Department of Internal Medicine (Nephrology, Endocrinology and Metabolism)

2023

Canagliflozin protects the cardiovascular system through effects on the gut environment in non-diabetic nephrectomized rats

Matsui, A., Yoshifuji, A., Irie, J., Tajima, T., Uchiyama, K., Itoh, T., Wakino, S. & Itoh, H., 2023 Apr, In: Clinical and experimental nephrology. 27, 4, p. 295-308 14 p.

Research output: Contribution to journal › Article › peer-review

Case report: Importance of early and continuous tocilizumab therapy in nephrotic syndrome associated with idiopathic multicentric Castleman disease: A case series

Kojima, D., Yamaguchi, S., Hashiguchi, A., Hayashi, K., Uchiyama, K., Yoshimoto, N., Adachi, K., Nakayama, T., Nishioka, K., Tajima, T., Morimoto, K., Yoshino, J., Yoshida, T., Monkawa, T., Kanda, T. & Itoh, H., 2023 Jan 9, In: Frontiers in Medicine. 9, 1037032.

Research output: Contribution to journal › Article › peer-review

Open Access

Mechanisms of mineralocorticoid receptor-associated hypertension in diabetes mellitus: the role of O-GlcNAc modification

Jo, R., Shibata, H., Kurihara, I., Yokota, K., Kobayashi, S., Murai-Takeda, A., Mitsuishi, Y., Hayashi, T., Nakamura, T. & Itoh, H., 2023 Jan, In: Hypertension Research. 46, 1, p. 19-31 13 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Significance of podocyte DNA damage and glomerular DNA methylation in CKD patients with proteinuria

Yoshimoto, N., Hayashi, K., Hishikawa, A., Hashiguchi, A., Nakamichi, R., Sugita-Nishimura, E., Yoshida-Hama, E., Azegami, T., Nakayama, T. & Itoh, H., 2023, (Accepted/In press) In: Hypertension Research.

Research output: Contribution to journal › Article › peer-review

2022

Amiodarone-induced multiple organ damage in an Alström syndrome patient with end-stage renal disease and hepatic cirrhosis

Torimitsu, T., Yoshida, T., Makiuchi, S., Itoh, H. & Oya, M., 2022 Feb 1, In: CEN case reports. 11, 1, p. 11-16 6 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Antibiotic-induced microbiome depletion remodels daily metabolic cycles in the brain

Smith, J. G., Sato, T., Shimaji, K., Koronowski, K. B., Petrus, P., Cervantes, M., Kinouchi, K., Lutter, D., Dyar, K. A. & Sassone-Corsi, P., 2022 Aug 15, In: Life Sciences. 303, 120601.

Research output: Contribution to journal › Article › peer-review

Open Access

Associated factors and effects of comorbid atrial fibrillation in hypertensive patients due to primary aldosteronism

JRAS investigators, 2022, (Accepted/In press) In: Journal of Human Hypertension.

Research output: Contribution to journal › Article › peer-review

Changes in glycemic variability, gastric emptying and vascular endothelial function after switching from twice-daily to once-weekly exenatide in patients with type 2 diabetes: a subpopulation analysis of the twin-exenatide study

Inaishi, J., Saisho, Y., Watanabe, Y., Tsuchiya, T., Sasaki, H., Masaoka, T. & Itoh, H., 2022 Dec, In: BMC Endocrine Disorders. 22, 1, 20.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Comparison and commutability study between standardized liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) and chemiluminescent enzyme immunoassay for aldosterone measurement in blood

Nishikawa, T., Satoh, F., Takashi, Y., Yanase, T., Itoh, H., Kurihara, I., Shibata, H., Oki, Y., Naruse, M., Sasamoto, H. & Kuwa, K., 2022, In: Endocrine journal. 69, 1, p. 45-54 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

Development of Alveolar Hemorrhage After Pfizer-BioNTech COVID-19 mRNA Vaccination in a Patient With Renal-Limited Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Case Report

Nishioka, K., Yamaguchi, S., Yasuda, I., Yoshimoto, N., Kojima, D., Kaneko, K., Aso, M., Nagasaka, T., Yoshida, E., Uchiyama, K., Tajima, T., Yoshino, J., Yoshida, T., Kanda, T. & Itoh, H., 2022 Apr 8, In: Frontiers in Medicine. 9, 874831.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

DNA methylation analysis of cord blood samples in neonates born to gestational diabetes mothers diagnosed before 24 gestational weeks

Kasuga, Y., Kawai, T., Miyakoshi, K., Hori, A., Tamagawa, M., Hasegawa, K., Ikenoue, S., Ochiai, D., Saisho, Y., Hida, M., Tanaka, M. & Hata, K., 2022 Jan 19, In: BMJ Open Diabetes Research and Care. 10, 1, e002539.

