Faculty of Pharmacy

Research Output 1975 2020

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Article
2018
4 Citations (Scopus)
Quercetin
Molecules
fisetin
naringin

Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation

Ohe, T., Umezawa, R., Kitagawara, Y., Yasuda, D., Takahashi, K., Nakamura, S., Abe, A., Sekine, S., Ito, K., Okunushi, K., Morio, H., Furihata, T., Anzai, N. & Mashino, T., 2018 Jan 1, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Benzbromarone
Uricosuric Agents
Chemical activation
Derivatives
Uric Acid
4 Citations (Scopus)

Synthesis of oroxylin A starting from naturally abundant baicalin

Fujita, R., Hanaya, K., Higashibayashi, S. & Sugai, T., 2018 Jan 1, In : Heterocycles. 97, 2, p. 1165-1174 10 p.

Research output: Contribution to journalArticle

Ether
Sterilizers
Acetylation
Methylation
Glucuronides
2 Citations (Scopus)
Hydrolysis
Sterilizers
2,4-Dichlorophenoxyacetic Acid
Steam
Pressure
8 Citations (Scopus)

Taxodione induces apoptosis in BCR-ABL-positive cells through ROS generation

Uchihara, Y., Tago, K., Taguchi, H., Narukawa, Y., Kiuchi, F., Tamura, H. & Tago, M., 2018 Aug 1, In : Biochemical Pharmacology. 154, p. 357-372 16 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Cells
Apoptosis
Leukemia
K562 Cells
8 Citations (Scopus)

The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques

Nagatake, T., Shiogama, Y., Inoue, A., Kikuta, J., Honda, T., Tiwari, P., Kishi, T., Yanagisawa, A., Isobe, Y., Matsumoto, N., Shimojou, M., Morimoto, S., Suzuki, H., Hirata, S. I., Steneberg, P., Edlund, H., Aoki, J., Arita, M., Kiyono, H., Yasutomi, Y. & 3 others, Ishii, M., Kabashima, K. & Kunisawa, J., 2018 Jan 1, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Contact Dermatitis
Macaca
G-Protein-Coupled Receptors
Neutrophils
Acids
1 Citation (Scopus)
Amlodipine
Charcoal
Drug Interactions
Eating
Pharmaceutical Preparations
3 Citations (Scopus)

Therapeutic effect of vitamin D3-containing nanostructured lipid carriers on inflammatory bowel disease

Zai, K., Hirota, M., Yamada, T., Ishihara, N., Mori, T., Kishimura, A., Suzuki, K., Hase, K. & Katayama, Y., 2018 Sep 28, In : Journal of Controlled Release. 286, p. 94-102 9 p.

Research output: Contribution to journalArticle

Cholecalciferol
Therapeutic Uses
Inflammatory Bowel Diseases
Lipids
Dextran Sulfate

Three new 5,6,7,8-tetrahydroxy-5,6,7,8-tetrahydrochromone derivatives enantiomeric to agarotetrol from agarwood

Sugiyama, T., Narukawa, Y., Shibata, S., Masui, R. & Kiuchi, F., 2018 Mar 10, (Accepted/In press) In : Journal of Natural Medicines. p. 1-8 8 p.

Research output: Contribution to journalArticle

Thymelaeaceae
Type 3 Cyclic Nucleotide Phosphodiesterases
Chromones
Derivatives
Stereochemistry
2 Citations (Scopus)

Thromboxane A2 facilitates IL-17A production from Vγ4+ γδ T cells and promotes psoriatic dermatitis in mice

Ueharaguchi, Y., Honda, T., Kusuba, N., Hanakawa, S., Adachi, A., Sawada, Y., Otsuka, A., Kitoh, A., Dainichi, T., Egawa, G., Nakashima, C., Nakajima, S., Murata, T., Ono, S., Arita, M., Narumiya, S., Miyachi, Y. & Kabashima, K., 2018 Jan 1, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Thromboxane A2
Interleukin-17
Dermatitis
T-Lymphocytes
3 Citations (Scopus)

Transport of Pregabalin Via L-Type Amino Acid Transporter 1 (SLC7A5) in Human Brain Capillary Endothelial Cell Line

Takahashi, Y., Nishimura, T., Higuchi, K., Noguchi, S., Tega, Y., Kurosawa, T., Deguchi, Y. & Tomi, M., 2018 Oct 29, In : Pharmaceutical Research. 35, 12, 1 p.

