Faculty of Pharmacy

Research Output 1975 2020

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2019

日米における適応的デザインを用いた臨床試験の現状

Translated title of the contribution: Application of adaptive designs in clinical trials in Japan and the United StatesYamakawa, N., Teramukai, S., Hatta, T. & Urushihara, H., 2019 Jan 1, In : Japanese Journal of Clinical Pharmacology and Therapeutics. 50, 4, p. 149-156 8 p.

Research output: Contribution to journalArticle

Japan
Clinical Trials
Databases
Pharmaceutical Preparations
2018
3 Citations (Scopus)

A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis

Niino, T., Tago, K., Yasuda, D., Takahashi, K., Mashino, T., Tamura, H. & Tago, M., 2018 Sep 1, In : Biochemical Pharmacology. 155, p. 182-197 16 p.

Research output: Contribution to journalArticle

Derivatives
Acetylcysteine
Cysteine
Chemical activation
Antioxidants
8 Citations (Scopus)

A copper-deficient form of mutant Cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis

Tokuda, E., Nomura, T., Ohara, S., Watanabe, S., Yamanaka, K., Morisaki, Y., Misawa, H. & Furukawa, Y., 2018 Jun 1, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 6, p. 2119-2130 12 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Copper
Metals
Zinc
Spinal Cord
7 Citations (Scopus)

Alveolar macrophages drive hepatocellular carcinoma lung metastasis by generating leukotriene B4

Nosaka, T., Baba, T., Tanabe, Y., Sasaki, S., Nishimura, T., Imamura, Y., Yurino, H., Hashimoto, S., Arita, M., Nakamoto, Y. & Mukaida, N., 2018 Mar 1, In : Journal of Immunology. 200, 5, p. 1839-1852 14 p.

Research output: Contribution to journalArticle

Leukotriene B4
Alveolar Macrophages
Hepatocellular Carcinoma
Neoplasm Metastasis
Lung

A major component of vitamin E, α-tocopherol inhibits the anti-tumor activity of crizotinib against cells transformed by EML4-ALK

Uchihara, Y., Kidokoro, T., Tago, K., Mashino, T., Tamura, H. & Tago, M., 2018 Apr 15, In : European Journal of Pharmacology. 825, p. 1-9 9 p.

Research output: Contribution to journalArticle

Tocopherols
Vitamin E
Neoplasms
Tocotrienols
Gene Fusion
3 Citations (Scopus)

Analysis of the Binding of Aripiprazole to Human Serum Albumin: The Importance of a Chloro-Group in the Chemical Structure

Sakurama, K., Kawai, A., Tuan Giam Chuang, V., Kanamori, Y., Osa, M., Taguchi, K., Seo, H., Maruyama, T., Imoto, S., Yamasaki, K. & Otagiri, M., 2018 Oct 22, In : ACS Omega. 3, 10, p. 13790-13797 8 p.

Research output: Contribution to journalArticle

Dialysis
Dichroism
Metabolites
Serum Albumin
Pharmacodynamics
2 Citations (Scopus)

A novel derivative (GTN024) from a natural product, komaroviquinone, induced the apoptosis of high-risk myeloma cells via reactive oxygen production and ER stress

Okayama, M., Kitabatake, S., Sato, M., Fujimori, K., Ichikawa, D., Matsushita, M., Suto, Y., Iwasaki, G., Yamada, T., Kiuchi, F., Hirao, M., Kunieda, H., Osada, M., Okamoto, S. & Hattori, Y., 2018 Nov 2, In : Biochemical and Biophysical Research Communications. 505, 3, p. 787-793 7 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Biological Products
Multiple Myeloma
Apoptosis
Oxygen
2 Citations (Scopus)

Anticancer Drug Prescription Patterns in Japan: Future Directions in Cancer Therapy

Shibata, S., Matsushita, M., Saito, Y. & Suzuki, T., 2018 Nov 1, In : Therapeutic Innovation and Regulatory Science. 52, 6, p. 718-723 6 p.

