• 18439 Citations
  • 72 h-Index
1982 …2020
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Research Output 1982 2020

  • 18439 Citations
  • 72 h-Index
  • 409 Article
  • 2 Chapter
  • 2 Review article
  • 1 Conference contribution
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Article
2020

Identification of kit-ligand a as the gene responsible for the medaka pigment cell mutant few melanophore

Otsuki, Y., Okuda, Y., Naruse, K. & Saya, H., 2020 Jan 1, In : G3: Genes, Genomes, Genetics. 10, 1, p. 311-319 9 p.

Research output: Contribution to journalArticle

Open Access
Melanophores
Oryzias
Stem Cell Factor
Genes
Piebaldism
2019
1 Citation (Scopus)

Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori–Infected CAPZA1-Overexpressing Cells

Tsugawa, H., Kato, C., Mori, H., Matsuzaki, J., Kameyama, K., Saya, H., Hatakeyama, M., Suematsu, M. & Suzuki, H., 2019 Jan 1, In : CMGH. 8, 3, p. 319-334 16 p.

Research output: Contribution to journalArticle

Open Access
Helicobacter
Neoplastic Stem Cells
Catenins
Protein Splicing
Histones
2 Citations (Scopus)

Endothelial-mesenchymal transition drives expression of CD44 variant and xCT in pulmonary hypertension

Isobe, S., Kataoka, M., Endo, J., Moriyama, H., Okazaki, S., Tsuchihashi, K., Katsumata, Y., Yamamoto, T., Shirakawa, K., Yoshida, N., Shimoda, M., Chiba, T., Masuko, T., Hakamata, Y., Kobayashi, E., Saya, H., Fukuda, K. & Sano, M., 2019 Jan 1, In : American journal of respiratory cell and molecular biology. 61, 3, p. 367-379 13 p.

Research output: Contribution to journalArticle

Sulfasalazine
Pulmonary Hypertension
Glutathione
Antioxidants
Chemotherapy
4 Citations (Scopus)

Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors

Suzuki, K., Miura, Y., Mochida, Y., Miyazaki, T., Toh, K., Anraku, Y., Melo, V., Liu, X., Ishii, T., Nagano, O., Saya, H., Cabral, H. & Kataoka, K., 2019 May 10, In : Journal of Controlled Release. 301, p. 28-41 14 p.

Research output: Contribution to journalArticle

Nanomedicine
Facilitative Glucose Transport Proteins
Blood Vessels
Micelles
Neoplasms
1 Citation (Scopus)

Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma

Okazaki, S., Umene, K., Yamasaki, J., Suina, K., Otsuki, Y., Yoshikawa, M., Minami, Y., Masuko, T., Kawaguchi, S., Nakayama, H., Banno, K., Aoki, D., Saya, H. & Nagano, O., 2019 Nov 1, In : Cancer science. 110, 11, p. 3453-3463 11 p.

Research output: Contribution to journalArticle

Open Access
Sulfasalazine
Glutamate Dehydrogenase
Glutamine
Genes
Neoplasms
4 Citations (Scopus)

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

Kofuji, S., Hirayama, A., Eberhardt, A. O., Kawaguchi, R., Sugiura, Y., Sampetrean, O., Ikeda, Y., Warren, M., Sakamoto, N., Kitahara, S., Yoshino, H., Yamashita, D., Sumita, K., Wolfe, K., Lange, L., Ikeda, S., Shimada, H., Minami, N., Malhotra, A., Morioka, S. & 37 others, Ban, Y., Asano, M., Flanary, V. L., Ramkissoon, A., Chow, L. M. L., Kiyokawa, J., Mashimo, T., Lucey, G., Mareninov, S., Ozawa, T., Onishi, N., Okumura, K., Terakawa, J., Daikoku, T., Wise-Draper, T., Majd, N., Kofuji, K., Sasaki, M., Mori, M., Kanemura, Y., Smith, E. P., Anastasiou, D., Wakimoto, H., Holland, E. C., Yong, W. H., Horbinski, C., Nakano, I., DeBerardinis, R. J., Bachoo, R. M., Mischel, P. S., Yasui, W., Suematsu, M., Saya, H., Soga, T., Grummt, I., Bierhoff, H. & Sasaki, A. T., 2019 Aug 1, In : Nature Cell Biology. 21, 8, p. 1003-1014 12 p.

