Faculty of Pharmacy

Research Output 1975 2020

2018
3 Citations (Scopus)

Protein purification using solid-phase extraction on temperature-responsive hydrogel-modified silica beads

Okubo, K., Ikeda, K., Oaku, A., Hiruta, Y., Nagase, K. & Kanazawa, H., 2018 Jan 1, (Accepted/In press) In : Journal of Chromatography A.

Research output: Contribution to journalArticle

Hydrogel
Solid Phase Extraction
Silicon Dioxide
Purification
Temperature
3 Citations (Scopus)

Proteogenomic Analyses of Cellular Lysates Using a Phenol-Guanidinium Thiocyanate Reagent

Kawashima, Y., Miyata, J., Watanabe, T., Shioya, J., Arita, M. & Ohara, O., 2018 Jan 1, (Accepted/In press) In : Journal of Proteome Research.

Research output: Contribution to journalArticle

Phenol
RNA
Proteins
HEK293 Cells
Neutrophils
4 Citations (Scopus)

Quantitative analysis of the anti-inflammatory activity of orengedokuto II: berberine is responsible for the inhibition of NO production

Oshima, N., Shimizu, T., Narukawa, Y., Hada, N. & Kiuchi, F., 2018 Apr 18, (Accepted/In press) In : Journal of Natural Medicines. p. 1-9 9 p.

Research output: Contribution to journalArticle

Berberine
Scutellaria
Phellodendron
Nitric Oxide
Anti-Inflammatory Agents
5 Citations (Scopus)
Biological Products
Alcohols
Availability
Enantiomers
Chirality
5 Citations (Scopus)

Reduction of lipid accumulation rescues Bietti's crystalline dystrophy phenotypes

Hata, M., Ikeda, H. O., Iwai, S., Iida, Y., Gotoh, N., Asaka, I., Ikeda, K., Isobe, Y., Hori, A., Nakagawa, S., Yamato, S., Arita, M., Yoshimura, N. & Tsujikawa, A., 2018 Jan 1, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 15, p. 3936-3941 6 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Phenotype
Lipids
Induced Pluripotent Stem Cells
Glucosylceramides
1 Citation (Scopus)

Reelin deficiency leads to aberrant lipid composition in mouse brain

Mizukami, T., Ikeda, K., Shimanaka, Y., Korogi, K., Zhou, C., Takase, H., Tsuiji, H., Kono, N., Kohno, T., Arai, H., Arita, M. & Hattori, M., 2018 Oct 20, In : Biochemical and Biophysical Research Communications. 505, 1, p. 81-86 6 p.

Research output: Contribution to journalArticle

Stearoyl-CoA Desaturase
Brain
Phospholipids
Lipids
Docosahexaenoic Acids

Relationship between medication adherence and glycemic control in Japanese patients with type 2 diabetes

Tominaga, Y., Aomori, T., Hayakawa, T., Morisky, D. E., Takahashi, K. & Mochizuki, M., 2018 Jan 1, In : Pharmazie. 73, 10, p. 609-612 4 p.

Research output: Contribution to journalArticle

Medication Adherence
Type 2 Diabetes Mellitus
Glycosylated Hemoglobin A
Multivariate Analysis
Cross-Sectional Studies
4 Citations (Scopus)

Repurposing of bromocriptine for cancer therapy

Seo, E. J., Sugimoto, Y., Greten, H. J. & Efferth, T., 2018 Oct 8, In : Frontiers in Pharmacology. 9, OCT, 1030.

Research output: Contribution to journalArticle

Bromocriptine
Neoplasms
Therapeutics
Pharmaceutical Preparations
Cell Line

Risk Factor for Diabetes Mellitus and High Blood Glucose With HMG-CoA Reductase Inhibitors Using a Postmarketing Surveillance Database in Japan

Hashiguchi, M., Maruyama, J., Shimizu, M., Takahashi, D. & Shiga, T., 2018 Jan 1, (Accepted/In press) In : Clinical Pharmacology in Drug Development.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Blood Glucose
Diabetes Mellitus
Japan
Databases
1 Citation (Scopus)

Risk factors associated with pseudoaldosteronism in patients with chronic hepatitis: A retrospective cohort study

Komatsu, A., Yoshino, T., Suzuki, T., Nakamura, T., Kanai, T. & Watanabe, K., 2018 Jan 1, (Accepted/In press) In : Basic and Clinical Pharmacology and Toxicology.

