School of Pharmaceutical Sciences

Research Output 1976 2020

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2020

Thermoresponsive anionic copolymer brush-grafted surfaces for cell separation

Nagase, K., Uchikawa, N., Hirotani, T., Akimoto, A. M. & Kanazawa, H., 2020 Jan 1, In : Colloids and Surfaces B: Biointerfaces. 185, 110565.

Research output: Contribution to journalArticle

Cell Separation
brushes
Brushes
copolymers
Polymers
2019
4 Citations (Scopus)

Adsorption-Desorption Control of Fibronectin in Real Time at the Liquid/Polymer Interface on a Quartz Crystal Microbalance by Thermoresponsivity

Li, J., Kaku, T., Tokura, Y., Matsukawa, K., Homma, K., Nishimoto, T., Hiruta, Y., Akimoto, A. M., Nagase, K., Kanazawa, H. & Shiratori, S., 2019 Jan 1, In : Biomacromolecules.

Research output: Contribution to journalArticle

Quartz crystal microbalances
Fibronectins
Desorption
Polymers
Adsorption
1 Citation (Scopus)

Airway M Cells arise in the lower airway due to RANKL signaling and reside in the bronchiolar epithelium associated with iBALT in murine models of respiratory disease

Kimura, S., Mutoh, M., Hisamoto, M., Saito, H., Takahashi, S., Asakura, T., Ishii, M., Nakamura, Y., Iida, J., Hase, K. & Iwanaga, T., 2019 Jan 1, In : Frontiers in Immunology. 10, JUN, 1323.

Research output: Contribution to journalArticle

Open Access
Lymphoid Tissue
Bronchi
Epithelium
Respiratory System
Glycoproteins
2 Citations (Scopus)

A partial agonist for retinoid X receptor mitigates experimental colitis

Masayoshi, O., Masaki, W., Narumi, I., Koichiro, S., Kei, T., Masato, H., Takahiro, Y., Aiko, E., Osamu, S., Midori, N., Michiko, F., Makoto, M., Takahashi, D., Yukihiro, F., Hiroki, K. & Koji, H., 2019 Feb 19, In : International Immunology. 31, 4, p. 251-262 12 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Colitis
Cytoplasmic and Nuclear Receptors
Ulcerative Colitis
Peroxisome Proliferator-Activated Receptors

CD44-targeting nanocarriers for cancer treatment

Yamanouchi, T. & Kanazawa, H., 2019 Jan 1, In : Drug Delivery System. 34, 1, p. 38-45 8 p.

Research output: Contribution to journalArticle

Open Access
Hyaluronic Acid
Research
CD44 Antigens
Neoplasms
Neoplastic Stem Cells

Characteristic differences of cell sheets composed of mesenchymal stem cells with different tissue origins

Nakao, M., Inanaga, D., Nagase, K. & Kanazawa, H., 2019 Dec 1, In : Regenerative Therapy. 11, p. 34-40 7 p.

Research output: Contribution to journalArticle

Open Access
Stem cells
Mesenchymal Stromal Cells
Tissue
Cell culture
Cell Culture Techniques
2 Citations (Scopus)
Lipopolysaccharides
Nitric Oxide
Acylation
Hydroxylation
Butyrates

Crosslinked Poly(N-Isopropylacrylamide)-Based Microfibers as Cell Manipulation Materials with Prompt Cell Detachment

Konishi, T., Mizutani Akimoto, A., Nishimoto, T., Tokura, Y., Tenjimbayashi, M., Homma, K., Matsukawa, K., Kaku, T., Hiruta, Y., Nagase, K., Kanazawa, H. & Shiratori, S., 2019 Jan 1, (Accepted/In press) In : Macromolecular Rapid Communications. 1900464.

Research output: Contribution to journalArticle

Cell adhesion
Temperature
Intelligent materials
Fibers
Swelling
1 Citation (Scopus)

Distinct roles of α7 nAChRs in antigen-presenting cells and CD4+ T cells in the regulation of T cell differentiation

Mashimo, M., Komori, M., Matsui, Y. Y., Murase, M. X., Fujii, T., Takeshima, S., Okuyama, H., Ono, S., Moriwaki, Y., Misawa, H. & Kawashima, K., 2019 Jan 1, In : Frontiers in Immunology. 10, MAY, 1102.

Research output: Contribution to journalArticle

Open Access
Nicotinic Receptors
Antigen-Presenting Cells
Cell Differentiation
T-Lymphocytes
Ovalbumin
3 Citations (Scopus)

Effect of polymer phase transition behavior on temperature-responsive polymer-modified liposomes for siRNA transfection

Nagase, K., Hasegawa, M., Ayano, E., Maitani, Y. & Kanazawa, H., 2019 Jan 2, In : International Journal of Molecular Sciences. 20, 2, 430.

