Clinical and Translational Research Center – Research Output

2019

Efficacy of afatinib or osimertinib plus cetuximab combination therapy for non-small-cell lung cancer with EGFR exon 20 insertion mutations

Hasegawa, H., Yasuda, H., Hamamoto, J., Masuzawa, K., Tani, T., Nukaga, S., Hirano, T., Kobayashi, K., Manabe, T., Terai, H., Ikemura, S., Kawada, I., Naoki, K. & Soejima, K., 2019 Jan 1, In : Lung Cancer. 127, p. 146-152 7 p.

Research output: Contribution to journal › Article

Insertional Mutagenesis

Epidermal Growth Factor Receptor

Non-Small Cell Lung Carcinoma

Exons

Therapeutics

2018

Biochemical, metabolomic, and genetic analyses of dephospho coenzyme a kinase involved in coenzyme a biosynthesis in the human enteric parasite entamoeba histolytica

Nurkanto, A., Jeelani, G., Yamamoto, T., Hishiki, T., Naito, Y., Suematsu, M., Hashimoto, T. & Nozaki, T., 2018 Nov 30, In : Frontiers in Microbiology. 9, NOV, 2902.

Research output: Contribution to journal › Article

Entamoeba histolytica

Metabolomics

Coenzymes

Molecular Biology

Parasites

1 Citation (Scopus)

Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target

Nurkanto, A., Jeelani, G., Yamamoto, T., Naito, Y., Hishiki, T., Mori, M., Suematsu, M., Shiomi, K., Hashimoto, T. & Nozaki, T., 2018 Apr 1, In : International Journal for Parasitology: Drugs and Drug Resistance. 8, 1, p. 125-136 12 p.

Research output: Contribution to journal › Article

Entamoeba histolytica

Coenzyme A

Pharmaceutical Preparations

Enzymes

Amebiasis

Characterization of centriole duplication in human epidermis, Bowen's disease, and squamous cell carcinoma

Watanuki, S., Fujita, H., Koyama, K., Amagai, M. & Kubo, A., 2018 Jan 1, (Accepted/In press) In : Journal of Dermatological Science.

Research output: Contribution to journal › Article

Bowen's Disease

Centrioles

Epidermis

Squamous Cell Carcinoma

Cells

1 Citation (Scopus)

Comparison of detection methods of EGFR T790M mutations using plasma, serum, and tumor tissue in EGFR-TKI-resistant non-small cell lung cancer

Kobayashi, K., Naoki, K., Manabe, T., Masuzawa, K., Hasegawa, H., Yasuda, H., Kawada, I., Soejima, K. & Betsuyaku, T., 2018 Jun 6, In : OncoTargets and Therapy. 11, p. 3335-3343 9 p.

Research output: Contribution to journal › Article

Non-Small Cell Lung Carcinoma

Biopsy

Mutation

Serum

Neoplasms

3 Citations (Scopus)

Development of a highly sensitive device for counting the number of disease-specific exosomes in human sera

Kabe, Y., Suematsu, M., Sakamoto, S., Hirai, M., Koike, I., Hishiki, T., Matsuda, A., Hasegawa, Y., Tsujita, K., Ono, M., Minegishi, N., Hozawa, A., Murakami, Y., Kubo, M., Itonaga, M. & Handa, H., 2018 Oct 1, In : Clinical Chemistry. 64, 10, p. 1463-1473 11 p.

Research output: Contribution to journal › Article

Exosomes

Equipment and Supplies

CD147 Antigens

Serum

Flow cytometry

Egfr-mutant non-small cell lung cancer accompanied by transient asymptomatic pulmonary opacities successfully treated with “stop-and-go” osimertinib

Kobayashi, K., Naoki, K., Kuroda, A., Yasuda, H., Kawada, I., Soejima, K. & Betsuyaku, T., 2018 Jan 1, In : Internal Medicine. 57, 7, p. 1007-1010 4 p.

