• 3313 Citations
  • 31 h-Index
1981 …2019
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Research Output 1981 2019

  • 3313 Citations
  • 31 h-Index
  • 160 Article
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Article
2019

LC–MS analysis of saponins of Achyranthes root in the Japanese market

Kuwada, K., Kawase, S., Nakata, K., Shinya, N., Narukawa, Y., Fuchino, H., Kawahara, N. & Kiuchi, F., 2019 Jan 1, (Accepted/In press) In : Journal of Natural Medicines.

Research output: Contribution to journalArticle

Achyranthes
Saponins
1-Butanol
Water
Peroxides

Synthesis of the Non Reducing End Oligosaccharides of Glycosphingolipids from Ascaris suum

Hada, N., Umeda, Y., Kumada, H., Shimazaki, Y., Yamano, K., Schweizer, F., Oshima, N., Takeda, T. & Kiuchi, F., 2019 Jan 1, In : Chemical & pharmaceutical bulletin. 67, 2, p. 143-154 12 p.

Research output: Contribution to journalArticle

Ascaris suum
Glycosphingolipids
Oligosaccharides
Biotin
Galactose
2018

A novel derivative (GTN024) from a natural product, komaroviquinone, induced the apoptosis of high-risk myeloma cells via reactive oxygen production and ER stress

Okayama, M., Kitabatake, S., Sato, M., Fujimori, K., Ichikawa, D., Matsushita, M., Suto, Y., Iwasaki, G., Yamada, T., Kiuchi, F., Hirao, M., Kunieda, H., Osada, M., Okamoto, S. & Hattori, Y., 2018 Nov 2, In : Biochemical and Biophysical Research Communications. 505, 3, p. 787-793 7 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Biological Products
Multiple Myeloma
Apoptosis
Oxygen
1 Citation (Scopus)
1-Octanol
theaflavins
octanol
Monophenol Monooxygenase
Catechin

Preparation of menisdaurigenin and related compounds

Shirakawa, R., Ishikawa, S., Takahasi, M., Ueno, Y., Uekusa, Y., Narukawa, Y., Sugai, T. & Kiuchi, F., 2018 Jan 1, (Accepted/In press) In : Journal of Natural Medicines.

Research output: Contribution to journalArticle

Stereochemistry
Hydrolysis
Enzymatic hydrolysis
Menispermum
Cocculus
2 Citations (Scopus)

Quantitative analysis of the anti-inflammatory activity of orengedokuto II: berberine is responsible for the inhibition of NO production

Oshima, N., Shimizu, T., Narukawa, Y., Hada, N. & Kiuchi, F., 2018 Apr 18, (Accepted/In press) In : Journal of Natural Medicines. p. 1-9 9 p.

Research output: Contribution to journalArticle

Berberine
Scutellaria
Phellodendron
Nitric Oxide
Anti-Inflammatory Agents
6 Citations (Scopus)

Taxodione induces apoptosis in BCR-ABL-positive cells through ROS generation

Uchihara, Y., Tago, K., Taguchi, H., Narukawa, Y., Kiuchi, F., Tamura, H. & Tago, M., 2018 Aug 1, In : Biochemical Pharmacology. 154, p. 357-372 16 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Cells
Apoptosis
Leukemia
K562 Cells

Three new 5,6,7,8-tetrahydroxy-5,6,7,8-tetrahydrochromone derivatives enantiomeric to agarotetrol from agarwood

Sugiyama, T., Narukawa, Y., Shibata, S., Masui, R. & Kiuchi, F., 2018 Mar 10, (Accepted/In press) In : Journal of Natural Medicines. p. 1-8 8 p.

