Faculty of Pharmacy

Research Output 1975 2020

2017
4 Citations (Scopus)

Myelinating cocultures of rodent stem cell line-derived neurons and immortalized Schwann cells

Ishii, T., Kawakami, E., Endo, K., Misawa, H. & Watabe, K., 2017, (Accepted/In press) In : Neuropathology.

Research output: Contribution to journalArticle

Schwann Cells
Coculture Techniques
Rodentia
Stem Cells
Neurons
5 Citations (Scopus)

NALT M cells are important for immune induction for the common mucosal immune system

Date, Y., Ebisawa, M., Fukuda, S., Shima, H., Obata, Y., Takahashi, D., Kato, T., Hanazato, M., Nakato, G., Williams, I. R., Hase, K. & Ohno, H., 2017 Oct 1, In : International Immunology. 29, 10, p. 471-478 8 p.

Research output: Contribution to journalArticle

Nasopharynx
Lymphoid Tissue
Immune System
Attenuated Vaccines
Nose

National survey of therapeutic drug monitoring (TDM) of antimicrobial drugs: Comparison with the TDM guidelines for antimicrobial drugs

Matsumoto, K., Isoda, R., Kuroda, Y., Yokoyama, Y. & Kizu, J., 2017 Mar 1, In : Japanese Journal of Chemotherapy. 65, 2, p. 175-182 8 p.

Research output: Contribution to journalArticle

Drug Monitoring
Guidelines
Infection Control
Pharmaceutical Preparations
Pharmacists
55 Citations (Scopus)

Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens

Kim, Y., Sakamoto, K., Seo, S. U., Pickard, J. M., Gillilland, M. G., Pudlo, N. A., Hoostal, M., Li, X., Wang, T. D., Feehley, T., Stefka, A. T., Schmidt, T. M., Martens, E. C., Fukuda, S., Inohara, N., Nagler, C. R. & Núñez, G., 2017 Apr 21, In : Science. 356, 6335, p. 315-319 5 p.

Research output: Contribution to journalArticle

Clostridium
Microbiota
Infection
Immune System
Pathology
1 Citation (Scopus)

NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome

Hayakawa, K., Formica, A. M., Zhou, Y., Ichikawa, D., Asano, M., Li, Y. S., Shinton, S. A., Brill-Dashoff, J., Núñez, G. & Hardy, R. R., 2017, In : Journal of Experimental Medicine. 214, 10, p. 3067-3083 17 p.

Research output: Contribution to journalArticle

B-Cell Antigen Receptors
B-Lymphocytes
Ligands
Immunoglobulin Light Chains
Autoantigens
3 Citations (Scopus)

Non-Planar [n]Cyclo-1,8-carbazolylenes (n=3,4,6) and [3]Cyclo-1,8-carbazolylenyl B, P, PO, SiPh Complexes

Yamamoto, K., Pandit, P. & Higashibayashi, S., 2017 Oct 9, In : Chemistry - A European Journal. 23, 56, p. 14011-14016 6 p.

Research output: Contribution to journalArticle

Oligomerization
Polysilicon
Acidity
Electronic structure
Boron

Novel mechanisms of resistance to investigational molecularly targeted drugs

Noguchi, K., 2017, In : Yakugaku Zasshi. 137, 2, p. 151-160 10 p.

Research output: Contribution to journalReview article

Drug Resistance
Pharmaceutical Preparations
Neoplasms
Molecular Targeted Therapy
Precision Medicine

On the existence of a darling-kac set for the renormalized rauzy map

Inoue, K. & Nakada, H., 2017 Jan 1, In : Tokyo Journal of Mathematics. 34, 2, p. 289-302 14 p.

Research output: Contribution to journalArticle

Ergodicity
Imply
23 Citations (Scopus)

On-treatment decrease of NKG2D correlates to early emergence of clinically evident hepatocellular carcinoma after interferon-free therapy for chronic hepatitis C

Cho, H., Nakamoto, N., Taniki, N., Ojiro, K., Amiya, T., Makita, Y., Murata, H., Yamaguchi, A., Shiba, S., Miyake, R., Katayama, T., Yoshida, A., Ikura, A., Takeda, K., Ebinuma, H., Saito, H. & Kanai, T., 2017 Jun 1, In : PLoS One. 12, 6, e0179096.