Research output: Contribution to journal › Article

Non-Small Cell Lung Carcinoma

Lung

Epidermal Growth Factor Receptor

Tomography

Interstitial Lung Diseases

3 Citations (Scopus)

Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: Evidence from fatty acid-binding protein-4 and-5 knockout mice

Umbarawan, Y., Syamsunarno, M. R. A. A., Koitabashi, N., Yamaguchi, A., Hanaoka, H., Hishiki, T., Nagahata-Naito, Y., Obinata, H., Sano, M., Sunaga, H., Matsui, H., Tsushima, Y., Suematsu, M., Kurabayashi, M. & Iso, T., 2018 Jul 1, In : Cardiovascular Research. 114, 8, p. 1132-1144 13 p.

Research output: Contribution to journal › Article

Fatty Acid-Binding Proteins

Constriction

Knockout Mice

Biomass

Pressure

9 Citations (Scopus)

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival

Shiota, M., Naya, M., Yamamoto, T., Hishiki, T., Tani, T., Takahashi, H., Kubo, A., Koike, D., Itoh, M., Ohmura, M., Kabe, Y., Sugiura, Y., Hiraoka, N., Morikawa, T., Takubo, K., Suina, K., Nagashima, H., Sampetrean, O., Nagano, O., Saya, H. & 3 othersYamazoe, S., Watanabe, H. & Suematsu, M., 2018 Dec 1, In : Nature Communications. 9, 1, 1561.

Research output: Contribution to journal › Article

Raman Spectrum Analysis

Oxidants

Gold

Raman spectroscopy

tumors

GSTP1 rs1695 is associated with both hematological toxicity and prognosis of ovarian cancer treated with paclitaxel plus carboplatin combination chemotherapy: A comprehensive analysis using targeted resequencing of 100 pharmacogenes

Yoshihama, T., Fukunaga, K., Hirasawa, A., Nomura, H., Akahane, T., Kataoka, F., Yamagami, W., Aoki, D. & Mushiroda, T., 2018 Jul 1, In : Oncotarget. 9, 51, p. 29789-29800 12 p.

Research output: Contribution to journal › Article

Carboplatin

Paclitaxel

Combination Drug Therapy

Ovarian Neoplasms

Fallopian Tube Neoplasms

3 Citations (Scopus)

Intermittent exposure to cigarette smoke increases lung tumors and the severity of emphysema more than continuous exposure

Kameyama, N., Chubachi, S., Hegab, A. E., Yasuda, H., Kagawa, S., Tsutsumi, A., Fukunaga, K., Shimoda, M., Kanai, Y., Soejima, K. & Betsuyaku, T., 2018 Aug 1, In : American Journal of Respiratory Cell and Molecular Biology. 59, 2, p. 179-188 10 p.

Research output: Contribution to journal › Article

Emphysema

Smoke

Tobacco Products

Tumors

Lung

1 Citation (Scopus)

Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure

Umbarawan, Y., Syamsunarno, M. R. A. A., Koitabashi, N., Obinata, H., Yamaguchi, A., Hanaoka, H., Hishiki, T., Hayakawa, N., Sano, M., Sunaga, H., Matsui, H., Tsushima, Y., Suematsu, M., Kurabayashi, M. & Iso, T., 2018 Dec 1, In : Scientific Reports. 8, 1, 12035.

Research output: Contribution to journal › Article

Constriction

Energy Metabolism

Fatty Acids

Heart Failure

Pressure

1 Citation (Scopus)

Neuroprotective Role of Astroglia in Parkinson Disease by Reducing Oxidative Stress Through Dopamine-Induced Activation of Pentose-Phosphate Pathway

Mashima, K., Takahashi, S., Minami, K., Izawa, Y., Abe, T., Tsukada, N., Hishiki, T., Suematsu, M., Kajimura, M. & Suzuki, N., 2018 May 1, In : ASN Neuro. 10

Research output: Contribution to journal › Article

Pentose Phosphate Pathway

Astrocytes

Parkinson Disease

Dopamine

Oxidative Stress

2 Citations (Scopus)

Pharmacological and structural characterizations of naquotinib, a novel third-generation EGFR tyrosine kinase inhibitor, in EGFR-mutated non–small cell lung cancer

Hirano, T., Yasuda, H., Hamamoto, J., Nukaga, S., Masuzawa, K., Kawada, I., Naoki, K., Niimi, T., Mimasu, S., Sakagami, H., Soejima, K. & Betsuyaku, T., 2018 Apr 1, In : Molecular Cancer Therapeutics. 17, 4, p. 740-750 11 p.