Research output: Contribution to journalArticle

Thymelaeaceae
Type 3 Cyclic Nucleotide Phosphodiesterases
Chromones
Derivatives
Stereochemistry
2017
10 Citations (Scopus)
Scutellaria
Flavonoids
Anti-Inflammatory Agents
Dinoprostone
Messenger RNA
2 Citations (Scopus)

Synthesis and biological evaluation of the natural product komaroviquinone and related compounds aiming at a potential therapeutic lead compound for high-risk multiple myeloma

Suto, Y., Sato, M., Fujimori, K., Kitabatake, S., Okayama, M., Ichikawa, D., Matsushita, M., Yamagiwa, N., Iwasaki, G., Kiuchi, F. & Hattori, Y., 2017 Oct 1, In : Bioorganic and Medicinal Chemistry Letters. 27, 19, p. 4558-4563 6 p.

Research output: Contribution to journalArticle

Lead compounds
Biological Products
Multiple Myeloma
Pharmaceutical Preparations
Proteasome Inhibitors
2016
6 Citations (Scopus)
Scutellaria
Principal Component Analysis
Dinoprostone
Flavonoids
Principal component analysis

Erratum to: LC-MS-based quantification method for Achyranthes root saponins

Kawahara, Y., Hoshino, T., Morimoto, H., Shimizu, T., Narukawa, Y., Fuchino, H., Kawahara, N. & Kiuchi, F., 2016 Apr 1, In : Journal of Natural Medicines. 70, 2, p. 300 1 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Inhibitory effects of flavonoids extracted from Nepalese propolis on the LPS signaling pathway

Tago, M., Ohsawa, K., Ishikawa, T., Nakamura, F., Ueda, F., Narukawa, Y., Kiuchi, F., Tamura, H., Tago, K. & Kasahara, T., 2016 Nov 1, In : International Immunopharmacology. 40, p. 550-560 11 p.

Research output: Contribution to journalArticle

Propolis
Flavonoids
Anti-Inflammatory Agents
Messenger RNA
Transcription Factors
7 Citations (Scopus)

LC-MS-based quantification method for Achyranthes root saponins

Kawahara, Y., Hoshino, T., Morimoto, H., Shinizu, T., Narukawa, Y., Fuchino, H., Kawahara, N. & Kiuchi, F., 2016 Jan 1, In : Journal of Natural Medicines. 70, 1, p. 102-106 5 p.

Research output: Contribution to journalArticle

Achyranthes
Saponins
Liquid chromatography
Liquid Chromatography
Mass spectrometry
2 Citations (Scopus)

New 2-(2-Phenylethyl)chromone Derivatives and Inhibitors of Phosphodiesterase (PDE) 3A from Agarwood

Sugiyama, T., Narukawa, Y., Shibata, S., Masui, R. & Kiuchi, F., 2016 Jun 1, In : Natural Product Communications. 11, 6, p. 795-797 3 p.

Research output: Contribution to journalArticle

Type 3 Cyclic Nucleotide Phosphodiesterases
chemical derivatives
extracts
Chromones
inhibitory concentration 50
1 Citation (Scopus)

Synthesis and antigenicity against human sera of a biotin-labeled oligosaccharide portion of a glycosphingolipid from the parasite Echinococcus multilocularis

Hada, N., Kitamura, A., Yamano, K., Schweizer, F. & Kiuchi, F., 2016, In : Chemical and Pharmaceutical Bulletin. 64, 7, p. 865-873 9 p.

Research output: Contribution to journalArticle

Echinococcus multilocularis
Glycosphingolipids
Biotin
Oligosaccharides
Parasites
4 Citations (Scopus)

Two new lignans and melanogenesis inhibitors from Schisandra nigra

Narukawa, Y., Komatsu, C., Yamauchi, R., Shibayama, S., Hachisuka, M. & Kiuchi, F., 2016 May 3, (Accepted/In press) In : Journal of Natural Medicines. p. 1-7 7 p.

