Faculty of Pharmacy

Research Output 1975 2020

2017
4 Citations (Scopus)
Terpenes
Lipases
carboxylates
hydrolysis
acetates
8 Citations (Scopus)

Cluster microRNAs miR-194 and miR-215 suppress the tumorigenicity of intestinal tumor organoids

Nakaoka, T., Saito, Y., Shimamoto, Y., Muramatsu, T., Kimura, M., Kanai, Y. & Saito, H., 2017 Apr 1, In : Cancer Science. 108, 4, p. 678-684 7 p.

Research output: Contribution to journalArticle

Organoids
Neoplasms
MicroRNAs
Neoplastic Stem Cells
Intestinal Mucosa
13 Citations (Scopus)

Coffee extract inhibits adipogenesis in 3T3-L1 preadipocyes by interrupting insulin signaling through the downregulation of IRS1

Maki, C., Tago, M., Aoyagi, R., Ueda, F., Kimura, M., Kobata, K., Tago, K. & Tamura, H., 2017 Mar 1, In : PLoS One. 12, 3, e0173264.

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Adipogenesis
Coffee
insulin
Down-Regulation
5 Citations (Scopus)

Coffee reduces KRAS expression in Caco-2 human colon carcinoma cells via regulation of miRNAs

Nakayama, T., Tago, M. & Tamura, H., 2017, In : Oncology Letters. 14, 1, p. 1109-1114 6 p.

Research output: Contribution to journalArticle

Coffee
MicroRNAs
Colon
Carcinoma
Colonic Neoplasms
5 Citations (Scopus)

Co-instillation of nano-solid magnesium hydroxide enhances corneal permeability of dissolved timolol

Nagai, N., Ogata, F., Otake, H., Kawasaki, N., Nakazawa, Y., Kanai, K., Okamoto, N. & Shimomura, Y., 2017 Dec 1, In : Experimental Eye Research. 165, p. 118-124 7 p.

Research output: Contribution to journalArticle

Magnesium Hydroxide
Timolol
Permeability
Nanoparticles
Particle Size

Co-localization of microsomal prostaglandin E synthase-1 with cyclooxygenase-1 in layer II of murine placental syncytiotrophoblasts

Inagaki, M., Nishimura, T., Akanuma, S. I., Nakanishi, T., Tachikawa, M., Tamai, I., Hosoya, K. I., Nakashima, E. & Tomi, M., 2017 May 1, In : Placenta. 53, p. 174-182 9 p.

Research output: Contribution to journalArticle

Cyclooxygenase 1
Trophoblasts
Prostaglandins E
Placental Circulation
Dinoprostone
17 Citations (Scopus)

Commensal Lactobacillus Controls Immune Tolerance during Acute Liver Injury in Mice

Nakamoto, N., Amiya, T., Aoki, R., Taniki, N., Koda, Y., Miyamoto, K., Teratani, T., Suzuki, T., Chiba, S., Cho, H., Hayashi, A., Yamaguchi, A., Shiba, S., Miyake, R., Katayama, T., Suda, W., Mikami, Y., Kamada, N., Ebinuma, H., Saito, H. & 2 others, Hattori, M. & Kanai, T., 2017 Oct 31, In : Cell Reports. 21, 5, p. 1215-1226 12 p.

Research output: Contribution to journalArticle

Immune Tolerance
Lactobacillus
Liver
Wounds and Injuries
Dendritic Cells
12 Citations (Scopus)

Comprehensive analyses of oxidized phospholipids using a measured MS/MS spectra library

Aoyagi, R., Ikeda, K., Isobe, Y. & Arita, M., 2017, In : Journal of Lipid Research. 58, 11, p. 2229-2237 9 p.

Research output: Contribution to journalArticle

Libraries
Phospholipids
Arteriosclerosis
Macrophages
Peritoneal Macrophages
16 Citations (Scopus)

Comprehensive identification of sphingolipid species by in silico retention time and tandem mass spectral library

Tsugawa, H., Ikeda, K., Tanaka, W., Senoo, Y., Arita, M. & Arita, M., 2017 Mar 15, In : Journal of Cheminformatics. 9, 1, 19.

