Faculty of Pharmacy

Research Output 1975 2020

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2017
15 Citations (Scopus)

Enhanced cellular uptake and gene silencing activity of siRNA using temperature-responsive polymer-modified liposome

Wang, J., Ayano, E., Maitani, Y. & Kanazawa, H., 2017 May 15, In : International Journal of Pharmaceutics. 523, 1, p. 217-228 12 p.

Research output: Contribution to journalArticle

Gene Silencing
Liposomes
Small Interfering RNA
Polymers
Temperature
7 Citations (Scopus)

Factorial analysis of hepatitis b virus reactivation-induced hepatitis b using jader

Hara, A., Matsumoto, K., Yokoyama, Y. & Kizu, J., 2017, In : Biological and Pharmaceutical Bulletin. 40, 6, p. 782-788 7 p.

Research output: Contribution to journalArticle

Hepatitis Viruses
Hepatitis B
Hepatitis
Prednisolone
Rheumatoid Arthritis
8 Citations (Scopus)

Formation and spreading of TDP-43 aggregates in cultured neuronal and glial cells demonstrated by time-lapse imaging

Ishii, T., Kawakami, E., Endo, K., Misawa, H. & Watabe, K., 2017 Jun 1, In : PLoS One. 12, 6, e0179375.

Research output: Contribution to journalArticle

Time-Lapse Imaging
DNA-binding proteins
DNA-Binding Proteins
neuroglia
cell aggregates
3 Citations (Scopus)

Fractional laser-assisted percutaneous drug delivery via temperature-responsive liposomes

Fujimoto, T., Ito, M., Ito, S. & Kanazawa, H., 2017 Feb 22, (Accepted/In press) In : Journal of Biomaterials Science, Polymer Edition. p. 1-11 11 p.

Research output: Contribution to journalArticle

Liposomes
Drug delivery
Lasers
Temperature
Pharmaceutical Preparations
8 Citations (Scopus)

Free cholesterol accumulation in liver sinusoidal endothelial cells exacerbates acetaminophen hepatotoxicity via TLR9 signaling

Teratani, T., Tomita, K., Suzuki, T., Furuhashi, H., Irie, R., Hida, S., Okada, Y., Kurihara, C., Ebinuma, H., Nakamoto, N., Saito, H., Hibi, T., Miura, S., Hokari, R. & Kanai, T., 2017, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

Toll-Like Receptor 9
Acetaminophen
Endothelial Cells
Cholesterol
Liver
2 Citations (Scopus)

Functional effects of AKT3 on aurora kinase inhibitorinduced aneuploidy

Noguchi, K., Hongama, K., Hariki, S., Nonomiya, Y., Katayama, K. & Sugimoto, Y., 2017 Feb 3, In : Journal of Biological Chemistry. 292, 5, p. 1910-1924 15 p.

Research output: Contribution to journalArticle

Aurora Kinases
Aneuploidy
HCT116 Cells
Anaphase
Phosphorylation
4 Citations (Scopus)

Guidelines for therapeutic drug monitoring of cardiovascular drugs clinical use of blood drug concentration monitoring (Jcs 2015) ― digest version ―

Japanese Circulation Society & Japanese Society of Therapeutic Drug Monitoring Joint Working Group, 2017, In : Circulation Journal. 81, 4, p. 581-612 32 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice

Yang, J. Y., Lee, Y. S., Kim, Y., Lee, S. H., Ryu, S., Fukuda, S., Hase, K., Yang, C. S., Lim, H. S., Kim, M. S., Kim, H. M., Ahn, S. H., Kwon, B. E., Ko, H. J. & Kweon, M. N., 2017 Jan 1, In : Mucosal Immunology. 10, 1, p. 104-116 13 p.

Research output: Contribution to journalArticle

Bacteroides
Insulin Resistance
Obesity
Bacteria
Adipose Tissue
13 Citations (Scopus)

Gut microbiota-mediated generation of saturated fatty acids elicits inflammation in the liver in murine high-fat diet-induced steatohepatitis

Yamada, S., Kamada, N., Amiya, T., Nakamoto, N., Nakaoka, T., Kimura, M., Saito, Y., Ejima, C., Kanai, T. & Saito, H., 2017 Nov 29, In : BMC Gastroenterology. 17, 1, 136.

