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1982 …2020

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2020

A potent blood–brain barrier-permeable mutant IDH1 inhibitor suppresses the growth of glioblastoma with IDH1 mutation in a patient-derived orthotopic xenograft model

Machida, Y., Nakagawa, M., Matsunaga, H., Yamaguchi, M., Ogawara, Y., Shima, Y., Yamagata, K., Katsumoto, T., Hattori, A., Itoh, M., Seki, T., Nishiya, Y., Nakamura, K., Suzuki, K., Imaoka, T., Baba, D., Suzuki, M., Sampetrean, O., Saya, H., Ichimura, K. & 1 others, Kitabayashi, I., 2020 Feb, In : Molecular cancer therapeutics. 19, 2, p. 375-383 9 p.

Research output: Contribution to journalArticle

Gene Therapy Using Neural Stem/Progenitor Cells Derived from Human Induced Pluripotent Stem Cells: Visualization of Migration and Bystander Killing Effect

Tamura, R., Miyoshi, H., Morimoto, Y., Oishi, Y., Sampetrean, O., Iwasawa, C., Mine, Y., Saya, H., Yoshida, K., Okano, H. & Toda, M., 2020 Mar, In : Human Gene Therapy. 31, 5-6, p. 352-366 15 p.

Research output: Contribution to journalArticle

Open Access

Identification of kit-ligand a as the gene responsible for the medaka pigment cell mutant few melanophore

Otsuki, Y., Okuda, Y., Naruse, K. & Saya, H., 2020 Jan 1, In : G3: Genes, Genomes, Genetics. 10, 1, p. 311-319 9 p.

Research output: Contribution to journalArticle

Open Access

Overexpression of a panel of cancer stem cell markers enhances the predictive capability of the progression and recurrence in the early stage cholangiocarcinoma

Padthaisong, S., Thanee, M., Namwat, N., Phetcharaburanin, J., Klanrit, P., Khuntikeo, N., Titapun, A., Sungkhamanon, S., Saya, H. & Loilome, W., 2020 Feb 10, In : Journal of Translational Medicine. 18, 1, 64.

Research output: Contribution to journalArticle

Open Access

The insulin-PI3K-Rac1 axis contributes to terminal adipocyte differentiation through regulation of actin cytoskeleton dynamics

Kunitomi, H., Oki, Y., Onishi, N., Kano, K., Banno, K., Aoki, D., Saya, H. & Nobusue, H., 2020 Mar 1, In : Genes to Cells. 25, 3, p. 165-174 10 p.

Research output: Contribution to journalArticle

2019

Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori–Infected CAPZA1-Overexpressing Cells

Tsugawa, H., Kato, C., Mori, H., Matsuzaki, J., Kameyama, K., Saya, H., Hatakeyama, M., Suematsu, M. & Suzuki, H., 2019 Jan 1, In : CMGH. 8, 3, p. 319-334 16 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Endothelial-mesenchymal transition drives expression of CD44 variant and xCT in pulmonary hypertension

Isobe, S., Kataoka, M., Endo, J., Moriyama, H., Okazaki, S., Tsuchihashi, K., Katsumata, Y., Yamamoto, T., Shirakawa, K., Yoshida, N., Shimoda, M., Chiba, T., Masuko, T., Hakamata, Y., Kobayashi, E., Saya, H., Fukuda, K. & Sano, M., 2019 Jan 1, In : American journal of respiratory cell and molecular biology. 61, 3, p. 367-379 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors

Suzuki, K., Miura, Y., Mochida, Y., Miyazaki, T., Toh, K., Anraku, Y., Melo, V., Liu, X., Ishii, T., Nagano, O., Saya, H., Cabral, H. & Kataoka, K., 2019 May 10, In : Journal of Controlled Release. 301, p. 28-41 14 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma

Okazaki, S., Umene, K., Yamasaki, J., Suina, K., Otsuki, Y., Yoshikawa, M., Minami, Y., Masuko, T., Kawaguchi, S., Nakayama, H., Banno, K., Aoki, D., Saya, H. & Nagano, O., 2019 Nov 1, In : Cancer science. 110, 11, p. 3453-3463 11 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