Research output: Contribution to journalArticle

chronic hepatitis C
antiviral agents
Chronic Hepatitis C
interferons
hepatoma
6 Citations (Scopus)

Ophthalmic formulation containing nilvadipine nanoparticles prevents retinal dysfunction in rats injected with streptozotocin

Deguchi, S., Otake, H., Nakazawa, Y., Hiramatsu, N., Yamamoto, N. & Nagai, N., 2017 Dec 15, In : International Journal of Molecular Sciences. 18, 12, 2720.

Research output: Contribution to journalArticle

nilvadipine
Streptozocin
Nanoparticles
rats
Rats
Generic Drugs
Japan
Cytostatic Agents
Pharmaceutical Preparations
Neoplasms
2 Citations (Scopus)

Patients taking antihistamines and their effects on driving

Kizu, J., 2017, In : Yakugaku Zasshi. 137, 3, p. 315-321 7 p.

Research output: Contribution to journalReview article

Histamine Antagonists
Pharmacy Education
Pharmacists
Automobile Driving
Non-Sedating Histamine H1 Antagonists

Pharmaceutical sciences advancing molecular cancer therapeutics ~To improve rationale and effectiveness of molecularly targeted drugs

Noguchi, K. & Mashima, T., 2017, In : Yakugaku Zasshi. 137, 2, p. 127-128 2 p.

Research output: Contribution to journalEditorial

Molecular Targeted Therapy
Precision Medicine
Pharmaceutical Chemistry
Drug Discovery
Pharmaceutical Preparations

Pharmaceutical sciences in the future: The bridge linking between basic and clinical research

Mochizuki, M. & Hashida, M., 2017, In : Yakugaku Zasshi. 137, 6, p. 671-672 2 p.

Research output: Contribution to journalEditorial

Research
Pharmaceutical Preparations

Pharmacists’ roles regarding the prescription of drugs that influence driving

Kizu, J. & Momose, Y., 2017, In : Yakugaku Zasshi. 137, 3, p. 307-308 2 p.

Research output: Contribution to journalEditorial

Prescription Drugs
Pharmacists
4 Citations (Scopus)

Phosphorylated CIS suppresses the Epo or JAK2 V617F mutant-triggered cell proliferation through binding to EpoR

Tago, M., Moriwaki, T., Ueda, F., Tamura, H., Kasahara, T. & Tago, K., 2017 Feb 1, In : Cellular Signalling. 31, p. 41-57 17 p.

Research output: Contribution to journalArticle

STAT5 Transcription Factor
Cell Proliferation
Neoplasms
Suppressor of Cytokine Signaling Proteins
Cytokines
43 Citations (Scopus)

Physiological functions of the cholinergic system in immune cells

Fujii, T., Mashimo, M., Moriwaki, Y., Misawa, H., Ono, S., Horiguchi, K. & Kawashima, K., 2017 May 1, In : Journal of Pharmacological Sciences. 134, 1, p. 1-21 21 p.

Research output: Contribution to journalReview article

Cholinergic Agents
Immune System
Choline O-Acetyltransferase
Dendritic Cells
T-Lymphocytes
Lipase
Alcohols
Acetylation
Enantiomers
Acetates
7 Citations (Scopus)

Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy

Ikutani, M., Tsuneyama, K., Kawaguchi, M., Fukuoka, J., Kudo, F., Nakae, S., Arita, M., Nagai, Y., Takaki, S. & Takatsu, K., 2017 Apr 6, In : JCI insight. 2, 7, p. e90721

Research output: Contribution to journalArticle

Open Access
Interleukin-5
Eosinophils
Hypertrophy
Lung
Pulmonary Artery
1 Citation (Scopus)

Propofol-fentanyl interaction in Beagles - Apnea, response to mechanical ventilation, endotracheal tube, and tetanic stimulation

Iizuka, T., Masui, K., Miyabe-Nishiwaki, T., Kanazawa, H. & Nishimura, R., 2017 Dec 1, In : Research in Veterinary Science. 115, p. 34-42 9 p.

