Faculty of Pharmacy

Research Output 1975 2020

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2020

Cell uptake and anti-tumor effect of liposomes containing encapsulated paclitaxel-bound albumin against breast cancer cells in 2D and 3D cultured models

Okamoto, Y., Taguchi, K., Imoto, S., Giam Chuang, V. T., Yamasaki, K. & Otagiri, M., 2020 Feb, In : Journal of Drug Delivery Science and Technology. 55, 101381.

Research output: Contribution to journalArticle

Paclitaxel
Liposomes
Bovine Serum Albumin
Breast Neoplasms
Neoplasms

Thermoresponsive anionic copolymer brush-grafted surfaces for cell separation

Nagase, K., Uchikawa, N., Hirotani, T., Akimoto, A. M. & Kanazawa, H., 2020 Jan 1, In : Colloids and Surfaces B: Biointerfaces. 185, 110565.

Research output: Contribution to journalArticle

Cell Separation
brushes
Brushes
copolymers
Polymers
2019
4 Citations (Scopus)

Adsorption-Desorption Control of Fibronectin in Real Time at the Liquid/Polymer Interface on a Quartz Crystal Microbalance by Thermoresponsivity

Li, J., Kaku, T., Tokura, Y., Matsukawa, K., Homma, K., Nishimoto, T., Hiruta, Y., Akimoto, A. M., Nagase, K., Kanazawa, H. & Shiratori, S., 2019 Jan 1, In : Biomacromolecules.

Research output: Contribution to journalArticle

Quartz crystal microbalances
Fibronectins
Desorption
Polymers
Adsorption

Age-associated theophylline metabolic activity corresponds to the ratio of 1,3-dimethyluric acid to theophylline in mice

Kuroda, Y., Taguchi, K., Enoki, Y., Matsumoto, K., Hori, S. & Kizu, J., 2019 Jan 1, In : Biological and Pharmaceutical Bulletin. 42, 8, p. 1423-1427 5 p.

Research output: Contribution to journalArticle

Open Access
Theophylline
Acids
Serum
1,3-dimethyluric acid
Aptitude

Age-Related Trends in Home Blood Pressure, Home Pulse Rate, and Day-to-Day Blood Pressure and Pulse Rate Variability Based on Longitudinal Cohort Data: The Ohasama Study

Satoh, M., Metoki, H., Asayama, K., Murakami, T., Inoue, R., Tsubota-Utsugi, M., Matsuda, A., Hirose, T., Hara, A., Obara, T., Kikuya, M., Nomura, K., Hozawa, A., Imai, Y. & Ohkubo, T., 2019 Aug 6, In : Journal of the American Heart Association. 8, 15, e012121.

Research output: Contribution to journalArticle

Open Access
Heart Rate
Blood Pressure
Sex Characteristics
Linear Models
Japan
1 Citation (Scopus)

Airway M Cells arise in the lower airway due to RANKL signaling and reside in the bronchiolar epithelium associated with iBALT in murine models of respiratory disease

Kimura, S., Mutoh, M., Hisamoto, M., Saito, H., Takahashi, S., Asakura, T., Ishii, M., Nakamura, Y., Iida, J., Hase, K. & Iwanaga, T., 2019 Jan 1, In : Frontiers in Immunology. 10, JUN, 1323.

Research output: Contribution to journalArticle

Open Access
Lymphoid Tissue
Bronchi
Epithelium
Respiratory System
Glycoproteins

Analyzing Upward Deviation of Actual vs Predicted Drug Sales in Japan for a Reasonable Drug-Pricing Policy

Shibata, S., Fukumoto, D., Suzuki, T. & Ozaki, K., 2019 Jan 1, (Accepted/In press) In : Therapeutic Innovation and Regulatory Science.

Research output: Contribution to journalArticle

Japan
Costs and Cost Analysis
Pharmaceutical Preparations
Health Expenditures
Drug Costs

A Nationwide, Multicenter Registry Study of Antiemesis for Carboplatin-Based Chemotherapy-Induced Nausea and Vomiting in Japan

Iihara, H., Shimokawa, M., Hayashi, T., Kawazoe, H., Saeki, T., Aiba, K. & Tamura, K., 2019 Jan 1, (Accepted/In press) In : Oncologist.

