Clinical and Translational Research Center

Research output

Research output per year 1985 2021

• 292 Article
• 7 Review article
• 2 Conference contribution
• 2 Comment/debate
• 4 More
  • 2 Letter
  • 2 Short survey

Research output per year

Research output per year

Search results

• 2021

  Biglycan, tumor endothelial cell secreting proteoglycan, as possible biomarker for lung cancer

  Morimoto, H., Hida, Y., Maishi, N., Nishihara, H., Hatanaka, Y., Li, C., Matsuno, Y., Nakamura, T., Hirano, S. & Hida, K., 2021, (Accepted/In press) In: Thoracic Cancer.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Biglycan
  • Proteoglycans
  • Lung Neoplasms
  • Endothelial Cells
  • Biomarkers

• Comparative performance analysis of interventional devices for the treatment of ischemic disease in below-the-knee lesions: a systematic review and meta-analysis

  Matsuoka, E. K., Hasebe, T., Ishii, R., Miyazaki, N., Soejima, K. & Iwasaki, K., 2021, (Accepted/In press) In: Cardiovascular Intervention and Therapeutics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Drug-Eluting Stents
  • Knee
  • Meta-Analysis
  • Systematic Reviews
  • Equipment and Supplies

• Estimating copy number using next-generation sequencing to determine ERBB2 amplification status

  Nakamura, K., Aimono, E., Oba, J., Hayashi, H., Tanishima, S., Hayashida, T., Chiyoda, T., Kosaka, T., Hishida, T., Kawakubo, H., Kitago, M., Okabayashi, K., Funakoshi, T., Okita, H., Ikeda, S., Takaishi, H. & Nishihara, H., 2021 Apr, In: Medical Oncology. 38, 4, 36.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fluorescence In Situ Hybridization
  • Immunohistochemistry
  • Breast Neoplasms
  • TYK2 Kinase
  • ErbB-2 Receptor

• Genetic profiling of malignant melanoma arising from an ovarian mature cystic teratoma: A case report

  Nakamura, K., Aimono, E., Takamatsu, R., Tanishima, S., Tohyama, T., Sasano, K., Sakuma, H. & Nishihara, H., 2021 Mar 1, In: International journal of molecular sciences. 22, 5, p. 1-7 7 p., 2436.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Teratoma
  • Tumors
  • tumors
  • Genes
  • Melanoma

• 肺癌におけるトランスレーショナルリサーチの現状と日本のアカデミアにおけるトランスレーショナルリサーチの展望と課題

  Soejima, K., 2021, In: Japanese Journal of Lung Cancer. 60, 4, p. 305-313 9 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Translational Medical Research
  • Japan
  • Lung Neoplasms
  • Seeds
  • Research Support
• 2020

  2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche

  Koike, N., Kota, R., Naito, Y., Hayakawa, N., Matsuura, T., Hishiki, T., Onishi, N., Fukada, J., Suematsu, M., Shigematsu, N., Saya, H. & Sampetrean, O., 2020 Dec 1, In: Communications biology. 3, 1, 450.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • azomycin
  • nitroimidazoles
  • Stem cells
  • doranidazole
  • glioma

• Adoptive transfer of zoledronate-expanded autologous V 39Vδ 2 T-cells in patients with treatment-refractory non-small-cell lung cancer: A multicenter, open-label, single-arm, phase 2 study

  Kakimi, K., Matsushita, H., Masuzawa, K., Karasaki, T., Kobayashi, Y., Nagaoka, K., Hosoi, A., Ikemura, S., Kitano, K., Kawada, I., Manabe, T., Takehara, T., Ebisudani, T., Nagayama, K., Nakamura, Y., Suzuki, R., Yasuda, H., Sato, M., Soejima, K. & Nakajima, J., 2020 Sep 18, In: Journal for ImmunoTherapy of Cancer. 8, 2, e001185.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zoledronic Acid
  • Adoptive Transfer
  • Non-Small Cell Lung Carcinoma
  • T-Lymphocytes
  • Cell- and Tissue-Based Therapy
  1 Citation (Scopus)

• Aggressive prostate cancer with somatic loss of the homologous recombination repair gene FANCA: A case report