Research output: Contribution to journalArticle

Sphingolipids
Ceramides
Tissue
computer programs
mice

Construction of 2,6,9,11-tetraoxatricyclo[6.2.1.03,8]undecane containing 4-keto-D-glucose skeleton

Fujitani, B., Hanaya, K., Higashibayashi, S., Shoji, M. & Sugai, T., 2017 Dec 21, In : Tetrahedron. 73, 51, p. 7217-7222 6 p.

Research output: Contribution to journalArticle

Spironolactone
Stereochemistry
Skeleton
Scaffolds
undecane
5 Citations (Scopus)

Contributions of system A subtypes to α-methylaminoisobutyric acid uptake by placental microvillous membranes of human and rat

Takahashi, Y., Nishimura, T., Maruyama, T., Tomi, M. & Nakashima, E., 2017 Feb 4, (Accepted/In press) In : Amino Acids. p. 1-9 9 p.

Research output: Contribution to journalArticle

Rats
Betaine
Membranes
Acids
Arginine
2 Citations (Scopus)

CXorf48 is a potential therapeutic target for achieving treatment-free remission in CML patients

Matsushita, M., Ozawa, K., Suzuki, T., Nakamura, M., Nakano, N., Kanchi, S., Ichikawa, D., Matsuki, E., Sakurai, M., Karigane, D., Kasahara, H., Tsukamoto, N., Shimizu, T., Mori, T., Nakajima, H., Okamoto, S., Kawakami, Y. & Hattori, Y., 2017 Sep 1, In : Blood Cancer Journal. 7, 9, e601.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Stem Cells
Therapeutics
T-Lymphocytes
2 Citations (Scopus)

Data on the effect of hypomyelinating leukodystrophy 6 (HLD6)-associated mutations on the TUBB4A properties

Miyamoto, Y., Torii, T., Kawahara, K., Hasegawa, N., Tanoue, A., Seki, Y., Morimoto, T., Tago, M., Tamura, H., Homma, K., Yamamoto, M. & Yamauchi, J., 2017 Apr 1, In : Data in Brief. 11, p. 284-289 6 p.

Research output: Contribution to journalArticle

Disease
cause
4 Citations (Scopus)
Silicon Dioxide
Nanoparticles
Polymers
Silica
silicon dioxide
3 Citations (Scopus)

Detection of bacterial DNA by in situ hybridization in patients with decompensated liver cirrhosis

Usui, S., Ebinuma, H., Cho, H., Nakamoto, N., Yamagishi, Y., Saito, H. & Kanai, T., 2017 Oct 17, In : BMC Gastroenterology. 17, 1

Research output: Contribution to journalArticle

Bacterial DNA
Liver Cirrhosis
In Situ Hybridization
Peritonitis
Bacteria
7 Citations (Scopus)

Determination of polychlorinated biphenyls in marine fish obtained from tsunami-stricken areas of Japan

Uekusa, Y., Takatsuki, S., Tsutsumi, T., Akiyama, H., Matsuda, R., Teshima, R., Hachisuka, A. & Watanabe, T., 2017 Apr 1, In : PLoS One. 12, 4, e0174961.

Research output: Contribution to journalArticle

Tsunamis
tsunamis
Polychlorinated Biphenyls
polychlorinated biphenyls
marine fish
Pharmacy Students
Japan
Students
Diagnostic Self Evaluation
Pharmacists

Development of a new scholastic program for medication counseling practice in preclinical training, constructed for junior students by senior students based on their experiences of on-site practice

Suzuki, S., Aono, I., Imai, N., Kuwabara, A., Kenda, Y., Matsumoto, M., Yoshida, A., Watanabe, A., Takagi, A., Kobayashi, N., Saeki, H., Ohtani, H., Nakamur, T. & Kizud, J., 2017, In : Yakugaku Zasshi. 137, 11, p. 1391-1408 18 p.

