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Research Output 2000 2019

  • 1448 Citations
  • 18 h-Index
  • 62 Article
2019
1 Citation (Scopus)

A phase II trial of induction of erlotinib followed by cytotoxic chemotherapy for EGFR mutation-positive non-squamous non-small cell lung cancer patients

Tani, T., Naoki, K., Yasuda, H., Arai, D., Ishioka, K., Ohgino, K., Yoda, S., Nakayama, S., Satomi, R., Terai, H., Ikemura, S., Sato, T. & Soejima, K., 2019 Jan 1, (Accepted/In press) In : Cancer Chemotherapy and Pharmacology.

Research output: Contribution to journalArticle

Chemotherapy
Non-Small Cell Lung Carcinoma
Cells
Drug Therapy
Mutation
1 Citation (Scopus)

Effect of FGF/FGFR pathway blocking on lung adenocarcinoma and its cancer-associated fibroblasts

Hegab, A. E., Ozaki, M., Kameyama, N., Gao, J., Kagawa, S., Yasuda, H., Soejima, K., Yin, Y., Guzy, R. D., Nakamura, Y., Ornitz, D. M. & Betsuyaku, T., 2019 Jan 1, In : Journal of Pathology.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Fibroblast Growth Factors
Neoplasms
Lung
Cancer-Associated Fibroblasts
6 Citations (Scopus)

Efficacy of afatinib or osimertinib plus cetuximab combination therapy for non-small-cell lung cancer with EGFR exon 20 insertion mutations

Hasegawa, H., Yasuda, H., Hamamoto, J., Masuzawa, K., Tani, T., Nukaga, S., Hirano, T., Kobayashi, K., Manabe, T., Terai, H., Ikemura, S., Kawada, I., Naoki, K. & Soejima, K., 2019 Jan 1, In : Lung Cancer. 127, p. 146-152 7 p.

Research output: Contribution to journalArticle

Insertional Mutagenesis
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Exons
Therapeutics

Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations

Ikemura, S., Yasuda, H., Matsumoto, S., Kamada, M., Hamamoto, J., Masuzawa, K., Kobayashi, K., Manabe, T., Arai, D., Nakachi, I., Kawada, I., Ishioka, K., Nakamura, M., Namkoong, H., Naoki, K., Ono, F., Araki, M., Kanada, R., Ma, B., Hayashi, Y. & 8 others, Mimaki, S., Yoh, K., Kobayashi, S. S., Kohno, T., Okuno, Y., Goto, K., Tsuchihara, K. & Soejima, K., 2019 May 14, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10025-10030 6 p.

Research output: Contribution to journalArticle

Open Access
Molecular Dynamics Simulation
Lung Neoplasms
Mutation
Pharmaceutical Preparations
Protein-Tyrosine Kinases

Monomer preference of EGFR tyrosine kinase inhibitors influences the synergistic efficacy of combination therapy with cetuximab

Oashi, A., Yasuda, H., Kobayashi, K., Tani, T., Hamamoto, J., Masuzawa, K., Manabe, T., Terai, H., Ikemura, S., Kawada, I., Naoki, K. & Soejima, K., 2019 Jan 1, In : Molecular cancer therapeutics. 18, 9, p. 1593-1601 9 p.

Research output: Contribution to journalArticle

Dimerization
Protein-Tyrosine Kinases
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Therapeutics

TAS6417/CLN-081 Is a Pan-Mutation-Selective EGFR Tyrosine Kinase Inhibitor with a Broad Spectrum of Preclinical Activity against Clinically Relevant EGFR Mutations

Udagawa, H., Hasako, S., Ohashi, A., Fujioka, R., Hakozaki, Y., Shibuya, M., Abe, N., Komori, T., Haruma, T., Terasaka, M., Fujita, R., Hashimoto, A., Funabashi, K., Yasuda, H., Miyadera, K., Goto, K., Costa, D. B. & Kobayashi, S. S., 2019 Nov 1, In : Molecular cancer research : MCR. 17, 11, p. 2233-2243 11 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Mutation
Exons
Lung Neoplasms
Insertional Mutagenesis
2018
3 Citations (Scopus)

Comparison of detection methods of EGFR T790M mutations using plasma, serum, and tumor tissue in EGFR-TKI-resistant non-small cell lung cancer

