Clinical and Translational Research Center

Research Output 1985 2019

2019

Analysis of DLL3 and ASCL1 in Surgically Resected Small Cell Lung Cancer (HOT1702)

on behalf of Hokkaido Lung Cancer Clinical Study Group, 2019 Jan 1, In : Oncologist.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
delta protein
Neuroendocrine Cells
Antibodies

Comprehensive validation of liquid-based cytology specimens for next-generation sequencing in cancer genome analysis

Akahane, T., Yamaguchi, T., Kato, Y., Yokoyama, S., Hamada, T., Nishida, Y., Higashi, M., Nishihara, H., Suzuki, S., Ueno, S. & Tanimoto, A., 2019 Jun 1, In : PloS one. 14, 6, e0217724.

Research output: Contribution to journalArticle

Open Access
Cytology
cell biology
Cell Biology
Genes
Genome

Effectiveness of a genetic test panel designed for gynecological cancer: an exploratory study

Ida, K., Miyamoto, T., Higuchi, S., Takeuchi, H., Yamada, S., Ono, M., Nishihara, H. & Shiozawa, T., 2019 Jul 1, In : Medical Oncology. 36, 7, 62.

Research output: Contribution to journalArticle

Neoplasms
Paraffin
Formaldehyde
Cost-Benefit Analysis
Ions

Effect of FGF/FGFR pathway blocking on lung adenocarcinoma and its cancer-associated fibroblasts

Hegab, A. E., Ozaki, M., Kameyama, N., Gao, J., Kagawa, S., Yasuda, H., Soejima, K., Yin, Y., Guzy, R. D., Nakamura, Y., Ornitz, D. M. & Betsuyaku, T., 2019 Jan 1, In : Journal of Pathology.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Fibroblast Growth Factors
Neoplasms
Lung
Cancer-Associated Fibroblasts
2 Citations (Scopus)

Efficacy of afatinib or osimertinib plus cetuximab combination therapy for non-small-cell lung cancer with EGFR exon 20 insertion mutations

Hasegawa, H., Yasuda, H., Hamamoto, J., Masuzawa, K., Tani, T., Nukaga, S., Hirano, T., Kobayashi, K., Manabe, T., Terai, H., Ikemura, S., Kawada, I., Naoki, K. & Soejima, K., 2019 Jan 1, In : Lung Cancer. 127, p. 146-152 7 p.

Research output: Contribution to journalArticle

Insertional Mutagenesis
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Exons
Therapeutics
1 Citation (Scopus)

Epithelial-to-mesenchymal transition is a mechanism of ALK inhibitor resistance in lung cancer independent of ALK mutation status

Fukuda, K., Takeuchi, S., Arai, S., Katayama, R., Nanjo, S., Tanimoto, A., Nishiyama, A., Nakagawa, T., Taniguchi, H., Suzuki, T., Yamada, T., Nishihara, H., Ninomiya, H., Ishikawa, Y., Baba, S., Takeuchi, K., Horiike, A., Yanagitani, N., Nishio, M. & Yano, S., 2019 Apr 1, In : Cancer Research. 79, 7, p. 1658-1670 13 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Lung Neoplasms
Mutation
Histone Deacetylase Inhibitors
Neoplasms
Allelic Imbalance
Platinum
Prostatic Neoplasms
Mutation
Therapeutics

Japan Society of Clinical Oncology provisional clinical opinion for the diagnosis and use of immunotherapy in patients with deficient DNA mismatch repair tumors, cooperated by Japanese Society of Medical Oncology, First Edition

Mishima, S., Taniguchi, H., Akagi, K., Baba, E., Fujiwara, Y., Hirasawa, A., Ikeda, M., Maeda, O., Muro, K., Nishihara, H., Nishiyama, H., Takano, T., Tsuchihara, K., Yatabe, Y., Kodera, Y. & Yoshino, T., 2019 Jan 1, In : International Journal of Clinical Oncology.

