Research Output

2020

Association of glomerular DNA damage and DNA methylation with one-year eGFR decline in IgA nephropathy

Hayashi, K., Hishikawa, A., Hashiguchi, A., Azegami, T., Yoshimoto, N., Nakamichi, R., Tokuyama, H. & Itoh, H., 2020 Dec 1, In : Scientific reports. 10, 1, 237.

Research output: Contribution to journalArticle

Open Access
Open Access

Immunotherapy for obesity

Azegami, T. & Itoh, H., 2020 Jan 1, Therapeutic Vaccines as Novel Immunotherapy: Biological and Clinical Concepts. Springer Singapore, p. 33-44 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Infiltration of tumor-associated macrophages is involved in tumor programmed death-ligand 1 expression in early lung adenocarcinoma

Shima, T., Shimoda, M., Shigenobu, T., Ohtsuka, T., Nishimura, T., Emoto, K., Hayashi, Y., Iwasaki, T., Abe, T., Asamura, H. & Kanai, Y., 2020 Feb 1, In : Cancer science. 111, 2, p. 727-738 12 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Inositol 1,4,5-trisphosphate receptor 2 as a novel marker of vasculature to delineate processes of cardiopulmonary development

Ishizaki-Asami, R., Uchida, K., Tsuchihashi, T., Shibata, A., Kodo, K., Emoto, K., Mikoshiba, K., Takahashi, T. & Yamagishi, H., 2020 Feb 15, In : Developmental Biology. 458, 2, p. 237-245 9 p.

Research output: Contribution to journalArticle

Low birth weight trends: possible impacts on the prevalences of hypertension and chronic kidney disease

Kanda, T., Murai-Takeda, A., Kawabe, H. & Itoh, H., 2020 Jan 1, (Accepted/In press) In : Hypertension Research.

Research output: Contribution to journalReview article

Serum Krebs von den Lungen-6 level in the disease progression and treatment of Mycobacterium avium complex lung disease

Asakura, T., Kimizuka, Y., Nishimura, T., Suzuki, S., Namkoong, H., Masugi, Y., Sato, Y., Ishii, M. & Hasegawa, N., 2020, (Accepted/In press) In : Respirology.

Research output: Contribution to journalArticle

2019

Current Prevalence of Myopia and Association of Myopia with Environmental Factors among Schoolchildren in Japan

Yotsukura, E., Torii, H., Inokuchi, M., Tokumura, M., Uchino, M., Nakamura, K., Hyodo, M., Mori, K., Jiang, X., Ikeda, S. I., Kondo, S., Negishi, K., Kurihara, T. & Tsubota, K., 2019 Jan 1, (Accepted/In press) In : JAMA Ophthalmology.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes

Hishikawa, A., Hayashi, K., Abe, T., Kaneko, M., Yokoi, H., Azegami, T., Nakamura, M., Yoshimoto, N., Kanda, T., Sakamaki, Y. & Itoh, H., 2019 Jan 29, In : Cell Reports. 26, 5, p. 1318-1332.e4

Research output: Contribution to journalArticle

3 Citations (Scopus)

Effect of refrigeration of blood samples in lithium-heparin tubes on QuantiFERON TB Gold Plus test result

Uwamino, Y., Sakai, A., Nishimura, T., Noguchi, M., Uno, S., Fujiwara, H., Mori, M., Wakui, M., Murata, M. & Hasegawa, N., 2019 Jan 1, (Accepted/In press) In : Journal of Infection and Chemotherapy.

Research output: Contribution to journalArticle

Features of and preventive measures against hypertension in the young

Kawabe, H., Azegami, T., Takeda, A., Kanda, T., Saito, I., Saruta, T. & Hirose, H., 2019 Jan 1, In : Hypertension Research.

Research output: Contribution to journalReview article

Open Access
6 Citations (Scopus)
3 Citations (Scopus)

Low serum estradiol levels are related to Mycobacterium avium complex lung disease: A cross-sectional study

Uwamino, Y., Nishimura, T., Sato, Y., Tamizu, E., Asakura, T., Uno, S., Mori, M., Fujiwara, H., Ishii, M., Kawabe, H., Murata, M. & Hasegawa, N., 2019 Dec 16, In : BMC infectious diseases. 19, 1, 1055.