Kofuji, S., Hirayama, A., Eberhardt, A. O., Kawaguchi, R., Sugiura, Y., Sampetrean, O., Ikeda, Y., Warren, M., Sakamoto, N., Kitahara, S., Yoshino, H., Yamashita, D., Sumita, K., Wolfe, K., Lange, L., Ikeda, S., Shimada, H., Minami, N., Malhotra, A., Morioka, S. & 37 others, Ban, Y., Asano, M., Flanary, V. L., Ramkissoon, A., Chow, L. M. L., Kiyokawa, J., Mashimo, T., Lucey, G., Mareninov, S., Ozawa, T., Onishi, N., Okumura, K., Terakawa, J., Daikoku, T., Wise-Draper, T., Majd, N., Kofuji, K., Sasaki, M., Mori, M., Kanemura, Y., Smith, E. P., Anastasiou, D., Wakimoto, H., Holland, E. C., Yong, W. H., Horbinski, C., Nakano, I., DeBerardinis, R. J., Bachoo, R. M., Mischel, P. S., Yasui, W., Suematsu, M., Saya, H., Soga, T., Grummt, I., Bierhoff, H. & Sasaki, A. T., 2019 Aug 1, In : Nature Cell Biology. 21, 8, p. 1003-1014 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Neuroprotective effects of memantine via enhancement of autophagy

Hirano, K., Fujimaki, M., Sasazawa, Y., Yamaguchi, A., Ishikawa, K. I., Miyamoto, K., Souma, S., Furuya, N., Imamichi, Y., Yamada, D., Saya, H., Akamatsu, W., Saiki, S. & Hattori, N., 2019 Oct 8, In : Biochemical and Biophysical Research Communications. 518, 1, p. 161-170 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

ROCK inhibition induces terminal adipocyte differentiation and suppresses tumorigenesis in chemoresistant osteosarcoma cells

Takahashi, N., Nobusue, H., Shimizu, T., Sugihara, E., Yamaguchi-Iwai, S., Onishi, N., Kunitomi, H., Kuroda, T. & Saya, H., 2019 Jun 15, In : Cancer Research. 79, 12, p. 3088-3099 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
Open Access
2 Citations (Scopus)

Sulfasalazine could modulate the CD44v9-xCT system and enhance cisplatin-induced cytotoxic effects in metastatic bladder cancer

Ogihara, K., Kikuchi, E., Okazaki, S., Hagiwara, M., Takeda, T., Matsumoto, K., Kosaka, T., Mikami, S., Saya, H. & Oya, M., 2019 Apr 1, In : Cancer Science. 110, 4, p. 1431-1441 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

The DNA topoisomerase II inhibitor amsacrine as a novel candidate adjuvant in a model of glaucoma filtration surgery

Yamamoto, K., Kokubun, T., Sato, K., Akaishi, T., Shimazaki, A., Nakamura, M., Shiga, Y., Tsuda, S., Omodaka, K., Saya, H. & Nakazawa, T., 2019 Dec 1, In : Scientific reports. 9, 1, 19288.

Research output: Contribution to journalArticle

Open Access

Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy

Otsuki, Y., Yamasaki, J., Suina, K., Okazaki, S., Koike, N., Saya, H. & Nagano, O., 2019 Jan 1, (Accepted/In press) In : Cancer science.

Research output: Contribution to journalArticle

Open Access

Visualization of spatiotemporal dynamics of human glioma stem cell invasion

Tamura, R., Miyoshi, H., Sampetrean, O., Shinozaki, M., Morimoto, Y., Iwasawa, C., Fukaya, R., Mine, Y., Masuda, H., Maruyama, T., Narita, M., Saya, H., Yoshida, K., Okano, H. & Toda, M., 2019 May 6, In : Molecular brain. 12, 1, 45.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
2018