Research output: Contribution to journalArticle

Counseling
Students
Pharmacy Education
Anxiety
Communication
12 Citations (Scopus)

Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor

Yasuda, D., Yuasa, A., Obata, R., Nakajima, M., Takahashi, K., Ohe, T., Ichimura, Y., Komatsu, M., Yamamoto, M., Imamura, R., Kojima, H., Okabe, T., Nagano, T. & Mashino, T., 2017 Nov 15, In : Bioorganic and Medicinal Chemistry Letters. 27, 22, p. 5006-5009 4 p.

Research output: Contribution to journalArticle

Indoles
Proteins
Hydroxamic Acids
Lead compounds
Derivatives
3 Citations (Scopus)

Dissociation of blood-brain barrier disruption and disease manifestation in an aquaporin-4-deficient mouse model of amyotrophic lateral sclerosis

Watanabe-Matsumoto, S., Moriwaki, Y., Okuda, T., Ohara, S., Yamanaka, K., Abe, Y., Yasui, M. & Misawa, H., 2017 Jan 1, (Accepted/In press) In : Neuroscience Research.

Research output: Contribution to journalArticle

Aquaporin 4
Amyotrophic Lateral Sclerosis
Blood-Brain Barrier
Motor Neuron Disease
Gliosis
2 Citations (Scopus)

Dosing optimization of meropenem based on a pharmacokinetic analysis in patients receiving hemodiafiltration and an in vitro model

Yokoyama, Y., Nishino, K., Matsumoto, K., Inomoto, Y., Matsuda, K., Nakamura, R. N., Yasuno, N. & Kizu, J., 2017, (Accepted/In press) In : Journal of Infection and Chemotherapy.

Research output: Contribution to journalArticle

meropenem
Hemodiafiltration
Pharmacokinetics
In Vitro Techniques
Japan
Pharmaceutical Preparations
Generic Drugs
Linear Models
5 Citations (Scopus)

Dual temperature-and pH-responsive polymeric micelle for selective and efficient two-step doxorubicin delivery

Hiruta, Y., Kanda, Y., Katsuyama, N. & Kanazawa, H., 2017, In : RSC Advances. 7, 47, p. 29540-29549 10 p.

Research output: Contribution to journalArticle

Micelles
Doxorubicin
Temperature
Cytotoxicity
Phase transitions
16 Citations (Scopus)

Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses

Toyama, Y., Kano, H., Mase, Y., Yokogawa, M., Osawa, M. & Shimada, I., 2017 Feb 22, In : Nature Communications. 8, 14523.

Research output: Contribution to journalArticle

guanosines
diphosphates
Guanosine
Diphosphates
Magnetic Fields
5 Citations (Scopus)

Effect of everolimus on the glucose metabolic pathway in mouse skeletal muscle cells (C2C12)

Yoshida, K., Imamura, C., Hara, K., Mochizuki, M. & Tanigawara, Y., 2017 Aug 1, In : Metabolomics. 13, 8, 98.

Research output: Contribution to journalArticle

Metabolic Networks and Pathways
Muscle Cells
Muscle
Skeletal Muscle
Cells
15 Citations (Scopus)

Enhanced cellular uptake and gene silencing activity of siRNA using temperature-responsive polymer-modified liposome

Wang, J., Ayano, E., Maitani, Y. & Kanazawa, H., 2017 May 15, In : International Journal of Pharmaceutics. 523, 1, p. 217-228 12 p.

Research output: Contribution to journalArticle

Gene Silencing
Liposomes
Small Interfering RNA
Polymers
Temperature
45 Citations (Scopus)

Expression and function of the cholinergic system in immune cells

Fujii, T., Mashimo, M., Moriwaki, Y., Misawa, H., Ono, S., Horiguchi, K. & Kawashima, K., 2017 Sep 6, In : Frontiers in Immunology. 8, SEP, 1085.

