Department of Internal Medicine (Pulmonary Medicine)

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Article
2020

Characteristics of chronic obstructive pulmonary disease patients with pulmonary hypertension assessed by echocardiography in a three-year observational cohort study

Nakayama, S., Chubachi, S., Sakurai, K., Irie, H., Tsutsumi, A., Hashiguchi, M., Itabashi, Y., Murata, M., Nakamura, H., Asano, K. & Fukunaga, K., 2020 Jan 1, In : International Journal of COPD. 15, p. 487-499 13 p.

Research output: Contribution to journalArticle

Open Access

IGF2 Autocrine-mediated IGF1R activation is a clinically relevant mechanism of osimertinib resistance in Lung Cancer

Manabe, T., Yasuda, H., Terai, H., Kagiwa, H. D. A., Hamamoto, J., Ebisudani, T., Kobayashi, K., Masuzawa, K., Ikemura, S., Kawa, I. D. A., Hayashi, Y., Fukui, K., Horimoto, K., Fukunaga, K. & Soeji, K. M. A., 2020 Apr 1, In : Molecular Cancer Research. 18, 4, p. 549-559 11 p.

Research output: Contribution to journalArticle

Open Access

Sleep stage detection using only heart rate

Mitsukura, Y., Fukunaga, K., Yasui, M. & Mimura, M., 2020 Mar 1, In : Health Informatics Journal. 26, 1, p. 376-387 12 p.

Research output: Contribution to journalArticle

Targeted deletion of the TSLP receptor reveals cellular mechanisms that promote type 2 airway inflammation

Kabata, H., Flamar, A. L., Mahlakõiv, T., Moriyama, S., Rodewald, H. R., Ziegler, S. F. & Artis, D., 2020 Jan 1, (Accepted/In press) In : Mucosal Immunology.

Research output: Contribution to journalArticle

Open Access
2019

Airway M Cells arise in the lower airway due to RANKL signaling and reside in the bronchiolar epithelium associated with iBALT in murine models of respiratory disease

Kimura, S., Mutoh, M., Hisamoto, M., Saito, H., Takahashi, S., Asakura, T., Ishii, M., Nakamura, Y., Iida, J., Hase, K. & Iwanaga, T., 2019 Jan 1, In : Frontiers in Immunology. 10, JUN, 1323.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

A novel smoking cessation smartphone app integrated with a mobile carbon monoxide checker for smoking cessation treatment: Protocol for a randomized controlled trial

Nomura, A., Tateno, H., Masaki, K., Muto, T., Suzuki, S., Satake, K., Hida, E. & Fukunaga, K., 2019 Feb 1, In : Journal of medical Internet research. 21, 2, e12252.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

A phase II trial of induction of erlotinib followed by cytotoxic chemotherapy for EGFR mutation-positive non-squamous non-small cell lung cancer patients

Tani, T., Naoki, K., Yasuda, H., Arai, D., Ishioka, K., Ohgino, K., Yoda, S., Nakayama, S., Satomi, R., Terai, H., Ikemura, S., Sato, T. & Soejima, K., 2019 Jan 1, (Accepted/In press) In : Cancer Chemotherapy and Pharmacology.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A Therapeutic Strategy for All Pneumonia Patients: A 3-Year Prospective Multicenter Cohort Study Using Risk Factors for Multidrug-resistant Pathogens to Select Initial Empiric Therapy

Maruyama, T., Fujisawa, T., Ishida, T., Ito, A., Oyamada, Y., Fujimoto, K., Yoshida, M., Maeda, H., Miyashita, N., Nagai, H., Imamura, Y., Shime, N., Suzuki, S., Amishima, M., Higa, F., Kobayashi, H., Suga, S., Tsutsui, K., Kohno, S., Brito, V. & 1 others, Niederman, M. S., 2019 Mar 19, In : Clinical Infectious Diseases. 68, 7, p. 1080-1088 9 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Black pleural effusion caused by pancreatic pseudocyst rupture

Ishigaki, S., Kuwae, M., Ishii, M., Asakura, T., Ueda, S. & Betsuyaku, T., 2019 Feb 1, In : Clinical Case Reports. 7, 2, p. 385-386 2 p.

