Faculty of Pharmacy

Research Output 1975 2020

2015
19 Citations (Scopus)

Effect of database profile variation on drug safety assessment: An analysis of spontaneous adverse event reports of Japanese cases

Nomura, K., Takahashi, K., Hinomura, Y., Kawaguchi, G., Matsushita, Y., Marui, H., Anzai, T., Hashiguchi, M. & Mochizuki, M., 2015 Jun 12, In : Drug Design, Development and Therapy. 9, p. 3031-3041 11 p.

Research output: Contribution to journalArticle

United States Food and Drug Administration
Drug-Related Side Effects and Adverse Reactions
Databases
Safety
Pharmaceutical Preparations
7 Citations (Scopus)

Effects of terminal group and chain length on temperature-responsive chromatography utilizing poly(N-isopropylacrylamide) synthesized via RAFT polymerization

Hiruta, Y., Nagumo, Y., Miki, A., Okano, T. & Kanazawa, H., 2015 Aug 24, In : RSC Advances. 5, 89, p. 73217-73224 8 p.

Research output: Contribution to journalArticle

Chromatography
Chain length
Polymerization
Polymers
Silicon Dioxide
6 Citations (Scopus)

Elucidation of molybdosilicate complexes in the molybdate yellow method by ESI-MS

Takahashi, M., Abe, Y. & Tanaka, M., 2015, In : Talanta. 131, p. 301-308 8 p.

Research output: Contribution to journalArticle

Silicic Acid
Sulfates
Condensation
Polymers
Monomers
11 Citations (Scopus)

Encapsulation of beraprost sodium in nanoparticles: Analysis of sustained release properties, targeting abilities and pharmacological activities in animal models of pulmonary arterial hypertension

Ishihara, T., Hayashi, E., Yamamoto, S., Kobayashi, C., Tamura, Y., Sawazaki, R., Tamura, F., Tahara, K., Kasahara, T., Ishihara, T., Takenaga, M., Fukuda, K. & Mizushima, T., 2015 Jan 10, In : Journal of Controlled Release. 197, p. 97-104 8 p.

Research output: Contribution to journalArticle

beraprost
Pulmonary Hypertension
Nanoparticles
Animal Models
Pharmacology
36 Citations (Scopus)

Epigenetic modifications of the immune system in health and disease

Obata, Y., Furusawa, Y. & Hase, K., 2015 Mar 19, In : Immunology and Cell Biology. 93, 3, p. 226-232 7 p.

Research output: Contribution to journalArticle

Epigenomics
Immune System
Health
Epithelial Cells
Antigens

Establishment of a recessive mutant small-eye rat with lens involution and retinal detachment associated with partial deletion and rearrangement of the Cryba1 gene

Yamada, T., Nanashima, N., Shimizu, T., Nakazawa, Y., Nakazawa, M. & Tsuchida, S., 2015 Oct 15, In : Biochemical Journal. 471, 2, p. 293-305 13 p.

Research output: Contribution to journalArticle

Gene Rearrangement
Retinal Detachment
Lenses
Rats
Genes
1 Citation (Scopus)

Factors Affecting the Timing of Signal Detection of Adverse Drug Reactions

Hashiguchi, M., Imai, S., Uehara, K., Maruyama, J., Shimizu, M. & Mochizuki, M., 2015 Dec 1, In : PLoS One. 10, 12, e0144263.

Research output: Contribution to journalArticle

Signal detection
Drug-Related Side Effects and Adverse Reactions
drugs
Pharmaceutical Preparations
Teriparatide
9 Citations (Scopus)

First-line eradication for Helicobacter pylori -positive gastritis by esomeprazole-based triple therapy is influenced by CYP2C19 genotype

Saito, Y., Serizawa, H., Kato, Y., Nakano, M., Nakamura, M., Saito, H., Suzuki, H. & Kanai, T., 2015 Dec 28, In : World Journal of Gastroenterology. 21, 48, p. 13548-13554 7 p.