Research output: Contribution to journalArticle

Open Access

Mice lacking fat storage-inducing transmembrane protein 2 show improved profiles upon pressure overload-induced heart failure

Nishihama, N., Nagayama, T., Makino, S. & Koishi, R., 2019 Mar 1, In : Heliyon. 5, 3, e01292.

Research output: Contribution to journalArticle

Open Access

Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients

Higashikuse, Y., Mittal, N., Arimura, T., Yoon, S. H., Oda, M., Enomoto, H., Kaneda, R., Hattori, F., Suzuki, T., Kawakami, A., Gasch, A., Furukawa, T., Labeit, S., Fukuda, K., Kimura, A. & Makino, S., 2019 Jan 1, In : DMM Disease Models and Mechanisms. 12, 11, dmm.041103.

Research output: Contribution to journalArticle

Open Access

Retrospective evaluation of natural course in mild cases of Mycobacterium avium complex pulmonary disease

for the Non-Tuberculous Mycobacteriosis-Japan Research Consortium (NTM-JRC), 2019 Apr, In : PloS one. 14, 4, e0216034.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
Open Access
1 Citation (Scopus)

Sitafloxacin-containing regimen for the treatment of refractory mycobacterium avium complex lung disease

Asakura, T., Suzuki, S., Fukano, H., Okamori, S., Kusumoto, T., Uwamino, Y., Ogawa, T., So, M., Uno, S., Namkoong, H., Yoshida, M., Kamata, H., Ishii, M., Nishimura, T., Hoshino, Y. & Hasegawa, N., 2019 Apr, In : Open Forum Infectious Diseases. 6, 4, ofz108.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Type 2 inositol 1,4,5-trisphosphate receptor inhibits the progression of pulmonary arterial hypertension via calcium signaling and apoptosis

Shibata, A., Uchida, K., Kodo, K., Miyauchi, T., Mikoshiba, K., Takahashi, T. & Yamagishi, H., 2019 Apr 15, In : Heart and vessels. 34, 4, p. 724-734 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
Open Access

Versican is crucial for the initiation of cardiovascular lumen development in medaka (Oryzias latipes)

Mittal, N., Yoon, S. H., Enomoto, H., Hiroshi, M., Shimizu, A., Kawakami, A., Fujita, M., Watanabe, H., Fukuda, K. & Makino, S., 2019 Dec 1, In : Scientific reports. 9, 1, 9475.

Research output: Contribution to journalArticle

Open Access
2018

Aspergillus precipitating antibody in patients with Mycobacterium avium complex lung disease: A cross-sectional study

Suzuki, S., Asakura, T., Namkoong, H., Okamori, S., Yagi, K., Kamata, H., Uwamino, Y., Funatsu, Y., Nakano, Y., Nishimura, T., Ishii, M., Ebihara, T., Betsuyaku, T. & Hasegawa, N., 2018 May, In : Respiratory Medicine. 138, p. 1-6 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Association between six-minute walk test parameters and the health-related quality of life in patients with pulmonary Mycobacterium avium complex disease

Yagi, K., Asakura, T., Namkoong, H., Suzuki, S., Asami, T., Okamori, S., Kusumoto, T., Funatsu, Y., Kamata, H., Nishimura, T., Ishii, M., Betsuyaku, T. & Hasegawa, N., 2018 Jul 13, In : BMC Pulmonary Medicine. 18, 1, 114.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A tale of two sisters with hypertrophic cardiomyopathy and recurrent embolism: When is the optimal timing of the intervention for left atrial appendage?

Kimura, M., Kohno, T., Makino, S., Okuda, S., Nawata, K., Yanagisawa, R., Kojima, H., Nishiyama, T., Aizawa, Y., Yuasa, S., Murata, M., Maekawa, Y., Okamoto, K., Shimizu, H. & Fukuda, K., 2018 Jan 1, (Accepted/In press) In : Heart and Lung.

Research output: Contribution to journalArticle

Attitudes of pediatricians toward Children's consumption of ionic beverages

On behalf of the Committee on Pediatric Nutrition of The Japanese Pediatric Society, 2018 May 25, In : BMC Pediatrics. 18, 1, 176.

