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Research Output 1982 2019

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2019
15 Citations (Scopus)

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Cho, H., Taniki, N., Yamaguchi, A., Kanamori, M., Kamada, N., Hattori, M., Ashida, H., Sakamoto, M., Atarashi, K., Narushima, S., Yoshimura, A., Honda, K. & 2 others, Sato, T. & Kanai, T., 2019 Jan 1, (Accepted/In press) In : Nature Microbiology.

Research output: Contribution to journalArticle

Th17 Cells
Sclerosing Cholangitis
Liver Diseases
Microbiota
Bacterial Translocation
2 Citations (Scopus)

Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression

Nakatsukasa, H., Oda, M., Yin, J., Chikuma, S., Ito, M., Koga-Iizuka, M., Someya, K., Kitagawa, Y., Ohkura, N., Sakaguchi, S., Koya, I., Sanosaka, T., Kohyama, J., Tsukada, Y. I., Yamanaka, S., Takamura-Enya, T., Lu, Q. & Yoshimura, A., 2019 Jan 1, In : International immunology. 31, 5, p. 335-347 13 p.

Research output: Contribution to journalArticle

Interleukin-17
Protein Transport
Regulatory T-Lymphocytes
Immunoglobulin G
5-Methylcytosine
1 Citation (Scopus)

mir-181A/B-1 controls thymic selection of treg cells and tunes their suppressive capacity

Łyszkiewicz, M., Winter, S. J., Witzlau, K., Föhse, L., Brownlie, R., Puchałka, J., Verheyden, N. A., Kunze-Schumacher, H., Imelmann, E., Blume, J., Raha, S., Sekiya, T., Yoshimura, A., Frueh, J. T., Ullrich, E., Huehn, J., Weiss, S., Gutierrez, M. G., Prinz, I., Zamoyska, R. & 2 others, Ziętara, N. & Krueger, A., 2019 Mar 1, In : PLoS Biology. 17, 3, e2006716.

Research output: Contribution to journalArticle

Open Access
Thymus
T-cells
Regulatory T-Lymphocytes
T-Cell Antigen Receptor
MicroRNAs

Multi-dimensional analysis identified rheumatoid arthritis-driving pathway in human T cell

Takeshita, M., Suzuki, K., Kondo, Y., Morita, R., Okuzono, Y., Koga, K., Kassai, Y., Gamo, K., Takiguchi, M., Kurisu, R., Mototani, H., Ebisuno, Y., Yoshimura, A. & Takeuchi, T., 2019 Jan 1, In : Annals of the rheumatic diseases.

Research output: Contribution to journalArticle

T-cells
Rheumatoid Arthritis
T-Lymphocytes
Genes
Synovial Fluid
2 Citations (Scopus)

Significant association between joint ultrasonographic parameters and synovial inflammatory factors in rheumatoid arthritis

Kondo, Y., Suzuki, K., Inoue, Y., Sakata, K., Takahashi, C., Takeshita, M., Kassai, Y., Miyazaki, T., Morita, R., Niki, Y., Kaneko, Y., Yasuoka, H., Yamaoka, K., Yoshimura, A. & Takeuchi, T., 2019 Oct 1, In : Arthritis Research and Therapy. 21, 1, 14.

Research output: Contribution to journalArticle

Ultrasonography
Rheumatoid Arthritis
Joints
Synovitis
Synovial Membrane

Tissue regulatory T cells and neural repair

Ito, M., Komai, K., Nakamura, T., Srirat, T. & Yoshimura, A., 2019 May 21, In : International immunology. 31, 6, p. 361-369 9 p.

Research output: Contribution to journalArticle

Open Access
Regulatory T-Lymphocytes
Brain
Serotonin
Inflammation
Serotonin Receptors
2018
3 Citations (Scopus)

Generation and application of human induced-stem cell memory T cells for adoptive immunotherapy

Kondo, T., Imura, Y., Chikuma, S., Hibino, S., Omata-Mise, S., Ando, M., Akanuma, T., Iizuka, M., Sakai, R., Morita, R. & Yoshimura, A., 2018 Jul 1, In : Cancer Science. 109, 7, p. 2130-2140 11 p.