Research output: Contribution to journalArticle

Esomeprazole
Gastritis
Helicobacter pylori
Genotype
Pepsinogen A
1 Citation (Scopus)

Genotype-associated differential NKG2D expression on CD56+CD3+ lymphocytes predicts response to pegylated-interferon/ribavirin therapy in chronic hepatitis C

Cho, H., Ebinuma, H., Nakamoto, N., Sugiyama, K., Usui, S., Wakayama, Y., Taniki, N., Yamaguchi, A., Shiba, S., Yamagishi, Y., Wakita, T., Hibi, T., Saito, H. & Kanai, T., 2015 May 12, In : PLoS One. 10, 5, e0125664.

Research output: Contribution to journalArticle

chronic hepatitis C
Lymphocytes
Ribavirin
Chronic Hepatitis C
interferons
16 Citations (Scopus)

Hemizygosity of transsulfuration genes confers increased vulnerability against acetaminophen-induced hepatotoxicity in mice

Hagiya, Y., Kamata, S., Mitsuoka, S., Okada, N., Yoshida, S., Yamamoto, J., Ohkubo, R., Abiko, Y., Yamada, H., Akahoshi, N., Kasahara, T., Kumagai, Y. & Ishii, I., 2015 Jan 5, In : Toxicology and Applied Pharmacology. 282, 2, p. 195-206 12 p.

Research output: Contribution to journalArticle

Acetaminophen
Genes
Cystathionine
Glutathione
Imines
10 Citations (Scopus)

Hesperetin prevents selenite-induced cataract in rats

Nakazawa, Y., Oka, M., Bando, M. & Takehana, M., 2015 Jul 31, In : Molecular Vision. 21, p. 804-810 7 p.

Research output: Contribution to journalArticle

Selenious Acid
Cataract
Lenses
Ascorbic Acid
Sodium Selenite
10 Citations (Scopus)

Hypomyelinating leukodystrophy-associated missense mutation in HSPD1 blunts mitochondrial dynamics

Miyamoto, Y., Eguchi, T., Kawahara, K., Hasegawa, N., Nakamura, K., Tago, M., Tanoue, A., Tamura, H. & Yamauchi, J., 2015 Jun 3, In : Biochemical and Biophysical Research Communications. 462, 3, p. 275-281 7 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Missense Mutation
Myelin Sheath
Oligodendroglia
Mutation
6 Citations (Scopus)

Identification of HSP70-inducing activity in Arnica montana extract and purification and characterization of HSP70-inducers

Usui, K., Ikeda, T., Horibe, Y., Nakao, M., Hoshino, T. & Mizushima, T., 2015 Apr 1, In : Journal of Dermatological Science. 78, 1, p. 67-75 9 p.

Research output: Contribution to journalArticle

Arnica
Cosmetics
Melanins
Cytotoxicity
Purification
14 Citations (Scopus)

IL-22/STAT3-induced increases in SLURP1 expression within psoriatic lesions exerts antimicrobial effects against Staphylococcus aureus

Moriwaki, Y., Takada, K., Nagasaki, T., Kubo, N., Ishii, T., Kose, K., Kageyama, T., Tsuji, S., Kawashima, K. & Misawa, H., 2015 Oct 16, In : PLoS One. 10, 10, 140750.

Research output: Contribution to journalArticle

psoriasis
keratinocytes
anti-infective properties
Keratinocytes
Psoriasis
4 Citations (Scopus)

Induction of heme-oxygenase-1 (HO-1) does not enhance adiponectin production in human adipocytes: Evidence against a direct HO-1 - Adiponectin axis

Yang, M., Kimura, M., Ng, C., He, J., Keshvari, S., Rose, F. J., Barclay, J. L. & Whitehead, J. P., 2015 Sep 5, In : Molecular and Cellular Endocrinology. 413, p. 209-216 8 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Adiponectin
Adipocytes
Hemin
Adipokines
5 Citations (Scopus)

