Research Output 1987 2019

2002
6 Citations (Scopus)

A novel polymorphism, 70Leu/Phe, disrupts a consensus Leu residue within the leucine-rich repeat sequence of platelet glycoprotein Ibα

Matsubara, Y., Murata, M., Moriki, T., Yokoyama, K., Watanabe, N., Nakajima, H., Handa, M., Kawano, K., Aoki, N., Yoshino, H. & Ikeda, Y., 2002, In : Thrombosis and Haemostasis. 87, 5, p. 867-872 6 p.

Research output: Contribution to journalArticle

Platelet Glycoprotein GPIb-IX Complex
Platelet Membrane Glycoproteins
von Willebrand Factor
Leucine
Ristocetin
182 Citations (Scopus)

Bone marrow-derived regenerated cardiomyocytes (CMG cells) express functional adrenergic and muscarinic receptors

Hakuno, D., Fukuda, K., Makino, S., Konishi, F., Tomita, Y., Manabe, T., Suzuki, Y., Umezawa, A. & Ogawa, S., 2002 Jan 22, In : Circulation. 105, 3, p. 380-386 7 p.

Research output: Contribution to journalArticle

Muscarinic Receptors
Cardiac Myocytes
Adrenergic Receptors
Isoproterenol
Bone Marrow
421 Citations (Scopus)

Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population

Yamamoto, Y., Hirose, H., Saito, I., Tomita, M., Taniyama, M., Matsubara, K., Okazaki, Y., Ishii, T., Nishikai, K. & Saruta, T., 2002, In : Clinical Science. 103, 2, p. 137-142 6 p.

Research output: Contribution to journalArticle

Adiponectin
Adipocytes
HDL Cholesterol
Insulin Resistance
Body Mass Index
201 Citations (Scopus)

Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes

Hirose, H., Kawai, T., Yamamoto, Y., Taniyama, M., Tomita, M., Matsubara, K., Okazaki, Y., Ishii, T., Oguma, Y., Takei, I. & Saruta, T., 2002, In : Metabolism: Clinical and Experimental. 51, 3, p. 314-317 4 p.

Research output: Contribution to journalArticle

pioglitazone
Body Fat Distribution
Adiponectin
Type 2 Diabetes Mellitus
Subcutaneous Fat
16 Citations (Scopus)
Homeobox Genes
Estrogens
Leg
Growth
Gene Duplication
7 Citations (Scopus)

Impaired cardiorespiratory response to brief sudden strenuous exercise in the postoperative tetralogy of Fallot patients: A ten-second pedaling test

Tokumura, M., Yoshiba, S., Kojima, Y. & Nanri, S., 2002 Sep, In : Pediatric Cardiology. 23, 5, p. 496-501 6 p.

Research output: Contribution to journalArticle

Tetralogy of Fallot
Foot
Exercise
Exercise Test
Heart Rate
30 Citations (Scopus)
Endotoxins
Liver
Lipopolysaccharides
Rats
Ethanol
60 Citations (Scopus)

PPAR(gamma)2 gene Pro12Ala polymorphism may influence serum level of an adipocyte-derived protein, adiponectin, in the Japanese population.

Yamamoto, Y., Hirose, H., Miyashita, K., Nishikai, K., Saito, I., Taniyama, M., Tomita, M. & Saruta, T., 2002 Nov, In : Metabolism: Clinical and Experimental. 51, 11, p. 1407-1409 3 p.

Research output: Contribution to journalArticle

PPAR gamma
Adiponectin
Adipocytes
Serum
Population
19 Citations (Scopus)
gamma-Glutamyltransferase
Guanosine Triphosphate
Insulin Resistance
Insulin
Serum
26 Citations (Scopus)

Trends in pharmacologic management of hypertension in Japan one year after the publication of the JSH 2000 guidelines

Saito, I., Kawabe, H., Tsujioka, M., Hirose, H. & Shibata, H., 2002, In : Hypertension Research. 25, 2, p. 175-178 4 p.