  Hongo, H., Kosaka, T., Aimono, E., Nishihara, H. & Oya, M., 2020 Jan 13, In: Diagnostic Pathology. 15, 1, 5.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Recombinational DNA Repair
  • Prostatic Neoplasms
  • cabazitaxel
  • Castration
  • Genes
  1 Citation (Scopus)

• A Japanese patient with ductal carcinoma of the prostate carrying an adenomatosis polyposis coli gene mutation: a case report

  Umeda, K., Kosaka, T., Nakamura, K., Takeda, T., Mikami, S., Nishihara, H. & Oya, M., 2020 Aug 6, In: Diagnostic Pathology. 15, 1, 102.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Catenins
  • Adenomatous Polyposis Coli
  • Ductal Carcinoma
  • Prostate
  • Mutation

• A phase 2 basket trial of combination therapy with trastuzumab and pertuzumab in patients with solid cancers harboring human epidermal growth factor receptor 2 amplification (JUPITER trial)

  Takahashi, K., Ishibashi, E., Kubo, T., Harada, Y., Hayashi, H., Kano, M., Shimizu, Y., Shirota, H., Mori, Y., Muto, M., Ishioka, C., Dosaka-Akita, H., Matsubara, H., Nishihara, H., Sueoka-Aragane, N., Toyooka, S., Hirakawa, A., Tateishi, U., Miyake, S. & Ikeda, S., 2020 Aug 7, In: Medicine. 99, 32, p. e21457

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • pertuzumab
  • human ERBB2 protein
  • Trastuzumab
  • Neoplasms
  • Japan
  1 Citation (Scopus)

• Association of Epstein–Barr virus with regression after withdrawal of immunosuppressive drugs and subsequent progression of iatrogenic immunodeficiency-associated lymphoproliferative disorders in patients with autoimmune diseases

  Fujimoto, K., Hatanaka, K. C., Hatanaka, Y., Kasahara, I., Yamamoto, S., Tsuji, T., Nakata, M., Takakuwa, Y., Haseyama, Y., Oyamada, Y., Yonezumi, M., Suzuki, H., Sakai, H., Noguchi, H., Mori, A., Nishihara, H., Teshima, T. & Matsuno, Y., 2020 Dec, In: Hematological Oncology. 38, 5, p. 799-807 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Lymphoproliferative Disorders
  • Autoimmune Diseases
  • Immunosuppressive Agents
  • Viruses
  • Pharmaceutical Preparations

• Cancer gene profiling explores the possible precision medicine for diffuse-type gastric adenocarcinoma

  Ishikawa, M., Hayashi, H., Sakamoto, N., Tanaka, S. & Nishihara, H., 2020 Jan 1, In: Medical Oncology. 37, 1, 10.

  Research output: Contribution to journal › Article › peer-review

  • Precision Medicine
  • Neoplasm Genes
  • Stomach Neoplasms
  • Adenocarcinoma
  • Stomach

• CDK12 and HER2 coamplification in two urothelial carcinomas with rapid and aggressive clinical progression

  Yanai, Y., Kosaka, T., Nakamura, K., Aimono, E., Matsumoto, K., Morita, S., Mikami, S., Nishihara, H. & Oya, M., 2020 Dec, In: Cancer science. 111, 12, p. 4652-4655 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cyclin-Dependent Kinases
  • Carcinoma
  • TYK2 Kinase
  • ErbB-2 Receptor
  • Chromosomes, Human, Pair 17

• Clinical impact of a cancer genomic profiling test using an in-house comprehensive targeted sequencing system

  Hayashi, H., Tanishima, S., Fujii, K., Mori, R., Okada, C., Yanagita, E., Shibata, Y., Matsuoka, R., Amano, T., Yamada, T., Yabe, I., Kinoshita, I., Komatsu, Y., Dosaka-Akita, H. & Nishihara, H., 2020 Oct 1, In: Cancer science. 111, 10, p. 3926-3937 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Precision Medicine
  • Neoplasm Genes
  • Neoplasms
  • Exome
  • Feasibility Studies

• Detection of somatic TP53 mutation in surgically resected small-cell lung cancer by targeted exome sequencing: association with longer relapse-free survival

  Yokouchi, H., Nishihara, H., Harada, T., Yamazaki, S., Kikuchi, H., Oizumi, S., Uramoto, H., Tanaka, F., Harada, M., Akie, K., Sugaya, F., Fujita, Y., Takamura, K., Kojima, T., Higuchi, M., Honjo, O., Minami, Y., Watanabe, N., Nishimura, M., Suzuki, H. & 2 others, Dosaka-Akita, H. & Isobe, H., 2020 Jul, In: Heliyon. 6, 7, e04439.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Exome
  • Small Cell Lung Carcinoma
  • Recurrence
  • Mutation
  • Survival

• Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men

  Irie, J., Inagaki, E., Fujita, M., Nakaya, H., Mitsuishi, M., Yamaguchi, S., Yamashita, K., Shigaki, S., Ono, T., Yukioka, H., Okano, H., Nabeshima, Y. I., Imai, S. I., Yasui, M., Tsubota, K. & Itoh, H., 2020, In: Endocrine journal. 67, 2, p. 153-160 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nicotinamide Mononucleotide
  • Niacinamide
  • Oral Administration
  • NAD
  • N-methyl-2-pyridone-5-carboxamide
  17 Citations (Scopus)

• Establishment and characterization of a new malignant peritoneal mesothelioma cell line, KOG-1, from the ascitic fluid of a patient with pemetrexed chemotherapy resistance

  Akahane, T., Hirasawa, A., Imoto, I., Okubo, A., Itoh, M., Nanki, Y., Yoshihama, T., Tominaga, E. & Aoki, D., 2020 Jan 1, In: Human Cell. 33, 1, p. 272-282 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Pemetrexed
  • Malignant Mesothelioma
  • Ascitic Fluid
  • Cell Line
  • Drug Therapy

• Excessive EP4 Signaling in Smooth Muscle Cells Induces Abdominal Aortic Aneurysm by Amplifying Inflammation

  Hiromi, T., Yokoyama, U., Kurotaki, D., Mamun, A., Ishiwata, R., Ichikawa, Y., Nishihara, H., Umemura, M., Fujita, T., Yasuda, S., Minami, T., Goda, M., Uchida, K., Suzuki, S., Takeuchi, I., Masuda, M., Breyer, R. M., Tamura, T. & Ishikawa, Y., 2020, (Accepted/In press) In: Arteriosclerosis, Thrombosis, and Vascular Biology. p. 1559-1573 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Receptors, Prostaglandin E, EP4 Subtype
  • Abdominal Aortic Aneurysm
  • Smooth Muscle Myocytes
  • Inflammation
  • Vascular Smooth Muscle
  1 Citation (Scopus)

• Extramammary Paget’s disease patient-derived xenografts harboring ERBB2 S310F mutation show sensitivity to HER2-targeted therapies

  Maeda, T., Kitamura, S., Nishihara, H. & Yanagi, T., 2020 Sep 3, In: Oncogene. 39, 36, p. 5867-5875 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Extramammary Paget's Disease
  • Heterografts
  • Mutation
  • Inbred NOD Mouse
  • eribulin
  1 Citation (Scopus)

• Fatty Acid Synthesis Is Indispensable for Survival of Human Pluripotent Stem Cells

  Tanosaki, S., Tohyama, S., Fujita, J., Someya, S., Hishiki, T., Matsuura, T., Nakanishi, H., Ohto-Nakanishi, T., Akiyama, T., Morita, Y., Kishino, Y., Okada, M., Tani, H., Soma, Y., Nakajima, K., Kanazawa, H., Sugimoto, M., Ko, M. S. H., Suematsu, M. & Fukuda, K., 2020 Sep 25, In: iScience. 23, 9, 101535.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • metabolic flux analysis
  • metabolomics
  • cell biology
  • stem cells
  • proteomics
  2 Citations (Scopus)

• Gefitinib alone versus gefitinib plus chemotherapy for non–small-cell lung cancer with mutated epidermal growth factor receptor: NEJ009 study

  North-East Japan Study Group, 2020, In: Journal of Clinical Oncology. 38, 2, p. 115-123 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Gefitinib
  • ErbB Receptors
  • Non-Small Cell Lung Carcinoma
  • Drug Therapy
  • Progression-Free Survival
  60 Citations (Scopus)

• Genetic profiling of patients with adenoid cystic carcinoma of the Bartholin's glands reveals potential new routes for targeted therapies: A case report

  Nakamura, K., Aimono, E., Tanishima, S., Nomura, H., Imai, M., Hayashi, H. & Nishihara, H., 2020 May 28, In: Diagnostic Pathology. 15, 1, 64.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bartholin's Glands
  • Adenoid Cystic Carcinoma
  • Salivary Glands
  • Carcinogenesis
  • Mutation
  2 Citations (Scopus)

