Faculty of Pharmacy

Research Output 1975 2020

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2 Citations (Scopus)

(-)-Benzyl 2,3-dideoxy-β-d-erythro-hex-2-enopyranoside

Ohba, S., Okazaki, H., Ueda, Y., Hanaya, K., Shoji, M. & Sugai, T., 2013 Dec, In : Acta Crystallographica Section E: Structure Reports Online. 69, 12

Research output: Contribution to journalArticle

Sugars
Conformations
Hydrogen bonds
Crystals
Molecules
1 Citation (Scopus)

[3H]2-(4-Phenylpiperidino)cyclohexanol (AH5183) binding to synaptosomes and subcellular fractions obtained from rat brain

Suzuki, T., Kashima, Y., Fujimoto, K. & Kawashima, K., 1993 Jul 9, In : Neuroscience Letters. 157, 1, p. 72-74 3 p.

Research output: Contribution to journalArticle

Subcellular Fractions
Synaptosomes
Synaptic Vesicles
Brain
Binding Sites
2 Citations (Scopus)

[A study on comparison of learning effects between a board game and a lecture about infection control].

Kawamura, H., Kishimoto, K., Matsuda, T. & Fukushima, N., 2014, In : Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 134, 7, p. 839-849 11 p.

Research output: Contribution to journalArticle

Infection Control
Learning
Motivation
Pharmacists
Education

[Classification criteria for severity of adverse drug reactions].

Hashiguchi, M. & Mochizuki, M., 2012 Aug, In : Nihon rinsho. Japanese journal of clinical medicine. 70 Suppl 6, p. 37-44 8 p.

Research output: Contribution to journalArticle

Drug-Related Side Effects and Adverse Reactions
2 Citations (Scopus)
Hepacivirus
Japan
Syringes
Transfusion Medicine
Infection
2 Citations (Scopus)

[Patients' reaction to pharmacists wearing a mask during their consultations].

Tamura, E., Kishimoto, K. & Fukushima, N., 2013, In : Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 133, 6, p. 737-745 9 p.

Research output: Contribution to journalArticle

Masks
Pharmacists
Referral and Consultation
Logistic Models
Tokyo

[Reporting system for adverse drug reactions and infections].

Hashiguchi, M. & Mochizuki, M., 2012 Aug, In : Nihon rinsho. Japanese journal of clinical medicine. 70 Suppl 6, p. 29-35 7 p.

Research output: Contribution to journalArticle

Adverse Drug Reaction Reporting Systems
Disease Notification
Japan
Infection

[Treatment of refractory and relapsed multiple myeloma].

Hattori, Y., 2012 Apr, In : Nihon rinsho. Japanese journal of clinical medicine. 70 Suppl 2, p. 597-602 6 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Recurrence
6 Citations (Scopus)

12-OH-17,18-Epoxyeicosatetraenoic acid alleviates eosinophilic airway inflammation in murine lungs

Mochimaru, T., Fukunaga, K., Miyata, J., Matsusaka, M., Masaki, K., Kabata, H., Ueda, S., Suzuki, Y., Goto, T., Urabe, D., Inoue, M., Isobe, Y., Arita, M. & Betsuyaku, T., 2017, (Accepted/In press) In : Allergy: European Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Eicosapentaenoic Acid
Inflammation
Lung
Acids
Eosinophils
2 Citations (Scopus)

12′-Hydroxyl group remarkably reduces Roridin E cytotoxicity

Oda, T., Xu, J., Ukai, K., Nakazawa, T. & Namikoshi, M., 2010, In : Mycoscience. 51, 4, p. 317-320 4 p.

Research output: Contribution to journalArticle

roridins
cytotoxicity
Myrothecium roridum
trichothecenes
Chinese hamsters
8 Citations (Scopus)

2,2′-Pyridoin derivatives protect HL-60 cells against oxidative stress

Hatanaka, M., Nishizawa, C., Kakinoki, T., Takahashi, K., Nakamura, S. & Mashino, T., 2008 Oct 1, In : Bioorganic and Medicinal Chemistry Letters. 18, 19, p. 5290-5293 4 p.