Research output: Contribution to journalArticle

High Fat Diet
Fatty Liver
Fatty Acids
Inflammation
Liver
62 Citations (Scopus)

Gut microbiota promotes obesity-associated liver cancer through pge2-mediated suppression of antitumor immunity

Loo, T. M., Kamachi, F., Watanabe, Y., Yoshimoto, S., Kanda, H., Arai, Y., Nakajima-Takagi, Y., Iwama, A., Koga, T., Sugimoto, Y., Ozawa, T., Nakamura, M., Kumagai, M., Watashi, K., Taketo, M. M., Aoki, T., Narumiya, S., Oshima, M., Arita, M., Hara, E. & 1 others, Ohtani, N., 2017 May 1, In : Cancer Discovery. 7, 5, p. 522-538 17 p.

Research output: Contribution to journalArticle

Liver Neoplasms
Hepatocellular Carcinoma
Immunity
Obesity
Dinoprostone
12 Citations (Scopus)

HEG1 is a novel mucin-like membrane protein that serves as a diagnostic and therapeutic target for malignant mesothelioma

Tsuji, S., Washimi, K., Kageyama, T., Yamashita, M., Yoshihara, M., Matsuura, R., Yokose, T., Kameda, Y., Hayashi, H., Morohoshi, T., Tsuura, Y., Yusa, T., Sato, T., Togayachi, A., Narimatsu, H., Nagasaki, T., Nakamoto, K., Moriwaki, Y., Misawa, H., Hiroshima, K. & 2 others, Miyagi, Y. & Imai, K., 2017 Mar 31, In : Scientific Reports. 7, 45768.

Research output: Contribution to journalArticle

Mucins
Membrane Proteins
Therapeutics
Mesothelioma
Gene Silencing
2 Citations (Scopus)

Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation

Yotsumoto, S., Muroi, Y., Chiba, T., Ohmura, R., Yoneyama, M., Magarisawa, M., Dodo, K., Terayama, N., Sodeoka, M., Aoyagi, R., Arita, M., Arakawa, S., Shimizu, S. & Tanaka, M., 2017 Dec 1, In : Scientific Reports. 7, 1, 16026.

Research output: Contribution to journalArticle

Phospholipid Ethers
Sulfasalazine
Sulfapyridine
Lipids
Sulfones
21 Citations (Scopus)

IL-22BP dictates characteristics of Peyer's patch follicleassociated epithelium for antigen uptake

Jinnohara, T., Kanaya, T., Hase, K., Sakakibara, S., Kato, T., Tachibana, N., Sasaki, T., Hashimoto, Y., Sato, T., Watarai, H., Kunisawa, J., Shibata, N., Williams, I. R., Kiyono, H. & Ohno, H., 2017 Jun 1, In : Journal of Experimental Medicine. 214, 6, p. 1607-1618 12 p.

Research output: Contribution to journalArticle

Peyer's Patches
Carrier Proteins
Epithelium
Antigens
interleukin-22
11 Citations (Scopus)

Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis

Tokuda, E., Anzai, I., Nomura, T., Toichi, K., Watanabe, M., Ohara, S., Watanabe, S., Yamanaka, K., Morisaki, Y., Misawa, H. & Furukawa, Y., 2017 Jan 5, In : Molecular Neurodegeneration. 12, 1, 2.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Disulfides
Antibodies
Motor Neurons
Transgenic Mice
2 Citations (Scopus)

Impact of generic entry to off-patent branded medicines in Japanese pharmaceutical market

Fukumoto, D. & Suzuki, T., 2017 Sep 1, In : Journal of Generic Medicines. 13, 3, p. 114-122 9 p.