Research output: Contribution to journalArticle

Publications
Japan
Guidelines
Hypertension
Calcium
18 Citations (Scopus)

Troglitazone ameliorates lipotoxicity in the beta cell line INS-1 expressing PPAR gamma

Kawai, T., Hirose, H., Seto, Y., Fujita, H., Fujita, H., Ukeda, K. & Saruta, T., 2002, In : Diabetes Research and Clinical Practice. 56, 2, p. 83-92 10 p.

Research output: Contribution to journalArticle

troglitazone
PPAR gamma
Cell Line
Insulin
Diazoxide
18 Citations (Scopus)

Xanthine oxidase-derived oxygen radicals play significant roles in the development of chronic pancreatitis in WBN/Kob rats

Zeki, S., Miura, S., Suzuki, H., Watanabe, N., Adachi, M., Yokoyama, H., Horie, Y., Saito, H., Kato, S. & Ishii, H., 2002, In : Journal of Gastroenterology and Hepatology (Australia). 17, 5, p. 606-616 11 p.

Research output: Contribution to journalArticle

Xanthine Oxidase
Chronic Pancreatitis
Lithostathine
Reactive Oxygen Species
Tungsten
2001
12 Citations (Scopus)

Alcohol dehydrogenase activities in the human gastric mucosa: Effects of Helicobacter pylori infection, sex, age, and the part of the stomach

Matsumoto, M., Yokoyama, H., Shiraishi, H., Suzuki, H., Kato, S., Miura, S. & Ishii, H., 2001, In : Alcoholism: Clinical and Experimental Research. 25, 6 SUPPL.

Research output: Contribution to journalArticle

Alcohol Dehydrogenase
Helicobacter Infections
Gastric Mucosa
Human Activities
Helicobacter pylori
69 Citations (Scopus)

Autoimmunity against the second extracellular loop of β1-adrenergic receptors induces β-adrenergic receptor desensitization and myocardial hypertrophy in vivo

Iwata, M., Yoshikawa, T., Baba, A., Anzai, T., Nakamura, I., Wainai, Y., Takahashi, T. & Ogawa, S., 2001 Mar 30, In : Circulation Research. 88, 6, p. 578-586 9 p.

Research output: Contribution to journalArticle

Autoimmunity
Adrenergic Receptors
Hypertrophy
Rabbits
Bisoprolol
32 Citations (Scopus)

Cholesteryl ester transfer protein polymorphism associated with macroangiopathy in Japanese patients with type 2 diabetes

Meguro, S., Takei, I., Murata, M., Hirose, H., Takei, N., Mitsuyoshi, Y., Ishii, K., Oguchi, S., Shinohara, J., Takeshita, E., Watanabe, K. & Saruta, T., 2001 May, In : Atherosclerosis. 156, 1, p. 151-156 6 p.

Research output: Contribution to journalArticle

Cholesterol Ester Transfer Proteins
Type 2 Diabetes Mellitus
Genotype
Blood Proteins
Inteins
21 Citations (Scopus)

Chronic effects of different fatty acids and leptin in INS-1 cells

Kawai, T., Hirose, H., Seto, Y., Fujita, H. & Saruta, T., 2001 Jan 1, In : Diabetes Research and Clinical Practice. 51, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Leptin
Fatty Acids
Insulin
Cell Survival
Palmitic Acid
48 Citations (Scopus)

Chronic ethanol consumption exacerbates microcirculatory damage in rat mesentery after reperfusion

Han, J. Y., Miura, S., Akiba, Y., Higuchi, H., Kato, S., Suzuki, H., Yokoyama, H. & Ishii, H., 2001 May, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 280, 5 43-5

Research output: Contribution to journalArticle

Mesentery
Venules
Reperfusion
Ethanol
Glutathione
29 Citations (Scopus)
Fatty Acid-Binding Proteins
Adrenergic Receptors
Insulin Resistance
Fasting
Genotype
29 Citations (Scopus)

