Cycle
Phosphorylation

Pharmaceutical Strategy to Protect Skin Barrier Function

Ooi, K. & Yamaura, K., 2019 Jan 1, In : Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 139, 12, 1 p.

Research output: Contribution to journalArticle

Open Access

Phenotypic traits of mesenchymal stem cell sheets fabricated by temperature-responsive cell culture plate: Structural characteristics of MSC sheets

Nakao, M., Kim, K., Nagase, K., Grainger, D. W., Kanazawa, H. & Okano, T., 2019 Nov 28, In : Stem Cell Research and Therapy. 10, 1, 353.

Research output: Contribution to journalArticle

Open Access
Stem cells
Mesenchymal Stromal Cells
Cell culture
Stem Cells
Cell Culture Techniques

Prediction of deficiency-excess pattern in Japanese Kampo medicine: Multi-centre data collection

Maeda-Minami, A., Yoshino, T., Katayama, K., Horiba, Y., Hikiami, H., Shimada, Y., Namiki, T., Tahara, E., Minamizawa, K., Muramatsu, S., Yamaguchi, R., Imoto, S., Miyano, S., Mima, H., Mimura, M., Nakamura, T. & Watanabe, K., 2019 Aug 1, In : Complementary Therapies in Medicine. 45, p. 228-233 6 p.

Research output: Contribution to journalArticle

Kampo Medicine
Blood Pressure
Observational Studies
Japan
Body Mass Index
2 Citations (Scopus)

Preparation, Characterization, and in Vitro/in Vivo Evaluation of Paclitaxel-Bound Albumin-Encapsulated Liposomes for the Treatment of Pancreatic Cancer

Okamoto, Y., Taguchi, K., Sakuragi, M., Imoto, S., Yamasaki, K. & Otagiri, M., 2019 May 17, In : ACS Omega. 4, 5, p. 8693-8700 8 p.

Research output: Contribution to journalArticle

Open Access
Liposomes
Paclitaxel
Bovine Serum Albumin
Membrane Lipids
Albumin-Bound Paclitaxel

Processing grapefruit juice with γ-cyclodextrin attenuates its inhibitory effect on cytochrome P450 3A activity

Yamasaki, K., Iohara, D., Oyama, Y., Nishizaki, N., Kawazu, S., Nishi, K., Kadowaki, D., Taguchi, K., Otagiri, M. & Seo, H., 2019 Jan 1, (Accepted/In press) In : Journal of Pharmacy and Pharmacology.

Research output: Contribution to journalArticle

Citrus paradisi
Cytochrome P-450 CYP3A
Cyclodextrins
bergamottin
Pharmaceutical Preparations
Drug Discovery
Communicable Diseases
Research
Pharmaceutical Preparations
Neoplasms
Open Access
Organoids
Epigenomics
Publications

Quantification of ENT1 and ENT2 Proteins at the Placental Barrier and Contribution of These Transporters to Ribavirin Uptake

Nishimura, T., Sano, Y., Takahashi, Y., Noguchi, S., Uchida, Y., Takagi, A., Tanaka, T., Katakura, S., Nakashima, E., Tachikawa, M., Maruyama, T., Terasaki, T. & Tomi, M., 2019 Jan 1, (Accepted/In press) In : Journal of Pharmaceutical Sciences.

Research output: Contribution to journalArticle

Open Access
Pregnancy Proteins
Ribavirin
Oocytes
Complementary RNA
Dipyridamole

Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function

Imanishi, T., Unno, M., Kobayashi, W., Yoneda, N., Matsuda, S., Ikeda, K., Hoshii, T., Hirao, A., Miyake, K., Barber, G. N., Arita, M., Ishii, K. J., Akira, S. & Saito, T., 2019 Jan 1, In : Life Science Alliance. 2, 1, e201800282.

Research output: Contribution to journalArticle

Open Access
T-cells
interferons
Interferons
T-lymphocytes
Genes
2 Citations (Scopus)

Regorafenib-Induced Hand-Foot Skin Reaction Is More Severe on the Feet Than on the Hands

Nonomiya, Y., Yokokawa, T., Kawakami, K., Kobayashi, K., Aoyama, T., Takiguchi, T., Sugisaki, T., Suzuki, K., Suenaga, M., Wakatsuki, T., Yamaguchi, K., Sugimoto, Y. & Hama, T., 2019 May 7, In : Oncology research. 27, 5, p. 551-556 6 p.

Research output: Contribution to journalArticle

Foot
Hand
Skin
regorafenib
Colorectal Neoplasms

Regulation of inflammatory response of macrophages and induction of regulatory T cells by using retinoic acid-loaded nanostructured lipid carrier

Zai, K., Ishihara, N., Oguchi, H., Hirota, M., Kishimura, A., Mori, T., Hase, K. & Katayama, Y., 2019 Jan 1, (Accepted/In press) In : Journal of Biomaterials Science, Polymer Edition.

