Department of Internal Medicine (Pulmonary Medicine)

Research Output

2020

Anti-TSLP antibodies: Targeting a master regulator of type 2 immune responses

Nakajima, S., Kabata, H., Kabashima, K. & Asano, K., 2020 Apr, In : Allergology International. 69, 2, p. 197-203 7 p.

Research output: Contribution to journalReview article

Open Access
2 Citations (Scopus)

Characteristics of chronic obstructive pulmonary disease patients with pulmonary hypertension assessed by echocardiography in a three-year observational cohort study

Nakayama, S., Chubachi, S., Sakurai, K., Irie, H., Tsutsumi, A., Hashiguchi, M., Itabashi, Y., Murata, M., Nakamura, H., Asano, K. & Fukunaga, K., 2020 Jan 1, In : International Journal of COPD. 15, p. 487-499 13 p.

Research output: Contribution to journalArticle

Open Access
Open Access

Cysteinyl leukotriene metabolism of human eosinophils in allergic disease

Miyata, J., Fukunaga, K., Kawashima, Y., Ohara, O. & Arita, M., 2020 Jan, In : Allergology International. 69, 1, p. 28-34 7 p.

Research output: Contribution to journalReview article

Open Access
2 Citations (Scopus)

Evaluating serum periostin levels in allergic bronchopulmonary aspergillosis

Tanaka, J., Hebisawa, A., Oguma, T., Tomomatsu, K., Suzuki, J., Shimizu, H., Kawabata, Y., Ishiguro, T., Takayanagi, N., Ueda, S., Fukunaga, K., Taniguchi, M., Ono, J., Ohta, S., Izuhara, K. & Asano, K., 2020 Apr 1, In : Allergy: European Journal of Allergy and Clinical Immunology. 75, 4, p. 974-977 4 p.

Research output: Contribution to journalLetter

IGF2 Autocrine-mediated IGF1R activation is a clinically relevant mechanism of osimertinib resistance in Lung Cancer

Manabe, T., Yasuda, H., Terai, H., Kagiwa, H. D. A., Hamamoto, J., Ebisudani, T., Kobayashi, K., Masuzawa, K., Ikemura, S., Kawa, I. D. A., Hayashi, Y., Fukui, K., Horimoto, K., Fukunaga, K. & Soeji, K. M. A., 2020 Apr 1, In : Molecular Cancer Research. 18, 4, p. 549-559 11 p.

Research output: Contribution to journalArticle

Open Access

Sleep stage detection using only heart rate

Mitsukura, Y., Fukunaga, K., Yasui, M. & Mimura, M., 2020 Mar 1, In : Health Informatics Journal. 26, 1, p. 376-387 12 p.

Research output: Contribution to journalArticle

Targeted deletion of the TSLP receptor reveals cellular mechanisms that promote type 2 airway inflammation

Kabata, H., Flamar, A. L., Mahlakõiv, T., Moriyama, S., Rodewald, H. R., Ziegler, S. F. & Artis, D., 2020 Jan 1, (Accepted/In press) In : Mucosal Immunology.

Research output: Contribution to journalArticle

Open Access

Targeting Co-Occurring Genomic Alterations in MET Exon 14 Skipping Mutation-Positive NSCLC

Yasuda, H., 2020 May, In : Journal of Thoracic Oncology. 15, 5, p. 679-680 2 p.

Research output: Contribution to journalEditorial

Airway M Cells arise in the lower airway due to RANKL signaling and reside in the bronchiolar epithelium associated with iBALT in murine models of respiratory disease

Kimura, S., Mutoh, M., Hisamoto, M., Saito, H., Takahashi, S., Asakura, T., Ishii, M., Nakamura, Y., Iida, J., Hase, K. & Iwanaga, T., 2019 Jan 1, In : Frontiers in Immunology. 10, JUN, 1323.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Allergic bronchopulmonary aspergillosis in succession to chronic eosinophilic pneumonia

Mochimaru, T., Fukunaga, K., Ueda, S., Kuroda, A., Watanabe, R., Chubachi, S. & Betsuyaku, T., 2019 Jul 1, In : Allergology International. 68, 3, p. 370-371 2 p.