Research output: Contribution to journalArticle

Adoptive Immunotherapy
Stem Cells
T-Lymphocytes
Cell- and Tissue-Based Therapy
Immunotherapy
1 Citation (Scopus)

IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse

Oike, T., Kanagawa, H., Sato, Y., Kobayashi, T., Nakatsukasa, H., Miyamoto, K., Nakamura, S., Kaneko, Y., Kobayashi, S., Harato, K., Yoshimura, A., Iwakura, Y., Takeuchi, T., Matsumoto, M., Nakamura, M., Niki, Y. & Miyamoto, T., 2018 Dec 1, In : Scientific Reports. 8, 1, 15783.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Interleukin-17
Interleukin-6
Joints
Inflammation
5 Citations (Scopus)

Inhibition of Nr4a receptors enhances antitumor immunity by breaking treg-mediated immune tolerance

Hibino, S., Chikuma, S., Kondo, T., Ito, M., Nakatsukasa, H., Omata-Mise, S. & Yoshimura, A., 2018 Jun 1, In : Cancer Research. 78, 11, p. 3027-3040 14 p.

Research output: Contribution to journalArticle

Immune Tolerance
Immunity
Neoplasms
Tumor Microenvironment
Immunosuppressive Agents
9 Citations (Scopus)

Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission

Tasaki, S., Suzuki, K., Kassai, Y., Takeshita, M., Murota, A., Kondo, Y., Ando, T., Nakayama, Y., Okuzono, Y., Takiguchi, M., Kurisu, R., Miyazaki, T., Yoshimoto, K., Yasuoka, H., Yamaoka, K., Morita, R., Yoshimura, A., Toyoshiba, H. & Takeuchi, T., 2018 Dec 1, In : Nature Communications. 9, 1, 2755.

Research output: Contribution to journalArticle

Drug therapy
arthritis
Drug Monitoring
Rheumatoid Arthritis
drugs
13 Citations (Scopus)
Immunity
Suppressor of Cytokine Signaling Proteins
T-cells
Cytokines
Janus Kinases
1 Citation (Scopus)

NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation

Kimura, A., Kitajima, M., Nishida, K., Serada, S., Fujimoto, M., Naka, T., Fujii-Kuriyama, Y., Sakamato, S., Ito, T., Handa, H., Tanaka, T., Yoshimura, A. & Suzuki, H., 2018 Sep 1, In : Journal of Experimental Medicine. 215, 8, p. 2197-2209 13 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Cytokines
Interleukin-6
Macrophages
Quinones

Nr4a Receptors Regulate Development and Death of Labile Treg Precursors to Prevent Generation of Pathogenic Self-Reactive Cells

Sekiya, T., Hibino, S., Saeki, K., Kanamori, M., Takaki, S. & Yoshimura, A., 2018 Aug 7, In : Cell Reports. 24, 6, p. 1627-1638.e6

Research output: Contribution to journalArticle

Cell death
Regulatory T-Lymphocytes
Cytoplasmic and Nuclear Receptors
Thymocytes
Cell Death
4 Citations (Scopus)

Pivotal role of innate myeloid cells in cerebral post-ischemic sterile inflammation

Tsuyama, J., Nakamura, A., Ooboshi, H., Yoshimura, A. & Shichita, T., 2018 Jan 1, (Accepted/In press) In : Seminars in Immunopathology.

Research output: Contribution to journalArticle

Myeloid Cells
Stroke
Inflammation
Brain
Microglia

Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection

Fujiwara, S., Hoshizaki, M., Ichida, Y., Lex, D., Kuroda, E., Ishii, K. J., Magi, S., Okada, M., Takao, H., Gandou, M., Imai, H., Hara, R., Herzog, H., Yoshimura, A., Okamura, H., Penninger, J. M., Slutsky, A. S., Uhlig, S., Kuba, K. & Imai, Y., 2018 Jan 1, (Accepted/In press) In : Nature Microbiology.