Research output: Contribution to journalArticle

Liposomes
Phase Transition
Small Interfering RNA
Transfection
Polymers
1 Citation (Scopus)
Open Access
Endocytosis
Indomethacin
Nanoparticles
Nystatin
Pharmaceutical Preparations
3 Citations (Scopus)

Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses

Nagai, M., Noguchi, R., Takahashi, D., Morikawa, T., Koshida, K., Komiyama, S., Ishihara, N., Yamada, T., Kawamura, Y. I., Muroi, K., Hattori, K., Kobayashi, N., Fujimura, Y., Hirota, M., Matsumoto, R., Aoki, R., Tamura-Nakano, M., Sugiyama, M., Katakai, T., Sato, S. & 3 others, Takubo, K., Dohi, T. & Hase, K., 2019 Aug 22, In : Cell. 178, 5, p. 1072-1087.e14

Research output: Contribution to journalArticle

Mucosal Immunity
Peyer's Patches
Fasting
B-Lymphocytes
Cells

LAT1-Targeting Thermoresponsive Liposomes for Effective Cellular Uptake by Cancer Cells

Maekawa-Matsuura, M., Fujieda, K., Maekawa, Y., Nishimura, T., Nagase, K. & Kanazawa, H., 2019 Apr 8, In : ACS Omega. 4, 4, p. 6443-6451 9 p.

Research output: Contribution to journalArticle

Open Access
Amino Acid Transport Systems
Liposomes
Amino acids
Cells
Tyrosine
Biological Products
Lipase
Hydrolysis
Esters
Candida antarctica lipase B
2 Citations (Scopus)

Liposomes with temperature-responsive reversible surface properties

Nemoto, R., Fujieda, K., Hiruta, Y., Hishida, M., Ayano, E., Maitani, Y., Nagase, K. & Kanazawa, H., 2019 Apr 1, In : Colloids and Surfaces B: Biointerfaces. 176, p. 309-316 8 p.

Research output: Contribution to journalArticle

Surface Properties
Liposomes
surface properties
Surface properties
Polymers

Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis

Nishida, K., Hasegawa, A., Yamasaki, S., Uchida, R., Ohashi, W., Kurashima, Y., Kunisawa, J., Kimura, S., Iwanaga, T., Watarai, H., Hase, K., Ogura, H., Nakayama, M., Kashiwakura, J. I., Okayama, Y., Kubo, M., Ohara, O., Kiyono, H., Koseki, H., Murakami, M. & 1 others, Hirano, T., 2019 Dec 1, In : Scientific reports. 9, 1, 10842.

Research output: Contribution to journalArticle

Open Access
Mast Cells
Wound Healing
Zinc
Interleukin-6
Skin

Mucin O-glycans facilitate symbiosynthesis to maintain gut immune homeostasis

Yamada, T., Hino, S., Iijima, H., Genda, T., Aoki, R., Nagata, R., Han, K. H., Hirota, M., Kinashi, Y., Oguchi, H., Suda, W., Furusawa, Y., Fujimura, Y., Kunisawa, J., Hattori, M., Fukushima, M., Morita, T. & Hase, K., 2019 Jan 1, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Open Access
Butyrates
Mucins
Polysaccharides
Homeostasis
Ulcerative Colitis
2 Citations (Scopus)

MZB1 promotes the secretion of J-chain–containing dimeric IgA and is critical for the suppression of gut inflammation

Xiong, E., Li, Y., Min, Q., Cui, C., Liu, J., Hong, R., Lai, N., Wang, Y., Sun, J., Matsumoto, R., Takahashi, D., Hase, K., Shinkura, R., Tsubata, T. & Wang, J. Y., 2019 Jan 1, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13480-13489 10 p.

Research output: Contribution to journalArticle

Immunoglobulin A
Inflammation
Colitis
Mucosal Immunity
Molecular Chaperones

N-Acetyl cysteine prevents activities of STAT3 inhibitors, Stattic and BP-1-102 independently of its antioxidant properties

Uchihara, Y., Ohe, T., Mashino, T., Kidokoro, T., Tago, K., Tamura, H. & Funakoshi-Tago, M., 2019 Dec, In : Pharmacological Reports. 71, 6, p. 1067-1078 12 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Cysteine
Antioxidants
Apoptosis
Reactive Oxygen Species

Nanodiscs for Structural Biology in a Membranous Environment

Yokogawa, M., Fukuda, M. & Osawa, M., 2019 Jan 1, In : Chemical & pharmaceutical bulletin. 67, 4, p. 321-326 6 p.

