Clinical and Translational Research Center

Research Output

2020

Aggressive prostate cancer with somatic loss of the homologous recombination repair gene FANCA: A case report

Hongo, H., Kosaka, T., Aimono, E., Nishihara, H. & Oya, M., 2020 Jan 13, In : Diagnostic Pathology. 15, 1, 5.

Research output: Contribution to journalArticle

Open Access

Cancer gene profiling explores the possible precision medicine for diffuse-type gastric adenocarcinoma

Ishikawa, M., Hayashi, H., Sakamoto, N., Tanaka, S. & Nishihara, H., 2020 Jan 1, In : Medical Oncology. 37, 1, 10.

Research output: Contribution to journalArticle

Detection of somatic TP53 mutation in surgically resected small-cell lung cancer by targeted exome sequencing: association with longer relapse-free survival

Yokouchi, H., Nishihara, H., Harada, T., Yamazaki, S., Kikuchi, H., Oizumi, S., Uramoto, H., Tanaka, F., Harada, M., Akie, K., Sugaya, F., Fujita, Y., Takamura, K., Kojima, T., Higuchi, M., Honjo, O., Minami, Y., Watanabe, N., Nishimura, M., Suzuki, H. & 2 others, Dosaka-Akita, H. & Isobe, H., 2020 Jul, In : Heliyon. 6, 7, e04439.

Research output: Contribution to journalArticle

Open Access

Establishment and characterization of a new malignant peritoneal mesothelioma cell line, KOG-1, from the ascitic fluid of a patient with pemetrexed chemotherapy resistance

Akahane, T., Hirasawa, A., Imoto, I., Okubo, A., Itoh, M., Nanki, Y., Yoshihama, T., Tominaga, E. & Aoki, D., 2020 Jan 1, In : Human Cell. 33, 1, p. 272-282 11 p.

Research output: Contribution to journalArticle

Excessive EP4 Signaling in Smooth Muscle Cells Induces Abdominal Aortic Aneurysm by Amplifying Inflammation

Hiromi, T., Yokoyama, U., Kurotaki, D., Mamun, A., Ishiwata, R., Ichikawa, Y., Nishihara, H., Umemura, M., Fujita, T., Yasuda, S., Minami, T., Goda, M., Uchida, K., Suzuki, S., Takeuchi, I., Masuda, M., Breyer, R. M., Tamura, T. & Ishikawa, Y., 2020, (Accepted/In press) In : Arteriosclerosis, Thrombosis, and Vascular Biology. p. 1559-1573 15 p.

Research output: Contribution to journalArticle

Open Access

Gefitinib alone versus gefitinib plus chemotherapy for non–small-cell lung cancer with mutated epidermal growth factor receptor: NEJ009 study

North-East Japan Study Group, 2020, In : Journal of Clinical Oncology. 38, 2, p. 115-123 9 p.

Research output: Contribution to journalArticle

Genetic profiling of patients with adenoid cystic carcinoma of the Bartholin's glands reveals potential new routes for targeted therapies: A case report

Nakamura, K., Aimono, E., Tanishima, S., Nomura, H., Imai, M., Hayashi, H. & Nishihara, H., 2020 May 28, In : Diagnostic Pathology. 15, 1, 64.

Research output: Contribution to journalArticle

Open Access

Intratumoral genomic heterogeneity may hinder precision medicine strategies in patients with serous ovarian carcinoma

Nakamura, K., Aimono, E., Tanishima, S., Imai, M., Nagatsuma, A. K., Hayashi, H., Yoshimura, Y., Nakayama, K., Kyo, S. & Nishihara, H., 2020 Apr, In : Diagnostics. 10, 4, 200.

Research output: Contribution to journalArticle

Open Access

Japan society of clinical oncology/Japanese society of medical oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors, cooperated by the Japanese society of pediatric hematology/oncology

Naito, Y., Mishima, S., Akagi, K., Igarashi, A., Ikeda, M., Okano, S., Kato, S., Takano, T., Tsuchihara, K., Terashima, K., Nishihara, H., Nishiyama, H., Hiyama, E., Hirasawa, A., Hosoi, H., Maeda, O., Yatabe, Y., Okamoto, W., Ono, S., Kajiyama, H. & 6 others, Nagashima, F., Hatanaka, Y., Miyachi, M., Kodera, Y., Yoshino, T. & Taniguchi, H., 2020 Mar 1, In : International Journal of Clinical Oncology. 25, 3, p. 403-417 15 p.

