School of Pharmaceutical Sciences

Research Output

2020

Accumulation of major linezolid metabolites in patients with renal impairment

Souza, E., Crass, R. L., Felton, J., Hanaya, K. & Pai, M. P., 2020 May 1, In : Antimicrobial Agents and Chemotherapy. 64, 5, e00027-20.

Research output: Contribution to journalArticle

Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model

Abe, Y., Ikegawa, N., Yoshida, K., Muramatsu, K., Hattori, S., Kawai, K., Murakami, M., Tanaka, T., Goda, W., Goto, M., Yamamoto, T., Hashimoto, T., Yamada, K., Shibata, T., Misawa, H., Mimura, M., Tanaka, K. F., Miyakawa, T., Iwatsubo, T., Hata, J. I. & 2 others, Niikura, T. & Yasui, M., 2020 May 12, In : Acta Neuropathologica Communications. 8, 1, 67.

Research output: Contribution to journalArticle

Open Access

Commensal-bacteria-derived butyrate promotes the t-cell-independent iga response in the colon

Isobe, J., Maeda, S., Obata, Y., Iizuka, K., Nakamura, Y., Fujimura, Y., Kimizuka, T., Hattori, K., Kim, Y. G., Morita, T., Kimura, I., Offermanns, S., Adachi, T., Nakao, A., Kiyono, H., Takahashi, D. & Hase, K., 2020 Apr 1, In : International immunology. 32, 4, p. 243-258 16 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Comprehensive semisyntheses of catathelasmols C, D, and E from D-glutamic acid, utilizing lipase-catalyzed site-selective reactions on intermediates

Hashiba, R., Hashimoto, R., Nishiguchi, M., Kobayashi, T., Hanaya, K., Higashibayashi, S. & Sugai, T., 2020 Jul 2, In : Bioscience, Biotechnology and Biochemistry. 84, 7, p. 1339-1344 6 p.

Research output: Contribution to journalArticle

Development of a sensitive LC–MS/MS method for quantification of linezolid and its primary metabolites in human serum

Souza, E., Felton, J., Crass, R. L., Hanaya, K. & Pai, M. P., 2020 Jan 30, In : Journal of Pharmaceutical and Biomedical Analysis. 178, 112968.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Open Access

Inhibitors of the protein–protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line

Yasuda, D., Ohe, T., Takahashi, K., Imamura, R., Kojima, H., Okabe, T., Ichimura, Y., Komatsu, M., Yamamoto, M., Nagano, T. & Mashino, T., 2020 Jan 1, (Accepted/In press) In : Free Radical Research.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice

Kimura, I., Miyamoto, J., Ohue-Kitano, R., Watanabe, K., Yamada, T., Onuki, M., Aoki, R., Isobe, Y., Kashihara, D., Inoue, D., Inaba, A., Takamura, Y., Taira, S., Kumaki, S., Watanabe, M., Ito, M., Nakagawa, F., Irie, J., Kakuta, H., Shinohara, M. & 6 others, Iwatsuki, K., Tsujimoto, G., Ohno, H., Arita, M., Itoh, H. & Hase, K., 2020 Feb 28, In : Science. 367, 6481, eaaw8429.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity

Nakamura, Y., Mimuro, H., Kunisawa, J., Furusawa, Y., Takahashi, D., Fujimura, Y., Kaisho, T., Kiyono, H. & Hase, K., 2020 Jul 1, In : Mucosal Immunology. 13, 4, p. 679-690 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity

Kimura, S., Nakamura, Y., Kobayashi, N., Shiroguchi, K., Kawakami, E., Mutoh, M., Takahashi-Iwanaga, H., Yamada, T., Hisamoto, M., Nakamura, M., Udagawa, N., Sato, S., Kaisho, T., Iwanaga, T. & Hase, K., 2020 Dec 1, In : Nature communications. 11, 1, 234.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Oxidative misfolding of Cu/Zn-superoxide dismutase triggered by non-canonical intramolecular disulfide formation

Anzai, I., Tokuda, E., Handa, S., Misawa, H., Akiyama, S. & Furukawa, Y., 2020 Feb 1, In : Free Radical Biology and Medicine. 147, p. 187-199 13 p.

Research output: Contribution to journalArticle

Simultaneous analysis of multiple oligonucleotides by temperature-responsive chromatography using a poly(N-isopropylacrylamide)-based stationary phase

Maekawa, Y., Yamazaki, K., Ihara, M., Nagase, K. & Kanazawa, H., 2020 Jan 1, (Accepted/In press) In : Analytical and bioanalytical chemistry. 412, 22, p. 5341-5351 11 p.

Research output: Contribution to journalArticle

Open Access
Open Access

Synthesis and evaluation of nevirapine analogs to study the metabolic activation of nevirapine

Tateishi, Y., Ohe, T., Yasuda, D., Takahashi, K., Nakamura, S., Kazuki, Y. & Mashino, T., 2020 Apr, In : Drug Metabolism And Pharmacokinetics. 35, 2, p. 238-243 6 p.

