The Sakaguchi Laboratory of Developmental Biology Department of Organoid Medicine

Research Output 2000 2020

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2000

The role of IL-18 on the pathogenesis of Crohn's disease

Hibi, T., Kanai, T., Watanabe, M., Okazawa, S. & Sato, T., 2000, In : Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology. 23, 6, p. 607-610 4 p.

Research output: Contribution to journalArticle

Interleukin-18
Crohn Disease
2001
27 Citations (Scopus)

Interleukin-18 and Crohn's disease

Kanai, T., Watanabe, M., Okazawa, A., Sato, T. & Hibi, T., 2001, In : Digestion. 63, SUPPL. 1, p. 37-42 6 p.

Research output: Contribution to journalArticle

Interleukin-18
Crohn Disease
Macrophages
T-Lymphocytes
Intestinal Mucosa
148 Citations (Scopus)

Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease

Kanai, T., Watanabe, M., Okazawa, A., Sato, T., Yamazaki, M., Okamoto, S., Ishii, H., Totsuka, T., Iiyama, R., Okamoto, R., Ikeda, M., Kurimoto, M., Takeda, K., Akira, S. & Hibi, T., 2001, In : Gastroenterology. 121, 4, p. 875-888 14 p.

Research output: Contribution to journalArticle

Interleukin-18
Crohn Disease
Sulfonic Acids
Trinitrobenzenes
Macrophages
13 Citations (Scopus)

Restricted VH gene usage in lamina propria B cells producing anticolon antibody from patients with ulcerative colitis

Inoue, N., Watanabe, M., Sato, T., Okazawa, A., Yamazaki, M., Kanai, T., Ogata, H., Iwao, Y., Ishii, H. & Hibi, T., 2001, In : Gastroenterology. 121, 1, p. 15-23 9 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Mucous Membrane
B-Lymphocytes
Clone Cells
Antibodies
2004
42 Citations (Scopus)

Human intestinal epithelial cell-derived interleukin (IL)-18, along with IL2, IL-7 and IL-15, is a potent synergistic factor for the proliferation of intraepithelial lymphocytes

Okazawa, A., Kanai, T., Nakamaru, K., Sato, T., Inoue, N., Ogata, H., Iwao, Y., Ikeda, M., Kawamura, T., Makita, S., Uraushihara, K., Okamoto, R., Yamazaki, M., Kurimoto, M., Ishii, H., Watanabe, M. & Hibi, T., 2004 May, In : Clinical and Experimental Immunology. 136, 2, p. 269-276 8 p.

Research output: Contribution to journalArticle

Interleukin-15
Interleukin-7
Interleukin-18
Interleukin-2
Epithelial Cells
35 Citations (Scopus)

Hyperexpression of Inducible Costimulator and Its Contribution on Lamina Propria T Cells in Inflammatory Bowel Disease

Sato, T., Kanai, T., Watanabe, M., Sakuraba, A., Okamoto, S., Nakai, T., Okazawa, A., Inoue, N., Totsuka, T., Yamazaki, M., Kroczek, R. A., Fukushima, T., Ishii, H. & Hibi, T., 2004 Mar, In : Gastroenterology. 126, 3, p. 829-839 11 p.

Research output: Contribution to journalArticle

Inducible T-Cell Co-Stimulator Protein
Inflammatory Bowel Diseases
Mucous Membrane
T-Lymphocytes
Ulcerative Colitis
103 Citations (Scopus)

T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction or Th1 mediated immunopathology in Crohn's disease

Matsuoka, K., Inoue, N., Sato, T., Okamoto, S., Hisamatsu, T., Kishi, Y., Sakuraba, A., Hitotsumatsu, O., Ogata, H., Koganei, K., Fukushima, T., Kanai, T., Watanabe, M., Ishii, H. & Hibi, T., 2004 Sep, In : Gut. 53, 9, p. 1303-1308 6 p.

Research output: Contribution to journalArticle

Interleukin-12
Crohn Disease
Up-Regulation
T-Lymphocytes
Mucous Membrane
2005
164 Citations (Scopus)

Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria

Kamada, N., Hisamatsu, T., Okamoto, S., Sato, T., Matsuoka, K., Arai, K., Nakai, T., Hasegawa, A., Inoue, N., Watanabe, N., Akagawa, K. S. & Hibi, T., 2005 Nov 15, In : Journal of Immunology. 175, 10, p. 6900-6908 9 p.