Research output: Contribution to journalArticle

IMP Dehydrogenase
Glioblastoma
Carcinogenesis
Transfer RNA
Guanine Nucleotides
1 Citation (Scopus)

Neuroprotective effects of memantine via enhancement of autophagy

Hirano, K., Fujimaki, M., Sasazawa, Y., Yamaguchi, A., Ishikawa, K. I., Miyamoto, K., Souma, S., Furuya, N., Imamichi, Y., Yamada, D., Saya, H., Akamatsu, W., Saiki, S. & Hattori, N., 2019 Oct 8, In : Biochemical and Biophysical Research Communications. 518, 1, p. 161-170 10 p.

Research output: Contribution to journalArticle

Memantine
Autophagy
Neuroprotective Agents
Mitochondrial Degradation
N-Methyl-D-Aspartate Receptors
2 Citations (Scopus)

ROCK inhibition induces terminal adipocyte differentiation and suppresses tumorigenesis in chemoresistant osteosarcoma cells

Takahashi, N., Nobusue, H., Shimizu, T., Sugihara, E., Yamaguchi-Iwai, S., Onishi, N., Kunitomi, H., Kuroda, T. & Saya, H., 2019 Jun 15, In : Cancer Research. 79, 12, p. 3088-3099 12 p.

Research output: Contribution to journalArticle

Osteosarcoma
Adipocytes
Carcinogenesis
Stem Cells
Neoplastic Stem Cells
1 Citation (Scopus)
Open Access
Clinical Trials, Phase I
Amyotrophic Lateral Sclerosis
Labels
Placebos
Stem cells

Sulfasalazine could modulate the CD44v9-xCT system and enhance cisplatin-induced cytotoxic effects in metastatic bladder cancer

Ogihara, K., Kikuchi, E., Okazaki, S., Hagiwara, M., Takeda, T., Matsumoto, K., Kosaka, T., Mikami, S., Saya, H. & Oya, M., 2019 Apr 1, In : Cancer Science. 110, 4, p. 1431-1441 11 p.

Research output: Contribution to journalArticle

Open Access
Sulfasalazine
Urinary Bladder Neoplasms
Cisplatin
p38 Mitogen-Activated Protein Kinases
Muscles

The DNA topoisomerase II inhibitor amsacrine as a novel candidate adjuvant in a model of glaucoma filtration surgery

Yamamoto, K., Kokubun, T., Sato, K., Akaishi, T., Shimazaki, A., Nakamura, M., Shiga, Y., Tsuda, S., Omodaka, K., Saya, H. & Nakazawa, T., 2019 Dec 1, In : Scientific reports. 9, 1, 19288.

Research output: Contribution to journalArticle

Open Access
Amsacrine
Filtering Surgery
Topoisomerase II Inhibitors
Trabeculectomy
Glaucoma

Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy

Otsuki, Y., Yamasaki, J., Suina, K., Okazaki, S., Koike, N., Saya, H. & Nagano, O., 2019 Jan 1, (Accepted/In press) In : Cancer science.

