Faculty of Pharmacy

Research Output 1975 2020

2016
35 Citations (Scopus)

Potential role of the formation of tunneling nanotubes in HIV-1 spread in macrophages

Hashimoto, M., Bhuyan, F., Hiyoshi, M., Noyori, O., Nasser, H., Miyazaki, M., Saito, T., Kondoh, Y., Osada, H., Kimura, S., Hase, K., Ohno, H. & Suzu, S., 2016 Feb 15, In : Journal of Immunology. 196, 4, p. 1832-1841 10 p.

Research output: Contribution to journalArticle

Nanotubes
HIV-1
Macrophages
nef Gene Products
T-Lymphocytes
4 Citations (Scopus)

Potential Suppressive Effects of Two C60 Fullerene Derivatives on Acquired Immunity

Hirai, T., Yoshioka, Y., Udaka, A., Uemura, E., Ohe, T., Aoshima, H., Gao, J. Q., Kokubo, K., Oshima, T., Nagano, K., Higashisaka, K., Mashino, T. & Tsutsumi, Y., 2016 Dec 1, In : Nanoscale Research Letters. 11, 1, 449.

Research output: Contribution to journalArticle

T-cells
immunity
Fullerenes
fullerenes
Derivatives
2 Citations (Scopus)

Practical synthesis of the C-ring precursor of paclitaxel from 3-methoxytoluene

Fukaya, K., Yamaguchi, Y., Watanabe, A., Yamamoto, H., Sugai, T., Sugai, T., Satou, T. & Chida, N., 2016 Apr 1, In : Journal of Antibiotics. 69, 4, p. 273-279 7 p.

Research output: Contribution to journalArticle

Paclitaxel
Lewis Acids
Lipase
Formaldehyde
Metals
15 Citations (Scopus)

Pregnancy outcomes after exposure to tocilizumab: A retrospective analysis of 61 patients in Japan

Nakajima, K., Watanabe, O., Mochizuki, M., Nakasone, A., Ishizuka, N. & Murashima, A., 2016 Mar 3, (Accepted/In press) In : Modern Rheumatology. p. 1-5 5 p.

Research output: Contribution to journalArticle

Pregnancy Outcome
Japan
Pregnancy
Low Birth Weight Infant
Rheumatic Diseases
1 Citation (Scopus)

Preparation and antioxidant/pro-oxidant activities of 3-monosubstituted 5-hydroxyoxindole derivatives

Yasuda, D., Takahashi, K., Ohe, T., Nakamura, S. & Mashino, T., 2016 Nov 1, In : Cleft Palate-Craniofacial Journal. 59, 6, p. 165-173 9 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Antioxidants
Lipid Peroxidation
HL-60 Cells
Drug Discovery

preparation and characterization of fullerene derivatives and their nanowhiskers

Nakamura, S., Miyazawa, K. & Mashino, T., 2016 Apr 19, Fullerene Nanowhiskers. Pan Stanford Publishing Pte. Ltd., p. 53-62 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nanowhiskers
Fullerenes
fullerenes
Derivatives
preparation
12 Citations (Scopus)

Protein separations via thermally responsive ionic block copolymer brush layers

Nagase, K., Kobayashi, J., Kikuchi, A., Akiyama, Y., Kanazawa, H. & Okano, T., 2016, In : RSC Advances. 6, 31, p. 26254-26263 10 p.

Research output: Contribution to journalArticle

Brushes
Block copolymers
Proteins
Copolymers
Lactalbumin

Rapid and simultaneous analysis of psychotropic drugs by ultra-high-speed HPLC

Yoshikawa, M., Uchida, R., Kuroki, T., Mikuma, T., Hiruta, Y., Itoh, Y. & Kanazawa, I., 2016 May 10, In : Bunseki Kagaku. 65, 4, p. 173-179 7 p.

Research output: Contribution to journalArticle

Psychotropic Drugs
Pharmaceutical Preparations
Health care
Antidepressive Agents
Trazodone
1 Citation (Scopus)

Reappraisal of VAChT-Cre: Preference in slow motor neurons innervating type I or IIa muscle fibers

Misawa, H., Inomata, D., Kikuchi, M., Maruyama, S., Moriwaki, Y., Okuda, T., Nukina, N. & Yamanaka, T., 2016, (Accepted/In press) In : Genesis.