Research output: Contribution to journalArticle

Large Neutral Amino Acid-Transporter 1
Amino Acid Transport Systems
Endothelial cells
Brain
Endothelial Cells
7 Citations (Scopus)

Triazasumanene: An isoelectronic heteroanalogue of sumanene

Tan, Q., Kaewmati, P., Higashibayashi, S., Kawano, M., Yakiyama, Y. & Sakurai, H., 2018 Jan 1, In : Bulletin of the Chemical Society of Japan. 91, 4, p. 531-537 7 p.

Research output: Contribution to journalArticle

Crystals
Chirality
Optical band gaps
Molecular orbitals
Electronic structure
10 Citations (Scopus)

Tris(2-hydroxyphenyl)triazasumanene: Bowl-shaped excited-state intramolecular proton transfer (ESIPT) fluorophore coupled with aggregation-induced enhanced emission (AIEE)

Kaewmati, P., Yakiyama, Y., Ohtsu, H., Kawano, M., Haesuwannakij, S., Higashibayashi, S. & Sakurai, H., 2018 Jan 1, In : Materials Chemistry Frontiers. 2, 3, p. 514-519 6 p.

Research output: Contribution to journalArticle

Proton transfer
Fluorophores
Excited states
Agglomeration
Single crystals

医師・看護師・薬剤師の連携による地域医療の質の向上―忘れがちな障害,爪白癬の治療を通して―

Translated title of the contribution: Improvement in the quality of regional medical care through the cooperation of physicians, nurses, and pharmacists: Cooperative treatment of undiagnosed onychomycosisImazu, Y., Yoneta, Y., Uchida, E., Yamaura, K. & Suzuki, J., 2018 Jan 1, In : Yakugaku Zasshi. 138, 5, p. 601-605 5 p.

Research output: Contribution to journalArticle

Open Access
Onychomycosis
Quality Improvement
Pharmacists
Nurses
Physicians

粘膜面におけるバリア機能と免疫恒常性の維持に果たす M 細胞の役割

Translated title of the contribution: Intestinal M cells contribute to the maintenance of mucosal barrier functions and immune homeostasisIshihara, N., Kobayashi, N. & Hase, K., 2018 Jan 1, In : Japanese Journal of Allergology. 67, 3, p. 171-178 8 p.

Research output: Contribution to journalArticle

Homeostasis
Maintenance
2017
6 Citations (Scopus)

12-OH-17,18-Epoxyeicosatetraenoic acid alleviates eosinophilic airway inflammation in murine lungs

Mochimaru, T., Fukunaga, K., Miyata, J., Matsusaka, M., Masaki, K., Kabata, H., Ueda, S., Suzuki, Y., Goto, T., Urabe, D., Inoue, M., Isobe, Y., Arita, M. & Betsuyaku, T., 2017, (Accepted/In press) In : Allergy: European Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Eicosapentaenoic Acid
Inflammation
Lung
Acids
Eosinophils
4 Citations (Scopus)

Administration of antioxidant compounds affects the lens chaperone activity and prevents the onset of cataracts

Nakazawa, Y., Nagai, N., Ishimori, N., Oguchi, J. & Tamura, H., 2017 Nov 1, In : Biomedicine and Pharmacotherapy. 95, p. 137-143 7 p.