Research output: Contribution to journalArticle

apnea
fentanyl
Fentanyl
Propofol
Apnea
12 Citations (Scopus)

Reversible conformational changes in the parallel type G-quadruplex structure inside a thermoresponsive hydrogel

Hasuike, E., Akimoto, A. M., Kuroda, R., Matsukawa, K., Hiruta, Y., Kanazawa, H. & Yoshida, R., 2017, In : Chemical Communications. 53, 21, p. 3142-3144 3 p.

Research output: Contribution to journalArticle

Hydrogels
Hydrogel
Spectrophotometers
Gels
Temperature
3 Citations (Scopus)

Risk factors for abnormal hepatic enzyme elevation by methotrexate treatment in patients with rheumatoid arthritis: A hospital based-cohort study

Hakamata, J., Hashiguchi, M., Kaneko, Y., Yamaoka, K., Shimizu, M., Maruyama, J., Takeuchi, T. & Mochizuki, M., 2017 Dec 27, (Accepted/In press) In : Modern Rheumatology. p. 1-10 10 p.

Research output: Contribution to journalArticle

Methotrexate
Rheumatoid Arthritis
Cohort Studies
Liver
Enzymes
5 Citations (Scopus)

Roasting Enhances the Anti-Cataract Effect of Coffee Beans: Ameliorating Selenite-Induced Cataracts in Rats

Ishimori, N., Oguchi, J., Nakazawa, Y., Kobata, K., Tago, M. & Tamura, H., 2017 Jan 28, (Accepted/In press) In : Current Eye Research. p. 1-7 7 p.

Research output: Contribution to journalArticle

Selenious Acid
Coffee
Cataract
Caffeine
Antioxidants
2 Citations (Scopus)

Sex Differences in the Blood Concentration of Tacrolimus in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients with CYP3A5*3/*3

Ito, A., Okada, Y., Hashita, T., Aomori, T., Hiromura, K., Nojima, Y., Nakamura, T., Araki, T. & Yamamoto, K., 2017 Mar 21, (Accepted/In press) In : Biochemical Genetics. p. 1-10 10 p.

Research output: Contribution to journalArticle

tacrolimus
Cytochrome P-450 CYP3A
lupus erythematosus
rheumatoid arthritis
Tacrolimus
9 Citations (Scopus)

Short-step syntheses of naturally occurring polyoxygenated aromatics based on site-selective transformation

Yamashita, Y., Biard, A., Hanaya, K., Shoji, M. & Sugai, T., 2017, In : Bioscience, Biotechnology and Biochemistry. 81, 7, p. 1279-1284 6 p.

Research output: Contribution to journalArticle

Molecules
chrysin
polydatin
wogonin
astringin

Significant decreases in blood propofol concentrations during adrenalectomy for phaeochromocytoma

Watanabe, T., Hiraoka, H., Araki, T., Nagano, D., Aomori, T., Nakamura, T., Yamamoto, K. & Baba, H., 2017, (Accepted/In press) In : British Journal of Clinical Pharmacology.

Research output: Contribution to journalArticle

Adrenalectomy
Pheochromocytoma
Propofol
Arterial Pressure
Neoplasms
1 Citation (Scopus)

Site-Selective Lipase-Catalyzed Acylation and Deacylation in the Synthesis of Valuable Carbohydrates and Flavonoids From Naturally Abundant Starting Materials

Tsunekawa, R., Hanaya, K., Shoji, M. & Sugai, T., 2017 Aug 15, Future Directions in Biocatalysis: Second Edition. Elsevier, p. 279-295 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Acylation
Flavonoids
Nucleophiles
Catalyst selectivity
Lipases
1 Citation (Scopus)

ST2 gene products critically contribute to cellular transformation caused by an oncogenic Ras mutant

Tago, K., Ohta, S., Kashiwada, M., Tago, M., Matsugi, J., Tominaga, S. I. & Yanagisawa, K., 2017, (Accepted/In press) In : Heliyon.