Research output: Contribution to journalArticle

Motor Neurons
Muscles
Fatigue
Fluorescence
Presynaptic Terminals

Recent Advances for Synthesis of Scyphostatin and Utilization of Oxabicyclo[2.2.1]Heptene Toward Ethyl Shikimate

Kuwata, K., Yamashita, Y., Hanaya, K., Sugai, T., Mizushima, T. & Shoji, M., 2016, Studies in Natural Products Chemistry, 2016. Elsevier, Vol. 47. p. 387-403 17 p. (Studies in Natural Products Chemistry; vol. 47).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cycloaddition Reaction
Biological Products
Lipase
Acrylics
Chlorides
8 Citations (Scopus)

Role of Cystathionine Gamma-Lyase in Immediate Renal Impairment and Inflammatory Response in Acute Ischemic Kidney Injury

Markó, L., Szijártó, I. A., Filipovic, M. R., Kaßmann, M., Balogh, A., Park, J. K., Przybyl, L., N'Diaye, G., Krämer, S., Anders, J., Ishii, I., Müller, D. N. & Gollasch, M., 2016 Jun 8, In : Scientific Reports. 6, 27517.

Research output: Contribution to journalArticle

Cystathionine gamma-Lyase
Acute Kidney Injury
Kidney
Reperfusion Injury
Hydrogen Sulfide
8 Citations (Scopus)

RSK1 protects P-glycoprotein/ABCB1 against ubiquitin-proteasomal degradation by downregulating the ubiquitin-conjugating enzyme E2 R1

Katayama, K., Fujiwara, C., Noguchi, K. & Sugimoto, Y., 2016 Oct 27, In : Scientific Reports. 6, 36134.

Research output: Contribution to journalArticle

Ubiquitin-Conjugating Enzymes
P-Glycoprotein
Ubiquitin
Down-Regulation
Ubiquitination
19 Citations (Scopus)

Selective expression of osteopontin in ALS-resistant motor neurons is a critical determinant of late phase neurodegeneration mediated by matrix metalloproteinase-9

Morisaki, Y., Niikura, M., Watanabe, M., Onishi, K., Tanabe, S., Moriwaki, Y., Okuda, T., Ohara, S., Murayama, S., Takao, M., Uchida, S., Yamanaka, K. & Misawa, H., 2016 Jun 6, In : Scientific Reports. 6, 27354.

Research output: Contribution to journalArticle

Osteopontin
Matrix Metalloproteinase 9
Amyotrophic Lateral Sclerosis
Motor Neurons
Fatigue
2 Citations (Scopus)

Sex Differences in mRNA Expression of Reduced Folate Carrier-1, Folypolyformyl Glutamate Synthase, and γ-Glutamyl Hydrolase in a Healthy Japanese Population

Hashiguchi, M., Tanaka, T., Shimizu, M., Tsuru, T., Chiyoda, T., Miyawaki, K., Irie, S., Takeuchi, O., Hakamata, J. & Mochizuki, M., 2016, (Accepted/In press) In : Journal of Clinical Pharmacology.

Research output: Contribution to journalArticle

Reduced Folate Carrier Protein
Glutamate Synthase
Hydrolases
Sex Characteristics
Messenger RNA
8 Citations (Scopus)
Regioselectivity
Dipterocarpaceae
Prenylation
Methylation
2-Propanol
12 Citations (Scopus)

Superoxide dismutase overexpression protects against glucocorticoid-induced depressive-like behavioral phenotypes in mice

Uchihara, Y., Tanaka, K. I., Asano, T., Tamura, F. & Mizushima, T., 2016 Jan 22, In : Biochemical and Biophysical Research Communications. 469, 4, p. 873-877 5 p.

Research output: Contribution to journalArticle

Glucocorticoids
Superoxide Dismutase
Phenotype
Transgenic Mice
Reactive Oxygen Species
1 Citation (Scopus)

Synthesis and antigenicity against human sera of a biotin-labeled oligosaccharide portion of a glycosphingolipid from the parasite Echinococcus multilocularis

Hada, N., Kitamura, A., Yamano, K., Schweizer, F. & Kiuchi, F., 2016, In : Chemical and Pharmaceutical Bulletin. 64, 7, p. 865-873 9 p.

Research output: Contribution to journalArticle

Echinococcus multilocularis
Glycosphingolipids
Biotin
Oligosaccharides
Parasites
13 Citations (Scopus)
Resveratrol
Burkholderia cepacia
Glycosides
Lipases
Polyphenols
17 Citations (Scopus)

Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity

Yasuda, D., Nakajima, M., Yuasa, A., Obata, R., Takahashi, K., Ohe, T., Ichimura, Y., Komatsu, M., Yamamoto, M., Imamura, R., Kojima, H., Okabe, T., Nagano, T. & Mashino, T., 2016 Dec 15, In : Bioorganic and Medicinal Chemistry Letters. 26, 24, p. 5956-5959 4 p.