• Hypothesis generative head-to-head study comparing efficacy of afatinib and osimertinib based on immunological biomarkers in Japanese NSCLC patients with EGFR mutations (Heat on Beat study)

  Morikawa, K., Tanaka, H., Itani, H., Takata, S., Watanabe, S., Kishi, K., Soejima, K., Kaira, K., Kagamu, H., Yoshimura, K., Matsutani, N. & Seki, N., 2020, In: Therapeutic Advances in Medical Oncology. 12

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • osimertinib
  • Afatinib
  • Non-Small Cell Lung Carcinoma
  • Hot Temperature
  • Biomarkers

• Intracellular levels of reactive oxygen species correlate with ABT-263 sensitivity in non-small-cell lung cancer cells

  Ohgino, K., Terai, H., Yasuda, H., Nukaga, S., Hamamoto, J., Tani, T., Kuroda, A., Arai, D., Ishioka, K., Masuzawa, K., Ikemura, S., Kawada, I., Naoki, K., Fukunaga, K. & Soejima, K., 2020 Oct 1, In: Cancer science. 111, 10, p. 3793-3801 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • navitoclax
  • Non-Small Cell Lung Carcinoma
  • Reactive Oxygen Species
  • Myeloid Leukemia
  • Small Cell Lung Carcinoma
  1 Citation (Scopus)

• Intratumoral genomic heterogeneity may hinder precision medicine strategies in patients with serous ovarian carcinoma

  Nakamura, K., Aimono, E., Tanishima, S., Imai, M., Nagatsuma, A. K., Hayashi, H., Yoshimura, Y., Nakayama, K., Kyo, S. & Nishihara, H., 2020 Apr, In: Diagnostics. 10, 4, 200.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Precision Medicine
  • Medicine
  • Genes
  • Tumors
  • Amplification
  3 Citations (Scopus)

• Japan society of clinical oncology/Japanese society of medical oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors, cooperated by the Japanese society of pediatric hematology/oncology

  Naito, Y., Mishima, S., Akagi, K., Igarashi, A., Ikeda, M., Okano, S., Kato, S., Takano, T., Tsuchihara, K., Terashima, K., Nishihara, H., Nishiyama, H., Hiyama, E., Hirasawa, A., Hosoi, H., Maeda, O., Yatabe, Y., Okamoto, W., Ono, S., Kajiyama, H. & 6 others, Nagashima, F., Hatanaka, Y., Miyachi, M., Kodera, Y., Yoshino, T. & Taniguchi, H., 2020 Mar 1, In: International Journal of Clinical Oncology. 25, 3, p. 403-417 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • tropomyosin kinase
  • Medical Oncology
  • Hematology
  • Receptor Protein-Tyrosine Kinases
  • Japan
  4 Citations (Scopus)

• Japan Society of Clinical Oncology provisional clinical opinion for the diagnosis and use of immunotherapy in patients with deficient DNA mismatch repair tumors, cooperated by Japanese Society of Medical Oncology, First Edition

  Mishima, S., Taniguchi, H., Akagi, K., Baba, E., Fujiwara, Y., Hirasawa, A., Ikeda, M., Maeda, O., Muro, K., Nishihara, H., Nishiyama, H., Takano, T., Tsuchihara, K., Yatabe, Y., Kodera, Y. & Yoshino, T., 2020 Feb 1, In: International Journal of Clinical Oncology. 25, 2, p. 217-239 23 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Repair-Deficiency Disorders
  • DNA Mismatch Repair
  • Medical Oncology
  • Immunotherapy
  • Japan
  4 Citations (Scopus)

• Key prognostic factors for EGFR-mutated non-adenocarcinoma lung cancer patients in the Japanese Joint Committee of Lung Cancer Registry Database

  Kobayashi, K., Soejima, K., Fukunaga, K., Shintani, Y., Sekine, I., Shukuya, T., Takayama, K., Inoue, A., Okamoto, I., Kiura, K., Takahashi, K., Yamamoto, N., Takiguchi, Y., Miyaoka, E., Okumura, M. & Yoshino, I., 2020 Aug, In: Lung Cancer. 146, p. 236-243 8 p.

