Faculty of Pharmacy

Research Output 1975 2020

2016
2 Citations (Scopus)
DNA Methylation
Histone Code
Histones
Antiviral Agents
Genes
2 Citations (Scopus)

Antimutagenic components in Glycyrrhiza against N-methyl-N-nitrosourea in the Ames assay

Inami, K., Mine, Y., Kojo, Y., Tanaka, S., Ishikawa, S. & Mochizuki, M., 2016 Jul 28, (Accepted/In press) In : Natural Product Research. p. 1-5 5 p.

Research output: Contribution to journalArticle

N-methyl-N-nitrosourea
Glycyrrhiza
Methylnitrosourea
Salmonella typhimurium
Salmonella Typhimurium
6 Citations (Scopus)
Scutellaria
Principal Component Analysis
Dinoprostone
Flavonoids
Principal component analysis

Application of Indirect Comparison to the Drug Development Process: Forecasting Direct Comparison Study Results

Kunitomi, T., Hashiguchi, M. & Mochizuki, M., 2016, (Accepted/In press) In : Journal of Clinical Pharmacology.

Research output: Contribution to journalArticle

Antipsychotic Agents
Pharmaceutical Preparations
9 Citations (Scopus)

Approaching over 10 000-fold sensitivity increase in chiral capillary electrophoresis: Cation-selective exhaustive injection and sweeping cyclodextrin-modified micellar electrokinetic chromatography

Mikuma, T., Iwata, Y. T., Miyaguchi, H., Kuwayama, K., Tsujikawa, K., Kanamori, T., Kanazawa, H. & Inoue, H., 2016, (Accepted/In press) In : Electrophoresis.

Research output: Contribution to journalArticle

Micellar Electrokinetic Capillary Chromatography
Capillary electrophoresis
Cyclodextrins
Capillary Electrophoresis
Chromatography
1 Citation (Scopus)

A proline-type fullerene derivative inhibits adipogenesis by preventing PPARγ activation

Tago, M., Hattori, T., Ueda, F., Tago, K., Ohe, T., Mashino, T. & Tamura, H., 2016 Mar 1, In : Biochemistry and Biophysics Reports. 5, p. 259-265 7 p.

Research output: Contribution to journalArticle

Fullerenes
Adipogenesis
Peroxisome Proliferator-Activated Receptors
Proline
Chemical activation
17 Citations (Scopus)

Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates high-fat diet-induced adipocyte hypertrophy and systemic glucose intolerance in mice

Kitada, Y., Kajita, K., Taguchi, K., Mori, I., Yamauchi, M., Ikeda, T., Kawashima, M., Asano, M., Kajita, T., Ishizuka, T., Banno, Y., Kojima, I., Chun, J., Kamata, S., Ishii, I. & Morita, H., 2016 May 1, In : Endocrinology. 157, 5, p. 1839-1851 13 p.

Research output: Contribution to journalArticle

Lysosphingolipid Receptors
Glucose Intolerance
High Fat Diet
Adipocytes
Hypertrophy
1 Citation (Scopus)

Chemical reactions of 8-quinolinol derivatives and their applications to biochemical tools and enzyme inhibitors

Aoki, S., Ariyasu, S., Hanaya, K., Hisamatsu, Y. & Sugai, T., 2016, In : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 74, 5, p. 482-493 12 p.

Research output: Contribution to journalReview article

Oxyquinoline
Enzyme Inhibitors
Chemical reactions
Derivatives
Materials science
2 Citations (Scopus)

Coffee induces vascular endothelial growth factor (VEGF) expression in human neuroblastama SH-SY5Y cells

Kakio, S., Tago, M., Kobata, K. & Tamura, H., 2016 Jan 21, (Accepted/In press) In : Nutritional Neuroscience. p. 1-7 7 p.

Research output: Contribution to journalArticle

Coffee
Vascular Endothelial Growth Factor A
Neuroprotective Agents
Neuroblastoma
Neuroglia
6 Citations (Scopus)
France
Germany
Japan
Pharmaceutical Preparations
Central Nervous System Agents
5 Citations (Scopus)

Contribution of equilibrative nucleoside transporter (ENT) 2 to fluorouracil transport in rat placental trophoblast cells

Takagi, A., Nishimura, T., Akashi, T., Tomi, M. & Nakashima, E., 2016 Jun 20, (Accepted/In press) In : Drug Metabolism and Pharmacokinetics.