Kobayashi, K., Naoki, K., Manabe, T., Masuzawa, K., Hasegawa, H., Yasuda, H., Kawada, I., Soejima, K. & Betsuyaku, T., 2018 Jun 6, In : OncoTargets and Therapy. 11, p. 3335-3343 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Biopsy
Mutation
Serum
Neoplasms
7 Citations (Scopus)

EGFR exon 20 insertion mutations display sensitivity to HSP90 inhibition in preclinical models and lung adenocarcinomas

Jorge, S. E., Lucena-Araujo, A. R., Yasuda, H., Piotrowska, Z., Oxnard, G. R., Rangachari, D., Huberman, M. S., Sequist, L. V., Kobayashi, S. S. & Costa, D. B., 2018 Dec 15, In : Clinical Cancer Research. 24, 24, p. 6548-6555 8 p.

Research output: Contribution to journalArticle

Insertional Mutagenesis
Exons
Mutation
Adenocarcinoma of lung
Lung Neoplasms

Egfr-mutant non-small cell lung cancer accompanied by transient asymptomatic pulmonary opacities successfully treated with “stop-and-go” osimertinib

Kobayashi, K., Naoki, K., Kuroda, A., Yasuda, H., Kawada, I., Soejima, K. & Betsuyaku, T., 2018 Jan 1, In : Internal Medicine. 57, 7, p. 1007-1010 4 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung
Epidermal Growth Factor Receptor
Tomography
Interstitial Lung Diseases
5 Citations (Scopus)

Intermittent exposure to cigarette smoke increases lung tumors and the severity of emphysema more than continuous exposure

Kameyama, N., Chubachi, S., Hegab, A. E., Yasuda, H., Kagawa, S., Tsutsumi, A., Fukunaga, K., Shimoda, M., Kanai, Y., Soejima, K. & Betsuyaku, T., 2018 Aug 1, In : American Journal of Respiratory Cell and Molecular Biology. 59, 2, p. 179-188 10 p.

Research output: Contribution to journalArticle

Emphysema
Smoke
Tobacco Products
Tumors
Lung
5 Citations (Scopus)

Pharmacological and structural characterizations of naquotinib, a novel third-generation EGFR tyrosine kinase inhibitor, in EGFR-mutated non–small cell lung cancer

Hirano, T., Yasuda, H., Hamamoto, J., Nukaga, S., Masuzawa, K., Kawada, I., Naoki, K., Niimi, T., Mimasu, S., Sakagami, H., Soejima, K. & Betsuyaku, T., 2018 Apr 1, In : Molecular Cancer Therapeutics. 17, 4, p. 740-750 11 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Pharmacology
Exons

Prognostic Understanding at Diagnosis and Associated Factors in Patients with Advanced Lung Cancer and Their Caregivers

Sato, T., Soejima, K., Fujisawa, D., Takeuchi, M., Arai, D., Nakachi, I., Naoki, K., Kawada, I., Yasuda, H., Ishioka, K., Nukaga, S., Kobayashi, K., Masaki, K., Inoue, T., Hikima, K., Nakamura, M., Ohgino, K., Oyamada, Y., Funatsu, Y., Terashima, T. & 5 others, Miyao, N., Sayama, K., Saito, F., Sakamaki, F. & Betsuyaku, T., 2018 Jan 1, (Accepted/In press) In : Oncologist.

Research output: Contribution to journalArticle

Caregivers
Lung Neoplasms
Anxiety
Depression
Neoplasms
8 Citations (Scopus)

Real-world Efficacy and Safety of Nivolumab for Advanced Non-Small-cell Lung Cancer: A Retrospective Multicenter Analysis

Kobayashi, K., Nakachi, I., Naoki, K., Satomi, R., Nakamura, M., Inoue, T., Tateno, H., Sakamaki, F., Sayama, K., Terashima, T., Koh, H., Abe, T., Nishino, M., Arai, D., Yasuda, H., Kawada, I., Soejima, K. & Betsuyaku, T., 2018 Jan 1, (Accepted/In press) In : Clinical Lung Cancer.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Disease-Free Survival
Safety
Mutation
Confidence Intervals

Secondary brain neoplasm after stereotactic radiosurgery in patients with metastatic non-small cell lung cancer

Nukaga, S., Naoki, K., Yasuda, H., Kawada, I., Ohara, K., Soejima, K. & Betsuyaku, T., 2018 Jan 1, In : Internal Medicine. 57, 16, p. 2383-2387 5 p.