Research output: Contribution to journalArticle

Thermoresponsive anionic copolymer brush-grafted surfaces for cell separation

Nagase, K., Uchikawa, N., Hirotani, T., Akimoto, A. M. & Kanazawa, H., 2020 Jan 1, In : Colloids and Surfaces B: Biointerfaces. 185, 110565.

Research output: Contribution to journalArticle

2019

Adsorption-Desorption Control of Fibronectin in Real Time at the Liquid/Polymer Interface on a Quartz Crystal Microbalance by Thermoresponsivity

Li, J., Kaku, T., Tokura, Y., Matsukawa, K., Homma, K., Nishimoto, T., Hiruta, Y., Akimoto, A. M., Nagase, K., Kanazawa, H. & Shiratori, S., 2019 Apr 8, In : Biomacromolecules. 20, 4, p. 1748-1755 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Airway M Cells arise in the lower airway due to RANKL signaling and reside in the bronchiolar epithelium associated with iBALT in murine models of respiratory disease

Kimura, S., Mutoh, M., Hisamoto, M., Saito, H., Takahashi, S., Asakura, T., Ishii, M., Nakamura, Y., Iida, J., Hase, K. & Iwanaga, T., 2019, In : Frontiers in Immunology. 10, JUN, 1323.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

A partial agonist for retinoid X receptor mitigates experimental colitis

Masayoshi, O., Masaki, W., Narumi, I., Koichiro, S., Kei, T., Masato, H., Takahiro, Y., Aiko, E., Osamu, S., Midori, N., Michiko, F., Makoto, M., Daisuke, T., Yukihiro, F., Hiroki, K. & Koji, H., 2019 Feb 19, In : International immunology. 31, 4, p. 251-262 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

CD44-targeting nanocarriers for cancer treatment

Yamanouchi, T. & Kanazawa, H., 2019 Jan 1, In : Drug Delivery System. 34, 1, p. 38-45 8 p.

Research output: Contribution to journalArticle

Open Access

Characteristic differences of cell sheets composed of mesenchymal stem cells with different tissue origins

Nakao, M., Inanaga, D., Nagase, K. & Kanazawa, H., 2019 Dec 1, In : Regenerative Therapy. 11, p. 34-40 7 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2 Citations (Scopus)

Crosslinked Poly(N-Isopropylacrylamide)-Based Microfibers as Cell Manipulation Materials with Prompt Cell Detachment

Konishi, T., Mizutani Akimoto, A., Nishimoto, T., Tokura, Y., Tenjimbayashi, M., Homma, K., Matsukawa, K., Kaku, T., Hiruta, Y., Nagase, K., Kanazawa, H. & Shiratori, S., 2019 Dec 1, In : Macromolecular Rapid Communications. 40, 23, 1900464.

Research output: Contribution to journalArticle

Design of VEGF releasing fiber mat for effective transplantation of cardiomyocyte sheets

Nagase, K. & Kanazawa, H., 2019 Jan 1, In : Drug Delivery System. 34, 3, p. 173-178 6 p.

Research output: Contribution to journalArticle

Open Access

Distinct roles of α7 nAChRs in antigen-presenting cells and CD4+ T cells in the regulation of T cell differentiation

Mashimo, M., Komori, M., Matsui, Y. Y., Murase, M. X., Fujii, T., Takeshima, S., Okuyama, H., Ono, S., Moriwaki, Y., Misawa, H. & Kawashima, K., 2019 Jan 1, In : Frontiers in Immunology. 10, MAY, 1102.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Editorial: Immunological Consequences of Antigen Sampling at Mucosal Surfaces

Mabbott, N. A. & Hase, K., 2019 Nov 26, In : Frontiers in Immunology. 10, 2773.

Research output: Contribution to journalEditorial

Open Access

Effect of polymer phase transition behavior on temperature-responsive polymer-modified liposomes for siRNA transfection

Nagase, K., Hasegawa, M., Ayano, E., Maitani, Y. & Kanazawa, H., 2019 Jan 2, In : International Journal of Molecular Sciences. 20, 2, 430.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses

Nagai, M., Noguchi, R., Takahashi, D., Morikawa, T., Koshida, K., Komiyama, S., Ishihara, N., Yamada, T., Kawamura, Y. I., Muroi, K., Hattori, K., Kobayashi, N., Fujimura, Y., Hirota, M., Matsumoto, R., Aoki, R., Tamura-Nakano, M., Sugiyama, M., Katakai, T., Sato, S. & 3 others, Takubo, K., Dohi, T. & Hase, K., 2019 Aug 22, In : Cell. 178, 5, p. 1072-1087.e14

Research output: Contribution to journalArticle

13 Citations (Scopus)

LAT1-Targeting Thermoresponsive Liposomes for Effective Cellular Uptake by Cancer Cells

Maekawa-Matsuura, M., Fujieda, K., Maekawa, Y., Nishimura, T., Nagase, K. & Kanazawa, H., 2019 Apr 8, In : ACS Omega. 4, 4, p. 6443-6451 9 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
1 Citation (Scopus)