NeuroD/BETA2 gene G→A polymorphism may affect onset pattern of type 1 diabetes in Japanese

Yamada, S., Motohashi, Y., Yanagawa, T., Maruyama, T., Kasuga, A., Hirose, H., Matsubara, K., Shimada, A. & Saruta, T., 2001, In : Diabetes Care. 24, 8, p. 1438-1441 4 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Autoantibodies
Genes
Regeneration
Cell Differentiation
10 Citations (Scopus)
Acetaldehyde
Gastric Mucosa
Tretinoin
Vitamin A
NAD
10 Citations (Scopus)

Relationships between baseline serum leptin levels and 2-year changes in body mass index, blood pressure and metabolic parameters in Japanese male adolescents and middle-aged men

Hirose, H., Saito, I., Kawai, T., Tsujioka, M., Kawabe, H. & Saruta, T., 2001, In : Clinical Science. 100, 2, p. 145-150 6 p.

Research output: Contribution to journalArticle

Leptin
Body Mass Index
Blood Pressure
Serum
Heart Rate
28 Citations (Scopus)

Simultaneous quantification of retinol, retinal, and retinoic acid isomers by high-performance liquid chromatography with a simple gradiation

Miyagi, M., Yokoyama, H., Shiraishi, H., Matsumoto, M. & Ishii, H., 2001 Jun 15, In : Journal of Chromatography B: Biomedical Sciences and Applications. 757, 2, p. 365-368 4 p.

Research output: Contribution to journalArticle

High performance liquid chromatography
Tretinoin
Vitamin A
Isomers
2-Propanol
11 Citations (Scopus)

Vasculitis associated with septicemia: Case report and review of the literature

Kodo, K., Hida, M., Omori, S., Mori, T., Tokumura, M., Kuramochi, S. & Awazu, M., 2001, In : Pediatric Nephrology. 16, 12, p. 1089-1092 4 p.

Research output: Contribution to journalArticle

Glomerulonephritis
Vasculitis
Endocarditis
Systemic Vasculitis
Sepsis
2000

A new polymorphism, '"leu/phe, within the leucine-rich repeat sequence of platelet glycoprotein ibo

Matsubara, Y., Murata, M., Moriki, T., Yokoyama, K., Watanabe, N., Nakajima, H., Handa, M. & Ikeda, Y., 2000, In : Blood. 96, 11 PART II

Research output: Contribution to journalArticle

Platelet Membrane Glycoproteins
Polymorphism
Leucine
Platelets
Platelet Glycoprotein GPIb-IX Complex
19 Citations (Scopus)

Determinants for the development of hypertension in adolescents. A 6-year follow-up

Kawabe, H., Shibata, H., Hirose, H., Tsujioka, M., Saito, I. & Saruta, T., 2000, In : Journal of Hypertension. 18, 11, p. 1557-1561 5 p.

Research output: Contribution to journalArticle

Blood Pressure
Hypertension
Blood Group Antigens
Body Mass Index
Students
62 Citations (Scopus)

Effect of acute ethanol administration on the intestinal absorption of endotoxin in rats

Tamai, H., Kato, S., Horie, Y., Ohki, E., Yokoyama, H. & Ishii, H., 2000 Mar, In : Alcoholism: Clinical and Experimental Research. 24, 3, p. 390-394 5 p.

Research output: Contribution to journalArticle

Intestinal Absorption
Endotoxins
Rats
Ethanol
Small Intestine
25 Citations (Scopus)

Effects of body weight control on changes in blood pressure: Three-year follow-up study in young Japanese individuals

Hirose, H., Saito, I., Tsujioka, M., Kawabe, H. & Saruta, T., 2000, In : Hypertension Research. 23, 5, p. 421-426 6 p.

Research output: Contribution to journalArticle

Body Weight Changes
Body Weight
Blood Pressure
Students
Body Mass Index
69 Citations (Scopus)

Frequent association of 22q11.2 deletion with tetralogy of Fallot

Maeda, J., Yamagishi, H., Matsuoka, R., Ishihara, J., Tokumura, M., Fukushima, H., Ueda, H., Takahashi, E., Yoshiba, S. & Kojima, Y., 2000 Jun 5, In : American Journal of Medical Genetics. 92, 4, p. 269-272 4 p.

Research output: Contribution to journalArticle

Tetralogy of Fallot
Pulmonary Atresia
Bronchomalacia
DiGeorge Syndrome
Pulmonary Artery
8 Citations (Scopus)

Glutathione depletion enhances the formation of superoxide anion released into hepatic sinusoids after lipopolysaccharide challenge

Moriya, S., Yokoyama, H., Fukuda, M., Okamura, Y., Kamegaya, Y., Mizukami, T., Ohgo, H. & Ishii, H., 2000 Apr, In : Alcoholism: Clinical and Experimental Research. 24, 4 SUPPL.

Research output: Contribution to journalArticle

Superoxides
Glutathione
Lipopolysaccharides
Liver
Rats
189 Citations (Scopus)

Interleukin-6 family of cytokines mediate angiotensin II-induced cardiac hypertrophy in rodent cardiomyocytes

Sano, M., Fukuda, K., Kodama, H., Pan, J., Saito, M., Matsuzaki, J., Takahashi, T., Makino, S., Kato, T. & Ogawa, S., 2000 Sep 22, In : Journal of Biological Chemistry. 275, 38, p. 29717-29723 7 p.

Research output: Contribution to journalArticle

Leukemia Inhibitory Factor
Cardiomegaly
Cardiac Myocytes
Angiotensin II
Rodentia
21 Citations (Scopus)

Participation in school sports clubs and related effects on cardiovascular risk factors in young males

Kawabe, H., Murata, K., Shibata, H., Hirose, H., Tsujioka, M., Saito, I. & Saruta, T., 2000 May, In : Hypertension Research. 23, 3, p. 227-232 6 p.

Research output: Contribution to journalArticle

Sports
Exercise
Adipose Tissue
Students
Blood Pressure
3 Citations (Scopus)

Presynaptic modulation of the norepinephrine-induced β-adrenergic receptor desensitization phenomenon in vivo

Nakamura, I., Yoshikawa, T., Anzai, T., Baba, A., Iwata, M., Wainai, Y., Suzuki, M. & Ogawa, S., 2000, In : Journal of Cardiac Failure. 6, 4, p. 350-358 9 p.

Research output: Contribution to journalArticle

Adrenergic Receptors
Norepinephrine
Rabbits
Isoproterenol
Adenylyl Cyclases
17 Citations (Scopus)

Risk factors associated with persistent postoperative hypertension in Cushing's syndrome

Suzuki, T., Shibata, H., Ando, T., Kurihara, I., Kobayashi, S., Hayashi, K., Hayashi, M., Kawabe, H., Saito, I., Murai, M. & Saruta, T., 2000, In : Endocrine Research. 26, 4, p. 791-795 5 p.

Research output: Contribution to journalArticle

Cushing Syndrome
Hypertension
Hydrocortisone
Adrenocortical Adenoma
Age Factors
65 Citations (Scopus)

Significance of ERK cascade compared with JAK/STAT and PI3-K pathway in gp130-mediated cardiac hypertrophy

Kodama, H., Fukuda, K., Pan, J., Sano, M., Takahashi, T., Kato, T., Makino, S., Manabe, T., Murata, M. & Ogawa, S., 2000, In : American Journal of Physiology - Heart and Circulatory Physiology. 279, 4 48-4

Research output: Contribution to journalArticle

Janus Kinases
Cardiomegaly
Leukemia Inhibitory Factor
Transcriptional Activation
Signal Transduction
8 Citations (Scopus)

Simultaneous quantification of various retinoids by high performance liquid chromatography: Its relevance to alcohol research

Yokoyama, H., Matsumoto, M., Shiraishi, H. & Ishii, H., 2000 Apr, In : Alcoholism: Clinical and Experimental Research. 24, 4 SUPPL.

Research output: Contribution to journalArticle

Retinoids
High performance liquid chromatography
High Pressure Liquid Chromatography
Alcohols
Tretinoin
43 Citations (Scopus)

Tumor necrosis factor alpha gene G-308A polymorphism, insulin resistance, and fasting plasma glucose in young, older, and diabetic Japanese men

Ishii, T., Hirose, H., Saito, I., Nishikai, K., Maruyama, H. & Saruta, T., 2000, In : Metabolism: Clinical and Experimental. 49, 12, p. 1616-1618 3 p.

Research output: Contribution to journalArticle

Insulin Resistance
Fasting
Tumor Necrosis Factor-alpha
Leptin
Glucose
11 Citations (Scopus)

Ventricular septal defect associated with microdeletions of chromosome 22q11.2

Yamagishi, H., Maeda, J., Tokumura, M., Yoshiba, S., Takahashi, E., Fukushima, H., Yamagishi, C., Matsuo, N. & Kojima, Y., 2000, In : Clinical Genetics. 58, 6, p. 493-496 4 p.

Research output: Contribution to journalArticle

Ventricular Heart Septal Defects
Chromosomes
DiGeorge Syndrome
Chromosomes, Human, Pair 22
1999
1629 Citations (Scopus)

Cardiomyocytes can be generated from marrow stromal cells in vitro

Makino, S., Fukuda, K., Miyoshi, S., Konishi, F., Kodama, H., Pan, J., Sano, M., Takahashi, T., Hori, S., Abe, H., Hata, J. I., Umezawa, A. & Ogawa, S., 1999 Mar, In : Journal of Clinical Investigation. 103, 5, p. 697-705 9 p.

Research output: Contribution to journalArticle

Stromal Cells
Cardiac Myocytes
Bone Marrow
Azacitidine
Action Potentials
44 Citations (Scopus)

Characterization of insulin-like growth factor-1-induced activation of the JAK/STAT pathway in rat cardiomyocytes

Takahashi, T., Fukuda, K., Pan, J., Kodama, H., Sano, M., Makino, S., Kato, T., Manabe, T. & Ogawa, S., 1999 Nov 12, In : Circulation Research. 85, 10, p. 884-891 8 p.

Research output: Contribution to journalArticle

Janus Kinases
Somatomedins
Transducers
Cardiac Myocytes
Phosphorylation
63 Citations (Scopus)

Clinical and immunoregulatory effects of roxithromycin therapy for chronic respiratory tract infection

Nakamura, H., Fujishima, S., Inoue, T., Ohkubo, Y., Soejima, K., Waki, Y., Mori, M., Urano, T., Sakamaki, F., Tasaka, S., Ishizaka, A., Kanazawa, M. & Yamaguchi, K., 1999, In : European Respiratory Journal. 13, 6, p. 1371-1379 9 p.

Research output: Contribution to journalArticle

Roxithromycin
Respiratory Tract Infections
Interleukin-8
Leukocyte Elastase
Neutrophils
79 Citations (Scopus)

Effects of troglitazone on fat distribution in the treatment of male type 2 diabetes

Kawai, T., Takei, I., Oguma, Y., Ohashi, N., Tokui, M., Oguchi, S., Katsukawa, F., Hirose, H., Shimada, A., Watanabe, K. & Saruta, T., 1999, In : Metabolism: Clinical and Experimental. 48, 9, p. 1102-1107 6 p.