Research output: Contribution to journalArticle

Radiosurgery
Non-Small Cell Lung Carcinoma
Brain Neoplasms
Radiation-Induced Neoplasms
Neoplasm Metastasis
Quality of Life
Skin
Social Adjustment
Dermatology
Neoplasms
2 Citations (Scopus)

The FGF2 aptamer inhibits the growth of FGF2-FGFR pathway driven lung cancer cells

Hamamoto, J., Yasuda, H., Nonaka, Y., Fujiwara, M., Nakamura, Y., Soejima, K. & Betsuyaku, T., 2018 Jan 1, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Lung Neoplasms
Cells
Growth
Cell proliferation
4 Citations (Scopus)

Tumor associated macrophages support the growth of FGF9-induced lung adenocarcinoma by multiple mechanisms

Hegab, A. E., Ozaki, M., Kagawa, S., Hamamoto, J., Yasuda, H., Naoki, K., Soejima, K., Yin, Y., Kinoshita, T., Yaguchi, T., Kawakami, Y., Ornitz, D. M. & Betsuyaku, T., 2018 May 1, In : Lung Cancer. 119, p. 25-35 11 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Macrophages
Growth
Neoplasms
Adenocarcinoma of lung
2017
35 Citations (Scopus)

Amplification of EGFR wild-type alleles in non-small cell lung cancer cells confers acquired resistance to mutation-selective EGFR tyrosine kinase inhibitors

Nukaga, S., Yasuda, H., Tsuchihara, K., Hamamoto, J., Masuzawa, K., Kawada, I., Naoki, K., Matsumoto, S., Mimaki, S., Ikemura, S., Goto, K., Betsuyaku, T. & Soejima, K., 2017 Apr 15, In : Cancer Research. 77, 8, p. 2078-2089 12 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Alleles
Mutation
Lung Neoplasms
10 Citations (Scopus)

Characterization of the efficacies of osimertinib and nazartinib against cells expressing clinically relevant epidermal growth factor receptor mutations

Masuzawa, K., Yasuda, H., Hamamoto, J., Nukaga, S., Hirano, T., Kawada, I., Naoki, K., Soejima, K. & Betsuyaku, T., 2017 Jan 1, In : Oncotarget. 8, 62, p. 105479-105491 13 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Mutation
Inhibitory Concentration 50
osimertinib
Exons
10 Citations (Scopus)

Clinical and pathological characteristics of EGFR mutation in operable early-stage lung adenocarcinoma

Yotsukura, M., Yasuda, H., Shigenobu, T., Kaseda, K., Masai, K., Hayashi, Y., Hishida, T., Ohtsuka, T., Naoki, K., Soejima, K., Betsuyaku, T. & Asamura, H., 2017 Jul 1, In : Lung Cancer. 109, p. 45-51 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Mutation
Neoplasms
Exons
Adenocarcinoma of lung
4 Citations (Scopus)

Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung

Kuroda, A., Hegab, A. E., Jingtao, G., Yamashita, S., Hizawa, N., Sakamoto, T., Yamada, H., Suzuki, S., Ishii, M., Namkoong, H., Asakura, T., Ozaki, M., Yasuda, H., Hamamoto, J., Kagawa, S., Soejima, K. & Betsuyaku, T., 2017 Apr 21, In : Respiratory Research. 18, 1, 69.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Lung
Genes
Stem Cells
Transgenic Mice
3 Citations (Scopus)

Non-small cell lung cancer PC-9 cells exhibit increased sensitivity to gemcitabine and vinorelbine upon acquiring resistance to EGFR-tyrosine kinase inhibitors

Hamamoto, J., Yasuda, H., Aizawa, K., Nishino, M., Nukaga, S., Hirano, T., Kawada, I., Naoki, K., Betsuyaku, T. & Soejima, K., 2017, In : Oncology Letters. 14, 3, p. 3559-3565 7 p.

