• 1115 Citations
  • 20 h-Index
20042019
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Research Output 2004 2019

  • 1115 Citations
  • 20 h-Index
  • 39 Article
  • 3 Chapter
  • 2 Review article
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Article
2019
1 Citation (Scopus)

Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori–Infected CAPZA1-Overexpressing Cells

Tsugawa, H., Kato, C., Mori, H., Matsuzaki, J., Kameyama, K., Saya, H., Hatakeyama, M., Suematsu, M. & Suzuki, H., 2019 Jan 1, In : CMGH. 8, 3, p. 319-334 16 p.

Research output: Contribution to journalArticle

Open Access
Helicobacter
Neoplastic Stem Cells
Catenins
Protein Splicing
Histones

Neutrophil-activating Protein Polymorphism of Helicobacter pylori Determines the Host Risk of Dyspepsia

Matsuzaki, J., Tsugawa, H., Kashiwazaki, Y., Mori, H., Yamamoto, Y., Kameyama, H., Masaoka, T., Kanai, T. & Suzuki, H., 2019 Jan 1, In : CMGH. 8, 2, p. 295-297.e6

Research output: Contribution to journalArticle

Open Access
Dyspepsia
Helicobacter pylori neutrophil-activating protein A
2018
3 Citations (Scopus)

CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy

Tsugawa, H., Mori, H., Matsuzaki, J., Sato, A., Saito, Y., Imoto, M., Suematsu, M. & Suzuki, H., 2018 Jan 1, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalArticle

Lysosomal-Associated Membrane Protein 1
Low Density Lipoprotein Receptor-Related Protein-1
Autophagy
Helicobacter pylori
Actins
4 Citations (Scopus)

Inhibiting xCT improves 5-fluorouracil resistance of gastric cancer induced by CD44 variant 9 expression

Miyoshi, S., Tsugawa, H., Matsuzaki, J., Hirata, K., Mori, H., Saya, H., Kanai, T. & Suzuki, H., 2018 Nov 1, In : Anticancer Research. 38, 11, p. 6163-6170 8 p.

Research output: Contribution to journalArticle

Fluorouracil
Stomach Neoplasms
Neoplastic Stem Cells
Antiporters
Drug Therapy
2017
4 Citations (Scopus)

Enteric Glial Dysfunction Evoked by Apolipoprotein E Deficiency Contributes to Delayed Gastric Emptying

Fukuhara, S., Masaoka, T., Nishimura, S., Nakamura, M., Matsuzaki, J., Tsugawa, H., Miyoshi, S., Mori, H., Kawase, S., Shibata, S., Okano, H., Kanai, T. & Suzuki, H., 2017 Nov 2, (Accepted/In press) In : Digestive Diseases and Sciences. p. 1-11 11 p.

Research output: Contribution to journalArticle

Gastric Emptying
Apolipoproteins E
Neuroglia
Knockout Mice
Glial Fibrillary Acidic Protein
20 Citations (Scopus)

Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1

Pati, M. L., Groza, D., Riganti, C., Kopecka, J., Niso, M., Berardi, F., Hager, S., Heffeter, P., Hirai, M., Tsugawa, H., Kabe, Y., Suematsu, M. & Abate, C., 2017 Mar 1, In : Pharmacological Research. 117, p. 67-74 8 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Ligands
Membranes
Proteins
Heme
2016
20 Citations (Scopus)

Efficacy of 10-day Sitafloxacin-Containing Third-Line Rescue Therapies for Helicobacter pylori Strains Containing the gyrA Mutation

Mori, H., Suzuki, H., Matsuzaki, J., Tsugawa, H., Fukuhara, S., Miyoshi, S., Hirata, K., Seino, T., Matsushita, M., Masaoka, T. & Kanai, T., 2016 Aug 1, In : Helicobacter. 21, 4, p. 286-294 9 p.