Research output: Contribution to journalArticle

Derivatives
Proteins
Neoplasms
Ubiquitin
Gene expression
15 Citations (Scopus)

Temperature-responsive molecular recognition chromatography using phenylalanine and tryptophan derived polymer modified silica beads

Hiruta, Y., Kanazashi, R., Ayano, E., Okano, T. & Kanazawa, H., 2016 Feb 7, In : Analyst. 141, 3, p. 910-917 8 p.

Research output: Contribution to journalArticle

Molecular recognition
Chromatography
Phenylalanine
Tryptophan
Silicon Dioxide
9 Citations (Scopus)

The diet-microbiota-metabolite axis regulates the host physiology

Yamada, T., Takahashi, D. & Hase, K., 2016, In : Journal of Biochemistry. 160, 1, p. 1-10 10 p.

Research output: Contribution to journalReview article

Microbiota
Physiology
Nutrition
Metabolites
Diet
3 Citations (Scopus)

The Extracellular C-loop Domain Plays an Important Role in the Cell Adhesion Function of Aquaporin 0

Nakazawa, Y., Oka, M., Tago, M., Tamura, H. & Takehana, M., 2016 Oct 15, (Accepted/In press) In : Current Eye Research. p. 1-8 8 p.

Research output: Contribution to journalArticle

Cell Adhesion
Permeability
aquaporin 0
Water
Hypotonic Solutions

Therapeutic drug monitoring of anti-infective agents

Matsumoto, K., 2016 Jul 1, In : Japanese Journal of Clinical Chemistry. 45, 3, p. 228-232 5 p.

Research output: Contribution to journalArticle

Drug Monitoring
Anti-Infective Agents
Monitoring
Pharmaceutical Preparations
5 Citations (Scopus)

Thermoresponsive anionic block copolymer brushes with a strongly anionic bottom segment for effective interactions with biomolecules

Nagase, K., Kobayashi, J., Kikuchi, A., Akiyama, Y., Kanazawa, H. & Okano, T., 2016, In : RSC Advances. 6, 95, p. 93169-93179 11 p.

Research output: Contribution to journalArticle

Biomolecules
Brushes
Block copolymers
Acids
Silicon Dioxide
6 Citations (Scopus)

Transcutaneous drug delivery by liposomes using fractional laser technology

Fujimoto, T., Wang, J., Baba, K., Oki, Y., Hiruta, Y., Ito, M., Ito, S. & Kanazawa, H., 2016, (Accepted/In press) In : Lasers in Surgery and Medicine.

Research output: Contribution to journalArticle

Liposomes
Lasers
Technology
Fluorescein-5-isothiocyanate
Pharmaceutical Preparations
4 Citations (Scopus)

Two new lignans and melanogenesis inhibitors from Schisandra nigra

Narukawa, Y., Komatsu, C., Yamauchi, R., Shibayama, S., Hachisuka, M. & Kiuchi, F., 2016 May 3, (Accepted/In press) In : Journal of Natural Medicines. p. 1-7 7 p.

Research output: Contribution to journalArticle

Schisandra
Lignans
Experimental Melanomas
Monophenol Monooxygenase
Schisandraceae
Masks
Pharmacists
Emotions
Facial Expression
Hearing
29 Citations (Scopus)

Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress

Ohashi, W., Kimura, S., Iwanaga, T., Furusawa, Y., Irié, T., Izumi, H., Watanabe, T., Hijikata, A., Hara, T., Ohara, O., Koseki, H., Sato, T., Robine, S., Mori, H., Hattori, Y., Watarai, H., Mishima, K., Ohno, H., Hase, K. & Fukada, T., 2016 Oct 1, In : PLoS Genetics. 12, 10, e1006349.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
homeostasis
endoplasmic reticulum
transporters
stem cells
2015
11 Citations (Scopus)

Acceptance of surrogate end points in clinical trials supporting approval of drugs for cancer treatment by the Japanese regulatory agency

Maeda, H. & Kurokawa, T., 2015 Jan 1, In : Annals of Oncology. 26, 1, p. 211-216 6 p.

Research output: Contribution to journalArticle

Drug Approval
Japan
Biomarkers
Clinical Trials
Pharmaceutical Preparations
47 Citations (Scopus)

Activity of the dietary flavonoid, apigenin, against multidrug-resistant tumor cells as determined by pharmacogenomics and molecular docking

Saeed, M., Kadioglu, O., Khalid, H., Sugimoto, Y. & Efferth, T., 2015, In : Journal of Nutritional Biochemistry. 26, 1, p. 44-56 13 p.