Research output: Contribution to journalArticle

Liddle Syndrome
Glycyrrhizic Acid
Chronic Hepatitis
Cohort Studies
Retrospective Studies

Risk factors for hyperuricemia with HMG-CoA reductase inhibitors using a postmarketing surveillance database in Japan

Hashiguchi, M., Hakamata, J., Shimizu, M., Maruyama, J., Shiga, T. & Mochizuki, M., 2018 Jan 1, In : Japanese Journal of Clinical Pharmacology and Therapeutics. 49, 4, p. 145-150 6 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hyperuricemia
Japan
Databases
Uric Acid

Risk factors for rhabdomyolysis with HMG-CoA reductase inhibitors identified using a postmarketing surveillance database in Japan

Hashiguchi, M., Hakamata, J., Shimizu, M., Maruyama, J., Shiga, T. & Mochizuki, M., 2018 Jan 1, In : International Journal of Clinical Pharmacology and Therapeutics. 56, 7, p. 310-320 11 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Rhabdomyolysis
Japan
Databases
Angiotensin Receptor Antagonists
3 Citations (Scopus)

Roasted Coffee Reduces β-Amyloid Production by Increasing Proteasomal β-Secretase Degradation in Human Neuroblastoma SH-SY5Y Cells

Fukuyama, K., Kakio, S., Nakazawa, Y., Kobata, K., Tago, M., Suzuki, T. & Tamura, H., 2018 Jan 1, (Accepted/In press) In : Molecular Nutrition and Food Research.

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Coffee
roasting
amyloid
pyrocatechol

Role of Pharmacists in Topical Therapy for Onychomycosis in the Home-care Setting

Yamaura, K., Hayashi, N., Imazu, Y., Yoneta, Y., Uchida, E. & Suzuki, J., 2018 Jan 1, In : Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 138, 5, p. 615-619 5 p.

Research output: Contribution to journalArticle

Onychomycosis
Home Care Services
Nails
Pharmacists
Tinea

SIMPLE binds specifically to PI4P through SIMPLE-like domain and participates in protein trafficking in the trans-Golgi network and/or recycling endosomes

Moriwaki, Y., Ohno, Y., Ishii, T., Takamura, Y., Kita, Y., Watabe, K., Sango, K., Tsuji, S. & Misawa, H., 2018 Jun 1, In : PLoS One. 13, 6, e0199829.

Research output: Contribution to journalArticle

trans-Golgi Network
endosomes
protein transport
Endosomes
lysosomes

Stability of benzylpenicillin potassium and ampicillin in an elastomeric infusion pump

Nakamura, T., Enoki, Y., Uno, S., Uwamino, Y., Iketani, O., Hasegawa, N. & Matsumoto, K., 2018 Jan 1, (Accepted/In press) In : Journal of Infection and Chemotherapy.

Research output: Contribution to journalArticle

Infusion Pumps
Penicillin G
Ampicillin
Acetates
Anti-Infective Agents
3 Citations (Scopus)

Stereoselective Total Synthesis of Macrophage-Produced Prohealing 14,21-Dihydroxy Docosahexaenoic Acids

Nishimura, K., Sakaguchi, T., Nanba, Y., Suganuma, Y., Morita, M., Hong, S., Lu, Y., Jun, B., Bazan, N. G., Arita, M. & Kobayashi, Y., 2018 Jan 5, In : Journal of Organic Chemistry. 83, 1, p. 154-166 13 p.

Research output: Contribution to journalArticle

Docosahexaenoic Acids
Macrophages
Aldehydes
Nitriles
Lactic Acid
5 Citations (Scopus)
Inwardly Rectifying Potassium Channel
GTP-Binding Proteins
Nuclear magnetic resonance spectroscopy
Ethanol
Neurology

Study of Home-based Ringworm Treatment and Follow-up by Visiting Nurses and Physicians: Interventional Effects

Uchida, E., Imazu, Y., Yoneta, Y., Yamaura, K. & Suzuki, J., 2018 Jan 1, In : Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 138, 5, p. 611-613 3 p.

Research output: Contribution to journalReview article

Tinea
Community Health Nurses
Foot
Physicians
Onychomycosis

Syntheses of Englerin A, a Potent Renal Cancer Inhibitor

Hagihara, S., Hanaya, K., Sugai, T. & Shoji, M., 2018 Jan 1, (Accepted/In press) In : Asian Journal of Organic Chemistry.