Research output: Contribution to journalArticle

Open Access
Oxyfedrine
Vasodilator Agents
Aldehydes
Sulfasalazine
Neoplasms
1 Citation (Scopus)

Visualization of spatiotemporal dynamics of human glioma stem cell invasion

Tamura, R., Miyoshi, H., Sampetrean, O., Shinozaki, M., Morimoto, Y., Iwasawa, C., Fukaya, R., Mine, Y., Masuda, H., Maruyama, T., Narita, M., Saya, H., Yoshida, K., Okano, H. & Toda, M., 2019 May 6, In : Molecular brain. 12, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Glioma
Stem Cells
Glioblastoma
Axons
Time-Lapse Imaging
2018
5 Citations (Scopus)

An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment

Motohara, T., Masuda, K., Morotti, M., Zheng, Y., El-Sahhar, S., Chong, K. Y., Wietek, N., Alsaadi, A., Karaminejadranjbar, M., Hu, Z., Artibani, M., Gonzalez, L. S., Katabuchi, H., Saya, H. & Ahmed, A. A., 2018 Jan 1, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Omentum
Tropism
Tumor Microenvironment
Stromal Cells
3 Citations (Scopus)

CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake

Kobayashi, N., Okazaki, S., Sampetrean, O., Irie, J., Itoh, H. & Saya, H., 2018 Dec 1, In : Scientific Reports. 8, 1, 2785.

Research output: Contribution to journalArticle

Insulin
Amino Acids
Neutral Amino Acids
Antiporters
Amino Acid Transport Systems
4 Citations (Scopus)

Development of a functional thyroid model based on an organoid culture system

Saito, Y., Onishi, N., Takami, H., Seishima, R., Inoue, H., Hirata, Y., Kameyama, K., Tsuchihashi, K., Sugihara, E., Uchino, S., Ito, K., Kawakubo, H., Takeuchi, H., Kitagawa, Y., Saya, H. & Nagano, O., 2018 Mar 4, In : Biochemical and Biophysical Research Communications. 497, 2, p. 783-789 7 p.

Research output: Contribution to journalArticle

Organoids
Thyroglobulin
Iodides
Cell culture
Thyroid Gland
1 Citation (Scopus)

Dynamic changes in CD44v-positive cells after preoperative anti-HER2 therapy and its correlation with pathologic complete response in HER2-positive breast cancer

Yamauchi, T., Fernandez, J. R. E., Imamura, C., Yamauchi, H., Jinno, H., Takahashi, M., Kitagawa, Y., Nakamura, S., Lim, B., Krishnamurthy, S., Reuben, J. M., Liu, D., Tripathy, D., Chen, H., Takebe, N., Saya, H. & Ueno, N. T., 2018 Jan 1, In : Oncotarget. 9, 6, p. 6872-6882 11 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Epithelial-Mesenchymal Transition
Neoplastic Stem Cells
Therapeutics
Biomarkers
1 Citation (Scopus)

Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B-containing N-methyl-d-aspartate–sensitive glutamate receptor signaling

Suina, K., Tsuchihashi, K., Yamasaki, J., Kamenori, S., Shintani, S., Hirata, Y., Okazaki, S., Sampetrean, O., Baba, E., Akashi, K., Mitsuishi, Y., Takahashi, F., Takahashi, K., Saya, H. & Nagano, O., 2018 Jan 1, (Accepted/In press) In : Cancer Science.

Research output: Contribution to journalArticle

Glutamate Receptors
Epidermal Growth Factor Receptor
Glioma
Glutamic Acid
Epidermal Growth Factor
20 Citations (Scopus)

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival

Shiota, M., Naya, M., Yamamoto, T., Hishiki, T., Tani, T., Takahashi, H., Kubo, A., Koike, D., Itoh, M., Ohmura, M., Kabe, Y., Sugiura, Y., Hiraoka, N., Morikawa, T., Takubo, K., Suina, K., Nagashima, H., Sampetrean, O., Nagano, O., Saya, H. & 3 others, Yamazoe, S., Watanabe, H. & Suematsu, M., 2018 Dec 1, In : Nature Communications. 9, 1, 1561.