Measurement of the dynamic behavior of thin poly(N-isopropylacrylamide) hydrogels and their phase transition temperatures measured using reflectometric interference spectroscopy

Okada, F., Akiyama, Y., Kobayashi, J., Ninomiya, H., Kanazawa, H., Yamato, M. & Okano, T., 2015, In : Journal of Nanoparticle Research. 17, 3

Research output: Contribution to journalArticle

Hydrogel
Hydrogels
Dynamic Behavior
Superconducting transition temperature
Spectroscopy
57 Citations (Scopus)

Medications associated with falls in older people: Systematic review of publications from a recent 5-year period

Park, H., Satoh, H., Miki, A., Urushihara, H. & Sawada, Y., 2015 Dec 1, In : European Journal of Clinical Pharmacology. 71, 12, p. 1429-1440 12 p.

Research output: Contribution to journalArticle

Publications
Polypharmacy
Hypnotics and Sedatives
Antihypertensive Agents
Antidepressive Agents
53 Citations (Scopus)

Meta-Analysis: Effects of probiotic supplementation on lipid profiles in normal to mildly hypercholesterolemic individuals

Shimizu, M., Hashiguchi, M., Shiga, T., Tamura, H. & Mochizuki, M., 2015 Oct 16, In : PLoS One. 10, 10, e0139795.

Research output: Contribution to journalArticle

Probiotics
meta-analysis
probiotics
Meta-Analysis
Lipids
10 Citations (Scopus)

Methods for estimating causal relationships of adverse events with dietary supplements

Ide, K., Yamada, H., Kitagawa, M., Kawasaki, Y., Buno, Y., Matsushita, K., Kaji, M., Fujimoto, K., Waki, M., Nakashima, M. & Umegaki, K., 2015, In : BMJ Open. 5, 11, e009038.

Research output: Contribution to journalArticle

Dietary Supplements
United States Food and Drug Administration
Nutritionists
Pharmacists
Research Personnel
3 Citations (Scopus)
Pharmaceutical Preparations
Clinical Trials
Japan
Health
Tolnaftate
1 Citation (Scopus)

Nano-scale physical surface coating of temperature-responsive polymers for cell sheet fabrication

Nakayama, M., Kimura, Y., Kanazawa, H., Yamato, M. & Okano, T., 2015 Jan 9, 2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014. Institute of Electrical and Electronics Engineers Inc., 7006167

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fabrication
Coatings
Polymers
Chain length
Temperature
16 Citations (Scopus)

Natural anti-intestinal goblet cell autoantibody production from marginal zone B cells

Ichikawa, D., Asano, M., Shinton, S. A., Brill-Dashoff, J., Formica, A. M., Velcich, A., Hardy, R. R. & Hayakawa, K., 2015 Jan 15, In : Journal of Immunology. 194, 2, p. 606-614 9 p.

Research output: Contribution to journalArticle

Goblet Cells
Autoantibodies
B-Lymphocytes
B-Lymphocyte Subsets
Immunoglobulin M
7 Citations (Scopus)
Lamiaceae
Transcriptional Activation
Anti-Inflammatory Agents
Lions
Messenger RNA
4 Citations (Scopus)
Phenol
Lipase
Alkenylation
Propolis
2-Propanol
8 Citations (Scopus)

No Contribution of the ABCB11 p.444A Polymorphism in Japanese Patients with Drug-Induced Cholestasis

Kagawa, T., Hirose, S., Arase, Y., Oka, A., Anzai, K., Tsuruya, K., Shiraishi, K., Orii, R., Ieda, S., Nakazawa, T., Tomita, K., Hokari, R., Miura, S., Ebinuma, H., Saito, H., Kitamura, T., Horie, Y., Okuse, C., Wasada, M., Inoko, H. & 5 others, Tohkin, M., Saito, Y., Maekawa, K., Takikawa, H. & Mine, T., 2015 May 1, In : Drug Metabolism and Disposition. 43, 5, p. 691-697 7 p.