Research output: Contribution to journalArticle

Interleukin-23
Colitis
Interleukin-12
Interleukin-10
Macrophages
52 Citations (Scopus)

Nonpathogenic Escherichia coli strain Nissle 1917 prevents murine acute and chronic colitis

Kamada, N., Inoue, N., Hisamatsu, T., Okamoto, S., Matsuoka, K., Sato, T., Chinen, H., Hong, K. S., Yamada, T., Suzuki, Y., Suzuki, T., Watanabe, N., Tsuchimoto, K. & Hibi, T., 2005 May, In : Inflammatory Bowel Diseases. 11, 5, p. 455-463 9 p.

Research output: Contribution to journalArticle

Colitis
Escherichia coli
Therapeutic Uses
Dextran Sulfate
Hot Temperature
100 Citations (Scopus)

Osteopontin/Eta-1 upregulated in Crohn's disease regulates the Th1 immune response

Sato, T., Nakai, T., Tamura, N., Okamoto, S., Matsuoka, K., Sakuraba, A., Fukushima, T., Uede, T. & Hibi, T., 2005 Sep, In : Gut. 54, 9, p. 1254-1262 9 p.

Research output: Contribution to journalArticle

Osteopontin
Crohn Disease
Mucous Membrane
Ulcerative Colitis
Integrins
2006
46 Citations (Scopus)

Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis

Morohoshi, Y., Matsuoka, K., Chinen, H., Kamada, N., Sato, T., Hisamatsu, T., Okamoto, S., Inoue, N., Takaishi, H., Ogata, H., Iwao, Y. & Hibi, T., 2006 Apr, In : Journal of Gastroenterology. 41, 4, p. 318-324 7 p.

Research output: Contribution to journalArticle

Leukocyte Elastase
Dextran Sulfate
Colitis
Ulcerative Colitis
Mucous Membrane
2007
142 Citations (Scopus)

Cytomegalovirus is frequently reactivated and disappears without antiviral agents in ulcerative colitis patients

Matsuoka, K., Iwao, Y., Mori, T., Sakuraba, A., Yajima, T., Hisamatsu, T., Okamoto, S., Morohoshi, Y., Izumiya, M., Ichikawa, H., Sato, T., Inoue, N., Ogata, H. & Hibi, T., 2007 Feb, In : American Journal of Gastroenterology. 102, 2, p. 331-337 7 p.

Research output: Contribution to journalArticle

Cytomegalovirus
Ulcerative Colitis
Antiviral Agents
Immunoglobulin G
Colectomy
2008
26 Citations (Scopus)
Blood Component Removal
Ulcerative Colitis
Granulocytes
Adsorption
Monocytes
376 Citations (Scopus)

Unique CD14+ intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis

Kamada, N., Hisamatsu, T., Okamoto, S., Chinen, H., Kobayashi, T., Sato, T., Sakuraba, A., Kitazume, M. T., Sugita, A., Koganei, K., Akagawa, K. S. & Hibi, T., 2008 Jun 2, In : Journal of Clinical Investigation. 118, 6, p. 2269-2280 12 p.

Research output: Contribution to journalArticle

Interleukin-23
Crohn Disease
Macrophages
Mucous Membrane
Cytokines
2009
10 Citations (Scopus)

Granulocyte and monocyte adsorption apheresis therapy modulates monocyte-derived dendritic cell function in patients with ulcerative colitis

Iwakami, Y., Sakuraba, A., Sato, T., Takada, Y., Izumiya, M., Ichikawa, H. & Hibi, T., 2009 Apr, In : Therapeutic Apheresis and Dialysis. 13, 2, p. 138-146 9 p.

Research output: Contribution to journalArticle

Blood Component Removal
Ulcerative Colitis
Granulocytes
Dendritic Cells
Adsorption
145 Citations (Scopus)

Th1/Th17 Immune Response Is Induced by Mesenteric Lymph Node Dendritic Cells in Crohn's Disease

Sakuraba, A., Sato, T., Kamada, N., Kitazume, M., Sugita, A. & Hibi, T., 2009 Nov, In : Gastroenterology. 137, 5, p. 1736-1745 10 p.

Research output: Contribution to journalArticle

Crohn Disease
Dendritic Cells
Lymph Nodes
Myeloid Cells
Ulcerative Colitis
2011
352 Citations (Scopus)

Isolation and in vitro expansion of human colonic stem cells

Jung, P., Sato, T., Merlos-Suárez, A., Barriga, F. M., Iglesias, M., Rossell, D., Auer, H., Gallardo, M., Blasco, M. A., Sancho, E., Clevers, H. & Batlle, E., 2011 Oct, In : Nature Medicine. 17, 10, p. 1225-1227 3 p.

