• 3476 Citations
  • 32 h-Index
1981 …2020

Research output per year

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Research Output

  • 3476 Citations
  • 32 h-Index
  • 156 Article
  • 4 Review article
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Article
2020

LC–MS analysis of saponins of Achyranthes root in the Japanese market

Kuwada, K., Kawase, S., Nakata, K., Shinya, N., Narukawa, Y., Fuchino, H., Kawahara, N. & Kiuchi, F., 2020 Jan 1, In : Journal of Natural Medicines. 74, 1, p. 135-141 7 p.

Research output: Contribution to journalArticle

2019

Synthesis of the Non Reducing End Oligosaccharides of Glycosphingolipids from Ascaris suum

Hada, N., Umeda, Y., Kumada, H., Shimazaki, Y., Yamano, K., Schweizer, F., Oshima, N., Takeda, T. & Kiuchi, F., 2019 Jan 1, In : Chemical and Pharmaceutical Bulletin. 67, 2, p. 143-154 12 p.

Research output: Contribution to journalArticle

2018

A novel derivative (GTN024) from a natural product, komaroviquinone, induced the apoptosis of high-risk myeloma cells via reactive oxygen production and ER stress

Okayama, M., Kitabatake, S., Sato, M., Fujimori, K., Ichikawa, D., Matsushita, M., Suto, Y., Iwasaki, G., Yamada, T., Kiuchi, F., Hirao, M., Kunieda, H., Osada, M., Okamoto, S. & Hattori, Y., 2018 Nov 2, In : Biochemical and Biophysical Research Communications. 505, 3, p. 787-793 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
1 Citation (Scopus)

Preparation of menisdaurigenin and related compounds

Shirakawa, R., Ishikawa, S., Takahasi, M., Ueno, Y., Uekusa, Y., Narukawa, Y., Sugai, T. & Kiuchi, F., 2018 Jan 1, (Accepted/In press) In : Journal of Natural Medicines.

Research output: Contribution to journalArticle

Quantitative analysis of the anti-inflammatory activity of orengedokuto II: berberine is responsible for the inhibition of NO production

Oshima, N., Shimizu, T., Narukawa, Y., Hada, N. & Kiuchi, F., 2018 Apr 18, (Accepted/In press) In : Journal of Natural Medicines. p. 1-9 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Taxodione induces apoptosis in BCR-ABL-positive cells through ROS generation

Uchihara, Y., Tago, K., Taguchi, H., Narukawa, Y., Kiuchi, F., Tamura, H. & Tago, M., 2018 Aug 1, In : Biochemical Pharmacology. 154, p. 357-372 16 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Three new 5,6,7,8-tetrahydroxy-5,6,7,8-tetrahydrochromone derivatives enantiomeric to agarotetrol from agarwood

Sugiyama, T., Narukawa, Y., Shibata, S., Masui, R. & Kiuchi, F., 2018 Mar 10, (Accepted/In press) In : Journal of Natural Medicines. p. 1-8 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017
11 Citations (Scopus)

Synthesis and biological evaluation of the natural product komaroviquinone and related compounds aiming at a potential therapeutic lead compound for high-risk multiple myeloma

Suto, Y., Sato, M., Fujimori, K., Kitabatake, S., Okayama, M., Ichikawa, D., Matsushita, M., Yamagiwa, N., Iwasaki, G., Kiuchi, F. & Hattori, Y., 2017 Oct 1, In : Bioorganic and Medicinal Chemistry Letters. 27, 19, p. 4558-4563 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2016
8 Citations (Scopus)

Erratum to: LC-MS-based quantification method for Achyranthes root saponins

Kawahara, Y., Hoshino, T., Morimoto, H., Shimizu, T., Narukawa, Y., Fuchino, H., Kawahara, N. & Kiuchi, F., 2016 Apr 1, In : Journal of Natural Medicines. 70, 2, p. 300 1 p.