Research output: Contribution to journalLetter

Open Access

Analysis of the Influence of Lung Function Decline on Brain Function using Brain Healthcare Quotient

Watanabe, H., Fukunaga, K., Ikaga, T. & Mitsukura, Y., 2019 Oct, Proceedings: IECON 2019 - 45th Annual Conference of the IEEE Industrial Electronics Society. IEEE Computer Society, p. 5353-5357 5 p. 8927307. (IECON Proceedings (Industrial Electronics Conference); vol. 2019-October).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

A novel smoking cessation smartphone app integrated with a mobile carbon monoxide checker for smoking cessation treatment: Protocol for a randomized controlled trial

Nomura, A., Tateno, H., Masaki, K., Muto, T., Suzuki, S., Satake, K., Hida, E. & Fukunaga, K., 2019 Feb 1, In : Journal of medical Internet research. 21, 2, e12252.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

A phase II trial of induction of erlotinib followed by cytotoxic chemotherapy for EGFR mutation-positive non-squamous non-small cell lung cancer patients

Tani, T., Naoki, K., Yasuda, H., Arai, D., Ishioka, K., Ohgino, K., Yoda, S., Nakayama, S., Satomi, R., Terai, H., Ikemura, S., Sato, T. & Soejima, K., 2019 Jan 1, (Accepted/In press) In : Cancer Chemotherapy and Pharmacology.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A Therapeutic Strategy for All Pneumonia Patients: A 3-Year Prospective Multicenter Cohort Study Using Risk Factors for Multidrug-resistant Pathogens to Select Initial Empiric Therapy

Maruyama, T., Fujisawa, T., Ishida, T., Ito, A., Oyamada, Y., Fujimoto, K., Yoshida, M., Maeda, H., Miyashita, N., Nagai, H., Imamura, Y., Shime, N., Suzuki, S., Amishima, M., Higa, F., Kobayashi, H., Suga, S., Tsutsui, K., Kohno, S., Brito, V. & 1 others, Niederman, M. S., 2019 Mar 19, In : Clinical Infectious Diseases. 68, 7, p. 1080-1088 9 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Black pleural effusion caused by pancreatic pseudocyst rupture

Ishigaki, S., Kuwae, M., Ishii, M., Asakura, T., Ueda, S. & Betsuyaku, T., 2019 Feb 1, In : Clinical Case Reports. 7, 2, p. 385-386 2 p.

Research output: Contribution to journalArticle

Open Access

Calorie restriction enhances adult mouse lung stem cells function and reverses several ageing-induced changes

Hegab, A. E., Ozaki, M., Meligy, F. Y., Nishino, M., Kagawa, S., Ishii, M. & Betsuyaku, T., 2019 Feb 1, In : Journal of Tissue Engineering and Regenerative Medicine. 13, 2, p. 295-308 14 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Current state and future prospect of the therapeutic strategy targeting cysteinyl leukotriene metabolism in asthma

Yamamoto, T., Miyata, J., Arita, M., Fukunaga, K. & Kawana, A., 2019 Nov, In : Respiratory Investigation. 57, 6, p. 534-543 10 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Deficiency of CRTH2, a prostaglandin D 2 receptor, aggravates bleomycin-induced pulmonary inflammation and fibrosis

Ueda, S., Fukunaga, K., Takihara, T., Shiraishi, Y., Oguma, T., Shiomi, T., Suzuki, Y., Ishii, M., Sayama, K., Kagawa, S., Hirai, H., Nagata, K., Nakamura, M., Miyasho, T., Betsuyaku, T. & Asano, K., 2019 Mar 1, In : American journal of respiratory cell and molecular biology. 60, 3, p. 289-298 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Disseminated histoplasmosis from a calcified lung nodule after long-term corticosteroid therapy in an elderly Japanese patient: A case report

Kobayashi, K., Asakura, T., Kawada, I., Hasegawa, H., Chubachi, S., Ohara, K., Kuramoto, J., Sugiura, H., Fujishima, S., Iwata, S., Umeyama, T., Katano, H., Uwamino, Y., Miyazaki, Y., Kamei, K., Hasegawa, N. & Betsuyaku, T., 2019 Apr 1, In : Medicine. 98, 17, p. e15264

