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Research Output 1995 2019

  • 1962 Citations
  • 18 h-Index
  • 81 Article
  • 6 Review article
  • 1 Conference contribution
2019
1 Citation (Scopus)

Association Between CD133, CD44, and Nestin Expression and Prognostic Factors in High-Grade Meningioma

Kamamoto, D., Saga, I., Ohara, K., Yoshida, K. & Sasaki, H., 2019 Jan 1, (Accepted/In press) In : World Neurosurgery.

Research output: Contribution to journalArticle

Nestin
Meningioma
Neoplastic Stem Cells
Disease-Free Survival
Recurrence

Clinical, histopathological, and molecular analyses of IDH-wild-type WHO grade II–III gliomas to establish genetic predictors of poor prognosis

Kuwahara, K., Ohba, S., Nakae, S., Hattori, N., Pareira, E. S., Yamada, S., Sasaki, H., Abe, M., Hasegawa, M. & Hirose, Y., 2019 Jan 1, In : Brain tumor pathology.

Research output: Contribution to journalArticle

Isocitrate Dehydrogenase
Glioma
Telomerase
Mutation
Chromosomes, Human, Pair 7
1 Citation (Scopus)

c-Met Expression Is a Useful Marker for Prognosis Prediction in IDH-Mutant Lower-Grade Gliomas and IDH-Wildtype Glioblastomas

Ohba, S., Yamada, Y., Murayama, K., Sandika, E., Sasaki, H., Yamada, S., Abe, M., Hasegawa, M. & Hirose, Y., 2019 Jan 1, In : World neurosurgery.

Research output: Contribution to journalArticle

Astrocytoma
Glioblastoma
Glioma
Oligodendroglioma
Neoplasms
Glioma
Software
Magnetic Resonance Imaging
Isocitrate Dehydrogenase
Methyltransferases
2 Citations (Scopus)

Predictive markers for MGMT promoter methylation in glioblastomas

Kanazawa, T., Minami, Y., Jinzaki, M., Toda, M., Yoshida, K. & Sasaki, H., 2019 Jan 1, (Accepted/In press) In : Neurosurgical Review.

Research output: Contribution to journalArticle

Methyltransferases
Glioblastoma
Genetic Markers
Methylation
DNA
1 Citation (Scopus)

The role of vascular endothelial growth factor in the hypoxic and immunosuppressive tumor microenvironment: perspectives for therapeutic implications

Tamura, R., Tanaka, T., Akasaki, Y., Murayama, Y., Yoshida, K. & Sasaki, H., 2019 Nov 11, In : Medical oncology (Northwood, London, England). 37, 1, 1 p.

Research output: Contribution to journalReview article

Open Access
Tumor Microenvironment
Immunosuppressive Agents
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factor Receptor
Neoplasms

Tumor immune microenvironment is associated with the growth of intracranial germinomas

Nishimoto, M., Ohara, K., Kamamoto, D., Tamura, R., Miwa, T., Yoshida, K. & Sasaki, H., 2019 Jan 1, (Accepted/In press) In : Journal of Neuro-Oncology.

Research output: Contribution to journalArticle

Germinoma
Tumor Microenvironment
CD274 Antigen
Growth
CD8-Positive T-Lymphocytes
2018
6 Citations (Scopus)

A pilot study of peptide vaccines for VEGF receptor 1 and 2 in patients with recurrent/progressive high grade glioma

Shibao, S., Ueda, R., Saito, K., Kikuchi, R., Nagashima, H., Kojima, A., Kagami, H., Pareira, E. S., Sasaki, H., Noji, S., Kawakami, Y., Yoshida, K. & Toda, M., 2018 Apr 20, In : Oncotarget. 9, 30, p. 21569-21579 11 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factor Receptor-2
Subunit Vaccines
Glioma
Vascular Endothelial Growth Factor Receptor
2 Citations (Scopus)