Research output: Contribution to journalArticle

Apigenin
Pharmacogenetics
Flavonoids
Tumors
Cells
10 Citations (Scopus)

Aldioxa improves delayed gastric emptying and impaired gastric compliance, pathophysiologic mechanisms of functional dyspepsia

Asano, T., Aida, S., Suemasu, S., Tahara, K., Tanaka, K. I. & Mizushima, T., 2015 Dec 1, In : Scientific Reports. 5, 17519.

Research output: Contribution to journalArticle

Dyspepsia
Gastric Emptying
Allantoin
Compliance
Stomach
6 Citations (Scopus)

A novel phthalimide derivative, TC11, has preclinical effects on high-risk myeloma cells and osteoclasts

Matsushita, M., Ozaki, Y., Hasegawa, Y., Terada, F., Tabata, N., Shiheido, H., Yanagawa, H., Oikawa, T., Matsuo, K., Du, W., Yamada, T., Hozumi, M., Ichikawa, D. & Hattori, Y., 2015 Jan 24, In : PLoS One. 10, 1, e0116135.

Research output: Contribution to journalArticle

phthalimide
myeloma
osteoclasts
Osteoclasts
Multiple Myeloma
37 Citations (Scopus)

Anti-inflammatory activity of flavonoids in Nepalese propolis is attributed to inhibition of the IL-33 signaling pathway

Tago, M., Okamoto, K., Izumi, R., Tago, K., Yanagisawa, K., Narukawa, Y., Kiuchi, F., Kasahara, T. & Tamura, H., 2015, In : International Immunopharmacology. 25, 1, p. 189-198 10 p.

Research output: Contribution to journalArticle

Propolis
Flavonoids
Anti-Inflammatory Agents
Cytokines
Interleukin-13
9 Citations (Scopus)

Anti-inflammatory effects of linezolid on carrageenan-induced paw edema in rats

Matsumoto, K., Obara, S., Kuroda, Y. & Kizu, J., 2015 Dec 1, In : Journal of Infection and Chemotherapy. 21, 12, p. 889-891 3 p.

Research output: Contribution to journalArticle

Linezolid
Carrageenan
Edema
Anti-Inflammatory Agents
Theoretical Models
13 Citations (Scopus)

Arf tumor suppressor disrupts the oncogenic positive feedback loop including c-Myc and DDX5

Tago, K., Tago, M., Itoh, H., Furukawa, Y., Kikuchi, J., Kato, T., Suzuki, K. & Yanagisawa, K., 2015 Jan 15, In : Oncogene. 34, 3, p. 314-322 9 p.

Research output: Contribution to journalArticle

Neoplasms
Proteins
DEAD-box RNA Helicases
Tumor Suppressor Protein p14ARF
Tumor Suppressor Proteins

Basic studies on the stability of flavored oral solutions of rebamipide

Yajima, R., Imaoka, F., Wako, T., Kuroda, Y., Matsumoto, K., Kizu, J. & Katayama, S., 2015 Dec 1, In : Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 135, 12, p. 1397-1402 6 p.

Research output: Contribution to journalArticle

Stomatitis
Ananas
Diet
Yogurt
Malus
9 Citations (Scopus)

B cells generated by B-1 development can progress to chronic lymphocytic leukemia

Hayakawa, K., Formica, A. M., Colombo, M. J., Ichikawa, D., Shinton, S. A., Brill-Dashoff, J. & Hardy, R. R., 2015 Dec 1, In : Annals of the New York Academy of Sciences. 1362, 1, p. 250-255 6 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
Cells
B-Lymphocyte Subsets
Cell signaling
35 Citations (Scopus)

Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity

Matsumura, T., Sugawara, Y., Yutani, M., Amatsu, S., Yagita, H., Kohda, T., Fukuoka, S. I., Nakamura, Y., Fukuda, S., Hase, K., Ohno, H. & Fujinaga, Y., 2015 Feb 17, In : Nature Communications. 6, 6255.

Research output: Contribution to journalArticle

Type A Botulinum Toxins
Glycoproteins
Neurotoxins
Hemagglutinins
mice

Correlation of physicochemical property and the dissolution behavior of ingredients of an antihypertensive combination tablet

Itoh, Y., Anan, Y. & Kanazawa, H., 2015 Dec 9, In : Bunseki Kagaku. 64, 11, p. 835-844 10 p.