Research output: Contribution to journalArticle

Equilibrative-Nucleoside Transporter 2
Trophoblasts
Fluorouracil
Oocytes
Complementary RNA
5 Citations (Scopus)

Data supporting mitochondrial morphological changes by SPG13-associated HSPD1 mutants

Miyamoto, Y., Tago, M., Hasegawa, N., Eguchi, T., Tanoue, A., Tamura, H. & Yamauchi, J., 2016 Mar 1, In : Data in Brief. 6, p. 482-488 7 p.

Research output: Contribution to journalArticle

paraplegia
physical disability

DDX5 is a novel targeting protein of tumor suppressor ARF

Tago, K. & Tago, M., 2016 Apr 1, In : Seikagaku. The Journal of Japanese Biochemical Society. 88, 2, p. 207-210 4 p.

Research output: Contribution to journalReview article

DEAD-box RNA Helicases
Cyclin-Dependent Kinase Inhibitor p16
Tumor Suppressor Proteins
Tumor Suppressor Protein p53
Signal transduction
4 Citations (Scopus)

Design of tetra-arm PEG-crosslinked thermoresponsive hydrogel for 3D cell culture

Akimoto, A. M., Hasuike, E., Tada, H., Nagase, K., Okano, T., Kanazawa, H. & Yoshida, R., 2016, In : Analytical Sciences. 32, 11, p. 1203-1206 4 p.

Research output: Contribution to journalArticle

Hydrogel
Cell culture
Polyethylene glycols
Gels
Gelation
5 Citations (Scopus)

Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS

Yamanaka, T., Tosaki, A., Miyazaki, H., Kurosawa, M., Koike, M., Uchiyama, Y., Maity, S. N., Misawa, H., Takahashi, R., Shimogori, T., Hattori, N. & Nukina, N., 2016 Sep 30, In : Scientific Reports. 6, 34575.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Transcription Factors
Down-Regulation
Central Nervous System
Maintenance
12 Citations (Scopus)

Distinct Roles for the N-and C-terminal Regions of M-Sec in Plasma Membrane Deformation during Tunneling Nanotube Formation

Kimura, S., Yamashita, M., Yamakami-Kimura, M., Sato, Y., Yamagata, A., Kobashigawa, Y., Inagaki, F., Amada, T., Hase, K., Iwanaga, T., Ohno, H. & Fukai, S., 2016 Sep 15, In : Scientific Reports. 6, 33548.

Research output: Contribution to journalArticle

nanotubes
membranes
tethering
trinitrotoluene
helices
1 Citation (Scopus)

Disulfide mapping the voltage-sensing mechanism of a voltage-dependent potassium channel

Nozaki, T., Ozawa, S. I., Harada, H., Kimura, T., Osawa, M. & Shimada, I., 2016 Nov 17, In : Scientific Reports. 6, 37303.

Research output: Contribution to journalArticle

Potassium Channels
Disulfides
Membrane Potentials
Allosteric Regulation
Voltage-Gated Potassium Channels
9 Citations (Scopus)

EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity

Li, Y., Takahashi, Y., Fujii, S. I., Zhou, Y., Hong, R., Suzuki, A., Tsubata, T., Hase, K. & Wang, J. Y., 2016 Mar 3, In : Nature Communications. 7, 10836.

Research output: Contribution to journalArticle

Germinal Center
apoptosis
Autoimmunity
B-Lymphocytes
Cells
5 Citations (Scopus)

Effect of AKT3 expression on MYC- and caspase-8-dependent apoptosis caused by polo-like kinase inhibitors in HCT 116 cells

Nonomiya, Y., Noguchi, K., Tanaka, N., Kasagaki, T., Katayama, K. & Sugimoto, Y., 2016 Dec 1, In : Cancer Science. 107, 12, p. 1877-1887 11 p.

Research output: Contribution to journalArticle

HCT116 Cells
Caspase 8
P-Glycoprotein
Phosphotransferases
Apoptosis
8 Citations (Scopus)

Effect of hesperetin on chaperone activity in selenite-induced cataract

Nakazawa, Y., Oka, M., Tamura, H. & Takehana, M., 2016 Jan 1, In : Open Medicine. 11, 1, p. 183-189 7 p.