Association between programmed cell death ligand-1 expression and extracranial metastasis in intracranial solitary fibrous tumor/hemangiopericytoma

Kamamoto, D., Ohara, K., Kitamura, Y., Yoshida, K., Kawakami, Y. & Sasaki, H., 2018 Apr 19, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Solitary Fibrous Tumors
Hemangiopericytoma
Cell Death
Neoplasm Metastasis
Ligands
2 Citations (Scopus)

Difference in Immunosuppressive Cells Between Peritumoral Area and Tumor Core in Glioblastoma

Tamura, R., Ohara, K., Sasaki, H., Morimoto, Y., Kosugi, K., Yoshida, K. & Toda, M., 2018 Jan 1, (Accepted/In press) In : World Neurosurgery.

Research output: Contribution to journalArticle

Glioblastoma
Immunosuppressive Agents
Vascular Endothelial Growth Factor A
Brain
Hypoxia-Inducible Factor 1
13 Citations (Scopus)

Dual role of macrophage in tumor immunity

Tamura, R., Tanaka, T., Yamamoto, Y., Akasaki, Y. & Sasaki, H., 2018 Aug 1, In : Immunotherapy. 10, 10, p. 899-909 11 p.

Research output: Contribution to journalReview article

Immunity
Macrophages
Neoplasms
Cytokines
Immunotherapy
15 Citations (Scopus)

Effects of surgery with salvage stereotactic radiosurgery versus surgery with whole-brain radiation therapy in patients with one to four brain metastases (JCOG0504): A Phase III, noninferiority, randomized controlled trial

Kayama, T., Sato, S., Sakurada, K., Mizusawa, J., Nishikawa, R., Narita, Y., Sumi, M., Miyakita, Y., Kumabe, T., Sonoda, Y., Arakawa, Y., Miyamoto, S., Beppu, T., Sugiyama, K., Nakamura, H., Nagane, M., Nakasu, Y., Hashimoto, N., Terasaki, M., Matsumura, A. & 30 others, Ishikawa, E., Wakabayashi, T., Iwadate, Y., Ohue, S., Kobayashi, H., Kinoshita, M., Asano, K., Mukasa, A., Tanaka, K., Asai, A., Nakamura, H., Abe, T., Muragaki, Y., Iwasaki, K., Aoki, T., Watanabe, T., Sasaki, H., Izumoto, S., Mizoguchi, M., Matsuo, T., Takeshima, H., Hayashi, M., Jokura, H., Mizowaki, T., Shimizu, E., Shirato, H., Tago, M., Katayama, H., Fukuda, H. & Shibui, S., 2018 Nov 20, In : Journal of Clinical Oncology. 36, 33, p. 3282-3289 8 p.

Research output: Contribution to journalArticle

Radiosurgery
Radiotherapy
Randomized Controlled Trials
Neoplasm Metastasis
Brain

Identification method of environmental stiffness using haptic forceps for brain surgery

Aoki, M., Shimon, T., Matsunaga, T., Mizoguchi, T., Shibao, S., Sasaki, H. & Ohnishi, K., 2018 Aug 30, AIM 2018 - IEEE/ASME International Conference on Advanced Intelligent Mechatronics. Institute of Electrical and Electronics Engineers Inc., Vol. 2018-July. p. 207-212 6 p. 8452259

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Surgery
Brain
Stiffness
Tissue
Neurosurgery

II. Treatment of glioblastoma with alternating electric fields

Kamamoto, D. & Sasaki, H., 2018 Jun 1, In : Japanese Journal of Cancer and Chemotherapy. 45, 6, p. 927-932 6 p.

Research output: Contribution to journalArticle

Glioblastoma
2 Citations (Scopus)

Imaging scoring systems for preoperative molecular diagnoses of lower-grade gliomas

Kanazawa, T., Fujiwara, H., Takahashi, H., Nishiyama, Y., Hirose, Y., Tanaka, S., Yoshida, K. & Sasaki, H., 2018 Apr 26, (Accepted/In press) In : Neurosurgical Review. p. 1-9 9 p.

