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Research Output 2001 2019

  • 1090 Citations
  • 16 h-Index
  • 50 Article
  • 2 Review article
  • 1 Comment/debate
  • 1 Letter
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Article
2019

Cerebral Infarction after Transcatheter Aortic Valve Implantation in Japan: Retrospective Analysis at a Single High-Volume Center

Iizuka, T., Oki, K., Hayashida, K., Minami, K., Izawa, Y., Takahashi, S., Shimizu, H., Fukuda, K. & Nakahara, J., 2019 Jan 1, (Accepted/In press) In : Journal of Stroke and Cerebrovascular Diseases. 104455.

Research output: Contribution to journalArticle

Cerebral Infarction
Japan
Catheters
Transcatheter Aortic Valve Replacement
Carotid Stenosis
2 Citations (Scopus)

Cytometric cell-based assays for anti-striational antibodies in myasthenia gravis with myositis and/or myocarditis

Kufukihara, K., Watanabe, Y., Inagaki, T., Takamatsu, K., Nakane, S., Nakahara, J., Ando, Y. & Suzuki, S., 2019 Dec 1, In : Scientific reports. 9, 1, 5284.

Research output: Contribution to journalArticle

Open Access
Myositis
Myasthenia Gravis
Myocarditis
Connectin
Anti-Idiotypic Antibodies
4 Citations (Scopus)

Inflammatory myopathy associated with PD-1 inhibitors

Seki, M., Uruha, A., Ohnuki, Y., Kamada, S., Noda, T., Onda, A., Ohira, M., Isami, A., Hiramatsu, S., Hibino, M., Nakane, S., Noda, S., Yutani, S., Hanazono, A., Yaguchi, H., Takao, M., Shiina, T., Katsuno, M., Nakahara, J., Matsubara, S. & 2 others, Nishino, I. & Suzuki, S., 2019 Jun 1, In : Journal of Autoimmunity. 100, p. 105-113 9 p.

Research output: Contribution to journalArticle

Myositis
Muscular Diseases
Muscle Weakness
Myalgia
Signal Recognition Particle

Ropinirole Hydrochloride for ALS

Takahashi, S., Morimoto, S., Fukushima, K., Nakahara, J. & Okano, H., 2019 Nov 1, In : Brain and nerve = Shinkei kenkyu no shinpo. 71, 11, p. 1279-1288 10 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Motor Neurons
Pharmaceutical Preparations
Placebos
Clinical Trials
2 Citations (Scopus)
Open Access
Clinical Trials, Phase I
Amyotrophic Lateral Sclerosis
Labels
Placebos
Stem cells

Safety of tapering tacrolimus dose in patients with well-controlled anti-acetylcholine receptor antibody-positive myasthenia gravis

Nishida, Y., Takahashi, Y. K., Kanai, T., Nose, Y., Ishibashi, S., Sanjo, N., Uzawa, A., Oda, F., Ozawa, Y., Kuwabara, S., Noguchi, E., Suzuki, S., Nakahara, J., Suzuki, N., Ogawa, T., Yokoyama, K., Hattori, N., Konno, S., Fujioka, T., Kawaguchi, N. & 7 others, Hatanaka, Y., Sonoo, M., Kaneko, J., Ogino, M., Nishiyama, K., Nomura, K. & Yokota, T., 2019 Jan 1, (Accepted/In press) In : European Journal of Neurology.

Research output: Contribution to journalArticle

Myasthenia Gravis
Tacrolimus
Cholinergic Receptors
Safety
Antibodies
1 Citation (Scopus)

Spatiotemporal dynamics of red blood cells in capillaries in layer I of the cerebral cortex and changes in arterial diameter during cortical spreading depression and response to hypercapnia in anesthetized mice

Unekawa, M., Tomita, Y., Toriumi, H., Osada, T., Masamoto, K., Kawaguchi, H., Izawa, Y., Itoh, Y., Kanno, I., Suzuki, N. & Nakahara, J., 2019 Jan 1, In : Microcirculation. e12552.

Research output: Contribution to journalArticle

Cortical Spreading Depression
Hypercapnia
Cerebral Cortex
Erythrocytes
Cerebrovascular Circulation
1 Citation (Scopus)

Three cases of non-carryover fingolimod-PML: Is the risk in Japan increased?