Research output: Contribution to journalReview article

Cholinergic Agents
Immune System
Spleen
Choline O-Acetyltransferase
Acetylcholine
7 Citations (Scopus)

Factorial analysis of hepatitis b virus reactivation-induced hepatitis b using jader

Hara, A., Matsumoto, K., Yokoyama, Y. & Kizu, J., 2017, In : Biological and Pharmaceutical Bulletin. 40, 6, p. 782-788 7 p.

Research output: Contribution to journalArticle

Hepatitis Viruses
Hepatitis B
Hepatitis
Prednisolone
Rheumatoid Arthritis
8 Citations (Scopus)

Formation and spreading of TDP-43 aggregates in cultured neuronal and glial cells demonstrated by time-lapse imaging

Ishii, T., Kawakami, E., Endo, K., Misawa, H. & Watabe, K., 2017 Jun 1, In : PLoS One. 12, 6, e0179375.

Research output: Contribution to journalArticle

Time-Lapse Imaging
DNA-binding proteins
DNA-Binding Proteins
neuroglia
cell aggregates
3 Citations (Scopus)

Fractional laser-assisted percutaneous drug delivery via temperature-responsive liposomes

Fujimoto, T., Ito, M., Ito, S. & Kanazawa, H., 2017 Feb 22, (Accepted/In press) In : Journal of Biomaterials Science, Polymer Edition. p. 1-11 11 p.

Research output: Contribution to journalArticle

Liposomes
Drug delivery
Lasers
Temperature
Pharmaceutical Preparations
8 Citations (Scopus)

Free cholesterol accumulation in liver sinusoidal endothelial cells exacerbates acetaminophen hepatotoxicity via TLR9 signaling

Teratani, T., Tomita, K., Suzuki, T., Furuhashi, H., Irie, R., Hida, S., Okada, Y., Kurihara, C., Ebinuma, H., Nakamoto, N., Saito, H., Hibi, T., Miura, S., Hokari, R. & Kanai, T., 2017, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

Toll-Like Receptor 9
Acetaminophen
Endothelial Cells
Cholesterol
Liver
2 Citations (Scopus)

Functional effects of AKT3 on aurora kinase inhibitorinduced aneuploidy

Noguchi, K., Hongama, K., Hariki, S., Nonomiya, Y., Katayama, K. & Sugimoto, Y., 2017 Feb 3, In : Journal of Biological Chemistry. 292, 5, p. 1910-1924 15 p.

Research output: Contribution to journalArticle

Aurora Kinases
Aneuploidy
HCT116 Cells
Anaphase
Phosphorylation
4 Citations (Scopus)

Guidelines for therapeutic drug monitoring of cardiovascular drugs clinical use of blood drug concentration monitoring (Jcs 2015) ― digest version ―

Japanese Circulation Society & Japanese Society of Therapeutic Drug Monitoring Joint Working Group, 2017, In : Circulation Journal. 81, 4, p. 581-612 32 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice

Yang, J. Y., Lee, Y. S., Kim, Y., Lee, S. H., Ryu, S., Fukuda, S., Hase, K., Yang, C. S., Lim, H. S., Kim, M. S., Kim, H. M., Ahn, S. H., Kwon, B. E., Ko, H. J. & Kweon, M. N., 2017 Jan 1, In : Mucosal Immunology. 10, 1, p. 104-116 13 p.

Research output: Contribution to journalArticle

Bacteroides
Insulin Resistance
Obesity
Bacteria
Adipose Tissue
13 Citations (Scopus)

Gut microbiota-mediated generation of saturated fatty acids elicits inflammation in the liver in murine high-fat diet-induced steatohepatitis

Yamada, S., Kamada, N., Amiya, T., Nakamoto, N., Nakaoka, T., Kimura, M., Saito, Y., Ejima, C., Kanai, T. & Saito, H., 2017 Nov 29, In : BMC Gastroenterology. 17, 1, 136.