Research output: Contribution to journalArticle

Glioma
Methylation
Neoplasms
Mutation
Therapeutics

JCOG0911 INTEGRA study: a randomized screening phase II trial of interferonβ plus temozolomide in comparison with temozolomide alone for newly diagnosed glioblastoma

Members of Japan Clinical Oncology Group Brain Tumor Study Group (JCOG-BTSG), 2018 Jul 1, In : Journal of Neuro-Oncology. 138, 3, p. 627-636 10 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Interferons
Radiotherapy
Maintenance
4 Citations (Scopus)

Persistent restoration to the immunosupportive tumor microenvironment in glioblastoma by bevacizumab

Tamura, R., Tanaka, T., Ohara, K., Miyake, K., Morimoto, Y., Yamamoto, Y., Kanai, R., Akasaki, Y., Murayama, Y., Tamiya, T., Yoshida, K. & Sasaki, H., 2018 Jan 1, (Accepted/In press) In : Cancer Science.

Research output: Contribution to journalArticle

Tumor Microenvironment
Glioblastoma
Neoplasms
Bevacizumab
CD274 Antigen
5 Citations (Scopus)
Solitary Fibrous Tumors
Hemangiopericytoma
Meningioma
Magnetic Resonance Imaging
Entropy
3 Citations (Scopus)

Pros and cons of using ORBEYE™ for microneurosurgery

Takahashi, S., Toda, M., Nishimoto, M., Ishihara, E., Miwa, T., Akiyama, T., Horiguchi, T., Sasaki, H. & Yoshida, K., 2018 Nov 1, In : Clinical Neurology and Neurosurgery. 174, p. 57-62 6 p.

Research output: Contribution to journalArticle

Crystalline Lens
Equipment and Supplies
Neurosurgeons
Surveys and Questionnaires
Glioblastoma
Thyroid Neoplasms
Magnetic Resonance Imaging
lenvatinib
2017
1 Citation (Scopus)
Hematoma, Subdural, Acute
Chondrosarcoma
Skull
Hemorrhage
Neoplasm Metastasis

A case of glioblastoma resected immediately after administering bevacizumab: consideration on histopathological findings and safety of surgery

Tokuda, Y., Tamura, R., Ohara, K., Yoshida, K. & Sasaki, H., 2017 Apr 1, In : Brain Tumor Pathology. 34, 2, p. 98-102 5 p.

Research output: Contribution to journalArticle

Glioblastoma
Safety
temozolomide
Neoplasms
Thrombosis
30 Citations (Scopus)

Bevacizumab for malignant gliomas: current indications, mechanisms of action and resistance, and markers of response

Tamura, R., Tanaka, T., Miyake, K., Yoshida, K. & Sasaki, H., 2017 Apr 6, (Accepted/In press) In : Brain Tumor Pathology. p. 1-16 16 p.

Research output: Contribution to journalArticle

Glioma
Glioblastoma
Vascular Endothelial Growth Factor A
Biomarkers
Stem Cell Niche
10 Citations (Scopus)

Clinical and Molecular Prognostic Factors for Long-Term Survival of Patients with Glioblastomas in Single-Institutional Consecutive Cohort

Nakagawa, Y., Sasaki, H., Ohara, K., Ezaki, T., Toda, M., Oohira, T., Kawase, T. & Yoshida, K., 2017 Oct 1, In : World Neurosurgery. 106, p. 165-173 9 p.

Research output: Contribution to journalArticle

Glioblastoma
Survivors
Survival
Lateral Ventricles
Karnofsky Performance Status
5 Citations (Scopus)

Comprehensive genetic characterization of rosette-forming glioneuronal tumors: Independent component analysis by tissue microdissection

Kitamura, Y., Komori, T., Shibuya, M., Ohara, K., Saito, Y., Hayashi, S., Sasaki, A., Nakagawa, E., Tomio, R., Kakita, A., Nakatsukasa, M., Yoshida, K. & Sasaki, H., 2017, (Accepted/In press) In : Brain Pathology.