Nakahara, J., Tomaske, L., Kume, K., Takata, T., Kamada, M., Deguchi, K., Kufukihara, K., Schneider, R., Gold, R. & Ayzenberg, I., 2019 May 1, In : Neurology: Neuroimmunology and NeuroInflammation. 6, 3, e559.

Research output: Contribution to journalArticle

Open Access
Progressive Multifocal Leukoencephalopathy
Japan
Immune Reconstitution Inflammatory Syndrome
IgG Deficiency
Mycoses
Myelin Sheath
Multiple Sclerosis
Visualization
Imaging techniques
Monitoring
2018
Internal Carotid Artery
Angioplasty
Carotid Arteries
Carotid Stenosis
Infarction

Clinical analysis of opticospinal multiple sclerosis (OSMS) presentation detecting anti-myelin oligodendrocyte glycoprotein (MOG) antibody

Kitagawa, S., Osada, T., Kaneko, K., Takahashi, T., Suzuki, N. & Nakahara, J., 2018 Jan 1, In : Clinical Neurology. 58, 12, p. 737-744 8 p.

Research output: Contribution to journalArticle

Myelin-Oligodendrocyte Glycoprotein
Antibodies
Spinal Cord
Oligoclonal Bands
Paresis

Continuation of axitinib for advanced renal cell carcinoma by the application of homecare urology-a case report and literature review

Yazawa, S., Kato, Y., Nakahara, J., Miyata, T. & Oya, M., 2018 Apr 1, In : Japanese Journal of Cancer and Chemotherapy. 45, 4, p. 639-642 4 p.

Research output: Contribution to journalArticle

Urology
Renal Cell Carcinoma
Valsartan
Antifoaming Agents
Medicine
15 Citations (Scopus)

Safety and efficacy of eculizumab in Guillain-Barré syndrome: a multicentre, double-blind, randomised phase 2 trial

Japanese Eculizumab Trial for GBS (JET-GBS) Study Group, 2018 Jun 1, In : The Lancet Neurology. 17, 6, p. 519-529 11 p.

Research output: Contribution to journalArticle

Safety
Placebos
Anaphylaxis
Abscess
Japan

Should multiple sclerosis be only treated by experts?

Nakahara, J., 2018 Jan 1, In : Neuro-Ophthalmology Japan. 35, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Immune System
Pharmaceutical Preparations
Demyelinating Diseases
Drug Delivery Systems
115 Citations (Scopus)

Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

EXPAND Clinical Investigators, 2018 Mar 31, In : The Lancet. 391, 10127, p. 1263-1273 11 p.

Research output: Contribution to journalArticle

Chronic Progressive Multiple Sclerosis
Placebos
1-(4-(1-((E)-4-cyclohexyl-3-trifluoromethylbenzyloxyimino)-ethyl)-2-ethylbenzyl)-azetidine-3-carboxylic acid
Bradycardia
Safety
2017
9 Citations (Scopus)

A clinical predictive score for postoperative myasthenic crisis

Kanai, T., Uzawa, A., Sato, Y., Suzuki, S., Kawaguchi, N., Himuro, K., Oda, F., Ozawa, Y., Nakahara, J., Suzuki, N., Takahashi, Y. K., Ishibashi, S., Yokota, T., Ogawa, T., Yokoyama, K., Hattori, N., Izaki, S., Oji, S., Nomura, K., Kaneko, J. & 3 others, Nishiyama, K., Yoshino, I. & Kuwabara, S., 2017 Nov 1, In : Annals of Neurology. 82, 5, p. 841-849 9 p.

Research output: Contribution to journalArticle

Muscle Weakness
Myasthenia Gravis
Thymectomy
Logistic Models
Vital Capacity
6 Citations (Scopus)
Demyelinating Diseases
Myelin Sheath
Multiple Sclerosis
Lysosphingolipid Receptors
Fingolimod Hydrochloride

Signaling Pathways Relevant to Nerve Growth Factor-induced Upregulation of Transient Receptor Potential M8 Expression

Kayama, Y., Shibata, M., Takizawa, T., Ibata, K., Nakahara, J., Shimizu, T., Toriumi, H., Yuzaki, M. & Suzuki, N., 2017 Dec 26, In : Neuroscience. 367, p. 178-188 11 p.