Research output: Contribution to journalArticle

Guaiane Sesquiterpenes
Oxygen
Pharmaceutical Preparations
englerin A
hydrazine
Sulfoxides
Heterocyclic Compounds
sulfoxide
Fluorescence
Aldehydes
Steroids
Lewis Acids
Bromides
Lithium
Drug Resistance
Protein Binding
Adenosine Triphosphate
irinotecan
Breast Neoplasms
4 Citations (Scopus)
Quercetin
Molecules
fisetin
naringin

Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation

Ohe, T., Umezawa, R., Kitagawara, Y., Yasuda, D., Takahashi, K., Nakamura, S., Abe, A., Sekine, S., Ito, K., Okunushi, K., Morio, H., Furihata, T., Anzai, N. & Mashino, T., 2018 Jan 1, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Benzbromarone
Uricosuric Agents
Chemical activation
Derivatives
Uric Acid
4 Citations (Scopus)

Synthesis of oroxylin A starting from naturally abundant baicalin

Fujita, R., Hanaya, K., Higashibayashi, S. & Sugai, T., 2018 Jan 1, In : Heterocycles. 97, 2, p. 1165-1174 10 p.

Research output: Contribution to journalArticle

Ether
Sterilizers
Acetylation
Methylation
Glucuronides
2 Citations (Scopus)
Hydrolysis
Sterilizers
2,4-Dichlorophenoxyacetic Acid
Steam
Pressure
8 Citations (Scopus)

Taxodione induces apoptosis in BCR-ABL-positive cells through ROS generation

Uchihara, Y., Tago, K., Taguchi, H., Narukawa, Y., Kiuchi, F., Tamura, H. & Tago, M., 2018 Aug 1, In : Biochemical Pharmacology. 154, p. 357-372 16 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Cells
Apoptosis
Leukemia
K562 Cells
8 Citations (Scopus)

The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques

Nagatake, T., Shiogama, Y., Inoue, A., Kikuta, J., Honda, T., Tiwari, P., Kishi, T., Yanagisawa, A., Isobe, Y., Matsumoto, N., Shimojou, M., Morimoto, S., Suzuki, H., Hirata, S. I., Steneberg, P., Edlund, H., Aoki, J., Arita, M., Kiyono, H., Yasutomi, Y. & 3 others, Ishii, M., Kabashima, K. & Kunisawa, J., 2018 Jan 1, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Contact Dermatitis
Macaca
G-Protein-Coupled Receptors
Neutrophils
Acids
1 Citation (Scopus)
Amlodipine
Charcoal
Drug Interactions
Eating
Pharmaceutical Preparations
3 Citations (Scopus)

Therapeutic effect of vitamin D3-containing nanostructured lipid carriers on inflammatory bowel disease

Zai, K., Hirota, M., Yamada, T., Ishihara, N., Mori, T., Kishimura, A., Suzuki, K., Hase, K. & Katayama, Y., 2018 Sep 28, In : Journal of Controlled Release. 286, p. 94-102 9 p.

Research output: Contribution to journalArticle

Cholecalciferol
Therapeutic Uses
Inflammatory Bowel Diseases
Lipids
Dextran Sulfate

Three new 5,6,7,8-tetrahydroxy-5,6,7,8-tetrahydrochromone derivatives enantiomeric to agarotetrol from agarwood

Sugiyama, T., Narukawa, Y., Shibata, S., Masui, R. & Kiuchi, F., 2018 Mar 10, (Accepted/In press) In : Journal of Natural Medicines. p. 1-8 8 p.

Research output: Contribution to journalArticle

Thymelaeaceae
Type 3 Cyclic Nucleotide Phosphodiesterases
Chromones
Derivatives
Stereochemistry
2 Citations (Scopus)

Thromboxane A2 facilitates IL-17A production from Vγ4+ γδ T cells and promotes psoriatic dermatitis in mice

Ueharaguchi, Y., Honda, T., Kusuba, N., Hanakawa, S., Adachi, A., Sawada, Y., Otsuka, A., Kitoh, A., Dainichi, T., Egawa, G., Nakashima, C., Nakajima, S., Murata, T., Ono, S., Arita, M., Narumiya, S., Miyachi, Y. & Kabashima, K., 2018 Jan 1, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Thromboxane A2
Interleukin-17
Dermatitis
T-Lymphocytes
3 Citations (Scopus)

Transport of Pregabalin Via L-Type Amino Acid Transporter 1 (SLC7A5) in Human Brain Capillary Endothelial Cell Line

Takahashi, Y., Nishimura, T., Higuchi, K., Noguchi, S., Tega, Y., Kurosawa, T., Deguchi, Y. & Tomi, M., 2018 Oct 29, In : Pharmaceutical Research. 35, 12, 1 p.

