Clinical Research Aministration Center

Research output

Research output per year 2001 2001 2003 2004 2011 2013 2014 2015 2019

• 26 Article

Research output per year

Research output per year

Search results

• 2019

  Rituximab therapy for refractory autoimmune bullous diseases: A multicenter, open-label, single-arm, phase 1/2 study on 10 Japanese patients

  Kurihara, Y., Yamagami, J., Funakoshi, T., Ishii, M., Miyamoto, J., Fujio, Y., Kakuta, R., Tanikawa, A., Aoyama, Y., Iwatsuki, K., Ishii, N., Hashimoto, T., Nishie, W., Shimizu, H., Kouyama, K. & Amagai, M., 2019 Feb, In: Journal of Dermatology. 46, 2, p. 124-130 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Pemphigus 100%
  • Rituximab 86%
  • Autoimmune Diseases 68%
  • Bullous Pemphigoid 41%
  • Infectious Arthritis 19%
  14 Citations (Scopus)
• 2018

  Characterization of centriole duplication in human epidermis, Bowen's disease, and squamous cell carcinoma

  Watanuki, S., Fujita, H., Kouyama, K., Amagai, M. & Kubo, A., 2018 Jul, In: Journal of Dermatological Science. 91, 1, p. 9-18 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Bowen's Disease 100%
  • Centrioles 99%
  • Epidermis 69%
  • Squamous Cell Carcinoma 58%
  • Fiber 44%
  1 Citation (Scopus)
• 2016

  Effects of laser in situ keratomileusis on mental health-related quality of life

  Tounaka-Fujii, K., Yuki, K., Negishi, K., Toda, I., Abe, T., Kouyama, K. & Tsubota, K., 2016 Sept 26, In: Clinical Ophthalmology. 10, p. 1859-1864 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Laser In Situ Keratomileusis 100%
  • Mental Health 61%
  • Quality of Life 50%
  • Health Surveys 15%
  • Ocular Vision 13%
  2 Citations (Scopus)
• 2015

  Glaucomatous visual field defect severity and the prevalence of motor vehicle collisions in Japanese: A hospital/clinic-based cross-sectional study

  Ono, T., Yuki, K., Asaoka, R., Kouyama, K., Abe, T., Tanabe, S., Fukagawa, K., Uchino, M., Shimoyama, M., Ozawa, Y., Ozeki, N., Shiba, D. & Tsubota, K., 2015, In: Journal of Ophthalmology. 2015, 497067.

  Research output: Contribution to journal › Article › peer-review

  • Open Angle Glaucoma 100%
  • Motor Vehicles 96%
  • Visual Fields 88%
  • Cross-Sectional Studies 57%
  • Eye 20%
  14 Citations (Scopus)

• Risk factors for decreased bone mineral density in inflammatory bowel disease: A cross-sectional study

  Wada, Y., Hisamatsu, T., Naganuma, M., Matsuoka, K., Okamoto, S., Inoue, N., Yajima, T., Kouyama, K., Iwao, Y., Ogata, H., Hibi, T., Abe, T. & Kanai, T., 2015 Dec 1, In: Clinical Nutrition. 34, 6, p. 1202-1209 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Inflammatory Bowel Diseases 100%
  • Bone Density 95%
  • Cross-Sectional Studies 69%
  • Metabolic Bone Diseases 57%
  • Ulcerative Colitis 52%
  26 Citations (Scopus)
• 2014

  Distinct behavior of human Langerhans cells and inflammatory dendritic epidermal cells at tight junctions in patients with atopic dermatitis

  Yoshida, K., Kubo, A., Fujita, H., Yokouchi, M., Ishii, K., Kawasaki, H., Nomura, T., Shimizu, H., Kouyama, K., Ebihara, T., Nagao, K. & Amagai, M., 2014 Oct 1, In: Journal of Allergy and Clinical Immunology. 134, 4, p. 856-864 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Langerhans Cells 100%
  • Tight Junctions 94%
  • Atopic Dermatitis 87%
  • Dendrites 19%
  • Skin 17%
  88 Citations (Scopus)