Research output: Contribution to journalArticle

Microdissection
Neuroglia
Astrocytoma
Neoplasms
Mutation
4 Citations (Scopus)

Genetic aberrations and molecular biology of skull base chordoma and chondrosarcoma

Kitamura, Y., Sasaki, H. & Yoshida, K., 2017 Apr 1, In : Brain Tumor Pathology. 34, 2, p. 78-90 13 p.

Research output: Contribution to journalArticle

Chordoma
Chondrosarcoma
Skull Base
Molecular Biology
Neoplasms
6 Citations (Scopus)

Histopathological vascular investigation of the peritumoral brain zone of glioblastomas

Tamura, R., Ohara, K., Sasaki, H., Morimoto, Y., Yoshida, K. & Toda, M., 2017 Nov 29, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Glioblastoma
Blood Vessels
Brain Neoplasms
Nestin
Vascular Endothelial Growth Factor Receptor
4 Citations (Scopus)

"Paradoxical" findings of tumor vascularity and oxygenation in recurrent glioblastomas refractory to bevacizumab

Yamamoto, Y., Tamura, R., Tanaka, T., Ohara, K., Tokuda, Y., Miyake, K., Takei, J., Akasaki, Y., Yoshida, K., Murayama, Y. & Sasaki, H., 2017 Jan 1, In : Oncotarget. 8, 61, p. 103890-103899 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Neoplasms
Microvessels
Nestin
Bevacizumab
5 Citations (Scopus)

Prediction of genetic subgroups in adult supra tentorial gliomas by pre- and intraoperative parameters

Nakae, S., Murayama, K., Sasaki, H., Kumon, M., Nishiyama, Y., Ohba, S., Adachi, K., Nagahisa, S., Hayashi, T., Inamasu, J., Abe, M., Hasegawa, M. & Hirose, Y., 2017 Jan 1, In : Journal of Neuro-Oncology. 131, 2, p. 403-412 10 p.

Research output: Contribution to journalArticle

Glioma
Aminolevulinic Acid
Magnetic Resonance Spectroscopy
Inositol
Choline

Remote intracranial recurrence of IDH mutant gliomas is associated with TP53 mutations and an 8q gain

Nakae, S., Kato, T., Murayama, K., Sasaki, H., Abe, M., Kumon, M., Kumai, T., Yamashiro, K., Inamasu, J., Hasegawa, M., Kurahashi, H. & Hirose, Y., 2017 Oct 17, In : Oncotarget. 8, 49, p. 84729-84742 14 p.

Research output: Contribution to journalArticle

Glioma
Recurrence
Mutation
Astrocytoma
Neoplasms
2 Citations (Scopus)
Glioma
Central Nervous System Neoplasms
Clinical Trials
Oligodendroglioma
Astrocytoma
3 Citations (Scopus)

Unusual Magnetic Resonance Imaging Findings of a Glioblastoma Arising During Treatment with Lenvatinib for Thyroid Cancer

Arai, N., Sasaki, H., Tamura, R., Ohara, K. & Yoshida, K., 2017, (Accepted/In press) In : World Neurosurgery.

Research output: Contribution to journalArticle

Glioblastoma
Thyroid Neoplasms
Magnetic Resonance Imaging
Protein-Tyrosine Kinases
Edema
2016
3 Citations (Scopus)

A case of papillary tumor of the pineal region with a long clinical history: molecular characterization and therapeutic consideration with review of the literature

Kamamoto, D., Sasaki, H., Ohara, K., Mizutani, K. & Yoshida, K., 2016 Jul 29, (Accepted/In press) In : Brain Tumor Pathology. p. 1-5 5 p.

