• 40326 Citations
  • 105 h-Index
1982 …2020

Research output per year

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Research Output

2020

E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases

Wang, Z., Zhao, M., Yin, J., Liu, L., Hu, L., Huang, Y., Liu, A., Ouyang, J., Min, X., Rao, S., Zhou, W., Wu, H., Yoshimura, A. & Lu, Q., 2020 Jul 1, In : The Journal of clinical investigation. 130, 7, p. 3717-3733 17 p.

Research output: Contribution to journalArticle

Open Access

Identification of novel genes associated with dysregulation of B cells in patients with primary Sjögren's syndrome

Inamo, J., Suzuki, K., Takeshita, M., Kassai, Y., Takiguchi, M., Kurisu, R., Okuzono, Y., Tasaki, S., Tasaki, S., Yoshimura, A. & Takeuchi, T., 2020 Jun 22, In : Arthritis Research and Therapy. 22, 1, 153.

Research output: Contribution to journalArticle

Open Access

In Vitro Generation of Stem Cell Memory-Like T Cells from Activated T Cells

Ando, M., Ikeda, M., Yoshimura, A. & Kondo, T., 2020 Jan 1, Methods in Molecular Biology. Humana Press Inc., p. 127-139 13 p. (Methods in Molecular Biology; vol. 2111).

Research output: Chapter in Book/Report/Conference proceedingChapter

Regulatory T cells: Pathophysiological roles and clinical applications

Sakai, R., Komai, K., Iizuka-Koga, M., Yoshimura, A. & Ito, M., 2020 Jan 1, In : Keio Journal of Medicine. 69, 1, p. 1-15 15 p.

Research output: Contribution to journalReview article

Open Access

TGF-β-induced epigenetic deregulation of SOCS3 facilitates STAT3 signaling to promote fibrosis

Dees, C., Pötter, S., Zhang, Y., Bergmann, C., Zhou, X., Luber, M., Wohlfahrt, T., Karouzakis, E., Ramming, A., Gelse, K., Yoshimura, A., Jaenisch, R., Distler, O., Schett, G. & Distler, J. H. W., 2020 May 1, In : Journal of Clinical Investigation. 130, 5, p. 2347-2363 17 p.

Research output: Contribution to journalArticle

Open Access

The liver–brain–gut neural arc maintains the Treg cell niche in the gut

Teratani, T., Mikami, Y., Nakamoto, N., Suzuki, T., Harada, Y., Okabayashi, K., Hagihara, Y., Taniki, N., Kohno, K., Sibata, S., Miyamoto, K., Ishigame, H., Chu, P. S., Sujino, T., Suda, W., Hattori, M., Matsui, M., Okada, T., Okano, H., Inoue, M. & 7 others, Yada, T., Kitagawa, Y., Yoshimura, A., Tanida, M., Tsuda, M., Iwasaki, Y. & Kanai, T., 2020, (Accepted/In press) In : Nature.

Research output: Contribution to journalArticle

The NOTCH–FOXM1 axis plays a key role in mitochondrial biogenesis in the induction of human stem cell memory–like CAR-T cells

Kondo, T., Ando, M., Nagai, N., Tomisato, W., Srirat, T., Liu, B., Mise-Omata, S., Ikeda, M., Chikuma, S., Nishimasu, H., Nureki, O., Ohmura, M., Hayakawa, N., Hishiki, T., Uchibori, R., Ozawa, K. & Yoshimura, A., 2020 Feb 1, In : Cancer Research. 80, 3, p. 471-483 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2019

Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery

Ito, M., Komai, K., Mise-Omata, S., Iizuka-Koga, M., Noguchi, Y., Kondo, T., Sakai, R., Matsuo, K., Nakayama, T., Yoshie, O., Nakatsukasa, H., Chikuma, S., Shichita, T. & Yoshimura, A., 2019 Jan 10, In : Nature. 565, 7738, p. 246-250 5 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Chu, P. S., Taniki, N., Yamaguchi, A., Kanamori, M., Kamada, N., Hattori, M., Ashida, H., Sakamoto, M., Atarashi, K., Narushima, S., Yoshimura, A., Honda, K. & 2 others, Sato, T. & Kanai, T., 2019 Mar 1, In : Nature Microbiology. 4, 3, p. 492-503 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