Research output: Contribution to journalArticle

Schisandra
Lignans
Experimental Melanomas
Monophenol Monooxygenase
Schisandraceae
2015
30 Citations (Scopus)

Anti-inflammatory activity of flavonoids in Nepalese propolis is attributed to inhibition of the IL-33 signaling pathway

Tago, M., Okamoto, K., Izumi, R., Tago, K., Yanagisawa, K., Narukawa, Y., Kiuchi, F., Kasahara, T. & Tamura, H., 2015, In : International Immunopharmacology. 25, 1, p. 189-198 10 p.

Research output: Contribution to journalArticle

Propolis
Flavonoids
Anti-Inflammatory Agents
Cytokines
Interleukin-13
4 Citations (Scopus)
Lamiaceae
Transcriptional Activation
Anti-Inflammatory Agents
Lions
Messenger RNA
2 Citations (Scopus)

Novel monoterpene lactones from Cinnamomum inunctum

Fuchino, H., Yazawa, A., Kiuchi, F., Kawahara, N., Takahashi, Y. & Satake, M., 2015 Oct 1, In : Chemical and Pharmaceutical Bulletin. 63, 10, p. 833-836 4 p.

Research output: Contribution to journalArticle

Cinnamomum
4-Butyrolactone
Myanmar
Monoterpenes
Spironolactone
5 Citations (Scopus)

Scillapersicene: a new homoisoflavonoid with cytotoxic activity from the bulbs of Scilla persica HAUSSKN

Hafez Ghoran, S., Saeidnia, S., Babaei, E., Kiuchi, F. & Hussain, H., 2015 Jun 30, (Accepted/In press) In : Natural Product Research.

Research output: Contribution to journalArticle

Scilla
bulbs
Energy gap
Cells
cell lines

Synthesis of model compounds related to linear β-d-(1→6)-galactosyl side-chains of polysaccharides from astragalus mongholicus bunge

Hada, N., Shimura, R., Hakamata, K., Kiyohara, H., Yamada, H., Takeda, A. & Kiuchi, F., 2015, In : Heterocycles. 90, 1, p. 563-578 16 p.

Research output: Contribution to journalArticle

Galactans
Glycosylation
Polysaccharides
2014
4 Citations (Scopus)

Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN

Hafez Ghoran, S., Saeidnia, S., Babaei, E., Kiuchi, F., Dusek, M., Eigner, V., Dehno Khalaji, A. & Soltani, A., 2014, In : Bioorganic Chemistry. 57, p. 51-56 6 p.

Research output: Contribution to journalArticle

Scilla
Single crystals
X ray crystallography
X Ray Crystallography
X ray analysis
17 Citations (Scopus)

New diterpenoids with estrogen sulfotransferase inhibitory activity from Leonurus sibiricus L

Narukawa, Y., Niimura, A., Noguchi, H., Tamura, H. & Kiuchi, F., 2014 Jan, In : Journal of Natural Medicines. 68, 1, p. 125-131 7 p.

Research output: Contribution to journalArticle

Leonurus
Diterpenes
Meclofenamic Acid
Acetone
Human Activities
3 Citations (Scopus)

Synthetic studies on glycosphingolipids from protostomia phyla: Synthesis of glycosphingolipid from the marine sponge Spheciospongia vesparia and its analogue

Hada, N., Miyamura, A., Ohtsuka, I. & Kiuchi, F., 2014, In : Heterocycles. 88, 1, p. 689-704 16 p.

Research output: Contribution to journalArticle

Neutral Glycosphingolipids
Glycosphingolipids
Monosaccharides
Disaccharides
Porifera
3 Citations (Scopus)

Two new diterpenoids from Leonotis leonurus R. Br.

Narukawa, Y., Komori, M., Niimura, A., Noguchi, H. & Kiuchi, F., 2014, In : Journal of Natural Medicines. 69, 1, p. 130-134 5 p.

Research output: Contribution to journalArticle

Leonurus
Lamiaceae
Diterpenes
Antennas
2013
7 Citations (Scopus)

Collagenase inhibitors from Viola yedoensis

Oshima, N., Narukawa, Y., Takeda, T. & Kiuchi, F., 2013 Jan, In : Journal of Natural Medicines. 67, 1, p. 240-245 6 p.