• Dry eye disease is associated with deterioration of mental health in male Japanese university staff

  Tounaka, K., Yuki, K., Kouyama, K., Abe, T., Tsubota, K., Kawabe, H. & Yokoyama, K., 2014, In: The Tohoku journal of experimental medicine. 233, 3, p. 215-220 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ocular 100%
  • Dry Eye Syndromes 93%
  • Mental Health 61%
  • Surface 24%
  • Quality of Life 22%
  8 Citations (Scopus)
• 2013

  Postoperative flat anterior chamber: Incidence, risk factors, and effect on the long-term success of trabeculectomy

  Ono, T., Yuki, K., Shiba, D., Abe, T., Kouyama, K. & Tsubota, K., 2013 Nov 1, In: Japanese Journal of Ophthalmology. 57, 6, p. 520-528 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Trabeculectomy 100%
  • Anterior Chamber 87%
  • Intraocular Pressure 61%
  • Incidence 39%
  • Eye 11%
  3 Citations (Scopus)

• Preoperative and intraoperative assessment of myometrial invasion in endometrial cancer: Comparison of magnetic resonance imaging and frozen sections

  Kisu, I., Banno, K., Lin, L. Y., Ueno, A., Abe, T., Kouyama, K., Okuda, S., Masugi, Y., Umene, K., Nogami, Y., Tsuji, K., Masuda, K., Ueki, A., Kobayashi, Y., Yamagami, W., Susumu, N. & Aoki, D., 2013 May, In: Acta Obstetricia et Gynecologica Scandinavica. 92, 5, p. 525-535 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Frozen Sections 100%
  • Endometrial Neoplasms 93%
  • Magnetic Resonance Imaging 60%
  • Sensitivity and Specificity 15%
  • University Hospitals 7%
  22 Citations (Scopus)

• The association between visual field defect severity and fear of falling in primary open-angle glaucoma

  Yuki, K., Tanabe, S., Kouyama, K., Fukagawa, K., Uchino, M., Shimoyama, M., Ozeki, N., Shiba, D., Ozawa, Y., Abe, T. & Tsubota, K., 2013 Nov 21, In: Investigative Ophthalmology and Visual Science. 54, 12, p. 7739-7745 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Open Angle Glaucoma 100%
  • Visual Fields 88%
  • Fear 76%
  • Accidental Falls 69%
  • Confidence Intervals 34%
  23 Citations (Scopus)
• 2012

  Indocyanine green fluorescence imaging for evaluation of uterine blood flow in cynomolgus macaque

  Kisu, I., Banno, K., Mihara, M., Lin, L. Y., Tsuji, K., Yanokura, M., Hara, H., Araki, J., Iida, T., Abe, T., Kouyama, K., Suganuma, N. & Aoki, D., 2012 Apr 20, In: PloS one. 7, 4, e35124.

  Research output: Contribution to journal › Article › peer-review

  • Hemodynamic 100%
  • Indocyanine Green 97%
  • Macaca fascicularis 80%
  • Macaca 76%
  • Optical Imaging 74%
  35 Citations (Scopus)
• 2011

  Flexible hysteroscopy with narrow band imaging (NBI) for endoscopic diagnosis of malignant endometrial lesions

  Kisu, I., Banno, K., Kobayashi, Y., Ono, A., Masuda, K., Ueki, A., Nomura, H., Hirasawa, A., Abe, T., Kouyama, K., Susumu, N. & Aoki, D., 2011 Mar, In: International journal of oncology. 38, 3, p. 613-618 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Narrow Band Imaging 100%
  • Hysteroscopy 88%
  • Endometrial Hyperplasia 18%
  • Confidence Intervals 16%
  • Endometrial Neoplasms 14%
  11 Citations (Scopus)

• Narrow band imaging hysteroscopy: A comparative study using randomized video images