Research output: Contribution to journalArticle

Open Access
Carboplatin
Nausea
Multicenter Studies
Vomiting
Registries
2 Citations (Scopus)

A partial agonist for retinoid X receptor mitigates experimental colitis

Masayoshi, O., Masaki, W., Narumi, I., Koichiro, S., Kei, T., Masato, H., Takahiro, Y., Aiko, E., Osamu, S., Midori, N., Michiko, F., Makoto, M., Takahashi, D., Yukihiro, F., Hiroki, K. & Koji, H., 2019 Feb 19, In : International Immunology. 31, 4, p. 251-262 12 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Colitis
Cytoplasmic and Nuclear Receptors
Ulcerative Colitis
Peroxisome Proliferator-Activated Receptors

A phenylphthalimide derivative, TC11, induces apoptosis by degrading MCL1 in multiple myeloma cells

Ichikawa, D., Nakamura, M., Murota, W., Osawa, S., Matsushita, M., Yanagawa, H. & Hattori, Y., 2019 Jan 1, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

Multiple Myeloma
Apoptosis
Derivatives
Degradation
Caspase 9

Bidirectional crosstalk between neutrophils and adipocytes promotes adipose tissue inflammation

Watanabe, Y., Nagai, Y., Honda, H., Okamoto, N., Yanagibashi, T., Ogasawara, M., Yamamoto, S., Imamura, R., Takasaki, I., Hara, H., Sasahara, M., Arita, M., Hida, S., Taniguchi, S., Suda, T. & Takatsu, K., 2019 Nov 1, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 11, p. 11821-11835 15 p.

Research output: Contribution to journalArticle

Crosstalk
Adipocytes
Adipose Tissue
White Adipose Tissue
Interleukin-1

Cardiac Pacemaker Cells Generate Cardiomyocytes from Fibroblasts in Long-Term Cultures

Kiuchi, S., Usami, A., Shimoyama, T., Otsuka, F., Yamaguchi, S., Nakamura, T., Suzuki, S. & Ono, K., 2019 Dec 1, In : Scientific reports. 9, 1, 15174.

Research output: Contribution to journalArticle

Open Access
Cardiac Myocytes
Sinoatrial Node
Fibroblasts
Guinea
Coculture Techniques

CD44-targeting nanocarriers for cancer treatment

Yamanouchi, T. & Kanazawa, H., 2019 Jan 1, In : Drug Delivery System. 34, 1, p. 38-45 8 p.

Research output: Contribution to journalArticle

Open Access
Hyaluronic Acid
Research
CD44 Antigens
Neoplasms
Neoplastic Stem Cells

Characteristic differences of cell sheets composed of mesenchymal stem cells with different tissue origins

Nakao, M., Inanaga, D., Nagase, K. & Kanazawa, H., 2019 Dec 1, In : Regenerative Therapy. 11, p. 34-40 7 p.

Research output: Contribution to journalArticle

Open Access
Stem cells
Mesenchymal Stromal Cells
Tissue
Cell culture
Cell Culture Techniques

Characterization of lipid profiles after dietary intake of polyunsaturated fatty acids using integrated untargeted and targeted lipidomics

Naoe, S., Tsugawa, H., Takahashi, M., Ikeda, K. & Arita, M., 2019 Oct, In : Metabolites. 9, 10, 241.

Research output: Contribution to journalArticle

Open Access
Unsaturated Fatty Acids
Lipids
Arachidonic Acid
Tissue
Eicosapentaenoic Acid
2 Citations (Scopus)
Lipopolysaccharides
Nitric Oxide
Acylation
Hydroxylation
Butyrates
1 Citation (Scopus)

Circulating microRNA-1246 as a possible biomarker for early tumor recurrence of hepatocellular carcinoma

Chuma, M., Toyoda, H., Matsuzaki, J., Saito, Y., Kumada, T., Tada, T., Kaneoka, Y., Maeda, A., Yokoo, H., Ogawa, K., Kamiyama, T., Taketomi, A., Matsuno, Y., Yazawa, K., Takeda, K., Kunisaki, C., Ogushi, K., Moriya, S., Hara, K., Nozaki, A. & 6 others, Kondo, M., Fukuda, H., Numata, K., Tanaka, K., Maeda, S. & Sakamoto, N., 2019 Jul 1, In : Hepatology Research. 49, 7, p. 810-822 13 p.

Research output: Contribution to journalArticle

Tumor Biomarkers
MicroRNAs
Hepatocellular Carcinoma
Recurrence
Neoplasms
1 Citation (Scopus)

Collateral sensitivity of drug-resistant ABCB5- and mutation-activated EGFR overexpressing cells towards resveratrol due to modulation of SIRT1 expression

Saeed, M. E. M., Rahama, M., Kuete, V., Dawood, M., Elbadawi, M., Sugimoto, Y. & Efferth, T., 2019 Jun 1, In : Phytomedicine. 59, 152890.