Research output: Contribution to journalArticle

Gene Expression
Genes
Fibroblasts
Cell Proliferation
Gene Knockdown Techniques

Startup of pedagogy in pharmaceutical education —What to see, how to consider and what is revealed

Arita, E. & Ishikawa, S., 2017, In : Yakugaku Zasshi. 137, 4, p. 393-394 2 p.

Research output: Contribution to journalEditorial

4 Citations (Scopus)

STAT3 and ERK pathways are involved in cell growth stimulation of the ST2/IL1RL1 promoter

Tago, K., Ohta, S., Tago, M., Aoki-Ohmura, C., Matsugi, J., Tominaga, S. I. & Yanagisawa, K., 2017 Feb 1, In : FEBS Open Bio. 7, 2, p. 293-302 10 p.

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Cell growth
Genes
Growth
Gene Expression
1 Citation (Scopus)

Status and problems of humanities education with respect to pharmacy education

Ishikawa, S., 2017, In : Yakugaku Zasshi. 137, 4, p. 399-405 7 p.

Research output: Contribution to journalReview article

Pharmacy Education
Education
Pharmacists
Curriculum
Communication
1 Citation (Scopus)

Strategic drug design to avoid the metabolic activation of hepatotoxic drugs

Ohe, T., Takahashi, K., Nakamura, S. & Mashino, T., 2017, In : Yakugaku Zasshi. 137, 3, p. 249-255 7 p.

Research output: Contribution to journalReview article

Benzbromarone
Drug Design
Pharmaceutical Preparations
Drug-Related Side Effects and Adverse Reactions
Catechols
1 Citation (Scopus)

Suppression of infliximab antibody levels by azathioprine in patients with rheumatoid arthritis

Aomori, T., Tsuchiya, A., Suzuki, S., Jibiki, A., Otsuka, N., Ishioka, E., Kaneko, Y., Takeuchi, T. & Nakamura, T., 2017, In : Pharmazie. 72, 2, p. 95-97 3 p.

Research output: Contribution to journalArticle

Azathioprine
Rheumatoid Arthritis
Antibodies
Methotrexate
Serum
11 Citations (Scopus)
Scutellaria
Flavonoids
Anti-Inflammatory Agents
Dinoprostone
Messenger RNA
2 Citations (Scopus)

Synthesis and biological evaluation of the natural product komaroviquinone and related compounds aiming at a potential therapeutic lead compound for high-risk multiple myeloma

Suto, Y., Sato, M., Fujimori, K., Kitabatake, S., Okayama, M., Ichikawa, D., Matsushita, M., Yamagiwa, N., Iwasaki, G., Kiuchi, F. & Hattori, Y., 2017 Oct 1, In : Bioorganic and Medicinal Chemistry Letters. 27, 19, p. 4558-4563 6 p.

Research output: Contribution to journalArticle

Lead compounds
Biological Products
Multiple Myeloma
Pharmaceutical Preparations
Proteasome Inhibitors
4 Citations (Scopus)

Synthesis of a C70 Fragment Buckybowl C28H14 from a C60 fragment sumanene

Hishikawa, S., Okabe, Y., Tsuruoka, R., Higashibayashi, S., Ohtsu, H., Kawano, M., Yakiyama, Y. & Sakurai, H., 2017, In : Chemistry Letters. 46, 10, p. 1556-1559 4 p.

Research output: Contribution to journalArticle

Physical properties
sumanene
1 Citation (Scopus)

Synthesis of benzyl tetra-O-acetyl-α-L-glucopyranoside from benzyl 2,3-dideoxy-β-D-Erythro-hex-2-enopyranoside

Okazaki, H., Ueda, Y., Hanaya, K., Shoji, M. & Sugai, T., 2017, In : Heterocycles. 95, 2, p. 862-871 10 p.