Research output: Contribution to journalArticle

T-cells
Macrophages
Regulatory T-Lymphocytes
Tretinoin
Lipids

Renal dysfunction and anemia associated with long-term imatinib treatment in patients with chronic myelogenous leukemia

Sakurai, M., Kikuchi, T., Karigane, D., Kasahara, H., Matsuki, E., Hashida, R., Yamane, Y., Abe, R., Koda, Y., Toyama, T., Kato, J., Shimizu, T., Yokoyama, Y., Suzuki, S., Nakamura, T., Okamoto, S. & Mori, T., 2019 Mar 20, In : International journal of hematology. 109, 3, p. 292-298 7 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Anemia
Hemoglobins
Glomerular Filtration Rate
Kidney

Sarcopenia in chronic kidney disease: Factors, mechanisms, and therapeutic interventions

Watanabe, H., Enoki, Y. & Maruyama, T., 2019 Jan 1, In : Biological and Pharmaceutical Bulletin. 42, 9, p. 1437-1445 9 p.

Research output: Contribution to journalArticle

Open Access
Sarcopenia
Chronic Renal Insufficiency
Muscles
Myostatin
Therapeutics

Significance of peripheral mononuclear cells producing interferon-γ in response to insulin B:9–23-related peptides in subtypes of type 1 diabetes

Oikawa, Y., Sakamoto, K., Satomura, A., Haisa, A., Katsuki, T., Hattori, Y., Inoue, I., Noda, M. & Shimada, A., 2019 Nov, In : Clinical Immunology. 208, 108260.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Interferons
Peptides
Blood Cells
Amino Acids

Site-selective synthesis of acacetin and genkwanin through lipase-catalyzed deacetylation of apigenin 5,7-diacetate and subsequent methylation

Fujita, R., Mandal, S., Hanaya, K., Shoji, M., Higashibayashi, S. & Sugai, T., 2019 Jan 1, In : Heterocycles. 99, 1, p. 638-648 11 p.

Research output: Contribution to journalArticle

Apigenin
Methylation
Lipase
Ions
Porifera

SNAIL- and SLUG-induced side population phenotype of HCT116 human colorectal cancer cells and its regulation by BET inhibitors

Kato, Y., Kondo, S., Itakura, T., Tokunaga, M., Hatayama, S., Katayama, K. & Sugimoto, Y., 2019 Jan 1, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

irinotecan
Side-Population Cells
Epithelial-Mesenchymal Transition
Colorectal Neoplasms
Cells
5 Citations (Scopus)

Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice

Kimura, S., Kobayashi, N., Nakamura, Y., Kanaya, T., Takahashi, D., Fujiki, R., Mutoh, M., Obata, Y., Iwanaga, T., Nakagawa, T., Kato, N., Sato, S., Kaisho, T., Ohno, H. & Hase, K., 2019 Apr 1, In : The Journal of experimental medicine. 216, 4, p. 831-846 16 p.

Research output: Contribution to journalArticle

Open Access
Weaning
Immunoglobulin A
Mucosal Immunity
Antigens
Peyer's Patches

Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel

Kano, H., Toyama, Y., Imai, S., Iwahashi, Y., Mase, Y., Yokogawa, M., Osawa, M. & Shimada, I., 2019 Dec 1, In : Nature communications. 10, 1, 2008.

Research output: Contribution to journalArticle

Open Access
Inwardly Rectifying Potassium Channel
G-Protein-Coupled Receptors
GTP-Binding Proteins
Chemical activation
proteins

Support for fungal infection treatment mediated by pharmacist-led antifungal stewardship activities

Samura, M., Hirose, N., Kurata, T., Ishii, J., Nagumo, F., Takada, K., Koshioka, S., Uchida, M., Yamamoto, S., Inoue, J., Enoki, Y., Taguchi, K., Ishida, A., Sekine, H., Kunika, N., Kunishima, H. & Matsumoto, K., 2019 Jan 1, (Accepted/In press) In : Journal of Infection and Chemotherapy.

Research output: Contribution to journalArticle

Mycoses
Pharmacists
Candidemia
Health Expenditures
General Hospitals

Synthesis and antitumor activity of novel pyridinium fullerene derivatives

Yasuno, T., Ohe, T., Ikeda, H., Takahashi, K., Nakamura, S. & Mashino, T., 2019 Jan 1, In : International journal of nanomedicine. 14, p. 6325-6337 13 p.

Research output: Contribution to journalArticle

Open Access
Fullerenes
Derivatives
Heterografts
Cell Line
Lead compounds