Research output: Contribution to journalArticle

Nerve Growth Factor
Up-Regulation
Lysosome-Associated Membrane Glycoproteins
Hyperalgesia
Proteasome Endopeptidase Complex
36 Citations (Scopus)

Skeletal muscle involvement in antisynthetase syndrome

Noguchi, E., Uruha, A., Suzuki, S., Hamanaka, K., Ohnuki, Y., Tsugawa, J., Watanabe, Y., Nakahara, J., Shiina, T., Suzuki, N. & Nishino, I., 2017 Aug 1, In : JAMA Neurology. 74, 8, p. 992-999 8 p.

Research output: Contribution to journalArticle

Myositis
Amino Acyl-tRNA Synthetases
Skeletal Muscle
Antibodies
Muscle Weakness
2016
25 Citations (Scopus)

Application of q-space diffusion MRI for the visualization of white matter

Fujiyoshi, K., Hikishima, K., Nakahara, J., Tsuji, O., Hata, J., Konomi, T., Nagai, T., Shibata, S., Kaneko, S., Iwanami, A., Momoshima, S., Takahashi, S., Jinzaki, M., Suzuki, N., Toyama, Y., Nakamura, M. & Okano, H., 2016 Mar 2, In : Journal of Neuroscience. 36, 9, p. 2796-2808 13 p.

Research output: Contribution to journalArticle

Diffusion Magnetic Resonance Imaging
Myelin Sheath
Demyelinating Diseases
Hot Temperature
White Matter
84 Citations (Scopus)

Clinical features and prognosis in anti-SRP and anti-HMGCR necrotising myopathy

Watanabe, Y., Uruha, A., Suzuki, S., Nakahara, J., Hamanaka, K., Takayama, K., Suzuki, N. & Nishino, I., 2016, In : Journal of Neurology, Neurosurgery and Psychiatry. 87, 10, p. 1038-1044 7 p.

Research output: Contribution to journalArticle

Signal Recognition Particle
Muscular Diseases
Coenzyme A
Oxidoreductases
Autoantibodies
1 Citation (Scopus)
Myelin Sheath
Central Nervous System
Magnetic Resonance Imaging

Enlargement of thymoma triggers overlapping autoimmune diseases

Shiihashi, G., Kaneko, Y., Suzuki, S., Hanaoka, H., Nakahara, J., Takeuchi, T. & Suzuki, N., 2016, (Accepted/In press) In : Autoimmunity Reviews.

Research output: Contribution to journalArticle

Thymoma
Myocarditis
Autoantibodies
Autoimmune Diseases
2 Citations (Scopus)

Enzyme-linked immunosorbent assays for diagnosis of immune-mediated necrotizing myopathy

Ikemoto, K., Suzuki, S., Uruha, A., Watanabe, Y., Nakahara, J., Nishino, I. & Suzuki, N., 2016, (Accepted/In press) In : Clinical and Experimental Neuroimmunology.

Research output: Contribution to journalArticle

Muscular Diseases
Enzyme-Linked Immunosorbent Assay
1 Citation (Scopus)

Transient receptor potential vanilloid 1-immunoreactive signals in murine enteric glial cells

Yamamoto, M., Nishiyama, M., Iizuka, S., Suzuki, S., Suzuki, N., Aiso, S. & Nakahara, J., 2016, In : World Journal of Gastroenterology. 22, 44, p. 9752-9764 13 p.

Research output: Contribution to journalArticle

Neuroglia
Myenteric Plexus
Knockout Mice
Glial Fibrillary Acidic Protein
vanilloid receptor subtype 1
2015
71 Citations (Scopus)

Inflammatory myopathy with anti-signal recognition particle antibodies: Case series of 100 patients

Suzuki, S., Nishikawa, A., Kuwana, M., Nishimura, H., Watanabe, Y., Nakahara, J., Hayashi, Y. K., Suzuki, N. & Nishino, I., 2015 May 13, In : Orphanet Journal of Rare Diseases. 10, 1, 61.