Research output: Contribution to journalArticle

Cholestasis
Gene Frequency
Pharmaceutical Preparations
Taurocholic Acid
Liver
36 Citations (Scopus)

Non-neuronal cholinergic system in regulation of immune function with a focus on α7 nAChRs

Kawashima, K., Fujii, T., Moriwaki, Y., Misawa, H. & Horiguchi, K., 2015 Feb 8, In : International Immunopharmacology. 29, 1, p. 127-134 8 p.

Research output: Contribution to journalArticle

Acetylcholine
T-Lymphocytes
Choline O-Acetyltransferase
Dendritic Cells
B-Lymphocytes
10 Citations (Scopus)

Novel bioactivation pathway of benzbromarone mediated by cytochrome P450

Kitagawara, Y., Ohe, T., Tachibana, K., Takahashi, K., Nakamura, S. & Mashino, T., 2015 Sep 1, In : Drug Metabolism and Disposition. 43, 9, p. 1303-1306 4 p.

Research output: Contribution to journalArticle

Benzbromarone
Cytochrome P-450 Enzyme System
Cytochrome P-450 CYP1A1
Liver
Pharmaceutical Preparations
2 Citations (Scopus)

Novel monoterpene lactones from Cinnamomum inunctum

Fuchino, H., Yazawa, A., Kiuchi, F., Kawahara, N., Takahashi, Y. & Satake, M., 2015 Oct 1, In : Chemical and Pharmaceutical Bulletin. 63, 10, p. 833-836 4 p.

Research output: Contribution to journalArticle

Cinnamomum
4-Butyrolactone
Myanmar
Monoterpenes
Spironolactone

Nutritional status and body composition dynamics with peginterferon alpha and ribavirin combination therapy in chronic hepatitis C patients

Takahashi, M., Kikuchi, M., Ebinuma, H. & Saito, H., 2015, In : International Journal of Virology. 11, 1, p. 12-19 8 p.

Research output: Contribution to journalArticle

Ribavirin
Chronic Hepatitis C
Body Composition
Nutritional Status
Adipose Tissue
9 Citations (Scopus)

Organic Anion Transporter 4-Mediated Transport of Olmesartan at Basal Plasma Membrane of Human Placental Barrier

Noguchi, S., Nishimura, T., Fujibayashi, A., Maruyama, T., Tomi, M. & Nakashima, E., 2015 Sep 1, In : Journal of Pharmaceutical Sciences. 104, 9, p. 3128-3135 8 p.

Research output: Contribution to journalArticle

Organic Anion Transporters
Cell Membrane
Trophoblasts
Dehydroepiandrosterone Sulfate
Chlorides
2 Citations (Scopus)

Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation

Fujimori, K., Takaki, J., Shigemoto-Mogami, Y., Sekino, Y., Suzuki, T. & Sato, K., 2015, In : Journal of Pharmacological Sciences. 127, 1, p. 145-149 5 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Paroxetine
Glutamic Acid
Down-Regulation
Astrocytes
13 Citations (Scopus)

Patients views and experiences in online reporting adverse drug reactions: Findings of a national pilot study in Japan

Yamamoto, M., Kubota, K., Okazaki, M., Dobashi, A., Hashiguchi, M., Doi, H., Suka, M. & Mochizuki, M., 2015 Jan 23, In : Patient Preference and Adherence. 9, p. 173-184 12 p.

Research output: Contribution to journalArticle

Drug-Related Side Effects and Adverse Reactions
Japan
reporter
drug
experience
22 Citations (Scopus)

PH/temperature-responsive fluorescence polymer probe with pH-controlled cellular uptake

Hiruta, Y., Funatsu, T., Matsuura, M., Wang, J., Ayano, E. & Kanazawa, H., 2015, In : Sensors and Actuators, B: Chemical. PartA, p. 724-731 8 p.