Research output: Contribution to journalArticle

Open Access
DNA Repair-Deficiency Disorders
DNA Mismatch Repair
Medical Oncology
Immunotherapy
Japan

Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations

Ikemura, S., Yasuda, H., Matsumoto, S., Kamada, M., Hamamoto, J., Masuzawa, K., Kobayashi, K., Manabe, T., Arai, D., Nakachi, I., Kawada, I., Ishioka, K., Nakamura, M., Namkoong, H., Naoki, K., Ono, F., Araki, M., Kanada, R., Ma, B., Hayashi, Y. & 8 others, Mimaki, S., Yoh, K., Kobayashi, S. S., Kohno, T., Okuno, Y., Goto, K., Tsuchihara, K. & Soejima, K., 2019 May 14, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10025-10030 6 p.

Research output: Contribution to journalArticle

Open Access
Molecular Dynamics Simulation
Lung Neoplasms
Mutation
Pharmaceutical Preparations
Protein-Tyrosine Kinases

Pancreatic stellate cells derived from human pancreatic cancer demonstrate aberrant SPARC-dependent ECM remodeling in 3D engineered fibrotic tissue of clinically relevant thickness

Tanaka, H. Y., Kitahara, K., Sasaki, N., Nakao, N., Sato, K., Narita, H., Shimoda, H., Matsusaki, M., Nishihara, H., Masamune, A. & Kano, M. R., 2019 Feb 1, In : Biomaterials. 192, p. 355-367 13 p.

Research output: Contribution to journalArticle

Pancreatic Stellate Cells
Pancreatic Neoplasms
Extracellular Matrix
Cysteine
Tissue
8 Citations (Scopus)

Pathways of Progression From Intraductal Papillary Mucinous Neoplasm to Pancreatic Ductal Adenocarcinoma Based on Molecular Features

Omori, Y., Ono, Y., Tanino, M., Karasaki, H., Yamaguchi, H., Furukawa, T., Enomoto, K., Ueda, J., Sumi, A., Katayama, J., Muraki, M., Taniue, K., Takahashi, K., Ambo, Y., Shinohara, T., Nishihara, H., Sasajima, J., Maguchi, H., Mizukami, Y., Okumura, T. & 1 others, Tanaka, S., 2019 Feb 1, In : Gastroenterology. 156, 3, p. 647-661.e2

Research output: Contribution to journalArticle

Open Access
Pancreatic Neoplasms
Adenocarcinoma
Neoplasms
Mutation
Papillary Adenocarcinoma

Practical procedures for the integrated diagnosis of astrocytic and oligodendroglial tumors

The committee for molecular diagnosis of the Japan Society of Brain Tumor Pathology, 2019 Apr 25, In : Brain tumor pathology. 36, 2, p. 56-62 7 p.

Research output: Contribution to journalArticle

Central Nervous System Neoplasms
Neoplasms
Japan
Brain Neoplasms
Software Design
2018
1 Citation (Scopus)

Biochemical, metabolomic, and genetic analyses of dephospho coenzyme a kinase involved in coenzyme a biosynthesis in the human enteric parasite entamoeba histolytica

Nurkanto, A., Jeelani, G., Yamamoto, T., Hishiki, T., Naito, Y., Suematsu, M., Hashimoto, T. & Nozaki, T., 2018 Nov 30, In : Frontiers in Microbiology. 9, NOV, 2902.

Research output: Contribution to journalArticle

Entamoeba histolytica
Metabolomics
Coenzymes
Molecular Biology
Parasites
2 Citations (Scopus)

Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target

Nurkanto, A., Jeelani, G., Yamamoto, T., Naito, Y., Hishiki, T., Mori, M., Suematsu, M., Shiomi, K., Hashimoto, T. & Nozaki, T., 2018 Apr 1, In : International Journal for Parasitology: Drugs and Drug Resistance. 8, 1, p. 125-136 12 p.

Research output: Contribution to journalArticle

Entamoeba histolytica
Coenzyme A
Pharmaceutical Preparations
Enzymes
Amebiasis
1 Citation (Scopus)

Characterization of centriole duplication in human epidermis, Bowen's disease, and squamous cell carcinoma

Watanuki, S., Fujita, H., Koyama, K., Amagai, M. & Kubo, A., 2018 Jan 1, (Accepted/In press) In : Journal of Dermatological Science.