Research output: Contribution to journalArticle

Neuropeptide Y
Virus Diseases
Phagocytes
Orthomyxoviridae
Pathology
4 Citations (Scopus)

Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3

Tanaka, K., Martinez, G. J., Yan, X., Long, W., Ichiyama, K., Chi, X., Kim, B. S., Reynolds, J. M., Chung, Y., Tanaka, S., Liao, L., Nakanishi, Y., Yoshimura, A., Zheng, P., Wang, X., Tian, Q., Xu, J., O'Malley, B. W. & Dong, C., 2018 May 22, In : Cell Reports. 23, 8, p. 2318-2329 12 p.

Research output: Contribution to journalArticle

Nuclear Receptor Coactivator 3
Th17 Cells
Cell Differentiation
Interleukin-1
Interleukin-6
2 Citations (Scopus)

Reprogramming of Th1 cells into regulatory T cells through rewiring of the metabolic status

Kanamori, M., Nakatsukasa, H., Ito, M., Chikuma, S. & Yoshimura, A., 2018 Jan 1, In : International Immunology. 30, 8, p. 357-373 17 p.

Research output: Contribution to journalArticle

Th1 Cells
Regulatory T-Lymphocytes
Transforming Growth Factor beta
T-Lymphocyte Subsets
T-Cell Antigen Receptor
4 Citations (Scopus)

Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress

Tadokoro, Y., Hoshii, T., Yamazaki, S., Eto, K., Ema, H., Kobayashi, M., Ueno, M., Ohta, K., Arai, Y., Hara, E., Harada, K., Oshima, M., Oshima, H., Arai, F., Yoshimura, A., Nakauchi, H. & Hirao, A., 2018 May 3, In : Cell Stem Cell. 22, 5, p. 713-725.e8

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Homeostasis
Diet
High Fat Diet
Dysbiosis
6 Citations (Scopus)

STAT3 expression by myeloid cells is detrimental for the T- cell-mediated control of infection with Mycobacterium tuberculosis

Gao, Y., Basile, J. I., Classon, C., Gavier-Widen, D., Yoshimura, A., Carow, B. & Rottenberg, M. E., 2018 Jan 1, In : PLoS Pathogens. 14, 1, e1006809.

Research output: Contribution to journalArticle

Interleukin-17
Myeloid Cells
Infection Control
Mycobacterium tuberculosis
T-Lymphocytes
2017
8 Citations (Scopus)

A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium

Eritja, N., Felip, I., Dosil, M. A., Vigezzi, L., Mirantes, C., Yeramian, A., Navaridas, R., Santacana, M., Llobet-Navas, D., Yoshimura, A., Nomura, M., Encinas, M., Matias-Guiu, X. & Dolcet, X., 2017 Aug 1, In : Cell Death and Differentiation. 24, 8, p. 1443-1458 16 p.

Research output: Contribution to journalArticle

Endometrium
Phosphatidylinositol 3-Kinases
Apoptosis
Cell Proliferation
Carcinogens
15 Citations (Scopus)

Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells

Okada, M., Chikuma, S., Kondo, T., Hibino, S., Machiyama, H., Yokosuka, T., Nakano, M. & Yoshimura, A., 2017 Aug 1, In : Cell Reports. 20, 5, p. 1017-1028 12 p.

Research output: Contribution to journalArticle

T-cells
Cell death
Tumors
Cell Death
T-Lymphocytes
12 Citations (Scopus)

Brain Micro-Inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit

Arima, Y., Ohki, T., Nishikawa, N., Higuchi, K., Ota, M., Tanaka, Y., Nio-Kobayashi, J., Elfeky, M., Sakai, R., Mori, Y., Kawamoto, T., Stofkova, A., Sakashita, Y., Morimoto, Y., Kuwatani, M., Iwanaga, T., Yoshioka, Y., Sakamoto, N., Yoshimura, A., Takiguchi, M. & 4 others, Sakoda, S., Prinz, M., Kamimura, D. & Murakami, M., 2017 Aug 15, In : eLife. 6, e25517.

