• 39360 Citations
  • 104 h-Index
1982 …2019

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Article
2019

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Cho, H., Taniki, N., Yamaguchi, A., Kanamori, M., Kamada, N., Hattori, M., Ashida, H., Sakamoto, M., Atarashi, K., Narushima, S., Yoshimura, A., Honda, K. & 2 others, Sato, T. & Kanai, T., 2019 Jan 1, (Accepted/In press) In : Nature Microbiology.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression

Nakatsukasa, H., Oda, M., Yin, J., Chikuma, S., Ito, M., Koga-Iizuka, M., Someya, K., Kitagawa, Y., Ohkura, N., Sakaguchi, S., Koya, I., Sanosaka, T., Kohyama, J., Tsukada, Y. I., Yamanaka, S., Takamura-Enya, T., Lu, Q. & Yoshimura, A., 2019 Jan 1, In : International immunology. 31, 5, p. 335-347 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

mir-181A/B-1 controls thymic selection of treg cells and tunes their suppressive capacity

Łyszkiewicz, M., Winter, S. J., Witzlau, K., Föhse, L., Brownlie, R., Puchałka, J., Verheyden, N. A., Kunze-Schumacher, H., Imelmann, E., Blume, J., Raha, S., Sekiya, T., Yoshimura, A., Frueh, J. T., Ullrich, E., Huehn, J., Weiss, S., Gutierrez, M. G., Prinz, I., Zamoyska, R. & 2 others, Ziętara, N. & Krueger, A., 2019 Mar 1, In : PLoS Biology. 17, 3, e2006716.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Multi-dimensional analysis identified rheumatoid arthritis-driving pathway in human T cell

Takeshita, M., Suzuki, K., Kondo, Y., Morita, R., Okuzono, Y., Koga, K., Kassai, Y., Gamo, K., Takiguchi, M., Kurisu, R., Mototani, H., Ebisuno, Y., Yoshimura, A. & Takeuchi, T., 2019 Jan 1, In : Annals of the rheumatic diseases.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Significant association between joint ultrasonographic parameters and synovial inflammatory factors in rheumatoid arthritis

Kondo, Y., Suzuki, K., Inoue, Y., Sakata, K., Takahashi, C., Takeshita, M., Kassai, Y., Miyazaki, T., Morita, R., Niki, Y., Kaneko, Y., Yasuoka, H., Yamaoka, K., Yoshimura, A. & Takeuchi, T., 2019 Oct 1, In : Arthritis Research and Therapy. 21, 1, 14.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Tissue regulatory T cells and neural repair

Ito, M., Komai, K., Nakamura, T., Srirat, T. & Yoshimura, A., 2019 May 21, In : International immunology. 31, 6, p. 361-369 9 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Generation and application of human induced-stem cell memory T cells for adoptive immunotherapy

Kondo, T., Imura, Y., Chikuma, S., Hibino, S., Omata-Mise, S., Ando, M., Akanuma, T., Iizuka, M., Sakai, R., Morita, R. & Yoshimura, A., 2018 Jul 1, In : Cancer Science. 109, 7, p. 2130-2140 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse

Oike, T., Kanagawa, H., Sato, Y., Kobayashi, T., Nakatsukasa, H., Miyamoto, K., Nakamura, S., Kaneko, Y., Kobayashi, S., Harato, K., Yoshimura, A., Iwakura, Y., Takeuchi, T., Matsumoto, M., Nakamura, M., Niki, Y. & Miyamoto, T., 2018 Dec 1, In : Scientific Reports. 8, 1, 15783.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Inhibition of Nr4a receptors enhances antitumor immunity by breaking treg-mediated immune tolerance

Hibino, S., Chikuma, S., Kondo, T., Ito, M., Nakatsukasa, H., Omata-Mise, S. & Yoshimura, A., 2018 Jun 1, In : Cancer Research. 78, 11, p. 3027-3040 14 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission

Tasaki, S., Suzuki, K., Kassai, Y., Takeshita, M., Murota, A., Kondo, Y., Ando, T., Nakayama, Y., Okuzono, Y., Takiguchi, M., Kurisu, R., Miyazaki, T., Yoshimoto, K., Yasuoka, H., Yamaoka, K., Morita, R., Yoshimura, A., Toyoshiba, H. & Takeuchi, T., 2018 Dec 1, In : Nature Communications. 9, 1, 2755.