  Research output: Contribution to journal › Article › peer-review

  • ErbB Receptors
  • Registries
  • Lung Neoplasms
  • Databases
  • Protein-Tyrosine Kinases
  2 Citations (Scopus)

• Kimura Disease Presenting with Buccal Mass: A Case Report and Literature Review

  Sato, R., Bandoh, N., Goto, T., Ichikawa, H., Uemura, A., Suzuki, S., Yamaguchi, T., Aimono, E., Nishihara, H., Katada, A. & Harabuchi, Y., 2020, (Accepted/In press) In: Head and Neck Pathology.

  Research output: Contribution to journal › Article › peer-review

  • Angiolymphoid Hyperplasia with Eosinophilia
  • Cheek
  • Germinal Center
  • Immunoglobulin E
  • Eosinophils

• Multiple squamous cell carcinomas arising on an epidermal nevus harboring HRAS p.G13R mutation

  Narahira, A., Kitamura, S., Maeda, T., Nishihara, H. & Yanagi, T., 2020, (Accepted/In press) In: Journal of Dermatology.

  Research output: Contribution to journal › Letter › peer-review

• Next-generation sequencing in residual liquid-based cytology specimens for cancer genome analysis

  Yamaguchi, T., Akahane, T., Harada, O., Kato, Y., Aimono, E., Takei, H., Tasaki, T., Noguchi, H., Nishihara, H., Kamata, H. & Tanimoto, A., 2020 Nov 1, In: Diagnostic Cytopathology. 48, 11, p. 965-971 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell Biology
  • Genome
  • Gene Frequency
  • Neoplasms
  • DNA
  1 Citation (Scopus)

• O-glycan-altered extracellular vesicles: A specific serum marker elevated in pancreatic cancer

  Yokose, T., Kabe, Y., Matsuda, A., Kitago, M., Matsuda, S., Hirai, M., Nakagawa, T., Masugi, Y., Hishiki, T., Nakamura, Y., Shinoda, M., Yagi, H., Abe, Y., Oshima, G., Hori, S., Nakano, Y., Honda, K., Kashiro, A., Morizane, C., Nara, S. & 12 others, Kikuchi, S., Shibahara, T., Itonaga, M., Ono, M., Minegishi, N., Koshiba, S., Yamamoto, M., Kuno, A., Handa, H., Sakamoto, M., Suematsu, M. & Kitagawa, Y., 2020 Sep, In: Cancers. 12, 9, p. 1-17 17 p., 2469.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Extracellular Vesicles
  • Pancreatic Neoplasms
  • Polysaccharides
  • Biomarkers
  • Lectins
  2 Citations (Scopus)

• Osimertinib Overcomes Alectinib Resistance Caused by Amphiregulin in a Leptomeningeal Carcinomatosis Model of ALK-Rearranged Lung Cancer

  Arai, S., Takeuchi, S., Fukuda, K., Taniguchi, H., Nishiyama, A., Tanimoto, A., Satouchi, M., Yamashita, K., Ohtsubo, K., Nanjo, S., Kumagai, T., Katayama, R., Nishio, M., Zheng, M. M., Wu, Y. L., Nishihara, H., Yamamoto, T., Nakada, M. & Yano, S., 2020 May, In: Journal of Thoracic Oncology. 15, 5, p. 752-765 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • CH5424802
  • osimertinib
  • Meningeal Carcinomatosis
  • Amphiregulin
  • Anaplastic Lymphoma Kinase
  8 Citations (Scopus)

• Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing

  Nanki, Y., Chiyoda, T., Hirasawa, A., Ookubo, A., Itoh, M., Ueno, M., Akahane, T., Kameyama, K., Yamagami, W., Kataoka, F. & Aoki, D., 2020 Dec 1, In: Scientific reports. 10, 1, 12581.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Organoids
  • Drug Resistance
  • Ovarian Neoplasms
  • Neoplasms
  • olaparib
  4 Citations (Scopus)

• Reduced fatty acid uptake aggravates cardiac contractile dysfunction in streptozotocin-induced diabetic cardiomyopathy

  Umbarawan, Y., Kawakami, R., Syamsunarno, M. R. A. A., Koitabashi, N., Obinata, H., Yamaguchi, A., Hanaoka, H., Hishiki, T., Hayakawa, N., Sunaga, H., Matsui, H., Kurabayashi, M. & Iso, T., 2020 Dec, In: Scientific reports. 10, 1, 20809.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Diabetic Cardiomyopathies
  • Streptozocin
  • Fatty Acids
  • Heart
  • Glycolysis