Research output: Contribution to journalArticle

Eph Family Receptors
Stem cells
Stem Cells
Stem Cell Niche
Biopsy
2012
5 Citations (Scopus)

CCR9+ macrophages are required for eradication of peritoneal bacterial infections and prevention of polymicrobial sepsis

Mizukami, T., Kanai, T., Mikami, Y., Hayashi, A., Doi, T., Handa, T., Matsumoto, A., Jun, L., Matsuoka, K., Sato, T., Hisamatsu, T. & Hibi, T., 2012 Sep, In : Immunology Letters. 147, 1-2, p. 75-79 5 p.

Research output: Contribution to journalArticle

Bacterial Infections
Sepsis
Peritoneal Macrophages
Macrophages
Punctures
169 Citations (Scopus)

Controlled gene expression in primary Lgr5 organoid cultures

Koo, B. K., Stange, D. E., Sato, T., Karthaus, W., Farin, H. F., Huch, M., Van Es, J. H. & Clevers, H., 2012 Jan, In : Nature Methods. 9, 1, p. 81-83 3 p.

Research output: Contribution to journalArticle

Organoids
Retroviridae
Cell culture
Gene expression
Small Intestine
402 Citations (Scopus)

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5 + stem cell

Yui, S., Nakamura, T., Sato, T., Nemoto, Y., Mizutani, T., Zheng, X., Ichinose, S., Nagaishi, T., Okamoto, R., Tsuchiya, K., Clevers, H. & Watanabe, M., 2012 Apr, In : Nature Medicine. 18, 4, p. 618-623 6 p.

Research output: Contribution to journalArticle

Adult Stem Cells
Stem cells
Colon
Epithelium
Organoids
7 Citations (Scopus)

Intermittent Granulocyte and Monocyte Apheresis Versus Mercaptopurine for Maintaining Remission of Ulcerative Colitis: A Pilot Study

Sakuraba, A., Sato, T., Morohoshi, Y., Matsuoka, K., Okamoto, S., Inoue, N., Takaishi, H., Ogata, H., Iwao, Y. & Hibi, T., 2012 Jun, In : Therapeutic Apheresis and Dialysis. 16, 3, p. 213-218 6 p.

Research output: Contribution to journalArticle

6-Mercaptopurine
Blood Component Removal
Ulcerative Colitis
Granulocytes
Adsorption
49 Citations (Scopus)

On the biomechanics of stem cell niche formation in the gut - Modelling growing organoids

Buske, P., Przybilla, J., Loeffler, M., Sachs, N., Sato, T., Clevers, H. & Galle, J., 2012 Sep, In : FEBS Journal. 279, 18, p. 3475-3487 13 p.

Research output: Contribution to journalArticle

Organoids
Stem Cell Niche
Biomechanics
Stem cells
Biomechanical Phenomena
2013
102 Citations (Scopus)

A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice

Hayashi, A., Sato, T., Kamada, N., Mikami, Y., Matsuoka, K., Hisamatsu, T., Hibi, T., Roers, A., Yagita, H., Ohteki, T., Yoshimura, A. & Kanai, T., 2013 Jun 12, In : Cell Host and Microbe. 13, 6, p. 711-722 12 p.

Research output: Contribution to journalArticle

Clostridium butyricum
Colitis
Interleukin-10
Macrophages
Mucous Membrane

Dendritic cells administered intrarectally penetrate the intestinal barrier to break intestinal tolerance via Th2-medeiated colitis in mice

Handa, T., Kanai, T., Sato, T., Mikami, Y., Sujino, T., Hayashi, A., Mizuno, S., Matsumoto, A., Hisamatsu, T. & Hibi, T., 2013 Feb, In : Immunology Letters. 150, 1-2, p. 123-129 7 p.

Research output: Contribution to journalArticle

Colitis
Dendritic Cells
Bone Marrow
Immune Tolerance
Antigen Presentation
13 Citations (Scopus)

Establishment of novel prediction system of intestinal absorption in humans using human intestinal tissues

Miyake, M., Toguchi, H., Nishibayashi, T., Higaki, K., Sugita, A., Koganei, K., Kamada, N., Kitazume, M. T., Hisamatsu, T., Sato, T., Okamoto, S., Kanai, T. & Hibi, T., 2013 Aug, In : Journal of Pharmaceutical Sciences. 102, 8, p. 2564-2571 8 p.