Research output: Contribution to journal › Article

Epidermal Growth Factor Receptor

Non-Small Cell Lung Carcinoma

Protein-Tyrosine Kinases

Pharmacology

Exons

Prognostic Understanding at Diagnosis and Associated Factors in Patients with Advanced Lung Cancer and Their Caregivers

Sato, T., Soejima, K., Fujisawa, D., Takeuchi, M., Arai, D., Nakachi, I., Naoki, K., Kawada, I., Yasuda, H., Ishioka, K., Nukaga, S., Kobayashi, K., Masaki, K., Inoue, T., Hikima, K., Nakamura, M., Ohgino, K., Oyamada, Y., Funatsu, Y., Terashima, T. & 5 othersMiyao, N., Sayama, K., Saito, F., Sakamaki, F. & Betsuyaku, T., 2018 Jan 1, (Accepted/In press) In : Oncologist.

Research output: Contribution to journal › Article

Caregivers

Lung Neoplasms

Anxiety

Depression

Neoplasms

Prospective exosome-focused translational research for afatinib study of non-small cell lung cancer patients expressing EGFR (EXTRA study)

Okuma, Y., Morikawa, K., Tanaka, H., Yokoyama, T., Itani, H., Horiuchi, K., Nakagawa, H., Takahashi, N., Bessho, A., Soejima, K., Kishi, K., Togashi, A., Kanai, Y., Ueda, K., Horimoto, K., Matsutani, N. & Seki, N., 2018 Jan 1, (Accepted/In press) In : Thoracic Cancer.

Research output: Contribution to journal › Article

Exosomes

Translational Medical Research

Non-Small Cell Lung Carcinoma

Biomarkers

Protein-Tyrosine Kinases

6 Citations (Scopus)

Real-world Efficacy and Safety of Nivolumab for Advanced Non-Small-cell Lung Cancer: A Retrospective Multicenter Analysis

Kobayashi, K., Nakachi, I., Naoki, K., Satomi, R., Nakamura, M., Inoue, T., Tateno, H., Sakamaki, F., Sayama, K., Terashima, T., Koh, H., Abe, T., Nishino, M., Arai, D., Yasuda, H., Kawada, I., Soejima, K. & Betsuyaku, T., 2018 Jan 1, (Accepted/In press) In : Clinical Lung Cancer.

Research output: Contribution to journal › Article

Non-Small Cell Lung Carcinoma

Disease-Free Survival

Safety

Mutation

Confidence Intervals

Rituximab therapy for refractory autoimmune bullous diseases: A multicenter, open-label, single-arm, phase 1/2 study on 10 Japanese patients

Kurihara, Y., Yamagami, J., Funakoshi, T., Ishii, M., Miyamoto, J., Fujio, Y., Kakuta, R., Tanikawa, A., Aoyama, Y., Iwatsuki, K., Ishii, N., Hashimoto, T., Nishie, W., Shimizu, H., Koyama, K. & Amagai, M., 2018 Jan 1, (Accepted/In press) In : Journal of Dermatology.

Research output: Contribution to journal › Article

Pemphigus

Autoimmune Diseases

Bullous Pemphigoid

Therapeutics

Infectious Arthritis

Secondary brain neoplasm after stereotactic radiosurgery in patients with metastatic non-small cell lung cancer

Nukaga, S., Naoki, K., Yasuda, H., Kawada, I., Ohara, K., Soejima, K. & Betsuyaku, T., 2018 Jan 1, In : Internal Medicine. 57, 16, p. 2383-2387 5 p.