Research output: Contribution to journalArticle

Cataract
Lenses
Antioxidants
Crystallins
Coffee
7 Citations (Scopus)

Alpha-tocopherol attenuates the anti-tumor activity of crizotinib against cells transformed by NPM-ALK

Uchihara, Y., Ueda, F., Tago, K., Nakazawa, Y., Ohe, T., Mashino, T., Yokota, S., Kasahara, T., Tamura, H. & Tago, M., 2017 Aug 1, In : PLoS One. 12, 8, e0183003.

Research output: Contribution to journalArticle

alpha-Tocopherol
lymphoma
alpha-tocopherol
Tumors
phosphotransferases (kinases)
10 Citations (Scopus)

A misfolded dimer of Cu/Zn-superoxide dismutase leading to pathological oligomerization in amyotrophic lateral sclerosis

Anzai, I., Tokuda, E., Mukaiyama, A., Akiyama, S., Endo, F., Yamanaka, K., Misawa, H. & Furukawa, Y., 2017 Mar 1, In : Protein Science. 26, 3, p. 484-496 13 p.

Research output: Contribution to journalArticle

Oligomerization
Amyotrophic Lateral Sclerosis
Disulfides
Dimers
Oligomers
2 Citations (Scopus)

A mouse model reveals that Mfsd2a is critical for unfolded protein response upon exposure to tunicamycin

Moritake, H., Obara, M., Saito, Y., Kashimada, A., Takagi, M., Tago, M., Fukuyama, T., Yoshioka, M., Inoue, A., Komatsu, H., Nishitoh, H., Kataoka, H. & Nunoi, H., 2017 Apr 1, In : Human Cell. 30, 2, p. 88-97 10 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Tunicamycin
Thapsigargin
Docosahexaenoic Acids
Hypersensitivity
terbinafine
Nortriptyline
Amitriptyline
Drug Interactions
Tricyclic Antidepressive Agents
6 Citations (Scopus)

A nanoparticle-based ophthalmic formulation of dexamethasone enhances corneal permeability of the drug and prolongs its corneal residence time

Nagai, N., Nakazawa, Y., Ito, Y., Kanai, K., Okamoto, N. & Shimomura, Y., 2017, In : Biological and Pharmaceutical Bulletin. 40, 7, p. 1055-1062 8 p.

Research output: Contribution to journalArticle

Nanoparticles
Dexamethasone
Permeability
Pharmaceutical Preparations
Parabens
3 Citations (Scopus)

An empirical study of the prescription pattern of drugs for hematological malignancies in Japan from 2010-2014

Shibata, S., Wayama, Y., Tsuyuki, A., Matsushita, M., Chiba, K., Matsuki, E., Okamoto, S. & Suzuki, T., 2017, In : Biological and Pharmaceutical Bulletin. 40, 6, p. 894-901 8 p.

Research output: Contribution to journalArticle

Prescription Drugs
Hematologic Neoplasms
Japan
Pharmaceutical Preparations
Pharmaceutical Databases
1 Citation (Scopus)

A novel phenylphthalimide derivative, pegylated TC11, improves pharmacokinetic properties and induces apoptosis of high-risk myeloma cells via G2/M cell-cycle arrest

Aida, S., Hozumi, M., Ichikawa, D., Iida, K., Yonemura, Y., Tabata, N., Yamada, T., Matsushita, M., Sugai, T., Yanagawa, H. & Hattori, Y., 2017, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

G2 Phase Cell Cycle Checkpoints
Pharmacokinetics
Multiple Myeloma
Polyethylene glycols
Cells
20 Citations (Scopus)

APC mutations as a potential biomarker for sensitivity to tankyrase inhibitors in colorectal cancer

Tanaka, N., Mashima, T., Mizutani, A., Sato, A., Aoyama, A., Gong, B., Yoshida, H., Muramatsu, Y., Nakata, K., Matsuura, M., Katayama, R., Nagayama, S., Fujita, N., Sugimoto, Y. & Seimiya, H., 2017 Apr 1, In : Molecular Cancer Therapeutics. 16, 4, p. 752-762 11 p.