Research output: Contribution to journalArticle

gemcitabine
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Lung Neoplasms
13 Citations (Scopus)

Osimertinib for EGFR T790M mutation-positive non-small cell lung cancer

Soejima, K., Yasuda, H. & Hirano, T., 2017 Jan 2, In : Expert Review of Clinical Pharmacology. 10, 1, p. 31-38 8 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Mutation
Lung Neoplasms
16 Citations (Scopus)

Overcoming EGFR bypass signal-induced acquired resistance to ALK tyrosine kinase inhibitors in ALK-translocated lung cancer

Miyawaki, M., Yasuda, H., Tani, T., Hamamoto, J., Arai, D., Ishioka, K., Ohgino, K., Nukaga, S., Hirano, T., Kawada, I., Naoki, K., Hayashi, Y., Betsuyaku, T. & Soejima, K., 2017 Jan 1, In : Molecular Cancer Research. 15, 1, p. 106-114 9 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Lung Neoplasms
Gene Rearrangement
Non-Small Cell Lung Carcinoma
anaplastic lymphoma kinase

Sternoclavicular joint osteomyelitis extending to lung abscess complicated by Staphylococcal infective endocarditis

Masuzawa, K., Asakura, T., Ishii, M., Yasuda, H., Sugiura, H. & Betsuyaku, T., 2017, In : IDCases. 9, p. 36-37 2 p.

Research output: Contribution to journalArticle

Sternoclavicular Joint
Lung Abscess
Osteomyelitis
Endocarditis

Suspected accelerated disease progression after discontinuation of nintedanib in patients with idiopathic pulmonary fibrosis: Two case reports

Okamori, S., Asakura, T., Masuzawa, K., Yasuda, H., Kamata, H., Ishii, M. & Betsuyaku, T., 2017 Dec 1, In : Medicine (United States). 96, 49, e9081.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Disease Progression
Steroids
Therapeutics
nintedanib
7 Citations (Scopus)
Erythema Multiforme
Interstitial Lung Diseases
Melanoma
CTLA-4 Antigen
Pharmaceutical Preparations
10 Citations (Scopus)

Variant CD44 expression is enriching for a cell population with cancer stem cell-like characteristics in human lung adenocarcinoma

Nishino, M., Ozaki, M., Hegab, A. E., Hamamoto, J., Kagawa, S., Arai, D., Yasuda, H., Naoki, K., Soejima, K., Saya, H. & Betsuyaku, T., 2017 Jun 1, In : Journal of Cancer. 8, 10, p. 1774-1785 12 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Aldehyde Dehydrogenase
Population
Cell Line
leucyl-alanyl-arginyl-leucyl-leucyl-threonine
2016
23 Citations (Scopus)

Activation of EGFR bypass signaling by TGFa overexpression induces acquired resistance to alectinib in ALK-translocated lung cancer cells

Tani, T., Yasuda, H., Hamamoto, J., Kuroda, A., Arai, D., Ishioka, K., Ohgino, K., Miyawaki, M., Kawada, I., Naoki, K., Hayashi, Y., Betsuyaku, T. & Soejima, K., 2016 Jan 1, In : Molecular Cancer Therapeutics. 15, 1, p. 162-171 10 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Non-Small Cell Lung Carcinoma
Gene Rearrangement
CH5424802
Receptor Protein-Tyrosine Kinases
2015
6 Citations (Scopus)

A phase II study of biweekly paclitaxel and carboplatin in elderly patients with advanced non-small cell lung cancer

Soejima, K., Naoki, K., Ishioka, K., Nakamura, M., Nakatani, M., Kawada, I., Watanabe, H., Nakachi, I., Yasuda, H., Satomi, R., Nakayama, S., Yoda, S., Ikemura, S., Terai, H., Sato, T., Ohgino, K., Arai, D., Tani, T., Kuroda, A., Nishino, M. & 1 others, Betsuyaku, T., 2015, In : Cancer Chemotherapy and Pharmacology. 75, 3, p. 513-519 7 p.

