Faculty of Pharmacy

Research Output 1975 2020

2018
1 Citation (Scopus)

Factors predicting the therapeutic response to methotrexate in Japanese patients with rheumatoid arthritis: A hospital-based cohort study

Hakamata, J., Kaneko, Y., Shimizu, M., Yamaoka, K., Maruyama, J., Takeuchi, T., Mochizuki, M. & Hashiguchi, M., 2018 Jan 1, In : Biological and Pharmaceutical Bulletin. 41, 9, p. 1414-1422 9 p.

Research output: Contribution to journalArticle

Methotrexate
Rheumatoid Arthritis
Cohort Studies
Therapeutics
Genotype
4 Citations (Scopus)

Formal synthesis of englerin A utilizing regio- and diastereoselective [4+3] cycloaddition

Hagihara, S., Hanaya, K., Sugai, T. & Shoji, M., 2018 Feb 1, In : Journal of Antibiotics. 71, 2, p. 257-262 6 p.

Research output: Contribution to journalArticle

Guaiane Sesquiterpenes
Phyllanthus
Kidney Neoplasms
Cycloaddition Reaction
Ether
2 Citations (Scopus)

Formal total synthesis of (-)-hamigeran B from a chemo-enzymatically prepared building block with quaternary chiral center

Kuwata, K., Fujita, R., Hanaya, K., Higashibayashi, S. & Sugai, T., 2018 Jan 1, (Accepted/In press) In : Tetrahedron.

Research output: Contribution to journalArticle

Hydrogenation
Alcohol Oxidoreductases
Stereochemistry
Cyclization
Catalysis
2 Citations (Scopus)

Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR

Maruyama, T., Imai, S., Kusakizako, T., Hattori, M., Ishitani, R., Nureki, O., Ito, K., Maturana, A. D., Shimada, I. & Osawa, M., 2018 Apr 3, In : eLife. 7, e31596.

Research output: Contribution to journalArticle

Binding Sites
Nuclear magnetic resonance
Ions
Homeostasis
Divalent Cations
1 Citation (Scopus)

Gene expression of A6-like subgroup of ATP-binding cassette transporters in mouse brain parenchyma and microvessels

Tachikawa, M., Toki, H., Watanabe, M., Tomi, M., Hosoya, K. I. & Terasaki, T., 2018 Mar 8, (Accepted/In press) In : Anatomical Science International. p. 1-8 8 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Microvessels
Gene Expression
Brain
Endothelial Cells
2 Citations (Scopus)

Heat shock protein 90 inhibitors overcome the resistance to Fms-like tyrosine kinase 3 inhibitors in acute myeloid leukemia

Katayama, K., Noguchi, K. & Sugimoto, Y., 2018 Sep 1, In : Oncotarget. 9, 76, p. 34240-34258 19 p.

Research output: Contribution to journalArticle

fms-Like Tyrosine Kinase 3
HSP90 Heat-Shock Proteins
Acute Myeloid Leukemia
4'-N-benzoylstaurosporine
Protein-Tyrosine Kinases

Hit-to-Lead in Academia: Discovery of a Protein-Protein Interaction Inhibitor of Keap1-Nrf2

Yasuda, D., Obata, R., Takahashi, K., Ohe, T. & Mashino, T., 2018 Jan 1, In : Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 138, 8, p. 1059-1065 7 p.

Research output: Contribution to journalReview article

Proteins
Drug Discovery
Kelch-Like ECH-Associated Protein 1
Lead
Protein Stability
11 Citations (Scopus)

Hydroxytyrosol butyrate inhibits 6-OHDA-induced apoptosis through activation of the Nrf2/HO-1 axis in SH-SY5Y cells

Tago, M., Sakata, T., Fujiwara, S., Sakakura, A., Sugai, T., Tago, K. & Tamura, H., 2018 Sep 5, In : European Journal of Pharmacology. 834, p. 246-256 11 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Heme Oxygenase-1
Butyrates
Oxidopamine
Apoptosis
1 Citation (Scopus)

Hypotaurine is a substrate of GABA transporter family members GAT2/Slc6a13 and TAUT/Slc6a6

Nishimura, T., Higuchi, K., Yoshida, Y., Sugita-Fujisawa, Y., Kojima, K., Sugimoto, M., Santo, M., Tomi, M. & Nakashima, E., 2018 Jan 1, In : Biological and Pharmaceutical Bulletin. 41, 10, p. 1523-1529 7 p.