Research output: Contribution to journalArticle

High Fat Diet
Fatty Liver
Fatty Acids
Inflammation
Liver
62 Citations (Scopus)

Gut microbiota promotes obesity-associated liver cancer through pge2-mediated suppression of antitumor immunity

Loo, T. M., Kamachi, F., Watanabe, Y., Yoshimoto, S., Kanda, H., Arai, Y., Nakajima-Takagi, Y., Iwama, A., Koga, T., Sugimoto, Y., Ozawa, T., Nakamura, M., Kumagai, M., Watashi, K., Taketo, M. M., Aoki, T., Narumiya, S., Oshima, M., Arita, M., Hara, E. & 1 others, Ohtani, N., 2017 May 1, In : Cancer Discovery. 7, 5, p. 522-538 17 p.

Research output: Contribution to journalArticle

Liver Neoplasms
Hepatocellular Carcinoma
Immunity
Obesity
Dinoprostone
12 Citations (Scopus)

HEG1 is a novel mucin-like membrane protein that serves as a diagnostic and therapeutic target for malignant mesothelioma

Tsuji, S., Washimi, K., Kageyama, T., Yamashita, M., Yoshihara, M., Matsuura, R., Yokose, T., Kameda, Y., Hayashi, H., Morohoshi, T., Tsuura, Y., Yusa, T., Sato, T., Togayachi, A., Narimatsu, H., Nagasaki, T., Nakamoto, K., Moriwaki, Y., Misawa, H., Hiroshima, K. & 2 others, Miyagi, Y. & Imai, K., 2017 Mar 31, In : Scientific Reports. 7, 45768.

Research output: Contribution to journalArticle

Mucins
Membrane Proteins
Therapeutics
Mesothelioma
Gene Silencing
2 Citations (Scopus)

Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation

Yotsumoto, S., Muroi, Y., Chiba, T., Ohmura, R., Yoneyama, M., Magarisawa, M., Dodo, K., Terayama, N., Sodeoka, M., Aoyagi, R., Arita, M., Arakawa, S., Shimizu, S. & Tanaka, M., 2017 Dec 1, In : Scientific Reports. 7, 1, 16026.

Research output: Contribution to journalArticle

Phospholipid Ethers
Sulfasalazine
Sulfapyridine
Lipids
Sulfones
21 Citations (Scopus)

IL-22BP dictates characteristics of Peyer's patch follicleassociated epithelium for antigen uptake

Jinnohara, T., Kanaya, T., Hase, K., Sakakibara, S., Kato, T., Tachibana, N., Sasaki, T., Hashimoto, Y., Sato, T., Watarai, H., Kunisawa, J., Shibata, N., Williams, I. R., Kiyono, H. & Ohno, H., 2017 Jun 1, In : Journal of Experimental Medicine. 214, 6, p. 1607-1618 12 p.

Research output: Contribution to journalArticle

Peyer's Patches
Carrier Proteins
Epithelium
Antigens
interleukin-22
11 Citations (Scopus)

Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis

Tokuda, E., Anzai, I., Nomura, T., Toichi, K., Watanabe, M., Ohara, S., Watanabe, S., Yamanaka, K., Morisaki, Y., Misawa, H. & Furukawa, Y., 2017 Jan 5, In : Molecular Neurodegeneration. 12, 1, 2.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Disulfides
Antibodies
Motor Neurons
Transgenic Mice
2 Citations (Scopus)

Impact of generic entry to off-patent branded medicines in Japanese pharmaceutical market

Fukumoto, D. & Suzuki, T., 2017 Sep 1, In : Journal of Generic Medicines. 13, 3, p. 114-122 9 p.

