Clinical and Translational Research Center

Research Output 1985 2019

2019

Efficacy of afatinib or osimertinib plus cetuximab combination therapy for non-small-cell lung cancer with EGFR exon 20 insertion mutations

Hasegawa, H., Yasuda, H., Hamamoto, J., Masuzawa, K., Tani, T., Nukaga, S., Hirano, T., Kobayashi, K., Manabe, T., Terai, H., Ikemura, S., Kawada, I., Naoki, K. & Soejima, K., 2019 Jan 1, In : Lung Cancer. 127, p. 146-152 7 p.

Research output: Contribution to journalArticle

Insertional Mutagenesis
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Exons
Therapeutics
2018

Biochemical, metabolomic, and genetic analyses of dephospho coenzyme a kinase involved in coenzyme a biosynthesis in the human enteric parasite entamoeba histolytica

Nurkanto, A., Jeelani, G., Yamamoto, T., Hishiki, T., Naito, Y., Suematsu, M., Hashimoto, T. & Nozaki, T., 2018 Nov 30, In : Frontiers in Microbiology. 9, NOV, 2902.

Research output: Contribution to journalArticle

Entamoeba histolytica
Metabolomics
Coenzymes
Molecular Biology
Parasites
1 Citation (Scopus)

Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target

Nurkanto, A., Jeelani, G., Yamamoto, T., Naito, Y., Hishiki, T., Mori, M., Suematsu, M., Shiomi, K., Hashimoto, T. & Nozaki, T., 2018 Apr 1, In : International Journal for Parasitology: Drugs and Drug Resistance. 8, 1, p. 125-136 12 p.

Research output: Contribution to journalArticle

Entamoeba histolytica
Coenzyme A
Pharmaceutical Preparations
Enzymes
Amebiasis

Characterization of centriole duplication in human epidermis, Bowen's disease, and squamous cell carcinoma

Watanuki, S., Fujita, H., Koyama, K., Amagai, M. & Kubo, A., 2018 Jan 1, (Accepted/In press) In : Journal of Dermatological Science.

Research output: Contribution to journalArticle

Bowen's Disease
Centrioles
Epidermis
Squamous Cell Carcinoma
Cells
1 Citation (Scopus)

Comparison of detection methods of EGFR T790M mutations using plasma, serum, and tumor tissue in EGFR-TKI-resistant non-small cell lung cancer

Kobayashi, K., Naoki, K., Manabe, T., Masuzawa, K., Hasegawa, H., Yasuda, H., Kawada, I., Soejima, K. & Betsuyaku, T., 2018 Jun 6, In : OncoTargets and Therapy. 11, p. 3335-3343 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Biopsy
Mutation
Serum
Neoplasms
3 Citations (Scopus)

Development of a highly sensitive device for counting the number of disease-specific exosomes in human sera

Kabe, Y., Suematsu, M., Sakamoto, S., Hirai, M., Koike, I., Hishiki, T., Matsuda, A., Hasegawa, Y., Tsujita, K., Ono, M., Minegishi, N., Hozawa, A., Murakami, Y., Kubo, M., Itonaga, M. & Handa, H., 2018 Oct 1, In : Clinical Chemistry. 64, 10, p. 1463-1473 11 p.

Research output: Contribution to journalArticle

Exosomes
Equipment and Supplies
CD147 Antigens
Serum
Flow cytometry

Egfr-mutant non-small cell lung cancer accompanied by transient asymptomatic pulmonary opacities successfully treated with “stop-and-go” osimertinib

Kobayashi, K., Naoki, K., Kuroda, A., Yasuda, H., Kawada, I., Soejima, K. & Betsuyaku, T., 2018 Jan 1, In : Internal Medicine. 57, 7, p. 1007-1010 4 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung
Epidermal Growth Factor Receptor
Tomography
Interstitial Lung Diseases
3 Citations (Scopus)

Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: Evidence from fatty acid-binding protein-4 and-5 knockout mice

Umbarawan, Y., Syamsunarno, M. R. A. A., Koitabashi, N., Yamaguchi, A., Hanaoka, H., Hishiki, T., Nagahata-Naito, Y., Obinata, H., Sano, M., Sunaga, H., Matsui, H., Tsushima, Y., Suematsu, M., Kurabayashi, M. & Iso, T., 2018 Jul 1, In : Cardiovascular Research. 114, 8, p. 1132-1144 13 p.

