• 2318 Citations
  • 18 h-Index
20022019

Research output per year

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Research Output

  • 2318 Citations
  • 18 h-Index
  • 21 Article
  • 3 Review article
  • 1 Chapter
  • 1 Comment/debate
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Article
2019

The E3 ligase VHL promotes follicular helper T cell differentiation via glycolytic-epigenetic control

Zhu, Y., Zhao, Y., Zou, L., Zhang, D., Aki, D. & Liu, Y. C., 2019, In : Journal of Experimental Medicine. 216, 7, p. 1664-1681 18 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)
2018

The E3 ligases Itch and WWP2 cooperate to limit T H 2 differentiation by enhancing signaling through the TCR

Aki, D., Li, H., Zhang, W., Zheng, M., Elly, C., Lee, J. H., Zou, W. & Liu, Y. C., 2018 Jul 1, In : Nature Immunology. 19, 7, p. 766-775 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation

Zhang, W., Li, Q., Li, D., Li, J., Aki, D. & Liu, Y. C., 2018 Dec 1, In : Journal of Experimental Medicine. 215, 12, p. 3180-3193 14 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)
2015

The E3 ligase Itch in immune regulation and beyond

Aki, D., Zhang, W. & Liu, Y. C., 2015 Jul 1, In : Immunological Reviews. 266, 1, p. 6-26 21 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2013

Haploinsufficiency of SAMD9L, an Endosome Fusion Facilitator, Causes Myeloid Malignancies in Mice Mimicking Human Diseases with Monosomy 7

Nagamachi, A., Matsui, H., Asou, H., Ozaki, Y., Aki, D., Kanai, A., Takubo, K., Suda, T., Nakamura, T., Wolff, L., Honda, H. & Inaba, T., 2013 Sep 9, In : Cancer Cell. 24, 3, p. 305-317 13 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)
2012

Poly-ADP Ribosylation of Miki by tankyrase-1 Promotes Centrosome Maturation

Ozaki, Y., Matsui, H., Asou, H., Nagamachi, A., Aki, D., Honda, H., Yasunaga, S., Takihara, Y., Yamamoto, T., Izumi, S., Ohsugi, M. & Inaba, T., 2012 Sep 14, In : Molecular Cell. 47, 5, p. 694-706 13 p.

Research output: Contribution to journalArticle

Open Access
45 Citations (Scopus)
2011

The dynactin complex maintains the integrity of metaphasic centrosomes to ensure transition to anaphase

Ozaki, Y., Matsui, H., Nagamachi, A., Asou, H., Aki, D. & Inaba, T., 2011 Feb 18, In : Journal of Biological Chemistry. 286, 7, p. 5589-5598 10 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

To go or not to go: The "itchy" effect on the destiny of hematopoietic stem cells

Aki, D. & Liu, Y. C., 2011 Aug, In : Cell Research. 21, 8, p. 1161-1163 3 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2010

Up-regulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17;19)-positive leukemia cells

Okuya, M., Kurosawa, H., Kikuchi, J., Furukawa, Y., Matsui, H., Aki, D., Matsunaga, T., Inukai, T., Goto, H., Altura, R. A., Sugita, K., Arisaka, O., Lookand, A. T. & Inaba, T., 2010 Jan 15, In : Journal of Biological Chemistry. 285, 3, p. 1850-1860 11 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)
2009

A major lipid raft protein raftlin modulates T cell receptor signaling and enhances Th17-mediated autoimmune responses

Saeki, K., Fukuyama, S., Ayada, T., Nakaya, M., Aki, D., Takaesu, G., Hanada, T., Matsumura, Y., Kobayashi, T., Nakagawa, R. & Yoshimura, A., 2009 May 15, In : Journal of Immunology. 182, 10, p. 5929-5937 9 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Identification of a common microdeletion cluster in 7q21.3 subband among patients with myeloid leukemia and myelodysplastic syndrome

Asou, H., Matsui, H., Ozaki, Y., Nagamachi, A., Nakamura, M., Aki, D. & Inaba, T., 2009 May 29, In : Biochemical and Biophysical Research Communications. 383, 2, p. 245-251 7 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
2008

Peptidoglycan and lipopolysaccharide activate PLCγ2, leading to enhanced cytokine production in macrophages and dendritic cells

Aki, D., Minoda, Y., Yoshida, H., Watanabe, S., Yoshida, R., Takaesu, G., Chinen, T., Inaba, T., Hikida, M., Kurosaki, T., Saeki, K. & Yoshimura, A., 2008 Feb, In : Genes to Cells. 13, 2, p. 199-208 10 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)
2006

A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling

Minoda, Y., Saeki, K., Aki, D., Takaki, H., Sanada, T., Koga, K., Kobayashi, T., Takaesu, G. & Yoshimura, A., 2006 Jun 9, In : Biochemical and Biophysical Research Communications. 344, 3, p. 1023-1030 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2005

FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling

Mashima, R., Saeki, K., Aki, D., Minoda, Y., Takaki, H., Sanada, T., Kobayashi, T., Aburatani, H., Yamanashi, Y. & Yoshimura, A., 2005 Dec 16, In : Journal of Biological Chemistry. 280, 50, p. 41289-41297 9 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Modulation of TLR signalling by the C-terminal Src kinase (Csk) in macrophages

Aki, D., Mashima, R., Saeki, K., Minoda, Y., Yamauchi, M. & Yoshimura, A., 2005 Apr, In : Genes to Cells. 10, 4, p. 357-368 12 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Suppressors of cytokine signaling-1 and -3 regulate osteoclastogenesis in the presence of inflammatory cytokines

Ohishi, M., Matsumura, Y., Aki, D., Mashima, R., Taniguchi, K., Kobayashi, T., Kukita, T., Iwamoto, Y. & Yoshimura, A., 2005 Mar 1, In : Journal of Immunology. 174, 5, p. 3024-3031 8 p.

Research output: Contribution to journalArticle

Open Access
31 Citations (Scopus)
2004

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

Mori, H., Hanada, R., Hanada, T., Aki, D., Mashima, R., Nishinakamura, H., Torisu, T., Chien, K. R., Yasukawa, H. & Yoshimura, A., 2004 Jul 1, In : Nature medicine. 10, 7, p. 739-743 5 p.

Research output: Contribution to journalArticle

463 Citations (Scopus)
2003

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

Yasukawa, H., Ohishi, M., Mori, H., Murakami, M., Chinen, T., Aki, D., Hanada, T., Takeda, K., Akira, S., Hoshijima, M., Hirano, T., Chien, K. R. & Yoshimura, A., 2003 Jun 1, In : Nature Immunology. 4, 6, p. 551-556 6 p.

Research output: Contribution to journalArticle

565 Citations (Scopus)

STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif

Minoguchi, M., Minoguchi, S., Aki, D., Joo, A., Yamamoto, T., Yumioka, T., Matsuda, T. & Yoshimura, A., 2003 Mar 28, In : Journal of Biological Chemistry. 278, 13, p. 11182-11189 8 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction

Saeki, K., Miura, Y., Aki, D., Kurosaki, T. & Yoshimura, A., 2003 Jun 16, In : EMBO Journal. 22, 12, p. 3015-3026 12 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)
2002

SOCS1/JAB is a negative regulator of LPS-induced macrophage activation

Kinjyo, I., Hanada, T., Inagaki-Ohara, K., Mori, H., Aki, D., Ohishi, M., Yoshida, H., Kubo, M. & Yoshimura, A., 2002 Nov 1, In : Immunity. 17, 5, p. 583-591 9 p.

Research output: Contribution to journalArticle

507 Citations (Scopus)