Research output: Contribution to journalArticle

Polymers
Fluorescence
fluorescence
probes
polymers
3 Citations (Scopus)

Pharmacokinetics and brain penetration of carbapenems in mice

Matsumoto, K., Kurihara, Y., Kuroda, Y., Hori, S. & Kizu, J., 2015 Jul 13, (Accepted/In press) In : Journal of Infection and Chemotherapy.

Research output: Contribution to journalArticle

Carbapenems
Pharmacokinetics
meropenem
doripenem
biapenem
4 Citations (Scopus)

Pharmacokinetics and dosing estimation of meropenem in Japanese patients receiving continuous venovenous hemodialysis

Kawano, S., Matsumoto, K., Hara, R., Kuroda, Y., Ikawa, K., Morikawa, N., Horino, T., Hori, S. & Kizu, J., 2015 Jun 1, In : Journal of Infection and Chemotherapy. 21, 6, p. 476-478 3 p.

Research output: Contribution to journalArticle

meropenem
Renal Dialysis
Pharmacokinetics
Japan
Critical Illness
2 Citations (Scopus)

Pharmacokinetics and skin-tissue penetration of daptomycin in rats

Matsumoto, K., Kitaoka, M., Kuroda, Y., Ikawa, K., Morikawa, N., Sasaki, J., Iketani, O., Iwata, S., Horino, T., Hori, S. & Kizu, J., 2015 May 21, In : Clinical Pharmacology: Advances and Applications. 7, p. 79-82 4 p.

Research output: Contribution to journalArticle

Daptomycin
Pharmacokinetics
Skin
Infection
Protein Binding
3 Citations (Scopus)

Pregnant woman with non-comatose autoimmune acute liver failure in the second trimester rescued using medical therapy: A case report

Sato, H., Tomita, K., Yasue, C., Umeda, R., Ebinuma, H., Ogata, S., Du, W., Soga, S., Maruta, K., Yasutake, Y., Narimatsu, K., Usui, S., Watanabe, C., Komoto, S., Teratani, T., Suzuki, T., Yokoyama, H., Saito, H., Nagao, S., Hibi, T. & 3 others, Miura, S., Kanai, T. & Hokari, R., 2015 Mar 1, In : Hepatology Research. 45, 3, p. 349-355 7 p.

Research output: Contribution to journalArticle

Acute Liver Failure
Second Pregnancy Trimester
Pregnant Women
Prednisolone
Liver
11 Citations (Scopus)

Protective effect of hypotaurine against oxidative stress-induced cytotoxicity in rat placental trophoblasts

Nishimura, T., Duereh, M., Sugita, Y., Yoshida, Y., Higuchi, K., Tomi, M. & Nakashima, E., 2015 Jun 1, In : Placenta. 36, 6, p. 693-698 6 p.

Research output: Contribution to journalArticle

Trophoblasts
Oxidative Stress
Extracellular Fluid
Antioxidants
hypotaurine
Liquid chromatography
Tandem Mass Spectrometry
Liquid Chromatography
Mass spectrometry
Plasmas
13 Citations (Scopus)

Recent trends for drug lag in clinical development of oncology drugs in Japan: does the oncology drug lag still exist in Japan?

Maeda, H. & Kurokawa, T., 2015 Dec 1, In : International Journal of Clinical Oncology. 20, 6, p. 1072-1080 9 p.

Research output: Contribution to journalArticle

Medical Oncology
Japan
Pharmaceutical Preparations
Clinical Trials
Drug Approval
13 Citations (Scopus)
Drug Approval
Japan
Pharmaceutical Preparations
Regression Analysis

Reply to the letter to the editor 'Surrogate end points for overall survival. Festina lente (more haste, less speed)' by Braillon

Maeda, H. & Kurokawa, T., 2015 Apr 1, In : Annals of Oncology. 26, 4, p. 818-819 2 p.