Research output: Contribution to journalArticle

Acids
Cysteamine
Taurine
Oxidative Stress
hypotaurine
1 Citation (Scopus)

Identification of mesothelioma-specific sialylated epitope recognized with monoclonal antibody SKM9-2 in a mucin-like membrane protein HEG1

Matsuura, R., Kaji, H., Tomioka, A., Sato, T., Narimatsu, H., Moriwaki, Y., Misawa, H., Imai, K. & Tsuji, S., 2018 Dec 1, In : Scientific Reports. 8, 1, 14251.

Research output: Contribution to journalArticle

Mesothelioma
Mucins
Epitopes
Membrane Proteins
Monoclonal Antibodies
5 Citations (Scopus)

Identification of Protein Targets of 12/15-Lipoxygenase-Derived Lipid Electrophiles in Mouse Peritoneal Macrophages Using Omega-Alkynyl Fatty Acid

Isobe, Y., Kawashima, Y., Ishihara, T., Watanabe, K., Ohara, O. & Arita, M., 2018 Apr 20, In : ACS Chemical Biology. 13, 4, p. 887-893 7 p.

Research output: Contribution to journalArticle

Macrophages
Peritoneal Macrophages
Fatty Acids
Lipids
Proteins
1 Citation (Scopus)

IL-10 promoter transactivation by the viral K-RTA protein involves the host-cell transcription factors, specificity proteins 1 and 3

Miyazawa, M., Noguchi, K., Kujirai, M., Katayama, K., Yamagoe, S. & Sugimoto, Y., 2018 Jan 12, In : Journal of Biological Chemistry. 293, 2, p. 662-676 15 p.

Research output: Contribution to journalArticle

Sp3 Transcription Factor
Sp1 Transcription Factor
Human Herpesvirus 8
Transcription
Interleukin-10
2 Citations (Scopus)

Immunomodulatory Effects of Drugs for Effective Cancer Immunotherapy

Matsushita, M. & Kawaguchi, M., 2018 Jan 1, In : Journal of Oncology. 2018, 8653489.

Research output: Contribution to journalReview article

Immunotherapy
Pharmaceutical Preparations
Neoplasms
Immunity
Hydroxymethylglutaryl-CoA Reductase Inhibitors
9 Citations (Scopus)

Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system

Saito, Y., Nakaoka, T., Muramatsu, T., Ojima, H., Sukeda, A., Sugiyama, Y., Uchida, R., Furukawa, R., Kitahara, A., Sato, T., Kanai, Y. & Saito, H., 2018 Dec 1, In : Scientific Reports. 8, 1, 2821.

Research output: Contribution to journalArticle

Organoids
Cholangiocarcinoma
Hepatocytes
Intrahepatic Bile Ducts
Cytochrome P-450 CYP3A
7 Citations (Scopus)

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes

Komine, O., Yamashita, H., Fujimori-Tonou, N., Koike, M., Jin, S., Moriwaki, Y., Endo, F., Watanabe, S., Uematsu, S., Akira, S., Uchiyama, Y., Takahashi, R., Misawa, H. & Yamanaka, K., 2018 Mar 22, (Accepted/In press) In : Cell Death and Differentiation. p. 1-17 17 p.

Research output: Contribution to journalArticle

Deficiency Diseases
Amyotrophic Lateral Sclerosis
Astrocytes
Disease Progression
Myeloid Differentiation Factor 88
4 Citations (Scopus)

Intestinal epithelial cell-specific deletion of α-mannosidase II ameliorates experimental colitis

Suzuki, K., Yamada, T., Yamazaki, K., Hirota, M., Ishihara, N., Sakamoto, M., Takahashi, D., Iijima, H. & Hase, K., 2018 Jan 1, In : Cell Structure and Function. 43, 1, p. 25-39 15 p.