Research output: Contribution to journalArticle

Open Access
Membrane Proteins
Lipid bilayers
Lipid Bilayers
Micelles
Detergents

Regulation of inflammatory response of macrophages and induction of regulatory T cells by using retinoic acid-loaded nanostructured lipid carrier

Zai, K., Ishihara, N., Oguchi, H., Hirota, M., Kishimura, A., Mori, T., Hase, K. & Katayama, Y., 2019 Jan 1, (Accepted/In press) In : Journal of Biomaterials Science, Polymer Edition.

Research output: Contribution to journalArticle

T-cells
Macrophages
Regulatory T-Lymphocytes
Tretinoin
Lipids

Site-selective synthesis of acacetin and genkwanin through lipase-catalyzed deacetylation of apigenin 5,7-diacetate and subsequent methylation

Fujita, R., Mandal, S., Hanaya, K., Shoji, M., Higashibayashi, S. & Sugai, T., 2019 Jan 1, In : Heterocycles. 99, 1, p. 638-648 11 p.

Research output: Contribution to journalArticle

Apigenin
Methylation
Lipase
Ions
Porifera
2 Citations (Scopus)

Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice

Kimura, S., Kobayashi, N., Nakamura, Y., Kanaya, T., Takahashi, D., Fujiki, R., Mutoh, M., Obata, Y., Iwanaga, T., Nakagawa, T., Kato, N., Sato, S., Kaisho, T., Ohno, H. & Hase, K., 2019 Apr 1, In : The Journal of experimental medicine. 216, 4, p. 831-846 16 p.

Research output: Contribution to journalArticle

Open Access
Weaning
Immunoglobulin A
Mucosal Immunity
Antigens
Peyer's Patches

Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel

Kano, H., Toyama, Y., Imai, S., Iwahashi, Y., Mase, Y., Yokogawa, M., Osawa, M. & Shimada, I., 2019 Dec 1, In : Nature communications. 10, 1, 2008.

Research output: Contribution to journalArticle

Open Access
Inwardly Rectifying Potassium Channel
G-Protein-Coupled Receptors
GTP-Binding Proteins
Chemical activation
proteins

Synthesis and antitumor activity of novel pyridinium fullerene derivatives

Yasuno, T., Ohe, T., Ikeda, H., Takahashi, K., Nakamura, S. & Mashino, T., 2019 Jan 1, In : International journal of nanomedicine. 14, p. 6325-6337 13 p.

Research output: Contribution to journalArticle

Open Access
Fullerenes
Derivatives
Heterografts
Cell Line
Lead compounds
1 Citation (Scopus)
Cell Separation
Hydrogel
Hydrogels
Silicon Dioxide
beads
1 Citation (Scopus)
Polymers
polymer
Temperature
Silicon Dioxide
Sulfonic Acids
2018
3 Citations (Scopus)

A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis

Niino, T., Tago, K., Yasuda, D., Takahashi, K., Mashino, T., Tamura, H. & Tago, M., 2018 Sep 1, In : Biochemical Pharmacology. 155, p. 182-197 16 p.

Research output: Contribution to journalArticle

Derivatives
Acetylcysteine
Cysteine
Chemical activation
Antioxidants
5 Citations (Scopus)

A copper-deficient form of mutant Cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis

Tokuda, E., Nomura, T., Ohara, S., Watanabe, S., Yamanaka, K., Morisaki, Y., Misawa, H. & Furukawa, Y., 2018 Jun 1, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 6, p. 2119-2130 12 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Copper
Metals
Zinc
Spinal Cord

A major component of vitamin E, α-tocopherol inhibits the anti-tumor activity of crizotinib against cells transformed by EML4-ALK

Uchihara, Y., Kidokoro, T., Tago, K., Mashino, T., Tamura, H. & Tago, M., 2018 Apr 15, In : European Journal of Pharmacology. 825, p. 1-9 9 p.

Research output: Contribution to journalArticle

Tocopherols
Vitamin E
Neoplasms
Tocotrienols
Gene Fusion
4 Citations (Scopus)

Application of Hydrazine-Embedded Heterocyclic Compounds to High Voltage Rechargeable Lithium Organic Batteries

Shimizu, T., Yamamoto, K., Pandit, P., Yoshikawa, H. & Higashibayashi, S., 2018 Dec 1, In : Scientific Reports. 8, 1, 579.