Research output: Contribution to journalArticle

18 Citations (Scopus)
22 Citations (Scopus)

NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation

Kimura, A., Kitajima, M., Nishida, K., Serada, S., Fujimoto, M., Naka, T., Fujii-Kuriyama, Y., Sakamato, S., Ito, T., Handa, H., Tanaka, T., Yoshimura, A. & Suzuki, H., 2018 Sep 1, In : Journal of Experimental Medicine. 215, 8, p. 2197-2209 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Nr4a Receptors Regulate Development and Death of Labile Treg Precursors to Prevent Generation of Pathogenic Self-Reactive Cells

Sekiya, T., Hibino, S., Saeki, K., Kanamori, M., Takaki, S. & Yoshimura, A., 2018 Aug 7, In : Cell Reports. 24, 6, p. 1627-1638.e6

Research output: Contribution to journalArticle

1 Citation (Scopus)

Pivotal role of innate myeloid cells in cerebral post-ischemic sterile inflammation

Tsuyama, J., Nakamura, A., Ooboshi, H., Yoshimura, A. & Shichita, T., 2018 Jan 1, (Accepted/In press) In : Seminars in Immunopathology.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection

Fujiwara, S., Hoshizaki, M., Ichida, Y., Lex, D., Kuroda, E., Ishii, K. J., Magi, S., Okada, M., Takao, H., Gandou, M., Imai, H., Hara, R., Herzog, H., Yoshimura, A., Okamura, H., Penninger, J. M., Slutsky, A. S., Uhlig, S., Kuba, K. & Imai, Y., 2018 Jan 1, (Accepted/In press) In : Nature Microbiology.

Research output: Contribution to journalArticle

Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3

Tanaka, K., Martinez, G. J., Yan, X., Long, W., Ichiyama, K., Chi, X., Kim, B. S., Reynolds, J. M., Chung, Y., Tanaka, S., Liao, L., Nakanishi, Y., Yoshimura, A., Zheng, P., Wang, X., Tian, Q., Xu, J., O'Malley, B. W. & Dong, C., 2018 May 22, In : Cell Reports. 23, 8, p. 2318-2329 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Reprogramming of Th1 cells into regulatory T cells through rewiring of the metabolic status

Kanamori, M., Nakatsukasa, H., Ito, M., Chikuma, S. & Yoshimura, A., 2018 Jan 1, In : International Immunology. 30, 8, p. 357-373 17 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress

Tadokoro, Y., Hoshii, T., Yamazaki, S., Eto, K., Ema, H., Kobayashi, M., Ueno, M., Ohta, K., Arai, Y., Hara, E., Harada, K., Oshima, M., Oshima, H., Arai, F., Yoshimura, A., Nakauchi, H. & Hirao, A., 2018 May 3, In : Cell Stem Cell. 22, 5, p. 713-725.e8

Research output: Contribution to journalArticle

5 Citations (Scopus)

STAT3 expression by myeloid cells is detrimental for the T- cell-mediated control of infection with Mycobacterium tuberculosis

Gao, Y., Basile, J. I., Classon, C., Gavier-Widen, D., Yoshimura, A., Carow, B. & Rottenberg, M. E., 2018 Jan 1, In : PLoS Pathogens. 14, 1, e1006809.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2017

A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium

Eritja, N., Felip, I., Dosil, M. A., Vigezzi, L., Mirantes, C., Yeramian, A., Navaridas, R., Santacana, M., Llobet-Navas, D., Yoshimura, A., Nomura, M., Encinas, M., Matias-Guiu, X. & Dolcet, X., 2017 Aug 1, In : Cell Death and Differentiation. 24, 8, p. 1443-1458 16 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells

Okada, M., Chikuma, S., Kondo, T., Hibino, S., Machiyama, H., Yokosuka, T., Nakano, M. & Yoshimura, A., 2017 Aug 1, In : Cell Reports. 20, 5, p. 1017-1028 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Brain Micro-Inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit

Arima, Y., Ohki, T., Nishikawa, N., Higuchi, K., Ota, M., Tanaka, Y., Nio-Kobayashi, J., Elfeky, M., Sakai, R., Mori, Y., Kawamoto, T., Stofkova, A., Sakashita, Y., Morimoto, Y., Kuwatani, M., Iwanaga, T., Yoshioka, Y., Sakamoto, N., Yoshimura, A., Takiguchi, M. & 4 others, Sakoda, S., Prinz, M., Kamimura, D. & Murakami, M., 2017 Aug 15, In : eLife. 6, e25517.

Research output: Contribution to journalArticle

12 Citations (Scopus)

CISH controls bacterial burden early after infection with Mycobacterium tuberculosis in mice

Carow, B., Gao, Y., Terán, G., Yang, X. O., Dong, C., Yoshimura, A. & Rottenberg, M. E., 2017 Dec 1, In : Tuberculosis. 107, p. 175-180 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

E3 ubiquitin ligases SIAH1/2 regulate hypoxiainducible factor-1 (HIF-1)-mediated Th17 cell differentiation

Matsui-Hasumi, A., Sato, Y., Uto-Konomi, A., Yamashita, S., Uehori, J., Yoshimura, A., Yamashita, M., Asahara, H., Suzuki, S. & Kubo, M., 2017 Mar 1, In : International Immunology. 29, 3, p. 133-143 11 p., dxx014.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Generation of allo-antigen-specific induced Treg stabilized by vitamin C treatment and its application for prevention of acute graft versus host disease model

Kasahara, H., Kondo, T., Nakatsukasa, H., Chikuma, S., Ito, M., Ando, M., Kurebayashi, Y., Sekiya, T., Yamada, T., Okamoto, S. & Yoshimura, A., 2017 Oct 1, In : International Immunology. 29, 10, p. 457-469 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

High-mobility group box 1 is an important mediator of microglial activation induced by cortical spreading depression

Takizawa, T., Shibata, M., Kayama, Y., Shimizu, T., Toriumi, H., Ebine, T., Unekawa, M., Koh, A., Yoshimura, A. & Suzuki, N., 2017 Mar 1, In : Journal of Cerebral Blood Flow and Metabolism. 37, 3, p. 890-901 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation

Someya, K., Nakatsukasa, H., Ito, M., Kondo, T., Tateda, K. I., Akanuma, T., Koya, I., Sanosaka, T., Kohyama, J., Tsukada, Y. I., Takamura-Enya, T. & Yoshimura, A., 2017 Aug 1, In : International Immunology. 29, 8, p. 365-375 11 p., dxx049.

Research output: Contribution to journalArticle

19 Citations (Scopus)

MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1

Shichita, T., Ito, M., Morita, R., Komai, K., Noguchi, Y., Ooboshi, H., Koshida, R., Takahashi, S., Kodama, T. & Yoshimura, A., 2017 Apr 10, (Accepted/In press) In : Nature Medicine.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Mechanistic insights into ectodomain shedding: Susceptibility of CADM1 adhesion molecule is determined by alternative splicing and O-glycosylation

Shirakabe, K., Omura, T., Shibagaki, Y., Mihara, E., Homma, K., Kato, Y., Yoshimura, A., Murakami, Y., Takagi, J., Hattori, S. & Ogawa, Y., 2017 Apr 10, In : Scientific Reports. 7, 46174.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjögren's syndrome

Tasaki, S., Suzuki, K., Nishikawa, A., Kassai, Y., Takiguchi, M., Kurisu, R., Okuzono, Y., Miyazaki, T., Takeshita, M., Yoshimoto, K., Yasuoka, H., Yamaoka, K., Ikeura, K., Tsunoda, K., Morita, R., Yoshimura, A., Toyoshiba, H. & Takeuchi, T., 2017 Aug 1, In : Annals of the Rheumatic Diseases. 76, 8, p. 1458-1466 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling

Queval, C. J., Song, O. R., Carralot, J. P., Saliou, J. M., Bongiovanni, A., Deloison, G., Deboosère, N., Jouny, S., Iantomasi, R., Delorme, V., Debrie, A. S., Park, S. J., Gouveia, J. C., Tomavo, S., Brosch, R., Yoshimura, A., Yeramian, E. & Brodin, P., 2017 Sep 26, In : Cell Reports. 20, 13, p. 3188-3198 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy

Kondo, T., Morita, R., Okuzono, Y., Nakatsukasa, H., Sekiya, T., Chikuma, S., Shichita, T., Kanamori, M., Kubo, M., Koga, K., Miyazaki, T., Kassai, Y. & Yoshimura, A., 2017 May 22, In : Nature Communications. 8, 15338.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Role of scavenger receptors as damage-associated molecular pattern receptors in Toll-like receptor activation

Komai, K., Shichita, T., Ito, M., Kanamori, M., Chikuma, S. & Yoshimura, A., 2017, In : International Immunology. 29, 2, p. 59-70 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

SOCS1 is a key molecule that prevents regulatory T cell plasticity under inflammatory conditions

Takahashi, R., Nakatsukasa, H., Shiozawa, S. & Yoshimura, A., 2017 Jul 1, In : Journal of Immunology. 199, 1, p. 149-158 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Stabilization of Foxp3 expression by CRISPR-dCas9-based epigenome editing in mouse primary T cells

Okada, M., Kanamori, M., Someya, K., Nakatsukasa, H. & Yoshimura, A., 2017 May 8, In : Epigenetics and Chromatin. 10, 1, 24.

Research output: Contribution to journalArticle

36 Citations (Scopus)

STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization

Kitai, Y., Iwakami, M., Saitoh, K., Togi, S., Isayama, S., Sekine, Y., Muromoto, R., Kashiwakura, J. I., Yoshimura, A., Oritani, K. & Matsuda, T., 2017 Jan 1, In : Journal of Biological Chemistry. 292, 47, p. 19392-19399 8 p.

Research output: Contribution to journalArticle

STAT3 defciency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury

Abe, M., Yoshida, T., Akiba, J., Ikezono, Y., Wada, F., Masuda, A., Sakaue, T., Tanaka, T., Iwamoto, H., Nakamura, T., Sata, M., Koga, H., Yoshimura, A. & Torimura, T., 2017 Oct 7, In : World Journal of Gastroenterology. 23, 37, p. 6833-6844 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Suppressor of cytokine signaling 3 in macrophages prevents exacerbated Interleukin-6-Dependent Arginase-1 activity and early permissiveness to experimental tuberculosis

Schmok, E., Dar, M. A., Behrends, J., Erdmann, H., Rückerl, D., Endermann, T., Heitmann, L., Hessmann, M., Yoshimura, A., Rose-John, S., Scheller, J., Schaible, U. E., Ehlers, S., Lang, R. & Hölscher, C., 2017 Nov 10, In : Frontiers in Immunology. 8, NOV, 1537.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2016

Adiponectin Enhances Antibacterial Activity of Hematopoietic Cells by Suppressing Bone Marrow Inflammation

Masamoto, Y., Arai, S., Sato, T., Yoshimi, A., Kubota, N., Takamoto, I., Iwakura, Y., Yoshimura, A., Kadowaki, T. & Kurokawa, M., 2016 Jun 21, In : Immunity. 44, 6, p. 1422-1433 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Critical Link Between Epigenetics and Transcription Factors in the Induction of Autoimmunity: a Comprehensive Review

Wu, H., Zhao, M., Yoshimura, A., Chang, C. & Lu, Q., 2016 Mar 11, (Accepted/In press) In : Clinical Reviews in Allergy and Immunology. p. 1-12 12 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Enhanced IgG4 production by follicular helper 2 T cells and the involvement of follicular helper 1 T cells in the pathogenesis of IgG4-related disease