Research output: Contribution to journalArticle

Open Access

Calorie restriction enhances adult mouse lung stem cells function and reverses several ageing-induced changes

Hegab, A. E., Ozaki, M., Meligy, F. Y., Nishino, M., Kagawa, S., Ishii, M. & Betsuyaku, T., 2019 Feb 1, In : Journal of Tissue Engineering and Regenerative Medicine. 13, 2, p. 295-308 14 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Deficiency of CRTH2, a prostaglandin D 2 receptor, aggravates bleomycin-induced pulmonary inflammation and fibrosis

Ueda, S., Fukunaga, K., Takihara, T., Shiraishi, Y., Oguma, T., Shiomi, T., Suzuki, Y., Ishii, M., Sayama, K., Kagawa, S., Hirai, H., Nagata, K., Nakamura, M., Miyasho, T., Betsuyaku, T. & Asano, K., 2019 Mar 1, In : American journal of respiratory cell and molecular biology. 60, 3, p. 289-298 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Disseminated histoplasmosis from a calcified lung nodule after long-term corticosteroid therapy in an elderly Japanese patient: A case report

Kobayashi, K., Asakura, T., Kawada, I., Hasegawa, H., Chubachi, S., Ohara, K., Kuramoto, J., Sugiura, H., Fujishima, S., Iwata, S., Umeyama, T., Katano, H., Uwamino, Y., Miyazaki, Y., Kamei, K., Hasegawa, N. & Betsuyaku, T., 2019 Apr 1, In : Medicine. 98, 17, p. e15264

Research output: Contribution to journalArticle

Open Access

Dysregulated fatty acid metabolism in nasal polyp-derived eosinophils from patients with chronic rhinosinusitis

Miyata, J., Fukunaga, K., Kawashima, Y., Watanabe, T., Saitoh, A., Hirosaki, T., Araki, Y., Kikawada, T., Betsuyaku, T., Ohara, O. & Arita, M., 2019 Jun, In : Allergy: European Journal of Allergy and Clinical Immunology. 74, 6, p. 1113-1124 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Effect of FGF/FGFR pathway blocking on lung adenocarcinoma and its cancer-associated fibroblasts

Hegab, A. E., Ozaki, M., Kameyama, N., Gao, J., Kagawa, S., Yasuda, H., Soejima, K., Yin, Y., Guzy, R. D., Nakamura, Y., Ornitz, D. M. & Betsuyaku, T., 2019 Oct 1, In : Journal of Pathology. 249, 2, p. 193-205 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Efficacy of afatinib or osimertinib plus cetuximab combination therapy for non-small-cell lung cancer with EGFR exon 20 insertion mutations

Hasegawa, H., Yasuda, H., Hamamoto, J., Masuzawa, K., Tani, T., Nukaga, S., Hirano, T., Kobayashi, K., Manabe, T., Terai, H., Ikemura, S., Kawada, I., Naoki, K. & Soejima, K., 2019 Jan 1, In : Lung Cancer. 127, p. 146-152 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Factors associated with improvements in subjective symptoms of obstructive sleep apnea syndrome after continuous positive airway pressure therapy

Otsuka, K., Fukunaga, K., WakakoYamasawa, Haraguchi, M., Tani, T., Shirahama, R. & Betsuyaku, T., 2019 Jan 1, In : Sleep and Breathing.

Research output: Contribution to journalArticle

First report of hepatobiliary Mycobacterium avium infection developing obstructive jaundice in a patient with neutralizing anti–interferon-gamma autoantibodies

Namkoong, H., Asakura, T., Ishii, M., Yoda, S., Masaki, K., Sakagami, T., Iwasaki, E., Yamagishi, Y., Kanai, T., Betsuyaku, T. & Hasegawa, N., 2019 Jan 1, In : New Microbes and New Infections. 27, p. 4-6 3 p.