Research output: Contribution to journalArticle

Sirtuin 1
Mutation
Pharmaceutical Preparations
Multiple Drug Resistance
Cluster Analysis

Combination with l-menthol enhances transdermal penetration of indomethacin solid nanoparticles

Nagai, N., Ogata, F., Yamaguchi, M., Fukuoka, Y., Otake, H., Nakazawa, Y. & Kawasaki, N., 2019 Aug 1, In : International journal of molecular sciences. 20, 15, 3644.

Research output: Contribution to journalArticle

Open Access
menthol
Menthol
Indomethacin
Nanoparticles
Gels

Crosslinked Poly(N-Isopropylacrylamide)-Based Microfibers as Cell Manipulation Materials with Prompt Cell Detachment

Konishi, T., Mizutani Akimoto, A., Nishimoto, T., Tokura, Y., Tenjimbayashi, M., Homma, K., Matsukawa, K., Kaku, T., Hiruta, Y., Nagase, K., Kanazawa, H. & Shiratori, S., 2019 Jan 1, (Accepted/In press) In : Macromolecular Rapid Communications. 1900464.

Research output: Contribution to journalArticle

Cell adhesion
Temperature
Intelligent materials
Fibers
Swelling

Cytotoxicity of 40 Egyptian plant extracts targeting mechanisms of drug-resistant cancer cells

Hegazy, M. E. F., Abdelfatah, S., Hamed, A. R., Mohamed, T. A., Elshamy, A. A., Saleh, I. A., Reda, E. H., Abdel-Azim, N. S., Shams, K. A., Sakr, M., Sugimoto, Y., Paré, P. W. & Efferth, T., 2019 Jun 1, In : Phytomedicine. 59, 152771.

Research output: Contribution to journalArticle

Plant Extracts
Drug Delivery Systems
Centaurea
Multiple Drug Resistance
Pulicaria

Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells

Saeed, M. E. M., Boulos, J. C., Elhaboub, G., Rigano, D., Saab, A., Loizzo, M. R., Hassan, L. E. A., Sugimoto, Y., Piacente, S., Tundis, R., Yagi, S., Khalid, H. & Efferth, T., 2019 Sep 1, In : Phytomedicine. 62, 152945.

Research output: Contribution to journalArticle

Neoplasms
P-Glycoprotein
Cucurbitacins
Epidermal Growth Factor Receptor
Breast Neoplasms

Development of an electronic medical record-based algorithm to identify patients with Stevens-Johnson syndrome and toxic epidermal necrolysis in Japan

Fukasawa, T., Takahashi, H., Kameyama, N., Fukuda, R., Furuhata, S., Tanemura, N., Amagai, M. & Urushihara, H., 2019 Jan 1, In : PloS one. 14, 8, e0221130.

Research output: Contribution to journalArticle

Open Access
Electronic medical equipment
Stevens-Johnson Syndrome
Electronic Health Records
Poisons
electronics
1 Citation (Scopus)

Distinct roles of α7 nAChRs in antigen-presenting cells and CD4+ T cells in the regulation of T cell differentiation

Mashimo, M., Komori, M., Matsui, Y. Y., Murase, M. X., Fujii, T., Takeshima, S., Okuyama, H., Ono, S., Moriwaki, Y., Misawa, H. & Kawashima, K., 2019 Jan 1, In : Frontiers in Immunology. 10, MAY, 1102.

Research output: Contribution to journalArticle

Open Access
Nicotinic Receptors
Antigen-Presenting Cells
Cell Differentiation
T-Lymphocytes
Ovalbumin
6 Citations (Scopus)

Dysregulated fatty acid metabolism in nasal polyp-derived eosinophils from patients with chronic rhinosinusitis

Miyata, J., Fukunaga, K., Kawashima, Y., Watanabe, T., Saitoh, A., Hirosaki, T., Araki, Y., Kikawada, T., Betsuyaku, T., Ohara, O. & Arita, M., 2019 Jan 1, In : Allergy: European Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Nasal Polyps
Eosinophils
Fatty Acids
Arachidonate 15-Lipoxygenase
Lipid Metabolism
Open Access
Students
Pharmacy Education
Pharmaceutical Preparations
Learning
Psychology
3 Citations (Scopus)

Effect of polymer phase transition behavior on temperature-responsive polymer-modified liposomes for siRNA transfection

Nagase, K., Hasegawa, M., Ayano, E., Maitani, Y. & Kanazawa, H., 2019 Jan 2, In : International Journal of Molecular Sciences. 20, 2, 430.