Research output: Contribution to journalArticle

Nonprescription Drugs
Pharmaceutical Preparations
Off-Label Use
Police
Health Expenditures

Improvement of dissolution rate and stability in a pirenoxine ophthalmic suspension by the bead mill methods

Ueno, A., Yamaoka, S., Ito, Y., Kotake, T., Nakazawa, Y. & Nagai, N., 2017, In : Yakugaku Zasshi. 137, 5, p. 635-641 7 p.

Research output: Contribution to journalArticle

Suspensions
Ophthalmic Solutions
Particle Size
pirenoxine
Methylcellulose
1 Citation (Scopus)

Inactivation kinetics and residual activity of CYP3A4 after treatment with erythromycin

Ishikawa, Y., Akiyoshi, T., Imaoka, A. & Ohtani, H., 2017 Oct 1, In : Biopharmaceutics and Drug Disposition. 38, 7, p. 420-425 6 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Erythromycin
Area Under Curve
Nifedipine
Testosterone
3 Citations (Scopus)

Intracellular localization and delivery of plasmid DNA by biodegradable microsphere-mediated femtosecond laser optoporation

Ishii, A., Hiruta, Y., Heinemann, D., Heisterkamp, A., Kanazawa, H. & Terakawa, M., 2017, (Accepted/In press) In : Journal of Biophotonics.

Research output: Contribution to journalArticle

plasmids
Liposomes
Ultrashort pulses
Microspheres
delivery
17 Citations (Scopus)

Local Release of VEGF Using Fiber Mats Enables Effective Transplantation of Layered Cardiomyocyte Sheets

Nagase, K., Nagumo, Y., Kim, M., Kim, H. J., Kyung, H. W., Chung, H. J., Sekine, H., Shimizu, T., Kanazawa, H., Okano, T., Lee, S. J. & Yamato, M., 2017, (Accepted/In press) In : Macromolecular Bioscience.

Research output: Contribution to journalArticle

Cardiac Myocytes
Vascular Endothelial Growth Factor A
Transplantation
Fibers
Cell Transplantation
13 Citations (Scopus)

Micro/nano-imprinted substrates grafted with a thermoresponsive polymer for thermally modulated cell separation

Nagase, K., Shukuwa, R., Onuma, T., Yamato, M., Takeda, N. & Okano, T., 2017, In : Journal of Materials Chemistry B. 5, 30, p. 5924-5930 7 p.

Research output: Contribution to journalArticle

Cell Separation
Polymers
Cell adhesion
Substrates
Atom transfer radical polymerization
1 Citation (Scopus)

Model for studying anti- allergic drugs for allergic conjunctivitis in animals

Nakazawa, Y., Oka, M. & Takehana, M., 2017 Jan 1, In : Open Medicine (Poland). 12, 1, p. 231-238 8 p.

Research output: Contribution to journalArticle

Allergic Conjunctivitis
Anti-Allergic Agents
Ovalbumin
Tears
Eosinophils
7 Citations (Scopus)

mTOR signaling mediates resistance to tankyrase inhibitors in Wnt-driven colorectal cancer

Mashima, T., Taneda, Y., Jang, M. K., Mizutani, A., Muramatsu, Y., Yoshida, H., Sato, A., Tanaka, N., Sugimoto, Y. & Seimiya, H., 2017, In : Oncotarget. 8, 29, p. 47902-47915 14 p.

Research output: Contribution to journalArticle

Tankyrases
Catenins
Colorectal Neoplasms
Cell Line
Poly(ADP-ribose) Polymerases
4 Citations (Scopus)

Myelinating cocultures of rodent stem cell line-derived neurons and immortalized Schwann cells

Ishii, T., Kawakami, E., Endo, K., Misawa, H. & Watabe, K., 2017, (Accepted/In press) In : Neuropathology.

Research output: Contribution to journalArticle

Schwann Cells
Coculture Techniques
Rodentia
Stem Cells
Neurons
5 Citations (Scopus)

NALT M cells are important for immune induction for the common mucosal immune system

Date, Y., Ebisawa, M., Fukuda, S., Shima, H., Obata, Y., Takahashi, D., Kato, T., Hanazato, M., Nakato, G., Williams, I. R., Hase, K. & Ohno, H., 2017 Oct 1, In : International Immunology. 29, 10, p. 471-478 8 p.