Research output: Contribution to journalArticle

Impact of a novel smartphone app (cureapp smoking cessation) on nicotine dependence: Prospective single-arm interventional pilot study

Masaki, K., Tateno, H., Kameyama, N., Morino, E., Watanabe, R., Sekine, K., Ono, T., Satake, K., Suzuki, S., Nomura, A., Betsuyaku, T. & Fukunaga, K., 2019 Feb 1, In : Journal of medical Internet research. 21, 2, e12694.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2

Zhou, L., Chu, C., Teng, F., Bessman, N. J., Goc, J., Santosa, E. K., Putzel, G. G., Kabata, H., Kelsen, J. R., Baldassano, R. N., Shah, M. A., Sockolow, R. E., Vivier, E., Eberl, G., Smith, K. A. & Sonnenberg, G. F., 2019 Apr 18, In : Nature. 568, 7752, p. 405-409 5 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Low serum estradiol levels are related to Mycobacterium avium complex lung disease: A cross-sectional study

Uwamino, Y., Nishimura, T., Sato, Y., Tamizu, E., Asakura, T., Uno, S., Mori, M., Fujiwara, H., Ishii, M., Kawabe, H., Murata, M. & Hasegawa, N., 2019 Dec 16, In : BMC infectious diseases. 19, 1, 1055.

Research output: Contribution to journalArticle

Open Access

Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations

Ikemura, S., Yasuda, H., Matsumoto, S., Kamada, M., Hamamoto, J., Masuzawa, K., Kobayashi, K., Manabe, T., Arai, D., Nakachi, I., Kawada, I., Ishioka, K., Nakamura, M., Namkoong, H., Naoki, K., Ono, F., Araki, M., Kanada, R., Ma, B., Hayashi, Y. & 8 others, Mimaki, S., Yoh, K., Kobayashi, S. S., Kohno, T., Okuno, Y., Goto, K., Tsuchihara, K. & Soejima, K., 2019 May 14, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10025-10030 6 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Monomer preference of EGFR tyrosine kinase inhibitors influences the synergistic efficacy of combination therapy with cetuximab

Oashi, A., Yasuda, H., Kobayashi, K., Tani, T., Hamamoto, J., Masuzawa, K., Manabe, T., Terai, H., Ikemura, S., Kawada, I., Naoki, K. & Soejima, K., 2019 Jan 1, In : Molecular cancer therapeutics. 18, 9, p. 1593-1601 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

MULTIOMICS ANALYSIS OF HUMAN EOSINOPHILS REVEALED MOLECULAR MECHANISM OF EOSINOPHILIC RHINOSINUSITIS AND SEVERE ASTHMA

Miyata, J., Kawashima, Y., Ohara, O., Betsuyaku, T., Fukunaga, K. & Arita, M., 2019 Jan 1, In : Arerugi = [Allergy]. 68, 2, p. 86-91 6 p.

Research output: Contribution to journalArticle

Neuro-immune crosstalk and allergic inflammation

Kabata, H. & Artis, D., 2019 Apr 1, In : Journal of Clinical Investigation. 129, 4, p. 1475-1482 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Neutrophil-to-lymphocyte ratio as a novel independent predictor of severe exacerbation in patients with asthma

Mochimaru, T., Ueda, S., Suzuki, Y., Asano, K. & Fukunaga, K., 2019 Jan 1, (Accepted/In press) In : Annals of Allergy, Asthma and Immunology.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Obesity worsens the outcome of influenza virus infection associated with impaired type I interferon induction in mice

Namkoong, H., Ishii, M., Fujii, H., Asami, T., Yagi, K., Suzuki, S., Azekawa, S., Tasaka, S., Hasegawa, N. & Betsuyaku, T., 2019 May 28, In : Biochemical and Biophysical Research Communications. 513, 2, p. 405-411 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Predictive and modifying factors of bone mineral density decline in patients with COPD

Kameyama, N., Chubachi, S., Sasaki, M., Tsutsumi, A., Irie, H., Sakurai, K., Sayama, K., Nakamura, H., Asano, K., Betsuyaku, T. & Fukunaga, K., 2019 Mar 1, In : Respiratory Medicine. 148, p. 13-23 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Prognostic values of the Berlin definition criteria, blood lactate level, and fibroproliferative changes on high-resolution computed tomography in ARDS patients

Kamo, T., Tasaka, S., Suzuki, T., Asakura, T., Suzuki, S., Yagi, K., Namkoong, H., Ishii, M., Morisaki, H. & Betsuyaku, T., 2019 Feb 11, In : BMC Pulmonary Medicine. 19, 1, 37.

Research output: Contribution to journalArticle

Open Access

Rare presentation of anaphylaxis: Pancake syndrome

Masaki, K., Fukunaga, K., Kawakami, Y. & Haque, R., 2019 Mar 1, In : BMJ case reports. 12, 3, e228854.