Research output: Contribution to journalArticle

Raman Spectrum Analysis
Oxidants
Gold
Raman spectroscopy
tumors
4 Citations (Scopus)

HER2 heterogeneity is associated with poor survival in HER2-positive breast cancer

Hosonaga, M., Arima, Y., Sampetrean, O., Komura, D., Koya, I., Sasaki, T., Sato, E., Okano, H., Kudo, J., Ishikawa, S., Saya, H. & Ishikawa, T., 2018 Aug 1, In : International Journal of Molecular Sciences. 19, 8, 2158.

Research output: Contribution to journalArticle

breast
cancer
Breast Neoplasms
mice
RNA Sequence Analysis
4 Citations (Scopus)

Inhibiting xCT improves 5-fluorouracil resistance of gastric cancer induced by CD44 variant 9 expression

Miyoshi, S., Tsugawa, H., Matsuzaki, J., Hirata, K., Mori, H., Saya, H., Kanai, T. & Suzuki, H., 2018 Nov 1, In : Anticancer Research. 38, 11, p. 6163-6170 8 p.

Research output: Contribution to journalArticle

Fluorouracil
Stomach Neoplasms
Neoplastic Stem Cells
Antiporters
Drug Therapy
5 Citations (Scopus)

Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model

Shibao, S., Minami, N., Koike, N., Fukui, N., Yoshida, K., Saya, H. & Sampetrean, O., 2018 Feb 19, In : Neuro-Oncology. 20, 3, p. 343-354 12 p.

Research output: Contribution to journalArticle

Glioblastoma
Glioma
Stem Cells
Lactic Acid
Oxidative Phosphorylation
20 Citations (Scopus)

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

Fujimori, K., Ishikawa, M., Otomo, A., Atsuta, N., Nakamura, R., Akiyama, T., Hadano, S., Aoki, M., Saya, H., Sobue, G. & Okano, H., 2018 Jan 1, (Accepted/In press) In : Nature Medicine.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Amyotrophic Lateral Sclerosis
Motor Neurons
Stem cells
Neurons
3 Citations (Scopus)

Periostin antisense oligonucleotide suppresses bleomycin-induced formation of a lung premetastatic niche for melanoma

Semba, T., Sugihara, E., Kamoshita, N., Ueno, S., Fukuda, K., Yoshino, M., Takao, K., Yoshikawa, K., Izuhara, K., Arima, Y., Suzuki, M. & Saya, H., 2018 Jan 1, (Accepted/In press) In : Cancer Science.

Research output: Contribution to journalArticle

Antisense Oligonucleotides
Bleomycin
Melanoma
Lung
Neoplasm Metastasis

Recurrent Spindle Cell Carcinoma Shows Features of Mesenchymal Stem Cells

Ouchi, T., Morikawa, S., Shibata, S., Takahashi, M., Yoshikawa, M., Soma, T., Miyashita, H., Muraoka, W., Kameyama, K., Kawana, H., Arima, Y., Saya, H., Okano, H., Nakagawa, T. & Asoda, S., 2018 Feb 1, (Accepted/In press) In : Journal of Dental Research.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Carcinoma
Cell Death
Platelet-Derived Growth Factor Receptors
Drug Therapy
6 Citations (Scopus)

Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells

Okazaki, S., Shintani, S., Hirata, Y., Suina, K., Semba, T., Yamasaki, J., Umene, K., Ishikawa, M., Saya, H. & Nagano, O., 2018 Sep 1, In : Oncotarget. 9, 73, p. 33832-33843 12 p.

Research output: Contribution to journalArticle

Sulfasalazine
Glutathione
Neoplasms
Antiporters
Aldehyde Dehydrogenase
1 Citation (Scopus)

Therapeutic potential of tranilast for the treatment of chronic graft-versus-host disease in mice

Mukai, S., Ogawa, Y., Saya, H., Kawakami, Y. & Tsubota, K., 2018 Oct 1, In : PLoS One. 13, 10, e0203742.

