Faculty of Pharmacy

Research Output

2006

Aqueous chromatography system using pH- and temperature-responsive stationary phase with ion-exchange groups

Ayano, E., Nambu, K., Sakamoto, C., Kanazawa, H., Kikuchi, A. & Okano, T., 2006 Jun 30, In : Journal of Chromatography A. 1119, 1-2, p. 58-65 8 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Aqueous chromatography system using temperature-reponsive polymer-modified stationary phases

Ayano, E. & Kanazawa, H., 2006 Apr 1, In : Journal of Separation Science. 29, 6, p. 738-749 12 p.

Research output: Contribution to journalReview article

52 Citations (Scopus)

A retrospective study of the relationship between methotrexate clearance and hyperuricemia following high-dose methotrexate therapy

Shibayama, Y., Yoshikawa, Y., Matsumoto, K., Shimodozono, Y., Miyagoe, T., Kurita, M., Kusadome, C., Yamaguchi, M., Nishi, Y., Motoya, T., Takeda, Y. & Yamada, K., 2006 Dec 1, In : Journal of Applied Therapeutic Research. 6, 1, p. 3-6 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Association of hypoadiponectinemia in men with early onset of coronary heart disease and multiple coronary artery stenoses

Hashimoto, N., Kanda, J., Nakamura, T., Horie, A., Kurosawa, H., Hashimoto, T., Sato, K., Kushida, S., Suzuki, M., Yano, S., Iwai, R., Takahashi, H. & Yoshida, S., 2006 Dec 1, In : Metabolism: clinical and experimental. 55, 12, p. 1653-1657 5 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

A T3587G germ-line mutation of the MDR1 gene encodes a nonfunctional P-glycoprotein

Mutoh, K., Mitsuhashi, J., Kimura, Y., Tsukahara, S., Ishikawa, E., Sai, K., Ozawa, S., Sawada, J. I., Ueda, K., Katayama, K. & Sugimoto, Y., 2006 Apr 1, In : Molecular cancer therapeutics. 5, 4, p. 877-884 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

ATP-binding cassette transporter G2 mediates the efflux of phototoxins on the luminal membrane of retinal capillary endothelial cells

Asashima, T., Hori, S., Ohtsuki, S., Tachikawa, M., Watanabe, M., Mukai, C., Kitagaki, S., Miyakoshi, N. & Terasaki, T., 2006 Jun 1, In : Pharmaceutical research. 23, 6, p. 1235-1242 8 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Autophagic degradation of unfolding proteins

Kimura, S., Kamimoto, T. & Yoshimori, T., 2006 Aug 1, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.. 51, 10 Suppl, p. 1494-1498 5 p.

Research output: Contribution to journalReview article

Bioactive lysophospholipid signaling and amino acid metabolism: Studies using genetically-modified mice

Ishii, I., 2006 Jan 1, In : Kitakanto Medical Journal. 56, 4, p. 347-348 2 p.

Research output: Contribution to journalComment/debate

Open Access

Bioorganic studies on plant movement, from natural products to its receptor

Shoji, M., Kato, E., Nakamura, Y., Fujii, T., Manabe, Y. & Ueda, M., 2006 Dec 1, In : Chemical Record. 6, 6, p. 344-355 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

C/EBPα inactivation in FAK-overexpressed HL-60 cells impairs cell differentiation

Hashimoto, K. I., Sonoda, Y., Yamakado, M., Funakoshi-Tago, M., Yoshida, N., Rokudai, A., Aizu-Yokota, E. & Kasahara, T., 2006 Jul 1, In : Cellular Signalling. 18, 7, p. 955-963 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Carrier-mediated hepatic uptake of a novel nonrenal excretion type uric acid generation inhibitor, Y-700

Sai, Y., Kato, Y., Nakamura, K., Kato, S., Nishimura, T., Kubo, Y., Tamai, I., Yang, S., Hu, Z., Yamada, I. & Tsuji, A., 2006 Feb, In : Journal of Pharmaceutical Sciences. 95, 2, p. 336-347 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

CD300 antigen like family member G: A novel Ig receptor like protein exclusively expressed on capillary endothelium

Takatsu, H., Hase, K., Ohmae, M., Ohshima, S., Hashimoto, K., Taniura, N., Yamamoto, A. & Ohno, H., 2006 Sep 15, In : Biochemical and Biophysical Research Communications. 348, 1, p. 183-191 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Celecoxib upregulates endoplasmic reticulum chaperones that inhibit celecoxib-induced apoptosis in human gastric cells

Tsutsumi, S., Namba, T., Tanaka, K. I., Arai, Y., Ishihara, T., Aburaya, M., Mima, S., Hoshino, T. & Mizushima, T., 2006 Feb 16, In : Oncogene. 25, 7, p. 1018-1029 12 p.