Research output: Contribution to journalArticle

Helicobacter pylori
Mutation
Esomeprazole
Amoxicillin
Metronidazole
18 Citations (Scopus)

Rifabutin-based 10-day and 14-day triple therapy as a third-line and fourth-line regimen for Helicobacter pylori eradication: A pilot study

Mori, H., Suzuki, H., Matsuzaki, J., Tsugawa, H., Fukuhara, S., Miyoshi, S., Hirata, K., Seino, T., Matsushita, M., Nishizawa, T., Masaoka, T. & Kanai, T., 2016 Jun 1, In : United European Gastroenterology Journal. 4, 3, p. 380-387 8 p.

Research output: Contribution to journalArticle

Rifabutin
Helicobacter pylori
Therapeutics
Amoxicillin
Rifamycins
2015
2 Citations (Scopus)

BH3-only protein Bim is associated with the degree of Helicobacter pylori-induced gastritis and is localized to the mitochondria of inflammatory cells in the gastric mucosa

Akazawa, Y., Matsuda, K., Isomoto, H., Matsushima, K., Kido, Y., Urabe, S., Yamaghchi, N., Ohnita, K., Takeshima, F., Kondo, H., Tsugawa, H., Suzuki, H., Moss, J., Nakao, K. & Nakashima, M., 2015 Sep 1, In : International Journal of Medical Microbiology. 305, 6, p. 553-562 10 p.

Research output: Contribution to journalArticle

Gastritis
Gastric Mucosa
Helicobacter pylori
Mitochondria
Proteins
6 Citations (Scopus)

Nordihydroguaiaretic acid disrupts the antioxidant ability of Helicobacter pylori through the repression of SodB activity in vitro

Tsugawa, H., Mori, H., Matsuzaki, J., Masaoka, T., Hirayama, T., Nagasawa, H., Sakakibara, Y., Suematsu, M. & Suzuki, H., 2015, In : BioMed Research International. 2015, 734548.

Research output: Contribution to journalArticle

Masoprocol
Helicobacter pylori
Antioxidants
Stomach
Gerbillinae
2014
7 Citations (Scopus)

Mucosal expression of aquaporin-4 in the stomach of histamine type 2 receptor knockout mice and Helicobacter pylori-infected mice

Fukuhara, S., Matsuzaki, J., Tsugawa, H., Masaoka, T., Miyoshi, S., Mori, H., Fukushima, Y., Yasui, M., Kanai, T. & Suzuki, H., 2014 Dec 1, In : Journal of Gastroenterology and Hepatology (Australia). 29, S4, p. 53-59 7 p.

Research output: Contribution to journalArticle

Aquaporin 4
Histamine Receptors
Knockout Mice
Helicobacter pylori
Stomach
2013
45 Citations (Scopus)

Bile acids increase levels of microRNAs 221 and 222, leading to degradation of CDX2 during esophageal carcinogenesis

Matsuzaki, J., Suzuki, H., Tsugawa, H., Watanabe, M., Hossain, S., Arai, E., Saito, Y., Sekine, S., Akaike, T., Kanai, Y., Mukaisho, K. I., Auwerx, J. & Hibi, T., 2013 Dec, In : Gastroenterology. 145, 6, p. 1300-1311 12 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
MicroRNAs
Carcinogenesis
Adenocarcinoma
Barrett Esophagus
65 Citations (Scopus)

CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence

Hirata, K., Suzuki, H., Imaeda, H., Matsuzaki, J., Tsugawa, H., Nagano, O., Asakura, K., Saya, H. & Hibi, T., 2013 Jul 23, In : British Journal of Cancer. 109, 2, p. 379-386 8 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Recurrence
Apoptosis Regulatory Proteins
Mucins
MicroRNAs
2 Citations (Scopus)

Correction: Overexpression of miR-142-5p and miR-155 in gastric mucosa-associated lymphoid tissue (MALT) lymphoma resistant to Helicobacter pylori eradication (PLoS ONE)

Saito, Y., Suzuki, H., Tsugawa, H., Imaeda, H., Matsuzaki, J., Hirata, K., Hosoe, N., Nakamura, M., Mukai, M., Saito, H. & Hibi, T., 2013 Jul 31, In : PLoS One. 8, 7

Research output: Contribution to journalArticle

Tissue
Mucous Membrane

Erratum: Enhancement of amoxicillin resistance after unsuccessful helicobacter pylori eradication (Antimicrobial Agents and Chemotherapy (2011) 55:6 (3012-3014)

Nishizawa, T., Suzuki, H., Tsugawa, H., Muraoka, H., Matsuzaki, J., Hirata, K., Ikeda, F., Takahashi, M. & Hibi, T., 2013 Feb, In : Antimicrobial Agents and Chemotherapy. 57, 2, p. 1106 1 p.