Research output: Contribution to journalArticle

Open Access

Japan Society of Clinical Oncology provisional clinical opinion for the diagnosis and use of immunotherapy in patients with deficient DNA mismatch repair tumors, cooperated by Japanese Society of Medical Oncology, First Edition

Mishima, S., Taniguchi, H., Akagi, K., Baba, E., Fujiwara, Y., Hirasawa, A., Ikeda, M., Maeda, O., Muro, K., Nishihara, H., Nishiyama, H., Takano, T., Tsuchihara, K., Yatabe, Y., Kodera, Y. & Yoshino, T., 2020 Feb 1, In : International Journal of Clinical Oncology. 25, 2, p. 217-239 23 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Key prognostic factors for EGFR-mutated non-adenocarcinoma lung cancer patients in the Japanese Joint Committee of Lung Cancer Registry Database

Kobayashi, K., Soejima, K., Fukunaga, K., Shintani, Y., Sekine, I., Shukuya, T., Takayama, K., Inoue, A., Okamoto, I., Kiura, K., Takahashi, K., Yamamoto, N., Takiguchi, Y., Miyaoka, E., Okumura, M. & Yoshino, I., 2020 Aug, In : Lung Cancer. 146, p. 236-243 8 p.

Research output: Contribution to journalArticle

Kimura Disease Presenting with Buccal Mass: A Case Report and Literature Review

Sato, R., Bandoh, N., Goto, T., Ichikawa, H., Uemura, A., Suzuki, S., Yamaguchi, T., Aimono, E., Nishihara, H., Katada, A. & Harabuchi, Y., 2020, (Accepted/In press) In : Head and Neck Pathology.

Research output: Contribution to journalArticle

Next-generation sequencing in residual liquid-based cytology specimens for cancer genome analysis

Yamaguchi, T., Akahane, T., Harada, O., Kato, Y., Aimono, E., Takei, H., Tasaki, T., Noguchi, H., Nishihara, H., Kamata, H. & Tanimoto, A., 2020, (Accepted/In press) In : Diagnostic Cytopathology.

Research output: Contribution to journalArticle

Osimertinib Overcomes Alectinib Resistance Caused by Amphiregulin in a Leptomeningeal Carcinomatosis Model of ALK-Rearranged Lung Cancer

Arai, S., Takeuchi, S., Fukuda, K., Taniguchi, H., Nishiyama, A., Tanimoto, A., Satouchi, M., Yamashita, K., Ohtsubo, K., Nanjo, S., Kumagai, T., Katayama, R., Nishio, M., Zheng, M. M., Wu, Y. L., Nishihara, H., Yamamoto, T., Nakada, M. & Yano, S., 2020 May, In : Journal of Thoracic Oncology. 15, 5, p. 752-765 14 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Resection of a desmoid-type fibromatosis with a CTNNB1 p.S45P mutation using a cervico-thoracic approach: A case report and literature review

Sato, R., Bandoh, N., Goto, T., Uemura, A., Inoue, N., Otomo, Y., Nakano, H., Yamaguchi, T., Kato, Y., Nishihara, H., Takei, H. & Harabuchi, Y., 2020, (Accepted/In press) In : Auris Nasus Larynx.

Research output: Contribution to journalArticle

Successful Retreatment Using Pembrolizumab for Non–small-cell Lung Cancer After Severe Immune-related Hepatitis: A Case Report

Kobayashi, K., Nakachi, I., Mitsuishi, A., Arai, D., Sakurai, K., Masaki, K., Chiyotani, A., Takahashi, H., Tahara, T. & Soejima, K., 2020 Jan, In : Clinical Lung Cancer. 21, 1, p. e30-e32

Research output: Contribution to journalArticle

The NOTCH–FOXM1 axis plays a key role in mitochondrial biogenesis in the induction of human stem cell memory–like CAR-T cells

Kondo, T., Ando, M., Nagai, N., Tomisato, W., Srirat, T., Liu, B., Mise-Omata, S., Ikeda, M., Chikuma, S., Nishimasu, H., Nureki, O., Ohmura, M., Hayakawa, N., Hishiki, T., Uchibori, R., Ozawa, K. & Yoshimura, A., 2020 Feb 1, In : Cancer Research. 80, 3, p. 471-483 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

がんゲノム医療における患者対応の経験から

Translated title of the contribution: Learning from my experience: Outpatient care for cancer multigene genomic testingAimono, E., Iguchi, A., Mochida, K., Imai, M., Hayashi, H. & Nishihara, H., 2020 May 1, In : Yakugaku Zasshi. 140, 5, p. 667-668 2 p.