Research output: Contribution to journalArticle

Glucose
Derivatives
Stereochemistry
Epoxidation
Skeleton
7 Citations (Scopus)

Synthesis of enantiomerically enriched drug precursors and an insect pheromone via reduction of ketones using commercially available carbonyl reductase screening kit "Chiralscreen® OH"

Nagai, T., Sakurai, S., Natori, N., Hataoka, M., Kinoshita, T., Inoue, H., Hanaya, K., Shoji, M. & Sugai, T., 2017 Jan 14, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

Alcohol Oxidoreductases
Rivastigmine
Pheromones
Prodrugs
Ketones
Linezolid
Metabolites
Oxazolidinones
Thrombocytopenia
Renal Insufficiency
3 Citations (Scopus)
Diterpenes
Skeleton
Molecules
cotylenin A
cyclopentanone
4 Citations (Scopus)

Synthesis of trans,trans,cis-fused tetracyclic skeleton via radical domino cyclization

Furuta, M., Hanaya, K., Sugai, T. & Shoji, M., 2017 Apr 20, In : Tetrahedron. 73, 16, p. 2316-2322 7 p.

Research output: Contribution to journalArticle

Limonins
Cyclization
Skeleton
Bioactivity
Esters
Tokyo
Cholinergic Antagonists
Health Surveys
Hypnotics and Sedatives
Pharmaceutical Preparations
5 Citations (Scopus)

The importance of bioinformatics for connecting data-driven lipidomics and biological insights

Tsugawa, H., Ikeda, K. & Arita, M., 2017 Aug 1, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1862, 8, p. 762-765 4 p.

Research output: Contribution to journalReview article

6 Citations (Scopus)
consumer science
health claims
Functional Food
functional foods
Technology

Thermoresponsive Polymer Brushes for Thermally Modulated Cell Adhesion and Detachment

Nagase, K. & Okano, T., 2017 Dec 14, Polymer and Biopolymer Brushes: For Materials Science and Biotechnology. Wiley-Blackwell, p. 361-375 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cell adhesion
Brushes
Polymers
3 Citations (Scopus)

The use of a temperature-responsive column for the direct analysis of drugs in serum by two-dimensional heart-cutting liquid chromatography

Mikuma, T., Uchida, R., Kajiya, M., Hiruta, Y. & Kanazawa, H., 2017 Feb 1, In : Analytical and Bioanalytical Chemistry. 409, 4, p. 1059-1065 7 p.

Research output: Contribution to journalArticle

Liquid chromatography
Liquid Chromatography
Temperature
Serum
Pharmaceutical Preparations
4 Citations (Scopus)

Three tyrosine residues in the erythropoietin receptor are essential for Janus kinase 2 V617F mutant-induced tumorigenesis

Ueda, F., Tago, K., Tamura, H. & Tago, M., 2017 Feb 3, In : Journal of Biological Chemistry. 292, 5, p. 1826-1846 21 p.

Research output: Contribution to journalArticle

Janus Kinase 2
Erythropoietin Receptors
Tyrosine
Carcinogenesis
Phosphorylation
17 Citations (Scopus)

Tunable Surface Properties of Temperature-Responsive Polymer-Modified Liposomes Induce Faster Cellular Uptake

Wang, J., Ayano, E., Maitani, Y. & Kanazawa, H., 2017 Jan 31, In : ACS Omega. 2, 1, p. 316-325 10 p.

Research output: Contribution to journalArticle

Liposomes
Surface properties
Polymers
Temperature
Drug delivery
2016
3 Citations (Scopus)

A bis-malonic acid fullerene derivative significantly suppressed IL-33-induced IL-6 expression by inhibiting NF-κB activation

Tago, M., Miyagawa, Y., Ueda, F., Mashino, T., Moriwaki, Y., Tago, K., Kasahara, T. & Tamura, H., 2016 Nov 1, In : International Immunopharmacology. 40, p. 254-264 11 p.

Research output: Contribution to journalArticle

Fullerenes
Interleukin-6
Mast Cells
malonic acid
Interleukin-33

Actual status of adverse reactions to antimicrobials covered/not covered by a public relief system

Sato, S., Matsumoto, K., Kuroda, Y. & Kizu, J., 2016 Jul 1, In : Japanese Journal of Chemotherapy. 64, 4, p. 656-662 7 p.

Research output: Contribution to journalArticle

Anaphylaxis
Pharmaceutical Preparations
Immune System Diseases
Wounds and Injuries
Immune System