Research output: Contribution to journalArticle

scoparone
Microbial Collagenase
Viola
homoorientin
Matrix Metalloproteinase Inhibitors
2 Citations (Scopus)

New leishmanicidal stilbenes from a peruvian folk medicine, Lonchocarpus nicou

Fuchino, H., Kiuchi, F., Yamanaka, A., Obu, A., Wada, H., Mori-Yasumoto, K., Kawahara, N., Flores, D., Palacios, O., Sekita, S. & Satake, M., 2013 Sep, In : Chemical and Pharmaceutical Bulletin. 61, 9, p. 979-982 4 p.

Research output: Contribution to journalArticle

Stilbenes
Traditional Medicine
Medicine
Inhibitory Concentration 50
14 Citations (Scopus)
Scutellaria
Macrophages
Dinoprostone
Flavonoids
Inhibitory Concentration 50
7 Citations (Scopus)

Two new sulfated oleanan saponins from Achyranthes root

Hoshino, T., Narukawa, Y., Haishima, Y., Goda, Y. & Kiuchi, F., 2013 Apr, In : Journal of Natural Medicines. 67, 2, p. 386-389 4 p.

Research output: Contribution to journalArticle

Achyranthes
Oleanolic Acid
Saponins
Carboxylic Acids
Sulfates
2012
12 Citations (Scopus)

Galα1-4Galβ1-3GalNAc is the dominant epitope of Em2 antigen, the mucin-type glycoprotein from Echinococcus multilocularis

Yamano, K., Koizumi, A., Takeda, T., Kiuchi, F. & Hada, N., 2012 Aug, In : Parasitology Research. 111, 2, p. 795-805 11 p.

Research output: Contribution to journalArticle

Echinococcus multilocularis
mucins
Mucins
epitopes
glycoproteins
3 Citations (Scopus)

Genetic and phenotypic analyses of a papaver somniferum T-DNA insertional mutant with altered alkaloid composition

Kawano, N., Kiuchi, F., Kawahara, N. & Yoshimatsu, K., 2012, In : Pharmaceuticals. 5, 2, p. 133-154 22 p.

Research output: Contribution to journalArticle

Papaver
Thebaine
Alkaloids
Opium
Polymerase Chain Reaction
10 Citations (Scopus)

Improvement of benzylisoquinoline alkaloid productivity by overexpression of 3′-hydroxy-N-methylcoclaurine 4′-O-methyltransferase in transgenic Coptis japonica plants

Inui, T., Kawano, N., Shitan, N., Yazaki, K., Kiuchi, F., Kawahara, N., Sato, F. & Yoshimatsu, K., 2012 May, In : Biological and Pharmaceutical Bulletin. 35, 5, p. 650-659 10 p.

Research output: Contribution to journalArticle

Coptis
Benzylisoquinolines
Berberine
Methyltransferases
Alkaloids
4 Citations (Scopus)

Sulfatides inhibit adhesion, migration, and invasion of murine melanoma B16F10 cell line in vitro

Ozawa, H., Sonoda, Y., Kato, S., Suzuki, E., Matsuoka, R., Kanaya, T., Kiuchi, F., Hada, N. & Kasahara, T., 2012 Nov, In : Biological and Pharmaceutical Bulletin. 35, 11, p. 2054-2058 5 p.

Research output: Contribution to journalArticle

Sulfoglycosphingolipids
Melanoma
Glucosylceramides
Cell Line
Cell Movement
9 Citations (Scopus)

Synthesis, antigenicity against human sera and structure-activity relationships of carbohydrate moieties from toxocara larvae and their analogues

Koizumi, A., Yamano, K., Tsuchiya, T., Schweizer, F., Kiuchi, F. & Hada, N., 2012 Aug, In : Molecules. 17, 8, p. 9023-9042 20 p.