Research output: Contribution to journalArticle

Chronotropic incompetence to exercise in anorexia nervosa patients during the body-weight recovery phase as an index of insufficient treatment

Yoshida, Y., Maeda, J., Fukushima, H., Tokita, N., Yamagishi, H. & Tokumura, M., 2018 Jan 1, (Accepted/In press) In : Heart and Vessels.

Research output: Contribution to journalArticle

Clinical characteristics of pulmonary Mycobacterium lentiflavum disease in adult patients

Yagi, K., Morimoto, K., Ishii, M., Namkoong, H., Okamori, S., Asakura, T., Suzuki, S., Asami, T., Uwamino, Y., Funatsu, Y., Fujiwara, H., Kamata, H., Nishimura, T., Betsuyaku, T., Kurashima, A. & Hasegawa, N., 2018 Feb 1, In : International Journal of Infectious Diseases. 67, p. 65-69 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Clinico-microbiological analysis of 121 patients with pulmonary Mycobacteroides abscessus complex disease in Japan – An NTM-JRC study with RIT

Morimoto, K., Nakagawa, T., Asami, T., Morino, E., Fujiwara, H., Hase, I., Tsujimoto, Y., Izumi, K., Hayashi, Y., Matsuda, S., Murase, Y., Yano, R., Takasaki, J., Betsuyaku, T., Aono, A., Goto, H., Nishimura, T., Sasaki, Y., Hoshino, Y., Kurashima, A. & 4 others, Ato, M., Ogawa, K., Hasegawa, N. & Mitarai, S., 2018 Dec, In : Respiratory Medicine. 145, p. 14-20 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Epidermal growth factor receptor/extracellular signal-regulated kinase pathway enhances mineralocorticoid receptor transcriptional activity through protein stabilization

Mitsuishi, Y., Shibata, H., Kurihara, I., Kobayashi, S., Yokota, K., Murai-Takeda, A., Hayashi, T., Jo, R., Nakamura, T., Morisaki, M. & Itoh, H., 2018 Sep 15, In : Molecular and Cellular Endocrinology. 473, p. 89-99 11 p.

Research output: Contribution to journalArticle

Estimating latent tuberculosis infection using interferon-γ release assay, Japan

Nishimura, T., Ota, M., Mori, M., Hasegawa, N., Kawabe, H. & Kato, S., 2018 Nov 1, In : Emerging Infectious Diseases. 24, 11, p. 2111-2113 3 p.

Research output: Contribution to journalLetter

Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21

Tanikawa, C., Kamatani, Y., Toyoshima, O., Sakamoto, H., Ito, H., Takahashi, A., Momozawa, Y., Hirata, M., Fuse, N., Takai-Igarashi, T., Shimizu, A., Sasaki, M., Yamaji, T., Sawada, N., Iwasaki, M., Tsugane, S., Naito, M., Hishida, A., Wakai, K., Furusyo, N. & 13 others, Murakami, Y., Nakamura, Y., Imoto, I., Inazawa, J., Oze, I., Sato, N., Tanioka, F., Sugimura, H., Hirose, H., Yoshida, T., Matsuo, K., Kubo, M. & Matsuda, K., 2018 Dec, In : Cancer science. 109, 12, p. 4015-4024 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Intestinal mineralocorticoid receptor contributes to epithelial sodium channel–mediated intestinal sodium absorption and blood pressure regulation

Nakamura, T., Kurihara, I., Kobayashi, S., Yokota, K., Murai-Takeda, A., Mitsuishi, Y., Morisaki, M., Kohata, N., Oshima, Y., Minami, Y., Shibata, H. & Itoh, H., 2018 Jul 1, In : Journal of the American Heart Association. 7, 13, e008259.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Intranasal vaccination against angiotensin II type 1 receptor and pneumococcal surface protein A attenuates hypertension and pneumococcal infection in rodents