Research output: Contribution to journal › Article

Radiosurgery

Non-Small Cell Lung Carcinoma

Brain Neoplasms

Radiation-Induced Neoplasms

Neoplasm Metastasis

Targeted Therapy-induced Facial Skin Toxicities: Impact on Quality of Life in Cancer Patients

Yagasaki, K., Komatsu, H., Soejima, K., Naoki, K., Kawada, I., Yasuda, H. & Hamamoto, Y., 2018 Apr 1, In : Asia-Pacific Journal of Oncology Nursing. 5, 2, p. 172-177 6 p.

Research output: Contribution to journal › Article

Quality of Life

Skin

Social Adjustment

Dermatology

Neoplasms

2 Citations (Scopus)

The FGF2 aptamer inhibits the growth of FGF2-FGFR pathway driven lung cancer cells

Hamamoto, J., Yasuda, H., Nonaka, Y., Fujiwara, M., Nakamura, Y., Soejima, K. & Betsuyaku, T., 2018 Jan 1, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journal › Article

Fibroblast Growth Factor 2

Lung Neoplasms

Cells

Growth

Cell proliferation

2 Citations (Scopus)

Tumor associated macrophages support the growth of FGF9-induced lung adenocarcinoma by multiple mechanisms

Hegab, A. E., Ozaki, M., Kagawa, S., Hamamoto, J., Yasuda, H., Naoki, K., Soejima, K., Yin, Y., Kinoshita, T., Yaguchi, T., Kawakami, Y., Ornitz, D. M. & Betsuyaku, T., 2018 May 1, In : Lung Cancer. 119, p. 25-35 11 p.

Research output: Contribution to journal › Article

Fibroblast Growth Factor 9

Macrophages

Growth

Neoplasms

Adenocarcinoma of lung

2017

24 Citations (Scopus)

Amplification of EGFR wild-type alleles in non-small cell lung cancer cells confers acquired resistance to mutation-selective EGFR tyrosine kinase inhibitors

Nukaga, S., Yasuda, H., Tsuchihara, K., Hamamoto, J., Masuzawa, K., Kawada, I., Naoki, K., Matsumoto, S., Mimaki, S., Ikemura, S., Goto, K., Betsuyaku, T. & Soejima, K., 2017 Apr 15, In : Cancer Research. 77, 8, p. 2078-2089 12 p.

Research output: Contribution to journal › Article

Non-Small Cell Lung Carcinoma

Protein-Tyrosine Kinases

Alleles

Mutation

Lung Neoplasms

2 Citations (Scopus)

A prospective cohort study of patients with non-squamous non-small cell lung cancer treated with bevacizumab

Naoki, K., Takeda, Y., Soejima, K., Arai, D., Naka, G. O., Nagase, S., Arimura, K., Kanemura, T., Ohhira, T. & Ikeda, N., 2017 May 1, In : Oncology Letters. 13, 5, p. 3285-3290 6 p.

Research output: Contribution to journal › Article

Non-Small Cell Lung Carcinoma

Cohort Studies

Prospective Studies

Disease-Free Survival

Epidermal Growth Factor Receptor

4 Citations (Scopus)

Characterization of the efficacies of osimertinib and nazartinib against cells expressing clinically relevant epidermal growth factor receptor mutations

Masuzawa, K., Yasuda, H., Hamamoto, J., Nukaga, S., Hirano, T., Kawada, I., Naoki, K., Soejima, K. & Betsuyaku, T., 2017 Jan 1, In : Oncotarget. 8, 62, p. 105479-105491 13 p.