Research output: Contribution to journalArticle

Fatty Acid-Binding Proteins
Constriction
Knockout Mice
Biomass
Pressure
9 Citations (Scopus)

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival

Shiota, M., Naya, M., Yamamoto, T., Hishiki, T., Tani, T., Takahashi, H., Kubo, A., Koike, D., Itoh, M., Ohmura, M., Kabe, Y., Sugiura, Y., Hiraoka, N., Morikawa, T., Takubo, K., Suina, K., Nagashima, H., Sampetrean, O., Nagano, O., Saya, H. & 3 othersYamazoe, S., Watanabe, H. & Suematsu, M., 2018 Dec 1, In : Nature Communications. 9, 1, 1561.

Research output: Contribution to journalArticle

Raman Spectrum Analysis
Oxidants
Gold
Raman spectroscopy
tumors
Carboplatin
Paclitaxel
Combination Drug Therapy
Ovarian Neoplasms
Fallopian Tube Neoplasms
3 Citations (Scopus)

Intermittent exposure to cigarette smoke increases lung tumors and the severity of emphysema more than continuous exposure

Kameyama, N., Chubachi, S., Hegab, A. E., Yasuda, H., Kagawa, S., Tsutsumi, A., Fukunaga, K., Shimoda, M., Kanai, Y., Soejima, K. & Betsuyaku, T., 2018 Aug 1, In : American Journal of Respiratory Cell and Molecular Biology. 59, 2, p. 179-188 10 p.

Research output: Contribution to journalArticle

Emphysema
Smoke
Tobacco Products
Tumors
Lung
1 Citation (Scopus)

Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure

Umbarawan, Y., Syamsunarno, M. R. A. A., Koitabashi, N., Obinata, H., Yamaguchi, A., Hanaoka, H., Hishiki, T., Hayakawa, N., Sano, M., Sunaga, H., Matsui, H., Tsushima, Y., Suematsu, M., Kurabayashi, M. & Iso, T., 2018 Dec 1, In : Scientific Reports. 8, 1, 12035.

Research output: Contribution to journalArticle

Constriction
Energy Metabolism
Fatty Acids
Heart Failure
Pressure
1 Citation (Scopus)

Neuroprotective Role of Astroglia in Parkinson Disease by Reducing Oxidative Stress Through Dopamine-Induced Activation of Pentose-Phosphate Pathway

Mashima, K., Takahashi, S., Minami, K., Izawa, Y., Abe, T., Tsukada, N., Hishiki, T., Suematsu, M., Kajimura, M. & Suzuki, N., 2018 May 1, In : ASN Neuro. 10

Research output: Contribution to journalArticle

Pentose Phosphate Pathway
Astrocytes
Parkinson Disease
Dopamine
Oxidative Stress
2 Citations (Scopus)

Pharmacological and structural characterizations of naquotinib, a novel third-generation EGFR tyrosine kinase inhibitor, in EGFR-mutated non–small cell lung cancer

Hirano, T., Yasuda, H., Hamamoto, J., Nukaga, S., Masuzawa, K., Kawada, I., Naoki, K., Niimi, T., Mimasu, S., Sakagami, H., Soejima, K. & Betsuyaku, T., 2018 Apr 1, In : Molecular Cancer Therapeutics. 17, 4, p. 740-750 11 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Pharmacology
Exons

Prognostic Understanding at Diagnosis and Associated Factors in Patients with Advanced Lung Cancer and Their Caregivers

Sato, T., Soejima, K., Fujisawa, D., Takeuchi, M., Arai, D., Nakachi, I., Naoki, K., Kawada, I., Yasuda, H., Ishioka, K., Nukaga, S., Kobayashi, K., Masaki, K., Inoue, T., Hikima, K., Nakamura, M., Ohgino, K., Oyamada, Y., Funatsu, Y., Terashima, T. & 5 othersMiyao, N., Sayama, K., Saito, F., Sakamaki, F. & Betsuyaku, T., 2018 Jan 1, (Accepted/In press) In : Oncologist.