• Resection of a desmoid-type fibromatosis with a CTNNB1 p.S45P mutation using a cervico-thoracic approach: A case report and literature review

  Sato, R., Bandoh, N., Goto, T., Uemura, A., Inoue, N., Otomo, Y., Nakano, H., Yamaguchi, T., Kato, Y., Nishihara, H., Takei, H. & Harabuchi, Y., 2020, (Accepted/In press) In: Auris Nasus Larynx.

  Research output: Contribution to journal › Article › peer-review

  • Aggressive Fibromatosis
  • Fibroma
  • Thorax
  • Mutation
  • Clavicle

• Successful Retreatment Using Pembrolizumab for Non–small-cell Lung Cancer After Severe Immune-related Hepatitis: A Case Report

  Kobayashi, K., Nakachi, I., Mitsuishi, A., Arai, D., Sakurai, K., Masaki, K., Chiyotani, A., Takahashi, H., Tahara, T. & Soejima, K., 2020 Jan, In: Clinical Lung Cancer. 21, 1, p. e30-e32

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• The NOTCH–FOXM1 axis plays a key role in mitochondrial biogenesis in the induction of human stem cell memory–like CAR-T cells

  Kondo, T., Ando, M., Nagai, N., Tomisato, W., Srirat, T., Liu, B., Mise-Omata, S., Ikeda, M., Chikuma, S., Nishimasu, H., Nureki, O., Ohmura, M., Hayakawa, N., Hishiki, T., Uchibori, R., Ozawa, K. & Yoshimura, A., 2020 Feb 1, In: Cancer Research. 80, 3, p. 471-483 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Organelle Biogenesis
  • Stem Cells
  • T-Lymphocytes
  • Adoptive Immunotherapy
  • Stromal Cells
  7 Citations (Scopus)

• がんゲノム医療における患者対応の経験から

  Aimono, E., Iguchi, A., Mochida, K., Imai, M., Hayashi, H. & Nishihara, H., 2020 May 1, In: Yakugaku Zasshi. 140, 5, p. 667-668 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ambulatory Care
  • Learning
  • Medicine
  • Neoplasms
  • Counselors

• ゲノム医療に求められるシステム構築と人材について

  Aimono, E. & Nishihara, H., 2020 May 1, In: Yakugaku Zasshi. 140, 5, p. 651-655 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Workforce
  • Precision Medicine
  • Hereditary Neoplastic Syndromes
  • Pharmacists
  • Medicine
• 2019

  Acute Interstitial Nephritis With Karyomegalic Epithelial Cells After Nivolumab Treatment—Two Case Reports

  Ryuzaki, M., Tokuyama, H., Uchiyama, K., Nakaya, H., Hasegawa, K., Miyashita, K., Konishi, K., Hashiguchi, A., Wakino, S. & Itoh, H., 2019 Jun 1, In: Clinical Medicine Insights: Case Reports. 12

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nivolumab
  • Interstitial Nephritis
  • Epithelial Cells
  • Kidney
  • Renal Cell Carcinoma
  3 Citations (Scopus)

• A first Japanese case of neuroendocrine prostate cancer accompanied by lung and brain metastasis with somatic and germline BRCA2 mutation

  Kosaka, T., Hongo, H., Aimono, E., Matsumoto, K., Hayashida, T., Mikami, S., Nishihara, H. & Oya, M., 2019 Dec 1, In: Pathology international. 69, 12, p. 715-720 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Germ-Line Mutation
  • Brain Neoplasms
  • Lung Neoplasms
  • Prostatic Neoplasms
  • Platinum
  2 Citations (Scopus)

• Analysis of DLL3 and ASCL1 in Surgically Resected Small Cell Lung Cancer (HOT1702)

  on behalf of Hokkaido Lung Cancer Clinical Study Group, 2019 Nov 1, In: Oncologist. 24, 11, p. e1172-e1179

  Research output: Contribution to journal › Article › peer-review

  • delta protein
  • Small Cell Lung Carcinoma
  • rovalpituzumab tesirine
  • Immunoconjugates
  9 Citations (Scopus)