Research output: Contribution to journalArticle

Nasopharynx
Lymphoid Tissue
Immune System
Attenuated Vaccines
Nose

National survey of therapeutic drug monitoring (TDM) of antimicrobial drugs: Comparison with the TDM guidelines for antimicrobial drugs

Matsumoto, K., Isoda, R., Kuroda, Y., Yokoyama, Y. & Kizu, J., 2017 Mar 1, In : Japanese Journal of Chemotherapy. 65, 2, p. 175-182 8 p.

Research output: Contribution to journalArticle

Drug Monitoring
Guidelines
Infection Control
Pharmaceutical Preparations
Pharmacists
55 Citations (Scopus)

Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens

Kim, Y., Sakamoto, K., Seo, S. U., Pickard, J. M., Gillilland, M. G., Pudlo, N. A., Hoostal, M., Li, X., Wang, T. D., Feehley, T., Stefka, A. T., Schmidt, T. M., Martens, E. C., Fukuda, S., Inohara, N., Nagler, C. R. & Núñez, G., 2017 Apr 21, In : Science. 356, 6335, p. 315-319 5 p.

Research output: Contribution to journalArticle

Clostridium
Microbiota
Infection
Immune System
Pathology
1 Citation (Scopus)

NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome

Hayakawa, K., Formica, A. M., Zhou, Y., Ichikawa, D., Asano, M., Li, Y. S., Shinton, S. A., Brill-Dashoff, J., Núñez, G. & Hardy, R. R., 2017, In : Journal of Experimental Medicine. 214, 10, p. 3067-3083 17 p.

Research output: Contribution to journalArticle

B-Cell Antigen Receptors
B-Lymphocytes
Ligands
Immunoglobulin Light Chains
Autoantigens
3 Citations (Scopus)

Non-Planar [n]Cyclo-1,8-carbazolylenes (n=3,4,6) and [3]Cyclo-1,8-carbazolylenyl B, P, PO, SiPh Complexes

Yamamoto, K., Pandit, P. & Higashibayashi, S., 2017 Oct 9, In : Chemistry - A European Journal. 23, 56, p. 14011-14016 6 p.

Research output: Contribution to journalArticle

Oligomerization
Polysilicon
Acidity
Electronic structure
Boron

On the existence of a darling-kac set for the renormalized rauzy map

Inoue, K. & Nakada, H., 2017 Jan 1, In : Tokyo Journal of Mathematics. 34, 2, p. 289-302 14 p.

Research output: Contribution to journalArticle

Ergodicity
Imply
23 Citations (Scopus)

On-treatment decrease of NKG2D correlates to early emergence of clinically evident hepatocellular carcinoma after interferon-free therapy for chronic hepatitis C

Cho, H., Nakamoto, N., Taniki, N., Ojiro, K., Amiya, T., Makita, Y., Murata, H., Yamaguchi, A., Shiba, S., Miyake, R., Katayama, T., Yoshida, A., Ikura, A., Takeda, K., Ebinuma, H., Saito, H. & Kanai, T., 2017 Jun 1, In : PLoS One. 12, 6, e0179096.

Research output: Contribution to journalArticle

chronic hepatitis C
antiviral agents
Chronic Hepatitis C
interferons
hepatoma
6 Citations (Scopus)

Ophthalmic formulation containing nilvadipine nanoparticles prevents retinal dysfunction in rats injected with streptozotocin

Deguchi, S., Otake, H., Nakazawa, Y., Hiramatsu, N., Yamamoto, N. & Nagai, N., 2017 Dec 15, In : International Journal of Molecular Sciences. 18, 12, 2720.

Research output: Contribution to journalArticle

nilvadipine
Streptozocin
Nanoparticles
rats
Rats
Generic Drugs
Japan
Cytostatic Agents
Pharmaceutical Preparations
Neoplasms
4 Citations (Scopus)

Phosphorylated CIS suppresses the Epo or JAK2 V617F mutant-triggered cell proliferation through binding to EpoR

Tago, M., Moriwaki, T., Ueda, F., Tamura, H., Kasahara, T. & Tago, K., 2017 Feb 1, In : Cellular Signalling. 31, p. 41-57 17 p.