Research output: Contribution to journalArticle

Caregivers
Lung Neoplasms
Anxiety
Depression
Neoplasms

Prospective exosome-focused translational research for afatinib study of non-small cell lung cancer patients expressing EGFR (EXTRA study)

Okuma, Y., Morikawa, K., Tanaka, H., Yokoyama, T., Itani, H., Horiuchi, K., Nakagawa, H., Takahashi, N., Bessho, A., Soejima, K., Kishi, K., Togashi, A., Kanai, Y., Ueda, K., Horimoto, K., Matsutani, N. & Seki, N., 2018 Jan 1, (Accepted/In press) In : Thoracic Cancer.

Research output: Contribution to journalArticle

Exosomes
Translational Medical Research
Non-Small Cell Lung Carcinoma
Biomarkers
Protein-Tyrosine Kinases
6 Citations (Scopus)

Real-world Efficacy and Safety of Nivolumab for Advanced Non-Small-cell Lung Cancer: A Retrospective Multicenter Analysis

Kobayashi, K., Nakachi, I., Naoki, K., Satomi, R., Nakamura, M., Inoue, T., Tateno, H., Sakamaki, F., Sayama, K., Terashima, T., Koh, H., Abe, T., Nishino, M., Arai, D., Yasuda, H., Kawada, I., Soejima, K. & Betsuyaku, T., 2018 Jan 1, (Accepted/In press) In : Clinical Lung Cancer.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Disease-Free Survival
Safety
Mutation
Confidence Intervals

Rituximab therapy for refractory autoimmune bullous diseases: A multicenter, open-label, single-arm, phase 1/2 study on 10 Japanese patients

Kurihara, Y., Yamagami, J., Funakoshi, T., Ishii, M., Miyamoto, J., Fujio, Y., Kakuta, R., Tanikawa, A., Aoyama, Y., Iwatsuki, K., Ishii, N., Hashimoto, T., Nishie, W., Shimizu, H., Koyama, K. & Amagai, M., 2018 Jan 1, (Accepted/In press) In : Journal of Dermatology.

Research output: Contribution to journalArticle

Pemphigus
Autoimmune Diseases
Bullous Pemphigoid
Therapeutics
Infectious Arthritis

Secondary brain neoplasm after stereotactic radiosurgery in patients with metastatic non-small cell lung cancer

Nukaga, S., Naoki, K., Yasuda, H., Kawada, I., Ohara, K., Soejima, K. & Betsuyaku, T., 2018 Jan 1, In : Internal Medicine. 57, 16, p. 2383-2387 5 p.

Research output: Contribution to journalArticle

Radiosurgery
Non-Small Cell Lung Carcinoma
Brain Neoplasms
Radiation-Induced Neoplasms
Neoplasm Metastasis
Quality of Life
Skin
Social Adjustment
Dermatology
Neoplasms
2 Citations (Scopus)

The FGF2 aptamer inhibits the growth of FGF2-FGFR pathway driven lung cancer cells

Hamamoto, J., Yasuda, H., Nonaka, Y., Fujiwara, M., Nakamura, Y., Soejima, K. & Betsuyaku, T., 2018 Jan 1, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Lung Neoplasms
Cells
Growth
Cell proliferation
2 Citations (Scopus)

Tumor associated macrophages support the growth of FGF9-induced lung adenocarcinoma by multiple mechanisms

Hegab, A. E., Ozaki, M., Kagawa, S., Hamamoto, J., Yasuda, H., Naoki, K., Soejima, K., Yin, Y., Kinoshita, T., Yaguchi, T., Kawakami, Y., Ornitz, D. M. & Betsuyaku, T., 2018 May 1, In : Lung Cancer. 119, p. 25-35 11 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Macrophages
Growth
Neoplasms
Adenocarcinoma of lung
2017
24 Citations (Scopus)