Research output: Contribution to journalArticle

Encephalitis
Neural Pathways
Brain
Homeostasis
Chemical activation

CISH controls bacterial burden early after infection with Mycobacterium tuberculosis in mice

Carow, B., Gao, Y., Terán, G., Yang, X. O., Dong, C., Yoshimura, A. & Rottenberg, M. E., 2017 Dec 1, In : Tuberculosis. 107, p. 175-180 6 p.

Research output: Contribution to journalArticle

Mycobacterium tuberculosis
Infection
Mycobacterium Infections
Lung
Messenger RNA
4 Citations (Scopus)

E3 ubiquitin ligases SIAH1/2 regulate hypoxiainducible factor-1 (HIF-1)-mediated Th17 cell differentiation

Matsui-Hasumi, A., Sato, Y., Uto-Konomi, A., Yamashita, S., Uehori, J., Yoshimura, A., Yamashita, M., Asahara, H., Suzuki, S. & Kubo, M., 2017 Mar 1, In : International Immunology. 29, 3, p. 133-143 11 p., dxx014.

Research output: Contribution to journalArticle

Th17 Cells
Ubiquitin-Protein Ligases
Cell Differentiation
Interleukin-17
Ligases
8 Citations (Scopus)

Generation of allo-antigen-specific induced Treg stabilized by vitamin C treatment and its application for prevention of acute graft versus host disease model

Kasahara, H., Kondo, T., Nakatsukasa, H., Chikuma, S., Ito, M., Ando, M., Kurebayashi, Y., Sekiya, T., Yamada, T., Okamoto, S. & Yoshimura, A., 2017 Oct 1, In : International Immunology. 29, 10, p. 457-469 13 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Ascorbic Acid
Antigens
Transplants
T-Lymphocytes
12 Citations (Scopus)

High-mobility group box 1 is an important mediator of microglial activation induced by cortical spreading depression

Takizawa, T., Shibata, M., Kayama, Y., Shimizu, T., Toriumi, H., Ebine, T., Unekawa, M., Koh, A., Yoshimura, A. & Suzuki, N., 2017 Mar 1, In : Journal of Cerebral Blood Flow and Metabolism. 37, 3, p. 890-901 12 p.

Research output: Contribution to journalArticle

Cortical Spreading Depression
Microglia
Hypertrophy
Glycyrrhizic Acid
Toll-Like Receptor 2
13 Citations (Scopus)

Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation

Someya, K., Nakatsukasa, H., Ito, M., Kondo, T., Tateda, K. I., Akanuma, T., Koya, I., Sanosaka, T., Kohyama, J., Tsukada, Y. I., Takamura-Enya, T. & Yoshimura, A., 2017 Aug 1, In : International Immunology. 29, 8, p. 365-375 11 p., dxx049.

Research output: Contribution to journalArticle

Enzyme Induction
Enzyme Activation
Catalytic Domain
5-Methylcytosine
Oxygen
35 Citations (Scopus)

MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1

Shichita, T., Ito, M., Morita, R., Komai, K., Noguchi, Y., Ooboshi, H., Koshida, R., Takahashi, S., Kodama, T. & Yoshimura, A., 2017 Apr 10, (Accepted/In press) In : Nature Medicine.

Research output: Contribution to journalArticle

MafB Transcription Factor
Class A Scavenger Receptors
Stroke
Tissue
Inflammation
5 Citations (Scopus)

Mechanistic insights into ectodomain shedding: Susceptibility of CADM1 adhesion molecule is determined by alternative splicing and O-glycosylation

Shirakabe, K., Omura, T., Shibagaki, Y., Mihara, E., Homma, K., Kato, Y., Yoshimura, A., Murakami, Y., Takagi, J., Hattori, S. & Ogawa, Y., 2017 Apr 10, In : Scientific Reports. 7, 46174.