Research output: Contribution to journalArticle

Carboplatin
Paclitaxel
Non-Small Cell Lung Carcinoma
Chemotherapy
Cells
3 Citations (Scopus)

A Phase II study of S-1 and irinotecan combination therapy in previously treated patients with advanced non-small cell lung cancer

Ikemura, S., Naoki, K., Yasuda, H., Kawada, I., Yoda, S., Terai, H., Sato, T., Ishioka, K., Arai, D., Ohgino, K., Kamata, H., Miyata, J., Kabata, H., Betsuyaku, T. & Soejima, K., 2015 Apr 1, In : Japanese Journal of Clinical Oncology. 45, 4, p. 356-361 6 p.

Research output: Contribution to journalArticle

irinotecan
Non-Small Cell Lung Carcinoma
Body Surface Area
Therapeutics
Disease-Free Survival
18 Citations (Scopus)

Characterization of the cell of origin and propagation potential of the fibroblast growth factor 9-induced mouse model of lung adenocarcinoma

Arai, D., Hegab, A. E., Soejima, K., Kuroda, A., Ishioka, K., Yasuda, H., Naoki, K., Kagawa, S., Hamamoto, J., Yin, Y., Ornitz, D. M. & Betsuyaku, T., 2015 Mar 1, In : Journal of Pathology. 235, 4, p. 593-605 13 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Neoplasms
Lung
Epithelium
Lung Neoplasms
16 Citations (Scopus)

FOXD1 expression is associated with poor prognosis in non-small cell lung cancer

Nakayama, S., Soejima, K., Yasuda, H., Yoda, S., Satomi, R., Ikemura, S., Terai, H., Sato, T., Yamaguchi, N., Hamamoto, J., Arai, D., Ishioka, K., Ohgino, K., Naoki, K. & Betsuyaku, T., 2015 Jan 1, In : Anticancer Research. 35, 1, p. 261-268 8 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung Neoplasms
Cell Proliferation
Cell Line
Messenger RNA
48 Citations (Scopus)

In vitro modeling to determine mutation specificity of EGFR tyrosine kinase inhibitors against clinically relevant EGFR mutants in non-small-cell lung cancer

Hirano, T., Yasuda, H., Tani, T., Hamamoto, J., Oashi, A., Ishioka, K., Arai, D., Nukaga, S., Miyawaki, M., Kawada, I., Naoki, K., Costa, D. B., Kobayashi, S. S., Betsuyaku, T. & Soejima, K., 2015, In : Oncotarget. 6, 36, p. 38789-38803 15 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Mutation
Insertional Mutagenesis
Exons
5 Citations (Scopus)

Long-term exposure to gefitinib induces acquired resistance through DNA methylation changes in the EGFR-mutant PC9 lung cancer cell line

Terai, H., Soejima, K., Yasuda, H., Sato, T., Naoki, K., Ikemura, S., Arai, D., Ohgino, K., Ishioka, K., Hamamoto, J., Kanai, Y. & Betsuyaku, T., 2015 Jan 1, In : International Journal of Oncology. 46, 1, p. 430-436 7 p.

Research output: Contribution to journalArticle

DNA Methylation
Lung Neoplasms
Cell Line
Genes
Messenger RNA
11 Citations (Scopus)

Methylation-induced downregulation of TFPI-2 causes TMPRSS4 overexpression and contributes to oncogenesis in a subset of non-small-cell lung carcinoma

Hamamoto, J., Soejima, K., Naoki, K., Yasuda, H., Hayashi, Y., Yoda, S., Nakayama, S., Satomi, R., Terai, H., Ikemura, S., Sato, T., Arai, D., Ishioka, K., Ohgino, K. & Betsuyaku, T., 2015 Jan 1, In : Cancer Science. 106, 1, p. 34-42 9 p.

Research output: Contribution to journalArticle

Serine Proteases
Non-Small Cell Lung Carcinoma
Methylation
Carcinogenesis
Down-Regulation
28 Citations (Scopus)

Mimicking the niche of lung epithelial stem cells and characterization of several effectors of their in vitro behavior

Hegab, A. E., Arai, D., Gao, J., Kuroda, A., Yasuda, H., Ishii, M., Naoki, K., Soejima, K. & Betsuyaku, T., 2015 Jul 1, In : Stem Cell Research. 15, 1, p. 109-121 13 p.