Research output: Contribution to journalArticle

Graft vs Host Disease
Grafts
therapeutics
mice
bone marrow transplant
4 Citations (Scopus)

Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells

Harigai, R., Sakai, S., Nobusue, H., Hirose, C., Sampetrean, O., Minami, N., Hata, Y., Kasama, T., Hirose, T., Takenouchi, T., Kosaki, K., Kishi, K., Saya, H. & Arima, Y., 2018 Dec 1, In : Scientific Reports. 8, 1, 6069.

Research output: Contribution to journalArticle

Neurofibromin 1
Neurofibromatosis 1
Epithelial-Mesenchymal Transition
Neurofibroma
Gene Expression
12 Citations (Scopus)

T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease

Tabata, Y., Imaizumi, Y., Sugawara, M., Andoh-Noda, T., Banno, S., Chai, M. C., Sone, T., Yamazaki, K., Ito, M., Tsukahara, K., Saya, H., Hattori, N., Kohyama, J. & Okano, H., 2018 Nov 13, In : Stem Cell Reports. 11, 5, p. 1171-1184 14 p.

Research output: Contribution to journalArticle

T-Type Calcium Channels
Dopaminergic Neurons
Neurons
Parkinson Disease
Rotenone
4 Citations (Scopus)
Cisplatin
Protein Isoforms
Population
Neoplasms
Glutathione
2017
36 Citations (Scopus)

Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells

Ishimoto, T., Miyake, K., Nandi, T., Yashiro, M., Onishi, N., Huang, K. K., Lin, S. J., Kalpana, R., Tay, S. T., Suzuki, Y., Cho, B. C., Kuroda, D., Arima, K., Izumi, D., Iwatsuki, M., Baba, Y., Oki, E., Watanabe, M., Saya, H., Hirakawa, K. & 2 others, Baba, H. & Tan, P., 2017 Jul 1, In : Gastroenterology. 153, 1, p. 191-204.e16

Research output: Contribution to journalArticle

Transforming Growth Factor beta
Stomach Neoplasms
Fibroblasts
Nude Mice
Extracellular Matrix
7 Citations (Scopus)

Blocking COX-2 induces apoptosis and inhibits cell proliferation via the Akt/survivin- and Akt/ID3 pathway in low-grade-glioma

Sato, A., Mizobuchi, Y., Nakajima, K., Shono, K., Fujihara, T., Kageji, T., Kitazato, K., Matsuzaki, K., Mure, H., Kuwayama, K., Sumi, A., Saya, H., Sampetrean, O. & Nagahirao, S., 2017 Apr 1, In : Journal of Neuro-Oncology. 132, 2, p. 231-238 8 p.

Research output: Contribution to journalArticle

Celecoxib
Glioma
Cell Proliferation
Apoptosis
Cyclooxygenase 2 Inhibitors
4 Citations (Scopus)

Calcitriol exerts an anti-tumor effect in osteosarcoma by inducing the endoplasmic reticulum stress response

Shimizu, T., Kamel, W. A., Yamaguchi-Iwai, S., Fukuchi, Y., Muto, A. & Saya, H., 2017 Sep 1, In : Cancer Science. 108, 9, p. 1793-1802 10 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Calcitriol
Osteosarcoma
Neoplasms
Therapeutics
4 Citations (Scopus)

CD44 variant–dependent regulation of redox balance in EGFR mutation–positive non–small cell lung cancer: A target for treatment

Kawano, Y., Iwama, E., Tsuchihashi, K., Shibahara, D., Harada, T., Tanaka, K., Nagano, O., Saya, H., Nakanishi, Y. & Okamoto, I., 2017 Nov 1, In : Lung Cancer. 113, p. 72-78 7 p.