Research output: Contribution to journal › Article › peer-review

Open Access

Effect of esaxerenone on nocturnal blood pressure and natriuretic peptide in different dipping phenotypes

Kario, K., Ito, S., Itoh, H., Rakugi, H., Okuda, Y. & Yamakawa, S., 2022 Jan, In: Hypertension Research. 45, 1, p. 97-105 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Citations (Scopus)

Effect of Tolvaptan in Patients with Chronic Kidney Disease Stage G5, and Impact of Concomitant Use of Thiazide Diuretics: A Retrospective Cohort Study

Uchiyama, K., Kojima, D., Hama, E. Y., Nagasaka, T., Nakayama, T., Takahashi, R., Tajima, T., Morimoto, K., Washida, N. & Itoh, H., 2022 Dec, In: Drugs - Real World Outcomes. 9, 4, p. 649-657 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Effects of a remote patient monitoring system for patients on automated peritoneal dialysis: a randomized crossover controlled trial

Uchiyama, K., Morimoto, K., Washida, N., Kusahana, E., Nakayama, T., Itoh, T., Kasai, T., Wakino, S. & Itoh, H., 2022 Oct, In: International Urology and Nephrology. 54, 10, p. 2673-2681 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Effects of renin-angiotensin system inhibitors on the incidence of unplanned dialysis

Nakayama, T., Morimoto, K., Uchiyama, K., Kusahana, E., Washida, N., Azegami, T., Kanda, T., Yoshida, T. & Itoh, H., 2022 Jun, In: Hypertension Research. 45, 6, p. 1018-1027 10 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Efficacy of dexmedetomidine on peritoneal dialysis catheter insertion

Nakayama, T., Uchiyama, K., Morimoto, K., Washida, N., Kasai, T., Nakamichi, R., Kusahana, E., Wakino, S. & Itoh, H., 2022 Jan, In: International Urology and Nephrology. 54, 1, p. 209-215 7 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Eosinophilic Reaction at the Time of Catheter Insertion Predicts Survival in Patients Initiating Peritoneal Dialysis

Uchiyama, K., Washida, N., Kusahana, E., Nakayama, T., Morimoto, K. & Itoh, H., 2022 Apr 1, In: Blood Purification. 51, 4, p. 355-364 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Fibronectin Glomerulopathy Confused with Glomerular Endothelial Injury in a Patient with Takotsubo Cardiomyopathy

Azegami, T., Hashiguchi, A., Nakayama, T., Hayashi, K., Kanda, T. & Itoh, H., 2022, In: Internal Medicine. 61, 13, p. 2027-2032 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Health-Related Quality of Life Sleep Score Predicts Transfer to Hemodialysis among Patients on Peritoneal Dialysis

Nagasaka, T., Washida, N., Uchiyama, K., Hama, E. Y., Kusahana, E., Nakayama, T., Yasuda, I., Morimoto, K. & Itoh, H., 2022 Jun, In: Healthcare (Switzerland). 10, 6, 1030.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

High body mass index is a risk factor for transition to hemodialysis or hybrid therapy and peritoneal dialysis-related infection in Japanese patients undergoing peritoneal dialysis

Hama, E. Y., Uchiyama, K., Nagasaka, T., Kusahana, E., Nakayama, T., Yasuda, I., Morimoto, K., Washida, N. & Itoh, H., 2022 Dec, In: International Urology and Nephrology. 54, 12, p. 3193-3202 10 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Iliopsoas abscess in patients receiving hemodialysis: a case series and a literature survey

Oshida, T., Yoshida, T., Itoh, H. & Oya, M., 2022 Dec, In: Renal Replacement Therapy. 8, 1, 33.

Research output: Contribution to journal › Article › peer-review

Open Access

Impaired early phase insulin secretion associated with gestational diabetes mellitus in underweight women

Kasuga, Y., Miyakoshi, K., Saisho, Y., Ikenoue, S., Ochiai, D. & Tanaka, M., 2022, In: Journal of Maternal-Fetal and Neonatal Medicine. 35, 12, p. 2411-2413 3 p.