Research output: Contribution to journalArticle

Alternative Splicing
Cell Adhesion Molecules
Glycosylation
Membrane Proteins
Metalloproteases
14 Citations (Scopus)

Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjögren's syndrome

Tasaki, S., Suzuki, K., Nishikawa, A., Kassai, Y., Takiguchi, M., Kurisu, R., Okuzono, Y., Miyazaki, T., Takeshita, M., Yoshimoto, K., Yasuoka, H., Yamaoka, K., Ikeura, K., Tsunoda, K., Morita, R., Yoshimura, A., Toyoshiba, H. & Takeuchi, T., 2017 Aug 1, In : Annals of the Rheumatic Diseases. 76, 8, p. 1458-1466 9 p.

Research output: Contribution to journalArticle

T-cells
Genes
T-Lymphocytes
Pathology
Immunophenotyping
15 Citations (Scopus)

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling

Queval, C. J., Song, O. R., Carralot, J. P., Saliou, J. M., Bongiovanni, A., Deloison, G., Deboosère, N., Jouny, S., Iantomasi, R., Delorme, V., Debrie, A. S., Park, S. J., Gouveia, J. C., Tomavo, S., Brosch, R., Yoshimura, A., Yeramian, E. & Brodin, P., 2017 Sep 26, In : Cell Reports. 20, 13, p. 3188-3198 11 p.

Research output: Contribution to journalArticle

Acidification
Mycobacterium tuberculosis
Adenosine Triphosphatases
Macrophages
Pathogens
21 Citations (Scopus)

Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy

Kondo, T., Morita, R., Okuzono, Y., Nakatsukasa, H., Sekiya, T., Chikuma, S., Shichita, T., Kanamori, M., Kubo, M., Koga, K., Miyazaki, T., Kassai, Y. & Yoshimura, A., 2017 May 22, In : Nature Communications. 8, 15338.

Research output: Contribution to journalArticle

Adoptive Immunotherapy
T-cells
stem cells
notches
Stem cells
8 Citations (Scopus)

Role of scavenger receptors as damage-associated molecular pattern receptors in Toll-like receptor activation

Komai, K., Shichita, T., Ito, M., Kanamori, M., Chikuma, S. & Yoshimura, A., 2017, In : International Immunology. 29, 2, p. 59-70 12 p.

Research output: Contribution to journalArticle

Scavenger Receptors
Toll-Like Receptors
Class A Scavenger Receptors
Macrophages
Cytokines
11 Citations (Scopus)

SOCS1 is a key molecule that prevents regulatory T cell plasticity under inflammatory conditions

Takahashi, R., Nakatsukasa, H., Shiozawa, S. & Yoshimura, A., 2017 Jul 1, In : Journal of Immunology. 199, 1, p. 149-158 10 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Cell Plasticity
Th17 Cells
Tumor Microenvironment
Splenomegaly
30 Citations (Scopus)

Stabilization of Foxp3 expression by CRISPR-dCas9-based epigenome editing in mouse primary T cells

Okada, M., Kanamori, M., Someya, K., Nakatsukasa, H. & Yoshimura, A., 2017 May 8, In : Epigenetics and Chromatin. 10, 1, 24.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Epigenomics
T-Lymphocytes
Dioxygenases
Gene Expression

STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization

Kitai, Y., Iwakami, M., Saitoh, K., Togi, S., Isayama, S., Sekine, Y., Muromoto, R., Kashiwakura, J. I., Yoshimura, A., Oritani, K. & Matsuda, T., 2017 Jan 1, In : Journal of Biological Chemistry. 292, 47, p. 19392-19399 8 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Prostatic Neoplasms
Stabilization
Cells
Growth
6 Citations (Scopus)

STAT3 defciency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury

Abe, M., Yoshida, T., Akiba, J., Ikezono, Y., Wada, F., Masuda, A., Sakaue, T., Tanaka, T., Iwamoto, H., Nakamura, T., Sata, M., Koga, H., Yoshimura, A. & Torimura, T., 2017 Oct 7, In : World Journal of Gastroenterology. 23, 37, p. 6833-6844 12 p.