Research output: Contribution to journalArticle

Drug Prescriptions
Japan
Pharmaceutical Preparations
Neoplasms
Health Expenditures
6 Citations (Scopus)

Application of Hydrazine-Embedded Heterocyclic Compounds to High Voltage Rechargeable Lithium Organic Batteries

Shimizu, T., Yamamoto, K., Pandit, P., Yoshikawa, H. & Higashibayashi, S., 2018 Dec 1, In : Scientific Reports. 8, 1, 579.

Research output: Contribution to journalArticle

hydrazine
Heterocyclic Compounds
Lithium
Cathodes
Electrodes
Protein-Tyrosine Kinases
Phosphotransferases
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Physiological Stress
Endoplasmic Reticulum
6 Citations (Scopus)

Betulinic acid exerts cytotoxic activity against multidrug-resistant tumor cells via targeting autocrine motility factor receptor (AMFR)

Saeed, M. E. M., Mahmoud, N., Sugimoto, Y., Efferth, T. & Abdel-Aziz, H., 2018 May 15, In : Frontiers in Pharmacology. 9, MAY, 481.

Research output: Contribution to journalArticle

Autocrine Motility Factor Receptor
Neoplasms
National Cancer Institute (U.S.)
Pentacyclic Triterpenes
Pharmaceutical Preparations
21 Citations (Scopus)

Bile acid metabolism regulated by the gut microbiota promotes non-alcoholic steatohepatitis-associated hepatocellular carcinoma in mice

Yamada, S., Takashina, Y., Watanabe, M., Nagamine, R., Saito, Y., Kamada, N. & Saito, H., 2018 Jan 1, In : Oncotarget. 9, 11, p. 9925-9939 15 p.

Research output: Contribution to journalArticle

Fatty Liver
Bile Acids and Salts
Hepatocellular Carcinoma
Anti-Bacterial Agents
Liver
4 Citations (Scopus)

CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy

Tsugawa, H., Mori, H., Matsuzaki, J., Sato, A., Saito, Y., Imoto, M., Suematsu, M. & Suzuki, H., 2018 Jan 1, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalArticle

Lysosomal-Associated Membrane Protein 1
Low Density Lipoprotein Receptor-Related Protein-1
Autophagy
Helicobacter pylori
Actins

Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells

Fujiwara, C., Muramatsu, Y., Nishii, M., Tokunaka, K., Tahara, H., Ueno, M., Yamori, T., Sugimoto, Y. & Seimiya, H., 2018 Dec 1, In : Scientific Reports. 8, 1, 14827.

Research output: Contribution to journalArticle

Lamin Type A
Telomere
DNA Damage
Telomerase
Neoplasms
4 Citations (Scopus)

Characterization of the multimeric structure of poly(A)-binding protein on a poly(A) tail

Sawazaki, R., Imai, S., Yokogawa, M., Hosoda, N., Hoshino, S. I., Mio, M., Mio, K., Shimada, I. & Osawa, M., 2018 Dec 1, In : Scientific Reports. 8, 1, 19659.

Research output: Contribution to journalArticle

Poly(A)-Binding Proteins
Carrier Proteins
Molecules
Messenger RNA
Transmission electron microscopy
1 Citation (Scopus)

Chemoenzymatic approaches to the synthesis of the (1S,2R)-isomer of benzyl 2-hydroxycyclohexanecarboxylate

Tsunekawa, R., Hanaya, K., Higashibayashi, S., Shoji, M. & Sugai, T., 2018 Jan 1, In : Molecular Catalysis. 444, p. 84-89 6 p.

Research output: Contribution to journalArticle

Isomers
isomers
synthesis
Stereoisomerism
enzymes
5 Citations (Scopus)

Comparative effectiveness and safety of warfarin and dabigatran in patients with non-valvular atrial fibrillation in Japan: A claims database analysis

Koretsune, Y., Yamashita, T., Yasaka, M., Ono, Y., Hirakawa, T., Ishida, K., Kuroki, D., Sumida, T. & Urushihara, H., 2018 Jan 1, (Accepted/In press) In : Journal of Cardiology.