Research output: Contribution to journal › Article › peer-review

Increased alpha cell to beta cell ratio in patients with pancreatic cancer

Tsuchiya, T., Saisho, Y., Inaishi, J., Sasaki, H., Sato, M., Nishikawa, M., Masugi, Y., Yamada, T. & Itoh, H., 2022, In: Endocrine journal. 69, 12, p. 1407-1414 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Intestinal Epithelial NAD⁺Biosynthesis Regulates GLP-1 Production and Postprandial Glucose Metabolism in Mice

Nagahisa, T., Yamaguchi, S., Kosugi, S., Homma, K., Miyashita, K., Irie, J., Yoshino, J. & Itoh, H., 2022 Apr 1, In: Endocrinology (United States). 163, 4, bqac023.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Late Dialysis Modality Education Could Negatively Predict Peritoneal Dialysis Selection

Nakayama, T., Nishioka, K., Uchiyama, K., Morimoto, K., Kusahana, E., Washida, N., Yamaguchi, S., Azegami, T., Yoshida, T. & Itoh, H., 2022 Jul, In: Journal of Clinical Medicine. 11, 14, 4042.

Research output: Contribution to journal › Article › peer-review

Open Access

Lysine-specific demethylase 1 as a corepressor of mineralocorticoid receptor

Kohata, N., Kurihara, I., Yokota, K., Kobayashi, S., Murai-Takeda, A., Mitsuishi, Y., Nakamura, T., Morisaki, M., Kozuma, T., Torimitsu, T., Kawai, M. & Itoh, H., 2022 Apr, In: Hypertension Research. 45, 4, p. 641-649 9 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Newly developed type 1 diabetes after coronavirus disease 2019 vaccination: A case report

Sasaki, H., Itoh, A., Watanabe, Y., Nakajima, Y., Saisho, Y., Irie, J., Meguro, S. & Itoh, H., 2022 Jun, In: Journal of Diabetes Investigation. 13, 6, p. 1105-1108 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Nicotinamide Mononucleotide Prevents Retinal Dysfunction in a Mouse Model of Retinal Ischemia/Reperfusion Injury

Lee, D., Tomita, Y., Miwa, Y., Shinojima, A., Ban, N., Yamaguchi, S., Nishioka, K., Negishi, K., Yoshino, J. & Kurihara, T., 2022 Oct, In: International journal of molecular sciences. 23, 19, 11228.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Nicotinamide Mononucleotide Protects against Retinal Dysfunction in a Murine Model of Carotid Artery Occlusion

Lee, D., Tomita, Y., Miwa, Y., Jeong, H., Shinojima, A., Ban, N., Yamaguchi, S., Nishioka, K., Negishi, K., Yoshino, J. & Kurihara, T., 2022 Dec, In: International journal of molecular sciences. 23, 23, 14711.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Prevalence of hypertensive diseases and treated hypertensive patients in Japan: A nationwide administrative claims database study

Waki, T., Miura, K., Tanaka-Mizuno, S., Ohya, Y., Node, K., Itoh, H., Rakugi, H., Sato, J., Goda, K., Kitsuregawa, M., Ishikawa, T. & Mitsutake, N., 2022 Jul, In: Hypertension Research. 45, 7, p. 1123-1133 11 p.

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Proximal-tubule molecular relay from early Protein diaphanous homolog 1 to late Rho-associated protein kinase 1 regulates kidney function in obesity-induced kidney damage

Ida-Naitoh, M., Tokuyama, H., Futatsugi, K., Yasuda, M., Adachi, K., Kanda, T., Tanabe, Y., Wakino, S. & Itoh, H., 2022, (Accepted/In press) In: Kidney international.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Self-assessment sheet submission rate predicts technique survival in patients initiating peritoneal dialysis

Kusahana, E., Uchiyama, K., Yamaguchi, N., Hirashima, M., Togashi, T., Yamamoto, Y., Imai, M., Ashida, M., Yamamura, K., Nakayama, T., Yasuda, I., Morimoto, K., Washida, N. & Itoh, H., 2022 Jun, In: Nephrology. 27, 6, p. 501-509 9 p.

Research output: Contribution to journal › Article › peer-review

Serial measurement of B-type natriuretic peptide and future cardiovascular events in patients with type 2 diabetes mellitus without known cardiovascular disease

Ikeda, S., Shinohara, K., Enzan, N., Matsushima, S., Tohyama, T., Funakoshi, K., Kishimoto, J., Itoh, H., Komuro, I. & Tsutsui, H., 2022 Jun 1, In: International Journal of Cardiology. 356, p. 98-104 7 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Serum thymus and activation-regulated chemokine level is associated with the severity of chronic kidney disease-associated pruritus in patients undergoing peritoneal dialysis

Nakayama, T., Morimoto, K., Uchiyama, K., Kusahana, E., Washida, N., Azegami, T., Kanda, T., Yoshida, T. & Itoh, H., 2022 Jul, In: Peritoneal Dialysis International. 42, 4, p. 415-424 10 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Small Dense Low-Density Lipoprotein Cholesterol is a Potential Marker for Predicting Laser Treatment for Retinopathy in Diabetic Patients