Research output: Contribution to journalArticle

Open Access

ゲノム医療に求められるシステム構築と人材について

Translated title of the contribution: Required human and system resources for genomic medicineAimono, E. & Nishihara, H., 2020 May 1, In : Yakugaku Zasshi. 140, 5, p. 651-655 5 p.

Research output: Contribution to journalArticle

Open Access
2019
Open Access

Analysis of DLL3 and ASCL1 in Surgically Resected Small Cell Lung Cancer (HOT1702)

on behalf of Hokkaido Lung Cancer Clinical Study Group, 2019 Nov 1, In : Oncologist. 24, 11, p. e1172-e1179

Research output: Contribution to journalArticle

3 Citations (Scopus)

A phase II trial of induction of erlotinib followed by cytotoxic chemotherapy for EGFR mutation-positive non-squamous non-small cell lung cancer patients

Tani, T., Naoki, K., Yasuda, H., Arai, D., Ishioka, K., Ohgino, K., Yoda, S., Nakayama, S., Satomi, R., Terai, H., Ikemura, S., Sato, T. & Soejima, K., 2019 Nov 1, In : Cancer Chemotherapy and Pharmacology. 84, 5, p. 1065-1071 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Brain metastases in oncogene-driven non-small cell lung cancer

Nishino, M., Soejima, K. & Mitsudomi, T., 2019 Jan 1, In : Translational Lung Cancer Research. 8, p. S298-S307

Research output: Contribution to journalReview article

Comprehensive validation of liquid-based cytology specimens for next-generation sequencing in cancer genome analysis

Akahane, T., Yamaguchi, T., Kato, Y., Yokoyama, S., Hamada, T., Nishida, Y., Higashi, M., Nishihara, H., Suzuki, S., Ueno, S. & Tanimoto, A., 2019 Jun, In : PloS one. 14, 6, e0217724.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Effectiveness of a genetic test panel designed for gynecological cancer: an exploratory study

Ida, K., Miyamoto, T., Higuchi, S., Takeuchi, H., Yamada, S., Ono, M., Nishihara, H. & Shiozawa, T., 2019 Jul 1, In : Medical Oncology. 36, 7, 62.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Effect of FGF/FGFR pathway blocking on lung adenocarcinoma and its cancer-associated fibroblasts

Hegab, A. E., Ozaki, M., Kameyama, N., Gao, J., Kagawa, S., Yasuda, H., Soejima, K., Yin, Y., Guzy, R. D., Nakamura, Y., Ornitz, D. M. & Betsuyaku, T., 2019 Oct 1, In : Journal of Pathology. 249, 2, p. 193-205 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Efficacy of afatinib or osimertinib plus cetuximab combination therapy for non-small-cell lung cancer with EGFR exon 20 insertion mutations

Hasegawa, H., Yasuda, H., Hamamoto, J., Masuzawa, K., Tani, T., Nukaga, S., Hirano, T., Kobayashi, K., Manabe, T., Terai, H., Ikemura, S., Kawada, I., Naoki, K. & Soejima, K., 2019 Jan 1, In : Lung Cancer. 127, p. 146-152 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Epithelial-to-mesenchymal transition is a mechanism of ALK inhibitor resistance in lung cancer independent of ALK mutation status

Fukuda, K., Takeuchi, S., Arai, S., Katayama, R., Nanjo, S., Tanimoto, A., Nishiyama, A., Nakagawa, T., Taniguchi, H., Suzuki, T., Yamada, T., Nishihara, H., Ninomiya, H., Ishikawa, Y., Baba, S., Takeuchi, K., Horiike, A., Yanagitani, N., Nishio, M. & Yano, S., 2019 Apr 1, In : Cancer Research. 79, 7, p. 1658-1670 13 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Establishment of permutation for cancer risk estimation in the urothelium based on genome-wide DNA methylation analysis

Tsumura, K., Arai, E., Tian, Y., Shibuya, A., Nishihara, H., Yotani, T., Yamada, Y., Takahashi, Y., Maeshima, A. M., Fujimoto, H., Nakagawa, T., Kume, H., Homma, Y., Yoshida, T. & Kanai, Y., 2019 Nov 25, In : Carcinogenesis. 40, 11, p. 1308-1319 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
1 Citation (Scopus)

Long-lasting response to nivolumab for a patient with lynch syndrome-associated lung adenocarcinoma

Masuzawa, K., Asakura, T., Ikemura, S., Yasuda, H., Kawada, I., Takaoka, S., Hayashi, Y., Nakajima, T., Arai, M., Fukunaga, K. & Soejima, K., 2019, In : JCO Precision Oncology. 3, p. 74-78 5 p.