Research output: Contribution to journalArticle

Colitis
Inflammatory Bowel Diseases
Epithelial Cells
Glycosylation
Chemokines
4 Citations (Scopus)

In vivo drug delivery efficiency of albumin-encapsulated liposomes as hydrophobic drug carriers

Okamoto, Y., Taguchi, K., Sakuragi, M., Imoto, S., Yamasaki, K. & Otagiri, M., 2018 Oct 1, In : Journal of Drug Delivery Science and Technology. 47, p. 62-66 5 p.

Research output: Contribution to journalArticle

Drug Carriers
Liposomes
Albumins
Tacrolimus
Pharmaceutical Preparations
5 Citations (Scopus)

Involvement of endocytosis in the transdermal penetration mechanism of ketoprofen nanoparticles

Nagai, N., Ogata, F., Ishii, M., Fukuoka, Y., Otake, H., Nakazawa, Y. & Kawasaki, N., 2018 Jul 23, In : International Journal of Molecular Sciences. 19, 7, 2138.

Research output: Contribution to journalArticle

Ketoprofen
Endocytosis
Nanoparticles
Skin
penetration
4 Citations (Scopus)

LAT1-targeting thermoresponsive fluorescent polymer probes for cancer cell imaging

Matsuura, M., Ohshima, M., Hiruta, Y., Nishimura, T., Nagase, K. & Kanazawa, H., 2018 Jun 1, In : International Journal of Molecular Sciences. 19, 6, 1646.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
transporter
Fluorescent Dyes
amino acids
Amino acids
15 Citations (Scopus)

Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury

Okubo, K., Kurosawa, M., Kamiya, M., Urano, Y., Suzuki, A., Yamamoto, K., Hase, K., Honma, K., Sasaki, J., Miyauchi, H., Hoshino, T., Hayashi, M., Mayadas, T. N. & Hirahashi, J., 2018 Feb 1, In : Nature Medicine. 24, 2, p. 232-238 7 p.

Research output: Contribution to journalArticle

Rhabdomyolysis
Macrophages
Platelet Activation
Platelets
Acute Kidney Injury
2 Citations (Scopus)

Macrophages switch their phenotype by regulating maf expression during different phases of inflammation

Kikuchi, K., Iida, M., Ikeda, N., Moriyama, S., Hamada, M., Takahashi, S., Kitamura, H., Watanabe, T., Hasegawa, Y., Hase, K., Fukuhara, T., Sato, H., Kobayashi, E. H., Suzuki, T., Yamamoto, M., Tanaka, M. & Asano, K., 2018 Jul 15, In : Journal of Immunology. 201, 2, p. 635-651 17 p.

Research output: Contribution to journalArticle

Macrophages
Inflammation
Phenotype
MafF Transcription Factor
Down-Regulation
5 Citations (Scopus)

Mesenchylmal stem cell culture on poly(N-isopropylacrylamide) hydrogel with repeated thermo-stimulation

Akimoto, A. M., Niitsu, E. H., Nagase, K., Okano, T., Kanazawa, H. & Yoshida, R., 2018 Apr 21, In : International Journal of Molecular Sciences. 19, 4, 1253.

Research output: Contribution to journalArticle

stem cells
Hydrogel
Stem cells
stimulation
Cell culture
1 Citation (Scopus)

Molecular Arrangements of Corannulene and Sumanene in Single-Walled Carbon Nanotubes

Iizumi, Y., Liu, Z., Suenaga, K., Okada, S., Higashibayashi, S., Sakurai, H. & Okazaki, T., 2018 Jan 1, (Accepted/In press) In : ChemNanoMat.

Research output: Contribution to journalArticle

Single-walled carbon nanotubes (SWCN)
Photoluminescence spectroscopy
Molecular orientation
Infrared spectroscopy
Microscopic examination
5 Citations (Scopus)

Molecular determinants of sensitivity or resistance of cancer cells toward sanguinarine

Saeed, M. E. M., Mahmoud, N., Sugimoto, Y., Efferth, T. & Abdel-Aziz, H., 2018 Feb 26, In : Frontiers in Pharmacology. 9, FEB, 136.