Research output: Contribution to journalArticle

Selenious Acid
Cataract
Lenses
Crystallins
Water
6 Citations (Scopus)

Eosinophil polyunsaturated fatty acid metabolism and its potential control of inflammation and allergy

Arita, M., 2016 May 20, (Accepted/In press) In : Allergology International.

Research output: Contribution to journalArticle

Unsaturated Fatty Acids
Eosinophils
Hypersensitivity
Inflammation
Tandem Mass Spectrometry
6 Citations (Scopus)

Epithelium-intrinsic MicroRNAs contribute to mucosal immune homeostasis by promoting M-cell maturation

Nakato, G., Hase, K., Sato, T., Kimura, S., Sakakibara, S., Sugiyama, M., Obata, Y., Hanazato, M., Iwanaga, T. & Ohno, H., 2016 Mar 1, In : PLoS One. 11, 3, e0150379.

Research output: Contribution to journalArticle

MicroRNAs
microRNA
homeostasis
Homeostasis
epithelium

Erratum to: LC-MS-based quantification method for Achyranthes root saponins

Kawahara, Y., Hoshino, T., Morimoto, H., Shimizu, T., Narukawa, Y., Fuchino, H., Kawahara, N. & Kiuchi, F., 2016 Apr 1, In : Journal of Natural Medicines. 70, 2, p. 300 1 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Evaluating the Effectiveness of Repricing for Market Expansion in the Japanese Drug Pricing System

Shibata, S., Uemura, R. & Suzuki, T., 2016 Nov 1, In : Therapeutic Innovation and Regulatory Science. 50, 6, p. 751-758 8 p.

Research output: Contribution to journalArticle

Costs and Cost Analysis
Pharmaceutical Preparations
Japan
National Health Programs
Reward

Evaluation of the total antioxidant effect of complex-type supplements

Itoh, Y., Hiraide, S., Hoshino, Y., Shigeta, M. & Kanazawa, H., 2016, In : Bunseki Kagaku. 65, 9, p. 519-526 8 p.

Research output: Contribution to journalComment/debate

Antioxidants
Liquid chromatography
Chemical analysis
Nutrients
Health
2 Citations (Scopus)

Ex Situ Enantioconvergent Approaches for the Effective Use of Undesired­ Isomers: Stereochemical Convergence of a Substrate with Multiple Chiral Centers and Recycling of a Decarboxylated Byproduct

Yamashita, Y., Kurihara, T., Horiguchi, T., Miki, A., Shoji, M., Sugai, T. & Hanaya, K., 2016 Mar 16, (Accepted/In press) In : Synthesis (Germany).

Research output: Contribution to journalArticle

Isomers
Byproducts
Recycling
Substrates
Enzyme kinetics
8 Citations (Scopus)
Drug Discovery
Reward
Japan
Pharmaceutical Preparations
Orphan Drug Production
4 Citations (Scopus)

Fine-tuning of the mucosal barrier and metabolic systems using the diet-microbial metabolite axis

Nagai, M., Obata, Y., Takahashi, D. & Hase, K., 2016 Mar 10, (Accepted/In press) In : International Immunopharmacology.

Research output: Contribution to journalArticle

Immune System
Diet
Microbiota
Metabolic Diseases
Feeding Behavior
1 Citation (Scopus)
Streptomycin
Japan
History
Anti-Bacterial Agents
Technology
Japan
History
Anti-Bacterial Agents
Streptomycin
Penicillins
2 Citations (Scopus)
Penicillins
Quality Control
Japan
History
Anti-Bacterial Agents
5 Citations (Scopus)

Identification of approved drugs that inhibit the binding of amyloid β oligomers to ephrin type-B receptor 2

Suzuki, K., Aimi, T., Ishihara, T. & Mizushima, T., 2016, (Accepted/In press) In : FEBS Open Bio.