Research output: Contribution to journalArticle

Drug Approval
Drug Evaluation
Antineoplastic Agents
Biomarkers
Neoplasms
11 Citations (Scopus)

Role of OAT4 in uptake of estriol precursor 16α-hydroxydehydroepiandrosterone sulfate into human placental syncytiotrophoblasts from fetus

Tomi, M., Eguchi, H., Ozaki, M., Tawara, T., Nishimura, S., Higuchi, K., Maruyama, T., Nishimura, T. & Nakashima, E., 2015 Jul 1, In : Endocrinology. 156, 7, p. 2704-2712 9 p.

Research output: Contribution to journalArticle

Estriol
Trophoblasts
Fetus
Cell Membrane
Sulfobromophthalein

Scavenging of superoxide anions by lecithinized superoxide dismutase in HL-60 cells

Ishihara, T., Shibui, M., Hoshi, T. & Mizushima, T., 2015 Nov 13, In : Molecular BioSystems. 12, 1, p. 274-282 9 p.

Research output: Contribution to journalArticle

HL-60 Cells
Superoxides
Therapeutic Uses
Cell Membrane
Animal Disease Models
5 Citations (Scopus)

Scillapersicene: a new homoisoflavonoid with cytotoxic activity from the bulbs of Scilla persica HAUSSKN

Hafez Ghoran, S., Saeidnia, S., Babaei, E., Kiuchi, F. & Hussain, H., 2015 Jun 30, (Accepted/In press) In : Natural Product Research.

Research output: Contribution to journalArticle

Scilla
bulbs
Energy gap
Cells
cell lines
11 Citations (Scopus)

Structural basis for the inhibition of voltage-dependent K+ channel by gating modifier toxin

Ozawa, S. I., Kimura, T., Nozaki, T., Harada, H., Shimada, I. & Osawa, M., 2015 Sep 18, In : Scientific Reports. 5, 14226.

Research output: Contribution to journalArticle

Membrane Potentials
Action Potentials
Permeability
Fluorescence
Amino Acids
2 Citations (Scopus)

Synthesis of a new glycosphingolipid, neurosporaside, from Neurospora crassa

Ohtsuka, I., Hada, N., Kanemaru, M., Fujii, T., Atsumi, T. & Kakiuchi, N., 2015 Mar 2, In : Carbohydrate Research. 404, p. 9-16 8 p.

Research output: Contribution to journalArticle

Glycosphingolipids
Neurospora crassa
Sulfonic Acids
Oligosaccharides
Derivatives

Synthesis of model compounds related to linear β-d-(1→6)-galactosyl side-chains of polysaccharides from astragalus mongholicus bunge

Hada, N., Shimura, R., Hakamata, K., Kiyohara, H., Yamada, H., Takeda, A. & Kiuchi, F., 2015, In : Heterocycles. 90, 1, p. 563-578 16 p.

Research output: Contribution to journalArticle

Galactans
Glycosylation
Polysaccharides
9 Citations (Scopus)

Temperature-responsive solid-phase extraction column for biological sample pretreatment

Akimaru, M., Okubo, K., Hiruta, Y. & Kanazawa, H., 2015, In : Analytical Sciences. 31, 9, p. 881-886 6 p.

Research output: Contribution to journalArticle

Hydrogels
Acrylamide
Phenytoin
Theophylline
Serum Albumin
24 Citations (Scopus)

The effects of anionic electrolytes and human serum albumin on the LCST of poly(N-isopropylacrylamide)-based temperature-responsive copolymers

Hiruta, Y., Nagumo, Y., Suzuki, Y., Funatsu, T., Ishikawa, Y. & Kanazawa, H., 2015 Aug 1, In : Colloids and Surfaces B: Biointerfaces. 132, p. 299-304 6 p.

Research output: Contribution to journalArticle

albumins
Serum Albumin
serums
Electrolytes
copolymers