• 612 Citations
  • 14 h-Index
20002019

Research output per year

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Research Output

  • 612 Citations
  • 14 h-Index
  • 41 Article
  • 1 Comment/debate
  • 1 Short survey

Disseminated histoplasmosis from a calcified lung nodule after long-term corticosteroid therapy in an elderly Japanese patient: A case report

Kobayashi, K., Asakura, T., Kawada, I., Hasegawa, H., Chubachi, S., Ohara, K., Kuramoto, J., Sugiura, H., Fujishima, S., Iwata, S., Umeyama, T., Katano, H., Uwamino, Y., Miyazaki, Y., Kamei, K., Hasegawa, N. & Betsuyaku, T., 2019 Apr 1, In : Medicine. 98, 17, p. e15264

Research output: Contribution to journalArticle

Open Access

Efficacy of afatinib or osimertinib plus cetuximab combination therapy for non-small-cell lung cancer with EGFR exon 20 insertion mutations

Hasegawa, H., Yasuda, H., Hamamoto, J., Masuzawa, K., Tani, T., Nukaga, S., Hirano, T., Kobayashi, K., Manabe, T., Terai, H., Ikemura, S., Kawada, I., Naoki, K. & Soejima, K., 2019 Jan 1, In : Lung Cancer. 127, p. 146-152 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Long-lasting response to nivolumab for a patient with lynch syndrome-associated lung adenocarcinoma

Masuzawa, K., Asakura, T., Ikemura, S., Yasuda, H., Kawada, I., Takaoka, S., Hayashi, Y., Nakajima, T., Arai, M., Fukunaga, K. & Soejima, K., 2019, In : JCO Precision Oncology. 3, p. 74-78 5 p.

Research output: Contribution to journalArticle

Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations

Ikemura, S., Yasuda, H., Matsumoto, S., Kamada, M., Hamamoto, J., Masuzawa, K., Kobayashi, K., Manabe, T., Arai, D., Nakachi, I., Kawada, I., Ishioka, K., Nakamura, M., Namkoong, H., Naoki, K., Ono, F., Araki, M., Kanada, R., Ma, B., Hayashi, Y. & 8 others, Mimaki, S., Yoh, K., Kobayashi, S. S., Kohno, T., Okuno, Y., Goto, K., Tsuchihara, K. & Soejima, K., 2019 May 14, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10025-10030 6 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Monomer preference of EGFR tyrosine kinase inhibitors influences the synergistic efficacy of combination therapy with cetuximab

Oashi, A., Yasuda, H., Kobayashi, K., Tani, T., Hamamoto, J., Masuzawa, K., Manabe, T., Terai, H., Ikemura, S., Kawada, I., Naoki, K. & Soejima, K., 2019 Jan 1, In : Molecular cancer therapeutics. 18, 9, p. 1593-1601 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

Comparison of detection methods of EGFR T790M mutations using plasma, serum, and tumor tissue in EGFR-TKI-resistant non-small cell lung cancer

Kobayashi, K., Naoki, K., Manabe, T., Masuzawa, K., Hasegawa, H., Yasuda, H., Kawada, I., Soejima, K. & Betsuyaku, T., 2018 Jun 6, In : OncoTargets and Therapy. 11, p. 3335-3343 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Egfr-mutant non-small cell lung cancer accompanied by transient asymptomatic pulmonary opacities successfully treated with “stop-and-go” osimertinib

Kobayashi, K., Naoki, K., Kuroda, A., Yasuda, H., Kawada, I., Soejima, K. & Betsuyaku, T., 2018 Jan 1, In : Internal Medicine. 57, 7, p. 1007-1010 4 p.