Research output: Contribution to journalArticle

Insurance Claim Review
Warfarin
Atrial Fibrillation
Japan
Databases
2 Citations (Scopus)

Comprehensive analysis of the mouse cytochrome P450 family responsible for omega-3 epoxidation of eicosapentaenoic acid

Isobe, Y., Itagaki, M., Ito, Y., Naoe, S., Kojima, K., Ikeguchi, M. & Arita, M., 2018 Dec 1, In : Scientific Reports. 8, 1, 7954.

Research output: Contribution to journalArticle

Eicosapentaenoic Acid
Cytochrome P-450 Enzyme System
Protein Isoforms
Oxygenases
Acids

Current Status of Onychomycosis Topical Therapy Conducted at Home

Yoneta, Y., Imazu, Y., Uchida, E., Yamaura, K. & Suzuki, J., 2018 Jan 1, In : Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 138, 5, p. 607-609 3 p.

Research output: Contribution to journalArticle

Onychomycosis
Home Care Services
Tinea Pedis
Pain
Community Health Nurses
2 Citations (Scopus)

Cytotoxicity of nimbolide towards multidrug-resistant tumor cells and hypersensitivity via cellular metabolic modulation

Mahmoud, N., Saeed, M. E. M., Sugimoto, Y., Klauck, S. M., Greten, H. J. & Efferth, T., 2018 Nov 1, In : Oncotarget. 9, 87, p. 35762-35779 18 p.

Research output: Contribution to journalArticle

Hypersensitivity
Neoplasms
Multiple Drug Resistance
P-Glycoprotein
Epidermal Growth Factor Receptor
4 Citations (Scopus)

Cytotoxicity of sesquiterpene alkaloids from Nuphar plants toward sensitive and drug-resistant cell lines

Fukaya, M., Nakamura, S., Hegazy, M. E. F., Sugimoto, Y., Hayashi, N., Nakashima, S., Yoshikawa, M., Efferth, T. & Matsuda, H., 2018 Dec 13, In : Food & function. 9, 12, p. 6279-6286 8 p.

Research output: Contribution to journalArticle

Nuphar
Sesquiterpenes
Alkaloids
sesquiterpenoids
cytotoxicity

Dearomative Oxidative Rearrangement of [3]Cyclo-1,8-carbazolylene

Yasui, M., Ohtsu, H., Kawano, M., Hanaya, K., Sugai, T. & Higashibayashi, S., 2018 Jan 1, In : Chemistry Letters. 47, 11, p. 1357-1359 3 p.

Research output: Contribution to journalArticle

Derivatives
X ray analysis
Ultraviolet spectroscopy
Absorption spectroscopy
Discrete Fourier transforms
7 Citations (Scopus)

Design of a transdermal formulation containing raloxifene nanoparticles for osteoporosis treatment

Nagai, N., Ogata, F., Otake, H., Nakazawa, Y. & Kawasaki, N., 2018 Jan 1, In : International Journal of Nanomedicine. 13, p. 5215-5229 15 p.

Research output: Contribution to journalArticle

Nanoparticles
Osteoporosis
Menthol
Rats
Skin

Design of functional thermoresponsive polymer brushes and their application to bioseparation

Nagase, K., Okano, T. & Kanazawa, H., 2018 Mar 1, In : Kobunshi Ronbunshu. 75, 2, p. 143-154 12 p.

Research output: Contribution to journalArticle

Functional polymers
Brushes
polymer
Proteins
Polymers
1 Citation (Scopus)
Colistin
Pharmacokinetics
Rats
High Pressure Liquid Chromatography
Plasmas
1 Citation (Scopus)

Development of nanocarriers functionalized with stimuli-responsive polymer for controlled cellular uptake

Yamanouchi, T., Katsuyama, N., Hiruta, Y., Ayano, E. & Kanazawa, H., 2018 Mar 1, In : Kobunshi Ronbunshu. 75, 2, p. 116-127 12 p.