Liposomes with temperature-responsive reversible surface properties

Nemoto, R., Fujieda, K., Hiruta, Y., Hishida, M., Ayano, E., Maitani, Y., Nagase, K. & Kanazawa, H., 2019 Apr 1, In : Colloids and Surfaces B: Biointerfaces. 176, p. 309-316 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Maintenance of Intestinal Epithelial Homeostasis by Zinc Transporters

Ohashi, W., Hara, T., Takagishi, T., Hase, K. & Fukada, T., 2019 Jan 1, In : Digestive Diseases and Sciences.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis

Nishida, K., Hasegawa, A., Yamasaki, S., Uchida, R., Ohashi, W., Kurashima, Y., Kunisawa, J., Kimura, S., Iwanaga, T., Watarai, H., Hase, K., Ogura, H., Nakayama, M., Kashiwakura, J. I., Okayama, Y., Kubo, M., Ohara, O., Kiyono, H., Koseki, H., Murakami, M. & 1 others, Hirano, T., 2019 Dec 1, In : Scientific reports. 9, 1, 10842.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Mixed polymer brush as a functional ligand of silica beads for temperature-modulated hydrophobic and electrostatic interactions

Nagase, K., Kitazawa, S., Yamada, S., Akimoto, A. M. & Kanazawa, H., 2019 Jan 1, (Accepted/In press) In : Analytica Chimica Acta.

Research output: Contribution to journalArticle

Mucin O-glycans facilitate symbiosynthesis to maintain gut immune homeostasis

Yamada, T., Hino, S., Iijima, H., Genda, T., Aoki, R., Nagata, R., Han, K. H., Hirota, M., Kinashi, Y., Oguchi, H., Suda, W., Furusawa, Y., Fujimura, Y., Kunisawa, J., Hattori, M., Fukushima, M., Morita, T. & Hase, K., 2019 Jan 1, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

MZB1 promotes the secretion of J-chain–containing dimeric IgA and is critical for the suppression of gut inflammation

Xiong, E., Li, Y., Min, Q., Cui, C., Liu, J., Hong, R., Lai, N., Wang, Y., Sun, J., Matsumoto, R., Takahashi, D., Hase, K., Shinkura, R., Tsubata, T. & Wang, J. Y., 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13480-13489 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

N-Acetyl cysteine prevents activities of STAT3 inhibitors, Stattic and BP-1-102 independently of its antioxidant properties

Uchihara, Y., Ohe, T., Mashino, T., Kidokoro, T., Tago, K., Tamura, H. & Funakoshi-Tago, M., 2019 Dec, In : Pharmacological Reports. 71, 6, p. 1067-1078 12 p.

Research output: Contribution to journalArticle

Nanodiscs for structural biology in a membranous environment

Yokogawa, M., Fukuda, M. & Osawa, M., 2019 Jan 1, In : Chemical and Pharmaceutical Bulletin. 67, 4, p. 321-326 6 p.

Research output: Contribution to journalReview article

Open Access
2 Citations (Scopus)

Phenotypic traits of mesenchymal stem cell sheets fabricated by temperature-responsive cell culture plate: Structural characteristics of MSC sheets

Nakao, M., Kim, K., Nagase, K., Grainger, D. W., Kanazawa, H. & Okano, T., 2019 Nov 28, In : Stem Cell Research and Therapy. 10, 1, 353.

Research output: Contribution to journalArticle

Open Access

Regulation of inflammatory response of macrophages and induction of regulatory T cells by using retinoic acid-loaded nanostructured lipid carrier

Zai, K., Ishihara, N., Oguchi, H., Hirota, M., Kishimura, A., Mori, T., Hase, K. & Katayama, Y., 2019 Jan 1, (Accepted/In press) In : Journal of Biomaterials Science, Polymer Edition.

Research output: Contribution to journalArticle

Site-selective synthesis of acacetin and genkwanin through lipase-catalyzed deacetylation of apigenin 5,7-diacetate and subsequent methylation

Fujita, R., Mandal, S., Hanaya, K., Shoji, M., Higashibayashi, S. & Sugai, T., 2019 Jan 1, In : Heterocycles. 99, 1, p. 638-648 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice

Kimura, S., Kobayashi, N., Nakamura, Y., Kanaya, T., Takahashi, D., Fujiki, R., Mutoh, M., Obata, Y., Iwanaga, T., Nakagawa, T., Kato, N., Sato, S., Kaisho, T., Ohno, H. & Hase, K., 2019 Apr 1, In : Journal of Experimental Medicine. 216, 4, p. 831-846 16 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel

Kano, H., Toyama, Y., Imai, S., Iwahashi, Y., Mase, Y., Yokogawa, M., Osawa, M. & Shimada, I., 2019 Dec 1, In : Nature communications. 10, 1, 2008.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Synthesis and antitumor activity of novel pyridinium fullerene derivatives

Yasuno, T., Ohe, T., Ikeda, H., Takahashi, K., Nakamura, S. & Mashino, T., 2019 Jan 1, In : International journal of nanomedicine. 14, p. 6325-6337 13 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
1 Citation (Scopus)
2 Citations (Scopus)
3 Citations (Scopus)