Research output: Contribution to journalArticle

Tankyrases
Catenins
Adenomatous Polyposis Coli
Colorectal Neoplasms
Biomarkers
20 Citations (Scopus)

ARIH2 ubiquitinates NLRP3 and negatively regulates NLRP3 inflammasome activation in macrophages

Kawashima, A., Karasawa, T., Tago, K., Kimura, H., Kamata, R., Usui-Kawanishi, F., Watanabe, S., Ohta, S., Tago, M., Yanagisawa, K., Kasahara, T., Suzuki, K. & Takahashi, M., 2017 Nov 15, In : Journal of Immunology. 199, 10, p. 3614-3622 9 p.

Research output: Contribution to journalArticle

Inflammasomes
Macrophage Activation
Ubiquitination
Clustered Regularly Interspaced Short Palindromic Repeats
Caspase 1
16 Citations (Scopus)

Attenuation of CD4+CD25+ Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug

Kunisada, Y., Eikawa, S., Tomonobu, N., Domae, S., Uehara, T., Hori, S., Furusawa, Y., Hase, K., Sasaki, A. & Udono, H., 2017, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Tumor Microenvironment
T-cells
Metformin
Regulatory T-Lymphocytes
Medical problems
12 Citations (Scopus)

Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways

Aikawa, S., Kano, K., Inoue, A., Wang, J., Saigusa, D., Nagamatsu, T., Hirota, Y., Fujii, T., Tsuchiya, S., Taketomi, Y., Sugimoto, Y., Murakami, M., Arita, M., Kurano, M., Ikeda, H., Yatomi, Y., Chun, J. & Aoki, J., 2017, (Accepted/In press) In : EMBO Journal.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Embryonic Structures
Epithelium
Up-Regulation
Placentation
3 Citations (Scopus)

Cellular Uptake of Levocetirizine by Organic Anion Transporter 4

Noguchi, S., Nishimura, T., Mukaida, S., Benet, L. Z., Nakashima, E. & Tomi, M., 2017 Feb 15, (Accepted/In press) In : Journal of Pharmaceutical Sciences.

Research output: Contribution to journalArticle

Organic Anion Transporters
Cetirizine
Tetracycline
Proximal Kidney Tubule
Dehydroepiandrosterone Sulfate
4 Citations (Scopus)
Terpenes
Lipases
carboxylates
hydrolysis
acetates
8 Citations (Scopus)

Cluster microRNAs miR-194 and miR-215 suppress the tumorigenicity of intestinal tumor organoids

Nakaoka, T., Saito, Y., Shimamoto, Y., Muramatsu, T., Kimura, M., Kanai, Y. & Saito, H., 2017 Apr 1, In : Cancer Science. 108, 4, p. 678-684 7 p.

Research output: Contribution to journalArticle

Organoids
Neoplasms
MicroRNAs
Neoplastic Stem Cells
Intestinal Mucosa
13 Citations (Scopus)

Coffee extract inhibits adipogenesis in 3T3-L1 preadipocyes by interrupting insulin signaling through the downregulation of IRS1

Maki, C., Tago, M., Aoyagi, R., Ueda, F., Kimura, M., Kobata, K., Tago, K. & Tamura, H., 2017 Mar 1, In : PLoS One. 12, 3, e0173264.

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Adipogenesis
Coffee
insulin
Down-Regulation
5 Citations (Scopus)

Coffee reduces KRAS expression in Caco-2 human colon carcinoma cells via regulation of miRNAs

Nakayama, T., Tago, M. & Tamura, H., 2017, In : Oncology Letters. 14, 1, p. 1109-1114 6 p.

Research output: Contribution to journalArticle

Coffee
MicroRNAs
Colon
Carcinoma
Colonic Neoplasms
5 Citations (Scopus)

Co-instillation of nano-solid magnesium hydroxide enhances corneal permeability of dissolved timolol

Nagai, N., Ogata, F., Otake, H., Kawasaki, N., Nakazawa, Y., Kanai, K., Okamoto, N. & Shimomura, Y., 2017 Dec 1, In : Experimental Eye Research. 165, p. 118-124 7 p.