Research output: Contribution to journalArticle

Antihypertensive Agents
Tablets
Dissolution
Amlodipine
High performance liquid chromatography
17 Citations (Scopus)

Cost-effectiveness analysis of EGFR mutation testing and gefitinib as first-line therapy for non-small cell lung cancer

Narita, Y., Matsushima, Y., Shiroiwa, T., Chiba, K., Nakanishi, Y., Kurokawa, T. & Urushihara, H., 2015 Oct 1, In : Lung Cancer. 90, 1, p. 71-77 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Cost-Benefit Analysis
Quality-Adjusted Life Years
Mutation
1 Citation (Scopus)
Administrative Personnel
Internet
Japan
Pharmaceutical Preparations
Drug Industry

"Cutting-Edge Analytical Chemistry Research by Women Scientists"

Kanazawa, H., Yoshida, Y., Hokura, A. & Nishimoto, Y., 2015, In : Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 31, 9, p. 865 1 p.

Research output: Contribution to journalEditorial

Analytical Chemistry Techniques
Sex Factors
Research
17 Citations (Scopus)

Cytotoxicity of 35 medicinal plants from Sudan towards sensitive and multidrug-resistant cancer cells

Saeed, M. E. M., Abdelgadir, H., Sugimoto, Y., Khalid, H. E. & Efferth, T., 2015 Apr 1, In : Journal of Ethnopharmacology. 174, p. 644-658 15 p.

Research output: Contribution to journalArticle

Sudan
Medicinal Plants
Neoplasms
Complex Mixtures
Ambrosia
13 Citations (Scopus)

Cytotoxicity of the sesquiterpene lactones neoambrosin and damsin from Ambrosia maritima against multidrug-resistant cancer cells

Saeed, M., Jacob, S., Sandjo, L. P., Sugimoto, Y., Khalid, H. E., Opatz, T., Thines, E. & Efferth, T., 2015, In : Frontiers in Pharmacology. 6, NOV, 267.

Research output: Contribution to journalArticle

Ambrosia
Sesquiterpenes
Lactones
ATP-Binding Cassette Transporters
Immunoblotting
31 Citations (Scopus)

Design of Environmentally Responsive Fluorescent Polymer Probes for Cellular Imaging

Yamada, A., Hiruta, Y., Wang, J., Ayano, E. & Kanazawa, H., 2015 Aug 10, In : Biomacromolecules. 16, 8, p. 2356-2362 7 p.

Research output: Contribution to journalArticle

Polymers
Imaging techniques
Fluorescein
Fluorescence
Temperature
7 Citations (Scopus)

Development of a novel sulfonate ester-based prodrug strategy

Hanaya, K., Yoshioka, S., Ariyasu, S., Aoki, S., Shoji, M. & Sugai, T., 2015 Sep 24, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Prodrugs
Esters
Leucine
Bearings (structural)
Cyclization
10 Citations (Scopus)

Differential adaptive responses to 1- or 2-day fasting in various mouse tissues revealed by quantitative PCR analysis

Yamamoto, J., Kamata, S., Miura, A., Nagata, T., Kainuma, R. & Ishii, I., 2015 Apr 21, In : FEBS Open Bio. 5, p. 357-368 12 p.

Research output: Contribution to journalArticle

Fasting
Tissue
Polymerase Chain Reaction
Chemical analysis
Chemical activation
30 Citations (Scopus)

Discovery of novel SPAK inhibitors that block WNK kinase signaling to cation chloride transporters

Kikuchi, E., Mori, T., Zeniya, M., Isobe, K., Ishigami-Yuasa, M., Fujii, S., Kagechika, H., Ishihara, T., Mizushima, T., Sasaki, S., Sohara, E., Rai, T. & Uchida, S., 2015 Jul 1, In : Journal of the American Society of Nephrology. 26, 7, p. 1525-1536 12 p.

Research output: Contribution to journalArticle

Protein Kinase Inhibitors
Proline
Alanine
Cations
Chlorides
1 Citation (Scopus)

Distinct microRNA expression profiles in follicle-associated epithelium and villous epithelium

Nakato, G., Hase, K. & Ohno, H., 2015 Sep 1, In : Genomics Data. 5, p. 388-390 3 p.

Research output: Contribution to journalArticle

MicroRNAs
Epithelium
Intestinal Mucosa
Microarrays
Physiology
10 Citations (Scopus)

Drug repositioning for preeclampsia therapeutics by in vitro screening

Kakigano, A., Tomimatsu, T., Mimura, K., Kanayama, T., Fujita, S., Minato, K., Kumasawa, K., Taniguchi, Y., Kanagawa, T., Endo, M., Ishihara, T., Namba, T., Mizushima, T. & Kimura, T., 2015 Oct 22, In : Reproductive Sciences. 22, 10, p. 1272-1280 9 p.

Research output: Contribution to journalArticle

Drug Repositioning
Pre-Eclampsia
Pharmaceutical Preparations
Human Umbilical Vein Endothelial Cells
Therapeutics