Research output: Contribution to journalArticle

Intestinal Absorption
Pharmaceutical Preparations
Metoprolol
Atenolol
Ulcerative Colitis
20 Citations (Scopus)

IL-22-Producing RORγt-Dependent Innate Lymphoid Cells Play a Novel Protective Role in Murine Acute Hepatitis

Matsumoto, A., Kanai, T., Mikami, Y., Cho, H., Nakamoto, N., Ebinuma, H., Saito, H., Sato, T., Yagita, H. & Hibi, T., 2013 Apr 23, In : PLoS One. 8, 4, e62853.

Research output: Contribution to journalArticle

hepatitis
Liver
Hepatitis
T-cells
Lymphocytes
613 Citations (Scopus)

In vitro expansion of single Lgr5 + liver stem cells induced by Wnt-driven regeneration

Huch, M., Dorrell, C., Boj, S. F., Van Es, J. H., Li, V. S. W., Van De Wetering, M., Sato, T., Hamer, K., Sasaki, N., Finegold, M. J., Haft, A., Vries, R. G., Grompe, M. & Clevers, H., 2013 Feb 14, In : Nature. 494, 7436, p. 247-250 4 p.

Research output: Contribution to journalArticle

Organoids
Regeneration
Stem Cells
Liver
Bile Ducts
33 Citations (Scopus)

Mucosal healing with oral tacrolimus is associated with favorable medium- and long-term prognosis in steroid-refractory/dependent ulcerative colitis patients

Miyoshi, J., Matsuoka, K., Inoue, N., Hisamatsu, T., Ichikawa, R., Yajima, T., Okamoto, S., Naganuma, M., Sato, T., Kanai, T., Ogata, H., Iwao, Y. & Hibi, T., 2013 Dec 15, In : Journal of Crohn's and Colitis. 7, 12

Research output: Contribution to journalArticle

Tacrolimus
Ulcerative Colitis
Steroids
Remission Induction
Colectomy

Spur cell anemia associated with alcoholic cirrhosis

Sugimoto, S., Yamagishi, Y., Ebinuma, H. & Kanai, T., 2013, In : Internal Medicine. 52, 24, p. 2831 1 p.

Research output: Contribution to journalArticle

Acanthocytes
Alcoholic Liver Cirrhosis
Hemolytic Anemia
Liver Failure
Anemia
67 Citations (Scopus)

TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease

Yoneno, K., Hisamatsu, T., Shimamura, K., Kamada, N., Ichikawa, R., Kitazume, M. T., Mori, M., Uo, M., Namikawa, Y., Matsuoka, K., Sato, T., Koganei, K., Sugita, A., Kanai, T. & Hibi, T., 2013 May, In : Immunology. 139, 1, p. 19-29 11 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Crohn Disease
Mucous Membrane
Macrophages
Cytokines
267 Citations (Scopus)

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

Huch, M., Bonfanti, P., Boj, S. F., Sato, T., Loomans, C. J. M., Van De Wetering, M., Sojoodi, M., Li, V. S. W., Schuijers, J., Gracanin, A., Ringnalda, F., Begthel, H., Hamer, K., Mulder, J., Van Es, J. H., De Koning, E., Vries, R. G. J., Heimberg, H. & Clevers, H., 2013 Oct 16, In : EMBO Journal. 32, 20, p. 2708-2721 14 p.

Research output: Contribution to journalArticle

Organoids
Ducts
Pancreas
Stem cells
Stem Cells
2014
3 Citations (Scopus)

Classical Th1 cells obtain colitogenicity by co-existence of RORγt-expressing T cells in experimental colitis

Saigusa, K., Hisamatsu, T., Handa, T., Sujino, T., Mikami, Y., Hayashi, A., Mizuno, S., Takeshita, K., Sato, T., Matsuoka, K. & Kanai, T., 2014 Oct 1, In : Inflammatory Bowel Diseases. 20, 10, p. 1820-1827 8 p.