Research output: Contribution to journalArticle

STAT5 Transcription Factor
Cell Proliferation
Neoplasms
Suppressor of Cytokine Signaling Proteins
Cytokines
Lipase
Alcohols
Acetylation
Enantiomers
Acetates
7 Citations (Scopus)

Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy

Ikutani, M., Tsuneyama, K., Kawaguchi, M., Fukuoka, J., Kudo, F., Nakae, S., Arita, M., Nagai, Y., Takaki, S. & Takatsu, K., 2017 Apr 6, In : JCI insight. 2, 7, p. e90721

Research output: Contribution to journalArticle

Open Access
Interleukin-5
Eosinophils
Hypertrophy
Lung
Pulmonary Artery
1 Citation (Scopus)

Propofol-fentanyl interaction in Beagles - Apnea, response to mechanical ventilation, endotracheal tube, and tetanic stimulation

Iizuka, T., Masui, K., Miyabe-Nishiwaki, T., Kanazawa, H. & Nishimura, R., 2017 Dec 1, In : Research in Veterinary Science. 115, p. 34-42 9 p.

Research output: Contribution to journalArticle

apnea
fentanyl
Fentanyl
Propofol
Apnea
12 Citations (Scopus)

Reversible conformational changes in the parallel type G-quadruplex structure inside a thermoresponsive hydrogel

Hasuike, E., Akimoto, A. M., Kuroda, R., Matsukawa, K., Hiruta, Y., Kanazawa, H. & Yoshida, R., 2017, In : Chemical Communications. 53, 21, p. 3142-3144 3 p.

Research output: Contribution to journalArticle

Hydrogels
Hydrogel
Spectrophotometers
Gels
Temperature
3 Citations (Scopus)

Risk factors for abnormal hepatic enzyme elevation by methotrexate treatment in patients with rheumatoid arthritis: A hospital based-cohort study

Hakamata, J., Hashiguchi, M., Kaneko, Y., Yamaoka, K., Shimizu, M., Maruyama, J., Takeuchi, T. & Mochizuki, M., 2017 Dec 27, (Accepted/In press) In : Modern Rheumatology. p. 1-10 10 p.

Research output: Contribution to journalArticle

Methotrexate
Rheumatoid Arthritis
Cohort Studies
Liver
Enzymes
5 Citations (Scopus)

Roasting Enhances the Anti-Cataract Effect of Coffee Beans: Ameliorating Selenite-Induced Cataracts in Rats

Ishimori, N., Oguchi, J., Nakazawa, Y., Kobata, K., Tago, M. & Tamura, H., 2017 Jan 28, (Accepted/In press) In : Current Eye Research. p. 1-7 7 p.

Research output: Contribution to journalArticle

Selenious Acid
Coffee
Cataract
Caffeine
Antioxidants
2 Citations (Scopus)

Sex Differences in the Blood Concentration of Tacrolimus in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients with CYP3A5*3/*3

Ito, A., Okada, Y., Hashita, T., Aomori, T., Hiromura, K., Nojima, Y., Nakamura, T., Araki, T. & Yamamoto, K., 2017 Mar 21, (Accepted/In press) In : Biochemical Genetics. p. 1-10 10 p.

Research output: Contribution to journalArticle

tacrolimus
Cytochrome P-450 CYP3A
lupus erythematosus
rheumatoid arthritis
Tacrolimus
9 Citations (Scopus)

Short-step syntheses of naturally occurring polyoxygenated aromatics based on site-selective transformation

Yamashita, Y., Biard, A., Hanaya, K., Shoji, M. & Sugai, T., 2017, In : Bioscience, Biotechnology and Biochemistry. 81, 7, p. 1279-1284 6 p.