Research output: Contribution to journalArticle

Bowen's Disease
Centrioles
Epidermis
Squamous Cell Carcinoma
Cells
3 Citations (Scopus)

Comparison of detection methods of EGFR T790M mutations using plasma, serum, and tumor tissue in EGFR-TKI-resistant non-small cell lung cancer

Kobayashi, K., Naoki, K., Manabe, T., Masuzawa, K., Hasegawa, H., Yasuda, H., Kawada, I., Soejima, K. & Betsuyaku, T., 2018 Jun 6, In : OncoTargets and Therapy. 11, p. 3335-3343 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Biopsy
Mutation
Serum
Neoplasms
4 Citations (Scopus)

Development of a highly sensitive device for counting the number of disease-specific exosomes in human sera

Kabe, Y., Suematsu, M., Sakamoto, S., Hirai, M., Koike, I., Hishiki, T., Matsuda, A., Hasegawa, Y., Tsujita, K., Ono, M., Minegishi, N., Hozawa, A., Murakami, Y., Kubo, M., Itonaga, M. & Handa, H., 2018 Oct 1, In : Clinical Chemistry. 64, 10, p. 1463-1473 11 p.

Research output: Contribution to journalArticle

Exosomes
Equipment and Supplies
CD147 Antigens
Serum
Flow cytometry

Egfr-mutant non-small cell lung cancer accompanied by transient asymptomatic pulmonary opacities successfully treated with “stop-and-go” osimertinib

Kobayashi, K., Naoki, K., Kuroda, A., Yasuda, H., Kawada, I., Soejima, K. & Betsuyaku, T., 2018 Jan 1, In : Internal Medicine. 57, 7, p. 1007-1010 4 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung
Epidermal Growth Factor Receptor
Tomography
Interstitial Lung Diseases
2 Citations (Scopus)

Genetic mutation analysis of the malignant transformation of sinonasal inverted papilloma by targeted amplicon sequencing

Yasukawa, S., Kano, S., Hatakeyama, H., Nakamaru, Y., Takagi, D., Mizumachi, T., Suzuki, M., Suzuki, T., Nakazono, A., Tanaka, S., Nishihara, H. & Homma, A., 2018 Oct 1, In : International Journal of Clinical Oncology. 23, 5, p. 835-843 9 p.

Research output: Contribution to journalArticle

Inverted Papilloma
Mutation
Squamous Cell Carcinoma
Mutation Rate
APC Genes

Glomangiopericytoma of the Nasal Cavity with CTNNB1 p.S37C Mutation: A Case Report and Literature Review

Kono, M., Bandoh, N., Matsuoka, R., Goto, T., Akahane, T., Kato, Y., Nakano, H., Yamaguchi, T., Harabuchi, Y. & Nishihara, H., 2018 Jan 1, (Accepted/In press) In : Head and Neck Pathology.

Research output: Contribution to journalArticle

Open Access
Nasal Cavity
Mutation
Neoplasms
Paranasal Sinuses
Nasal Septum
5 Citations (Scopus)

Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: Evidence from fatty acid-binding protein-4 and-5 knockout mice

Umbarawan, Y., Syamsunarno, M. R. A. A., Koitabashi, N., Yamaguchi, A., Hanaoka, H., Hishiki, T., Nagahata-Naito, Y., Obinata, H., Sano, M., Sunaga, H., Matsui, H., Tsushima, Y., Suematsu, M., Kurabayashi, M. & Iso, T., 2018 Jul 1, In : Cardiovascular Research. 114, 8, p. 1132-1144 13 p.

Research output: Contribution to journalArticle

Fatty Acid-Binding Proteins
Constriction
Knockout Mice
Biomass
Pressure
10 Citations (Scopus)

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival

Shiota, M., Naya, M., Yamamoto, T., Hishiki, T., Tani, T., Takahashi, H., Kubo, A., Koike, D., Itoh, M., Ohmura, M., Kabe, Y., Sugiura, Y., Hiraoka, N., Morikawa, T., Takubo, K., Suina, K., Nagashima, H., Sampetrean, O., Nagano, O., Saya, H. & 3 others, Yamazoe, S., Watanabe, H. & Suematsu, M., 2018 Dec 1, In : Nature Communications. 9, 1, 1561.