Research output: Contribution to journalArticle

Th1 Cells
Colitis
T-Lymphocytes
Th17 Cells
Cell Count
5 Citations (Scopus)

Continuous low-dose irradiation by I-125 seeds induces apoptosis of gastric cancer cells regardless of histological origin

Takabayashi, K., Kashiwagi, K., Kawata, T., Sato, T., Matsuoka, K., Hisamatsu, T., Takaishi, H., Hibi, T., Ogata, H., Yahagi, N., Kitagawa, Y., Shigematsu, N. & Kanai, T., 2014 Jan, In : Cancer Biology and Therapy. 15, 1, p. 81-88 8 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Seeds
Apoptosis
In Situ Nick-End Labeling
Heterografts
36 Citations (Scopus)

Cross-talk between RORγt + innate lymphoid cells and intestinal macrophages induces mucosal IL-22 production In Crohn's disease

Mizuno, S., Mikami, Y., Kamada, N., Handa, T., Hayashi, A., Sato, T., Matsuoka, K., Matano, M., Ohta, Y., Sugita, A., Koganei, K., Sahara, R., Takazoe, M., Hisamatsu, T. & Kanai, T., 2014, In : Inflammatory Bowel Diseases. 20, 8, p. 1426-1434 9 p.

Research output: Contribution to journalArticle

Crohn Disease
Macrophages
Lymphocytes
interleukin-22
Mucous Membrane
7 Citations (Scopus)

Effectiveness and clinical results of endoscopic management of sigmoid volvulus using unsedated water-immersion colonoscopy

Sugimoto, S., Hosoe, N., Mizukami, T., Tsunoda, Y., Ito, T., Imamura, S., Tamura, T., Nagakubo, S., Morohoshi, Y., Koike, Y., Fujita, Y., Komatsu, H., Ogata, H. & Kanai, T., 2014, In : Digestive Endoscopy. 26, 4, p. 564-568 5 p.

Research output: Contribution to journalArticle

Intestinal Volvulus
Sigmoid Colon
Immersion
Colonoscopy
Water

Endoscopic ultrasound-guided drainage for a mediastinal pancreatic pseudocyst

Sugimoto, S., Yamagishi, Y., Higuchi, H. & Kanai, T., 2014, In : Internal Medicine. 53, 22, p. 2651-2652 2 p.

Research output: Contribution to journalArticle

Interventional Ultrasonography
Alcoholic Pancreatitis
Pancreatic Pseudocyst
Mediastinum
Pleural Effusion
32 Citations (Scopus)

KLF5 regulates the integrity and oncogenicity of intestinal stem cells

Nakaya, T., Ogawa, S., Manabe, I., Tanaka, M., Sanada, M., Sato, T., Taketo, M. M., Nakao, K., Clevers, H., Fukayama, M., Kuroda, M. & Nagai, R., 2014 May 15, In : Cancer Research. 74, 10, p. 2882-2891 10 p.

Research output: Contribution to journalArticle

Stem Cells
Catenins
Colorectal Neoplasms
Intestinal Neoplasms
Induced Pluripotent Stem Cells
9 Citations (Scopus)

Macrophages and dendritic cells emerge in the liver during intestinal inflammation and predispose the liver to inflammation

Mikami, Y., Mizuno, S., Nakamoto, N., Hayashi, A., Sujino, T., Sato, T., Kamada, N., Matsuoka, K., Hisamatsu, T., Ebinuma, H., Hibi, T., Yoshimura, A. & Kanai, T., 2014 Jan 2, In : PLoS One. 9, 1, e84619.

Research output: Contribution to journalArticle

Macrophages
dendritic cells
Liver
Dendritic Cells
macrophages
42 Citations (Scopus)

Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2

Simmini, S., Bialecka, M., Huch, M., Kester, L., Van De Wetering, M., Sato, T., Beck, F., Van Oudenaarden, A., Clevers, H. & Deschamps, J., 2014, In : Nature Communications. 5, 6728.

Research output: Contribution to journalArticle

stem cells
Stem cells
Stomach
Transcription Factors
Stem Cells
2015
13 Citations (Scopus)

An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epithelium

Pin, C., Parker, A., Gunning, A. P., Ohta, Y., Johnson, I. T., Carding, S. R. & Sato, T., 2015 Feb 1, In : Integrative Biology (United Kingdom). 7, 2, p. 213-228 16 p.

Research output: Contribution to journalArticle

Organoids
Intestinal Mucosa
Paneth Cells
Growth
Stem cells
7 Citations (Scopus)

Combination therapy with infliximab and thiopurine compared to infliximab monotherapy in maintaining remission of postoperative crohn's disease

Sakuraba, A., Okamoto, S., Matsuoka, K., Sato, T., Naganuma, M., Hisamatsu, T., Iwao, Y., Ogata, H., Kanai, T. & Hibi, T., 2015 May 6, In : Digestion. 91, 3, p. 233-238 6 p.