Research output: Contribution to journalArticle

Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations

Ikemura, S., Yasuda, H., Matsumoto, S., Kamada, M., Hamamoto, J., Masuzawa, K., Kobayashi, K., Manabe, T., Arai, D., Nakachi, I., Kawada, I., Ishioka, K., Nakamura, M., Namkoong, H., Naoki, K., Ono, F., Araki, M., Kanada, R., Ma, B., Hayashi, Y. & 8 others, Mimaki, S., Yoh, K., Kobayashi, S. S., Kohno, T., Okuno, Y., Goto, K., Tsuchihara, K. & Soejima, K., 2019 May 14, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10025-10030 6 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Monomer preference of EGFR tyrosine kinase inhibitors influences the synergistic efficacy of combination therapy with cetuximab

Oashi, A., Yasuda, H., Kobayashi, K., Tani, T., Hamamoto, J., Masuzawa, K., Manabe, T., Terai, H., Ikemura, S., Kawada, I., Naoki, K. & Soejima, K., 2019 Jan 1, In : Molecular cancer therapeutics. 18, 9, p. 1593-1601 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Multicenter study of zoledronic acid administration in non-small-cell lung cancer patients with bone metastasis: Thoracic oncology research group (TORG) 1017

Nakahara, Y., Hosomi, Y., Shibuya, M., Mitsufuji, H., Katagiri, M., Naoki, K., Soejima, K., Nogami, N., Nagase, S., Nishikawa, M., Minato, K., Takiguchi, Y., Seki, N., Yamada, K., Seto, T. & Okamoto, H., 2019 Oct, In : Molecular and Clinical Oncology. 11, 4, p. 349-353 5 p.

Research output: Contribution to journalArticle

Olaparib monotherapy for BRIP1-mutated high-grade serous endometrial cancer

Nakamura, K., Aimono, E., Tanishima, S., Imai, M., Nagatsuma, A. K., Hayashi, H., Yoshimura, Y., Nakayama, K., Kyo, S. & Nishihara, H., 2019 Jan 1, In : JCO Precision Oncology. 3, p. 283-290 8 p.

Research output: Contribution to journalArticle

Open Access

Pancreatic stellate cells derived from human pancreatic cancer demonstrate aberrant SPARC-dependent ECM remodeling in 3D engineered fibrotic tissue of clinically relevant thickness

Tanaka, H. Y., Kitahara, K., Sasaki, N., Nakao, N., Sato, K., Narita, H., Shimoda, H., Matsusaki, M., Nishihara, H., Masamune, A. & Kano, M. R., 2019 Feb, In : Biomaterials. 192, p. 355-367 13 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Pathways of Progression From Intraductal Papillary Mucinous Neoplasm to Pancreatic Ductal Adenocarcinoma Based on Molecular Features

Omori, Y., Ono, Y., Tanino, M., Karasaki, H., Yamaguchi, H., Furukawa, T., Enomoto, K., Ueda, J., Sumi, A., Katayama, J., Muraki, M., Taniue, K., Takahashi, K., Ambo, Y., Shinohara, T., Nishihara, H., Sasajima, J., Maguchi, H., Mizukami, Y., Okumura, T. & 1 others, Tanaka, S., 2019 Feb, In : Gastroenterology. 156, 3, p. 647-661.e2

Research output: Contribution to journalArticle

Open Access
25 Citations (Scopus)

Practical procedures for the integrated diagnosis of astrocytic and oligodendroglial tumors

The committee for molecular diagnosis of the Japan Society of Brain Tumor Pathology, 2019 Apr 25, In : Brain tumor pathology. 36, 2, p. 56-62 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Xanthine oxidase inhibitor ameliorates postischemic renal injury in mice by promoting resynthesis of adenine nucleotides

Fujii, K., Kubo, A., Miyashita, K., Sato, M., Hagiwara, A., Inoue, H., Ryuzaki, M., Tamaki, M., Hishiki, T., Hayakawa, N., Kabe, Y., Itoh, H. & Suematsu, M., 2019 Nov 14, In : JCI Insight. 4, 22, e124816.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Biochemical, metabolomic, and genetic analyses of dephospho coenzyme a kinase involved in coenzyme a biosynthesis in the human enteric parasite entamoeba histolytica