Research output: Contribution to journalArticle

medicine
Medicine
Polymers
polymer
drug
2 Citations (Scopus)

Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells

Murakami, Y., Sugiyama, K., Ebinuma, H., Nakamoto, N., Ojiro, K., Cho, H., Taniki, N., Saito, Y., Teratani, T., Koda, Y., Suzuki, T., Saito, K., Fukasawa, M., Ikeda, M., Kato, N., Kanai, T. & Saito, H., 2018 Jun 25, In : BMC Cancer. 18, 1, 680.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Liver Neoplasms
Hepacivirus
Hepatocytes
Virus Diseases
2 Citations (Scopus)

Early generated B-1–derived B cells have the capacity to progress to become mantle cell lymphoma–like neoplasia in aged mice

Hayakawa, K., Formica, A. M., Nakao, Y., Ichikawa, D., Shinton, S. A., Brill-Dashoff, J., Smith, M. R., Morse, H. C. & Hardy, R. R., 2018 Jul 15, In : Journal of Immunology. 201, 2, p. 804-813 10 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Neoplasms
Lymph Nodes
Intestines
Mantle-Cell Lymphoma
4 Citations (Scopus)

Effectiveness of influenza vaccination for children in Japan: Four-year observational study using a large-scale claims database

Shibata, N., Kimura, S., Hoshino, T., Takeuchi, M. & Urushihara, H., 2018 Jan 1, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

observational studies
influenza
Human Influenza
Observational Studies
Japan
4 Citations (Scopus)

Effect of hesperetin derivatives on the development of selenite-induced cataracts in rats

Nakazawa, Y., Pauze, M., Fukuyama, K., Nagai, N., Tago, M., Sugai, T. & Tamura, H., 2018 Jul 1, In : Molecular Medicine Reports. 18, 1, p. 1043-1050 8 p.

Research output: Contribution to journalArticle

Selenious Acid
Cataract
Rats
Derivatives
Ascorbic Acid

Effect of serotonin transporter genotype on self-reported efficacy and activity changes of brain prefrontal area in response to placebo

Isawa, M., Tashiro, R., Naruse, C., Yamaguchi, Y., Itoh, H., Nishimura, T., Tomi, M., Shimada, H., Saito, H., Mochizuki, M. & Nakashima, E., 2018 Jan 1, In : Pharmazie. 73, 1, p. 35-41 7 p.

Research output: Contribution to journalArticle

Serotonin Plasma Membrane Transport Proteins
Genotype
Placebos
Brain
Caffeine
1 Citation (Scopus)
1-Octanol
theaflavins
octanol
Monophenol Monooxygenase
Catechin
2 Citations (Scopus)
Functional Food
randomized clinical trials
Japan
learning
Randomized Controlled Trials
2 Citations (Scopus)

Extraction and standardization of patient complaints from electronic medication histories for pharmacovigilance: Natural language processing analysis in Japanese

Usui, M., Aramaki, E., Iwao, T., Wakamiya, S., Sakamoto, T. & Mochizuki, M., 2018 Sep 1, In : Journal of Medical Internet Research. 20, 9, e11021.

Research output: Contribution to journalArticle

Natural Language Processing
Pharmacovigilance
International Classification of Diseases
Delivery of Health Care
Pharmacies

Facile determination of sphingolipids under alkali condition using metal-free column by LC-MS/MS

Siddabasave, S. G., Ikeda, K. & Arita, M., 2018 May 9, (Accepted/In press) In : Analytical and Bioanalytical Chemistry. p. 1-11 11 p.