Research output: Contribution to journalArticle

Local Neoplasm Recurrences
Antineoplastic Combined Chemotherapy Protocols
Pinealoma
Neurosurgical Procedures
Intensity-Modulated Radiotherapy
4 Citations (Scopus)
Sarcoma
Radiation
Hemorrhage
Neoplasms
Radiotherapy
23 Citations (Scopus)

Histopathological investigation of glioblastomas resected under bevacizumab treatment

Tamura, R., Tanaka, T., Miyake, K., Tabei, Y., Ohara, K., Sampetrean, O., Kono, M., Mizutani, K., Yamamoto, Y., Murayama, Y., Tamiya, T., Yoshida, K. & Sasaki, H., 2016 Aug 1, In : Oncotarget. 7, 32, p. 52423-52435 13 p.

Research output: Contribution to journalArticle

Glioblastoma
Nestin
Microvessels
Vascular Endothelial Growth Factor Receptor
Neoplasms

Molecular Classification and Personalized Treatment of Gliomas

Sasaki, H. & Yoshida, K., 2016 Mar 1, In : No shinkei geka. Neurological surgery. 44, 3, p. 185-201 17 p.

Research output: Contribution to journalReview article

Chromosome Deletion
Precision Medicine
DNA Methylation
Genetic Promoter Regions
Brain Neoplasms
4 Citations (Scopus)
Glioma
Chromosomes
Methyltransferases
Methylation
Survival
15 Citations (Scopus)

Revised WHO Classification of tumours of the central nervous system: Summary of the revision and perspective

Komori, T., Sasaki, H. & Yoshida, K., 2016 Aug 1, In : Neurological Surgery. 44, 8, p. 625-635 11 p.

Research output: Contribution to journalReview article

Central Nervous System Neoplasms
Neoplasm Grading
Central Nervous System
Mutation
10 Citations (Scopus)

World Health Organization grade II–III astrocytomas consist of genetically distinct tumor lineages

Hattori, N., Hirose, Y., Sasaki, H., Nakae, S., Hayashi, S., Ohba, S., Adachi, K., Hayashi, T., Nishiyama, Y., Hasegawa, M. & Abe, M., 2016 Aug 1, In : Cancer Science. 107, 8, p. 1159-1164 6 p.

Research output: Contribution to journalArticle

Isocitrate Dehydrogenase
Astrocytoma
Neoplasms
Chromosomes, Human, Pair 7
Glioma
2015
7 Citations (Scopus)

Genetic characterization of skull base chondrosarcomas

Kanamori, H., Kitamura, Y., Kimura, T., Yoshida, K. & Sasaki, H., 2015 Oct 1, In : Journal of Neurosurgery. 123, 4, p. 1036-1041 6 p.

Research output: Contribution to journalArticle

Chondrosarcoma
Skull Base
Chordoma
Comparative Genomic Hybridization
Mutation
8 Citations (Scopus)

Molecular-genetic and clinical characteristics of gliomas with astrocytic appearance and total 1p19q loss in a single institutional consecutive cohort

Hayashi, S., Sasaki, H., Kimura, T., Abe, T., Nakamura, T., Kitamura, Y., Miwa, T., Kameyama, K., Hirose, Y. & Yoshida, K., 2015, In : Oncotarget. 6, 18, p. 15871-15881 11 p.

Research output: Contribution to journalArticle

Astrocytoma
Molecular Biology
Glioma
Survival
Chromosomes, Human, Pair 7
6 Citations (Scopus)

PCR-based simple subgrouping is validated for classification of gliomas and defines negative prognostic copy number aberrations in IDH mutant gliomas

Nakae, S., Sasaki, H., Hayashi, S., Hattori, N., Kumon, M., Nishiyama, Y., Adachi, K., Nagahisa, S., Hayashi, T., Inamasu, J., Abe, M., Hasegawa, M. & Hirose, Y., 2015 Nov 1, In : PLoS One. 10, 11, e0142750.