Research output: Contribution to journalArticle

Toxocara
larvae
carbohydrates
Structure-Activity Relationship
Oligosaccharides
8 Citations (Scopus)

Synthetic studies on glycosphingolipids from protostomia phyla: Synthesis of glycosphingolipids and related carbohydrate moieties from the parasite Schistosoma mansoni

Kanaya, T., Schweizer, F., Takeda, T., Kiuchi, F. & Hada, N., 2012 Nov 1, In : Carbohydrate Research. 361, p. 55-72 18 p.

Research output: Contribution to journalArticle

Glycosphingolipids
Schistosoma mansoni
Parasites
Carbohydrates
Oligosaccharides
2011
59 Citations (Scopus)

A review on phytochemistry and medicinal properties of the genus Achillea

Saeidnia, S., Gohari, A. R., Mokhber-Dezfuli, N. & Kiuchi, F., 2011, In : DARU, Journal of Pharmaceutical Sciences. 19, 3, p. 173-186 14 p.

Research output: Contribution to journalArticle

Achillea
Asteraceae
Phytochemicals
Coumarins
Triterpenes
13 Citations (Scopus)

Evaluation of the taste of crude drug and kampo formula by a taste-sensing system (4): Taste of processed aconite root

Anjiki, N., Hosoe, J., Fuchino, H., Kiuchi, F., Sekita, S., Ikezaki, H., Mikage, M., Kawahara, N. & Goda, Y., 2011 Apr, In : Journal of Natural Medicines. 65, 2, p. 293-300 8 p.

Research output: Contribution to journalArticle

Kampo Medicine
Aconitum
Pharmaceutical Preparations
Salts
Calcium Chloride
5 Citations (Scopus)

Synthesis, inhibitory effects on nitric oxide and structure-activity relationships of a glycosphingolipid from the marine sponge Aplysinella rhax and its analogues

Fujita, Y., Ohshima, N., Hasegawa, A., Schweizer, F., Takeda, T., Kiuchi, F. & Hada, N., 2011 Jan, In : Molecules. 16, 1, p. 637-651 15 p.

Research output: Contribution to journalArticle

Glycosphingolipids
Fucose
Porifera
Structure-Activity Relationship
nitric oxide
16 Citations (Scopus)

Synthesis of the carbohydrate moiety from the parasite Echinococcus multilocularis and their antigenicity against human sera

Koizumi, A., Yamano, K., Schweizer, F., Takeda, T., Kiuchi, F. & Hada, N., 2011 May, In : European Journal of Medicinal Chemistry. 46, 5, p. 1768-1778 11 p.

Research output: Contribution to journalArticle

Echinococcus multilocularis
Oligosaccharides
Parasites
Carbohydrates
Trisaccharides
2010
3 Citations (Scopus)

Genetic and chemical comparison of Boi (Sinomeni Caulis et Rhizoma) and Seifuto (Caulis Sinomenii)

Sano, T., Matsumura, I., Nakamura, R., Yamaji, H., Hashimoto, K., Takeda, O., Kiuchi, F. & Takeda, T., 2010 Jul, In : Journal of Natural Medicines. 64, 3, p. 257-265 9 p.

Research output: Contribution to journalArticle

Sinomenium
Genotype
Rhizome
Alkaloids
Nucleotides
28 Citations (Scopus)

In vitro leishmanicidal activity of benzophenanthridine alkaloids from Bocconia pearcei and related compounds

Fuchino, H., Kawano, M., Mori-Yasumoto, K., Sekita, S., Satake, M., Ishikawa, T., Kiuchi, F. & Kawahara, N., 2010 Aug, In : Chemical and Pharmaceutical Bulletin. 58, 8, p. 1047-1050 4 p.