Research output: Contribution to journalArticle

Signal Recognition Particle
Myositis
Antibodies
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Muscular Diseases
1 Citation (Scopus)

Ipsilateral Facial Tactile Hypesthesia in a Patient with Lateral Medullary Syndrome

Katsumata, M., Oki, K., Nakahara, J., Izawa, Y., Abe, T., Takahashi, S. & Suzuki, N., 2015 Nov 1, In : Journal of Stroke and Cerebrovascular Diseases. 24, 11, p. e315-e317

Research output: Contribution to journalArticle

Lateral Medullary Syndrome
Hypesthesia
Touch
Neurologic Examination
Infarction

Remyelination strategy for multiple sclerosis

Nakahara, J., 2015 Sep 1, In : Nihon rinsho. Japanese journal of clinical medicine. 73, p. 854-861 8 p.

Research output: Contribution to journalArticle

Early Medical Intervention
Nerve Regeneration
Oligodendroglia
Peripheral Nervous System Diseases
Multiple Sclerosis
2014

[Emerging disease-modifying therapies for multiple sclerosis]

Nakahara, J., 2014 Nov 1, In : Nihon rinsho. Japanese journal of clinical medicine. 72, 11, p. 2031-2037 7 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Therapeutics
Demyelinating Diseases
Gait
Interferons
1 Citation (Scopus)

Natalizumab: An antibody targeting α4-Integrin

Nakahara, J., 2014 Oct 1, In : Brain and Nerve. 66, 10, p. 1149-1158 10 p.

Research output: Contribution to journalArticle

Integrins
Multiple Sclerosis
Central Nervous System
Antibodies
Cell Adhesion Molecules

Pathogenesis of cognitive impairment in multiple sclerosis

Nakahara, J., 2014, In : Clinical Neurology. 54, 12, p. 1063-1065 3 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Cognitive Reserve
Demyelinating Diseases
Atrophy
Smoking
2013

Does neuroinflammation induce systemic aging?

Nakahara, J., 2013 Aug, In : Clinical and Experimental Neuroimmunology. 4, 2, p. 155-156 2 p.

Research output: Contribution to journalArticle

Hypothalamus
Gonadotropin-Releasing Hormone
Hormones
Inflammation
2012
62 Citations (Scopus)

Current concepts in multiple sclerosis: Autoimmunity versus oligodendrogliopathy

Nakahara, J., Maeda, M., Aiso, S. & Suzuki, N., 2012 Feb, In : Clinical Reviews in Allergy and Immunology. 42, 1, p. 26-34 9 p.

Research output: Contribution to journalArticle

Autoimmunity
Multiple Sclerosis
Demyelinating Diseases
Therapeutics
Recurrence

Novel remyelination strategy for multiple sclerosis in the era of oligodendrocytopathy

Nakahara, J., 2012, In : Clinical Neurology. 52, 11, p. 1351-1353 3 p.

Research output: Contribution to journalArticle

Oligodendroglia
Multiple Sclerosis
Cell Nucleus Active Transport
Protein Transport
Cell Differentiation
2010
10 Citations (Scopus)

Autoimmune versus oligodendrogliopathy: The pathogenesis of multiple sclerosis

Nakahara, J., Aiso, S. & Suzuki, N., 2010 Oct, In : Archivum Immunologiae et Therapiae Experimentalis. 58, 5, p. 325-333 9 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Demyelinating Diseases
Central Nervous System
Myelin Sheath
Autoimmunity

Blueprint for the development of remyelination medicines for multiple sclerosis

Nakahara, J., 2010, In : Clinical Neurology. 50, 11, p. 870 1 p.

Research output: Contribution to journalArticle

Molecular Targeted Therapy
IgG Receptors
Nerve Regeneration
Acetyltransferases
Oligodendroglia
2009
77 Citations (Scopus)

Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis

Nakahara, J., Kanekura, K., Nawa, M., Aiso, S. & Suzuki, N., 2009 Jan 5, In : Journal of Clinical Investigation. 119, 1, p. 169-181 13 p.