Research output: Contribution to journalArticle

Pharmacological and structural characterizations of naquotinib, a novel third-generation EGFR tyrosine kinase inhibitor, in EGFR-mutated non–small cell lung cancer

Hirano, T., Yasuda, H., Hamamoto, J., Nukaga, S., Masuzawa, K., Kawada, I., Naoki, K., Niimi, T., Mimasu, S., Sakagami, H., Soejima, K. & Betsuyaku, T., 2018 Apr 1, In : Molecular Cancer Therapeutics. 17, 4, p. 740-750 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Prognostic Understanding at Diagnosis and Associated Factors in Patients with Advanced Lung Cancer and Their Caregivers

Sato, T., Soejima, K., Fujisawa, D., Takeuchi, M., Arai, D., Nakachi, I., Naoki, K., Kawada, I., Yasuda, H., Ishioka, K., Nukaga, S., Kobayashi, K., Masaki, K., Inoue, T., Hikima, K., Nakamura, M., Ohgino, K., Oyamada, Y., Funatsu, Y., Terashima, T. & 5 others, Miyao, N., Sayama, K., Saito, F., Sakamaki, F. & Betsuyaku, T., 2018 Jan 1, (Accepted/In press) In : Oncologist.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Real-world Efficacy and Safety of Nivolumab for Advanced Non-Small-cell Lung Cancer: A Retrospective Multicenter Analysis

Kobayashi, K., Nakachi, I., Naoki, K., Satomi, R., Nakamura, M., Inoue, T., Tateno, H., Sakamaki, F., Sayama, K., Terashima, T., Koh, H., Abe, T., Nishino, M., Arai, D., Yasuda, H., Kawada, I., Soejima, K. & Betsuyaku, T., 2018 Jan 1, (Accepted/In press) In : Clinical Lung Cancer.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Secondary brain neoplasm after stereotactic radiosurgery in patients with metastatic non-small cell lung cancer

Nukaga, S., Naoki, K., Yasuda, H., Kawada, I., Ohara, K., Soejima, K. & Betsuyaku, T., 2018 Jan 1, In : Internal Medicine. 57, 16, p. 2383-2387 5 p.

Research output: Contribution to journalArticle

Targeted Therapy-induced Facial Skin Toxicities: Impact on Quality of Life in Cancer Patients

Yagasaki, K., Komatsu, H., Soejima, K., Naoki, K., Kawada, I., Yasuda, H. & Hamamoto, Y., 2018 Apr 1, In : Asia-Pacific Journal of Oncology Nursing. 5, 2, p. 172-177 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017

Amplification of EGFR wild-type alleles in non-small cell lung cancer cells confers acquired resistance to mutation-selective EGFR tyrosine kinase inhibitors

Nukaga, S., Yasuda, H., Tsuchihara, K., Hamamoto, J., Masuzawa, K., Kawada, I., Naoki, K., Matsumoto, S., Mimaki, S., Ikemura, S., Goto, K., Betsuyaku, T. & Soejima, K., 2017 Apr 15, In : Cancer Research. 77, 8, p. 2078-2089 12 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Characterization of the efficacies of osimertinib and nazartinib against cells expressing clinically relevant epidermal growth factor receptor mutations

Masuzawa, K., Yasuda, H., Hamamoto, J., Nukaga, S., Hirano, T., Kawada, I., Naoki, K., Soejima, K. & Betsuyaku, T., 2017 Jan 1, In : Oncotarget. 8, 62, p. 105479-105491 13 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Edoxaban treatment for pulmonary arterial thromboembolism associated with azygous vein aneurysm

Mochimaru, T., Kawada, I., Chubachi, S., Tsutsumi, A., Hasegawa, H. & Betsuyaku, T., 2017 May 1, In : Respirology Case Reports. 5, 3, e00223.