Research output: Contribution to journalArticle

Magnesium Hydroxide
Timolol
Permeability
Nanoparticles
Particle Size

Co-localization of microsomal prostaglandin E synthase-1 with cyclooxygenase-1 in layer II of murine placental syncytiotrophoblasts

Inagaki, M., Nishimura, T., Akanuma, S. I., Nakanishi, T., Tachikawa, M., Tamai, I., Hosoya, K. I., Nakashima, E. & Tomi, M., 2017 May 1, In : Placenta. 53, p. 174-182 9 p.

Research output: Contribution to journalArticle

Cyclooxygenase 1
Trophoblasts
Prostaglandins E
Placental Circulation
Dinoprostone
17 Citations (Scopus)

Commensal Lactobacillus Controls Immune Tolerance during Acute Liver Injury in Mice

Nakamoto, N., Amiya, T., Aoki, R., Taniki, N., Koda, Y., Miyamoto, K., Teratani, T., Suzuki, T., Chiba, S., Cho, H., Hayashi, A., Yamaguchi, A., Shiba, S., Miyake, R., Katayama, T., Suda, W., Mikami, Y., Kamada, N., Ebinuma, H., Saito, H. & 2 others, Hattori, M. & Kanai, T., 2017 Oct 31, In : Cell Reports. 21, 5, p. 1215-1226 12 p.

Research output: Contribution to journalArticle

Immune Tolerance
Lactobacillus
Liver
Wounds and Injuries
Dendritic Cells
12 Citations (Scopus)

Comprehensive analyses of oxidized phospholipids using a measured MS/MS spectra library

Aoyagi, R., Ikeda, K., Isobe, Y. & Arita, M., 2017, In : Journal of Lipid Research. 58, 11, p. 2229-2237 9 p.

Research output: Contribution to journalArticle

Libraries
Phospholipids
Arteriosclerosis
Macrophages
Peritoneal Macrophages
16 Citations (Scopus)

Comprehensive identification of sphingolipid species by in silico retention time and tandem mass spectral library

Tsugawa, H., Ikeda, K., Tanaka, W., Senoo, Y., Arita, M. & Arita, M., 2017 Mar 15, In : Journal of Cheminformatics. 9, 1, 19.

Research output: Contribution to journalArticle

Sphingolipids
Ceramides
Tissue
computer programs
mice

Construction of 2,6,9,11-tetraoxatricyclo[6.2.1.03,8]undecane containing 4-keto-D-glucose skeleton

Fujitani, B., Hanaya, K., Higashibayashi, S., Shoji, M. & Sugai, T., 2017 Dec 21, In : Tetrahedron. 73, 51, p. 7217-7222 6 p.

Research output: Contribution to journalArticle

Spironolactone
Stereochemistry
Skeleton
Scaffolds
undecane
5 Citations (Scopus)

Contributions of system A subtypes to α-methylaminoisobutyric acid uptake by placental microvillous membranes of human and rat

Takahashi, Y., Nishimura, T., Maruyama, T., Tomi, M. & Nakashima, E., 2017 Feb 4, (Accepted/In press) In : Amino Acids. p. 1-9 9 p.

Research output: Contribution to journalArticle

Rats
Betaine
Membranes
Acids
Arginine
2 Citations (Scopus)

CXorf48 is a potential therapeutic target for achieving treatment-free remission in CML patients

Matsushita, M., Ozawa, K., Suzuki, T., Nakamura, M., Nakano, N., Kanchi, S., Ichikawa, D., Matsuki, E., Sakurai, M., Karigane, D., Kasahara, H., Tsukamoto, N., Shimizu, T., Mori, T., Nakajima, H., Okamoto, S., Kawakami, Y. & Hattori, Y., 2017 Sep 1, In : Blood Cancer Journal. 7, 9, e601.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Stem Cells
Therapeutics
T-Lymphocytes
2 Citations (Scopus)

Data on the effect of hypomyelinating leukodystrophy 6 (HLD6)-associated mutations on the TUBB4A properties

Miyamoto, Y., Torii, T., Kawahara, K., Hasegawa, N., Tanoue, A., Seki, Y., Morimoto, T., Tago, M., Tamura, H., Homma, K., Yamamoto, M. & Yamauchi, J., 2017 Apr 1, In : Data in Brief. 11, p. 284-289 6 p.