Research output: Contribution to journal › Article

Epidermal Growth Factor Receptor

Mutation

Inhibitory Concentration 50

osimertinib

Exons

7 Citations (Scopus)

Clinical and pathological characteristics of EGFR mutation in operable early-stage lung adenocarcinoma

Yotsukura, M., Yasuda, H., Shigenobu, T., Kaseda, K., Masai, K., Hayashi, Y., Hishida, T., Ohtsuka, T., Naoki, K., Soejima, K., Betsuyaku, T. & Asamura, H., 2017 Jul 1, In : Lung Cancer. 109, p. 45-51 7 p.

Research output: Contribution to journal › Article

Epidermal Growth Factor Receptor

Mutation

Neoplasms

Exons

Adenocarcinoma of lung

1 Citation (Scopus)

Clinical utility of a self-administered questionnaire for assessment of hereditary gynecologic cancer

Masuda, K., Hirasawa, A., Irie-Kunitomi, H., Akahane, T., Ueki, A., Kobayashi, Y., Yamagami, W., Nomura, H., Kataoka, F., Tominaga, E., Banno, K., Susumu, N. & Aoki, D., 2017 May 1, In : Japanese Journal of Clinical Oncology. 47, 5, p. 401-406 6 p., hyx019.

Research output: Contribution to journal › Article

Neoplasms

Hereditary Nonpolyposis Colorectal Neoplasms

Endometrial Neoplasms

Ovarian Neoplasms

Surveys and Questionnaires

2 Citations (Scopus)

Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung

Kuroda, A., Hegab, A. E., Jingtao, G., Yamashita, S., Hizawa, N., Sakamoto, T., Yamada, H., Suzuki, S., Ishii, M., Namkoong, H., Asakura, T., Ozaki, M., Yasuda, H., Hamamoto, J., Kagawa, S., Soejima, K. & Betsuyaku, T., 2017 Apr 21, In : Respiratory Research. 18, 1, 69.

Research output: Contribution to journal › Article

Aldehyde Dehydrogenase

Lung

Genes

Stem Cells

Transgenic Mice

2 Citations (Scopus)

Non-small cell lung cancer PC-9 cells exhibit increased sensitivity to gemcitabine and vinorelbine upon acquiring resistance to EGFR-tyrosine kinase inhibitors

Hamamoto, J., Yasuda, H., Aizawa, K., Nishino, M., Nukaga, S., Hirano, T., Kawada, I., Naoki, K., Betsuyaku, T. & Soejima, K., 2017, In : Oncology Letters. 14, 3, p. 3559-3565 7 p.

Research output: Contribution to journal › Article

gemcitabine

Epidermal Growth Factor Receptor

Non-Small Cell Lung Carcinoma

Protein-Tyrosine Kinases

Lung Neoplasms

8 Citations (Scopus)

Osimertinib for EGFR T790M mutation-positive non-small cell lung cancer

Soejima, K., Yasuda, H. & Hirano, T., 2017 Jan 2, In : Expert Review of Clinical Pharmacology. 10, 1, p. 31-38 8 p.

Research output: Contribution to journal › Article

Epidermal Growth Factor Receptor

Non-Small Cell Lung Carcinoma

Protein-Tyrosine Kinases

Mutation

Lung Neoplasms

11 Citations (Scopus)

Overcoming EGFR bypass signal-induced acquired resistance to ALK tyrosine kinase inhibitors in ALK-translocated lung cancer

Miyawaki, M., Yasuda, H., Tani, T., Hamamoto, J., Arai, D., Ishioka, K., Ohgino, K., Nukaga, S., Hirano, T., Kawada, I., Naoki, K., Hayashi, Y., Betsuyaku, T. & Soejima, K., 2017 Jan 1, In : Molecular Cancer Research. 15, 1, p. 106-114 9 p.

Research output: Contribution to journal › Article

Protein-Tyrosine Kinases

Lung Neoplasms

Gene Rearrangement

Non-Small Cell Lung Carcinoma

anaplastic lymphoma kinase

2 Citations (Scopus)

Prevalence of pathogenic germline variants detected by multigene sequencing in unselected Japanese patients with ovarian cancer

Hirasawa, A., Imoto, I., Naruto, T., Akahane, T., Yamagami, W., Nomura, H., Masuda, K., Susumu, N., Tsuda, H. & Aoki, D., 2017 Jan 1, In : Oncotarget. 8, 68, p. 112258-112267 10 p.