Research output: Contribution to journalArticle

Non-small cell lung cancer PC-9 cells exhibit increased sensitivity to gemcitabine and vinorelbine upon acquiring resistance to EGFR-tyrosine kinase inhibitors

Hamamoto, J., Yasuda, H., Aizawa, K., Nishino, M., Nukaga, S., Hirano, T., Kawada, I., Naoki, K., Betsuyaku, T. & Soejima, K., 2017, In : Oncology Letters. 14, 3, p. 3559-3565 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Overcoming EGFR bypass signal-induced acquired resistance to ALK tyrosine kinase inhibitors in ALK-translocated lung cancer

Miyawaki, M., Yasuda, H., Tani, T., Hamamoto, J., Arai, D., Ishioka, K., Ohgino, K., Nukaga, S., Hirano, T., Kawada, I., Naoki, K., Hayashi, Y., Betsuyaku, T. & Soejima, K., 2017 Jan 1, In : Molecular Cancer Research. 15, 1, p. 106-114 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
8 Citations (Scopus)
2016

Activation of EGFR bypass signaling by TGFa overexpression induces acquired resistance to alectinib in ALK-translocated lung cancer cells

Tani, T., Yasuda, H., Hamamoto, J., Kuroda, A., Arai, D., Ishioka, K., Ohgino, K., Miyawaki, M., Kawada, I., Naoki, K., Hayashi, Y., Betsuyaku, T. & Soejima, K., 2016 Jan 1, In : Molecular cancer therapeutics. 15, 1, p. 162-171 10 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2015

A phase II study of biweekly paclitaxel and carboplatin in elderly patients with advanced non-small cell lung cancer

Soejima, K., Naoki, K., Ishioka, K., Nakamura, M., Nakatani, M., Kawada, I., Watanabe, H., Nakachi, I., Yasuda, H., Satomi, R., Nakayama, S., Yoda, S., Ikemura, S., Terai, H., Sato, T., Ohgino, K., Arai, D., Tani, T., Kuroda, A., Nishino, M. & 1 others, Betsuyaku, T., 2015 Mar, In : Cancer Chemotherapy and Pharmacology. 75, 3, p. 513-519 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

A Phase II study of S-1 and irinotecan combination therapy in previously treated patients with advanced non-small cell lung cancer

Ikemura, S., Naoki, K., Yasuda, H., Kawada, I., Yoda, S., Terai, H., Sato, T., Ishioka, K., Arai, D., Ohgino, K., Kamata, H., Miyata, J., Kabata, H., Betsuyaku, T. & Soejima, K., 2015 Apr 1, In : Japanese journal of clinical oncology. 45, 4, p. 356-361 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Dry pleurisy complicating solitary pulmonary nodules caused by Mycobacterium avium: A case report

Asakura, T., Ishii, M., Haraguchi, M., Kamiyama, I., Kono, M., Sakamaki, H., Emoto, K., Hayashi, Y., Sugiura, H., Kawada, I., Soejima, K., Namkoong, H., Tasaka, S., Hasegawa, N. & Betsuyaku, T., 2015 Oct 26, (Accepted/In press) In : Journal of Medical Case Reports.

Research output: Contribution to journalArticle

4 Citations (Scopus)

In vitro modeling to determine mutation specificity of EGFR tyrosine kinase inhibitors against clinically relevant EGFR mutants in non-small-cell lung cancer

Hirano, T., Yasuda, H., Tani, T., Hamamoto, J., Oashi, A., Ishioka, K., Arai, D., Nukaga, S., Miyawaki, M., Kawada, I., Naoki, K., Costa, D. B., Kobayashi, S. S., Betsuyaku, T. & Soejima, K., 2015 Jan 1, In : Oncotarget. 6, 36, p. 38789-38803 15 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)
2014

Dramatic antitumor effects of the dual MET/RON small-molecule inhibitor LY2801653 in non-small cell lung cancer

Kawada, I., Hasina, R., Arif, Q., Mueller, J., Smithberger, E., Husain, A. N., Vokes, E. E. & Salgia, R., 2014 Feb 1, In : Cancer Research. 74, 3, p. 884-895 12 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Met and PI3K/mTOR as a potential combinatorial therapeutic target in malignant pleural mesothelioma