Research output: Contribution to journalArticle

105 Citations (Scopus)

Change of the blood concentration of tacrolimus after the switch from fluconazole to voriconazole in patients receiving allogeneic hematopoietic stem cell transplantation

Kawazoe, H., Takiguchi, Y., Tanaka, H., Fukuoka, N., Ohnishi, H., Ishida, T. & Houchi, H., 2006 Dec 1, In : Biological and Pharmaceutical Bulletin. 29, 12, p. 2528-2531 4 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
11 Citations (Scopus)

Circular dichroism in a chiral amide possessing an achiral binaphthyl chromophore

Hosoi, S., Serata, J., Sakushima, A., Kiuchi, F., Takahashi, I. & Ohta, T., 2006 Jan 1, In : Letters in Organic Chemistry. 3, 1, p. 58-61 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Clinical benefit of HCV core antigen assay in patients receiving interferon and ribavirin combination therapy

Higashimoto, M., Takahashi, M., Jokyu, R. & Saito, H., 2006 Feb, In : Rinsho byori. The Japanese journal of clinical pathology. 54, 2, p. 111-115 5 p.

Research output: Contribution to journalArticle

Clofibrate-induced apoptosis is mediated by Ca2+-dependent caspase-12 activation

Matzno, S., Yasuda, S., Kitada, Y., Akiyoshi, T., Tanaka, N., Juman, S., Shinozuka, K., Nakabayashi, T. & Matsuyama, K., 2006 Mar 13, In : Life Sciences. 78, 16, p. 1892-1899 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Combined proline-surfactant organocatalyst for the highly diastereo- and enantioselective aqueous direct cross-aldol reaction of aldehydes

Hayashi, Y., Aratake, S., Okano, T., Takahashi, J., Sumiya, T. & Shoji, M., 2006 Aug 18, In : Angewandte Chemie - International Edition. 45, 33, p. 5527-5529 3 p.

Research output: Contribution to journalArticle

255 Citations (Scopus)

Computational study on the reaction mechanism of the key thermal [4 + 4] cycloaddition reaction in the biosynthesis of epoxytwinol A

Shiina, I., Uchimaru, T., Shoji, M., Kakeya, H., Osada, H. & Hayashi, Y., 2006 Mar 16, In : Organic Letters. 8, 6, p. 1041-1044 4 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Concise enantio- and diastereoselective total syntheses of fumagillol, RK-805, FR65814, ovalicin, and 5-demethylovalicin

Yamaguchi, J., Toyoshima, M., Shoji, M., Kakeya, H., Osada, H. & Hayashi, Y., 2006 Jan 23, In : Angewandte Chemie - International Edition. 45, 5, p. 789-793 5 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Conditional knockout of Mn superoxide dismutase in postnatal motor neurons reveals resistance to mitochondrial generated superoxide radicals

Misawa, H., Nakata, K., Matsuura, J., Moriwaki, Y., Kawashima, K., Shimizu, T., Shirasawa, T. & Takahashi, R., 2006 Jul 1, In : Neurobiology of Disease. 23, 1, p. 169-177 9 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Continuous depolarization induces choline acetyltransferase activity in septal and hippocampal co-cultured embryonic rat neurons

Suzuki, T. & Shimotohno, K., 2006 Feb 6, In : Neuroscience Letters. 394, 1, p. 79-81 3 p.

Research output: Contribution to journalArticle

Cyclooxygenase-2 inhibitor and interferon-β synergistically induce apoptosis in human hepatoma cells in vitro and in vivo

Nakamoto, N., Higuchi, H., Kanamori, H., Kurita, S., Tada, S., Takaishi, H., Toda, K., Yamada, T., Kumagai, N., Saito, H. & Hibi, T., 2006 Sep 1, In : International journal of oncology. 29, 3, p. 625-635 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Demographic, epidemiological, and virological characteristics of hepatitis E virus infections in Japan based on 254 human cases collected nationwide