Amplification of EGFR wild-type alleles in non-small cell lung cancer cells confers acquired resistance to mutation-selective EGFR tyrosine kinase inhibitors

Nukaga, S., Yasuda, H., Tsuchihara, K., Hamamoto, J., Masuzawa, K., Kawada, I., Naoki, K., Matsumoto, S., Mimaki, S., Ikemura, S., Goto, K., Betsuyaku, T. & Soejima, K., 2017 Apr 15, In : Cancer Research. 77, 8, p. 2078-2089 12 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Alleles
Mutation
Lung Neoplasms
2 Citations (Scopus)

A prospective cohort study of patients with non-squamous non-small cell lung cancer treated with bevacizumab

Naoki, K., Takeda, Y., Soejima, K., Arai, D., Naka, G. O., Nagase, S., Arimura, K., Kanemura, T., Ohhira, T. & Ikeda, N., 2017 May 1, In : Oncology Letters. 13, 5, p. 3285-3290 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cohort Studies
Prospective Studies
Disease-Free Survival
Epidermal Growth Factor Receptor
4 Citations (Scopus)

Characterization of the efficacies of osimertinib and nazartinib against cells expressing clinically relevant epidermal growth factor receptor mutations

Masuzawa, K., Yasuda, H., Hamamoto, J., Nukaga, S., Hirano, T., Kawada, I., Naoki, K., Soejima, K. & Betsuyaku, T., 2017 Jan 1, In : Oncotarget. 8, 62, p. 105479-105491 13 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Mutation
Inhibitory Concentration 50
osimertinib
Exons
7 Citations (Scopus)

Clinical and pathological characteristics of EGFR mutation in operable early-stage lung adenocarcinoma

Yotsukura, M., Yasuda, H., Shigenobu, T., Kaseda, K., Masai, K., Hayashi, Y., Hishida, T., Ohtsuka, T., Naoki, K., Soejima, K., Betsuyaku, T. & Asamura, H., 2017 Jul 1, In : Lung Cancer. 109, p. 45-51 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Mutation
Neoplasms
Exons
Adenocarcinoma of lung
1 Citation (Scopus)

Clinical utility of a self-administered questionnaire for assessment of hereditary gynecologic cancer

Masuda, K., Hirasawa, A., Irie-Kunitomi, H., Akahane, T., Ueki, A., Kobayashi, Y., Yamagami, W., Nomura, H., Kataoka, F., Tominaga, E., Banno, K., Susumu, N. & Aoki, D., 2017 May 1, In : Japanese Journal of Clinical Oncology. 47, 5, p. 401-406 6 p., hyx019.

Research output: Contribution to journalArticle

Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms
Endometrial Neoplasms
Ovarian Neoplasms
Surveys and Questionnaires
2 Citations (Scopus)

Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung

Kuroda, A., Hegab, A. E., Jingtao, G., Yamashita, S., Hizawa, N., Sakamoto, T., Yamada, H., Suzuki, S., Ishii, M., Namkoong, H., Asakura, T., Ozaki, M., Yasuda, H., Hamamoto, J., Kagawa, S., Soejima, K. & Betsuyaku, T., 2017 Apr 21, In : Respiratory Research. 18, 1, 69.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Lung
Genes
Stem Cells
Transgenic Mice
2 Citations (Scopus)

Non-small cell lung cancer PC-9 cells exhibit increased sensitivity to gemcitabine and vinorelbine upon acquiring resistance to EGFR-tyrosine kinase inhibitors

Hamamoto, J., Yasuda, H., Aizawa, K., Nishino, M., Nukaga, S., Hirano, T., Kawada, I., Naoki, K., Betsuyaku, T. & Soejima, K., 2017, In : Oncology Letters. 14, 3, p. 3559-3565 7 p.