Kanteti, R., Dhanasingh, I., Kawada, I., Lennon, F. E., Arif, Q., Bueno, R., Hasina, R., Husain, A. N., Vigneswaran, W., Seiwert, T., Kindler, H. L. & Salgia, R., 2014 Sep 15, In : PloS one. 9, 9, e105919.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2013

Critical role for the receptor tyrosine kinase EPHB4 in esophageal cancers

Hasina, R., Mollberg, N., Kawada, I., Mutreja, K., Kanade, G., Yala, S., Surati, M., Liu, R., Li, X., Zhou, Y., Ferguson, B. D., Nallasura, V., Cohen, K. S., Hyjek, E., Mueller, J., Kanteti, R., El Hashani, E., Kane, D., Shimada, Y., Lingen, M. W. & 9 others, Husain, A. N., Posner, M. C., Waxman, I., Villaflor, V. M., Ferguson, M. K., Varticovski, L., Vokes, E. E., Gill, P. & Salgia, R., 2013 Jan 1, In : Cancer Research. 73, 1, p. 184-194 11 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

O-6-methylguanine-deoxyribonucleic acid methyltransferase methylation enhances response to temozolomide treatment in esophageal cancer

Hasina, R., Surati, M., Kawada, I., Arif, Q., Carey, G., Kanteti, R., Husain, A., Ferguson, M., Vokes, E., Villaflor, V. & Salgia, R., 2013 Jan 1, In : Journal of Carcinogenesis. 12, 120632.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics: Relevance to lung cancer

Kawada, I., Hasina, R., Lennon, F. E., Bindokas, V. P., Usatyuk, P., Tan, Y. H. C., Krishnaswamy, S., Arif, Q., Carey, G., Hseu, R. D., Robinson, M., Tretiakova, M., Brand, T. M., Iida, M., Ferguson, M. K., Wheeler, D. L., Husain, A. N., Natarajan, V., Vokes, E. E., Singleton, P. A. & 1 others, Salgia, R., 2013 Jul 1, In : Cancer Biology and Therapy. 14, 7, p. 679-691 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2011

A phase i study of S-1 and irinotecan combination therapy in previously treated advanced non-small cell lung cancer patients

Yoda, S., Soejima, K., Yasuda, H., Naoki, K., Kawada, I., Watanabe, H., Nakachi, I., Satomi, R., Nakayama, S., Ikemura, S., Terai, H., Sato, T., Morosawa, M. & Asano, K., 2011 Mar 1, In : Cancer Chemotherapy and Pharmacology. 67, 3, p. 717-722 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Bronchoscopic Microsampling is a Useful Complementary Diagnostic Tool for Detecting Lung Cancer

Yasuda, H., Soejima, K., Nakayama, S., Kawada, I., Nakachi, I., Yoda, S., Satomi, R., Ikemura, S., Terai, H., Sato, T., Watanabe, H., Naoki, K., Hayashi, Y. & Ishizaka, A., 2011 Apr 1, In : Lung Cancer. 72, 1, p. 32-38 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Crizotinib. ALK/Met inhibitor, oncolytic

Nwizu, T., Kanteti, R., Kawada, I., Rolle, C., Vokes, E. E. & Salgia, R., 2011, In : Drugs of the Future. 36, 2, p. 91-98 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2010

Distinct epigenetic regulation of tumor suppressor genes in putative cancer stem cells of solid tumors

Yasuda, H., Soejima, K., Watanabe, H., Kawada, I., Nakachi, I., Yoda, S., Nakayama, S., Satomi, R., Ikemura, S., Terai, H., Sato, T., Suzuki, S., Matsuzaki, Y., Naoki, K. & Ishizaka, A., 2010 Dec 1, In : International journal of oncology. 37, 6, p. 1537-1546 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

FDG-PET imaging of benign pulmonary diseases

Terai, H., Soejima, K., Naoki, K., Kawada, I., Nakachi, I., Satomi, R., Nakayama, S., Yoda, S., Ikemura, S., Sato, T., Ishizaka, A. & Yasuda, H., 2010 Feb 15, In : Japanese Journal of Clinical Radiology. 55, 1, p. 163-172 10 p.