Research output: Contribution to journalArticle

Open Access

Dysregulated fatty acid metabolism in nasal polyp-derived eosinophils from patients with chronic rhinosinusitis

Miyata, J., Fukunaga, K., Kawashima, Y., Watanabe, T., Saitoh, A., Hirosaki, T., Araki, Y., Kikawada, T., Betsuyaku, T., Ohara, O. & Arita, M., 2019 Jun, In : Allergy: European Journal of Allergy and Clinical Immunology. 74, 6, p. 1113-1124 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Effect of FGF/FGFR pathway blocking on lung adenocarcinoma and its cancer-associated fibroblasts

Hegab, A. E., Ozaki, M., Kameyama, N., Gao, J., Kagawa, S., Yasuda, H., Soejima, K., Yin, Y., Guzy, R. D., Nakamura, Y., Ornitz, D. M. & Betsuyaku, T., 2019 Oct 1, In : Journal of Pathology. 249, 2, p. 193-205 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Efficacy of afatinib or osimertinib plus cetuximab combination therapy for non-small-cell lung cancer with EGFR exon 20 insertion mutations

Hasegawa, H., Yasuda, H., Hamamoto, J., Masuzawa, K., Tani, T., Nukaga, S., Hirano, T., Kobayashi, K., Manabe, T., Terai, H., Ikemura, S., Kawada, I., Naoki, K. & Soejima, K., 2019 Jan 1, In : Lung Cancer. 127, p. 146-152 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Factors associated with improvements in subjective symptoms of obstructive sleep apnea syndrome after continuous positive airway pressure therapy

Otsuka, K., Fukunaga, K., WakakoYamasawa, Haraguchi, M., Tani, T., Shirahama, R. & Betsuyaku, T., 2019 Jan 1, In : Sleep and Breathing.

Research output: Contribution to journalArticle

First report of hepatobiliary Mycobacterium avium infection developing obstructive jaundice in a patient with neutralizing anti–interferon-gamma autoantibodies

Namkoong, H., Asakura, T., Ishii, M., Yoda, S., Masaki, K., Sakagami, T., Iwasaki, E., Yamagishi, Y., Kanai, T., Betsuyaku, T. & Hasegawa, N., 2019 Jan 1, In : New Microbes and New Infections. 27, p. 4-6 3 p.

Research output: Contribution to journalArticle

Impact of a novel smartphone app (cureapp smoking cessation) on nicotine dependence: Prospective single-arm interventional pilot study

Masaki, K., Tateno, H., Kameyama, N., Morino, E., Watanabe, R., Sekine, K., Ono, T., Satake, K., Suzuki, S., Nomura, A., Betsuyaku, T. & Fukunaga, K., 2019 Feb 1, In : Journal of medical Internet research. 21, 2, e12694.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2

Zhou, L., Chu, C., Teng, F., Bessman, N. J., Goc, J., Santosa, E. K., Putzel, G. G., Kabata, H., Kelsen, J. R., Baldassano, R. N., Shah, M. A., Sockolow, R. E., Vivier, E., Eberl, G., Smith, K. A. & Sonnenberg, G. F., 2019 Apr 18, In : Nature. 568, 7752, p. 405-409 5 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Low serum estradiol levels are related to Mycobacterium avium complex lung disease: A cross-sectional study

Uwamino, Y., Nishimura, T., Sato, Y., Tamizu, E., Asakura, T., Uno, S., Mori, M., Fujiwara, H., Ishii, M., Kawabe, H., Murata, M. & Hasegawa, N., 2019 Dec 16, In : BMC infectious diseases. 19, 1, 1055.