Research output: Contribution to journalArticle

hydrazine
Heterocyclic Compounds
Lithium
Cathodes
Electrodes
3 Citations (Scopus)

Characterization of the multimeric structure of poly(A)-binding protein on a poly(A) tail

Sawazaki, R., Imai, S., Yokogawa, M., Hosoda, N., Hoshino, S. I., Mio, M., Mio, K., Shimada, I. & Osawa, M., 2018 Dec 1, In : Scientific Reports. 8, 1, 19659.

Research output: Contribution to journalArticle

Poly(A)-Binding Proteins
Carrier Proteins
Molecules
Messenger RNA
Transmission electron microscopy
1 Citation (Scopus)

Chemoenzymatic approaches to the synthesis of the (1S,2R)-isomer of benzyl 2-hydroxycyclohexanecarboxylate

Tsunekawa, R., Hanaya, K., Higashibayashi, S., Shoji, M. & Sugai, T., 2018 Jan 1, In : Molecular Catalysis. 444, p. 84-89 6 p.

Research output: Contribution to journalArticle

Isomers
isomers
synthesis
Stereoisomerism
enzymes

Dearomative Oxidative Rearrangement of [3]Cyclo-1,8-carbazolylene

Yasui, M., Ohtsu, H., Kawano, M., Hanaya, K., Sugai, T. & Higashibayashi, S., 2018 Jan 1, In : Chemistry Letters. 47, 11, p. 1357-1359 3 p.

Research output: Contribution to journalArticle

Derivatives
X ray analysis
Ultraviolet spectroscopy
Absorption spectroscopy
Discrete Fourier transforms
5 Citations (Scopus)

Design of a transdermal formulation containing raloxifene nanoparticles for osteoporosis treatment

Nagai, N., Ogata, F., Otake, H., Nakazawa, Y. & Kawasaki, N., 2018 Jan 1, In : International Journal of Nanomedicine. 13, p. 5215-5229 15 p.

Research output: Contribution to journalArticle

Nanoparticles
Osteoporosis
Menthol
Rats
Skin

Design of functional thermoresponsive polymer brushes and their application to bioseparation

Nagase, K., Okano, T. & Kanazawa, H., 2018 Mar 1, In : Kobunshi Ronbunshu. 75, 2, p. 143-154 12 p.

Research output: Contribution to journalArticle

Functional polymers
Brushes
polymer
Proteins
Polymers
1 Citation (Scopus)

Development of nanocarriers functionalized with stimuli-responsive polymer for controlled cellular uptake

Yamanouchi, T., Katsuyama, N., Hiruta, Y., Ayano, E. & Kanazawa, H., 2018 Mar 1, In : Kobunshi Ronbunshu. 75, 2, p. 116-127 12 p.

Research output: Contribution to journalArticle

medicine
Medicine
Polymers
polymer
drug
1 Citation (Scopus)

Effect of hesperetin derivatives on the development of selenite-induced cataracts in rats

Nakazawa, Y., Pauze, M., Fukuyama, K., Nagai, N., Tago, M., Sugai, T. & Tamura, H., 2018 Jul 1, In : Molecular Medicine Reports. 18, 1, p. 1043-1050 8 p.

Research output: Contribution to journalArticle

Selenious Acid
Cataract
Rats
Derivatives
Ascorbic Acid
4 Citations (Scopus)

Formal synthesis of englerin A utilizing regio- and diastereoselective [4+3] cycloaddition

Hagihara, S., Hanaya, K., Sugai, T. & Shoji, M., 2018 Feb 1, In : Journal of Antibiotics. 71, 2, p. 257-262 6 p.

Research output: Contribution to journalArticle

Guaiane Sesquiterpenes
Phyllanthus
Kidney Neoplasms
Cycloaddition Reaction
Ether
2 Citations (Scopus)

Formal total synthesis of (-)-hamigeran B from a chemo-enzymatically prepared building block with quaternary chiral center

Kuwata, K., Fujita, R., Hanaya, K., Higashibayashi, S. & Sugai, T., 2018 Jan 1, (Accepted/In press) In : Tetrahedron.

Research output: Contribution to journalArticle

Hydrogenation
Alcohol Oxidoreductases
Stereochemistry
Cyclization
Catalysis
2 Citations (Scopus)

Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR

Maruyama, T., Imai, S., Kusakizako, T., Hattori, M., Ishitani, R., Nureki, O., Ito, K., Maturana, A. D., Shimada, I. & Osawa, M., 2018 Apr 3, In : eLife. 7, e31596.