Research output: Contribution to journalArticle

Stem Cells
Epithelial Cells
Lung
Stem Cell Niche
Stromal Cells
9 Citations (Scopus)

Multiple roles of extracellular fibroblast growth factors in lung cancer cells

Suzuki, T., Yasuda, H., Funaishi, K., Arai, D., Ishioka, K., Ohgino, K., Tani, T., Hamamoto, J., Ohashi, A., Naoki, K., Betsuyaku, T. & Soejima, K., 2015 Jan 1, In : International Journal of Oncology. 46, 1, p. 423-429 7 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factors
Lung Neoplasms
Small Cell Lung Carcinoma
Fibroblast Growth Factor 2
Non-Small Cell Lung Carcinoma
7 Citations (Scopus)

Prognostic implication of PTPRH hypomethylation in non-small cell lung cancer

Sato, T., Soejima, K., Arai, E., Hamamoto, J., Yasuda, H., Arai, D., Ishioka, K., Ohgino, K., Naoki, K., Kohno, T., Tsuta, K., Watanabe, S. I., Kanai, Y. & Betsuyaku, T., 2015 Sep 1, In : Oncology Reports. 34, 3, p. 1137-1145 9 p.

Research output: Contribution to journalArticle

DNA Methylation
Non-Small Cell Lung Carcinoma
Messenger RNA
decitabine
Protein Tyrosine Phosphatases
2014
24 Citations (Scopus)

Claudin-1 is a novel target of miR-375 in non-small-cell lung cancer

Yoda, S., Soejima, K., Hamamoto, J., Yasuda, H., Nakayama, S., Satomi, R., Terai, H., Ikemura, S., Sato, T., Naoki, K. & Betsuyaku, T., 2014, In : Lung Cancer. 85, 3, p. 366-372 7 p.

Research output: Contribution to journalArticle

Claudin-1
Non-Small Cell Lung Carcinoma
Luciferases
Cell Line
Squamous Cell Carcinoma
54 Citations (Scopus)

Dual ALK and EGFR inhibition targets a mechanism of acquired resistance to the tyrosine kinase inhibitor crizotinib in ALK rearranged lung cancer

Yamaguchi, N., Lucena-Araujo, A. R., Nakayama, S., de Figueiredo-Pontes, L. L., Gonzalez, D. A., Yasuda, H., Kobayashi, S. & Costa, D. B., 2014 Jan, In : Lung Cancer. 83, 1, p. 37-43 7 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Lung Neoplasms
Non-Small Cell Lung Carcinoma
Clone Cells
crizotinib
25 Citations (Scopus)

Expression of fibroblast growth factor 9 is associated with poor prognosis in patients with resected non-small cell lung cancer

Ohgino, K., Soejima, K., Yasuda, H., Hayashi, Y., Hamamoto, J., Naoki, K., Arai, D., Ishioka, K., Sato, T., Terai, H., Ikemura, S., Yoda, S., Tani, T., Kuroda, A. & Betsuyaku, T., 2014 Jan, In : Lung Cancer. 83, 1, p. 90-96 7 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Non-Small Cell Lung Carcinoma
Fibroblast Growth Factors
Lung
Oligonucleotide Array Sequence Analysis
8 Citations (Scopus)

Identification and Characterization of ALK Kinase Splicing Isoforms in Non-Small-Cell Lung Cancer

De Figueiredo-Pontes, L. L., Wong, D. W. S., Tin, V. P. C., Chung, L. P., Yasuda, H., Yamaguchi, N., Nakayama, S., Jänne, P. A., Wong, M. P., Kobayashi, S. S. & Costa, D. B., 2014 Feb, In : Journal of Thoracic Oncology. 9, 2, p. 248-253 6 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Protein Isoforms
Phosphotransferases
anaplastic lymphoma kinase
Exons

Structural, biochemical, and clinical characterization of Epidermal Growth Factor Receptor (EGFR) exon 20 insertion mutations in lung cancer (Science Translational Medicine (2014) 6, (225er1))