Research output: Contribution to journalArticle

Oxidative stress
HL-60 Cells
Oxidative Stress
Derivatives
Antioxidants
4 Citations (Scopus)

2-5 AS activity in serum and peripheral blood mononuclear cells for chronic active hepatitis C and the relationship to clinical outcome of interferon therapy

Toda, K., Kumagai, N., Iwabuchi, N., Suzuki, T., Saito, H., Morizane, T., Hibi, T., Ishii, H. & Tsuchimoto, K., 1997, In : Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology. 20, 5, p. 428-436 9 p.

Research output: Contribution to journalArticle

Chronic Hepatitis C
Chronic Hepatitis
Ligases
Interferons
Blood Cells
10 Citations (Scopus)
Griseofulvin
Stereochemistry
Deuterium
Penicillium
Biosynthesis
13 Citations (Scopus)

6-Mercaptopurine transport by equilibrative nucleoside transporters in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBTs

Lee, N. Y., Sai, Y., Nakashima, E., Ohtsuki, S. & Kang, Y. S., 2011 Sep, In : Journal of Pharmaceutical Sciences. 100, 9, p. 3773-3782 10 p.

Research output: Contribution to journalArticle

Nucleoside Transport Proteins
6-Mercaptopurine
Trophoblasts
Cell Line
Placenta
9 Citations (Scopus)

7-Azabicyclo[2.2.1]heptane as a structural motif to block mutagenicity of nitrosamines

Ohwada, T., Ishikawa, S., Mine, Y., Inami, K., Yanagimoto, T., Karaki, F., Kabasawa, Y., Otani, Y. & Mochizuki, M., 2011 Apr 15, In : Bioorganic and Medicinal Chemistry. 19, 8, p. 2726-2741 16 p.

Research output: Contribution to journalArticle

Nitrosamines
Hydroxylation
7-azabicyclo(2.2.1)heptane
Dimethylnitrosamine
Heptanes
5 Citations (Scopus)

A2 H NMR study on alteration of the membrane organization of mouse b16 melanoma cells treated with 12-O-tetradecanoylphorbol-13-acetate

Sugimoto, Y., Saito, H., Tabeta, R. & Kodama, M., 1986 Oct, In : Journal of Biochemistry. 100, 4, p. 867-874 8 p.

Research output: Contribution to journalArticle

Melanoma
Experimental Melanomas
Tetradecanoylphorbol Acetate
varespladib methyl
Mouse
9 Citations (Scopus)
Magnetic resonance spectroscopy
Deuterium Oxide
Griseofulvin
Sodium Acetate
Starters

A 50-year-old man with ulcerative colitis and severe anemia.

Saito, H., Inoue, J., Yamaguchi, W., Tashiro, H., Miura, S., Hibi, T., Tsuchiya, M., Handa, M., Nakatsuka, S. & Kuramochi, S., 1992 Dec, In : Keio Journal of Medicine. 41, 4, p. 225-232 8 p.

Research output: Contribution to journalArticle

Autoimmune Hemolytic Anemia
Ulcerative Colitis
Blood Transfusion
Anemia
Shock
3 Citations (Scopus)

A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis

Niino, T., Tago, K., Yasuda, D., Takahashi, K., Mashino, T., Tamura, H. & Tago, M., 2018 Sep 1, In : Biochemical Pharmacology. 155, p. 182-197 16 p.

Research output: Contribution to journalArticle

Derivatives
Acetylcysteine
Cysteine
Chemical activation
Antioxidants
9 Citations (Scopus)

Aberrant trafficking of the high-affinity choline transporter in AP-3-deficient mice

Misawa, H., Fujigaya, H., Nishimura, T., Moriwaki, Y., Okuda, T., Kawashima, K., Nakata, K., Ruggiero, A. M., Blakely, R. D., Nakatsu, F. & Ohno, H., 2008 Jun, In : European Journal of Neuroscience. 27, 12, p. 3109-3117 9 p.