Research output: Contribution to journalArticle

gemcitabine
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Lung Neoplasms
8 Citations (Scopus)

Osimertinib for EGFR T790M mutation-positive non-small cell lung cancer

Soejima, K., Yasuda, H. & Hirano, T., 2017 Jan 2, In : Expert Review of Clinical Pharmacology. 10, 1, p. 31-38 8 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Mutation
Lung Neoplasms
11 Citations (Scopus)

Overcoming EGFR bypass signal-induced acquired resistance to ALK tyrosine kinase inhibitors in ALK-translocated lung cancer

Miyawaki, M., Yasuda, H., Tani, T., Hamamoto, J., Arai, D., Ishioka, K., Ohgino, K., Nukaga, S., Hirano, T., Kawada, I., Naoki, K., Hayashi, Y., Betsuyaku, T. & Soejima, K., 2017 Jan 1, In : Molecular Cancer Research. 15, 1, p. 106-114 9 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Lung Neoplasms
Gene Rearrangement
Non-Small Cell Lung Carcinoma
anaplastic lymphoma kinase
2 Citations (Scopus)

Prevalence of pathogenic germline variants detected by multigene sequencing in unselected Japanese patients with ovarian cancer

Hirasawa, A., Imoto, I., Naruto, T., Akahane, T., Yamagami, W., Nomura, H., Masuda, K., Susumu, N., Tsuda, H. & Aoki, D., 2017 Jan 1, In : Oncotarget. 8, 68, p. 112258-112267 10 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Genes
Carcinoma
DNA Mismatch Repair
Fallopian Tubes
2 Citations (Scopus)

Radiologic features of precancerous areas of the lungs in chronic obstructive pulmonary disease

Keio COPD Comorbidity Research Group & Naoki, K., 2017 May 30, In : International Journal of COPD. 12, p. 1613-1624 12 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Lung Neoplasms
Lung
Emphysema
Odds Ratio
6 Citations (Scopus)

Robust suppression of cardiac energy catabolism with marked accumulation of energy substrates during lipopolysaccharide-induced cardiac dysfunction in mice

Umbarawan, Y., Syamsunarno, M. R. A. A., Obinata, H., Yamaguchi, A., Sunaga, H., Matsui, H., Hishiki, T., Matsuura, T., Koitabashi, N., Obokata, M., Hanaoka, H., Haque, A., Kunimoto, F., Tsushima, Y., Suematsu, M., Kurabayashi, M. & Iso, T., 2017 Dec 1, In : Metabolism: Clinical and Experimental. 77, p. 47-57 11 p.

Research output: Contribution to journalArticle

Lipopolysaccharides
Glucose
Fatty Acids
Ketone Bodies
Injections
3 Citations (Scopus)

Targeting oxygen-sensing prolyl hydroxylase for metformin-associated lactic acidosis treatment

Toramaru, T., Suhara, T., Hayakawa, N., Nakamura, T., Kubo, A., Minamishima, S., Yamaguchi, K., Hishiki, T., Morisaki, H., Suematsu, M. & Minamishima, Y. A., 2017 Aug 1, In : Molecular and Cellular Biology. 37, 16, e00248-17.

Research output: Contribution to journalArticle

Prolyl Hydroxylases
Lactic Acidosis
Metformin
Oxygen
Prolyl-Hydroxylase Inhibitors
7 Citations (Scopus)

The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure

Ono, T., Kamimura, N., Matsuhashi, T., Nagai, T., Nishiyama, T., Endo, J., Hishiki, T., Nakanishi, T., Shimizu, N., Tanaka, H., Ohta, S., Suematsu, M., Ieda, M., Sano, M., Fukuda, K. & Kaneda, R., 2017 Jan 4, In : Scientific Reports. 7, 39752.

Research output: Contribution to journalArticle

Methyltransferases
Histones
Lysine
Heart Failure
Salts
2 Citations (Scopus)

UGT1A1 polymorphism as a prognostic indicator of stage I ovarian clear cell carcinoma patients treated with irinotecan

Yoshihama, T., Hirasawa, A., Nomura, H., Akahane, T., Nanki, Y., Yamagami, W., Kataoka, F., Tominaga, E., Susumu, N., Mushiroda, T. & Aoki, D., 2017 Feb 1, In : Japanese Journal of Clinical Oncology. 47, 2, p. 170-174 5 p.