  Kisu, I., Banno, K., Kobayashi, Y., Ono, A., Masuda, K., Ueki, A., Nomura, H., Hirasawa, A., Abe, T., Kouyama, K., Susumu, N. & Aoki, D., 2011 Nov, In: International journal of oncology. 39, 5, p. 1057-1062 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Narrow Band Imaging 100%
  • Hysteroscopy 88%
  • Light 26%
  • Endometrial Hyperplasia 21%
  • Endometrial Neoplasms 16%
  7 Citations (Scopus)

• The association between primary open-angle glaucoma and motor vehicle collisions

  Tanabe, S., Yuki, K., Ozeki, N., Shiba, D., Abe, T., Kouyama, K. & Tsubota, K., 2011 Jun, In: Investigative Ophthalmology and Visual Science. 52, 7, p. 4177-4181 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Open Angle Glaucoma 100%
  • Motor Vehicles 96%
  • Age Factors 9%
  • Eye Diseases 9%
  • Visual Fields 8%
  51 Citations (Scopus)
• 2010

  Clinical research in Japan: Past, present and future

  Sato, Y. & Koyama, K., 2010 Sept, In: Keio Journal of Medicine. 59, 3, p. 104-109 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Japan 100%
  • Drug Approval 31%
  • Clinical Trials 15%
  • Equipment and Supplies 14%
  • Therapeutics 3%
  6 Citations (Scopus)
• 2008

  A Real-Time Three-Dimensional Echocardiographic Quantitative Analysis of Left Atrial Function in Left Ventricular Diastolic Dysfunction

  Murata, M., Iwanaga, S., Tamura, Y., Kondo, M., Kouyama, K., Murata, M. & Ogawa, S., 2008 Oct 15, In: American Journal of Cardiology. 102, 8, p. 1097-1102 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Left Atrial Function 100%
  • Left Ventricular Dysfunction 72%
  • Left Ventricular Function 66%
  • Echocardiography 42%
  • Stroke Volume 30%
  70 Citations (Scopus)
• 2005

  A humanin derivative, S14G-HN, prevents amyloid-β-induced memory impairment in mice

  Tajima, H., Kawasumi, M., Chiba, T., Yamada, M., Yamashita, K., Nawa, M., Kita, Y., Kouyama, K., Aiso, S., Matsuoka, M., Niikura, T. & Nishimoto, I., 2005 Mar 1, In: Journal of neuroscience research. 79, 5, p. 714-723 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Gly(14)-Humanin 100%
  • humanin 82%
  • Amyloid 44%
  • Memory 34%
  • Amnesia 21%
  92 Citations (Scopus)
• 2004

  Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid-β peptides via p75NTR/PLAIDD

  Hashimoto, Y., Kaneko, Y., Tsukamoto, E., Frankowski, H., Kouyama, K., Kita, Y., Niikura, T., Aiso, S., Bredesen, D. E., Matsuoka, M. & Nishimoto, I., 2004 Aug 1, In: Journal of Neurochemistry. 90, 3, p. 549-558 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Death Domain 100%
  • Nerve Growth Factor Receptor 92%
  • Cell Death 75%
  • Amyloid 66%
  • Peptides 44%
  55 Citations (Scopus)

• Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice

  Kawasumi, M., Chiba, T., Yamada, M., Miyamae-Kaneko, M., Matsuoka, M., Nakahara, J., Tomita, T., Iwatsubo, T., Kato, S., Aiso, S., Nishimoto, I. & Kouyama, K., 2004 May 1, In: European Journal of Neuroscience. 19, 10, p. 2826-2838 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Amyloid beta-Protein Precursor 100%
  • Alzheimer Disease 66%
  • Mutation 48%
  • Genes 34%
  • Short-Term Memory 27%
  47 Citations (Scopus)
• 2003

  Analysis of neurons created from wild-type and Alzheimer's mutation knock-in embryonic stem cells by a highly efficient differentiation protocol