Research output: Contribution to journal › Article

Ovarian Neoplasms

Genes

Carcinoma

DNA Mismatch Repair

Fallopian Tubes

2 Citations (Scopus)

Radiologic features of precancerous areas of the lungs in chronic obstructive pulmonary disease

Keio COPD Comorbidity Research Group & Naoki, K., 2017 May 30, In : International Journal of COPD. 12, p. 1613-1624 12 p.

Research output: Contribution to journal › Article

Chronic Obstructive Pulmonary Disease

Lung Neoplasms

Lung

Emphysema

Odds Ratio

6 Citations (Scopus)

Robust suppression of cardiac energy catabolism with marked accumulation of energy substrates during lipopolysaccharide-induced cardiac dysfunction in mice

Umbarawan, Y., Syamsunarno, M. R. A. A., Obinata, H., Yamaguchi, A., Sunaga, H., Matsui, H., Hishiki, T., Matsuura, T., Koitabashi, N., Obokata, M., Hanaoka, H., Haque, A., Kunimoto, F., Tsushima, Y., Suematsu, M., Kurabayashi, M. & Iso, T., 2017 Dec 1, In : Metabolism: Clinical and Experimental. 77, p. 47-57 11 p.

Research output: Contribution to journal › Article

Lipopolysaccharides

Glucose

Fatty Acids

Ketone Bodies

Injections

3 Citations (Scopus)

Targeting oxygen-sensing prolyl hydroxylase for metformin-associated lactic acidosis treatment

Toramaru, T., Suhara, T., Hayakawa, N., Nakamura, T., Kubo, A., Minamishima, S., Yamaguchi, K., Hishiki, T., Morisaki, H., Suematsu, M. & Minamishima, Y. A., 2017 Aug 1, In : Molecular and Cellular Biology. 37, 16, e00248-17.

Research output: Contribution to journal › Article

Prolyl Hydroxylases

Lactic Acidosis

Metformin

Oxygen

Prolyl-Hydroxylase Inhibitors

7 Citations (Scopus)

The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure

Ono, T., Kamimura, N., Matsuhashi, T., Nagai, T., Nishiyama, T., Endo, J., Hishiki, T., Nakanishi, T., Shimizu, N., Tanaka, H., Ohta, S., Suematsu, M., Ieda, M., Sano, M., Fukuda, K. & Kaneda, R., 2017 Jan 4, In : Scientific Reports. 7, 39752.

Research output: Contribution to journal › Article

Methyltransferases

Histones

Lysine

Heart Failure

Salts

2 Citations (Scopus)

UGT1A1 polymorphism as a prognostic indicator of stage I ovarian clear cell carcinoma patients treated with irinotecan

Yoshihama, T., Hirasawa, A., Nomura, H., Akahane, T., Nanki, Y., Yamagami, W., Kataoka, F., Tominaga, E., Susumu, N., Mushiroda, T. & Aoki, D., 2017 Feb 1, In : Japanese Journal of Clinical Oncology. 47, 2, p. 170-174 5 p.

Research output: Contribution to journal › Article

irinotecan

Carcinoma

Genotype

Disease-Free Survival

Recurrence

7 Citations (Scopus)

Variant CD44 expression is enriching for a cell population with cancer stem cell-like characteristics in human lung adenocarcinoma

Nishino, M., Ozaki, M., Hegab, A. E., Hamamoto, J., Kagawa, S., Arai, D., Yasuda, H., Naoki, K., Soejima, K., Saya, H. & Betsuyaku, T., 2017 Jun 1, In : Journal of Cancer. 8, 10, p. 1774-1785 12 p.