Research output: Contribution to journalArticle

Raman Spectrum Analysis
Oxidants
Gold
Raman spectroscopy
tumors

GSTP1 rs1695 is associated with both hematological toxicity and prognosis of ovarian cancer treated with paclitaxel plus carboplatin combination chemotherapy: A comprehensive analysis using targeted resequencing of 100 pharmacogenes

Yoshihama, T., Fukunaga, K., Hirasawa, A., Nomura, H., Akahane, T., Kataoka, F., Yamagami, W., Aoki, D. & Mushiroda, T., 2018 Jul 1, In : Oncotarget. 9, 51, p. 29789-29800 12 p.

Research output: Contribution to journalArticle

Carboplatin
Paclitaxel
Combination Drug Therapy
Ovarian Neoplasms
Fallopian Tube Neoplasms
5 Citations (Scopus)

Intermittent exposure to cigarette smoke increases lung tumors and the severity of emphysema more than continuous exposure

Kameyama, N., Chubachi, S., Hegab, A. E., Yasuda, H., Kagawa, S., Tsutsumi, A., Fukunaga, K., Shimoda, M., Kanai, Y., Soejima, K. & Betsuyaku, T., 2018 Aug 1, In : American Journal of Respiratory Cell and Molecular Biology. 59, 2, p. 179-188 10 p.

Research output: Contribution to journalArticle

Emphysema
Smoke
Tobacco Products
Tumors
Lung
3 Citations (Scopus)

Mutations in bassoon in individuals with familial and sporadic progressive supranuclear palsy-like syndrome

Yabe, I., Yaguchi, H., Kato, Y., Miki, Y., Takahashi, H., Tanikawa, S., Shirai, S., Takahashi, I., Kimura, M., Hama, Y., Matsushima, M., Fujioka, S., Kano, T., Watanabe, M., Nakagawa, S., Kunieda, Y., Ikeda, Y., Hasegawa, M., Nishihara, H., Ohtsuka, T. & 5 others, Tanaka, S., Tsuboi, Y., Hatakeyama, S., Wakabayashi, K. & Sasaki, H., 2018 Dec 1, In : Scientific reports. 8, 1, 819.

Research output: Contribution to journalArticle

Open Access
Progressive Supranuclear Palsy
Pedigree
Mutation
Tauopathies
Missense Mutation
1 Citation (Scopus)

Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure

Umbarawan, Y., Syamsunarno, M. R. A. A., Koitabashi, N., Obinata, H., Yamaguchi, A., Hanaoka, H., Hishiki, T., Hayakawa, N., Sano, M., Sunaga, H., Matsui, H., Tsushima, Y., Suematsu, M., Kurabayashi, M. & Iso, T., 2018 Dec 1, In : Scientific Reports. 8, 1, 12035.

Research output: Contribution to journalArticle

Constriction
Energy Metabolism
Fatty Acids
Heart Failure
Pressure
2 Citations (Scopus)

Neuroprotective Role of Astroglia in Parkinson Disease by Reducing Oxidative Stress Through Dopamine-Induced Activation of Pentose-Phosphate Pathway

Mashima, K., Takahashi, S., Minami, K., Izawa, Y., Abe, T., Tsukada, N., Hishiki, T., Suematsu, M., Kajimura, M. & Suzuki, N., 2018 May 1, In : ASN Neuro. 10

Research output: Contribution to journalArticle

Pentose Phosphate Pathway
Astrocytes
Parkinson Disease
Dopamine
Oxidative Stress
2 Citations (Scopus)

Pharmacological and structural characterizations of naquotinib, a novel third-generation EGFR tyrosine kinase inhibitor, in EGFR-mutated non–small cell lung cancer

Hirano, T., Yasuda, H., Hamamoto, J., Nukaga, S., Masuzawa, K., Kawada, I., Naoki, K., Niimi, T., Mimasu, S., Sakagami, H., Soejima, K. & Betsuyaku, T., 2018 Apr 1, In : Molecular Cancer Therapeutics. 17, 4, p. 740-750 11 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Pharmacology
Exons