Research output: Contribution to journalArticle

Benzophenanthridines
Alkaloids
Structure-Activity Relationship
Fruits
Skeleton
7 Citations (Scopus)

Synthetic studies on glycosphingolipids from protostomia phyla: Synthesis of glycosphingolipids from the parasite Schistosoma mansoni

Kanaya, T., Yagi, S., Schweizer, F., Takeda, T., Kiuchi, F. & Hada, N., 2010, In : Chemical and Pharmaceutical Bulletin. 58, 6, p. 811-817 7 p.

Research output: Contribution to journalArticle

Glycosphingolipids
Schistosoma mansoni
Parasites
Neutral Glycosphingolipids
2009
10 Citations (Scopus)

A guanidine derivative from seeds of Plantago asiatica

Goda, Y., Kawahara, N., Kiuchi, F., Hirakura, K., Kikuchi, Y., Nishimura, H., Takao, M., Marumoto, M. & Kitazaki, H., 2009 Jan, In : Journal of Natural Medicines. 63, 1, p. 58-60 3 p.

Research output: Contribution to journalArticle

Psyllium
Guanidine
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Derivatives
2008
20 Citations (Scopus)

A new leishmanicidal saponin from Brunfelsia grandiflora

Fuchino, H., Sekita, S., Mori, K., Kawahara, N., Satake, M. & Kiuchi, F., 2008 Jan, In : Chemical and Pharmaceutical Bulletin. 56, 1, p. 93-96 4 p.

Research output: Contribution to journalArticle

Leishmania major
Spectroscopic analysis
Saponins
Chemical reactions
In Vitro Techniques
7 Citations (Scopus)

A new phenolic glucoside from an Uzbek medicinal plant, Origanum tyttanthum

Takeda, Y., Tomonari, M., Arimoto, S., Masuda, T., Otsuka, H., Matsunami, K., Honda, G., Ito, M., Takaishi, Y., Kiuchi, F., Khodzhimatov, O. K. & Ashurmetov, O. A., 2008 Jan, In : Journal of Natural Medicines. 62, 1, p. 71-74 4 p.

Research output: Contribution to journalArticle

Origanum
Glucosides
Medicinal Plants
Hydroxyl Radical
Antennas
27 Citations (Scopus)

Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum

Yagura, T., Motomiya, T., Ito, M., Honda, G., Iida, A., Kiuchi, F., Tokuda, H. & Nishino, H., 2008 Apr, In : Journal of Natural Medicines. 62, 2, p. 174-178 5 p.

Research output: Contribution to journalArticle

Helichrysum
Medicinal Plants
Assays
Inbred SENCAR Mouse
Papilloma
4 Citations (Scopus)

Detection method for the ability of hemp (Cannabis sativa L.) seed germination by the use of 2,3,5-triphenyl-2H-tetrazolium chloride (TTC)

Ogata, J., Kikura-Hanajiri, R., Yoshimatsu, K., Kiuchi, F. & Goda, Y., 2008 Nov, In : Yakugaku Zasshi. 128, 11, p. 1707-1711 5 p.

Research output: Contribution to journalArticle

Cannabis
Germination
Seeds
Spices
Dronabinol
2006
4 Citations (Scopus)

Circular dichroism in a chiral amide possessing an achiral binaphthyl chromophore

Hosoi, S., Serata, J., Sakushima, A., Kiuchi, F., Takahashi, I. & Ohta, T., 2006 Jan, In : Letters in Organic Chemistry. 3, 1, p. 58-61 4 p.

Research output: Contribution to journalArticle

Methylation
Chirality
Dichroism
Chromophores
Circular Dichroism
21 Citations (Scopus)

In vitro leishmanicidal constituents of Millettia pendula

Takahashi, M., Fuchino, H., Sekita, S., Satake, M. & Kiuchi, F., 2006 Jun, In : Chemical and Pharmaceutical Bulletin. 54, 6, p. 915-917 3 p.

Research output: Contribution to journalArticle

Millettia
Pigments
Methanol
pendulone
In Vitro Techniques