Research output: Contribution to journalArticle

Large Neutral Amino Acid-Transporter 1
Amino Acid Transport Systems
Endothelial cells
Brain
Endothelial Cells
7 Citations (Scopus)

Triazasumanene: An isoelectronic heteroanalogue of sumanene

Tan, Q., Kaewmati, P., Higashibayashi, S., Kawano, M., Yakiyama, Y. & Sakurai, H., 2018 Jan 1, In : Bulletin of the Chemical Society of Japan. 91, 4, p. 531-537 7 p.

Research output: Contribution to journalArticle

Crystals
Chirality
Optical band gaps
Molecular orbitals
Electronic structure
10 Citations (Scopus)

Tris(2-hydroxyphenyl)triazasumanene: Bowl-shaped excited-state intramolecular proton transfer (ESIPT) fluorophore coupled with aggregation-induced enhanced emission (AIEE)

Kaewmati, P., Yakiyama, Y., Ohtsu, H., Kawano, M., Haesuwannakij, S., Higashibayashi, S. & Sakurai, H., 2018 Jan 1, In : Materials Chemistry Frontiers. 2, 3, p. 514-519 6 p.

Research output: Contribution to journalArticle

Proton transfer
Fluorophores
Excited states
Agglomeration
Single crystals

医師・看護師・薬剤師の連携による地域医療の質の向上―忘れがちな障害,爪白癬の治療を通して―

Translated title of the contribution: Improvement in the quality of regional medical care through the cooperation of physicians, nurses, and pharmacists: Cooperative treatment of undiagnosed onychomycosisImazu, Y., Yoneta, Y., Uchida, E., Yamaura, K. & Suzuki, J., 2018 Jan 1, In : Yakugaku Zasshi. 138, 5, p. 601-605 5 p.

Research output: Contribution to journalArticle

Open Access
Onychomycosis
Quality Improvement
Pharmacists
Nurses
Physicians

粘膜面におけるバリア機能と免疫恒常性の維持に果たす M 細胞の役割

Translated title of the contribution: Intestinal M cells contribute to the maintenance of mucosal barrier functions and immune homeostasisIshihara, N., Kobayashi, N. & Hase, K., 2018 Jan 1, In : Japanese Journal of Allergology. 67, 3, p. 171-178 8 p.

Research output: Contribution to journalArticle

Homeostasis
Maintenance
2017
6 Citations (Scopus)

12-OH-17,18-Epoxyeicosatetraenoic acid alleviates eosinophilic airway inflammation in murine lungs

Mochimaru, T., Fukunaga, K., Miyata, J., Matsusaka, M., Masaki, K., Kabata, H., Ueda, S., Suzuki, Y., Goto, T., Urabe, D., Inoue, M., Isobe, Y., Arita, M. & Betsuyaku, T., 2017, (Accepted/In press) In : Allergy: European Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Eicosapentaenoic Acid
Inflammation
Lung
Acids
Eosinophils
9 Citations (Scopus)

Aberrant DNA methylation as a biomarker and a therapeutic target of cholangiocarcinoma

Nakaoka, T., Saito, Y. & Saito, H., 2017 Jun 1, In : International Journal of Molecular Sciences. 18, 6, 1111.

Research output: Contribution to journalReview article

tumor suppressor genes
methylation
Cholangiocarcinoma
biomarkers
Biomarkers
4 Citations (Scopus)

Administration of antioxidant compounds affects the lens chaperone activity and prevents the onset of cataracts

Nakazawa, Y., Nagai, N., Ishimori, N., Oguchi, J. & Tamura, H., 2017 Nov 1, In : Biomedicine and Pharmacotherapy. 95, p. 137-143 7 p.

Research output: Contribution to journalArticle

Cataract
Lenses
Antioxidants
Crystallins
Coffee
7 Citations (Scopus)

Alpha-tocopherol attenuates the anti-tumor activity of crizotinib against cells transformed by NPM-ALK

Uchihara, Y., Ueda, F., Tago, K., Nakazawa, Y., Ohe, T., Mashino, T., Yokota, S., Kasahara, T., Tamura, H. & Tago, M., 2017 Aug 1, In : PLoS One. 12, 8, e0183003.