Azegami, T., Yuki, Y., Hayashi, K., Hishikawa, A., Sawada, S. I., Ishige, K., Akiyoshi, K., Kiyono, H. & Itoh, H., 2018 Feb 1, In : Journal of Hypertension. 36, 2, p. 387-394 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Demenais, F., Margaritte-Jeannin, P., Barnes, K. C., Cookson, W. O. C., Altmüller, J., Ang, W., Barr, R. G., Beaty, T. H., Becker, A. B., Beilby, J., Bisgaard, H., Bjornsdottir, U. S., Bleecker, E., Bønnelykke, K., Boomsma, D. I., Bouzigon, E., Brightling, C. E., Brossard, M., Brusselle, G. G., Burchard, E. & 155 others, Burkart, K. M., Bush, A., Chan-Yeung, M., Chung, K. F., Couto Alves, A., Curtin, J. A., Custovic, A., Daley, D., De Jongste, J. C., Del-Rio-Navarro, B. E., Donohue, K. M., Duijts, L., Eng, C., Eriksson, J. G., Farrall, M., Fedorova, Y., Feenstra, B., Ferreira, M. A., Freidin, M. B., Gajdos, Z., Gauderman, J., Gehring, U., Geller, F., Genuneit, J., Gharib, S. A., Gilliland, F., Granell, R., Graves, P. E., Gudbjartsson, D. F., Haahtela, T., Heckbert, S. R., Heederik, D., Heinrich, J., Heliövaara, M., Henderson, J., Himes, B. E., Hirose, H., Hirschhorn, J. N., Hofman, A., Holt, P., Hottenga, J., Hudson, T. J., Hui, J., Imboden, M., Ivanov, V., Jaddoe, V. W. V., James, A., Janson, C., Jarvelin, M. R., Jarvis, D., Jones, G., Jonsdottir, I., Jousilahti, P., Kabesch, M., Kähönen, M., Kantor, D. B., Karunas, A. S., Khusnutdinova, E., Koppelman, G. H., Kozyrskyj, A. L., Kreiner, E., Kubo, M., Kumar, R., Kumar, A., Kuokkanen, M., Lahousse, L., Laitinen, T., Laprise, C., Lathrop, M., Lau, S., Lee, Y. A., Lehtimäki, T., Letort, S., Levin, A. M., Li, G., Liang, L., Loehr, L. R., London, S. J., Loth, D. W., Manichaikul, A., Marenholz, I., Martinez, F. J., Matheson, M. C., Mathias, R. A., Matsumoto, K., Mbarek, H., McArdle, W. L., Melbye, M., Melén, E., Meyers, D., Michel, S., Mohamdi, H., Musk, A. W., Myers, R. A., Nieuwenhuis, M. A. E., Noguchi, E., O'Connor, G. T., Ogorodova, L. M., Palmer, C. D., Palotie, A., Park, J. E., Pennell, C. E., Pershagen, G., Polonikov, A., Postma, D. S., Probst-Hensch, N., Puzyrev, V. P., Raby, B. A., Raitakari, O. T., Ramasamy, A., Rich, S. S., Robertson, C. F., Romieu, I., Salam, M. T., Salomaa, V., Schlünssen, V., Scott, R., Selivanova, P. A., Sigsgaard, T., Simpson, A., Siroux, V., Smith, L. J., Solodilova, M., Standl, M., Stefansson, K., Strachan, D. P., Stricker, B. H., Takahashi, A., Thompson, P. J., Thorleifsson, G., Thorsteinsdottir, U., Tiesler, C. M. T., Torgerson, D. G., Tsunoda, T., Uitterlinden, A. G., Van Der Valk, R. J. P., Vaysse, A., Vedantam, S., Von Berg, A., Von Mutius, E., Vonk, J. M., Waage, J., Wareham, N. J., Weiss, S. T., White, W. B., Wickman, M., Widén, E., Willemsen, G., Williams, L. K., Wouters, I. M., Yang, J. J., Zhao, J. H., Moffatt, M. F., Ober, C. & Nicolae, D. L., 2018 Jan 1, In : Nature genetics. 50, 1, p. 42-50 9 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)

Nanogel-based nasal vaccines for infectious and lifestyle-related diseases

Azegami, T., Yuki, Y., Nakahashi, R., Itoh, H. & Kiyono, H., 2018 Jun, In : Molecular Immunology. 98, p. 19-24 6 p.