Research output: Contribution to journalArticle

Thioacetamide
Liver
Wounds and Injuries
Hepatocytes
Hepatocellular Carcinoma
3 Citations (Scopus)

Suppressor of cytokine signaling 3 in macrophages prevents exacerbated Interleukin-6-Dependent Arginase-1 activity and early permissiveness to experimental tuberculosis

Schmok, E., Dar, M. A., Behrends, J., Erdmann, H., Rückerl, D., Endermann, T., Heitmann, L., Hessmann, M., Yoshimura, A., Rose-John, S., Scheller, J., Schaible, U. E., Ehlers, S., Lang, R. & Hölscher, C., 2017 Nov 10, In : Frontiers in Immunology. 8, NOV, 1537.

Research output: Contribution to journalArticle

Permissiveness
Arginase
Interleukin-6
Tuberculosis
Macrophages
2016
12 Citations (Scopus)

Adiponectin Enhances Antibacterial Activity of Hematopoietic Cells by Suppressing Bone Marrow Inflammation

Masamoto, Y., Arai, S., Sato, T., Yoshimi, A., Kubota, N., Takamoto, I., Iwakura, Y., Yoshimura, A., Kadowaki, T. & Kurokawa, M., 2016 Jun 21, In : Immunity. 44, 6, p. 1422-1433 12 p.

Research output: Contribution to journalArticle

Osteitis
Adiponectin
Obesity
Hematopoietic Stem Cells
Bone Marrow
30 Citations (Scopus)

Critical Link Between Epigenetics and Transcription Factors in the Induction of Autoimmunity: a Comprehensive Review

Wu, H., Zhao, M., Yoshimura, A., Chang, C. & Lu, Q., 2016 Mar 11, (Accepted/In press) In : Clinical Reviews in Allergy and Immunology. p. 1-12 12 p.

Research output: Contribution to journalArticle

Autoimmunity
Epigenomics
Transcription Factors
Autoimmune Diseases
Systemic Lupus Erythematosus
59 Citations (Scopus)

Enhanced IgG4 production by follicular helper 2 T cells and the involvement of follicular helper 1 T cells in the pathogenesis of IgG4-related disease

Akiyama, M., Yasuoka, H., Yamaoka, K., Suzuki, K., Kaneko, Y., Kondo, H., Kassai, Y., Koga, K., Miyazaki, T., Morita, R., Yoshimura, A. & Takeuchi, T., 2016 Jul 13, In : Arthritis Research and Therapy. 18, 1, 167.

Research output: Contribution to journalArticle

Th2 Cells
Th1 Cells
Immunoglobulin G
B-Lymphocytes
T-Lymphocyte Subsets

Erratum: Distinct effects of endogenous interleukin-23 on eosinophilic airway inflammation in response to different antigens (Allergology International (2015) 64 (S24-S29))

Ogawa, R., Suzuki, Y., Kagawa, S., Masaki, K., Fukunaga, K., Yoshimura, A., Fujishima, S., Terashima, T., Betsuyaku, T. & Asano, K., 2016 Jan 1, In : Allergology International. 65, 1, p. 120 1 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

High salt promotes autoimmunity by TET2-induced DNA demethylation and driving the differentiation of Tfh cells

Wu, H., Huang, X., Qiu, H., Zhao, M., Liao, W., Yuan, S., Xie, Y., Dai, Y., Chang, C., Yoshimura, A. & Lu, Q., 2016 Jun 21, In : Scientific Reports. 6, 28065.