Research output: Contribution to journal › Article

Neoplastic Stem Cells

Aldehyde Dehydrogenase

Population

Cell Line

leucyl-alanyl-arginyl-leucyl-leucyl-threonine

2016

22 Citations (Scopus)

Activation of EGFR bypass signaling by TGFa overexpression induces acquired resistance to alectinib in ALK-translocated lung cancer cells

Tani, T., Yasuda, H., Hamamoto, J., Kuroda, A., Arai, D., Ishioka, K., Ohgino, K., Miyawaki, M., Kawada, I., Naoki, K., Hayashi, Y., Betsuyaku, T. & Soejima, K., 2016 Jan 1, In : Molecular Cancer Therapeutics. 15, 1, p. 162-171 10 p.

Research output: Contribution to journal › Article

Lung Neoplasms

Non-Small Cell Lung Carcinoma

Gene Rearrangement

CH5424802

Receptor Protein-Tyrosine Kinases

14 Citations (Scopus)

A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system

Iizumi, T., Takahashi, S., Mashima, K., Minami, K., Izawa, Y., Abe, T., Hishiki, T., Suematsu, M., Kajimura, M. & Suzuki, N., 2016 May 4, In : Journal of Neuroinflammation. 13, 1, 99.

Research output: Contribution to journal › Article

Pentose Phosphate Pathway

Microglia

Lipopolysaccharides

Nitric Oxide

Toll-Like Receptor 4

Effects of laser in situ keratomileusis on mental health-related quality of life

Tounaka-Fujii, K., Yuki, K., Negishi, K., Toda, I., Abe, T., Koyama, K. & Tsubota, K., 2016 Sep 26, In : Clinical Ophthalmology. 10, p. 1859-1864 6 p.

Research output: Contribution to journal › Article

Laser In Situ Keratomileusis

Mental Health

Quality of Life

Health Surveys

Linear Models

37 Citations (Scopus)

Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells

Tohyama, S., Fujita, J., Hishiki, T., Matsuura, T., Hattori, F., Ohno, R., Kanazawa, H., Seki, T., Nakajima, K., Kishino, Y., Okada, M., Hirano, A., Kuroda, T., Yasuda, S., Sato, Y., Yuasa, S., Sano, M., Suematsu, M. & Fukuda, K., 2016 Apr 12, In : Cell Metabolism. 23, 4, p. 663-674 12 p.

Research output: Contribution to journal › Article

Pluripotent Stem Cells

Glutamine

Pyruvic Acid

Oxidative Phosphorylation

Adenosine Triphosphate

2015

11 Citations (Scopus)

Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart

Matsuhashi, T., Hishiki, T., Zhou, H., Ono, T., Kaneda, R., Iso, T., Yamaguchi, A., Endo, J., Katsumata, Y., Anzai, A., Yamamoto, T., Shirakawa, K., Yan, X., Shinmura, K., Suematsu, M., Fukuda, K. & Sano, M., 2015 May 1, In : Journal of Molecular and Cellular Cardiology. 82, p. 116-124 9 p.

Research output: Contribution to journal › Article

Pyruvic Acid

Epigenomics

Oxidoreductases

Histones

Citric Acid Cycle

6 Citations (Scopus)

A phase II study of biweekly paclitaxel and carboplatin in elderly patients with advanced non-small cell lung cancer

Soejima, K., Naoki, K., Ishioka, K., Nakamura, M., Nakatani, M., Kawada, I., Watanabe, H., Nakachi, I., Yasuda, H., Satomi, R., Nakayama, S., Yoda, S., Ikemura, S., Terai, H., Sato, T., Ohgino, K., Arai, D., Tani, T., Kuroda, A., Nishino, M. & 1 othersBetsuyaku, T., 2015, In : Cancer Chemotherapy and Pharmacology. 75, 3, p. 513-519 7 p.