  Abe, Y., Kouyama, K., Tomita, T., Tomita, Y., Ban, N., Nawa, M., Matsuoka, M., Niikura, T., Aiso, S., Kita, Y., Iwatsubo, T. & Nishimoto, I., 2003 Sept 17, In: Journal of Neuroscience. 23, 24, p. 8513-8525 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Embryonic Stem Cells 100%
  • Neurons 57%
  • Mutation 52%
  • Alzheimer Disease 51%
  • Amyloid beta-Protein Precursor 32%
  25 Citations (Scopus)

• Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death

  Hashimoto, Y., Tsuji, O., Niikura, T., Yamagishi, Y., Ishizaka, M., Kawasumi, M., Chiba, T., Kanekura, K., Yamada, M., Tsukamoto, E., Kouyama, K., Terashita, K., Aiso, S., Lint, A. & Nishimoto, I., 2003 Feb 1, In: Journal of Neurochemistry. 84, 4, p. 864-877 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Amyloid beta-Protein Precursor 100%
  • JNK Mitogen-Activated Protein Kinases 97%
  • Cell Death 92%
  • Pertussis Toxin 29%
  • Neurotoxicity 24%
  91 Citations (Scopus)
• 2002

  p53-independent apoptosis is induced by the p19^ARF tumor suppressor

  Tsuji, K., Mizumoto, K., Sudo, H., Kouyama, K., Ogata, E. & Matsuoka, M., 2002, In: Biochemical and Biophysical Research Communications. 295, 3, p. 621-629 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Apoptosis 100%
  • Cell Cycle Checkpoints 53%
  • Neoplasms 52%
  • Fibroblasts 40%
  • Cell Line 32%
  33 Citations (Scopus)
• 2001

  A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ

  Hashimoto, Y., Niikura, T., Tajima, H., Yasukawa, T., Sudo, H., Ito, Y., Kita, Y., Kawasumi, M., Kouyama, K., Doyu, M., Sobue, G., Koide, T., Tsuji, S., Lang, J., Kurokawa, K. & Nishimoto, I., 2001 May 22, In: Proceedings of the National Academy of Sciences of the United States of America. 98, 11, p. 6336-6341 6 p.

  Research output: Contribution to journal › Article › peer-review

  • humanin 100%
  • Alzheimer Disease 44%
  • Cell Death 43%
  • Peptides 36%
  • Complementary DNA 30%
  472 Citations (Scopus)

• c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK

  Matsuda, S., Yasukawa, T., Homma, Y., Ito, Y., Niikura, T., Hiraki, T., Hirai, S., Ohno, S., Kita, Y., Kawasumi, M., Kouyama, K., Yamamoto, T., Kyriakis, J. M. & Nishimoto, I., 2001 Sept 1, In: Journal of Neuroscience. 21, 17, p. 6597-6607 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Amyloid beta-Protein Precursor 100%
  • JNK Mitogen-Activated Protein Kinases 97%
  • Phosphotyrosine 43%
  • Brain 42%
  • Proteins 31%
  164 Citations (Scopus)

• Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner

  Niikura, T., Hashimoto, Y., Okamoto, T., Abe, Y., Yasukawa, T., Kawasumi, M., Hiraki, T., Kita, Y., Terashita, K., Kouyama, K. & Nishimoto, I., 2001 Mar 15, In: Journal of Neuroscience. 21, 6, p. 1902-1910 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Insulin-Like Growth Factor Binding Proteins 100%
  • IGF Type 1 Receptor 96%
  • Mutant Proteins 81%
  • Insulin-Like Growth Factor I 76%
  • Amyloid 72%
  66 Citations (Scopus)

• Secreted Aβ does not mediate neurotoxicity by antibody-stimulated amyloid precursor protein

  Sudo, H., Hashimoto, Y., Niikura, T., Shao, Z., Yasukawa, T., Ito, Y., Yamada, M., Hata, M., Hiraki, T., Kawasumi, M., Kouyama, K. & Nishimoto, I., 2001, In: Biochemical and Biophysical Research Communications. 282, 2, p. 548-556 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Neurotoxicity 100%
  • Amyloid beta-Protein Precursor 92%
  • Anti-Idiotypic Antibodies 67%
  • Neurotoxic 50%
  • Antibodies 44%
  31 Citations (Scopus)