Research output: Contribution to journalArticle

Contactins
Cell Nucleus Active Transport
Oligodendroglia
Multiple Sclerosis
Axons
11 Citations (Scopus)

A new monoclonal antibody, A3B10, specific for astrocyte-lineage cells recognizes calmodulin-regulated spectrin-associated protein 1 (Camsap1)

Yamamoto, M., Yoshimura, K., Kitada, M., Nakahara, J., Seiwa, C., Ueki, T., Shimoda, Y., Ishige, A., Watanabe, K. & Asou, H., 2009 Feb 1, In : Journal of Neuroscience Research. 87, 2, p. 503-513 11 p.

Research output: Contribution to journalArticle

Spectrin
Calmodulin
Astrocytes
Monoclonal Antibodies
Glial Fibrillary Acidic Protein
10 Citations (Scopus)

Factors that retard remyelination in multiple sclerosis with a focus on TIP30: A novel therapeutic target

Nakahara, J., Aiso, S. & Suzuki, N., 2009 Dec, In : Expert Opinion on Therapeutic Targets. 13, 12, p. 1375-1386 12 p.

Research output: Contribution to journalArticle

Oligodendroglia
Multiple Sclerosis
Recovery
Pathology
Cell death
2006
14 Citations (Scopus)

Fc receptor-positive cells in remyelinating multiple sclerosis lesions

Nakahara, J. & Aiso, S., 2006 Jun, In : Journal of Neuropathology and Experimental Neurology. 65, 6, p. 582-591 10 p.

Research output: Contribution to journalArticle

Fc Receptors
Oligodendroglia
Multiple Sclerosis
Microglia
Immunoglobulin Subunits
25 Citations (Scopus)

Fulminant Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disorder with hemophagocytosis following autologous peripheral blood stem cell transplantation for relapsed angioimmunoblastic T-cell lymphoma

Awaya, N., Adachi, A., Mori, T., Kamata, H., Nakahara, J., Yokoyama, K., Yamada, T., Kizaki, M., Sakamoto, M., Ikeda, Y. & Okamoto, S., 2006 Aug, In : Leukemia Research. 30, 8, p. 1059-1062 4 p.

Research output: Contribution to journalArticle

Peripheral Blood Stem Cell Transplantation
Lymphoproliferative Disorders
T-Cell Lymphoma
Human Herpesvirus 4
Hematopoietic Stem Cell Transplantation
2005
22 Citations (Scopus)

Involvement of CD45 in central nervous system myelination

Nakahara, J., Seiwa, C., Tan-Takeuchi, K., Gotoh, M., Kishihara, K., Ogawa, M., Asou, H. & Aiso, S., 2005 May 6, In : Neuroscience Letters. 379, 2, p. 116-121 6 p.

Research output: Contribution to journalArticle

Oligodendroglia
Central Nervous System
Proto-Oncogene Proteins c-fyn
Myelin Sheath
Protein Tyrosine Phosphatases
2004
63 Citations (Scopus)

Bisphenol A exerts thyroid-hormone-like effects on mouse oligodendrocyte precursor cells

Seiwa, C., Nakahara, J., Komiyama, T., Katsu, Y., Iguchi, T. & Asou, H., 2004, In : Neuroendocrinology. 80, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

Oligodendroglia
Thyroid Hormones
Myelin Basic Protein
Cell Differentiation
Protein Isoforms
38 Citations (Scopus)

Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice

Kawasumi, M., Chiba, T., Yamada, M., Miyamae-Kaneko, M., Matsuoka, M., Nakahara, J., Tomita, T., Iwatsubo, T., Kato, S., Aiso, S., Nishimoto, I. & Koyama, K., 2004 May, In : European Journal of Neuroscience. 19, 10, p. 2826-2838 13 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Alzheimer Disease
Mutation
Genes
Short-Term Memory
2003
18 Citations (Scopus)

Expression of Fc receptor for immunoglobulin M in oligodendrocytes and myelin of mouse central nervous system

Nakahara, J., Seiwa, C., Shibuya, A., Aiso, S. & Asou, H., 2003 Feb 6, In : Neuroscience Letters. 337, 2, p. 73-76 4 p.

Research output: Contribution to journalArticle

Immunoglobulin Fc Fragments
Fc Receptors
Oligodendroglia
Myelin Sheath
Immunoglobulin M
258 Citations (Scopus)

Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice

Kaifu, T., