Center for Supercentenarian Medical Research

Research output

Research output per year 1995 2001 2003 2007 2014 2015 2017 2018 2019 2020 2021 2022 2023

• 127 Article
• 20 Letter
• 11 Review article
• 2 Comment/debate
• 1 More
  • 1 Chapter

Research output per year

Research output per year

Search results

• Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population

  Hirota, T., Takahashi, A., Kubo, M., Tsunoda, T., Tomita, K., Sakashita, M., Yamada, T., Fujieda, S., Tanaka, S., Doi, S., Miyatake, A., Enomoto, T., Nishiyama, C., Nakano, N., Maeda, K., Okumura, K., Ogawa, H., Ikeda, S., Noguchi, E., Sakamoto, T., & 10 othersHizawa, N., Ebe, K., Saeki, H., Sasaki, T., Ebihara, T., Amagai, M., Takeuchi, S., Furue, M., Nakamura, Y. & Tamari, M., 2012 Nov, In: Nature genetics. 44, 11, p. 1222-1226 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Atopic Dermatitis 100%
  • Genome-Wide Association Study 99%
  • Vitamin D3 24-Hydroxylase 37%
  • Population 37%
  • Interleukin-13 27%
  254 Citations (Scopus)

• Genomic organization of the sex-determining and adjacent regions of the sex chromosomes of medaka

  Kondo, M., Hornung, U., Nanda, I., Imai, S., Sasaki, T., Shimizu, A., Asakawa, S., Hori, H., Schmid, M., Shimizu, N. & Schartl, M., 2006, In: Genome Research. 16, 7, p. 815-826 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oryzias 100%
  • Sex Chromosomes 89%
  • Y Chromosome 55%
  • Chromosomes, Human, Y 36%
  • Nucleic Acid Repetitive Sequences 27%
  124 Citations (Scopus)

• Genomic sequences encoding two types of medaka hemopexin-like protein Wap65, and their gene expression profiles in embryos

  Nakaniwa, M., Hirayama, M., Shimizu, A., Sasaki, T., Asakawa, S., Shimizu, N. & Watabe, S., 2005 May, In: Journal of Experimental Biology. 208, 10, p. 1915-1925 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Hemopexin 100%
  • Oryzias 95%
  • bud 82%
  • gene expression 75%
  • ontogeny 74%
  27 Citations (Scopus)

• Global gene expression analysis following spinal cord injury in non-human primates

  Nishimura, S., Sasaki, T., Shimizu, A., Yoshida, K., Iwai, H., Koya, I., Kobayashi, Y., Itakura, G., Shibata, S., Ebise, H., Horiuchi, K., Kudo, J., Toyama, Y., Anderson, A. J., Okano, H. & Nakamura, M., 2014 Nov, In: Experimental Neurology. 261, p. 171-179 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Spinal Cord Injuries 100%
  • Primates 97%
  • Gene Expression 62%
  • Callithrix 27%
  • Rodentia 25%
  18 Citations (Scopus)

• Group multi-component programme based on cognitive behavioural therapy and positive psychology for family caregivers of people with dementia: a randomised controlled study (3C study)

  Tamura, N. T., Shikimoto, R., Nagashima, K., Sato, Y., Nakagawa, A., Irie, S., Iwashita, S., Mimura, M. & Fujisawa, D., 2023 Jan, In: Psychogeriatrics. 23, 1, p. 141-156 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Positive Psychology 100%
  • Cognitive Behavioral Therapy 66%
  • Caregivers 55%
  • Dementia 54%
  • Emotions 34%

• HER2 heterogeneity is associated with poor survival in HER2-positive breast cancer

  Hosonaga, M., Arima, Y., Sampetrean, O., Komura, D., Koya, I., Sasaki, T., Sato, E., Okano, H., Kudoh, J., Ishikawa, S., Saya, H. & Ishikawa, T., 2018 Aug, In: International journal of molecular sciences. 19, 8, 2158.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Epidermal Growth Factor 100%
  • human ERBB2 protein 70%
  • breast 60%
  • cancer 54%
  • Heterogeneity 53%
  15 Citations (Scopus)

• Human induced pluripotent stem cell-derived ectodermal precursor cells contribute to hair follicle morphogenesis in vivo

  Veraitch, O., Kobayashi, T., Imaizumi, Y., Akamatsu, W., Sasaki, T., Yamanaka, S., Amagai, M., Okano, H. & Ohyama, M., 2013 Jun, In: Journal of Investigative Dermatology. 133, 6, p. 1479-1488 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Hair Follicle 100%
  • Induced Pluripotent Stem Cells 97%
  • Morphogenesis 86%
  • Marker 75%
  • Cell Marker 70%
  51 Citations (Scopus)

• Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species

  Hosono, K., Sasaki, T., Minoshima, S. & Shimizu, N., 2004 Sept 29, In: Gene. 340, 1, p. 31-43 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Centrosome 100%
  • Spindle Apparatus 99%
  • Genes 85%
  • Interphase 61%
  • Proteins 58%
  47 Citations (Scopus)

• Identification and characterization of a recessive missense mutation p.P277L in SERPINB7 in nagashima-type palmoplantar keratosis

  Shiohama, A., Sasaki, T., Sato, S., Sakabe, J. I., Ito, T., Isoda, H., Zenke, Y., Nakano, T., Maeda, T., Ishiko, A., Kabashima, K., Tokura, Y., Mitsuhashi, Y., Amagai, M. & Kubo, A., 2016 Jan, In: Journal of Investigative Dermatology. 136, 1, p. 325-328 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  13 Citations (Scopus)

• Identification of eight members of the Argonaute family in the human genome

  Sasaki, T., Shiohama, A., Minoshima, S. & Shimizu, N., 2003 Sept 1, In: Genomics. 82, 3, p. 323-330 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Human Genome 100%
  • Complementary DNA 25%
  • Ribonuclease III 23%
  • Stem Cells 23%
  • Maintenance 22%
  332 Citations (Scopus)

• Identification of factors contributing to phenotypic divergence via quantitative image analyses of autosomal recessive woolly hair/hypotrichosis with homozygous c.736T>A LIPH mutation

  Kinoshita-Ise, M., Kubo, A., Sasaki, T., Umegaki, N., Amagai, M. & Ohyama, M., 2017 Jan 1, In: British Journal of Dermatology. 176, 1, p. 138-144 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Autosomal Recessive Woolly Hair 100%
  • Hypotrichosis 76%
  • Hair 47%
  • Mutation 26%
  • Homozygote 8%
  13 Citations (Scopus)

• Identification of mutations in the prostaglandin transporter gene SLCO2A1 and its phenotype-genotype correlation in Japanese patients with pachydermoperiostosis

  Sasaki, T., Niizeki, H., Shimizu, A., Shiohama, A., Hirakiyama, A., Okuyama, T., Seki, A., Kabashima, K., Otsuka, A., Ishiko, A., Tanese, K., Miyakawa, S. I., Sakabe, J. I., Kuwahara, M., Amagai, M., Okano, H., Suematsu, M. & Kudo, J., 2012 Oct, In: Journal of Dermatological Science. 68, 1, p. 36-44 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Primary Hypertrophic Osteoarthropathy 100%
  • Prostaglandin 67%
  • Genetic Association Studies 62%
  • Prostaglandins 55%
  • Mutation 49%
  63 Citations (Scopus)

• Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway

  Yang, H., Sasaki, T., Minoshima, S. & Shimizu, N., 2007 Aug, In: Genomics. 90, 2, p. 249-260 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Monomeric GTP-Binding Proteins 100%
  • Proteins 31%
  • Signal Transduction 26%
  • trans-Golgi Network 23%
  • Northern Blotting 16%
  44 Citations (Scopus)

• Impact of Amyloid and Tau PET on Changes in Diagnosis and Patient Management

  Shimohama, S., Tezuka, T., Takahata, K., Bun, S., Tabuchi, H., Seki, M., Momota, Y., Suzuki, N., Morimoto, A., Iwabuchi, Y., Kubota, M., Yamamoto, Y., Sano, Y., Shikimoto, R., Funaki, K., Mimura, Y., Nishimoto, Y., Ueda, R., Jinzaki, M., Nakahara, J., & 2 othersMimura, M. & Ito, D., 2023 Jan 17, In: Neurology. 100, 3, p. E264-E274

  Research output: Contribution to journal › Article › peer-review

  • Amyloid 100%
  • Dementia 88%
  • Cognitive Dysfunction 57%
  • 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene 21%
  • Change Management 17%
  1 Citation (Scopus)

• Improvement in right lung atelectasis (middle lobe syndrome) following administration of low-dose roxithromycin

  Kawamura, M., Arai, Y. & Tani, M., 2001 Apr 12, In: Respiration. 68, 2, p. 210-214 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Middle Lobe Syndrome 100%
  • Roxithromycin 81%
  • Pulmonary Atelectasis 65%
  • Macrolides 31%
  • Lung 29%
  9 Citations (Scopus)

• Increased blood COASY DNA methylation levels a potential biomarker for early pathology of Alzheimer’s disease

  Kobayashi, N., Shinagawa, S., Niimura, H., Kida, H., Nagata, T., Tagai, K., Shimada, K., Oka, N., Shikimoto, R., Noda, Y., Nakajima, S., Mimura, M., Shigeta, M. & Kondo, K., 2020 Dec 1, In: Scientific reports. 10, 1, 12217.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Methylation 100%
  • Alzheimer Disease 78%
  • Biomarkers 65%
  • Pathology 64%
  • Methylation 30%
  8 Citations (Scopus)

• Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression

  Nishihara, K., Shiga, T., Nakamura, E., Akiyama, T., Sasaki, T., Suzuki, S., Ko, M. S. H., Tada, N., Okano, H. & Akamatsu, W., 2019 Feb 12, In: Stem cell reports. 12, 2, p. 305-318 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Induced Pluripotent Stem Cells 100%
  • Marker 77%
  • Pluripotent Stem Cells 51%
  • Fibroblast Growth Factor 4 36%
  • Protein 36%
  8 Citations (Scopus)

• Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR(+)THY-1(+) mesenchymal cells

  Veraitch, O., Mabuchi, Y., Matsuzaki, Y., Sasaki, T., Okuno, H., Tsukashima, A., Amagai, M., Okano, H. & Ohyama, M., 2017 Feb 21, In: Scientific reports. 7, 42777.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hair Follicle 100%
  • Induced Pluripotent Stem Cells 97%
  • Skin 47%
  • Hair 31%
  • minoxidil sulfate ester 20%
  33 Citations (Scopus)

• Inflammatory Linear Verrucous Epidermal Nevus with a Postzygotic GJA1 Mutation Is a Mosaic Erythrokeratodermia Variabilis et Progressiva

  Umegaki, N., Sasaki, T., Fujita, H., Aoki, S., Kameyama, K., Amagai, M., Seishima, M. & Kubo, A., 2017 Apr 1, In: Journal of Investigative Dermatology. 137, 4, p. 967-970 4 p.

  Research output: Contribution to journal › Article › peer-review
  11 Citations (Scopus)

• Junctional epidermolysis bullosa without pyloric atresia due to a homozygous missense mutation in ITGB4

  Yoshida, K., Sadamoto, M., Sasaki, T., Kubo, A. & Ishiko, A., 2018 Jan 1, (Accepted/In press) In: Journal of Dermatology.

  Research output: Contribution to journal › Article › peer-review
  2 Citations (Scopus)

• Lipoprotein metabolism in Japanese centenarians: Effects of apolipoprotein E polymorphism and nutritional status

  Arai, Y., Hirose, N., Nakazawa, S., Yamamura, K., Shimizu, K. I., Takayama, M., Ebihara, Y., Osono, Y. & Homma, S., 2001 Nov 22, In: Journal of the American Geriatrics Society. 49, 11, p. 1434-1441 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Aged, 80 and over 100%
  • Apolipoproteins E 87%
  • Nutritional Status 80%
  • Lipoproteins 77%
  • HDL Cholesterol 36%
  35 Citations (Scopus)

• Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: Oncogenic transformation with epithelial-mesenchymal transition

  Nori, S., Okada, Y., Nishimura, S., Sasaki, T., Itakura, G., Kobayashi, Y., Renault-Mihara, F., Shimizu, A., Koya, I., Yoshida, R., Kudoh, J., Koike, M., Uchiyama, Y., Ikeda, E., Toyama, Y., Nakamura, M. & Okano, H., 2015 Mar 10, In: Stem cell reports. 4, 3, p. 360-373 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Oncogenic Transformation 100%
  • Cord 67%
  • Induced Pluripotent Stem Cells 61%
  • Epithelial-Mesenchymal Transition 56%
  • Spinal Cord Injuries 52%
  147 Citations (Scopus)

• Mental health of Japanese psychiatrists: The relationship among level of occupational stress, satisfaction and depressive symptoms

  Koreki, A., Nakagawa, A., Abe, A., Ikeuchi, H., Okubo, J., Oguri, A., Orimo, K., Katayama, N., Sato, H., Shikimoto, R., Nishiyama, G., Nogami, W., Haki, K., Hayashi, T., Fukagawa, Y., Funaki, K., Matsuzawa, M., Matsumoto, A. & Mimura, M., 2015 Mar 26, In: BMC Research Notes. 8, 1, 96.

  Research output: Contribution to journal › Article › peer-review

  • Occupational Stress 100%
  • Communication 73%
  • Mental Health 63%
  • Psychiatry 60%
  • Depression 53%
  6 Citations (Scopus)

• MEPD: A resource for medaka gene expression patterns

  Henrich, T., Ramialison, M., Wittbrodt, B., Assouline, B., Bourrat, F., Berger, A., Himmelbauer, H., Sasaki, T., Shimizu, N., Westerfield, M., Kondoh, H. & Wittbrodt, J., 2005 Jul 15, In: Bioinformatics. 21, 14, p. 3195-3197 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oryzias 100%
  • Gene Expression 85%
  • Gene expression 74%
  • Resources 63%
  • Ontology 43%
  21 Citations (Scopus)

• Microbiota-Independent Spontaneous Dermatitis Associated with Increased Sebaceous Lipid Production in Tmem79-Deficient Mice

  Morimoto, A., Fukuda, K., Ito, Y., Tahara, U., Sasaki, T., Shiohama, A., Kawasaki, H., Kawakami, E., Naganuma, T., Arita, M., Sasaki, H., Koseki, H., Matsui, T. & Amagai, M., 2022 Nov, In: Journal of Investigative Dermatology. 142, 11, p. 2864-2872.e6

  Research output: Contribution to journal › Article › peer-review

  • Dermatitis 100%
  • Microbiota 90%
  • Fatty Acid 73%
  • Lipid 62%
  • Lipids 59%
  1 Citation (Scopus)

• Molecular cloning and expression analysis of a novel gene DGCR8 located in the DiGeorge syndrome chromosomal region

  Shiohama, A., Sasaki, T., Noda, S., Minoshima, S. & Shimizu, N., 2003 Apr 25, In: Biochemical and Biophysical Research Communications. 304, 1, p. 184-190 7 p.

  Research output: Contribution to journal › Article › peer-review

  • DiGeorge Syndrome 100%
  • Developmental 87%
  • Molecular Cloning 84%
  • Amino Acid Sequence 67%
  • Embryonic Structures 35%
  111 Citations (Scopus)

• Molecular cloning of a member of the facilitative glucose transporter gene family GLUT11 (SLC2A11) and identification of transcription variants

  Sasaki, T., Minoshima, S., Shiohama, A., Shintani, A., Shimizu, A., Asakawa, S., Kawasaki, K. & Shimizu, N., 2001 Dec 21, In: Biochemical and Biophysical Research Communications. 289, 5, p. 1218-1224 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Molecular Cloning 100%
  • Facilitative Glucose Transport Proteins 99%
  • Complementary DNA 89%
  • Exons 71%
  • Glucose 63%
  30 Citations (Scopus)

• Mouse models for spontaneous dermatitis due to impaired skin barrier formation

  Sasaki, T., Shiohama, A. & Amagai, M., 2014, In: Japanese Journal of Clinical Immunology. 37, 3, p. 160-165 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dermatitis 100%
  • Skin 50%
  • Tail 44%
  • Nonsense Codon 39%
  • filaggrin 32%
  2 Citations (Scopus)

• Myocyte enhancer factor 2 regulates expression of medaka Oryzias latipes fast skeletal myosin heavy chain genes in a temperature-dependent manner

  Liang, C. S., Ikeda, D., Kinoshita, S., Shimizu, A., Sasaki, T., Asakawa, S., Shimizu, N. & Watabe, S., 2008 Jan 15, In: Gene. 407, 1-2, p. 42-53 12 p.

  Research output: Contribution to journal › Article › peer-review

  • MEF2 Transcription Factors 100%
  • Oryzias 97%
  • Myosin Heavy Chains 79%
  • Temperature 47%
  • 5' Flanking Region 47%
  17 Citations (Scopus)

• Neurofibromatosis type 2 with mild Pierre-Robin sequence showing a heterozygous chromosome 22q12 microdeletion encompassing NF2 and MN1

  Saito, S., Ono, N., Sasaki, T., Aoki, S., Kosaki, K., Kuze, B., Nakabayashi, K., Amagai, M. & Kubo, A., 2022 Nov, In: Journal of Human Genetics. 67, 11, p. 675-678 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Pierre Robin Syndrome 100%
  • Neurofibromatosis 2 92%
  • Chromosomes 51%
  • Cleft Palate 41%
  • Glossoptosis 32%

• Nucleolar localization of DGCR8 and identification of eleven DGCR8-associated proteins

  Shiohama, A., Sasaki, T., Noda, S., Minoshima, S. & Shimizu, N., 2007 Dec 10, In: Experimental Cell Research. 313, 20, p. 4196-4207 12 p.

  Research output: Contribution to journal › Article › peer-review

  • nucleolin 100%
  • RNA 60%
  • Immunoprecipitation 42%
  • Proteins 32%
  • Immunoelectron Microscopy 26%
  86 Citations (Scopus)

• Nutritional intake by the oldest elderly Japanese Tokyo centenarian study 6

  Takeda, S., Noji, H., Hirose, N., Arai, Y., Yamamura, K., Shimizu, K., Homma, S., Ebihara, Y. & Takayama, M., 1998, In: Japanese Journal of Geriatrics. 35, 7, p. 548-558 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Aged, 80 and over 100%
  • Tokyo 97%
  • Elderly 55%
  • Edible Grain 16%
  • Eating 15%
  12 Citations (Scopus)

• Occupational complexity and late-life memory and reasoning abilities

  Ishioka, Y., Gondo, Y., Masui, Y., Nakagawa, T., Tabuchi, M., Ogawa, M., Kamide, K., Ikebe, K., Arai, Y., Ishizaki, T. & Takahashi, R., 2015, In: Shinrigaku Kenkyu. 86, 3, p. 219-229 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Memory 100%
  • Aptitude 93%
  • Occupations 54%
  • performance 52%
  • occupation 36%
  1 Citation (Scopus)

• Osteoporosis and sarcopenia are associated with each other and reduced IGF1 levels are a risk for both diseases in the very old elderly

  Hata, R., Miyamoto, K., Abe, Y., Sasaki, T., Oguma, Y., Tajima, T., Arai, Y., Matsumoto, M., Nakamura, M., Kanaji, A. & Miyamoto, T., 2023 Jan, In: Bone. 166, 116570.

  Research output: Contribution to journal › Article › peer-review

  • Sarcopenia 100%
  • Somatomedins 85%
  • Osteoporosis 71%
  • Elderly 54%
  • Long-Term Care 14%
  1 Citation (Scopus)

• Pathological characterization of pachydermia in pachydermoperiostosis

  Tanese, K., Niizeki, H., Seki, A., Otsuka, A., Kabashima, K., Kosaki, K., Kuwahara, M., Miyakawa, S. I., Miyasaka, M., Matsuoka, K., Okuyama, T., Shiohama, A., Sasaki, T., Kudoh, J., Amagai, M. & Ishiko, A., 2015 Jul 1, In: Journal of Dermatology. 42, 7, p. 710-714 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Primary Hypertrophic Osteoarthropathy 100%
  • Elastic Tissue 43%
  • Mucins 38%
  • Skin 32%
  • Edema 28%
  24 Citations (Scopus)

• Physical independence and mortality at the extreme limit of life span: Supercentenarians study in Japan

  Arai, Y., Inagaki, H., Takayama, M., Abe, Y., Saito, Y., Takebayashi, T., Gondo, Y. & Hirose, N., 2014 Apr 1, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 69, 4, p. 486-494 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Longevity 100%
  • Japan 92%
  • Aged, 80 and over 90%
  • Mortality 56%
  • Survival 41%
  38 Citations (Scopus)

• Plasma phospholipid n-3 polyunsaturated fatty acids and major depressive disorder in Japanese elderly: the Japan Public Health Center-based Prospective Study

  Hamazaki, K., Matsuoka, Y. J., Yamaji, T., Sawada, N., Mimura, M., Nozaki, S., Shikimoto, R. & Tsugane, S., 2021 Dec, In: Scientific reports. 11, 1, 4003.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Omega-3 Fatty Acids 100%
  • Major Depressive Disorder 94%
  • Phospholipids 81%
  • Japan 75%
  • Public Health 64%
  2 Citations (Scopus)

• Predictive factors associated with psychological distress of caregivers of people with dementia in Japan: A cross-sectional study

  Shikimoto, R., Sado, M., Ninomiya, A., Yoshimura, K., Ikeda, B., Baba, T. & Mimura, M., 2018 Aug 1, In: International Psychogeriatrics. 30, 8, p. 1089-1098 10 p.

  Research output: Contribution to journal › Article › peer-review

  • dementia 100%
  • cross-sectional study 99%
  • Psychological Distress 98%
  • caregiver 85%
  • Caregivers 85%
  14 Citations (Scopus)

• Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation

  Fujita, H., Sasaki, T., Miyamoto, T., Akutsu, S. N., Sato, S., Mori, T., Nakabayashi, K., Hata, K., Suzuki, H., Kosaki, K., Matsuura, S., Matsubara, Y., Amagai, M. & Kubo, A., 2020 Nov, In: Aging Cell. 19, 11, e13251.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • M Phase Cell Cycle Checkpoints 100%
  • Premature Aging 98%
  • Chromosomal Instability 91%
  • Aneuploidy 53%
  • Mutation 41%
  7 Citations (Scopus)

• Prognostic significance of heart rate variability in centenarians

  Shimizu, K., Arai, Y., Hirose, N., Yonemoto, T. & Wakida, Y., 2002 Feb 18, In: Clinical and Experimental Hypertension. 24, 1-2, p. 91-97 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Aged, 80 and over 100%
  • Heart Rate 59%
  • Dementia 45%
  • Mortality 27%
  • Activities of Daily Living 27%
  7 Citations (Scopus)

• Quantitative Assessment of the Retina Using OCT and Associations with Cognitive Function

  Ito, Y., Sasaki, M., Takahashi, H., Nozaki, S., Matsuguma, S., Motomura, K., Ui, R., Shikimoto, R., Kawasaki, R., Yuki, K., Sawada, N., Mimura, M., Tsubota, K. & Tsugane, S., 2020 Jan, In: Ophthalmology. 127, 1, p. 107-118 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Nerve Fibers 100%
  • Retina 88%
  • Cognition 80%
  • Ganglia 56%
  • Dementia 48%
  24 Citations (Scopus)

• Radiation hybrid maps of medaka chromosomes LG 12, 17, and 22

  Su, F., Osada, Y., Ekker, M., Chevrette, M., Shimizu, A., Asakawa, S., Shiohama, A., Sasaki, T., Shimizu, N., Yamanaka, T., Sasado, T., Mitani, H., Geisler, R., Kondoh, H. & Furutani-Seiki, M., 2007 Jun, In: DNA Research. 14, 3, p. 135-140 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Radiation Hybrid Mapping 100%
  • Oryzias 95%
  • Chromosomes, Human, Pair 12 87%
  • Clone Cells 11%
  • Bacterial Artificial Chromosomes 10%
  5 Citations (Scopus)

• Recurrent gastrointestinal perforation in a patient with Ehlers-Danlos syndrome due to tenascin-X deficiency

  Sakiyama, T., Kubo, A., Sasaki, T., Yamada, T., Yabe, N., Matsumoto, K. I. & Futei, Y., 2015 May 1, In: Journal of Dermatology. 42, 5, p. 511-514 4 p.

  Research output: Contribution to journal › Article › peer-review

  • tenascin X 100%
  • Ehlers-Danlos Syndrome 77%
  • Exome 66%
  • Genetic Heterogeneity 32%
  • Nonsense Codon 31%
  20 Citations (Scopus)

• Reproductive history and risk of cognitive impairment in Japanese women

  For the Japan Public Health Center-based Prospective Study Group, 2019 Oct, In: Maturitas. 128, p. 22-28 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Reproductive History 100%
  • Estrogen 86%
  • Cognitive Dysfunction 66%
  • Marker 23%
  • Reproduction 23%
  16 Citations (Scopus)

• Restoration of the intrinsic properties of human dermal papilla in vitro

  Ohyama, M., Kobayashi, T., Sasaki, T., Shimizu, A. & Amagai, M., 2012 Sept 1, In: Journal of Cell Science. 125, 17, p. 4114-4125 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Skin 100%
  • In Vitro Techniques 79%
  • Hair Follicle 28%
  • Genes 19%
  • Oximes 16%
  111 Citations (Scopus)

• Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression in medaka

  Negishi, T., Nagai, Y., Asaoka, Y., Ohno, M., Namae, M., Mitani, H., Sasaki, T., Shimizu, N., Terai, S., Sakaida, I., Kondoh, H., Katada, T., Furutani-Seiki, M. & Nishina, H., 2010 Mar, In: Hepatology. 51, 3, p. 1037-1045 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Oryzias 100%
  • Tretinoin 70%
  • Gene Expression 40%
  • Liver 35%
  • Zebrafish 13%
  27 Citations (Scopus)

• RNA Sequencing Analysis Reveals Interactions between Breast Cancer or Melanoma Cells and the Tissue Microenvironment during Brain Metastasis

  Sato, R., Nakano, T., Hosonaga, M., Sampetrean, O., Harigai, R., Sasaki, T., Koya, I., Okano, H., Kudoh, J., Saya, H. & Arima, Y., 2017, In: BioMed Research International. 2017, 8032910.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Intracardiac 100%
  • RNA Sequencing 91%
  • Cellular Microenvironment 69%
  • RNA Sequence Analysis 61%
  • Melanoma 45%
  23 Citations (Scopus)

• Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression

  Horio, E., Kadomatsu, T., Miyata, K., Arai, Y., Hosokawa, K., Doi, Y., Ninomiya, T., Horiguchi, H., Endo, M., Tabata, M., Tazume, H., Tian, Z., Takahashi, O., Terada, K., Takeya, M., Hao, H., Hirose, N., Minami, T., Suda, T., Kiyohara, Y., & 3 othersOgawa, H., Kaikita, K. & Oike, Y., 2014 Apr, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 34, 4, p. 790-800 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Angiopoietin-like Proteins 100%
  • Atherosclerosis 48%
  • Mouse Angptl2 protein 44%
  • Endothelial Cells 44%
  • Inflammation 35%
  110 Citations (Scopus)

• Role of TBX1 in human del22q11.2 syndrome

  Yagi, H., Furutani, Y., Hamada, H., Sasaki, T., Asakawa, S., Minoshima, S., Ichida, F., Joo, K., Kimura, M., Imamura, S. I., Kamatani, N., Momma, K., Takao, A., Nakazawa, M., Shimizu, N. & Matsuoka, R., 2003 Oct 25, In: Lancet. 362, 9393, p. 1366-1373 8 p.

  Research output: Contribution to journal › Article › peer-review

  • DiGeorge Syndrome 100%
  • Mutation 32%
  • Chromosome Deletion 18%
  • Phenotype 17%
  • Hypocalcemia 17%
  666 Citations (Scopus)

• Sequence analysis of filaggrin gene by novel shotgun method in Japanese atopic dermatitis

  Sasaki, T., Kudoh, J., Ebihara, T., Shiohama, A., Asakawa, S., Shimizu, A., Takayanagi, A., Dekio, I., Sadahira, C., Amagai, M. & Shimizu, N., 2008 Aug, In: Journal of Dermatological Science. 51, 2, p. 113-120 8 p.

  Research output: Contribution to journal › Article › peer-review

  • filaggrin 100%
  • Firearms 78%
  • Atopic Dermatitis 72%
  • Sequence Analysis 64%
  • Mutation 58%
  18 Citations (Scopus)