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Fingerprint Dive into the research topics where Daisuke Aki is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles
Ubiquitin-Protein Ligases Medicine & Life Sciences
Cytokines Medicine & Life Sciences
Toll-Like Receptors Medicine & Life Sciences
Ubiquitination Medicine & Life Sciences
Lipopolysaccharides Medicine & Life Sciences
Proteins Medicine & Life Sciences
Macrophages Medicine & Life Sciences
Centrosome Medicine & Life Sciences

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Research Output 2002 2019

  • 2185 Citations
  • 18 h-Index
  • 24 Article
  • 1 Chapter
  • 1 Review article

Immune regulation by protein ubiquitination: roles of the E3 ligases VHL and Itch

Aki, D., Li, Q., Li, H., Liu, Y. C. & Lee, J. H., 2019 Jun 1, In : Protein and Cell. 10, 6, p. 395-404 10 p.

Research output: Contribution to journalReview article

Open Access
Ubiquitin-Protein Ligases
Ubiquitination
T-cells
Ubiquitin
Proteins

The E3 ligase VHL promotes follicular helper T cell differentiation via glycolytic-epigenetic control

Zhu, Y., Zhao, Y., Zou, L., Zhang, D., Aki, D. & Liu, Y. C., 2019 Jul 1, In : The Journal of experimental medicine. 216, 7, p. 1664-1681 18 p.

Research output: Contribution to journalArticle

Open Access
Ubiquitin-Protein Ligases
Helper-Inducer T-Lymphocytes
Epigenomics
Hypoxia-Inducible Factor 1
Cell Differentiation
7 Citations (Scopus)

The E3 ligases Itch and WWP2 cooperate to limit T H 2 differentiation by enhancing signaling through the TCR

Aki, D., Li, H., Zhang, W., Zheng, M., Elly, C., Lee, J. H., Zou, W. & Liu, Y. C., 2018 Jul 1, In : Nature Immunology. 19, 7, p. 766-775 10 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
T-Cell Antigen Receptor
T-Lymphocytes
Non-Receptor Type 6 Protein Tyrosine Phosphatase
Th2 Cells

The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation

Zhang, W., Li, Q., Li, D., Li, J., Aki, D. & Liu, Y. C., 2018 Dec 1, In : Journal of Experimental Medicine. 215, 12, p. 3180-3193 14 p.

Research output: Contribution to journalArticle

Open Access
Ubiquitin-Protein Ligases
Alveolar Macrophages
Glycolysis
Epigenomics
Osteopontin
22 Citations (Scopus)

The E3 ligase Itch in immune regulation and beyond

Aki, D., Zhang, W. & Liu, Y. C., 2015 Jul 1, In : Immunological Reviews. 266, 1, p. 6-26 21 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Ubiquitination
Protein C
Proteins
Ubiquitin