Research output: Contribution to journalArticle

Open Access

Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations

Ikemura, S., Yasuda, H., Matsumoto, S., Kamada, M., Hamamoto, J., Masuzawa, K., Kobayashi, K., Manabe, T., Arai, D., Nakachi, I., Kawada, I., Ishioka, K., Nakamura, M., Namkoong, H., Naoki, K., Ono, F., Araki, M., Kanada, R., Ma, B., Hayashi, Y. & 8 others, Mimaki, S., Yoh, K., Kobayashi, S. S., Kohno, T., Okuno, Y., Goto, K., Tsuchihara, K. & Soejima, K., 2019 May 14, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10025-10030 6 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Monomer preference of EGFR tyrosine kinase inhibitors influences the synergistic efficacy of combination therapy with cetuximab

Oashi, A., Yasuda, H., Kobayashi, K., Tani, T., Hamamoto, J., Masuzawa, K., Manabe, T., Terai, H., Ikemura, S., Kawada, I., Naoki, K. & Soejima, K., 2019 Jan 1, In : Molecular cancer therapeutics. 18, 9, p. 1593-1601 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

MULTIOMICS ANALYSIS OF HUMAN EOSINOPHILS REVEALED MOLECULAR MECHANISM OF EOSINOPHILIC RHINOSINUSITIS AND SEVERE ASTHMA

Miyata, J., Kawashima, Y., Ohara, O., Betsuyaku, T., Fukunaga, K. & Arita, M., 2019 Jan 1, In : Arerugi = [Allergy]. 68, 2, p. 86-91 6 p.

Research output: Contribution to journalArticle

Neuro-immune crosstalk and allergic inflammation

Kabata, H. & Artis, D., 2019 Apr 1, In : Journal of Clinical Investigation. 129, 4, p. 1475-1482 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Neutrophil-to-lymphocyte ratio as a novel independent predictor of severe exacerbation in patients with asthma

Mochimaru, T., Ueda, S., Suzuki, Y., Asano, K. & Fukunaga, K., 2019 Jan 1, (Accepted/In press) In : Annals of Allergy, Asthma and Immunology.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Obesity worsens the outcome of influenza virus infection associated with impaired type I interferon induction in mice

Namkoong, H., Ishii, M., Fujii, H., Asami, T., Yagi, K., Suzuki, S., Azekawa, S., Tasaka, S., Hasegawa, N. & Betsuyaku, T., 2019 May 28, In : Biochemical and Biophysical Research Communications. 513, 2, p. 405-411 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Predictive and modifying factors of bone mineral density decline in patients with COPD

Kameyama, N., Chubachi, S., Sasaki, M., Tsutsumi, A., Irie, H., Sakurai, K., Sayama, K., Nakamura, H., Asano, K., Betsuyaku, T. & Fukunaga, K., 2019 Mar 1, In : Respiratory Medicine. 148, p. 13-23 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Prognostic values of the Berlin definition criteria, blood lactate level, and fibroproliferative changes on high-resolution computed tomography in ARDS patients

Kamo, T., Tasaka, S., Suzuki, T., Asakura, T., Suzuki, S., Yagi, K., Namkoong, H., Ishii, M., Morisaki, H. & Betsuyaku, T., 2019 Feb 11, In : BMC Pulmonary Medicine. 19, 1, 37.

Research output: Contribution to journalArticle

Open Access

Rare presentation of anaphylaxis: Pancake syndrome

Masaki, K., Fukunaga, K., Kawakami, Y. & Haque, R., 2019 Mar 1, In : BMJ case reports. 12, 3, e228854.

Research output: Contribution to journalArticle

Retrospective evaluation of natural course in mild cases of Mycobacterium avium complex pulmonary disease

for the Non-Tuberculous Mycobacteriosis-Japan Research Consortium (NTM-JRC), 2019 Apr 1, In : PloS one. 14, 4, e0216034.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Sitafloxacin-containing regimen for the treatment of refractory mycobacterium avium complex lung disease

Asakura, T., Suzuki, S., Fukano, H., Okamori, S., Kusumoto, T., Uwamino, Y., Ogawa, T., So, M., Uno, S., Namkoong, H., Yoshida, M., Kamata, H., Ishii, M., Nishimura, T., Hoshino, Y. & Hasegawa, N., 2019 Apr, In : Open Forum Infectious Diseases. 6, 4, ofz108.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

TAS6417/CLN-081 is a pan-mutation-selective EGFR tyrosine kinase inhibitor with a broad spectrum of preclinical activity against clinically relevant EGFR mutations

Udagawa, H., Hasako, S., Ohashi, A., Fujioka, R., Hakozaki, Y., Shibuya, M., Abe, N., Komori, T., Haruma, T., Terasaka, M., Fujita, R., Hashimoto, A., Funabashi, K., Yasuda, H., Miyadera, K., Goto, K., Costa, D. B. & Kobayashi, S. S., 2019 Jan 1, In : Molecular Cancer Research. 17, 11, p. 2233-2243 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

Anti-aminoacyl tRNA synthetase antibody-positive clinically amyopathic dermatomyositis

Ebisudani, T., Asakura, T., Ueda, S., Ishii, M. & Betsuyaku, T., 2018 Jun 1, In : QJM. 111, 6, p. 425-426 2 p.