Research output: Contribution to journalArticle

Disease
cause
4 Citations (Scopus)
Silicon Dioxide
Nanoparticles
Polymers
Silica
silicon dioxide
3 Citations (Scopus)

Detection of bacterial DNA by in situ hybridization in patients with decompensated liver cirrhosis

Usui, S., Ebinuma, H., Cho, H., Nakamoto, N., Yamagishi, Y., Saito, H. & Kanai, T., 2017 Oct 17, In : BMC Gastroenterology. 17, 1

Research output: Contribution to journalArticle

Bacterial DNA
Liver Cirrhosis
In Situ Hybridization
Peritonitis
Bacteria
7 Citations (Scopus)

Determination of polychlorinated biphenyls in marine fish obtained from tsunami-stricken areas of Japan

Uekusa, Y., Takatsuki, S., Tsutsumi, T., Akiyama, H., Matsuda, R., Teshima, R., Hachisuka, A. & Watanabe, T., 2017 Apr 1, In : PLoS One. 12, 4, e0174961.

Research output: Contribution to journalArticle

Tsunamis
tsunamis
Polychlorinated Biphenyls
polychlorinated biphenyls
marine fish
Pharmacy Students
Japan
Students
Diagnostic Self Evaluation
Pharmacists

Development of a new scholastic program for medication counseling practice in preclinical training, constructed for junior students by senior students based on their experiences of on-site practice

Suzuki, S., Aono, I., Imai, N., Kuwabara, A., Kenda, Y., Matsumoto, M., Yoshida, A., Watanabe, A., Takagi, A., Kobayashi, N., Saeki, H., Ohtani, H., Nakamur, T. & Kizud, J., 2017, In : Yakugaku Zasshi. 137, 11, p. 1391-1408 18 p.

Research output: Contribution to journalArticle

Counseling
Students
Pharmacy Education
Anxiety
Communication
12 Citations (Scopus)

Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor

Yasuda, D., Yuasa, A., Obata, R., Nakajima, M., Takahashi, K., Ohe, T., Ichimura, Y., Komatsu, M., Yamamoto, M., Imamura, R., Kojima, H., Okabe, T., Nagano, T. & Mashino, T., 2017 Nov 15, In : Bioorganic and Medicinal Chemistry Letters. 27, 22, p. 5006-5009 4 p.

Research output: Contribution to journalArticle

Indoles
Proteins
Hydroxamic Acids
Lead compounds
Derivatives
3 Citations (Scopus)

Dissociation of blood-brain barrier disruption and disease manifestation in an aquaporin-4-deficient mouse model of amyotrophic lateral sclerosis

Watanabe-Matsumoto, S., Moriwaki, Y., Okuda, T., Ohara, S., Yamanaka, K., Abe, Y., Yasui, M. & Misawa, H., 2017 Jan 1, (Accepted/In press) In : Neuroscience Research.

Research output: Contribution to journalArticle

Aquaporin 4
Amyotrophic Lateral Sclerosis
Blood-Brain Barrier
Motor Neuron Disease
Gliosis
2 Citations (Scopus)

Dosing optimization of meropenem based on a pharmacokinetic analysis in patients receiving hemodiafiltration and an in vitro model

Yokoyama, Y., Nishino, K., Matsumoto, K., Inomoto, Y., Matsuda, K., Nakamura, R. N., Yasuno, N. & Kizu, J., 2017, (Accepted/In press) In : Journal of Infection and Chemotherapy.

Research output: Contribution to journalArticle

meropenem
Hemodiafiltration
Pharmacokinetics
In Vitro Techniques