Research output: Contribution to journalArticle

Liposomes
Phase Transition
Small Interfering RNA
Transfection
Polymers
Charcoal
Phenobarbital
Drug Interactions
Food
Pharmaceutical Preparations
1 Citation (Scopus)
Open Access
Endocytosis
Indomethacin
Nanoparticles
Nystatin
Pharmaceutical Preparations

Enhanced dissolution and oral bioavailability of praziquantel by emulsification with human serum albumin followed by spray drying

Yamasaki, K., Taguchi, K., Nishi, K., Otagiri, M. & Seo, H., 2019 Nov 1, In : European Journal of Pharmaceutical Sciences. 139, 105064.

Research output: Contribution to journalArticle

Praziquantel
Serum Albumin
Biological Availability
Emulsions
Solubility

Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging

Uchida, R., Saito, Y., Nogami, K., Kajiyama, Y., Suzuki, Y., Kawase, Y., Nakaoka, T., Muramatsu, T., Kimura, M. & Saito, H., 2019 Dec 1, In : npj Aging and Mechanisms of Disease. 5, 1, 1.

Research output: Contribution to journalArticle

Organoids
Epigenomics
Nicotinamide Mononucleotide
Stem Cells
Cell Aging

Epstein-Barr Virus Genome Replication as a Molecular Target for Cancer Therapy

Noguchi, K., 2019 Jan 1, In : Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 139, 1, p. 63-67 5 p.

Research output: Contribution to journalArticle

Virus Replication
Human Herpesvirus 4
Genome
Nuclear Antigens
Neoplasms
Organoids
Biliary Tract Neoplasms
Pancreatic Neoplasms
Neoplasms
gemcitabine
4 Citations (Scopus)

Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma

Saito, Y., Muramatsu, T., Kanai, Y., Ojima, H., Sukeda, A., Hiraoka, N., Arai, E., Sugiyama, Y., Matsuzaki, J., Uchida, R., Yoshikawa, N., Furukawa, R. & Saito, H., 2019 Apr 23, In : Cell Reports. 27, 4, p. 1265-1276.e4

Research output: Contribution to journalArticle

Open Access
Organoids
Preclinical Drug Evaluations
Biliary Tract
Screening
Biomarkers

Evaluation for optimal dosing of vancomycin in patients with different physical types

Hashimoto, M., Iketani, O., Ichinose, N., Enoki, Y., Taguchi, K., Uno, S., Uwamino, Y., Hasegawa, N. & Matsumoto, K., 2019 Jan 1, In : Journal of Infection and Chemotherapy.

Research output: Contribution to journalArticle

Vancomycin
Body Mass Index
Obesity
Body Weight

Evaluation of the expression time of ganciclovir-induced adverse events using JADER and FAERS

Ando, G., Taguchi, K., Enoki, Y., Yokoyama, Y., Kizu, J. & Matsumoto, K., 2019 Jan 1, In : Biological and Pharmaceutical Bulletin. 42, 11, p. 1799-1804 6 p.

Research output: Contribution to journalArticle

Open Access
Ganciclovir
Drug-Related Side Effects and Adverse Reactions
Databases
Acute Kidney Injury
Thrombocytopenia
Ceftriaxone
Gallstones
Salts
Calcium
Drug-Related Side Effects and Adverse Reactions

Expression of precipitating factors of pruritus found in humans in an imiquimod-induced psoriasis mouse model

Oishi, N., Iwata, H., Kambe, N., Kobayashi, N., Fujimoto, K., Sato, H., Hisaka, A., Ueno, K. & Yamaura, K., 2019 Jun 1, In : Heliyon. 5, 6, e01981.

Research output: Contribution to journalArticle

Open Access
imiquimod
Precipitating Factors
Pruritus
Psoriasis
Nerve Growth Factor
3 Citations (Scopus)

Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses

Nagai, M., Noguchi, R., Takahashi, D., Morikawa, T., Koshida, K., Komiyama, S., Ishihara, N., Yamada, T., Kawamura, Y. I., Muroi, K., Hattori, K., Kobayashi, N., Fujimura, Y., Hirota, M., Matsumoto, R., Aoki, R., Tamura-Nakano, M., Sugiyama, M., Katakai, T., Sato, S. & 3 others, Takubo, K., Dohi, T. & Hase, K., 2019 Aug 22, In : Cell. 178, 5, p. 1072-1087.e14

Research output: Contribution to journalArticle

Mucosal Immunity
Peyer's Patches
Fasting
B-Lymphocytes
Cells
1 Citation (Scopus)

Further Evidence Regarding the Important Role of Chlorine Atoms of Aripiprazole on Binding to the Site II Area of Human Albumin

Sakurama, K., Nishi, K., Imoto, S., Hashimoto, M., Komatsu, T., Morita, Y., Taguchi, K., Otagiri, M. & Yamasaki, K., 2019 Jan 1, (Accepted/In press) In : Journal of Pharmaceutical Sciences.