Research output: Contribution to journalArticle

alpha-Tocopherol
lymphoma
alpha-tocopherol
Tumors
phosphotransferases (kinases)
10 Citations (Scopus)

A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis

Anzai, I., Tokuda, E., Mukaiyama, A., Akiyama, S., Endo, F., Yamanaka, K., Misawa, H. & Furukawa, Y., 2017 Mar 1, In : Protein Science. 26, 3, p. 484-496 13 p.

Research output: Contribution to journalArticle

Oligomerization
Amyotrophic Lateral Sclerosis
Disulfides
Dimers
Oligomers
2 Citations (Scopus)

A mouse model reveals that Mfsd2a is critical for unfolded protein response upon exposure to tunicamycin

Moritake, H., Obara, M., Saito, Y., Kashimada, A., Takagi, M., Tago, M., Fukuyama, T., Yoshioka, M., Inoue, A., Komatsu, H., Nishitoh, H., Kataoka, H. & Nunoi, H., 2017 Apr 1, In : Human Cell. 30, 2, p. 88-97 10 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Tunicamycin
Thapsigargin
Docosahexaenoic Acids
Hypersensitivity
terbinafine
Nortriptyline
Amitriptyline
Drug Interactions
Tricyclic Antidepressive Agents
6 Citations (Scopus)

A nanoparticle-based ophthalmic formulation of dexamethasone enhances corneal permeability of the drug and prolongs its corneal residence time

Nagai, N., Nakazawa, Y., Ito, Y., Kanai, K., Okamoto, N. & Shimomura, Y., 2017, In : Biological and Pharmaceutical Bulletin. 40, 7, p. 1055-1062 8 p.

Research output: Contribution to journalArticle

Nanoparticles
Dexamethasone
Permeability
Pharmaceutical Preparations
Parabens
3 Citations (Scopus)

An empirical study of the prescription pattern of drugs for hematological malignancies in Japan from 2010-2014

Shibata, S., Wayama, Y., Tsuyuki, A., Matsushita, M., Chiba, K., Matsuki, E., Okamoto, S. & Suzuki, T., 2017, In : Biological and Pharmaceutical Bulletin. 40, 6, p. 894-901 8 p.

Research output: Contribution to journalArticle

Prescription Drugs
Hematologic Neoplasms
Japan
Pharmaceutical Preparations
Pharmaceutical Databases
1 Citation (Scopus)

A novel phenylphthalimide derivative, pegylated TC11, improves pharmacokinetic properties and induces apoptosis of high-risk myeloma cells via G2/M cell-cycle arrest

Aida, S., Hozumi, M., Ichikawa, D., Iida, K., Yonemura, Y., Tabata, N., Yamada, T., Matsushita, M., Sugai, T., Yanagawa, H. & Hattori, Y., 2017, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

G2 Phase Cell Cycle Checkpoints
Pharmacokinetics
Multiple Myeloma
Polyethylene glycols
Cells
20 Citations (Scopus)

APC mutations as a potential biomarker for sensitivity to tankyrase inhibitors in colorectal cancer

Tanaka, N., Mashima, T., Mizutani, A., Sato, A., Aoyama, A., Gong, B., Yoshida, H., Muramatsu, Y., Nakata, K., Matsuura, M., Katayama, R., Nagayama, S., Fujita, N., Sugimoto, Y. & Seimiya, H., 2017 Apr 1, In : Molecular Cancer Therapeutics. 16, 4, p. 752-762 11 p.

Research output: Contribution to journalArticle

Tankyrases
Catenins
Adenomatous Polyposis Coli
Colorectal Neoplasms
Biomarkers
20 Citations (Scopus)

ARIH2 ubiquitinates NLRP3 and negatively regulates NLRP3 inflammasome activation in macrophages

Kawashima, A., Karasawa, T., Tago, K., Kimura, H., Kamata, R., Usui-Kawanishi, F., Watanabe, S., Ohta, S., Tago, M., Yanagisawa, K., Kasahara, T., Suzuki, K. & Takahashi, M., 2017 Nov 15, In : Journal of Immunology. 199, 10, p. 3614-3622 9 p.

Research output: Contribution to journalArticle

Inflammasomes
Macrophage Activation
Ubiquitination
Clustered Regularly Interspaced Short Palindromic Repeats
Caspase 1