Research output: Contribution to journalArticle

Retrospective evaluation of natural course in mild cases of Mycobacterium avium complex pulmonary disease

for the Non-Tuberculous Mycobacteriosis-Japan Research Consortium (NTM-JRC), 2019 Apr 1, In : PloS one. 14, 4, e0216034.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Sitafloxacin-containing regimen for the treatment of refractory mycobacterium avium complex lung disease

Asakura, T., Suzuki, S., Fukano, H., Okamori, S., Kusumoto, T., Uwamino, Y., Ogawa, T., So, M., Uno, S., Namkoong, H., Yoshida, M., Kamata, H., Ishii, M., Nishimura, T., Hoshino, Y. & Hasegawa, N., 2019 Apr, In : Open Forum Infectious Diseases. 6, 4, ofz108.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

TAS6417/CLN-081 is a pan-mutation-selective EGFR tyrosine kinase inhibitor with a broad spectrum of preclinical activity against clinically relevant EGFR mutations

Udagawa, H., Hasako, S., Ohashi, A., Fujioka, R., Hakozaki, Y., Shibuya, M., Abe, N., Komori, T., Haruma, T., Terasaka, M., Fujita, R., Hashimoto, A., Funabashi, K., Yasuda, H., Miyadera, K., Goto, K., Costa, D. B. & Kobayashi, S. S., 2019 Jan 1, In : Molecular Cancer Research. 17, 11, p. 2233-2243 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

Anti-inflammatory roles of mesenchymal stromal cells during acute Streptococcus pneumoniae pulmonary infection in mice

Asami, T., Ishii, M., Namkoong, H., Yagi, K., Tasaka, S., Asakura, T., Suzuki, S., Kamo, T., Okamori, S., Kamata, H., Zhang, H., Hegab, A. E., Hasegawa, N. & Betsuyaku, T., 2018 Mar 1, In : Cytotherapy. 20, 3, p. 302-313 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Aspergillus precipitating antibody in patients with Mycobacterium avium complex lung disease: A cross-sectional study

Suzuki, S., Asakura, T., Namkoong, H., Okamori, S., Yagi, K., Kamata, H., Uwamino, Y., Funatsu, Y., Nakano, Y., Nishimura, T., Ishii, M., Ebihara, T., Betsuyaku, T. & Hasegawa, N., 2018 May, In : Respiratory Medicine. 138, p. 1-6 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Association between six-minute walk test parameters and the health-related quality of life in patients with pulmonary Mycobacterium avium complex disease

Yagi, K., Asakura, T., Namkoong, H., Suzuki, S., Asami, T., Okamori, S., Kusumoto, T., Funatsu, Y., Kamata, H., Nishimura, T., Ishii, M., Betsuyaku, T. & Hasegawa, N., 2018 Jul 13, In : BMC Pulmonary Medicine. 18, 1, 114.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Bilateral upper lobe Pneumocystis pneumonia during aerosolized pentamidine prophylaxis

Ohara, Y., Asakura, T., Ueda, S., Yamada, Y., Ishii, M. & Betsuyaku, T., 2018 May 1, In : QJM. 111, 5, p. 337-338 2 p.

Research output: Contribution to journalArticle

Clarithromycin expands CD11b+Gr-1+cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia

Namkoong, H., Ishii, M., Fujii, H., Yagi, K., Asami, T., Asakura, T., Suzuki, S., Hegab, A. E., Kamata, H., Tasaka, S., Atarashi, K., Nakamoto, N., Iwata, S., Honda, K., Kanai, T., Hasegawa, N., Koyasu, S. & Betsuyaku, T., 2018 Apr 1, In : PLoS Pathogens. 14, 4, e1006955.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Clinical characteristics of pulmonary Mycobacterium lentiflavum disease in adult patients

Yagi, K., Morimoto, K., Ishii, M., Namkoong, H., Okamori, S., Asakura, T., Suzuki, S., Asami, T., Uwamino, Y., Funatsu, Y., Fujiwara, H., Kamata, H., Nishimura, T., Betsuyaku, T., Kurashima, A. & Hasegawa, N., 2018 Feb 1, In : International Journal of Infectious Diseases. 67, p. 65-69 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Clinical characterization of rare EGFR mutations in non-small cell lung cancer and in silico prediction of drug sensitivity