Research output: Contribution to journalArticle

The combination of multiple receptor tyrosine kinase inhibitor and mammalian target of rapamycin inhibitor overcomes erlotinib resistance in lung cancer cell lines through c-met inhibition

Nakachi, I., Naoki, K., Soejima, K., Kawada, I., Watanabe, H., Yasuda, H., Nakayama, S., Yoda, S., Satomi, R., Ikemura, S., Terai, H., Sato, T. & Ishizaka, A., 2010 Aug, In : Molecular Cancer Research. 8, 8, p. 1142-1151 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2008

An alternative method for screening EGFR mutation using RFLP in non-small cell lung cancer patients

Kawada, I., Soejima, K., Watanabe, H., Nakachi, I., Yasuda, H., Naoki, K., Kawamura, M., Eguchi, K., Kobayashi, K. & Ishizaka, A., 2008 Oct, In : Journal of Thoracic Oncology. 3, 10, p. 1096-1103 8 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Deregulation of histone lysine methyltransferases contributes to oncogenic transformation of human bronchoepithelial cells

Watanabe, H., Soejima, K., Yasuda, H., Kawada, I., Nakachi, I., Yoda, S., Naoki, K. & Ishizaka, A., 2008 Nov 3, In : Cancer Cell International. 8, 15.

Research output: Contribution to journalArticle

108 Citations (Scopus)

Long-term CT findings of X-linked agammaglobulinemia with bronchiectasis diagnosed in an adult

Ishiguro, T., Takayanagi, N., Kawada, I., Kurashima, K., Matsushita, A., Harasawa, K., Tsuchiya, N., Yoneda, K., Miyahara, Y., Yamaguchi, S., Yano, R., Tokunaga, D., Saito, H., Ubukata, M., Yanagisawa, T. & Sugita, Y., 2008 Apr, In : Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 46, 4, p. 331-335 5 p.

Research output: Contribution to journalArticle

Screening of epidermal growth factor receptor mutation in lung cancer

Kawada, I. & Soejima, K., 2008 Jun 1, In : Respiration and Circulation. 56, 6, p. 617-622 6 p.

Research output: Contribution to journalShort survey

2007

Comparison of 5 day short-course therapies for secondary infection in patients with chronic respiratory disease using gatifloxacin and levofloxacin

Nakamura, M., Hasegawa, N., Miyao, N., Nakajima, T., Terashima, T., Sakamaki, F., Hiraoka, R., Matsubara, H., Oyamada, Y., Yonemaru, M., Nishio, K., Shimada, N., Kawada, I., Naoki, K., Tasaka, S., Nishimura, T. & Ishizaka, A., 2007 Nov 1, In : Japanese Journal of Chemotherapy. 55, 6, p. 451-462 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2004

Tongue metastasis as in initial presentation of a lung cancer

Terashima, T., Matsuzaki, T., Kawada, I., Nishida, J., Tanaka, Y., Morishita, T., Takeyasu, Y., Yamane, G. Y. & Uchiyama, T., 2004 Aug 1, In : Internal Medicine. 43, 8, p. 727-730 4 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2003

A case of primary lung cancer in a young female with tongue cancer

Kawada, I., Terashima, T., Morishita, T., Tanaka, Y., Kasahara, K., Yajima, Y. & Noma, H., 2003 Sep, In : Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 41, 9, p. 641-645 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2000

A case of squamous cell lung cancer in a nonsmoking female, successfully treated with docetaxel and cisplatin

Fukunaga, K., Yamaguchi, K., Kawada, I., Inoue, T., Takeshita, K., Oyamada, Y., Kameyama, K. & Yamazaki, K., 2000 Jan, In : Gan to kagaku ryoho. Cancer & chemotherapy. 27, 1, p. 139-142 4 p.

Research output: Contribution to journalArticle