Research output: Contribution to journalArticle

Binding Sites
Nuclear magnetic resonance
Ions
Homeostasis
Divalent Cations
10 Citations (Scopus)

Hydroxytyrosol butyrate inhibits 6-OHDA-induced apoptosis through activation of the Nrf2/HO-1 axis in SH-SY5Y cells

Tago, M., Sakata, T., Fujiwara, S., Sakakura, A., Sugai, T., Tago, K. & Tamura, H., 2018 Sep 5, In : European Journal of Pharmacology. 834, p. 246-256 11 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Heme Oxygenase-1
Butyrates
Oxidopamine
Apoptosis

Identification of mesothelioma-specific sialylated epitope recognized with monoclonal antibody SKM9-2 in a mucin-like membrane protein HEG1

Matsuura, R., Kaji, H., Tomioka, A., Sato, T., Narimatsu, H., Moriwaki, Y., Misawa, H., Imai, K. & Tsuji, S., 2018 Dec 1, In : Scientific Reports. 8, 1, 14251.

Research output: Contribution to journalArticle

Mesothelioma
Mucins
Epitopes
Membrane Proteins
Monoclonal Antibodies
7 Citations (Scopus)

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes

Komine, O., Yamashita, H., Fujimori-Tonou, N., Koike, M., Jin, S., Moriwaki, Y., Endo, F., Watanabe, S., Uematsu, S., Akira, S., Uchiyama, Y., Takahashi, R., Misawa, H. & Yamanaka, K., 2018 Mar 22, (Accepted/In press) In : Cell Death and Differentiation. p. 1-17 17 p.

Research output: Contribution to journalArticle

Deficiency Diseases
Amyotrophic Lateral Sclerosis
Astrocytes
Disease Progression
Myeloid Differentiation Factor 88
4 Citations (Scopus)

Intestinal epithelial cell-specific deletion of α-mannosidase II ameliorates experimental colitis

Suzuki, K., Yamada, T., Yamazaki, K., Hirota, M., Ishihara, N., Sakamoto, M., Takahashi, D., Iijima, H. & Hase, K., 2018 Jan 1, In : Cell Structure and Function. 43, 1, p. 25-39 15 p.

Research output: Contribution to journalArticle

Colitis
Inflammatory Bowel Diseases
Epithelial Cells
Glycosylation
Chemokines
5 Citations (Scopus)

Involvement of endocytosis in the transdermal penetration mechanism of ketoprofen nanoparticles

Nagai, N., Ogata, F., Ishii, M., Fukuoka, Y., Otake, H., Nakazawa, Y. & Kawasaki, N., 2018 Jul 23, In : International Journal of Molecular Sciences. 19, 7, 2138.

Research output: Contribution to journalArticle

Ketoprofen
Endocytosis
Nanoparticles
Skin
penetration
4 Citations (Scopus)

LAT1-targeting thermoresponsive fluorescent polymer probes for cancer cell imaging

Matsuura, M., Ohshima, M., Hiruta, Y., Nishimura, T., Nagase, K. & Kanazawa, H., 2018 Jun 1, In : International Journal of Molecular Sciences. 19, 6, 1646.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
transporter
Fluorescent Dyes
amino acids
Amino acids
13 Citations (Scopus)

Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury

Okubo, K., Kurosawa, M., Kamiya, M., Urano, Y., Suzuki, A., Yamamoto, K., Hase, K., Honma, K., Sasaki, J., Miyauchi, H., Hoshino, T., Hayashi, M., Mayadas, T. N. & Hirahashi, J., 2018 Feb 1, In : Nature Medicine. 24, 2, p. 232-238 7 p.

Research output: Contribution to journalArticle

Rhabdomyolysis
Macrophages
Platelet Activation
Platelets
Acute Kidney Injury
2 Citations (Scopus)

Macrophages switch their phenotype by regulating maf expression during different phases of inflammation

Kikuchi, K., Iida, M., Ikeda, N., Moriyama, S., Hamada, M., Takahashi, S., Kitamura, H., Watanabe, T., Hasegawa, Y., Hase, K., Fukuhara, T., Sato, H., Kobayashi, E. H., Suzuki, T., Yamamoto, M., Tanaka, M. & Asano, K., 2018 Jul 15, In : Journal of Immunology. 201, 2, p. 635-651 17 p.

Research output: Contribution to journalArticle

Macrophages
Inflammation
Phenotype
MafF Transcription Factor
Down-Regulation
4 Citations (Scopus)

Mesenchylmal stem cell culture on poly(N-isopropylacrylamide) hydrogel with repeated thermo-stimulation

Akimoto, A. M., Niitsu, E. H., Nagase, K., Okano, T., Kanazawa, H. & Yoshida, R., 2018 Apr 21, In : International Journal of Molecular Sciences. 19, 4, 1253.

Research output: Contribution to journalArticle

stem cells
Hydrogel
Stem cells
stimulation
Cell culture