Research output: Contribution to journalArticle

Inhibitory effects of flavonoids extracted from Nepalese propolis on the LPS signaling pathway

Tago, M., Ohsawa, K., Ishikawa, T., Nakamura, F., Ueda, F., Narukawa, Y., Kiuchi, F., Tamura, H., Tago, K. & Kasahara, T., 2016 Nov 1, In : International Immunopharmacology. 40, p. 550-560 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

LC-MS-based quantification method for Achyranthes root saponins

Kawahara, Y., Hoshino, T., Morimoto, H., Shinizu, T., Narukawa, Y., Fuchino, H., Kawahara, N. & Kiuchi, F., 2016 Jan 1, In : Journal of Natural Medicines. 70, 1, p. 102-106 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

New 2-(2-Phenylethyl)chromone Derivatives and Inhibitors of Phosphodiesterase (PDE) 3A from Agarwood

Sugiyama, T., Narukawa, Y., Shibata, S., Masui, R. & Kiuchi, F., 2016 Jun 1, In : Natural Product Communications. 11, 6, p. 795-797 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Synthesis and antigenicity against human sera of a biotin-labeled oligosaccharide portion of a glycosphingolipid from the parasite Echinococcus multilocularis

Hada, N., Kitamura, A., Yamano, K., Schweizer, F. & Kiuchi, F., 2016, In : Chemical and Pharmaceutical Bulletin. 64, 7, p. 865-873 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Two new lignans and melanogenesis inhibitors from Schisandra nigra

Narukawa, Y., Komatsu, C., Yamauchi, R., Shibayama, S., Hachisuka, M. & Kiuchi, F., 2016 May 3, (Accepted/In press) In : Journal of Natural Medicines. p. 1-7 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2015

Anti-inflammatory activity of flavonoids in Nepalese propolis is attributed to inhibition of the IL-33 signaling pathway

Funakoshi-Tago, M., Okamoto, K., Izumi, R., Tago, K., Yanagisawa, K., Narukawa, Y., Kiuchi, F., Kasahara, T. & Tamura, H., 2015 Mar, In : International Immunopharmacology. 25, 1, p. 189-198 10 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Nepetaefuran and leonotinin isolated from Leonotis nepetaefolia R. Br. potently inhibit the LPS signaling pathway by suppressing the transactivation of NF-κB

Ueda, F., Iizuka, K., Tago, K., Narukawa, Y., Kiuchi, F., Kasahara, T., Tamura, H. & Tago, M., 2015 Oct 1, In : International Immunopharmacology. 28, 2, p. 967-976 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Novel monoterpene lactones from Cinnamomum inunctum

Fuchino, H., Yazawa, A., Kiuchi, F., Kawahara, N., Takahashi, Y. & Satake, M., 2015 Oct 1, In : Chemical and Pharmaceutical Bulletin. 63, 10, p. 833-836 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Scillapersicene: a new homoisoflavonoid with cytotoxic activity from the bulbs of Scilla persica HAUSSKN

Hafez Ghoran, S., Saeidnia, S., Babaei, E., Kiuchi, F. & Hussain, H., 2015 Jun 30, (Accepted/In press) In : Natural Product Research.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Synthesis of model compounds related to linear β-d-(1→6)-galactosyl side-chains of polysaccharides from astragalus mongholicus bunge

Hada, N., Shimura, R., Hakamata, K., Kiyohara, H., Yamada, H., Takeda, A. & Kiuchi, F., 2015, In : Heterocycles. 90, 1, p. 563-578 16 p.

Research output: Contribution to journalArticle

2014

Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN

Hafez Ghoran, S., Saeidnia, S., Babaei, E., Kiuchi, F., Dusek, M., Eigner, V., Dehno Khalaji, A. & Soltani, A., 2014 Dec, In : Bioorganic Chemistry. 57, p. 51-56 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

New diterpenoids with estrogen sulfotransferase inhibitory activity from Leonurus sibiricus L

Narukawa, Y., Niimura, A., Noguchi, H., Tamura, H. & Kiuchi, F., 2014 Jan 1, In : Journal of Natural Medicines. 68, 1, p. 125-131 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Synthetic studies on glycosphingolipids from protostomia phyla: Synthesis of glycosphingolipid from the marine sponge Spheciospongia vesparia and its analogue

Hada, N., Miyamura, A., Ohtsuka, I. & Kiuchi, F., 2014, In : Heterocycles. 88, 1, p. 689-704 16 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2013