Research output: Contribution to journalArticle

irinotecan
Carcinoma
Genotype
Disease-Free Survival
Recurrence
7 Citations (Scopus)

Variant CD44 expression is enriching for a cell population with cancer stem cell-like characteristics in human lung adenocarcinoma

Nishino, M., Ozaki, M., Hegab, A. E., Hamamoto, J., Kagawa, S., Arai, D., Yasuda, H., Naoki, K., Soejima, K., Saya, H. & Betsuyaku, T., 2017 Jun 1, In : Journal of Cancer. 8, 10, p. 1774-1785 12 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Aldehyde Dehydrogenase
Population
Cell Line
leucyl-alanyl-arginyl-leucyl-leucyl-threonine
2016
22 Citations (Scopus)

Activation of EGFR bypass signaling by TGFa overexpression induces acquired resistance to alectinib in ALK-translocated lung cancer cells

Tani, T., Yasuda, H., Hamamoto, J., Kuroda, A., Arai, D., Ishioka, K., Ohgino, K., Miyawaki, M., Kawada, I., Naoki, K., Hayashi, Y., Betsuyaku, T. & Soejima, K., 2016 Jan 1, In : Molecular Cancer Therapeutics. 15, 1, p. 162-171 10 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Non-Small Cell Lung Carcinoma
Gene Rearrangement
CH5424802
Receptor Protein-Tyrosine Kinases
14 Citations (Scopus)
Pentose Phosphate Pathway
Microglia
Lipopolysaccharides
Nitric Oxide
Toll-Like Receptor 4

Effects of laser in situ keratomileusis on mental health-related quality of life

Tounaka-Fujii, K., Yuki, K., Negishi, K., Toda, I., Abe, T., Koyama, K. & Tsubota, K., 2016 Sep 26, In : Clinical Ophthalmology. 10, p. 1859-1864 6 p.

Research output: Contribution to journalArticle

Laser In Situ Keratomileusis
Mental Health
Quality of Life
Health Surveys
Linear Models
37 Citations (Scopus)

Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells

Tohyama, S., Fujita, J., Hishiki, T., Matsuura, T., Hattori, F., Ohno, R., Kanazawa, H., Seki, T., Nakajima, K., Kishino, Y., Okada, M., Hirano, A., Kuroda, T., Yasuda, S., Sato, Y., Yuasa, S., Sano, M., Suematsu, M. & Fukuda, K., 2016 Apr 12, In : Cell Metabolism. 23, 4, p. 663-674 12 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Glutamine
Pyruvic Acid
Oxidative Phosphorylation
Adenosine Triphosphate
2015
11 Citations (Scopus)

Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart

Matsuhashi, T., Hishiki, T., Zhou, H., Ono, T., Kaneda, R., Iso, T., Yamaguchi, A., Endo, J., Katsumata, Y., Anzai, A., Yamamoto, T., Shirakawa, K., Yan, X., Shinmura, K., Suematsu, M., Fukuda, K. & Sano, M., 2015 May 1, In : Journal of Molecular and Cellular Cardiology. 82, p. 116-124 9 p.

Research output: Contribution to journalArticle

Pyruvic Acid
Epigenomics
Oxidoreductases
Histones
Citric Acid Cycle
6 Citations (Scopus)

A phase II study of biweekly paclitaxel and carboplatin in elderly patients with advanced non-small cell lung cancer

Soejima, K., Naoki, K., Ishioka, K., Nakamura, M., Nakatani, M., Kawada, I., Watanabe, H., Nakachi, I., Yasuda, H., Satomi, R., Nakayama, S., Yoda, S., Ikemura, S., Terai, H., Sato, T., Ohgino, K., Arai, D., Tani, T., Kuroda, A., Nishino, M. & 1 othersBetsuyaku, T., 2015, In : Cancer Chemotherapy and Pharmacology. 75, 3, p. 513-519 7 p.