Research output: Contribution to journalArticle

Drug Resistance
Neoplasms
Epidermal Growth Factor Receptor
Benzophenanthridines
ATP-Binding Cassette Transporters

Motor neuron heterogeneity and selective vulnerability in ALS

Misawa, H. & Morisaki, Y., 2018 Jan 1, In : Folia Pharmacologica Japonica. 152, 2, p. 64-69 6 p.

Research output: Contribution to journalReview article

Amyotrophic Lateral Sclerosis
Motor Neurons
Osteopontin
Fatigue
Matrix Metalloproteinase 9
34 Citations (Scopus)

MS-based lipidomics of human blood plasma: A community-initiated position paper to develop accepted guidelines

Burla, B., Arita, M., Arita, M., Bendt, A. K., Cazenave-Gassiot, A., Dennis, E. A., Ekroos, K., Han, X., Ikeda, K., Liebisch, G., Lin, M. K., Loh, T. P., Meikle, P. J., Orešič, M., Quehenberger, O., Shevchenko, A., Torta, F., Wakelam, M. J. O., Wheelock, C. E. & Wenk, M. R., 2018 Jan 1, In : Journal of Lipid Research. 59, 10, p. 2001-2017 17 p.

Research output: Contribution to journalArticle

Blood
Guidelines
Plasmas
Lipids
Information Dissemination
1 Citation (Scopus)

Mycobacterium triplex pulmonary disease with acquired macrolide resistance in immunocompetent patients

Matsuda, S., Suzuki, S., Morimoto, K., Aono, A., Nishio, K., Asakura, T., Sasaki, Y., Namkoong, H., Nishimura, T., Ogata, H., Hasegawa, N., Kurashima, A., Ishii, M., Tatsumi, K., Mitarai, S. & Goto, H., 2018 Jun 1, In : Clinical Microbiology and Infection. 24, 6, p. 671-672 2 p.

Research output: Contribution to journalLetter

Macrolides
Mycobacterium
Lung Diseases

Nationwide survey on informed consent and ethical review at hospitals conducting post-marketing studies sponsored by pharmaceutical companies

Urushihara, H., Murakami, Y., Matsui, K. & Tashiroc, S., 2018 Jan 1, In : Yakugaku Zasshi. 138, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

Ethical Review
Marketing
Informed Consent
Pharmaceutical Preparations
Pharmacists
Oxidative stress
Hepatocellular Carcinoma
Oxidative Stress
Antioxidants
Nutrition

Nuclear magnetic resonance approaches for characterizing protein-protein interactions

Toyama, Y., Mase, Y., Kano, H., Yokogawa, M., Osawa, M. & Shimada, I., 2018, Methods in Molecular Biology. Humana Press Inc., Vol. 1684. p. 115-128 14 p. (Methods in Molecular Biology; vol. 1684).

Research output: Chapter in Book/Report/Conference proceedingChapter

Magnetic Resonance Spectroscopy
GTP-Binding Proteins
Proteins
Inwardly Rectifying Potassium Channel
Potassium Channels

Occludin as a functional marker of vascular endothelial cells on tube-forming activity

Kanayasu-Toyoda, T., Ishii-Watabe, A., Kikuchi, Y., Kitagawa, H., Suzuki, H., Tamura, H., Tada, M., Suzuki, T., Mizuguchi, H. & Yamaguchi, T., 2018 Feb 1, In : Journal of Cellular Physiology. 233, 2, p. 1700-1711 12 p.

Research output: Contribution to journalArticle

Occludin
Endothelial cells
Endothelial Cells
Endothelial Progenitor Cells
G2 Phase
1 Citation (Scopus)

Olanzapine plus aprepitant, palonosetron, and dexamethasone for nausea and vomiting in patients with breast cancer receiving anthracycline: A retrospective study

Kawazoe, H., Uozumi, R., Murakami, A., Yamashita, M., Kobayashi-Taguchi, K., Kusakabe, E., Yamasawa, H., Yakushijin, Y., Nakamura, T. & Kamei, Y., 2018 Dec 1, In : Scientific Reports. 8, 1, 16232.