Nakayama, A., Morita, H., Sato, T., Kawahara, T., Takeda, N., Kato, S., Itoh, H. & Komuro, I., 2022, In: Journal of atherosclerosis and thrombosis. 29, 5, p. 678-691 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

The significance of NAD + metabolites and nicotinamide N-methyltransferase in chronic kidney disease

Takahashi, R., Kanda, T., Komatsu, M., Itoh, T., Minakuchi, H., Urai, H., Kuroita, T., Shigaki, S., Tsukamoto, T., Higuchi, N., Ikeda, M., Yamanaka, R., Yoshimura, N., Ono, T., Yukioka, H., Hasegawa, K., Tokuyama, H., Wakino, S. & Itoh, H., 2022 Dec, In: Scientific reports. 12, 1, 6398.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Usefulness of subclassification of adult diabetes mellitus among inpatients in Japan

Saito, K., Inoue, T., Ariyasu, H., Shimada, T., Itoh, H., Tanaka, I. & Terao, C., 2022 Apr, In: Journal of Diabetes Investigation. 13, 4, p. 706-713 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Vaccination against connective tissue growth factor attenuates the development of renal fibrosis

Nakayama, T., Azegami, T., Hayashi, K., Hishikawa, A., Yoshimoto, N., Nakamichi, R., Sugita, E. & Itoh, H., 2022 Dec, In: Scientific reports. 12, 1, 10933.

Research output: Contribution to journal › Article › peer-review

Open Access

Virtual management of hypertension: Lessons from the COVID-19 pandemic-International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension

Khan, N. A., Stergiou, G. S., Omboni, S., Kario, K., Renna, N., Chapman, N., McManus, R. J., Williams, B., Parati, G., Konradi, A., Islam, S. M., Itoh, H., Mooi, C. S., Green, B. B., Cho, M. C. & Tomaszewski, M., 2022 Aug 1, In: Journal of hypertension. 40, 8, p. 1435-1448 14 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

2021

A Case of New-Onset Systemic Lupus Erythematosus With Serositis in a Maintenance Hemodialysis Patient

Kosugi, S., Yoshida, T., Yoshimoto, N., Itoh, H. & Oya, M., 2021, In: Clinical Medicine Insights: Case Reports. 14

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Antihypertensive effects and safety of esaxerenone in patients with moderate kidney dysfunction

Ito, S., Itoh, H., Rakugi, H., Okuda, Y. & Iijima, S., 2021 May, In: Hypertension Research. 44, 5, p. 489-497 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Citations (Scopus)

Association between testosterone and lipid profiles under statin therapy and its clinical impact on the cardiovascular event risk

Nakayama, A., Morita, H., Kawahara, T., Itoh, H. & Komuro, I., 2021 Dec, In: Heart and vessels. 36, 12, p. 1794-1803 10 p.

Research output: Contribution to journal › Article › peer-review

Association of childhood anthropometric measurements and laboratory parameters with high blood pressure in young adults

Azegami, T., Uchida, K., Arima, F., Sato, Y., Awazu, M., Inokuchi, M., Murai-Takeda, A., Itoh, H., Tokumura, M. & Mori, M., 2021 Jun, In: Hypertension Research. 44, 6, p. 711-719 9 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Association of visit-to-visit glycemic variability with risk of cardiovascular diseases in high-risk Japanese patients with type 2 diabetes: A subanalysis of the EMPATHY trial

Sato, M., Inaishi, J., Saisho, Y., Sato, Y., Komuro, I. & Itoh, H., 2021 Dec, In: Journal of Diabetes Investigation. 12, 12, p. 2190-2196 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

Bullous pemphigoid in patients receiving peritoneal dialysis: a case series and a literature survey

Morimoto, K., Yoshida, T., Washida, N., Uchiyama, K., Nakayama, T., Itoh, H. & Oya, M., 2021, In: Renal Failure. 43, 1, p. 651-657 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Calcium phosphate microcrystals in the renal tubular fluid accelerate chronic kidney disease progression

Shiizaki, K., Tsubouchi, A., Miura, Y., Seo, K., Kuchimaru, T., Hayashi, H., Iwazu, Y., Miura, M., Battulga, B., Ohno, N., Hara, T., Kunishige, R., Masutani, M., Negishi, K., Kario, K., Kotani, K., Yamada, T., Nagata, D., Komuro, I., Itoh, H., & 3 othersKurosu, H., Murata, M. & Kuro-o, M., 2021 Aug 16, In: Journal of Clinical Investigation. 131, 16, e145693.

Research output: Contribution to journal › Article › peer-review

Open Access