Abe, T., Aikawa, T., Akahane, Y., Arai, M., Asahina, Y., Atarashi, Y., Chayama, K., Harada, H., Hashimoto, N., Hori, A., Ichida, T., Ikeda, H., Ishikawa, A., Ito, T., Kang, J. H., Karino, Y., Kato, H., Kato, M., Kawakami, M., Kitajima, N. & 25 others, Kitamura, T., Masaki, N., Matsubayashi, K., Matsuda, H., Matsui, A., Michitaka, K., Mihara, H., Miyaji, K., Miyakawa, H., Mizuo, H., Mochida, S., Moriyama, M., Nishiguchi, S., Okada, K., Saito, H., Sakugawa, H., Shibata, M., Suzuki, K., Takahashi, K., Yamada, G., Yamamoto, K., Yamanaka, T., Yamato, H., Yano, K. & Mishiro, S., 2006 Dec 1, In : Acta Hepatologica Japonica. 47, 8, p. 384-391 8 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Development of the measures to evaluate the similarity of drug brand names

Ohtani, H., Takeda, M., Imada, Y. & Sawada, Y., 2006 May 1, In : Yakugaku Zasshi. 126, 5, p. 349-356 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Different effects of fluvoxamine on rabeprazole pharmacokinetics in relation to CYP2C19 genotype status

Uno, T., Shimizu, M., Yasui-Furukori, N., Sugawara, K. & Tateishi, T., 2006 Mar 1, In : British journal of clinical pharmacology. 61, 3, p. 309-314 6 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Differential induction of cystathionine γ-lyase in the livers and kidneys of mouse dams during gestation and lactation

Akahoshi, N., Izumi, T., Ishizaki, Y. & Ishii, I., 2006 Sep 12, In : Biological and Pharmaceutical Bulletin. 29, 9, p. 1799-1802 4 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Differential regulation of eotaxin-1/CCL11 and eotaxin-3/CCL26 production by the TNF-α and IL-4 stimulated human lung fibroblast

Rokudai, A., Terui, Y., Kuniyoshi, R., Mishima, Y., Mishima, Y., Aizu-Yokota, E., Sonoda, Y., Kasahara, T. & Hatake, K., 2006 Jun 1, In : Biological and Pharmaceutical Bulletin. 29, 6, p. 1102-1109 8 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments

Hasegawa, M., Yang, K., Hashimoto, M., Park, J. H., Kim, Y. G., Fujimoto, Y., Nuñez, G., Fukase, K. & Inohara, N., 2006 Sep 29, In : Journal of Biological Chemistry. 281, 39, p. 29054-29063 10 p.

Research output: Contribution to journalArticle

118 Citations (Scopus)

Dissecting Ascaris glycosphingolipids for immunomodulatory moieties - The use of synthetic structural glycosphingolipid analogues

Kean, D. E., Ohtsuka, I., Sato, K., Hada, N., Takeda, T., Lochnit, G., Geyer, R., Harnett, M. M. & Harnett, W., 2006 Mar 1, In : Parasite Immunology. 28, 3, p. 69-76 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Distal colorectal cancers with microsatellite instability (MSI) display distinct gene expression profiles that are different from proximal MSI cancers

Watanabe, T., Kobunai, T., Toda, E., Yamamoto, Y., Kanazawa, T., Kazama, Y., Tanaka, J., Tanaka, T., Konishi, T., Okayama, Y., Sugimoto, Y., Oka, T., Sasaki, S., Muto, T. & Nagawa, H., 2006 Oct 15, In : Cancer Research. 66, 20, p. 9804-9808 5 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Dosage adjustment of quinolone antibiotics and angiotensin-converting enzyme inhibitors in patients with renal dysfunction

Ohtani, H., Kinoshita, Y., Nagasaki, Y., Sata, H., Miki, A., Tsujimoto, M. & Sawada, Y., 2006 Sep, In : International Journal of Clinical Pharmacology and Therapeutics. 44, 9, p. 428-437 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Effect of fluoroquinolones on plasma glucose levels in fasted and glucose-loaded mice

Hori, S., Kizu, J. & Kawamura, M., 2006 Apr, In : Journal of Infection and Chemotherapy. 12, 2, p. 109-111 3 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Effects of 2′-demethoxy-2′-propoxygriseofulvin on microtubule distribution in Chinese hamster V79 cells

Oda, T., 2006 Feb 1, In : Journal of Antibiotics. 59, 2, p. 114-116 3 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Effects of bistheonellide A, an actin-polymerization inhibitor, on Chinese hamster V79 cells and on IL-8 production in PMA-stimulated HL-60 cells

Oda, T., Xu, J., Fujita, A., Mochizuki, M. & Namikoshi, M., 2006 Mar 1, In : Marine Drugs. 4, 1, p. 22-27 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Effects of clarithromycin and verapamil on rabeprazole pharmacokinetics between CYP2C19 genotypes

Shimizu, M., Uno, T., Yasui-Furukori, N., Sugawara, K. & Tateishi, T., 2006 Aug 1, In : European Journal of Clinical Pharmacology. 62, 8, p. 597-603 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Effects of graft densities and chain lengths on separation of bioactive compounds on nanolayered thermoresponsive polymer grafted surfaces

Nagase, K., Kobayashi, J., Kikuchi, A., Kanazawa, H. & Okano, T., 2006 Oct 19. 1 p.