Research output: Contribution to journalArticle

Carboplatin
Paclitaxel
Non-Small Cell Lung Carcinoma
Chemotherapy
Cells
2 Citations (Scopus)

A Phase II study of S-1 and irinotecan combination therapy in previously treated patients with advanced non-small cell lung cancer

Ikemura, S., Naoki, K., Yasuda, H., Kawada, I., Yoda, S., Terai, H., Sato, T., Ishioka, K., Arai, D., Ohgino, K., Kamata, H., Miyata, J., Kabata, H., Betsuyaku, T. & Soejima, K., 2015 Apr 1, In : Japanese Journal of Clinical Oncology. 45, 4, p. 356-361 6 p.

Research output: Contribution to journalArticle

irinotecan
Non-Small Cell Lung Carcinoma
Body Surface Area
Therapeutics
Disease-Free Survival
16 Citations (Scopus)

Characterization of the cell of origin and propagation potential of the fibroblast growth factor 9-induced mouse model of lung adenocarcinoma

Arai, D., Hegab, A. E., Soejima, K., Kuroda, A., Ishioka, K., Yasuda, H., Naoki, K., Kagawa, S., Hamamoto, J., Yin, Y., Ornitz, D. M. & Betsuyaku, T., 2015 Mar 1, In : Journal of Pathology. 235, 4, p. 593-605 13 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Neoplasms
Lung
Epithelium
Lung Neoplasms
2 Citations (Scopus)

Development of an S-1 dosage formula based on renal function by a prospective pharmacokinetic study

Booka, E., Imamura, C., Takeuchi, H., Hamamoto, Y., Gomi, D., Mizukami, T., Ichiyama, T., Tateishi, K., Takahashi, T., Kawakubo, H., Soejima, K., Boku, N., Tanigawara, Y. & Kitagawa, Y., 2015 Aug 25, (Accepted/In press) In : Gastric Cancer.

Research output: Contribution to journalArticle

Fluorouracil
Pharmacokinetics
Prospective Studies
Kidney
Area Under Curve
4 Citations (Scopus)

Dry pleurisy complicating solitary pulmonary nodules caused by Mycobacterium avium: A case report

Asakura, T., Ishii, M., Haraguchi, M., Kamiyama, I., Kohno, M., Sakamaki, H., Emoto, K., Hayashi, Y., Sugiura, H., Kawada, I., Soejima, K., Namkoong, H., Tasaka, S., Hasegawa, N. & Betsuyaku, T., 2015 Oct 26, (Accepted/In press) In : Journal of Medical Case Reports.

Research output: Contribution to journalArticle

Solitary Pulmonary Nodule
Mycobacterium avium
Mycobacterium avium Complex
Pleurisy
Chest Pain

Fatal fulminant pneumonia caused by methicillin-sensitive staphylococcus aureus negative for major high-virulence factors following influenza B virus infection

Masaki, K., Ishii, M., Anraku, M., Namkoong, H., Miyakawa, R., Nakajima, T., Fukunaga, K., Naoki, K., Tasaka, S., Soejima, K., Sayama, K., Sugita, K., Iwata, S., Cui, L., Hanaki, H., Hasegawa, N. & Betsuyaku, T., 2015 Jul 14, In : American Journal of Case Reports. 16, p. 454-458 5 p.

Research output: Contribution to journalArticle

Influenza B virus
Methicillin
Virulence Factors
Virus Diseases
Staphylococcus aureus
13 Citations (Scopus)

FOXD1 expression is associated with poor prognosis in non-small cell lung cancer

Nakayama, S., Soejima, K., Yasuda, H., Yoda, S., Satomi, R., Ikemura, S., Terai, H., Sato, T., Yamaguchi, N., Hamamoto, J., Arai, D., Ishioka, K., Ohgino, K., Naoki, K. & Betsuyaku, T., 2015 Jan 1, In : Anticancer Research. 35, 1, p. 261-268 8 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung Neoplasms
Cell Proliferation
Cell Line
Messenger RNA