Research output: Contribution to journalArticle

Chlorine
Albumins
Binding Sites
Circular Dichroism
Aripiprazole
1 Citation (Scopus)

Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

Katsuda, T., Matsuzaki, J., Yamaguchi, T., Yamada, Y., Prieto-Vila, M., Hosaka, K., Takeuchi, A., Saito, Y. & Ochiya, T., 2019 Aug 8, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Hepatocytes
Stem Cells
Liver
Cell Transplantation
Liver Transplantation

Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids

Miyamoto, J., Igarashi, M., Watanabe, K., Karaki, S. I., Mukouyama, H., Kishino, S., Li, X., Ichimura, A., Irie, J., Sugimoto, Y., Mizutani, T., Sugawara, T., Miki, T., Ogawa, J., Drucker, D. J., Arita, M., Itoh, H. & Kimura, I., 2019 Dec 1, In : Nature communications. 10, 1, 4007.

Research output: Contribution to journalArticle

Open Access
obesity
diets
fatty acids
Nutrition
Unsaturated Fatty Acids

Identification of glycyrrhizin metabolites in humans and of a potential biomarker of liquorice-induced pseudoaldosteronism: a multi-centre cross-sectional study

Takahashi, K., Yoshino, T., Maki, Y., Ishiuchi, K., Namiki, T., Ogawa-Ochiai, K., Minamizawa, K., Makino, T., Nakamura, T., Mimura, M. & Watanabe, K., 2019 Nov 1, In : Archives of Toxicology. 93, 11, p. 3111-3119 9 p.

Research output: Contribution to journalArticle

Liddle Syndrome
Glycyrrhizic Acid
Glycyrrhiza
Biomarkers
Metabolites

IFPA meeting 2018 workshop report II: Abnormally invasive placenta; inflammation and infection; preeclampsia; gestational trophoblastic disease and drug delivery

Albrecht, C., Chamley, L., Charnock-Jones, D. S., Collins, S., Fujiwara, H., Golos, T., Grayo, S., Hannan, N., Harris, L., Ichizuka, K., Illsley, N. P., Iwashita, M., Kallol, S., Al-Khan, A., Lash, G., Nagamatsu, T., Nakashima, A., Niimi, K., Nomoto, M., Redman, C. & 8 others, Saito, S., Tanimura, K., Tomi, M., Usui, H., Vatish, M., Wolfe, B., Yamamoto, E. & O'Tierney-Ginn, P., 2019 Jan 1, In : Placenta.

Research output: Contribution to journalArticle

Gestational Trophoblastic Disease
Pre-Eclampsia
Placenta
Inflammation
Education
Open Access
Human Influenza
Japan
Vaccination
Datasets
Occupational Health

Inhibitory kinetics of fruit components on CYP2C19 activity

Seki, H., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2019 Jan 1, In : Drug Metabolism And Pharmacokinetics.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Fruit
Citrus paradisi
Food-Drug Interactions
Omeprazole
1 Citation (Scopus)

Investigation of anti-tumor effect of doxorubicin-loaded human serum albumin nanoparticles prepared by a desolvation technique

Kimura, K., Yamasaki, K., Nishi, K., Taguchi, K. & Otagiri, M., 2019 Jun 1, In : Cancer Chemotherapy and Pharmacology. 83, 6, p. 1113-1120 8 p.

Research output: Contribution to journalArticle

Serum Albumin
Nanoparticles
Doxorubicin
Tumors
Neoplasms

LAT1-Targeting Thermoresponsive Liposomes for Effective Cellular Uptake by Cancer Cells

Maekawa-Matsuura, M., Fujieda, K., Maekawa, Y., Nishimura, T., Nagase, K. & Kanazawa, H., 2019 Apr 8, In : ACS Omega. 4, 4, p. 6443-6451 9 p.

Research output: Contribution to journalArticle

Open Access
Amino Acid Transport Systems
Liposomes
Amino acids
Cells
Tyrosine

LC–MS analysis of saponins of Achyranthes root in the Japanese market

Kuwada, K., Kawase, S., Nakata, K., Shinya, N., Narukawa, Y., Fuchino, H., Kawahara, N. & Kiuchi, F., 2019 Jan 1, (Accepted/In press) In : Journal of Natural Medicines.

Research output: Contribution to journalArticle

Achyranthes
Saponins
1-Butanol
Water
Peroxides
Biological Products
Lipase
Hydrolysis
Esters
Candida antarctica lipase B