Research output: Contribution to journalArticle

Proteins
Synaptic Vesicles
Presynaptic Terminals
choline transporter
Synaptophysin
3 Citations (Scopus)

A bis-malonic acid fullerene derivative significantly suppressed IL-33-induced IL-6 expression by inhibiting NF-κB activation

Tago, M., Miyagawa, Y., Ueda, F., Mashino, T., Moriwaki, Y., Tago, K., Kasahara, T. & Tamura, H., 2016 Nov 1, In : International Immunopharmacology. 40, p. 254-264 11 p.

Research output: Contribution to journalArticle

Fullerenes
Interleukin-6
Mast Cells
malonic acid
Interleukin-33
7 Citations (Scopus)

Absolute liquid scintillation counting of35S and45Ca using a modified integral counting method

Homma, Y., Morita-Murase, Y. & Handa, K., 1994 Jul, In : Journal of Radioanalytical and Nuclear Chemistry Letters. 187, 5, p. 367-374 8 p.

Research output: Contribution to journalArticle

Scintillation Counting
Disintegration
Scintillation
Scintillation counters
Liquids
2 Citations (Scopus)
Scintillation Counting
Disintegration
Scintillation
Scintillation counters
Liquids

A case of acute pancreatitis induced by telaprevir in the anti-HCV treatment with peginterferon and ribavirin

Matsushita, M., Ebinuma, H., Fukuhara, S., Minami, K., Minami, K., Nakamoto, N., Funakoshi, S., Kanai, T., Saito, H. & Hibi, T., 2013 May 30, In : Acta Hepatologica Japonica. 54, 5, p. 340-346 7 p.

Research output: Contribution to journalArticle

Ribavirin
Pancreatitis
Therapeutics
Gabexate
RNA

A case of fulminant hepatitis B occurred in an asymptomatic hepatitis B virus carrier

Ooishi, T., Kumagai, N., Iwabuchi, N., Tsuchimoto, K., Kuramochi, S., Tada, S., Tsunematsu, S., Saito, H., Morizane, T. & Ishii, H., 1995, In : Acta Hepatologica Japonica. 36, 12, p. 706-711 6 p.

Research output: Contribution to journalArticle

Hepatitis B e Antigens
DNA-Directed DNA Polymerase
Hepatitis B
Hepatitis B virus
Hepatitis
1 Citation (Scopus)

A case of fulminant hepatitis E treated with artificial liver support

Fujiyama, Y., Yamagishi, Y., Kikuchi, M., Shimoji, K., Kato, S., Nagata, H., Saito, H., Hibi, T. & Mishiro, S., 2007 Feb, In : Japanese Journal of Gastroenterology. 104, 2, p. 219-225 7 p.

Research output: Contribution to journalArticle

Artificial Liver
Hepatitis E
Hepatitis E virus
China
Hepatitis Delta Virus
4 Citations (Scopus)

A case of parathyroid hormone-related peptide producing gallbladder carcinoma and establishment of a cell line, PTHrP-GBK

Ebinuma, H., Imaeda, H., Fukuda, Y., Miyaguchi, S., Yasui, T., Hoshino, T., Okamura, T., Ariwa, R. & Saito, H., 2002, In : Digestive Diseases and Sciences. 47, 1, p. 125-129 5 p.

Research output: Contribution to journalArticle

Cultured Tumor Cells
Gallbladder Neoplasms
Parathyroid Hormone-Related Protein
Hypercalcemia
Protein Biosynthesis

A case of pseudomembranous colitis with the detection of Klebsiella oxytoca and Clostridium innocuum in his stool

Saito, H., Miura, S., Kim, S., Komatsu, K., Sawaguchi, K., Watanabe, M., Asakura, H. & Tsuchiya, M., 1987 Apr, In : Japanese Journal of Gastroenterology. 84, 4, p. 909-914 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A case of severe cholestatic jaundice with hyperthyroidism successfully treated with methimazole

Ichikawa, H., Ebinuma, H., Tada, S., Ojiro, K., Yamagishi, Y., Tsukada, N., Hongou, E., Funae, O., Irie, R., Saito, H. & Hibi, T., 2009 Aug, In : Clinical Journal of Gastroenterology. 2, 4, p. 315-319 5 p.