Collagenase inhibitors from Viola yedoensis

Oshima, N., Narukawa, Y., Takeda, T. & Kiuchi, F., 2013 Jan 1, In : Journal of Natural Medicines. 67, 1, p. 240-245 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

New leishmanicidal stilbenes from a peruvian folk medicine, Lonchocarpus nicou

Fuchino, H., Kiuchi, F., Yamanaka, A., Obu, A., Wada, H., Mori-Yasumoto, K., Kawahara, N., Flores, D., Palacios, O., Sekita, S. & Satake, M., 2013 Sep 1, In : Chemical and Pharmaceutical Bulletin. 61, 9, p. 979-982 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
16 Citations (Scopus)

Two new sulfated oleanan saponins from Achyranthes root

Hoshino, T., Narukawa, Y., Haishima, Y., Goda, Y. & Kiuchi, F., 2013 Apr 1, In : Journal of Natural Medicines. 67, 2, p. 386-389 4 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2012

Galα1-4Galβ1-3GalNAc is the dominant epitope of Em2 antigen, the mucin-type glycoprotein from Echinococcus multilocularis

Yamano, K., Koizumi, A., Takeda, T., Kiuchi, F. & Hada, N., 2012 Aug 1, In : Parasitology Research. 111, 2, p. 795-805 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Genetic and phenotypic analyses of a papaver somniferum T-DNA insertional mutant with altered alkaloid composition

Kawano, N., Kiuchi, F., Kawahara, N. & Yoshimatsu, K., 2012 Feb 14, In : Pharmaceuticals. 5, 2, p. 133-154 22 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Improvement of benzylisoquinoline alkaloid productivity by overexpression of 3′-hydroxy-N-methylcoclaurine 4′-O-methyltransferase in transgenic Coptis japonica plants

Inui, T., Kawano, N., Shitan, N., Yazaki, K., Kiuchi, F., Kawahara, N., Sato, F. & Yoshimatsu, K., 2012 May 1, In : Biological and Pharmaceutical Bulletin. 35, 5, p. 650-659 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Sulfatides inhibit adhesion, migration, and invasion of murine melanoma B16F10 cell line in vitro

Ozawa, H., Sonoda, Y., Kato, S., Suzuki, E., Matsuoka, R., Kanaya, T., Kiuchi, F., Hada, N. & Kasahara, T., 2012 Nov 1, In : Biological and Pharmaceutical Bulletin. 35, 11, p. 2054-2058 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Synthesis, antigenicity against human sera and structure-activity relationships of carbohydrate moieties from toxocara larvae and their analogues

Koizumi, A., Yamano, K., Tsuchiya, T., Schweizer, F., Kiuchi, F. & Hada, N., 2012 Aug 1, In : Molecules. 17, 8, p. 9023-9042 20 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Synthetic studies on glycosphingolipids from protostomia phyla: Synthesis of glycosphingolipids and related carbohydrate moieties from the parasite Schistosoma mansoni

Kanaya, T., Schweizer, F., Takeda, T., Kiuchi, F. & Hada, N., 2012 Nov 1, In : Carbohydrate Research. 361, p. 55-72 18 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2011

Evaluation of the taste of crude drug and kampo formula by a taste-sensing system (4): Taste of processed aconite root

Anjiki, N., Hosoe, J., Fuchino, H., Kiuchi, F., Sekita, S., Ikezaki, H., Mikage, M., Kawahara, N. & Goda, Y., 2011 Apr 1, In : Journal of Natural Medicines. 65, 2, p. 293-300 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Synthesis, inhibitory effects on nitric oxide and structure-activity relationships of a glycosphingolipid from the marine sponge Aplysinella rhax and its analogues

Fujita, Y., Ohshima, N., Hasegawa, A., Schweizer, F., Takeda, T., Kiuchi, F. & Hada, N., 2011 Jan 1, In : Molecules. 16, 1, p. 637-651 15 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Synthesis of the carbohydrate moiety from the parasite Echinococcus multilocularis and their antigenicity against human sera

Koizumi, A., Yamano, K., Schweizer, F., Takeda, T., Kiuchi, F. & Hada, N., 2011 May 1, In : European Journal of Medicinal Chemistry. 46, 5, p. 1768-1778 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2010