Akiyama, M., Yasuoka, H., Yamaoka, K., Suzuki, K., Kaneko, Y., Kondo, H., Kassai, Y., Koga, K., Miyazaki, T., Morita, R., Yoshimura, A. & Takeuchi, T., 2016 Jul 13, In : Arthritis Research and Therapy. 18, 1, 167.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Erratum: Distinct effects of endogenous interleukin-23 on eosinophilic airway inflammation in response to different antigens (Allergology International (2015) 64 (S24-S29))

Ogawa, R., Suzuki, Y., Kagawa, S., Masaki, K., Fukunaga, K., Yoshimura, A., Fujishima, S., Terashima, T., Betsuyaku, T. & Asano, K., 2016 Jan 1, In : Allergology International. 65, 1, p. 120 1 p.

Research output: Contribution to journalArticle

High salt promotes autoimmunity by TET2-induced DNA demethylation and driving the differentiation of Tfh cells

Wu, H., Huang, X., Qiu, H., Zhao, M., Liao, W., Yuan, S., Xie, Y., Dai, Y., Chang, C., Yoshimura, A. & Lu, Q., 2016 Jun 21, In : Scientific Reports. 6, 28065.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Identification of definitive serum biomarkers associated with disease activity in primary Sjögren's syndrome

Nishikawa, A., Suzuki, K., Kassai, Y., Gotou, Y., Takiguchi, M., Miyazaki, T., Yoshimoto, K., Yasuoka, H., Yamaoka, K., Morita, R., Yoshimura, A. & Takeuchi, T., 2016 May 14, In : Arthritis Research and Therapy. 18, 1, 106.

Research output: Contribution to journalArticle

19 Citations (Scopus)

IL-23 Is essential for the development of Elastase-induced pulmonary inflammation and emphysema

Fujii, U., Miyahara, N., Taniguchi, A., Waseda, K., Morichika, D., Kurimoto, E., Koga, H., Kataoka, M., Gelfand, E. W., Cua, D. J., Yoshimura, A., Tanimoto, M. & Kanehiro, A., 2016 Nov 1, In : American Journal of Respiratory Cell and Molecular Biology. 55, 5, p. 697-707 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Inflammation in central nervous system diseases

Shichita, T. & Yoshimura, A., 2016 Feb 1, In : Clinical and Experimental Neuroimmunology. 7, 1, p. 18-27 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Innate-like function of memory Th17 cells for enhancing endotoxin-induced acute lung inflammation through IL-22

Sakaguchi, R., Chikuma, S., Shichita, T., Morita, R., Sekiya, T., Ouyang, W., Ueda, T., Seki, H., Morisaki, H. & Yoshimura, A., 2016 May 1, In : International Immunology. 28, 5, p. 233-243 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Interaction between a domain of the negative regulator of the ras-ERK pathway, SPRED1 protein, and the GTPase-activating protein-related domain of neurofibromin is implicated in legius syndrome and neurofibromatosis type 1

Hirata, Y., Brems, H., Suzuki, M., Kanamori, M., Okada, M., Morita, R., Llano-Rivas, I., Ose, T., Messiaen, L., Legius, E. & Yoshimura, A., 2016 Feb 12, In : Journal of Biological Chemistry. 291, 7, p. 3124-3134 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Roles of transcription factors and epigenetic modifications in differentiation and maintenance of regulatory T cells

Sekiya, T., Nakatsukasa, H., Lu, Q. & Yoshimura, A., 2016 Feb 15, (Accepted/In press) In : Microbes and Infection.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Serum proteomic analysis identifies interleukin 16 as a biomarker for clinical response during early treatment of rheumatoid arthritis

Murota, A., Suzuki, K., Kassai, Y., Miyazaki, T., Morita, R., Kondo, Y., Takeshita, M., Niki, Y., Yoshimura, A. & Takeuchi, T., 2016 Feb 1, In : Cytokine. 78, p. 87-93 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)