Research output: Contribution to journalArticle

Amoxicillin
Anti-Infective Agents
Helicobacter pylori
Drug Therapy
12 Citations (Scopus)
Interstitial Cells of Cajal
Pyloric Antrum
Heme Oxygenase-1
Experimental Diabetes Mellitus
Streptozocin
54 Citations (Scopus)

The tumor suppressor microRNA-29c is downregulated and restored by celecoxib in human gastric cancer cells

Saito, Y., Suzuki, H., Imaeda, H., Matsuzaki, J., Hirata, K., Tsugawa, H., Hibino, S., Kanai, Y., Saito, H. & Hibi, T., 2013 Apr 15, In : International Journal of Cancer. 132, 8, p. 1751-1760 10 p.

Research output: Contribution to journalArticle

Celecoxib
MicroRNAs
Stomach Neoplasms
Down-Regulation
Neoplasms
2012
15 Citations (Scopus)

Development of a novel microRNA promoter microarray for ChIP-on-chip assay to identify epigenetically regulated microRNAs

Saito, Y., Suzuki, H., Taya, T., Nishizawa, M., Tsugawa, H., Matsuzaki, J., Hirata, K., Saito, H. & Hibi, T., 2012 Sep 14, In : Biochemical and Biophysical Research Communications. 426, 1, p. 33-37 5 p.

Research output: Contribution to journalArticle

Chromatin Immunoprecipitation
Microarrays
MicroRNAs
Chromatin
Assays
38 Citations (Scopus)

Efficacy of sitafloxacin-based rescue therapy for Helicobacter pylori after failures of first- and second-line therapies

Matsuzaki, J., Suzuki, H., Nishizawa, T., Hirata, K., Tsugawa, H., Saito, Y., Okada, S., Fukuhara, S. & Hibi, T., 2012 Mar, In : Antimicrobial Agents and Chemotherapy. 56, 3, p. 1643-1645 3 p.

Research output: Contribution to journalArticle

Helicobacter pylori
Mutation
Clarithromycin
Metronidazole
Therapeutics
8 Citations (Scopus)

FecA1, a bacterial iron transporter, determines the survival of Helicobacter pylori in the stomach

Tsugawa, H., Suzuki, H., Matsuzaki, J., Hirata, K. & Hibi, T., 2012 Mar 15, In : Free Radical Biology and Medicine. 52, 6, p. 1003-1010 8 p.

Research output: Contribution to journalArticle

Metronidazole
Helicobacter pylori
Stomach
Iron
Chemical activation
6 Citations (Scopus)

Molecular approaches and modern clinical strategies for the management of Helicobacter pylori infection in Japan

Suzuki, H., Nishizawa, T., Tsugawa, H. & Hibi, T., 2012 Dec, In : Keio Journal of Medicine. 61, 4, p. 109-119 11 p.

Research output: Contribution to journalArticle

Helicobacter Infections
Helicobacter pylori
Japan
Gastritis
Peptic Ulcer
80 Citations (Scopus)

Overexpression of miR-142-5p and miR-155 in Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Resistant to Helicobacter pylori Eradication

Saito, Y., Suzuki, H., Tsugawa, H., Imaeda, H., Matsuzaki, J., Hirata, K., Hosoe, N., Nakamura, M., Mukai, M., Saito, H. & Hibi, T., 2012 Nov 28, In : PLoS One. 7, 11, e47396.