Nurkanto, A., Jeelani, G., Yamamoto, T., Hishiki, T., Naito, Y., Suematsu, M., Hashimoto, T. & Nozaki, T., 2018 Nov 30, In : Frontiers in Microbiology. 9, NOV, 2902.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target

Nurkanto, A., Jeelani, G., Yamamoto, T., Naito, Y., Hishiki, T., Mori, M., Suematsu, M., Shiomi, K., Hashimoto, T. & Nozaki, T., 2018 Apr, In : International Journal for Parasitology: Drugs and Drug Resistance. 8, 1, p. 125-136 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Characterization of centriole duplication in human epidermis, Bowen's disease, and squamous cell carcinoma

Watanuki, S., Fujita, H., Koyama, K., Amagai, M. & Kubo, A., 2018 Jan 1, (Accepted/In press) In : Journal of Dermatological Science.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Comparison of detection methods of EGFR T790M mutations using plasma, serum, and tumor tissue in EGFR-TKI-resistant non-small cell lung cancer

Kobayashi, K., Naoki, K., Manabe, T., Masuzawa, K., Hasegawa, H., Yasuda, H., Kawada, I., Soejima, K. & Betsuyaku, T., 2018 Jun 6, In : OncoTargets and Therapy. 11, p. 3335-3343 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Development of a highly sensitive device for counting the number of disease-specific exosomes in human sera

Kabe, Y., Suematsu, M., Sakamoto, S., Hirai, M., Koike, I., Hishiki, T., Matsuda, A., Hasegawa, Y., Tsujita, K., Ono, M., Minegishi, N., Hozawa, A., Murakami, Y., Kubo, M., Itonaga, M. & Handa, H., 2018 Oct, In : Clinical Chemistry. 64, 10, p. 1463-1473 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Effectiveness of indocyanine green fluorescence in endoscopic marking in gastric cancer surgery: A feasibility study for replacing India ink

Ono, H., Kusano, M., Nihei, M., Hayashi, H., Fukushima, H., Kawakami, M., Danjo, Y., Nagashima, K., Shimizu, Y., Kawamata, F., Honda, S., Shimamura, T. & Nishihara, H., 2018, In : Journal of Japanese Society of Gastroenterology. 115, 4, p. 385-393 9 p.

Research output: Contribution to journalArticle

Egfr-mutant non-small cell lung cancer accompanied by transient asymptomatic pulmonary opacities successfully treated with “stop-and-go” osimertinib

Kobayashi, K., Naoki, K., Kuroda, A., Yasuda, H., Kawada, I., Soejima, K. & Betsuyaku, T., 2018 Jan 1, In : Internal Medicine. 57, 7, p. 1007-1010 4 p.

Research output: Contribution to journalArticle

Genetic mutation analysis of the malignant transformation of sinonasal inverted papilloma by targeted amplicon sequencing

Yasukawa, S., Kano, S., Hatakeyama, H., Nakamaru, Y., Takagi, D., Mizumachi, T., Suzuki, M., Suzuki, T., Nakazono, A., Tanaka, S., Nishihara, H. & Homma, A., 2018 Oct 1, In : International Journal of Clinical Oncology. 23, 5, p. 835-843 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Genomic testing for pancreatic cancer in clinical practice as real-world evidence

Hayashi, H., Tanishima, S., Fujii, K., Mori, R., Okamura, Y., Yanagita, E., Matsuoka, R., Amano, T., Kinoshita, I., Komatsu, Y., Dosaka-Akita, H. & Nishihara, H., 2018 Sep, In : Pancreatology. 18, 6, p. 647-654 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Glomangiopericytoma of the Nasal Cavity with CTNNB1 p.S37C Mutation: A Case Report and Literature Review

Kono, M., Bandoh, N., Matsuoka, R., Goto, T., Akahane, T., Kato, Y., Nakano, H., Yamaguchi, T., Harabuchi, Y. & Nishihara, H., 2018 Jan 1, (Accepted/In press) In : Head and Neck Pathology.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: Evidence from fatty acid-binding protein-4 and-5 knockout mice

Umbarawan, Y., Syamsunarno, M. R. A. A., Koitabashi, N., Yamaguchi, A., Hanaoka, H., Hishiki, T., Nagahata-Naito, Y., Obinata, H., Sano, M., Sunaga, H., Matsui, H., Tsushima, Y., Suematsu, M., Kurabayashi, M. & Iso, T., 2018 Jul 1, In : Cardiovascular Research. 114, 8, p. 1132-1144 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)