Research output: Contribution to journalArticle

Sphingolipids
Alkalies
Metals
Specific Pathogen-Free Organisms
Liquid chromatography
1 Citation (Scopus)

Factors predicting the therapeutic response to infliximab during maintenance therapy in Japanese patients with Crohn's disease

Matsuoka, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Kanai, T., Mochizuki, M. & Hashiguchi, M., 2018 Oct 1, In : PLoS One. 13, 10, e0204632.

Research output: Contribution to journalArticle

Crohn disease
Crohn Disease
tumor necrosis factors
therapeutics
Tumor Necrosis Factor-alpha
1 Citation (Scopus)

Factors predicting the therapeutic response to methotrexate in Japanese patients with rheumatoid arthritis: A hospital-based cohort study

Hakamata, J., Kaneko, Y., Shimizu, M., Yamaoka, K., Maruyama, J., Takeuchi, T., Mochizuki, M. & Hashiguchi, M., 2018 Jan 1, In : Biological and Pharmaceutical Bulletin. 41, 9, p. 1414-1422 9 p.

Research output: Contribution to journalArticle

Methotrexate
Rheumatoid Arthritis
Cohort Studies
Therapeutics
Genotype
4 Citations (Scopus)

Formal synthesis of englerin A utilizing regio- and diastereoselective [4+3] cycloaddition

Hagihara, S., Hanaya, K., Sugai, T. & Shoji, M., 2018 Feb 1, In : Journal of Antibiotics. 71, 2, p. 257-262 6 p.

Research output: Contribution to journalArticle

Guaiane Sesquiterpenes
Phyllanthus
Kidney Neoplasms
Cycloaddition Reaction
Ether
2 Citations (Scopus)

Formal total synthesis of (-)-hamigeran B from a chemo-enzymatically prepared building block with quaternary chiral center

Kuwata, K., Fujita, R., Hanaya, K., Higashibayashi, S. & Sugai, T., 2018 Jan 1, (Accepted/In press) In : Tetrahedron.

Research output: Contribution to journalArticle

Hydrogenation
Alcohol Oxidoreductases
Stereochemistry
Cyclization
Catalysis
3 Citations (Scopus)

Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR

Maruyama, T., Imai, S., Kusakizako, T., Hattori, M., Ishitani, R., Nureki, O., Ito, K., Maturana, A. D., Shimada, I. & Osawa, M., 2018 Apr 3, In : eLife. 7, e31596.

Research output: Contribution to journalArticle

Binding Sites
Nuclear magnetic resonance
Ions
Homeostasis
Divalent Cations
2 Citations (Scopus)

Gene expression of A6-like subgroup of ATP-binding cassette transporters in mouse brain parenchyma and microvessels

Tachikawa, M., Toki, H., Watanabe, M., Tomi, M., Hosoya, K. I. & Terasaki, T., 2018 Mar 8, (Accepted/In press) In : Anatomical Science International. p. 1-8 8 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Microvessels
Gene Expression
Brain
Endothelial Cells
2 Citations (Scopus)

Heat shock protein 90 inhibitors overcome the resistance to Fms-like tyrosine kinase 3 inhibitors in acute myeloid leukemia

Katayama, K., Noguchi, K. & Sugimoto, Y., 2018 Sep 1, In : Oncotarget. 9, 76, p. 34240-34258 19 p.

Research output: Contribution to journalArticle

fms-Like Tyrosine Kinase 3
HSP90 Heat-Shock Proteins
Acute Myeloid Leukemia
4'-N-benzoylstaurosporine
Protein-Tyrosine Kinases
12 Citations (Scopus)

Hydroxytyrosol butyrate inhibits 6-OHDA-induced apoptosis through activation of the Nrf2/HO-1 axis in SH-SY5Y cells

Tago, M., Sakata, T., Fujiwara, S., Sakakura, A., Sugai, T., Tago, K. & Tamura, H., 2018 Sep 5, In : European Journal of Pharmacology. 834, p. 246-256 11 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Heme Oxygenase-1
Butyrates
Oxidopamine
Apoptosis
2 Citations (Scopus)

Hypotaurine is a substrate of GABA transporter family members GAT2/Slc6a13 and TAUT/Slc6a6

Nishimura, T., Higuchi, K., Yoshida, Y., Sugita-Fujisawa, Y., Kojima, K., Sugimoto, M., Santo, M., Tomi, M. & Nakashima, E., 2018 Jan 1, In : Biological and Pharmaceutical Bulletin. 41, 10, p. 1523-1529 7 p.