Research output: Contribution to journalArticle

aprepitant
olanzapine
Anthracyclines
Drug Combinations
Nausea
8 Citations (Scopus)

Oral Administration of Porphyromonas gingivalis Alters the Gut Microbiome and Serum Metabolome

Kato, T., Yamazaki, K., Nakajima, M., Date, Y., Kikuchi, J., Hase, K., Ohno, H. & Yamazaki, K., 2018 Oct 17, In : mSphere. 3, 5

Research output: Contribution to journalArticle

Porphyromonas gingivalis
Metabolome
Oral Administration
Periodontal Diseases
Serum
4 Citations (Scopus)

Oral vancomycin versus metronidazole for the treatment of Clostridioides difficile infection: Meta-analysis of randomized controlled trials

Igarashi, Y., Tashiro, S., Enoki, Y., Taguchi, K., Matsumoto, K., Ohge, H., Suzuki, H., Nakamura, A., Mori, N., Morinaga, Y., Yamagishi, Y., Yoshizawa, S., Yanagihara, K., Mikamo, H. & Kunishima, H., 2018 Jan 1, (Accepted/In press) In : Journal of Infection and Chemotherapy.

Research output: Contribution to journalArticle

Metronidazole
Vancomycin
Meta-Analysis
Randomized Controlled Trials
Infection

Paradigm Shift in the Quality of Regional Medical Care: Cooperative Treatment of Onychomycosis

Suzuki, J., Imazu, Y., Yoneta, Y., Yamaura, K. & Uchida, E., 2018 Jan 1, In : Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 138, 5, p. 621-628 8 p.

Research output: Contribution to journalReview article

Onychomycosis
Home Care Services
Community Medicine
Therapeutics
Polypharmacy

Patient-Related Risk Factors for Nausea and Vomiting with Standard Antiemetics in Patients with Breast Cancer Receiving Anthracycline-Based Chemotherapy: A Retrospective Observational Study

Kawazoe, H., Murakami, A., Yamashita, M., Nishiyama, K., Kobayashi-Taguchi, K., Komatsu, S., Aoki, R., Kusakabe, E., Yamasawa, H., Yakushijin, Y., Nakamura, T. & Kamei, Y., 2018 Jan 1, (Accepted/In press) In : Clinical Therapeutics.

Research output: Contribution to journalArticle

Antiemetics
Anthracyclines
Nausea
Vomiting
Observational Studies
Off-Label Use
Psychotropic Drugs
Prescriptions
Japan
Databases
3 Citations (Scopus)

Persistence of oral antidiabetic treatment for type 2 diabetes characterized by drug class, patient characteristics and severity of renal impairment: A Japanese database analysis

Kadowaki, T., Sarai, N., Hirakawa, T., Taki, K., Iwasaki, K. & Urushihara, H., 2018 Jan 1, (Accepted/In press) In : Diabetes, Obesity and Metabolism.

Research output: Contribution to journalArticle

Dipeptidyl-Peptidase IV Inhibitors
Biguanides
Hypoglycemic Agents
Type 2 Diabetes Mellitus
Databases

Pharmacokinetic and pharmacodynamic studies of pregabalin suppositories based on pharmacological research

Yajima, R., Matsumoto, K., Yokono, K., Watabe, Y., Enoki, Y., Taguchi, K., Ise, Y., Katayama, S. & Kizu, J., 2018 Jan 1, (Accepted/In press) In : Journal of Pharmacy and Pharmacology.

Research output: Contribution to journalArticle

Suppositories
Pharmacokinetics
Pharmacology
Research
Terminally Ill
17 Citations (Scopus)
brushes
Brushes
Polymers
Actuators
polymerization
63 Citations (Scopus)

Poly(N-isopropylacrylamide)-based thermoresponsive surfaces provide new types of biomedical applications

Nagase, K., Yamato, M., Kanazawa, H. & Okano, T., 2018 Jan 1, In : Biomaterials. 153, p. 27-48 22 p.