Research output: Contribution to journalArticle

erbB-1 Genes
Non-Small Cell Lung Carcinoma
Oxidation-Reduction
Reactive Oxygen Species
Cisplatin
3 Citations (Scopus)

Convection-enhanced delivery of sulfasalazine prolongs survival in a glioma stem cell brain tumor model

Haryu, S., Saito, R., Jia, W., Shoji, T., Mano, Y., Sato, A., Kanamori, M., Sonoda, Y., Sampetrean, O., Saya, H. & Tominaga, T., 2017 Sep 19, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Sulfasalazine
Convection
Brain Neoplasms
Glioma
Stem Cells
12 Citations (Scopus)

cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells

Miyano, K., Cabral, H., Miura, Y., Matsumoto, Y., Mochida, Y., Kinoh, H., Iwata, C., Nagano, O., Saya, H., Nishiyama, N., Kataoka, K. & Yamasoba, T., 2017 Sep 10, In : Journal of Controlled Release. 261, p. 275-286 12 p.

Research output: Contribution to journalArticle

Nanomedicine
Neoplastic Stem Cells
Cisplatin
Neoplasms
Ligands
2 Citations (Scopus)

Development of Highly Selective Fluorescent Probe Enabling Flow-Cytometric Isolation of ALDH3A1-Positive Viable Cells

Yagishita, A., Ueno, T., Esumi, H., Saya, H., Kaneko, K., Tsuchihara, K. & Urano, Y., 2017 Feb 15, In : Bioconjugate Chemistry. 28, 2, p. 302-306 5 p.

Research output: Contribution to journalArticle

Aldehydes
Fluorescent Dyes
Cells
Aldehyde Dehydrogenase
Fluorescence microscopy
7 Citations (Scopus)

Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis

Jeong, S., Choi, E., Petersen, C. P., Roland, J. T., Federico, A., Ippolito, R., D'Armiento, F. P., Nardone, G., Nagano, O., Saya, H., Romano, M. & Goldenring, J. R., 2017, In : United European Gastroenterology Journal. 5, 1, p. 37-44 8 p.

Research output: Contribution to journalArticle

Atrophic Gastritis
Gastritis
Adenocarcinoma
Metaplasia
Phenotype
15 Citations (Scopus)

Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality

Kitagawa, M., Liao, P. J., Lee, K. H., Wong, J., Shang, S. C., Minami, N., Sampetrean, O., Saya, H., Lingyun, D., Prabhu, N., Diam, G. K., Sobota, R., Larsson, A., Nordlund, P., McCormick, F., Ghosh, S., Epstein, D. M., Dymock, B. W. & Lee, S. H., 2017 Dec 1, In : Nature Communications. 8, 1, 2200.

Research output: Contribution to journalArticle

lethality
Phosphatidylinositol 3-Kinases
lipids
Phosphotransferases
cancer
15 Citations (Scopus)
Microfluidics
Endothelial cells
Coculture Techniques
Glioma
Endothelium

Establishment of pten knockout medaka with transcription activator–like effector nucleases (TALENs) as a model of PTEN deficiency disease

Matsuzaki, Y., Sakuma, T., Yamamoto, T. & Saya, H., 2017 Oct 1, In : PLoS One. 12, 10, e0186878.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Oryzias
Deficiency Diseases
deficiency diseases
nucleases
4 Citations (Scopus)

Functional analysis of the DEPDC1 oncoantigen in malignant glioma and brain tumor initiating cells

Kikuchi, R., Sampetrean, O., Saya, H., Yoshida, K. & Toda, M., 2017 May 29, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-11 11 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Brain Neoplasms
Glioma
NF-kappa B
1-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride
3 Citations (Scopus)

FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia

Ishizawa, J., Sugihara, E., Kuninaka, S., Mogushi, K., Kojima, K., Benton, C. B., Zhao, R., Chachad, D., Hashimoto, N., Jacamo, R. O., Qiu, Y., Yoo, S. Y., Okamoto, S., Andreeff, M., Kornblau, S. M. & Saya, H., 2017 Apr 6, In : Blood. 129, 14, p. 1958-1968 11 p.