Research output: Contribution to journalArticle

Marginal Zone B-Cell Lymphoma
Helicobacter pylori
gastric mucosa
Gastric Mucosa
lymphoma
124 Citations (Scopus)

Reactive oxygen species-induced autophagic degradation of helicobacter pylori CagA is specifically suppressed in cancer stem-like cells

Tsugawa, H., Suzuki, H., Saya, H., Hatakeyama, M., Hirayama, T., Hirata, K., Nagano, O., Matsuzaki, J. & Hibi, T., 2012 Dec 13, In : Cell Host and Microbe. 12, 6, p. 764-777 14 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Helicobacter pylori
Stomach Neoplasms
Reactive Oxygen Species
Autophagy
94 Citations (Scopus)

Roles of oxidative stress in stomach disorders

Suzuki, H., Nishizawa, T., Tsugawa, H., Mogami, S. & Hibi, T., 2012, In : Journal of Clinical Biochemistry and Nutrition. 50, 1, p. 35-39 5 p.

Research output: Contribution to journalArticle

Oxidative stress
Stomach
Oxidative Stress
Pathogens
Nutrition
2011
45 Citations (Scopus)

Dysfunctional gastric emptying with down-regulation of muscle-specific MicroRNAs in helicobacter pylori-infected mice

Saito, Y., Suzuki, H., Tsugawa, H., Suzuki, S., Matsuzaki, J., Hirata, K. & Hibi, T., 2011 Jan, In : Gastroenterology. 140, 1, p. 189-198 10 p.

Research output: Contribution to journalArticle

Gastric Emptying
Pylorus
MicroRNAs
Helicobacter pylori
Down-Regulation
28 Citations (Scopus)

Enhanced bacterial efflux system is the first step to the development of metronidazole resistance in Helicobacter pylori

Tsugawa, H., Suzuki, H., Muraoka, H., Ikeda, F., Hirata, K., Matsuzaki, J., Saito, Y. & Hibi, T., 2011 Jan 14, In : Biochemical and Biophysical Research Communications. 404, 2, p. 656-660 5 p.

Research output: Contribution to journalArticle

Metronidazole
Helicobacter pylori
Pumps
25 Citations (Scopus)

Enhancement of amoxicillin resistance after unsuccessful Helicobacter pylori eradication

Nishizawa, T., Suzuki, H., Tsugawa, H., Muraoka, H., Matsuzaki, J., Hirata, K., Ikeda, F., Takahashi, M. & Hibi, T., 2011 Jun, In : Antimicrobial Agents and Chemotherapy. 55, 6, p. 3012-3014 3 p.

Research output: Contribution to journalArticle

Amoxicillin
Helicobacter pylori
Clarithromycin
Metronidazole
21 Citations (Scopus)

Helicobacter pylori resistance to rifabutin in the last 7 years

Nishizawa, T., Suzuki, H., Matsuzaki, J., Muraoka, H., Tsugawa, H., Hirata, K. & Hibi, T., 2011 Nov, In : Antimicrobial Agents and Chemotherapy. 55, 11, p. 5374-5375 2 p.

Research output: Contribution to journalArticle

Rifabutin
Helicobacter pylori
Rifampin
Pulmonary Tuberculosis
Point Mutation
33 Citations (Scopus)

Two amino acids mutation of ferric uptake regulator determines helicobacter pylori resistance to metronidazole

Tsugawa, H., Suzuki, H., Satoh, K., Hirata, K., Matsuzaki, J., Saito, Y., Suematsu, M. & Hibi, T., 2011 Jan 1, In : Antioxidants and Redox Signaling. 14, 1, p. 15-23 9 p.

Research output: Contribution to journalArticle

Metronidazole
Helicobacter pylori
Amino Acids
Mutation
Superoxides
2010
20 Citations (Scopus)

Acid suppression by proton pump inhibitors enhances aquaporin-4 and KCNQ1 expression in gastric fundic parietal cells in mouse

Matsuzaki, J., Suzuki, H., Minegishi, Y., Sugai, E., Tsugawa, H., Yasui, M. & Hibi, T., 2010 Dec, In : Digestive Diseases and Sciences. 55, 12, p. 3339-3348 10 p.

Research output: Contribution to journalArticle

Gastric Parietal Cells
Aquaporin 4
Proton Pump Inhibitors
Lansoprazole
Acids
62 Citations (Scopus)

Contribution of efflux pumps to clarithromycin resistance in Helicobacter pylori

Hirata, K., Suzuki, H., Nishizawa, T., Tsugawa, H., Muraoka, H., Saito, Y., Matsuzaki, J. & Hibi, T., 2010, In : Journal of Gastroenterology and Hepatology (Australia). 25, SUPPL. 1

Research output: Contribution to journalArticle

Clarithromycin
Helicobacter pylori
Point Mutation
Drug Resistance
Messenger RNA
23 Citations (Scopus)

Delayed gastric emptying and disruption of the interstitial cells of Cajal network after gastric ischaemia and reperfusion

Suzuki, S., Suzuki, H., Horiguchi, K., Tsugawa, H., Matsuzaki, J., Takagi, T., Shimojima, N. & Hibi, T., 2010 May, In : Neurogastroenterology and Motility. 22, 5

Research output: Contribution to journalArticle

Interstitial Cells of Cajal
Gastric Emptying
Reperfusion
Stomach
Ischemia
12 Citations (Scopus)

Homology model of the DNA gyrase enzyme of Helicobacter pylori, a target of quinolone-based eradication therapy

Matsuzaki, J., Suzuki, H., Tsugawa, H., Nishizawa, T. & Hibi, T., 2010, In : Journal of Gastroenterology and Hepatology (Australia). 25, SUPPL. 1

Research output: Contribution to journalArticle

DNA Gyrase
Quinolones
Helicobacter pylori
Enzymes
Therapeutics
2009
142 Citations (Scopus)

Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells

Saito, Y., Suzuki, H., Tsugawa, H., Nakagawa, I., Matsuzaki, J., Kanai, Y. & Hibi, T., 2009 Jul 30, In : Oncogene. 28, 30, p. 2738-2744 7 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
MicroRNAs
Epigenomics
Stomach Neoplasms
Down-Regulation
2008
7 Citations (Scopus)

Alpha-ketoglutarate oxidoreductase, an essential salvage enzyme of energy metabolism, in coccoid form of Helicobacter pylori

Tsugawa, H., Suzuki, H., Nakagawa, I., Nishizawa, T., Saito, Y., Suematsu, M. & Hibi, T., 2008 Nov 7, In : Biochemical and Biophysical Research Communications. 376, 1, p. 46-51 6 p.

Research output: Contribution to journalArticle

2-oxoglutarate synthase
Coenzyme A-Transferases
Salvaging
Helicobacter pylori
Energy Metabolism
6 Citations (Scopus)

Primary structure and function of a cytotoxic outer-membrane protein (ComP) of Plesiomonas shigelloides

Tsugawa, H., Ogawa, A., Takehara, S., Kimura, M. & Okawa, Y., 2008 Apr, In : FEMS Microbiology Letters. 281, 1, p. 10-16 7 p.

Research output: Contribution to journalArticle

Plesiomonas
Membrane Proteins
Caco-2 Cells
Porins
Proteins
2007
20 Citations (Scopus)

Cell adherence-promoted activity of Plesiomonas shigelloides GroEL

Tsugawa, H., Ito, H., Ohshima, M. & Okawa, Y., 2007 Jan, In : Journal of Medical Microbiology. 56, 1, p. 23-29 7 p.

Research output: Contribution to journalArticle

Plesiomonas
Caco-2 Cells
Operon
Nucleotides
Cell Fractionation
2005
8 Citations (Scopus)

Invasive phenotype and apoptosis induction of Plesiomonas shigelloides P-1 strain to Caco-2 cells

Tsugawa, H., Ono, T., Murakami, H. & Okawa, Y., 2005, In : Journal of Applied Microbiology. 99, 6, p. 1435-1443 9 p.

Research output: Contribution to journalArticle

Plesiomonas
Plesiomonas shigelloides
Caco-2 Cells
apoptosis
Apoptosis
2004
24 Citations (Scopus)

Isolation and characterization of a cytotoxin produced by Plesiomonas shigelloides P-1 strain

Okawa, Y., Ohtomo, Y., Tsugawa, H., Matsuda, Y., Kobayashi, H. & Tsukamoto, T., 2004 Oct 1, In : FEMS Microbiology Letters. 239, 1, p. 125-130 6 p.

Research output: Contribution to journalArticle

Plesiomonas
Cytotoxins
Lipopolysaccharides
Cholera Toxin
Proteins