Research output: Contribution to journalArticle

Molecules
chrysin
polydatin
wogonin
astringin

Significant decreases in blood propofol concentrations during adrenalectomy for phaeochromocytoma

Watanabe, T., Hiraoka, H., Araki, T., Nagano, D., Aomori, T., Nakamura, T., Yamamoto, K. & Baba, H., 2017, (Accepted/In press) In : British Journal of Clinical Pharmacology.

Research output: Contribution to journalArticle

Adrenalectomy
Pheochromocytoma
Propofol
Arterial Pressure
Neoplasms
1 Citation (Scopus)

ST2 gene products critically contribute to cellular transformation caused by an oncogenic Ras mutant

Tago, K., Ohta, S., Kashiwada, M., Tago, M., Matsugi, J., Tominaga, S. I. & Yanagisawa, K., 2017, (Accepted/In press) In : Heliyon.

Research output: Contribution to journalArticle

Gene Expression
Genes
Fibroblasts
Cell Proliferation
Gene Knockdown Techniques
4 Citations (Scopus)

STAT3 and ERK pathways are involved in cell growth stimulation of the ST2/IL1RL1 promoter

Tago, K., Ohta, S., Tago, M., Aoki-Ohmura, C., Matsugi, J., Tominaga, S. I. & Yanagisawa, K., 2017 Feb 1, In : FEBS Open Bio. 7, 2, p. 293-302 10 p.

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Cell growth
Genes
Growth
Gene Expression
1 Citation (Scopus)

Suppression of infliximab antibody levels by azathioprine in patients with rheumatoid arthritis

Aomori, T., Tsuchiya, A., Suzuki, S., Jibiki, A., Otsuka, N., Ishioka, E., Kaneko, Y., Takeuchi, T. & Nakamura, T., 2017, In : Pharmazie. 72, 2, p. 95-97 3 p.

Research output: Contribution to journalArticle

Azathioprine
Rheumatoid Arthritis
Antibodies
Methotrexate
Serum
11 Citations (Scopus)
Scutellaria
Flavonoids
Anti-Inflammatory Agents
Dinoprostone
Messenger RNA
2 Citations (Scopus)

Synthesis and biological evaluation of the natural product komaroviquinone and related compounds aiming at a potential therapeutic lead compound for high-risk multiple myeloma

Suto, Y., Sato, M., Fujimori, K., Kitabatake, S., Okayama, M., Ichikawa, D., Matsushita, M., Yamagiwa, N., Iwasaki, G., Kiuchi, F. & Hattori, Y., 2017 Oct 1, In : Bioorganic and Medicinal Chemistry Letters. 27, 19, p. 4558-4563 6 p.

Research output: Contribution to journalArticle

Lead compounds
Biological Products
Multiple Myeloma
Pharmaceutical Preparations
Proteasome Inhibitors
4 Citations (Scopus)

Synthesis of a C70 Fragment Buckybowl C28H14 from a C60 fragment sumanene

Hishikawa, S., Okabe, Y., Tsuruoka, R., Higashibayashi, S., Ohtsu, H., Kawano, M., Yakiyama, Y. & Sakurai, H., 2017, In : Chemistry Letters. 46, 10, p. 1556-1559 4 p.

Research output: Contribution to journalArticle

Physical properties
sumanene
1 Citation (Scopus)

Synthesis of benzyl tetra-O-acetyl-α-L-glucopyranoside from benzyl 2,3-dideoxy-β-D-Erythro-hex-2-enopyranoside

Okazaki, H., Ueda, Y., Hanaya, K., Shoji, M. & Sugai, T., 2017, In : Heterocycles. 95, 2, p. 862-871 10 p.

Research output: Contribution to journalArticle

Glucose
Derivatives
Stereochemistry
Epoxidation
Skeleton
7 Citations (Scopus)

Synthesis of enantiomerically enriched drug precursors and an insect pheromone via reduction of ketones using commercially available carbonyl reductase screening kit "Chiralscreen® OH"

Nagai, T., Sakurai, S., Natori, N., Hataoka, M., Kinoshita, T., Inoue, H., Hanaya, K., Shoji, M. & Sugai, T., 2017 Jan 14, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

Alcohol Oxidoreductases
Rivastigmine
Pheromones
Prodrugs
Ketones