Research output: Contribution to journalArticle

Eph Family Receptors
Oligomers
Amyloid
Alzheimer Disease
Pharmaceutical Preparations
3 Citations (Scopus)

Identification of novel HLA-A∗24: 02-restricted epitope derived from a homeobox protein expressed in hematological malignancies

Matsushita, M., Otsuka, Y., Tsutsumida, N., Tanaka, C., Uchiumi, A., Ozawa, K., Suzuki, T., Ichikawa, D., Aburatani, H., Okamoto, S., Kawakami, Y. & Hattori, Y., 2016 Jan 1, In : PLoS One. 11, 1, e0146371.

Research output: Contribution to journalArticle

HLA-A24 Antigen
decitabine
homeodomain proteins
Homeodomain Proteins
T-cells
11 Citations (Scopus)

Immobilization of the Gas Signaling Molecule H2S by Radioisotopes: Detection, Quantification, and In Vivo Imaging

Sarkar, S., Ha, Y. S., Soni, N., An, G. I., Lee, W., Kim, M. H., Huynh, P. T., Ahn, H., Bhatt, N., Lee, Y. J., Kim, J. Y., Park, K. M., Ishii, I., Kang, S. G. & Yoo, J., 2016, (Accepted/In press) In : Angewandte Chemie - International Edition.

Research output: Contribution to journalArticle

Radioisotopes
Gases
Imaging techniques
Molecules
Positron emission tomography
8 Citations (Scopus)
Drug Discovery
Reward
Pharmaceutical Preparations
Japan
Neurosciences
61 Citations (Scopus)

Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation

Wedmann, R., Onderka, C., Wei, S., Szijártó, I. A., Miljkovic, J. L., Mitrovic, A., Lange, M., Savitsky, S., Yadav, P. K., Torregrossa, R., Harrer, E. G., Harrer, T., Ishii, I., Gollasch, M., Wood, M. E., Galardon, E., Xian, M., Whiteman, M., Banerjee, R. & Filipovic, M. R., 2016, In : Chemical Science. 7, 5, p. 3414-3426 13 p.

Research output: Contribution to journalArticle

Thioredoxins
Switches
Proteins
Hydrogen Sulfide
Cystine
15 Citations (Scopus)

Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response

Saito, Y., Nakaoka, T., Sakai, K., Muramatsu, T., Toshimitsu, K., Kimura, M., Kanai, T., Sato, T. & Saito, H., 2016 May 4, In : Scientific Reports. 6, 25311.

Research output: Contribution to journalArticle

Organoids
DNA Methylation
Neoplasms
DNA
Interferons
9 Citations (Scopus)

Inhibitory effects of flavonoids extracted from Nepalese propolis on the LPS signaling pathway

Tago, M., Ohsawa, K., Ishikawa, T., Nakamura, F., Ueda, F., Narukawa, Y., Kiuchi, F., Tamura, H., Tago, K. & Kasahara, T., 2016 Nov 1, In : International Immunopharmacology. 40, p. 550-560 11 p.

Research output: Contribution to journalArticle

Propolis
Flavonoids
Anti-Inflammatory Agents
Messenger RNA
Transcription Factors

In silico evaluation of warfarin–bucolome therapy

Ohtani, H., Hakoda, R., Imaoka, A. & Akiyoshi, T., 2016, In : Biopharmaceutics and Drug Disposition. p. 233-242 10 p.

Research output: Contribution to journalArticle

Computer Simulation
Warfarin
Therapeutics
Pharmacokinetics
Validation Studies
4 Citations (Scopus)

Layer II of placental syncytiotrophoblasts expresses MDR1 and BCRP at the apical membrane in rodents

Akashi, T., Nishimura, T., Takaki, Y., Takahashi, M., Shin, B. C., Tomi, M. & Nakashima, E., 2016 Oct 1, In : Reproductive Toxicology. 65, p. 375-381 7 p.

Research output: Contribution to journalArticle

Trophoblasts
P-Glycoprotein
Rodentia
Breast Neoplasms
Membranes
7 Citations (Scopus)

LC-MS-based quantification method for Achyranthes root saponins

Kawahara, Y., Hoshino, T., Morimoto, H., Shinizu, T., Narukawa, Y., Fuchino, H., Kawahara, N. & Kiuchi, F., 2016 Jan 1, In : Journal of Natural Medicines. 70, 1, p. 102-106 5 p.