Research output: Contribution to journalArticle

Polymerase chain reaction
Aberrations
Glioma
Isocitrate Dehydrogenase
polymerase chain reaction
10 Citations (Scopus)

Upfront chemotherapy and subsequent resection for molecularly defined gliomas

Sasaki, H., Hirose, Y., Yazaki, T., Kitamura, Y., Katayama, M., Kimura, T., Fujiwara, H., Toda, M., Oohira, T. & Yoshida, K., 2015 Aug 23, In : Journal of Neuro-Oncology. 124, 1, p. 127-135 9 p.

Research output: Contribution to journalArticle

Glioma
Drug Therapy
Neoplasms
Tumor Burden
Methylation
2014
8 Citations (Scopus)

A case of radiologically multicentric but genetically identical multiple glioblastomas

Akimoto, J., Sasaki, H., Haraoka, R., Nakajima, N., Fukami, S. & Kohno, M., 2014, In : Brain Tumor Pathology. 31, 2, p. 113-117 5 p.

Research output: Contribution to journalArticle

Glioblastoma
Glioma
Cerebrum
Neoplasms
Mutation

Central nervous system tumor: Glioma. I. neoadjuvant therapy in the treatment of brain tumors

Sasaki, H., Nishiyama, Y. & Yoshida, K., 2014, In : Japanese Journal of Cancer and Chemotherapy. 41, 6, p. 709-712 4 p.

Research output: Contribution to journalArticle

Central Nervous System Neoplasms
Neoadjuvant Therapy
Brain Neoplasms
Glioma
Therapeutics
6 Citations (Scopus)

Radiological features of supratentorial gliomas are associated with their genetic aberrations

Nishiyama, Y., Sasaki, H., Nagahisa, S., Adachi, K., Hayashi, T., Yoshida, K., Kawase, T., Hattori, N., Murayama, K., Abe, M., Hasegawa, M. & Hirose, Y., 2014, In : Neurosurgical Review. 37, 2, p. 291-300 10 p.

Research output: Contribution to journalArticle

Supratentorial Neoplasms
Oligodendroglioma
Genetic Testing
Genetic Predisposition to Disease
Glioma

Recent advance and updates in chemotherapy for Glioma

Sasaki, H., 2014, In : Japanese Journal of Neurosurgery. 23, 7, p. 547-558 12 p.

Research output: Contribution to journalArticle

Glioma
Glioblastoma
Drug Therapy
temozolomide
Oligodendroglioma
14 Citations (Scopus)
Brain Abscess
Neural Tube Defects
Cysts
Hemorrhage
Headache
2013
8 Citations (Scopus)

Immunohistochemical and molecular genetics study of a granular cell astrocytoma: A case report of malignant transformation to a glioblastoma

Ishii, T., Mizukawa, K., Sasayama, T., Sasaki, H., Hayashi, S., Nakamizo, S., Tanaka, H., Tanaka, K., Hara, S., Hirai, C., Itoh, T. & Kohmura, E., 2013 Jun, In : Neuropathology. 33, 3, p. 299-305 7 p.

Research output: Contribution to journalArticle

Astrocytoma
Glioblastoma
Molecular Biology
Neoplasms
Parietal Lobe
1 Citation (Scopus)

Infratentorial low-grade oligoastrocytoma with aggressive clinical behavior in an adult: A case report with genetic characterization

Sano, K., Toda, M., Sasaki, H., Kitamura, Y., Mikami, S., Hirato, J., Inoue, S., Kawase, T. & Yoshida, K., 2013 Apr, In : Brain Tumor Pathology. 30, 2, p. 99-103 5 p.

Research output: Contribution to journalArticle

temozolomide
Glioma
Cerebellar Neoplasms
Isocitrate Dehydrogenase
Chromosomes, Human, Pair 7