An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment

Motohara, T., Masuda, K., Morotti, M., Zheng, Y., El-Sahhar, S., Chong, K. Y., Wietek, N., Alsaadi, A., Karaminejadranjbar, M., Hu, Z., Artibani, M., Gonzalez, L. S., Katabuchi, H., Saya, H. & Ahmed, A. A., 2018 Jan 1, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

10 Citations (Scopus)

CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake

Kobayashi, N., Okazaki, S., Sampetrean, O., Irie, J., Itoh, H. & Saya, H., 2018 Dec 1, In : Scientific Reports. 8, 1, 2785.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Development of a functional thyroid model based on an organoid culture system

Saito, Y., Onishi, N., Takami, H., Seishima, R., Inoue, H., Hirata, Y., Kameyama, K., Tsuchihashi, K., Sugihara, E., Uchino, S., Ito, K., Kawakubo, H., Takeuchi, H., Kitagawa, Y., Saya, H. & Nagano, O., 2018 Mar 4, In : Biochemical and Biophysical Research Communications. 497, 2, p. 783-789 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Dynamic changes in CD44v-positive cells after preoperative anti-HER2 therapy and its correlation with pathologic complete response in HER2-positive breast cancer

Yamauchi, T., Fernandez, J. R. E., Imamura, C. K., Yamauchi, H., Jinno, H., Takahashi, M., Kitagawa, Y., Nakamura, S., Lim, B., Krishnamurthy, S., Reuben, J. M., Liu, D., Tripathy, D., Chen, H., Takebe, N., Saya, H. & Ueno, N. T., 2018 Jan 1, In : Oncotarget. 9, 6, p. 6872-6882 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B-containing N-methyl-d-aspartate–sensitive glutamate receptor signaling

Suina, K., Tsuchihashi, K., Yamasaki, J., Kamenori, S., Shintani, S., Hirata, Y., Okazaki, S., Sampetrean, O., Baba, E., Akashi, K., Mitsuishi, Y., Takahashi, F., Takahashi, K., Saya, H. & Nagano, O., 2018 Jan 1, (Accepted/In press) In : Cancer Science.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival

Shiota, M., Naya, M., Yamamoto, T., Hishiki, T., Tani, T., Takahashi, H., Kubo, A., Koike, D., Itoh, M., Ohmura, M., Kabe, Y., Sugiura, Y., Hiraoka, N., Morikawa, T., Takubo, K., Suina, K., Nagashima, H., Sampetrean, O., Nagano, O., Saya, H. & 3 others, Yamazoe, S., Watanabe, H. & Suematsu, M., 2018 Dec 1, In : Nature Communications. 9, 1, 1561.

Research output: Contribution to journalArticle

25 Citations (Scopus)

HER2 heterogeneity is associated with poor survival in HER2-positive breast cancer

Hosonaga, M., Arima, Y., Sampetrean, O., Komura, D., Koya, I., Sasaki, T., Sato, E., Okano, H., Kudo, J., Ishikawa, S., Saya, H. & Ishikawa, T., 2018 Aug 1, In : International Journal of Molecular Sciences. 19, 8, 2158.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Inhibiting xCT improves 5-fluorouracil resistance of gastric cancer induced by CD44 variant 9 expression

Miyoshi, S., Tsugawa, H., Matsuzaki, J., Hirata, K., Mori, H., Saya, H., Kanai, T. & Suzuki, H., 2018 Nov 1, In : Anticancer Research. 38, 11, p. 6163-6170 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model

Shibao, S., Minami, N., Koike, N., Fukui, N., Yoshida, K., Saya, H. & Sampetrean, O., 2018 Feb 19, In : Neuro-Oncology. 20, 3, p. 343-354 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

Fujimori, K., Ishikawa, M., Otomo, A., Atsuta, N., Nakamura, R., Akiyama, T., Hadano, S., Aoki, M., Saya, H., Sobue, G. & Okano, H., 2018 Jan 1, (Accepted/In press) In : Nature Medicine.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Periostin antisense oligonucleotide suppresses bleomycin-induced formation of a lung premetastatic niche for melanoma

Semba, T., Sugihara, E., Kamoshita, N., Ueno, S., Fukuda, K., Yoshino, M., Takao, K., Yoshikawa, K., Izuhara, K., Arima, Y., Suzuki, M. & Saya, H., 2018 May, In : Cancer science. 109, 5, p. 1447-1454 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Recurrent Spindle Cell Carcinoma Shows Features of Mesenchymal Stem Cells

Ouchi, T., Morikawa, S., Shibata, S., Takahashi, M., Yoshikawa, M., Soma, T., Miyashita, H., Muraoka, W., Kameyama, K., Kawana, H., Arima, Y., Saya, H., Okano, H., Nakagawa, T. & Asoda, S., 2018 Feb 1, (Accepted/In press) In : Journal of Dental Research.

Research output: Contribution to journalArticle

Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells

Okazaki, S., Shintani, S., Hirata, Y., Suina, K., Semba, T., Yamasaki, J., Umene, K., Ishikawa, M., Saya, H. & Nagano, O., 2018 Sep 1, In : Oncotarget. 9, 73, p. 33832-33843 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Therapeutic potential of tranilast for the treatment of chronic graft-versus-host disease in mice

Mukai, S., Ogawa, Y., Saya, H., Kawakami, Y. & Tsubota, K., 2018 Oct 1, In : PLoS One. 13, 10, e0203742.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells

Harigai, R., Sakai, S., Nobusue, H., Hirose, C., Sampetrean, O., Minami, N., Hata, Y., Kasama, T., Hirose, T., Takenouchi, T., Kosaki, K., Kishi, K., Saya, H. & Arima, Y., 2018 Dec 1, In : Scientific reports. 8, 1, 6069.

Research output: Contribution to journalArticle

5 Citations (Scopus)

T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease

Tabata, Y., Imaizumi, Y., Sugawara, M., Andoh-Noda, T., Banno, S., Chai, M. C., Sone, T., Yamazaki, K., Ito, M., Tsukahara, K., Saya, H., Hattori, N., Kohyama, J. & Okano, H., 2018 Nov 13, In : Stem cell reports. 11, 5, p. 1171-1184 14 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
6 Citations (Scopus)
2017

Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells

Ishimoto, T., Miyake, K., Nandi, T., Yashiro, M., Onishi, N., Huang, K. K., Lin, S. J., Kalpana, R., Tay, S. T., Suzuki, Y., Cho, B. C., Kuroda, D., Arima, K., Izumi, D., Iwatsuki, M., Baba, Y., Oki, E., Watanabe, M., Saya, H., Hirakawa, K. & 2 others, Baba, H. & Tan, P., 2017 Jul 1, In : Gastroenterology. 153, 1, p. 191-204.e16

Research output: Contribution to journalArticle

41 Citations (Scopus)

Blocking COX-2 induces apoptosis and inhibits cell proliferation via the Akt/survivin- and Akt/ID3 pathway in low-grade-glioma

Sato, A., Mizobuchi, Y., Nakajima, K., Shono, K., Fujihara, T., Kageji, T., Kitazato, K., Matsuzaki, K., Mure, H., Kuwayama, K., Sumi, A., Saya, H., Sampetrean, O. & Nagahirao, S., 2017 Apr 1, In : Journal of Neuro-Oncology. 132, 2, p. 231-238 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Calcitriol exerts an anti-tumor effect in osteosarcoma by inducing the endoplasmic reticulum stress response

Shimizu, T., Kamel, W. A., Yamaguchi-Iwai, S., Fukuchi, Y., Muto, A. & Saya, H., 2017 Sep 1, In : Cancer Science. 108, 9, p. 1793-1802 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

CD44 variant–dependent regulation of redox balance in EGFR mutation–positive non–small cell lung cancer: A target for treatment

Kawano, Y., Iwama, E., Tsuchihashi, K., Shibahara, D., Harada, T., Tanaka, K., Nagano, O., Saya, H., Nakanishi, Y. & Okamoto, I., 2017 Nov 1, In : Lung Cancer. 113, p. 72-78 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Convection-enhanced delivery of sulfasalazine prolongs survival in a glioma stem cell brain tumor model