Prognostic Understanding at Diagnosis and Associated Factors in Patients with Advanced Lung Cancer and Their Caregivers

Sato, T., Soejima, K., Fujisawa, D., Takeuchi, M., Arai, D., Nakachi, I., Naoki, K., Kawada, I., Yasuda, H., Ishioka, K., Nukaga, S., Kobayashi, K., Masaki, K., Inoue, T., Hikima, K., Nakamura, M., Ohgino, K., Oyamada, Y., Funatsu, Y., Terashima, T. & 5 others, Miyao, N., Sayama, K., Saito, F., Sakamaki, F. & Betsuyaku, T., 2018 Jan 1, (Accepted/In press) In : Oncologist.

Research output: Contribution to journalArticle

Caregivers
Lung Neoplasms
Anxiety
Depression
Neoplasms

Prospective exosome-focused translational research for afatinib study of non-small cell lung cancer patients expressing EGFR (EXTRA study)

Okuma, Y., Morikawa, K., Tanaka, H., Yokoyama, T., Itani, H., Horiuchi, K., Nakagawa, H., Takahashi, N., Bessho, A., Soejima, K., Kishi, K., Togashi, A., Kanai, Y., Ueda, K., Horimoto, K., Matsutani, N. & Seki, N., 2018 Jan 1, (Accepted/In press) In : Thoracic Cancer.

Research output: Contribution to journalArticle

Exosomes
Translational Medical Research
Non-Small Cell Lung Carcinoma
Biomarkers
Protein-Tyrosine Kinases
6 Citations (Scopus)

Real-world Efficacy and Safety of Nivolumab for Advanced Non-Small-cell Lung Cancer: A Retrospective Multicenter Analysis

Kobayashi, K., Nakachi, I., Naoki, K., Satomi, R., Nakamura, M., Inoue, T., Tateno, H., Sakamaki, F., Sayama, K., Terashima, T., Koh, H., Abe, T., Nishino, M., Arai, D., Yasuda, H., Kawada, I., Soejima, K. & Betsuyaku, T., 2018 Jan 1, (Accepted/In press) In : Clinical Lung Cancer.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Disease-Free Survival
Safety
Mutation
Confidence Intervals

Rituximab therapy for refractory autoimmune bullous diseases: A multicenter, open-label, single-arm, phase 1/2 study on 10 Japanese patients

Kurihara, Y., Yamagami, J., Funakoshi, T., Ishii, M., Miyamoto, J., Fujio, Y., Kakuta, R., Tanikawa, A., Aoyama, Y., Iwatsuki, K., Ishii, N., Hashimoto, T., Nishie, W., Shimizu, H., Koyama, K. & Amagai, M., 2018 Jan 1, (Accepted/In press) In : Journal of Dermatology.

Research output: Contribution to journalArticle

Pemphigus
Autoimmune Diseases
Bullous Pemphigoid
Therapeutics
Infectious Arthritis

Secondary brain neoplasm after stereotactic radiosurgery in patients with metastatic non-small cell lung cancer

Nukaga, S., Naoki, K., Yasuda, H., Kawada, I., Ohara, K., Soejima, K. & Betsuyaku, T., 2018 Jan 1, In : Internal Medicine. 57, 16, p. 2383-2387 5 p.

Research output: Contribution to journalArticle

Radiosurgery
Non-Small Cell Lung Carcinoma
Brain Neoplasms
Radiation-Induced Neoplasms
Neoplasm Metastasis
3 Citations (Scopus)

Targeted next-generation sequencing of cancer-related genes in thyroid carcinoma: A single institution's experience

Bandoh, N., Akahane, T., Goto, T., Kono, M., Ichikawa, H., Sawada, T., Yamaguchi, T., Nakano, H., Kawase, Y., Kato, Y., Kamada, H., Harabuchi, Y., Shimizu, K. & Nishihara, H., 2018 Dec 1, In : Oncology Letters. 16, 6, p. 7278-7286 9 p.