Genetic and chemical comparison of Boi (Sinomeni Caulis et Rhizoma) and Seifuto (Caulis Sinomenii)

Sano, T., Matsumura, I., Nakamura, R., Yamaji, H., Hashimoto, K., Takeda, O., Kiuchi, F. & Takeda, T., 2010 Jul 1, In : Journal of Natural Medicines. 64, 3, p. 257-265 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

In vitro leishmanicidal activity of benzophenanthridine alkaloids from Bocconia pearcei and related compounds

Fuchino, H., Kawano, M., Mori-Yasumoto, K., Sekita, S., Satake, M., Ishikawa, T., Kiuchi, F. & Kawahara, N., 2010 Aug 1, In : Chemical and Pharmaceutical Bulletin. 58, 8, p. 1047-1050 4 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Synthetic studies on glycosphingolipids from protostomia phyla: Synthesis of glycosphingolipids from the parasite Schistosoma mansoni

Kanaya, T., Yagi, S., Schweizer, F., Takeda, T., Kiuchi, F. & Hada, N., 2010 Jun, In : Chemical and Pharmaceutical Bulletin. 58, 6, p. 811-817 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2009

A guanidine derivative from seeds of Plantago asiatica

Goda, Y., Kawahara, N., Kiuchi, F., Hirakura, K., Kikuchi, Y., Nishimura, H., Takao, M., Marumoto, M. & Kitazaki, H., 2009 Jan 1, In : Journal of Natural Medicines. 63, 1, p. 58-60 3 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2008

A new leishmanicidal saponin from Brunfelsia grandiflora

Fuchino, H., Sekita, S., Mori, K., Kawahara, N., Satake, M. & Kiuchi, F., 2008 Jan 1, In : Chemical and Pharmaceutical Bulletin. 56, 1, p. 93-96 4 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

A new phenolic glucoside from an Uzbek medicinal plant, Origanum tyttanthum

Takeda, Y., Tomonari, M., Arimoto, S., Masuda, T., Otsuka, H., Matsunami, K., Honda, G., Ito, M., Takaishi, Y., Kiuchi, F., Khodzhimatov, O. K. & Ashurmetov, O. A., 2008 Jan 1, In : Journal of Natural Medicines. 62, 1, p. 71-74 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum

Yagura, T., Motomiya, T., Ito, M., Honda, G., Iida, A., Kiuchi, F., Tokuda, H. & Nishino, H., 2008 Apr 1, In : Journal of Natural Medicines. 62, 2, p. 174-178 5 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Detection method for the ability of hemp (Cannabis sativa L.) seed germination by the use of 2,3,5-triphenyl-2H-tetrazolium chloride (TTC)

Ogata, J., Kikura-Hanajiri, R., Yoshimatsu, K., Kiuchi, F. & Goda, Y., 2008 Nov 1, In : Yakugaku Zasshi. 128, 11, p. 1707-1711 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2006

Circular dichroism in a chiral amide possessing an achiral binaphthyl chromophore

Hosoi, S., Serata, J., Sakushima, A., Kiuchi, F., Takahashi, I. & Ohta, T., 2006 Jan 1, In : Letters in Organic Chemistry. 3, 1, p. 58-61 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

In vitro leishmanicidal constituents of Millettia pendula

Takahashi, M., Fuchino, H., Sekita, S., Satake, M. & Kiuchi, F., 2006 Jun 1, In : Chemical and Pharmaceutical Bulletin. 54, 6, p. 915-917 3 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Trypanocidal constituents of Dracocephalum komarovi

Uchiyama, N., Kiuchi, F., Ito, M., Honda, G., Takeda, Y., Khodzhimatov, O. K. & Ashurmetov, O. A., 2006 May 1, In : Tetrahedron. 62, 18, p. 4355-4359 5 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2005

Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme

Uchiyama, N., Kabututu, Z., Kubata, B. K., Kiuchi, F., Ito, M., Nakajima-Shimada, J., Aoki, T., Ohkubo, K., Fukuzumi, S., Martin, S. K., Honda, G. & Urade, Y., 2005 Dec 1, In : Antimicrobial Agents and Chemotherapy. 49, 12, p. 5123-5126 4 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)