• A phase II trial of induction of erlotinib followed by cytotoxic chemotherapy for EGFR mutation-positive non-squamous non-small cell lung cancer patients

  Tani, T., Naoki, K., Yasuda, H., Arai, D., Ishioka, K., Ohgino, K., Yoda, S., Nakayama, S., Satomi, R., Terai, H., Ikemura, S., Sato, T. & Soejima, K., 2019 Nov 1, In: Cancer Chemotherapy and Pharmacology. 84, 5, p. 1065-1071 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemotherapy
  • Erlotinib Hydrochloride
  • Cells
  • Non-Small Cell Lung Carcinoma
  • Drug Therapy
  2 Citations (Scopus)

• Brain metastases in oncogene-driven non-small cell lung cancer

  Nishino, M., Soejima, K. & Mitsudomi, T., 2019, In: Translational Lung Cancer Research. 8, p. S298-S307

  Research output: Contribution to journal › Review article › peer-review

  • Oncogenes
  • Non-Small Cell Lung Carcinoma
  • Anaplastic Lymphoma Kinase
  • Neoplasm Metastasis
  • Brain
  6 Citations (Scopus)

• Comprehensive validation of liquid-based cytology specimens for next-generation sequencing in cancer genome analysis

  Akahane, T., Yamaguchi, T., Kato, Y., Yokoyama, S., Hamada, T., Nishida, Y., Higashi, M., Nishihara, H., Suzuki, S., Ueno, S. & Tanimoto, A., 2019 Jun, In: PloS one. 14, 6, e0217724.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cytology
  • cell biology
  • Genes
  • Cell Biology
  • neoplasms
  6 Citations (Scopus)

• Effectiveness of a genetic test panel designed for gynecological cancer: an exploratory study

  Ida, K., Miyamoto, T., Higuchi, S., Takeuchi, H., Yamada, S., Ono, M., Nishihara, H. & Shiozawa, T., 2019 Jul 1, In: Medical Oncology. 36, 7, 62.

  Research output: Contribution to journal › Article › peer-review

  • Neoplasms
  • Formaldehyde
  • Paraffin
  • Cost-Benefit Analysis
  • Ions
  1 Citation (Scopus)

• Efficacy of afatinib or osimertinib plus cetuximab combination therapy for non-small-cell lung cancer with EGFR exon 20 insertion mutations

  Hasegawa, H., Yasuda, H., Hamamoto, J., Masuzawa, K., Tani, T., Nukaga, S., Hirano, T., Kobayashi, K., Manabe, T., Terai, H., Ikemura, S., Kawada, I., Naoki, K. & Soejima, K., 2019 Jan, In: Lung Cancer. 127, p. 146-152 7 p.

  Research output: Contribution to journal › Article › peer-review

  • osimertinib
  • Afatinib
  • Cetuximab
  • Insertional Mutagenesis
  • ErbB Receptors
  17 Citations (Scopus)

• Epithelial-to-mesenchymal transition is a mechanism of ALK inhibitor resistance in lung cancer independent of ALK mutation status

  Fukuda, K., Takeuchi, S., Arai, S., Katayama, R., Nanjo, S., Tanimoto, A., Nishiyama, A., Nakagawa, T., Taniguchi, H., Suzuki, T., Yamada, T., Nishihara, H., Ninomiya, H., Ishikawa, Y., Baba, S., Takeuchi, K., Horiike, A., Yanagitani, N., Nishio, M. & Yano, S., 2019 Apr 1, In: Cancer Research. 79, 7, p. 1658-1670 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Epithelial-Mesenchymal Transition
  • Lung Neoplasms
  • Crizotinib
  • Mutation
  • Histone Deacetylase Inhibitors
  26 Citations (Scopus)

• Establishment of permutation for cancer risk estimation in the urothelium based on genome-wide DNA methylation analysis

  Tsumura, K., Arai, E., Tian, Y., Shibuya, A., Nishihara, H., Yotani, T., Yamada, Y., Takahashi, Y., Maeshima, A. M., Fujimoto, H., Nakagawa, T., Kume, H., Homma, Y., Yoshida, T. & Kanai, Y., 2019 Nov 25, In: Carcinogenesis. 40, 11, p. 1308-1319 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Urothelium
  • DNA Methylation
  • Genome
  • Neoplasms
  • Sensitivity and Specificity
  6 Citations (Scopus)