In Vitro Conversion of Activated T Cells into Stem Cell Memory-Like T Cells

Kondo, T., Imura, Y., Ando, M., Chikuma, S. & Yoshimura, A., 2019 Jan 1, Methods in Molecular Biology. Humana Press Inc., p. 41-51 11 p. (Methods in Molecular Biology; vol. 2048).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression

Nakatsukasa, H., Oda, M., Yin, J., Chikuma, S., Ito, M., Koga-Iizuka, M., Someya, K., Kitagawa, Y., Ohkura, N., Sakaguchi, S., Koya, I., Sanosaka, T., Kohyama, J., Tsukada, Y. I., Yamanaka, S., Takamura-Enya, T., Lu, Q. & Yoshimura, A., 2019 Jan 1, In : International immunology. 31, 5, p. 335-347 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Memory T cell, exhaustion, and tumor immunity

Ando, M., Ito, M., Srirat, T., Kondo, T. & Yoshimura, A., 2019 Jan 1, (Accepted/In press) In : Immunological Medicine.

Research output: Contribution to journalReview article

Open Access

mir-181A/B-1 controls thymic selection of treg cells and tunes their suppressive capacity

Łyszkiewicz, M., Winter, S. J., Witzlau, K., Föhse, L., Brownlie, R., Puchałka, J., Verheyden, N. A., Kunze-Schumacher, H., Imelmann, E., Blume, J., Raha, S., Sekiya, T., Yoshimura, A., Frueh, J. T., Ullrich, E., Huehn, J., Weiss, S., Gutierrez, M. G., Prinz, I., Zamoyska, R. & 2 others, Ziętara, N. & Krueger, A., 2019 Mar, In : PLoS biology. 17, 3, e2006716.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Multi-dimensional analysis identified rheumatoid arthritis-driving pathway in human T cell

Takeshita, M., Suzuki, K., Kondo, Y., Morita, R., Okuzono, Y., Koga, K., Kassai, Y., Gamo, K., Takiguchi, M., Kurisu, R., Mototani, H., Ebisuno, Y., Yoshimura, A. & Takeuchi, T., 2019 Jan 1, In : Annals of the rheumatic diseases.

Research output: Contribution to journalArticle

2 Citations (Scopus)

NR4A transcription factors limit CAR T cell function in solid tumours

Chen, J., López-Moyado, I. F., Seo, H., Lio, C. W. J., Hempleman, L. J., Sekiya, T., Yoshimura, A., Scott-Browne, J. P. & Rao, A., 2019 Mar 28, In : Nature. 567, 7749, p. 530-534 5 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection

Fujiwara, S., Hoshizaki, M., Ichida, Y., Lex, D., Kuroda, E., Ishii, K. J., Magi, S., Okada, M., Takao, H., Gandou, M., Imai, H., Hara, R., Herzog, H., Yoshimura, A., Okamura, H., Penninger, J. M., Slutsky, A. S., Uhlig, S., Kuba, K. & Imai, Y., 2019 Feb 1, In : Nature Microbiology. 4, 2, p. 258-268 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Significant association between joint ultrasonographic parameters and synovial inflammatory factors in rheumatoid arthritis

Kondo, Y., Suzuki, K., Inoue, Y., Sakata, K., Takahashi, C., Takeshita, M., Kassai, Y., Miyazaki, T., Morita, R., Niki, Y., Kaneko, Y., Yasuoka, H., Yamaoka, K., Yoshimura, A. & Takeuchi, T., 2019 Oct 1, In : Arthritis Research and Therapy. 21, 1, 14.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Tissue regulatory T cells and neural repair

Ito, M., Komai, K., Nakamura, T., Srirat, T. & Yoshimura, A., 2019 Feb 19, In : International immunology. 31, 6, p. 361-369 9 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2018

Development and Functional Modulation of Regulatory T Cells by Transcription Factors and Epigenetics