Research output: Contribution to journal › Article

Carboplatin

Paclitaxel

Non-Small Cell Lung Carcinoma

Chemotherapy

Cells

2 Citations (Scopus)

A Phase II study of S-1 and irinotecan combination therapy in previously treated patients with advanced non-small cell lung cancer

Ikemura, S., Naoki, K., Yasuda, H., Kawada, I., Yoda, S., Terai, H., Sato, T., Ishioka, K., Arai, D., Ohgino, K., Kamata, H., Miyata, J., Kabata, H., Betsuyaku, T. & Soejima, K., 2015 Apr 1, In : Japanese Journal of Clinical Oncology. 45, 4, p. 356-361 6 p.

Research output: Contribution to journal › Article

irinotecan

Non-Small Cell Lung Carcinoma

Body Surface Area

Therapeutics

Disease-Free Survival

16 Citations (Scopus)

Characterization of the cell of origin and propagation potential of the fibroblast growth factor 9-induced mouse model of lung adenocarcinoma

Arai, D., Hegab, A. E., Soejima, K., Kuroda, A., Ishioka, K., Yasuda, H., Naoki, K., Kagawa, S., Hamamoto, J., Yin, Y., Ornitz, D. M. & Betsuyaku, T., 2015 Mar 1, In : Journal of Pathology. 235, 4, p. 593-605 13 p.

Research output: Contribution to journal › Article

Fibroblast Growth Factor 9

Neoplasms

Lung

Epithelium

Lung Neoplasms

2 Citations (Scopus)

Development of an S-1 dosage formula based on renal function by a prospective pharmacokinetic study

Booka, E., Imamura, C., Takeuchi, H., Hamamoto, Y., Gomi, D., Mizukami, T., Ichiyama, T., Tateishi, K., Takahashi, T., Kawakubo, H., Soejima, K., Boku, N., Tanigawara, Y. & Kitagawa, Y., 2015 Aug 25, (Accepted/In press) In : Gastric Cancer.

Research output: Contribution to journal › Article

Fluorouracil

Pharmacokinetics

Prospective Studies

Kidney

Area Under Curve

4 Citations (Scopus)

Dry pleurisy complicating solitary pulmonary nodules caused by Mycobacterium avium: A case report

Asakura, T., Ishii, M., Haraguchi, M., Kamiyama, I., Kohno, M., Sakamaki, H., Emoto, K., Hayashi, Y., Sugiura, H., Kawada, I., Soejima, K., Namkoong, H., Tasaka, S., Hasegawa, N. & Betsuyaku, T., 2015 Oct 26, (Accepted/In press) In : Journal of Medical Case Reports.

Research output: Contribution to journal › Article

Solitary Pulmonary Nodule

Mycobacterium avium

Mycobacterium avium Complex

Pleurisy

Chest Pain

Fatal fulminant pneumonia caused by methicillin-sensitive staphylococcus aureus negative for major high-virulence factors following influenza B virus infection

Masaki, K., Ishii, M., Anraku, M., Namkoong, H., Miyakawa, R., Nakajima, T., Fukunaga, K., Naoki, K., Tasaka, S., Soejima, K., Sayama, K., Sugita, K., Iwata, S., Cui, L., Hanaki, H., Hasegawa, N. & Betsuyaku, T., 2015 Jul 14, In : American Journal of Case Reports. 16, p. 454-458 5 p.

Research output: Contribution to journal › Article

Influenza B virus

Methicillin

Virulence Factors

Virus Diseases

Staphylococcus aureus

13 Citations (Scopus)

FOXD1 expression is associated with poor prognosis in non-small cell lung cancer

Nakayama, S., Soejima, K., Yasuda, H., Yoda, S., Satomi, R., Ikemura, S., Terai, H., Sato, T., Yamaguchi, N., Hamamoto, J., Arai, D., Ishioka, K., Ohgino, K., Naoki, K. & Betsuyaku, T., 2015 Jan 1, In : Anticancer Research. 35, 1, p. 261-268 8 p.

Research output: Contribution to journal › Article

Non-Small Cell Lung Carcinoma

Lung Neoplasms

Cell Proliferation

Cell Line

Messenger RNA