Research output: Contribution to journalArticle

Acids
Cysteamine
Taurine
Oxidative Stress
hypotaurine
1 Citation (Scopus)

Identification of mesothelioma-specific sialylated epitope recognized with monoclonal antibody SKM9-2 in a mucin-like membrane protein HEG1

Matsuura, R., Kaji, H., Tomioka, A., Sato, T., Narimatsu, H., Moriwaki, Y., Misawa, H., Imai, K. & Tsuji, S., 2018 Dec 1, In : Scientific Reports. 8, 1, 14251.

Research output: Contribution to journalArticle

Mesothelioma
Mucins
Epitopes
Membrane Proteins
Monoclonal Antibodies
5 Citations (Scopus)

Identification of Protein Targets of 12/15-Lipoxygenase-Derived Lipid Electrophiles in Mouse Peritoneal Macrophages Using Omega-Alkynyl Fatty Acid

Isobe, Y., Kawashima, Y., Ishihara, T., Watanabe, K., Ohara, O. & Arita, M., 2018 Apr 20, In : ACS Chemical Biology. 13, 4, p. 887-893 7 p.

Research output: Contribution to journalArticle

Macrophages
Peritoneal Macrophages
Fatty Acids
Lipids
Proteins
1 Citation (Scopus)

IL-10 promoter transactivation by the viral K-RTA protein involves the host-cell transcription factors, specificity proteins 1 and 3

Miyazawa, M., Noguchi, K., Kujirai, M., Katayama, K., Yamagoe, S. & Sugimoto, Y., 2018 Jan 12, In : Journal of Biological Chemistry. 293, 2, p. 662-676 15 p.

Research output: Contribution to journalArticle

Sp3 Transcription Factor
Sp1 Transcription Factor
Human Herpesvirus 8
Transcription
Interleukin-10
9 Citations (Scopus)

Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system

Saito, Y., Nakaoka, T., Muramatsu, T., Ojima, H., Sukeda, A., Sugiyama, Y., Uchida, R., Furukawa, R., Kitahara, A., Sato, T., Kanai, Y. & Saito, H., 2018 Dec 1, In : Scientific Reports. 8, 1, 2821.

Research output: Contribution to journalArticle

Organoids
Cholangiocarcinoma
Hepatocytes
Intrahepatic Bile Ducts
Cytochrome P-450 CYP3A
7 Citations (Scopus)

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes

Komine, O., Yamashita, H., Fujimori-Tonou, N., Koike, M., Jin, S., Moriwaki, Y., Endo, F., Watanabe, S., Uematsu, S., Akira, S., Uchiyama, Y., Takahashi, R., Misawa, H. & Yamanaka, K., 2018 Mar 22, (Accepted/In press) In : Cell Death and Differentiation. p. 1-17 17 p.

Research output: Contribution to journalArticle

Deficiency Diseases
Amyotrophic Lateral Sclerosis
Astrocytes
Disease Progression
Myeloid Differentiation Factor 88
4 Citations (Scopus)

Intestinal epithelial cell-specific deletion of α-mannosidase II ameliorates experimental colitis

Suzuki, K., Yamada, T., Yamazaki, K., Hirota, M., Ishihara, N., Sakamoto, M., Takahashi, D., Iijima, H. & Hase, K., 2018 Jan 1, In : Cell Structure and Function. 43, 1, p. 25-39 15 p.

Research output: Contribution to journalArticle

Colitis
Inflammatory Bowel Diseases
Epithelial Cells
Glycosylation
Chemokines