Research output: Contribution to journalArticle

Nonprescription Drugs
Pharmaceutical Preparations
Off-Label Use
Police
Health Expenditures

Improvement of dissolution rate and stability in a pirenoxine ophthalmic suspension by the bead mill methods

Ueno, A., Yamaoka, S., Ito, Y., Kotake, T., Nakazawa, Y. & Nagai, N., 2017, In : Yakugaku Zasshi. 137, 5, p. 635-641 7 p.

Research output: Contribution to journalArticle

Suspensions
Ophthalmic Solutions
Particle Size
pirenoxine
Methylcellulose
1 Citation (Scopus)

Inactivation kinetics and residual activity of CYP3A4 after treatment with erythromycin

Ishikawa, Y., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2017 Oct 1, In : Biopharmaceutics and Drug Disposition. 38, 7, p. 420-425 6 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Erythromycin
Area Under Curve
Nifedipine
Testosterone
3 Citations (Scopus)

Intracellular localization and delivery of plasmid DNA by biodegradable microsphere-mediated femtosecond laser optoporation

Ishii, A., Hiruta, Y., Heinemann, D., Heisterkamp, A., Kanazawa, H. & Terakawa, M., 2017, (Accepted/In press) In : Journal of Biophotonics.

Research output: Contribution to journalArticle

plasmids
Liposomes
Ultrashort pulses
Microspheres
delivery

Local pharmacy pharmacists’ responses to the prescription of drugs that influence driving

Nagata, T., Yamada, J., Oohara, H. & Kizu, J., 2017, In : Yakugaku Zasshi. 137, 3, p. 323-328 6 p.

Research output: Contribution to journalReview article

Prescription Drugs
Pharmacies
Pharmacists
Tokyo
Pharmaceutical Preparations
17 Citations (Scopus)

Local Release of VEGF Using Fiber Mats Enables Effective Transplantation of Layered Cardiomyocyte Sheets

Nagase, K., Nagumo, Y., Kim, M., Kim, H. J., Kyung, H. W., Chung, H. J., Sekine, H., Shimizu, T., Kanazawa, H., Okano, T., Lee, S. J. & Yamato, M., 2017, (Accepted/In press) In : Macromolecular Bioscience.

Research output: Contribution to journalArticle

Cardiac Myocytes
Vascular Endothelial Growth Factor A
Transplantation
Fibers
Cell Transplantation
13 Citations (Scopus)

Micro/nano-imprinted substrates grafted with a thermoresponsive polymer for thermally modulated cell separation

Nagase, K., Shukuwa, R., Onuma, T., Yamato, M., Takeda, N. & Okano, T., 2017, In : Journal of Materials Chemistry B. 5, 30, p. 5924-5930 7 p.

Research output: Contribution to journalArticle

Cell Separation
Polymers
Cell adhesion
Substrates
Atom transfer radical polymerization
9 Citations (Scopus)

Microbiota influences vaccine and mucosal adjuvant efficacy

Kim, Y., 2017, In : Immune Network. 17, 1, p. 20-24 5 p.

Research output: Contribution to journalReview article

Microbiota
Vaccines
Immune System
Sanitation
Malnutrition
1 Citation (Scopus)

Model for studying anti- allergic drugs for allergic conjunctivitis in animals

Nakazawa, Y., Oka, M. & Takehana, M., 2017 Jan 1, In : Open Medicine (Poland). 12, 1, p. 231-238 8 p.

Research output: Contribution to journalArticle

Allergic Conjunctivitis
Anti-Allergic Agents
Ovalbumin
Tears
Eosinophils
7 Citations (Scopus)

mTOR signaling mediates resistance to tankyrase inhibitors in Wnt-driven colorectal cancer

Mashima, T., Taneda, Y., Jang, M. K., Mizutani, A., Muramatsu, Y., Yoshida, H., Sato, A., Tanaka, N., Sugimoto, Y. & Seimiya, H., 2017, In : Oncotarget. 8, 29, p. 47902-47915 14 p.

Research output: Contribution to journalArticle

Tankyrases
Catenins
Colorectal Neoplasms
Cell Line
Poly(ADP-ribose) Polymerases