Research output: Contribution to journalArticle

B-Cell Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
DNA Damage
B-Lymphocytes
Cells
4 Citations (Scopus)

Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression

Kasai, S., Furuichi, Y., Ando, N., Kagami, K., Abe, M., Nakane, T., Goi, K., Inukai, T., Saitoh, S., Ohno, S., Okazaki, S., Nagano, O., Saya, H. & Sugita, K., 2017 Jun 1, In : Cell death & disease. 8, 6, p. e2857

Research output: Contribution to journalArticle

B-Cell Leukemia
B-Lymphoid Precursor Cells
Hyaluronic Acid
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
7 Citations (Scopus)

Organotypic brain explant culture as a drug evaluation system for malignant brain tumors

Minami, N., Maeda, Y., Shibao, S., Arima, Y., Ohka, F., Kondo, Y., Maruyama, K., Kusuhara, M., Sasayama, T., Kohmura, E., Saya, H. & Sampetrean, O., 2017 Nov 1, In : Cancer Medicine. 6, 11, p. 2635-2645 11 p.

Research output: Contribution to journalArticle

Drug Evaluation
Brain Neoplasms
temozolomide
Brain
Glioma
13 Citations (Scopus)

Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407)

Shitara, K., Doi, T., Nagano, O., Fukutani, M., Hasegawa, H., Nomura, S., Sato, A., Kuwata, T., Asai, K., Einaga, Y., Tsuchihashi, K., Suina, K., Maeda, Y., Saya, H. & Ohtsu, A., 2017 May 2, (Accepted/In press) In : Gastric Cancer. p. 1-6 6 p.

Research output: Contribution to journalArticle

Sulfasalazine
Cisplatin
Stomach Neoplasms
Amino Acid Transport System X-AG
Cystine
8 Citations (Scopus)

Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non-small-cell lung cancer

Otsubo, K., Nosaki, K., Imamura, C., Ogata, H., Fujita, A., Sakata, S., Hirai, F., Toyokawa, G., Iwama, E., Harada, T., Seto, T., Takenoyama, M., Ozeki, T., Mushiroda, T., Inada, M., Kishimoto, J., Tsuchihashi, K., Suina, K., Nagano, O., Saya, H. & 2 others, Nakanishi, Y. & Okamoto, I., 2017, (Accepted/In press) In : Cancer Science.

Research output: Contribution to journalArticle

Pemetrexed
Sulfasalazine
Non-Small Cell Lung Carcinoma
Cisplatin
Neoplastic Stem Cells
7 Citations (Scopus)

Reducing inflammatory cytokine production from renal collecting duct cells by inhibiting GATA2 ameliorates acute kidney injury

Yu, L., Moriguchi, T., Kaneko, H., Hayashi, M., Hasegawa, A., Nezu, M., Saya, H., Yamamoto, M. & Shimizu, R., 2017 Nov 1, In : Molecular and Cellular Biology. 37, 22, e00211-17.

Research output: Contribution to journalArticle

Acute Kidney Injury
Cytokines
Kidney
Reperfusion Injury
Collecting Kidney Tubules
7 Citations (Scopus)

Rheostatic CD44 isoform expression and its association with oxidative stress in human malignant mesothelioma

Chew, S. H., Okazaki, Y., Akatsuka, S., Wang, S., Jiang, L., Ohara, Y., Ito, F., Saya, H., Sekido, Y. & Toyokuni, S., 2017 May 1, In : Free Radical Biology and Medicine. 106, p. 91-99 9 p.

Research output: Contribution to journalArticle

Oxidative stress
Protein Isoforms
Oxidative Stress
Association reactions
Cells
11 Citations (Scopus)

RNA Sequencing Analysis Reveals Interactions between Breast Cancer or Melanoma Cells and the Tissue Microenvironment during Brain Metastasis

Sato, R., Nakano, T., Hosonaga, M., Sampetrean, O., Harigai, R., Sasaki, T., Koya, I., Okano, H., Kudo, J., Saya, H. & Arima, Y., 2017, In : BioMed Research International. 2017, 8032910.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Cellular Microenvironment
Melanoma
Brain
RNA