Research output: Contribution to journalArticle

Achyranthes
Saponins
Liquid chromatography
Liquid Chromatography
Mass spectrometry
2 Citations (Scopus)

microRNA-mediated resistance to hypoglycemia in the HepG2 human hepatoma cell line

Ueki, S., Murakami, Y., Yamada, S., Kimura, M., Saito, Y. & Saito, H., 2016 Sep 15, In : BMC Cancer. 16, 1, 732.

Research output: Contribution to journalArticle

MicroRNAs
Hypoglycemia
Hepatocellular Carcinoma
Hypoglycemic Agents
Cell Line
1 Citation (Scopus)
ethnicity
immigrant
minority
citizen
religious minority
17 Citations (Scopus)

Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons

Lasiene, J., Komine, O., Fujimori-Tonou, N., Powers, B., Endo, F., Watanabe, S., Shijie, J., Ravits, J., Horner, P., Misawa, H. & Yamanaka, K., 2016 Feb 18, In : Acta neuropathologica communications. 4, p. 15 1 p.

Research output: Contribution to journalArticle

Neuregulin-1
Amyotrophic Lateral Sclerosis
Motor Neurons
Motor Neuron Disease
Maintenance
2 Citations (Scopus)

New 2-(2-Phenylethyl)chromone Derivatives and Inhibitors of Phosphodiesterase (PDE) 3A from Agarwood

Sugiyama, T., Narukawa, Y., Shibata, S., Masui, R. & Kiuchi, F., 2016 Jun 1, In : Natural Product Communications. 11, 6, p. 795-797 3 p.

Research output: Contribution to journalArticle

Type 3 Cyclic Nucleotide Phosphodiesterases
chemical derivatives
extracts
Chromones
inhibitory concentration 50
19 Citations (Scopus)
Chemical Phenomena
Molecular Weight
Molecular weight
Nuclear magnetic resonance
Proteins
6 Citations (Scopus)

Novel fullerene derivatives as dual inhibitors of Hepatitis C virus NS5B polymerase and NS3/4A protease

Kataoka, H., Ohe, T., Takahashi, K., Nakamura, S. & Mashino, T., 2016 Oct 1, In : Bioorganic and Medicinal Chemistry Letters. 26, 19, p. 4565-4567 3 p.

Research output: Contribution to journalArticle

Fullerenes
Viruses
Hepacivirus
Peptide Hydrolases
Derivatives
1 Citation (Scopus)

On the dual of Rauzy induction

Inoue, K. & NAKADA, HITOSHI., 2016 Feb 11, (Accepted/In press) In : Ergodic Theory and Dynamical Systems. p. 1-45 45 p.

Research output: Contribution to journalArticle

Proof by induction
Circle
Gauss Map
Interval
Natural Extension
88 Citations (Scopus)

P62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

Saito, T., Ichimura, Y., Taguchi, K., Suzuki, T., Mizushima, T., Takagi, K., Hirose, Y., Nagahashi, M., Iso, T., Fukutomi, T., Ohishi, M., Endo, K., Uemura, T., Nishito, Y., Okuda, S., Obata, M., Kouno, T., Imamura, R., Tada, Y., Obata, R. & 18 others, Yasuda, D., Takahashi, K., Fujimura, T., Pi, J., Lee, M. S., Ueno, T., Ohe, T., Mashino, T., Wakai, T., Kojima, H., Okabe, T., Nagano, T., Motohashi, H., Waguri, S., Soga, T., Yamamoto, M., Tanaka, K. & Komatsu, M., 2016 Jun 27, In : Nature Communications. 7, 12030.

Research output: Contribution to journalArticle

hepatitis
Phosphorylation
viruses
Viruses
Hepacivirus
50 Citations (Scopus)

Phase 2 study of stereotactic body radiotherapy and optional transarterial chemoembolization for solitary hepatocellular carcinoma not amenable to resection and radiofrequency ablation

Takeda, A., Sanuki, N., Tsurugai, Y., Iwabuchi, S., Matsunaga, K., Ebinuma, H., Imajo, K., Aoki, Y., Saito, H. & Kunieda, E., 2016, (Accepted/In press) In : Cancer.

Research output: Contribution to journalArticle

Radiosurgery
Hepatocellular Carcinoma
Survival Rate
Ethiodized Oil
Therapeutics