Research output: Contribution to conferencePaper

Effects of herbal extracts on the function of human organic anion-transporting polypeptide OATP-B

Fuchikami, H., Satoh, H., Tsujimoto, M., Ohdo, S., Ohtani, H. & Sawada, Y., 2006 Apr 1, In : Drug Metabolism and Disposition. 34, 4, p. 577-582 6 p.

Research output: Contribution to journalArticle

111 Citations (Scopus)

Effects of itraconazole and diltiazem on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein

Shimizu, M., Uno, T., Sugawara, K. & Tateishi, T., 2006 May 1, In : British journal of clinical pharmacology. 61, 5, p. 538-544 7 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Effects of lissoclibadins and lissoclinotoxins, isolated from a tropical ascidian Lissoclinum cf. badium, on IL-8 production in a PMA-stimulated promyelocytic leukemia cell line

Oda, T., Fujiwara, T., Liu, H., Ukai, K., Mangindaan, R. E. P., Mochizuki, M. & Namikoshi, M., 2006 Mar 1, In : Marine Drugs. 4, 1, p. 15-21 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Effects of single and multiple doses of itraconazole on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein

Shimizu, M., Uno, T., Sugawara, K. & Tateishi, T., 2006 Sep 1, In : British journal of clinical pharmacology. 62, 3, p. 372-376 5 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Efficacy of natural BALL-1 interferon-α treatment for patients with chronic hepatitis C and a possible enhancing effect of a twice-daily starting regimen with interferon-β

Ebinuma, H., Saito, H., Tada, S., Nakamoto, N., Kurita, S., Kitamaura, K., Horikawa, H., Kumagai, N., Tsuchimoto, K., Ishii, H. & Hibi, T., 2006 Jan 1, In : Hepato-gastroenterology. 53, 67, p. 94-99 6 p.

Research output: Contribution to journalArticle

Enantio- and diastereoselective total synthesis of (+)-panepophenanthrin, a ubiquitin-activating enzyme inhibitor, and biological properties of its new derivatives

Matsuzawa, M., Kakeya, H., Yamaguchi, J., Shoji, M., Onose, R., Osada, H. & Hayashi, Y., 2006 Dec 1, In : Chemistry - An Asian Journal. 1, 6, p. 845-851 7 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Enantioselective ene reaction of cyclopentadiene and α,β-enals catalyzed by a diphenylprolinol silyl ether

Gotoh, H., Masui, R., Ogino, H., Shoji, M. & Hayashi, Y., 2006 Oct 20, In : Angewandte Chemie - International Edition. 45, 41, p. 6853-6856 4 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Epigenetic activation of tumor suppressor microRNAs in human cancer cells

Saito, Y. & Jones, P. A., 2006 Oct 1, In : Cell Cycle. 5, 19, p. 2220-2222 3 p.

Research output: Contribution to journalShort survey

Open Access
217 Citations (Scopus)

Epithelial cells as sentinels in mucosal immune barrier

Hase, K. & Ohno, H., 2006 Jan 1, In : Japanese Journal of Clinical Immunology. 29, 1, p. 16-26 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Establishment and characterization of conditionally immortalized endothelial cell lines from the thoracic duct and inferior vena cava of tsA58/EGFP double-transgenic rats

Matsuo, M., Koizumi, K., Yamada, S., Tomi, M., Takahashi, R. I., Ueda, M., Terasaki, T., Obinata, M., Hosoya, K. I., Ohtani, O. & Saiki, I., 2006 Dec 1, In : Cell and Tissue Research. 326, 3, p. 749-758 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Establishment and pathophysiological characterization of type 2 diabetic mouse model produced by streptozotocin and nicotinamide

Nakamura, T., Terajima, T., Ogata, T., Ueno, K., Hashimoto, N., Ono, K. & Yano, S., 2006 Jun 1, In : Biological and Pharmaceutical Bulletin. 29, 6, p. 1167-1174 8 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Estrogen-mediated post transcriptional down-regulation of P-glycoprotein in MDR1-transduced human breast cancer cells

Mutoh, K., Tsukahara, S., Mitsuhashi, J., Katayama, K. & Sugimoto, Y., 2006 Nov 1, In : Cancer science. 97, 11, p. 1198-1204 7 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)