Research output: Contribution to journalArticle

troglitazone
Type 2 Diabetes Mellitus
Subcutaneous Fat
Fats
Intra-Abdominal Fat
14 Citations (Scopus)

Evidence for ethanol oxidation by Kupffer cells

Nakamura, Y., Yokoyama, H., Okamura, Y., Ohgo, H., Fukuda, M., Horie, Y., Kato, S. & Ishii, H., 1999 Apr, In : Alcoholism: Clinical and Experimental Research. 23, 4 SUPPL.

Research output: Contribution to journalArticle

Kupffer Cells
Ethanol
Aldehyde Dehydrogenase
Acetates
Oxidation
38 Citations (Scopus)

Lack of association between CTLA-4 gene polymorphism and IDDM in Japanese subjects

Yanagawa, T., Maruyama, T., Gomi, K., Taniyama, M., Kasuga, A., Ozawa, Y., Terauchi, M., Hirose, H., Maruyama, H. & Saruta, T., 1999, In : Autoimmunity. 29, 1, p. 53-56 4 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Genes
Antibodies
Alleles
T-Lymphocytes
3 Citations (Scopus)

Major role of cytochrome P450 2E1 in ethanol oxidation by Kupffer cells

Nakamura, Y., Yokoyama, H., Kato, S. & Ishii, H., 1999, In : Research Communications in Alcohol and Substances of Abuse. 20, 1-2, p. 15-25 11 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
Kupffer Cells
Ethanol
Oxidation
Acetates
21 Citations (Scopus)

Sexual differences in relationships between birth weight or current body weight and blood pressure or cholesterol in young Japanese students

Kawabe, H., Shibata, H., Hirose, H., Tsujioka, M., Saito, I. & Saruta, T., 1999 Sep, In : Hypertension Research - Clinical and Experimental. 22, 3, p. 169-172 4 p.

Research output: Contribution to journalArticle

Birth Weight
Cholesterol
Body Weight
Students
Blood Pressure
29 Citations (Scopus)

Superoxide anion release into the hepatic sinusoid after an acute ethanol challenge and its attenuation by Kupffer cell depletion

Yokoyama, H., Fukuda, M., Okamura, Y., Mizukami, T., Ohgo, H., Kamegaya, Y., Kato, S. & Ishii, H., 1999 Apr, In : Alcoholism: Clinical and Experimental Research. 23, 4 SUPPL.

Research output: Contribution to journalArticle

Kupffer Cells
Superoxides
Ethanol
Liver
Endothelial cells
1 Citation (Scopus)
Leptin
Hyperlipidemias
Longitudinal Studies
Insulin Resistance
Japan
2 Citations (Scopus)

White coat hypertension in two adolescents

Yamaguchi, Y., Awazu, M., Matsuoka, S., Maeda, J., Tokumura, M., Kojima, Y. & Matsuo, N., 1999 Jan, In : Pediatric Nephrology. 13, 1, p. 60-62 3 p.

Research output: Contribution to journalArticle

White Coat Hypertension
Hypertension
Reference Values
Blood Pressure
1998
25 Citations (Scopus)

Augmented levels of gastric mucosal leucocyte activation by infection with cagA gene-positive Helicobacter pylori

Suzuki, H., Suzuki, M., Mori, M., Kitahora, T., Yokoyama, H., Miura, S., Hibi, T. & Ishii, H., 1998, In : Journal of Gastroenterology and Hepatology (Australia). 13, 3, p. 294-300 7 p.

Research output: Contribution to journalArticle

Helicobacter pylori
Stomach
Leukocytes
Infection
Reactive Oxygen Species
1 Citation (Scopus)

Baroreceptor sensitivity during the compensatory phase of left ventricular overloading

Nishimura, H., Yoshikawa, T., Anzai, T., Baba, A., Kobayashi, N., Wainai, Y. & Ogawa, S., 1998 Oct, In : Japanese Circulation Journal. 62, 10, p. 773-778 6 p.

Research output: Contribution to journalArticle

Pressoreceptors
Aortic Valve Insufficiency
Rabbits
Heart Rate
Blood Pressure