Research output: Contribution to journalArticle

Methimazole
Obstructive Jaundice
Hyperthyroidism
Jaundice
Cholestasis
11 Citations (Scopus)

Acceptance of surrogate end points in clinical trials supporting approval of drugs for cancer treatment by the Japanese regulatory agency

Maeda, H. & Kurokawa, T., 2015 Jan 1, In : Annals of Oncology. 26, 1, p. 211-216 6 p.

Research output: Contribution to journalArticle

Drug Approval
Japan
Biomarkers
Clinical Trials
Pharmaceutical Preparations
4 Citations (Scopus)
geosmin
Enantiomers
enantiomers
synthesis
(4aS,5S)-(+)-4,4a,5,6,7,8-hexahydro-5-hydroxy-4a-methylnaphthalen-2(3H)-one
44 Citations (Scopus)

Access to Wieland-Miescher ketone in an enantiomerically pure form by a kinetic resolution with yeast-mediated reduction

Fuhshuku, K. I., Funa, N., Akeboshi, T., Ohta, H., Hosomi, H., Ohba, S. & Sugai, T., 2000 Jan 14, In : Journal of Organic Chemistry. 65, 1, p. 129-135 7 p.

Research output: Contribution to journalArticle

Enantiomers
Ketones
Yeast
Kinetics
Naphthoquinones
80 Citations (Scopus)

Acetylcholine synthesis and muscarinic receptor subtype mRNA expression in T-lymphocytes

Kawashima, K., Fujii, T., Watanabe, Y. & Misawa, H., 1998 Mar 27, In : Life Sciences. 62, 17-18, p. 1701-1705 5 p.

Research output: Contribution to journalArticle

T-cells
Muscarinic Receptors
Acetylcholine
T-Lymphocytes
Messenger RNA
15 Citations (Scopus)

Acetylcholine synthesis and release in NIH3T3 cells coexpressing the high-affinity choline transporter and choline acetyltransferase

Fujii, T., Masai, M., Misawa, H., Okuda, T., Takada-Takatori, Y., Moriwaki, Y., Haga, T. & Kawashima, K., 2009 Oct, In : Journal of Neuroscience Research. 87, 13, p. 3024-3032 9 p.

Research output: Contribution to journalArticle

Choline O-Acetyltransferase
Acetylcholine
Choline
Hemicholinium 3
Cholinergic Neurons
4 Citations (Scopus)

Acetylcholine synthesis is modulated by acetylcholine content of cytosolic fraction but not by that of releasable fraction

Suzuki, T., Kashima, Y., Fujimoto, K. & Kawashima, K., 1992 Sep 14, In : Neuroscience Letters. 144, 1-2, p. 127-129 3 p.

Research output: Contribution to journalArticle

Acetylcholine
Synaptic Vesicles
Cytosol
Membranes

A chemical model of catechol-O-methyltransferase. II

Sugata, S. & Matsushima, Y., 1987, In : Journal of Pharmacobio-Dynamics. 10, 1

Research output: Contribution to journalArticle

Chemical Models
Catechol O-Methyltransferase
2 Citations (Scopus)

A chemical model of catechol-O-methyltransferase. Methylation of 3,4-dihydroxybenzaldehyde in aqueous solution

Sugata, S., Ishihara, S., Watanabe, Y., Itoh, Y. & Matsushima, Y., 1989, In : Chemical and Pharmaceutical Bulletin. 37, 5, p. 1143-1146 4 p.

Research output: Contribution to journalArticle

Benzaldehydes
Catechols
Chemical Models
Catechol O-Methyltransferase
Methylation
1 Citation (Scopus)

A chemical model of catechol-O-methyltransferase. Methylation of 3,4- dihydroxybenzaldehyde in methanol solution

Sugata, S., 1993, In : Chemical and Pharmaceutical Bulletin. 41, 6, p. 1007-1011 5 p.

Research output: Contribution to journalArticle

Chemical Models
Catechol O-Methyltransferase
Methylation
Catalysis
Methanol
1 Citation (Scopus)

A chemical model of catechol-o-methyltransferase. V

Sugata, S. & Matsushima, Y., 1991, In : Journal of Pharmacobio-Dynamics. 14, 11

Research output: Contribution to journalArticle

Chemical Models
Catechol O-Methyltransferase
12 Citations (Scopus)

A chemo-enzymatic elaboration of a quarternary chiral center: An alternative approach to the side chain of furaquinocin D

Akeboshi, T., Ohtsuka, Y., Sugai, T. & Ohta, H., 1998 Jun 25, In : Tetrahedron. 54, 26, p. 7387-7394 8 p.