Research output: Contribution to journalReview article

Cell Adhesion
Surface Properties
Cell adhesion
Polymerization
Cell Culture Techniques
1 Citation (Scopus)

Population Pharmacokinetics of Intravenous Busulfan in Japanese Pediatric Patients With Primary Immunodeficiency Diseases

Ishiwata, Y., Nagata, M., Tsuge, K., Takahashi, H., Suzuki, S., Imai, K., Takagi, M., Kanegane, H., Morio, T. & Yasuhara, M., 2018 Mar 1, In : Journal of Clinical Pharmacology. 58, 3, p. 327-331 5 p.

Research output: Contribution to journalArticle

Busulfan
Hematopoietic Stem Cell Transplantation
Pharmacokinetics
Pediatrics
Population
2 Citations (Scopus)

Positive predictive value of ICD-10 codes for acute myocardial infarction in Japan: A validation study at a single center

Ando, T., Ooba, N., Mochizuki, M., Koide, D., Kimura, K., Lee, S. L., Setoguchi, S. & Kubota, K., 2018 Nov 26, In : BMC Health Services Research. 18, 1, 895.

Research output: Contribution to journalArticle

Validation Studies
International Classification of Diseases
Japan
Myocardial Infarction
Diagnosis-Related Groups

Preparation of menisdaurigenin and related compounds

Shirakawa, R., Ishikawa, S., Takahasi, M., Ueno, Y., Uekusa, Y., Narukawa, Y., Sugai, T. & Kiuchi, F., 2018 Jan 1, (Accepted/In press) In : Journal of Natural Medicines.

Research output: Contribution to journalArticle

Stereochemistry
Hydrolysis
Enzymatic hydrolysis
Menispermum
Cocculus
2 Citations (Scopus)

Preventive Effects of Renin-Angiotensin System Inhibitors on Oxaliplatin-induced Peripheral Neuropathy: A Retrospective Observational Study

Uchida, M., Kawazoe, H., Takatori, S., Namba, H., Uozumi, R., Tanaka, A., Kawasaki, H. & Araki, H., 2018 Jan 1, (Accepted/In press) In : Clinical Therapeutics.

Research output: Contribution to journalArticle

oxaliplatin
Peripheral Nervous System Diseases
Renin-Angiotensin System
Observational Studies
Retrospective Studies
1 Citation (Scopus)

Protein kinase C alpha-mediated phosphorylation of PIM-1L promotes the survival and proliferation of acute myeloid leukemia cells

Takami, M., Katayama, K., Noguchi, K. & Sugimoto, Y., 2018 Jan 1, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

Protein Kinase C-alpha
Phosphorylation
Myeloid Cells
Acute Myeloid Leukemia
Protein-Tyrosine Kinases
3 Citations (Scopus)

Protein purification using solid-phase extraction on temperature-responsive hydrogel-modified silica beads

Okubo, K., Ikeda, K., Oaku, A., Hiruta, Y., Nagase, K. & Kanazawa, H., 2018 Jan 1, (Accepted/In press) In : Journal of Chromatography A.

Research output: Contribution to journalArticle

Hydrogel
Solid Phase Extraction
Silicon Dioxide
Purification
Temperature
3 Citations (Scopus)

Proteogenomic Analyses of Cellular Lysates Using a Phenol-Guanidinium Thiocyanate Reagent

Kawashima, Y., Miyata, J., Watanabe, T., Shioya, J., Arita, M. & Ohara, O., 2018 Jan 1, (Accepted/In press) In : Journal of Proteome Research.

Research output: Contribution to journalArticle

Phenol
RNA
Proteins
HEK293 Cells
Neutrophils
4 Citations (Scopus)

Quantitative analysis of the anti-inflammatory activity of orengedokuto II: berberine is responsible for the inhibition of NO production

Oshima, N., Shimizu, T., Narukawa, Y., Hada, N. & Kiuchi, F., 2018 Apr 18, (Accepted/In press) In : Journal of Natural Medicines. p. 1-9 9 p.

Research output: Contribution to journalArticle

Berberine
Scutellaria
Phellodendron
Nitric Oxide
Anti-Inflammatory Agents
4 Citations (Scopus)
Biological Products
Alcohols
Availability
Enantiomers
Chirality