Research output: Contribution to journalReview article

5 Citations (Scopus)

Natural history of Mycobacterium fortuitum pulmonary infection presenting with migratory infiltrates: A case report with microbiological analysis

Okamori, S., Asakura, T., Nishimura, T., Tamizu, E., Ishii, M., Yoshida, M., Fukano, H., Hayashi, Y., Fujita, M., Hoshino, Y., Betsuyaku, T. & Hasegawa, N., 2018 Jan 2, In : BMC Infectious Diseases. 18, 1, 1.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Prevalence of central fatness in 1992–1994: 40% of Japanese boys 6–17 years

Inokuchi, M., Matsuo, N., Takayama, J. I. & Hasegawa, T., 2018 Jan 1, In : Endocrine journal. 65, 2, p. 213-220 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Risk of tuberculosis infection among health care workers and nursing students in Japan

Nishimura, T., Ota, M., Mori, M., Fujiwara, H., Takano, Y., Kato, S., Kawabe, H. & Hasegawa, N., 2018 Jan 1, (Accepted/In press) In : Journal of Infection and Chemotherapy.

Research output: Contribution to journalArticle

3 Citations (Scopus)

School-age children and adolescents suspected of having been to be infected with pertussis in Japan

Yasui, Y., Mitsui, T., Nishimura, T., Uchida, K., Inokuchi, M., Mori, M., Tokumura, M. & Nakayama, T., 2018 May 11, In : Vaccine. 36, 20, p. 2910-2915 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Selective modulation of local linkages between active transcription and oxidative demethylation activity shapes cardiomyocyte-specific gene-body epigenetic status in mice

Oda, M., Wakabayashi, S., Ari Wijetunga, N., Yuasa, S., Enomoto, H., Kaneda, R., Yoon, S. H., Mittal, N., Jing, Q., Suzuki, M., Greally, J. M., Fukuda, K. & Makino, S., 2018 May 10, In : BMC Genomics. 19, 1, 349.

Research output: Contribution to journalArticle

Temporal trends in renal function and birthweight in Japanese adolescent males (1998-2015)

Kanda, T., Takeda, A., Hirose, H., Abe, T., Urai, H., Inokuchi, M., Wakino, S., Tokumura, M., Itoh, H. & Kawabe, H., 2018 Feb 1, In : Nephrology Dialysis Transplantation. 33, 2, p. 304-310 7 p.

Research output: Contribution to journalReview article

4 Citations (Scopus)
7 Citations (Scopus)

WHO 2006 Child Growth Standards overestimate short stature and underestimate overweight in Japanese children

Inokuchi, M., Matsuo, N., Takayama, J. I. & Hasegawa, T., 2018 Jan 26, In : Journal of Pediatric Endocrinology and Metabolism. 31, 1, p. 33-38 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2017

Bcl-x L mediates RIPK3-dependent necrosis in M. tuberculosis-infected macrophages

Zhao, X., Khan, N., Gan, H., Tzelepis, F., Nishimura, T., Park, S. Y., Divangahi, M. & Remold, H. G., 2017 Nov 1, In : Mucosal Immunology. 10, 6, p. 1553-1568 16 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

High glucose stimulates mineralocorticoid receptor transcriptional activity through the protein kinase C β signaling

Hayashi, T., Shibata, H., Kurihara, I., Yokota, K., Mitsuishi, Y., Ohashi, K., Murai-Takeda, A., Jo, R., Ohyama, T., Sakamoto, M., Tojo, K., Tajima, N., Utsunomiya, K. & Itoh, H., 2017 Sep, In : International Heart Journal. 58, 5, p. 794-802 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Hsa-miR-346 is a potential serum biomarker of Mycobacterium avium complex pulmonary disease activity

Nishimura, T., Tamizu, E., Uno, S., Uwamino, Y., Fujiwara, H., Nishio, K., Nakano, Y., Shiono, H., Namkoong, H., Hoshino, Y., Iwata, S. & Hasegawa, N., 2017, (Accepted/In press) In : Journal of Infection and Chemotherapy.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Impact of chronic Pseudomonas aeruginosa infection on health-related quality of life in Mycobacterium avium complex lung disease

Kamata, H., Asakura, T., Suzuki, S., Namkoong, H., Yagi, K., Funatsu, Y., Okamori, S., Uno, S., Uwamino, Y., Fujiwara, H., Nishimura, T., Ishii, M., Betsuyaku, T. & Hasegawa, N., 2017 Dec 13, In : BMC Pulmonary Medicine. 17, 1, 198.

Research output: Contribution to journalArticle

6 Citations (Scopus)