Haryu, S., Saito, R., Jia, W., Shoji, T., Mano, Y., Sato, A., Kanamori, M., Sonoda, Y., Sampetrean, O., Saya, H. & Tominaga, T., 2017 Sep 19, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-9 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells

Miyano, K., Cabral, H., Miura, Y., Matsumoto, Y., Mochida, Y., Kinoh, H., Iwata, C., Nagano, O., Saya, H., Nishiyama, N., Kataoka, K. & Yamasoba, T., 2017 Sep 10, In : Journal of Controlled Release. 261, p. 275-286 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Development of Highly Selective Fluorescent Probe Enabling Flow-Cytometric Isolation of ALDH3A1-Positive Viable Cells

Yagishita, A., Ueno, T., Esumi, H., Saya, H., Kaneko, K., Tsuchihara, K. & Urano, Y., 2017 Feb 15, In : Bioconjugate Chemistry. 28, 2, p. 302-306 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis

Jeong, S., Choi, E., Petersen, C. P., Roland, J. T., Federico, A., Ippolito, R., D'Armiento, F. P., Nardone, G., Nagano, O., Saya, H., Romano, M. & Goldenring, J. R., 2017, In : United European Gastroenterology Journal. 5, 1, p. 37-44 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality

Kitagawa, M., Liao, P. J., Lee, K. H., Wong, J., Shang, S. C., Minami, N., Sampetrean, O., Saya, H., Lingyun, D., Prabhu, N., Diam, G. K., Sobota, R., Larsson, A., Nordlund, P., McCormick, F., Ghosh, S., Epstein, D. M., Dymock, B. W. & Lee, S. H., 2017 Dec 1, In : Nature Communications. 8, 1, 2200.

Research output: Contribution to journalArticle

21 Citations (Scopus)
17 Citations (Scopus)

Establishment of pten knockout medaka with transcription activator–like effector nucleases (TALENs) as a model of PTEN deficiency disease

Matsuzaki, Y., Sakuma, T., Yamamoto, T. & Saya, H., 2017 Oct 1, In : PLoS One. 12, 10, e0186878.

Research output: Contribution to journalArticle

Functional analysis of the DEPDC1 oncoantigen in malignant glioma and brain tumor initiating cells

Kikuchi, R., Sampetrean, O., Saya, H., Yoshida, K. & Toda, M., 2017 May 29, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-11 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia

Ishizawa, J., Sugihara, E., Kuninaka, S., Mogushi, K., Kojima, K., Benton, C. B., Zhao, R., Chachad, D., Hashimoto, N., Jacamo, R. O., Qiu, Y., Yoo, S. Y., Okamoto, S., Andreeff, M., Kornblau, S. M. & Saya, H., 2017 Apr 6, In : Blood. 129, 14, p. 1958-1968 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression

Kasai, S., Furuichi, Y., Ando, N., Kagami, K., Abe, M., Nakane, T., Goi, K., Inukai, T., Saitoh, S., Ohno, S., Okazaki, S., Nagano, O., Saya, H. & Sugita, K., 2017 Jun 1, In : Cell death & disease. 8, 6, p. e2857

Research output: Contribution to journalArticle

5 Citations (Scopus)

Organotypic brain explant culture as a drug evaluation system for malignant brain tumors

Minami, N., Maeda, Y., Shibao, S., Arima, Y., Ohka, F., Kondo, Y., Maruyama, K., Kusuhara, M., Sasayama, T., Kohmura, E., Saya, H. & Sampetrean, O., 2017 Nov 1, In : Cancer Medicine. 6, 11, p. 2635-2645 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407)

Shitara, K., Doi, T., Nagano, O., Fukutani, M., Hasegawa, H., Nomura, S., Sato, A., Kuwata, T., Asai, K., Einaga, Y., Tsuchihashi, K., Suina, K., Maeda, Y., Saya, H. & Ohtsu, A., 2017 Nov 1, In : Gastric Cancer. 20, 6, p. 1004-1009 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)