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Anti-inflammatory roles of mesenchymal stromal cells during acute Streptococcus pneumoniae pulmonary infection in mice

Asami, T., Ishii, M., Namkoong, H., Yagi, K., Tasaka, S., Asakura, T., Suzuki, S., Kamo, T., Okamori, S., Kamata, H., Zhang, H., Hegab, A. E., Hasegawa, N. & Betsuyaku, T., 2018 Mar 1, In : Cytotherapy. 20, 3, p. 302-313 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Aspergillus precipitating antibody in patients with Mycobacterium avium complex lung disease: A cross-sectional study

Suzuki, S., Asakura, T., Namkoong, H., Okamori, S., Yagi, K., Kamata, H., Uwamino, Y., Funatsu, Y., Nakano, Y., Nishimura, T., Ishii, M., Ebihara, T., Betsuyaku, T. & Hasegawa, N., 2018 May, In : Respiratory Medicine. 138, p. 1-6 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Association between severity of obstructive sleep apnea and glycated hemoglobin level in japanese individuals with and without diabetes

Kurosawa, H., Saisho, Y., Fukunaga, K., Haraguchi, M., Yamasawa, W., Kurihara, I., Betsuyaku, T. & Itoh, H., 2018 Jan 1, In : Endocrine Journal. 65, 1, p. 121-127 7 p.

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Association between six-minute walk test parameters and the health-related quality of life in patients with pulmonary Mycobacterium avium complex disease

Yagi, K., Asakura, T., Namkoong, H., Suzuki, S., Asami, T., Okamori, S., Kusumoto, T., Funatsu, Y., Kamata, H., Nishimura, T., Ishii, M., Betsuyaku, T. & Hasegawa, N., 2018 Jul 13, In : BMC Pulmonary Medicine. 18, 1, 114.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Author's reply: Atrial fibrillation and sleep apnea: A chicken and egg situation

Kimura, T., Kohno, T., Fukunaga, K., Yamasawa, W., Fujisawa, T., Fukuoka, R., Nakajima, K., Kashimura, S., Kunitomi, A., Katsumata, Y., Nishiyama, T., Nishiyama, N., Aizawa, Y., Fukuda, K. & Takatsuki, S., 2018 Nov 1, In : International Journal of Cardiology. 270, 1 p.

Research output: Contribution to journalLetter

Bilateral upper lobe Pneumocystis pneumonia during aerosolized pentamidine prophylaxis

Ohara, Y., Asakura, T., Ueda, S., Yamada, Y., Ishii, M. & Betsuyaku, T., 2018 May 1, In : QJM. 111, 5, p. 337-338 2 p.

Research output: Contribution to journalArticle

Clarithromycin expands CD11b+Gr-1+cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia

Namkoong, H., Ishii, M., Fujii, H., Yagi, K., Asami, T., Asakura, T., Suzuki, S., Hegab, A. E., Kamata, H., Tasaka, S., Atarashi, K., Nakamoto, N., Iwata, S., Honda, K., Kanai, T., Hasegawa, N., Koyasu, S. & Betsuyaku, T., 2018 Apr 1, In : PLoS Pathogens. 14, 4, e1006955.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Clinical characteristics of pulmonary Mycobacterium lentiflavum disease in adult patients

Yagi, K., Morimoto, K., Ishii, M., Namkoong, H., Okamori, S., Asakura, T., Suzuki, S., Asami, T., Uwamino, Y., Funatsu, Y., Fujiwara, H., Kamata, H., Nishimura, T., Betsuyaku, T., Kurashima, A. & Hasegawa, N., 2018 Feb 1, In : International Journal of Infectious Diseases. 67, p. 65-69 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)