Ikemura, S., Yasuda, H., Matsumoto, S., Kamada, M., Betsuyaku, T., Okuno, Y., Goto, K., Tsuchihara, K. & Soejima, K., 2018 Oct 1, In : Annals of oncology : official journal of the European Society for Medical Oncology. 29, p. viii513

Research output: Contribution to journalArticle

Open Access

Clinical utility of blood neutrophil-lymphocyte ratio in Japanese COPD patients

Sakurai, K., Chubachi, S., Irie, H., Tsutsumi, A., Kameyama, N., Kamatani, T., Koh, H., Terashima, T., Nakamura, H., Asano, K. & Betsuyaku, T., 2018 May 2, In : BMC Pulmonary Medicine. 18, 1, 65.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Comparison of detection methods of EGFR T790M mutations using plasma, serum, and tumor tissue in EGFR-TKI-resistant non-small cell lung cancer

Kobayashi, K., Naoki, K., Manabe, T., Masuzawa, K., Hasegawa, H., Yasuda, H., Kawada, I., Soejima, K. & Betsuyaku, T., 2018 Jun 6, In : OncoTargets and Therapy. 11, p. 3335-3343 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Development of lung cancer in patients with; nontuberculous mycobacterial lung disease

Kusumoto, T., Asakura, T., Suzuki, S., Okamori, S., Namkoong, H., Fujiwara, H., Yagi, K., Kamata, H., Ishii, M., Betsuyaku, T. & Hasegawa, N., 2018 Jan 1, (Accepted/In press) In : Respiratory Investigation.

Research output: Contribution to journalArticle

Development of necrotizing myopathy following interstitial lung disease with anti-signal recognition particle antibody

Kusumoto, T., Okamori, S., Masuzawa, K., Asakura, T., Nishina, N., Chubachi, S., Naoki, K., Fukunaga, K. & Betsuyaku, T., 2018 Jan 1, In : Internal Medicine. 57, 14, p. 2045-2049 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema

Sasaki, M., Chubachi, S., Kameyama, N., Sato, M., Haraguchi, M., Miyazaki, M., Takahashi, S., Nakano, T., Kuroda, Y., Betsuyaku, T. & Matsuo, K., 2018 Jan 1, In : PLoS One. 13, 1, e0191611.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Efficacy and safety of intermittent maintenance therapy after successful treatment of Mycobacterium avium complex lung disease

Nontuberculous Mycobacteriosis Japan Research Consortium (NTM-JRC), 2018 Jan 1, (Accepted/In press) In : Journal of Infection and Chemotherapy.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Egfr-mutant non-small cell lung cancer accompanied by transient asymptomatic pulmonary opacities successfully treated with “stop-and-go” osimertinib

Kobayashi, K., Naoki, K., Kuroda, A., Yasuda, H., Kawada, I., Soejima, K. & Betsuyaku, T., 2018 Jan 1, In : Internal Medicine. 57, 7, p. 1007-1010 4 p.

Research output: Contribution to journalArticle

Eosinophils and anti-inflammatory lipid mediators

Fukunaga, K., 2018 Jan 1, In : Japanese Journal of Allergology. 67, 1, p. 28-30 3 p.

Research output: Contribution to journalArticle

Health-related QOL of elderly patients with pulmonary M. avium complex disease in a university hospital

Asakura, T., Ishii, M., Ishii, K., Suzuki, S., Namkoong, H., Okamori, S., Kamata, H., Yagi, K., Funatsu, Y., Betsuyaku, T. & Hasegawa, N., 2018 Jun 1, In : International Journal of Tuberculosis and Lung Disease. 22, 6, p. 695-703 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

High fat diet activates adult mouse lung stem cells and accelerates several aging-induced effects

Hegab, A. E., Ozaki, M., Meligy, F. Y., Kagawa, S., Ishii, M. & Betsuyaku, T., 2018 Dec 1, In : Stem Cell Research. 33, p. 25-35 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Impact of cataract on health-related quality of life in a longitudinal Japanese chronic obstructive pulmonary cohort

On behalf of the Keio COPD Comorbidity Research (K-CCR) Group, 2018 Nov 1, In : Chronic Respiratory Disease. 15, 4, p. 329-338 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)