Ito, M., Iizuka-Koga, M., Ando, M. & Yoshimura, A., 2018 Nov 1, In : Cornea. 37, p. S42-S49

Research output: Contribution to journalReview article

1 Citation (Scopus)

Generation and application of human induced-stem cell memory T cells for adoptive immunotherapy

Kondo, T., Imura, Y., Chikuma, S., Hibino, S., Omata-Mise, S., Ando, M., Akanuma, T., Iizuka, M., Sakai, R., Morita, R. & Yoshimura, A., 2018 Jul, In : Cancer science. 109, 7, p. 2130-2140 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse

Oike, T., Kanagawa, H., Sato, Y., Kobayashi, T., Nakatsukasa, H., Miyamoto, K., Nakamura, S., Kaneko, Y., Kobayashi, S., Harato, K., Yoshimura, A., Iwakura, Y., Takeuchi, T., Matsumoto, M., Nakamura, M., Niki, Y. & Miyamoto, T., 2018 Dec 1, In : Scientific Reports. 8, 1, 15783.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Inhibition of Nr4a receptors enhances antitumor immunity by breaking treg-mediated immune tolerance

Hibino, S., Chikuma, S., Kondo, T., Ito, M., Nakatsukasa, H., Omata-Mise, S. & Yoshimura, A., 2018 Jun 1, In : Cancer Research. 78, 11, p. 3027-3040 14 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission

Tasaki, S., Suzuki, K., Kassai, Y., Takeshita, M., Murota, A., Kondo, Y., Ando, T., Nakayama, Y., Okuzono, Y., Takiguchi, M., Kurisu, R., Miyazaki, T., Yoshimoto, K., Yasuoka, H., Yamaoka, K., Morita, R., Yoshimura, A., Toyoshiba, H. & Takeuchi, T., 2018 Dec 1, In : Nature Communications. 9, 1, 2755.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Negative regulation of cytokine signaling in immunity

Yoshimura, A., Ito, M., Chikuma, S., Akanuma, T. & Nakatsukasa, H., 2018 Jul, In : Cold Spring Harbor Perspectives in Biology. 10, 7, a028571.

Research output: Contribution to journalArticle

24 Citations (Scopus)

NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation

Kimura, A., Kitajima, M., Nishida, K., Serada, S., Fujimoto, M., Naka, T., Fujii-Kuriyama, Y., Sakamato, S., Ito, T., Handa, H., Tanaka, T., Yoshimura, A. & Suzuki, H., 2018 Sep 1, In : Journal of Experimental Medicine. 215, 8, p. 2197-2209 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Nr4a Receptors Regulate Development and Death of Labile Treg Precursors to Prevent Generation of Pathogenic Self-Reactive Cells

Sekiya, T., Hibino, S., Saeki, K., Kanamori, M., Takaki, S. & Yoshimura, A., 2018 Aug 7, In : Cell Reports. 24, 6, p. 1627-1638.e6

Research output: Contribution to journalArticle

3 Citations (Scopus)

Pivotal role of innate myeloid cells in cerebral post-ischemic sterile inflammation

Tsuyama, J., Nakamura, A., Ooboshi, H., Yoshimura, A. & Shichita, T., 2018 Nov 1, In : Seminars in Immunopathology. 40, 6, p. 523-538 16 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)

Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3

Tanaka, K., Martinez, G. J., Yan, X., Long, W., Ichiyama, K., Chi, X., Kim, B. S., Reynolds, J. M., Chung, Y., Tanaka, S., Liao, L., Nakanishi, Y., Yoshimura, A., Zheng, P., Wang, X., Tian, Q., Xu, J., O'Malley, B. W. & Dong, C., 2018 May 22, In : Cell Reports. 23, 8, p. 2318-2329 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Reprogramming of Th1 cells into regulatory T cells through rewiring of the metabolic status

Kanamori, M., Nakatsukasa, H., Ito, M., Chikuma, S. & Yoshimura, A., 2018 Jan 1, In : International Immunology. 30, 8, p. 357-373 17 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress

Tadokoro, Y., Hoshii, T., Yamazaki, S., Eto, K., Ema, H., Kobayashi, M., Ueno, M., Ohta, K., Arai, Y., Hara, E., Harada, K., Oshima, M., Oshima, H., Arai, F., Yoshimura, A., Nakauchi, H. & Hirao, A., 2018 May 3, In : Cell stem cell. 22, 5, p. 713-725.e8

Research output: Contribution to journalArticle

6 Citations (Scopus)

STAT3 expression by myeloid cells is detrimental for the T- cell-mediated control of infection with Mycobacterium tuberculosis

Gao, Y., Basile, J. I., Classon, C., Gavier-Widen, D., Yoshimura, A., Carow, B. & Rottenberg, M. E., 2018 Jan, In : PLoS Pathogens. 14, 1, e1006809.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The mechanism underlying the resolution of sterile inflammation through scavenger receptor

Shchita, T. & Yoshimura, A., 2018 Jan 1, In : Seikagaku. 90, 1, p. 99-102 4 p.

Research output: Contribution to journalReview article

2017

A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium

Eritja, N., Felip, I., Dosil, M. A., Vigezzi, L., Mirantes, C., Yeramian, A., Navaridas, R., Santacana, M., Llobet-Navas, D., Yoshimura, A., Nomura, M., Encinas, M., Matias-Guiu, X. & Dolcet, X., 2017 Aug 1, In : Cell Death and Differentiation. 24, 8, p. 1443-1458 16 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells

Okada, M., Chikuma, S., Kondo, T., Hibino, S., Machiyama, H., Yokosuka, T., Nakano, M. & Yoshimura, A., 2017 Aug 1, In : Cell Reports. 20, 5, p. 1017-1028 12 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Brain Micro-Inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit

Arima, Y., Ohki, T., Nishikawa, N., Higuchi, K., Ota, M., Tanaka, Y., Nio-Kobayashi, J., Elfeky, M., Sakai, R., Mori, Y., Kawamoto, T., Stofkova, A., Sakashita, Y., Morimoto, Y., Kuwatani, M., Iwanaga, T., Yoshioka, Y., Sakamoto, N., Yoshimura, A., Takiguchi, M. & 4 others, Sakoda, S., Prinz, M., Kamimura, D. & Murakami, M., 2017 Aug 15, In : eLife. 6, e25517.

Research output: Contribution to journalArticle

13 Citations (Scopus)

CISH controls bacterial burden early after infection with Mycobacterium tuberculosis in mice

Carow, B., Gao, Y., Terán, G., Yang, X. O., Dong, C., Yoshimura, A. & Rottenberg, M. E., 2017 Dec 1, In : Tuberculosis. 107, p. 175-180 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

E3 ubiquitin ligases SIAH1/2 regulate hypoxiainducible factor-1 (HIF-1)-mediated Th17 cell differentiation

Matsui-Hasumi, A., Sato, Y., Uto-Konomi, A., Yamashita, S., Uehori, J., Yoshimura, A., Yamashita, M., Asahara, H., Suzuki, S. & Kubo, M., 2017 Mar 1, In : International immunology. 29, 3, p. 133-143 11 p., dxx014.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Generation of allo-antigen-specific induced Treg stabilized by vitamin C treatment and its application for prevention of acute graft versus host disease model

Kasahara, H., Kondo, T., Nakatsukasa, H., Chikuma, S., Ito, M., Ando, M., Kurebayashi, Y., Sekiya, T., Yamada, T., Okamoto, S. & Yoshimura, A., 2017 Oct 1, In : International Immunology. 29, 10, p. 457-469 13 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

High-mobility group box 1 is an important mediator of microglial activation induced by cortical spreading depression

Takizawa, T., Shibata, M., Kayama, Y., Shimizu, T., Toriumi, H., Ebine, T., Unekawa, M., Koh, A., Yoshimura, A. & Suzuki, N., 2017 Mar 1, In : Journal of Cerebral Blood Flow and Metabolism. 37, 3, p. 890-901 12 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation

Someya, K., Nakatsukasa, H., Ito, M., Kondo, T., Tateda, K. I., Akanuma, T., Koya, I., Sanosaka, T., Kohyama, J., Tsukada, Y. I., Takamura-Enya, T. & Yoshimura, A., 2017 Aug 1, In : International Immunology. 29, 8, p. 365-375 11 p., dxx049.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Induction and maintenance of regulatory T cells by transcription factors and epigenetic modifications

Iizuka-Koga, M., Nakatsukasa, H., Ito, M., Akanuma, T., Lu, Q. & Yoshimura, A., 2017 Sep 1, In : Journal of Autoimmunity. 83, p. 113-121 9 p.

Research output: Contribution to journalReview article

20 Citations (Scopus)

MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1

Shichita, T., Ito, M., Morita, R., Komai, K., Noguchi, Y., Ooboshi, H., Koshida, R., Takahashi, S., Kodama, T. & Yoshimura, A., 2017 Jun 1, In : Nature medicine. 23, 6, p. 723-732 10 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Mechanistic insights into ectodomain shedding: Susceptibility of CADM1 adhesion molecule is determined by alternative splicing and O-glycosylation

Shirakabe, K., Omura, T., Shibagaki, Y., Mihara, E., Homma, K., Kato, Y., Yoshimura, A., Murakami, Y., Takagi, J., Hattori, S. & Ogawa, Y., 2017 Apr 10, In : Scientific reports. 7, 46174.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjögren's syndrome

Tasaki, S., Suzuki, K., Nishikawa, A., Kassai, Y., Takiguchi, M., Kurisu, R., Okuzono, Y., Miyazaki, T., Takeshita, M., Yoshimoto, K., Yasuoka, H., Yamaoka, K., Ikeura, K., Tsunoda, K., Morita, R., Yoshimura, A., Toyoshiba, H. & Takeuchi, T., 2017 Aug 1, In : Annals of the Rheumatic Diseases. 76, 8, p. 1458-1466 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling

Queval, C. J., Song, O. R., Carralot, J. P., Saliou, J. M., Bongiovanni, A., Deloison, G., Deboosère, N., Jouny, S., Iantomasi, R., Delorme, V., Debrie, A. S., Park, S. J., Gouveia, J. C., Tomavo, S., Brosch, R., Yoshimura, A., Yeramian, E. & Brodin, P., 2017 Sep 26, In : Cell Reports. 20, 13, p. 3188-3198 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy

Kondo, T., Morita, R., Okuzono, Y., Nakatsukasa, H., Sekiya, T., Chikuma, S., Shichita, T., Kanamori, M., Kubo, M., Koga, K., Miyazaki, T., Kassai, Y. & Yoshimura, A., 2017 May 22, In : Nature Communications. 8, 15338.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Role of scavenger receptors as damage-associated molecular pattern receptors in Toll-like receptor activation

Komai, K., Shichita, T., Ito, M., Kanamori, M., Chikuma, S. & Yoshimura, A., 2017, In : International Immunology. 29, 2, p. 59-70 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

SOCS1 is a key molecule that prevents regulatory T cell plasticity under inflammatory conditions

Takahashi, R., Nakatsukasa, H., Shiozawa, S. & Yoshimura, A., 2017 Jul 1, In : Journal of Immunology. 199, 1, p. 149-158 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Stabilization of Foxp3 expression by CRISPR-dCas9-based epigenome editing in mouse primary T cells

Okada, M., Kanamori, M., Someya, K., Nakatsukasa, H. & Yoshimura, A., 2017 May 8, In : Epigenetics and Chromatin. 10, 1, 24.

Research output: Contribution to journalArticle

38 Citations (Scopus)

STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization

Kitai, Y., Iwakami, M., Saitoh, K., Togi, S., Isayama, S., Sekine, Y., Muromoto, R., Kashiwakura, J. I., Yoshimura, A., Oritani, K. & Matsuda, T., 2017 Nov 24, In : Journal of Biological Chemistry. 292, 47, p. 19392-19399 8 p.

Research output: Contribution to journalArticle