Research output: Contribution to journalArticle

Autoimmunity
Cell Differentiation
Salts
DNA
Inbred MRL lpr Mouse
17 Citations (Scopus)

Identification of definitive serum biomarkers associated with disease activity in primary Sjögren's syndrome

Nishikawa, A., Suzuki, K., Kassai, Y., Gotou, Y., Takiguchi, M., Miyazaki, T., Yoshimoto, K., Yasuoka, H., Yamaoka, K., Morita, R., Yoshimura, A. & Takeuchi, T., 2016 May 14, In : Arthritis Research and Therapy. 18, 1, 106.

Research output: Contribution to journalArticle

Biomarkers
Serum
Receptors, Tumor Necrosis Factor, Type II
Proteins
Enzyme-Linked Immunosorbent Assay
11 Citations (Scopus)

IL-23 Is essential for the development of Elastase-induced pulmonary inflammation and emphysema

Fujii, U., Miyahara, N., Taniguchi, A., Waseda, K., Morichika, D., Kurimoto, E., Koga, H., Kataoka, M., Gelfand, E. W., Cua, D. J., Yoshimura, A., Tanimoto, M. & Kanehiro, A., 2016 Nov 1, In : American Journal of Respiratory Cell and Molecular Biology. 55, 5, p. 697-707 11 p.

Research output: Contribution to journalArticle

Interleukin-23
Pulmonary Emphysema
Pancreatic Elastase
Pneumonia
Swine
2 Citations (Scopus)

Inflammation in central nervous system diseases

Shichita, T. & Yoshimura, A., 2016 Feb 1, In : Clinical and Experimental Neuroimmunology. 7, 1, p. 18-27 10 p.

Research output: Contribution to journalArticle

Central Nervous System Diseases
Inflammation
Pattern Recognition Receptors
Nervous System Diseases
Neuroglia
9 Citations (Scopus)

Innate-like function of memory Th17 cells for enhancing endotoxin-induced acute lung inflammation through IL-22

Sakaguchi, R., Chikuma, S., Shichita, T., Morita, R., Sekiya, T., Ouyang, W., Ueda, T., Seki, H., Morisaki, H. & Yoshimura, A., 2016 May 1, In : International Immunology. 28, 5, p. 233-243 11 p.

Research output: Contribution to journalArticle

Interleukin-23
Th17 Cells
Endotoxins
Pneumonia
Acute Lung Injury
20 Citations (Scopus)

Interaction between a domain of the negative regulator of the ras-ERK pathway, SPRED1 protein, and the GTPase-activating protein-related domain of neurofibromin is implicated in legius syndrome and neurofibromatosis type 1

Hirata, Y., Brems, H., Suzuki, M., Kanamori, M., Okada, M., Morita, R., Llano-Rivas, I., Ose, T., Messiaen, L., Legius, E. & Yoshimura, A., 2016 Feb 12, In : Journal of Biological Chemistry. 291, 7, p. 3124-3134 11 p.

Research output: Contribution to journalArticle

Neurofibromin 1
GTPase-Activating Proteins
Neurofibromatosis 1
MAP Kinase Signaling System
Proteins
11 Citations (Scopus)

Roles of transcription factors and epigenetic modifications in differentiation and maintenance of regulatory T cells

Sekiya, T., Nakatsukasa, H., Lu, Q. & Yoshimura, A., 2016 Feb 15, (Accepted/In press) In : Microbes and Infection.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Epigenomics
Transcription Factors
Maintenance
Gene Silencing
16 Citations (Scopus)

Serum proteomic analysis identifies interleukin 16 as a biomarker for clinical response during early treatment of rheumatoid arthritis

Murota, A., Suzuki, K., Kassai, Y., Miyazaki, T., Morita, R., Kondo, Y., Takeshita, M., Niki, Y., Yoshimura, A. & Takeuchi, T., 2016 Feb 1, In : Cytokine. 78, p. 87-93 7 p.

Research output: Contribution to journalArticle

Interleukin-16
Biomarkers
Methotrexate
Proteomics
Matrix Metalloproteinase 3