Yasuda, H., Park, E., Yun, C. H., Sng, N. J., Lucena-Araujo, A. R., Yeo, W. L., Huberman, M. S., Cohen, D. W., Nakayama, S., Ishioka, K., Yamaguchi, N., Hanna, M., Oxnard, G. R., Lathan, C. S., Moran, T., Sequist, L. V., Chaft, J. E., Riely, G. J., Arcila, M. E., Soo, R. A. & 4 others, Meyerson, M., Eck, M. J., Kobayashi, S. S. & Costa, D. B., 2014 Feb 26, In : Science Translational Medicine. 6, 225, 225er1.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The efficacy, safety, and pharmacokinetics of biapenem administered thrice daily for the treatment of pneumonia in the elderly

Namkoong, H., Kameyama, Y., Yasuda, H., Nakayama, S., Kaneko, H., Kawashima, C., Terajima, T., Maezawa, K., Hayashi, T., Sandoh, M., Ishii, M., Tasaka, S., Kanayama, A., Kobayashi, I., Betsuyaku, T., Kizu, J., Iwata, S., Sato, Y. & Hasegawa, N., 2014, In : Journal of Infection and Chemotherapy. 20, 6, p. 356-360 5 p.

Research output: Contribution to journalArticle

biapenem
Pneumonia
Pharmacokinetics
Safety
Microbial Sensitivity Tests
36 Citations (Scopus)

β-catenin contributes to lung tumor development induced by EGFR mutations

Nakayama, S., Sng, N., Carretero, J., Welner, R., Hayashi, Y., Yamamoto, M., Tan, A. J., Yamaguchi, N., Yasuda, H., Li, D., Soejima, K., Soo, R. A., Costa, D. B., Wong, K. K. & Kobayashi, S. S., 2014 Oct 15, In : Cancer Research. 74, 20, p. 5891-5902 12 p.

Research output: Contribution to journalArticle

Catenins
Lung
Mutation
Neoplasms
Lung Neoplasms
2013
113 Citations (Scopus)

Activation of the FGF2-FGFR1 autocrine pathway: A novel mechanism of acquired resistance to gefitinib in NSCLC

Terai, H., Soejima, K., Yasuda, H., Nakayama, S., Hamamoto, J., Arai, D., Ishioka, K., Ohgino, K., Ikemura, S., Sato, T., Yoda, S., Satomi, R., Naoki, K. & Betsuyaku, T., 2013 Jul, In : Molecular Cancer Research. 11, 7, p. 759-767 9 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Non-Small Cell Lung Carcinoma
Epidermal Growth Factor Receptor
Cell Line
gefitinib
44 Citations (Scopus)

Identification of microRNAs differentially expressed between lung squamous cell carcinoma and lung adenocarcinoma

Hamamoto, J., Soejima, K., Yoda, S., Naoki, K., Nakayama, S., Satomi, R., Terai, H., Ikemura, S., Sato, T., Yasuda, H., Hayashi, Y., Sakamoto, M., Takebayashi, T. & Betsuyaku, T., 2013 Aug, In : Molecular Medicine Reports. 8, 2, p. 456-462 7 p.

Research output: Contribution to journalArticle

MicroRNAs
Squamous Cell Carcinoma
Non-Small Cell Lung Carcinoma
Lung
Adenocarcinoma
183 Citations (Scopus)

Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer

Yasuda, H., Park, E., Yun, C. H., Sng, N. J., Lucena-Araujo, A. R., Yeo, W. L., Huberman, M. S., Cohen, D. W., Nakayama, S., Ishioka, K., Yamaguchi, N., Hanna, M., Oxnard, G. R., Lathan, C. S., Moran, T., Sequist, L. V., Chaft, J. E., Riely, G. J., Arcila, M. E., Soo, R. A. & 4 others, Meyerson, M., Eck, M. J., Kobayashi, S. S. & Costa, D. B., 2013 Dec 18, In : Science Translational Medicine. 5, 216, 216ra177.

Research output: Contribution to journalArticle

Insertional Mutagenesis
Epidermal Growth Factor Receptor
Exons
Lung Neoplasms
Protein-Tyrosine Kinases
2012
275 Citations (Scopus)

EGFR exon 20 insertion mutations in non-small-cell lung cancer: Preclinical data and clinical implications

Yasuda, H., Kobayashi, S. & Costa, D. B., 2012 Jan, In : The Lancet Oncology. 13, 1

Research output: Contribution to journalArticle

Insertional Mutagenesis
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Exons
Protein-Tyrosine Kinases