Research output: Contribution to journalArticle

Lipase
Ether
Hydrolysis
Esters
Alcohols
7 Citations (Scopus)
Lipase
Costs and Cost Analysis
Costs
benzoquinone
hydroquinone
14 Citations (Scopus)

A Chemo-Enzymatic Synthesis of D-Allosamine Derivatives from Tri-O-acetyl- D-glucal

Sugai, T., Okazaki, H., Kuboki, A. & Ohta, H., 1997 Oct, In : Bulletin of the Chemical Society of Japan. 70, 10, p. 2535-2540 6 p.

Research output: Contribution to journalArticle

Calcium Gluconate
Lipase
Alcohols
Derivatives
Acetylation
26 Citations (Scopus)

Acidic catecholamine metabolites and 5-hydroxyindoleacetic acid in urine: The influence of diet

Mashige, F., Matsushima, Y., Kanazawa, H., Sakuma, I., Takai, N., Bessho, F. & Ohkubo, A., 1996, In : Annals of Clinical Biochemistry. 33, 1, p. 43-49 7 p.

Research output: Contribution to journalArticle

Hydroxyindoleacetic Acid
Vanilmandelic Acid
Vanillic Acid
Nutrition
Metabolites
2 Citations (Scopus)

A comment on the evaluation of equilibrium constants for α-tocopherol interactions with fatty acids by absorbance in the ultraviolet region

Sugata, S., Urano, S., Matsushima, Y. & Matsuo, M., 1988 Oct 14, In : Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism. 962, 3, p. 385-386 2 p.

Research output: Contribution to journalArticle

Tocopherols
Equilibrium constants
Fatty Acids
Ethanol
8 Citations (Scopus)

A copper-deficient form of mutant Cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis

Tokuda, E., Nomura, T., Ohara, S., Watanabe, S., Yamanaka, K., Morisaki, Y., Misawa, H. & Furukawa, Y., 2018 Jun 1, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 6, p. 2119-2130 12 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Copper
Metals
Zinc
Spinal Cord
111 Citations (Scopus)

Acoustic Radiation Force Impulse Elastography for fibrosis evaluation in patients with chronic hepatitis C: An international multicenter study

Sporea, I., Bota, S., Peck-Radosavljevic, M., Sirli, R., Tanaka, H., Iijima, H., Badea, R., Lupsor, M., Fierbinteanu-Braticevici, C., Petrisor, A., Saito, H., Ebinuma, H., Friedrich-Rust, M., Sarrazin, C., Takahashi, H., Ono, N., Piscaglia, F., Borghi, A., D'Onofrio, M., Gallotti, A. & 3 others, Ferlitsch, A., Popescu, A. & Danila, M., 2012 Dec, In : European Journal of Radiology. 81, 12, p. 4112-4118 7 p.

Research output: Contribution to journalArticle

Elasticity Imaging Techniques
Chronic Hepatitis C
Acoustics
Multicenter Studies
Fibrosis
20 Citations (Scopus)

Acoustic radiation force impulse imaging for assessing graft fibrosis after pediatric living donor liver transplantation: A pilot study

Tomita, H., Hoshino, K., Fuchimoto, Y., Ebinuma, H., Ohkuma, K., Tanami, Y., Du, W., Masugi, Y., Shimojima, N., Fujino, A., Kano, M., Fujimura, T., Ishihama, H., Shimizu, T., Tanabe, M., Saito, H., Sakamoto, M., Hibi, T., Kitagawa, Y. & Kuroda, T., 2013 Nov, In : Liver Transplantation. 19, 11, p. 1202-1213 12 p.

Research output: Contribution to journalArticle

Elasticity Imaging Techniques
Living Donors
Liver Transplantation
Fibrosis
Pediatrics
17 Citations (Scopus)
L-Amino Acid Oxidase
Stereoisomerism
Isoleucine
Isomers
Amino acids