Research output: Contribution to journalArticle

Open Access
Neoplasm Genes
Thyroid Neoplasms
Papillary Carcinoma
Mutation
Carcinoma
Quality of Life
Skin
Social Adjustment
Dermatology
Neoplasms
2 Citations (Scopus)

The FGF2 aptamer inhibits the growth of FGF2-FGFR pathway driven lung cancer cells

Hamamoto, J., Yasuda, H., Nonaka, Y., Fujiwara, M., Nakamura, Y., Soejima, K. & Betsuyaku, T., 2018 Jan 1, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Lung Neoplasms
Cells
Growth
Cell proliferation
3 Citations (Scopus)

Tumor associated macrophages support the growth of FGF9-induced lung adenocarcinoma by multiple mechanisms

Hegab, A. E., Ozaki, M., Kagawa, S., Hamamoto, J., Yasuda, H., Naoki, K., Soejima, K., Yin, Y., Kinoshita, T., Yaguchi, T., Kawakami, Y., Ornitz, D. M. & Betsuyaku, T., 2018 May 1, In : Lung Cancer. 119, p. 25-35 11 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Macrophages
Growth
Neoplasms
Adenocarcinoma of lung
1 Citation (Scopus)

Tumor budding and human chorionic gonadotropin-β expression correlate with unfavorable patient outcome in colorectal carcinoma

Konishi, Y., Kawamata, F., Nishihara, H., Homma, S., Kato, Y., Tsuda, M., Kohsaka, S., Einama, T., Liu, C., Yoshida, T., Nagatsu, A., Tanino, M., Tanaka, S., Kawamura, H., Kamiyama, T. & Taketomi, A., 2018 Jul 1, In : Medical Oncology. 35, 7, 104.

Research output: Contribution to journalArticle

Chorionic Gonadotropin
Colorectal Neoplasms
Epithelial-Mesenchymal Transition
Neoplasms
Molecular Targeted Therapy
2017
29 Citations (Scopus)

Amplification of EGFR wild-type alleles in non-small cell lung cancer cells confers acquired resistance to mutation-selective EGFR tyrosine kinase inhibitors

Nukaga, S., Yasuda, H., Tsuchihara, K., Hamamoto, J., Masuzawa, K., Kawada, I., Naoki, K., Matsumoto, S., Mimaki, S., Ikemura, S., Goto, K., Betsuyaku, T. & Soejima, K., 2017 Apr 15, In : Cancer Research. 77, 8, p. 2078-2089 12 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Alleles
Mutation
Lung Neoplasms
2 Citations (Scopus)

A prospective cohort study of patients with non-squamous non-small cell lung cancer treated with bevacizumab

Naoki, K., Takeda, Y., Soejima, K., Arai, D., Naka, G. O., Nagase, S., Arimura, K., Kanemura, T., Ohhira, T. & Ikeda, N., 2017 May 1, In : Oncology Letters. 13, 5, p. 3285-3290 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cohort Studies
Prospective Studies
Disease-Free Survival
Epidermal Growth Factor Receptor
7 Citations (Scopus)

Characterization of the efficacies of osimertinib and nazartinib against cells expressing clinically relevant epidermal growth factor receptor mutations

Masuzawa, K., Yasuda, H., Hamamoto, J., Nukaga, S., Hirano, T., Kawada, I., Naoki, K., Soejima, K. & Betsuyaku, T., 2017 Jan 1, In : Oncotarget. 8, 62, p. 105479-105491 13 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Mutation
Inhibitory Concentration 50
osimertinib
Exons
9 Citations (Scopus)

Clinical and pathological characteristics of EGFR mutation in operable early-stage lung adenocarcinoma

Yotsukura, M., Yasuda, H., Shigenobu, T., Kaseda, K., Masai, K., Hayashi, Y., Hishida, T., Ohtsuka, T., Naoki, K., Soejima, K., Betsuyaku, T. & Asamura, H., 2017 Jul 1, In : Lung Cancer. 109, p. 45-51 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Mutation
Neoplasms
Exons
Adenocarcinoma of lung
1 Citation (Scopus)

Clinical utility of a self-administered questionnaire for assessment of hereditary gynecologic cancer

Masuda, K., Hirasawa, A., Irie-Kunitomi, H., Akahane, T., Ueki, A., Kobayashi, Y., Yamagami, W., Nomura, H., Kataoka, F., Tominaga, E., Banno, K., Susumu, N. & Aoki, D., 2017 May 1, In : Japanese Journal of Clinical Oncology. 47, 5, p. 401-406 6 p., hyx019.