Research output: Contribution to journalArticle

Crohn Disease
Recurrence
Therapeutics
Infliximab
Remission Induction
63 Citations (Scopus)

Efficient genetic engineering of human intestinal organoids using electroporation

Fujii, M., Matano, M., Nanki, K. & Sato, T., 2015 Oct 29, In : Nature Protocols. 10, 10, p. 1474-1485 12 p.

Research output: Contribution to journalArticle

Organoids
Genetic engineering
Genetic Engineering
Electroporation
Genes
10 Citations (Scopus)

Ink4a/arf-dependent loss of parietal cells induced by oxidative stress promotes CD44-dependent gastric tumorigenesis

Seishima, R., Wada, T., Tsuchihashi, K., Okazaki, S., Yoshikawa, M., Oshima, H., Oshima, M., Sato, T., Hasegawa, H., Kitagawa, Y., Goldenring, J. R., Saya, H. & Nagano, O., 2015 Jun 1, In : Cancer Prevention Research. 8, 6, p. 492-501 10 p.

Research output: Contribution to journalArticle

Stomach
Carcinogenesis
Oxidative Stress
Reactive Oxygen Species
Metaplasia
63 Citations (Scopus)

Mini-Gut Organoids: Reconstitution of the Stem Cell Niche

Date, S. & Sato, T., 2015 Nov 13, In : Annual Review of Cell and Developmental Biology. 31, p. 269-289 21 p.

Research output: Contribution to journalArticle

Organoids
Stem Cell Niche
Stem Cells
Carcinogenesis
Epithelium
360 Citations (Scopus)

Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids

Matano, M., Date, S., Shimokawa, M., Takano, A., Fujii, M., Ohta, Y., Watanabe, T., Kanai, T. & Sato, T., 2015, In : Nature Medicine. 21, 3, p. 256-262 7 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Organoids
Human Engineering
Tumors
Colorectal Neoplasms
6 Citations (Scopus)

Recognition of and recent issues in hereditary diffuse gastric cancer

Sugimoto, S., Komatsu, H., Morohoshi, Y. & Kanai, T., 2015 Jun 7, In : Journal of Gastroenterology. 50, 8, p. 831-843 13 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Genetic Testing
Mutation
Organoids
Breast Neoplasms
39 Citations (Scopus)

Suppressing TGFβ signaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer

Oshima, H., Nakayama, M., Han, T. S., Naoi, K., Ju, X., Maeda, Y., Robine, S., Tsuchiya, K., Sato, T., Sato, H., Taketo, M. M. & Oshima, M., 2015 Feb 15, In : Cancer Research. 75, 4, p. 766-776 11 p.

Research output: Contribution to journalArticle

Intestinal Neoplasms
Epithelium
Epithelial Cells
Dextran Sulfate
Intestinal Mucosa
2016
162 Citations (Scopus)

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

Fujii, M., Shimokawa, M., Date, S., Takano, A., Matano, M., Nanki, K., Ohta, Y., Toshimitsu, K., Nakazato, Y., Kawasaki, K., Uraoka, T., Watanabe, T., Kanai, T. & Sato, T., 2016 Jun 2, In : Cell Stem Cell. 18, 6, p. 827-838 12 p.

Research output: Contribution to journalArticle

Organoids
Colorectal Neoplasms
Carcinogenesis
Transcriptome
Heterografts
47 Citations (Scopus)

Active and water-soluble form of lipidated wnt protein is maintained by a serum glycoprotein afamin/α-albumin

Mihara, E., Hirai, H., Yamamoto, H., Tamura-Kawakami, K., Matano, M., Kikuchi, A., Sato, T. & Takagi, J., 2016 Feb 23, In : eLife. 5, FEBRUARY2016, e11621.

Research output: Contribution to journalArticle

Wnt Proteins
Colony-Forming Units Assay
Detergents
Albumins
Assays
33 Citations (Scopus)

Clinical Efficacy and Safety of Oral Qing-Dai in Patients with Ulcerative Colitis: A Single-Center Open-Label Prospective Study

Sugimoto, S., Naganuma, M., Kiyohara, H., Arai, M., Ono, K., Mori, K., Saigusa, K., Nanki, K., Takeshita, K., Takeshita, T., Mutaguchi, M., Mizuno, S., Bessho, R., Nakazato, Y., Hisamatsu, T., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2016 Mar 10, (Accepted/In press) In : Digestion. p. 193-201 9 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Prospective Studies
Safety
Indigo Carmine
Occult Blood