Research output: Contribution to journalArticle

Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms
Endometrial Neoplasms
Ovarian Neoplasms
Surveys and Questionnaires
3 Citations (Scopus)

Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung

Kuroda, A., Hegab, A. E., Jingtao, G., Yamashita, S., Hizawa, N., Sakamoto, T., Yamada, H., Suzuki, S., Ishii, M., Namkoong, H., Asakura, T., Ozaki, M., Yasuda, H., Hamamoto, J., Kagawa, S., Soejima, K. & Betsuyaku, T., 2017 Apr 21, In : Respiratory Research. 18, 1, 69.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Lung
Genes
Stem Cells
Transgenic Mice
2 Citations (Scopus)

Non-small cell lung cancer PC-9 cells exhibit increased sensitivity to gemcitabine and vinorelbine upon acquiring resistance to EGFR-tyrosine kinase inhibitors

Hamamoto, J., Yasuda, H., Aizawa, K., Nishino, M., Nukaga, S., Hirano, T., Kawada, I., Naoki, K., Betsuyaku, T. & Soejima, K., 2017, In : Oncology Letters. 14, 3, p. 3559-3565 7 p.

Research output: Contribution to journalArticle

gemcitabine
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Lung Neoplasms
10 Citations (Scopus)

Osimertinib for EGFR T790M mutation-positive non-small cell lung cancer

Soejima, K., Yasuda, H. & Hirano, T., 2017 Jan 2, In : Expert Review of Clinical Pharmacology. 10, 1, p. 31-38 8 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Mutation
Lung Neoplasms
13 Citations (Scopus)

Overcoming EGFR bypass signal-induced acquired resistance to ALK tyrosine kinase inhibitors in ALK-translocated lung cancer

Miyawaki, M., Yasuda, H., Tani, T., Hamamoto, J., Arai, D., Ishioka, K., Ohgino, K., Nukaga, S., Hirano, T., Kawada, I., Naoki, K., Hayashi, Y., Betsuyaku, T. & Soejima, K., 2017 Jan 1, In : Molecular Cancer Research. 15, 1, p. 106-114 9 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Lung Neoplasms
Gene Rearrangement
Non-Small Cell Lung Carcinoma
anaplastic lymphoma kinase
5 Citations (Scopus)

Prevalence of pathogenic germline variants detected by multigene sequencing in unselected Japanese patients with ovarian cancer

Hirasawa, A., Imoto, I., Naruto, T., Akahane, T., Yamagami, W., Nomura, H., Masuda, K., Susumu, N., Tsuda, H. & Aoki, D., 2017 Jan 1, In : Oncotarget. 8, 68, p. 112258-112267 10 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Genes
Carcinoma
DNA Mismatch Repair
Fallopian Tubes
2 Citations (Scopus)

Radiologic features of precancerous areas of the lungs in chronic obstructive pulmonary disease

Keio COPD Comorbidity Research Group & Naoki, K., 2017 May 30, In : International Journal of COPD. 12, p. 1613-1624 12 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Lung Neoplasms
Lung
Emphysema
Odds Ratio
6 Citations (Scopus)

Robust suppression of cardiac energy catabolism with marked accumulation of energy substrates during lipopolysaccharide-induced cardiac dysfunction in mice

Umbarawan, Y., Syamsunarno, M. R. A. A., Obinata, H., Yamaguchi, A., Sunaga, H., Matsui, H., Hishiki, T., Matsuura, T., Koitabashi, N., Obokata, M., Hanaoka, H., Haque, A., Kunimoto, F., Tsushima, Y., Suematsu, M., Kurabayashi, M. & Iso, T., 2017 Dec 1, In : Metabolism: Clinical and Experimental. 77, p. 47-57 11 p.

Research output: Contribution to journalArticle

Lipopolysaccharides
Glucose
Fatty Acids
Ketone Bodies
Injections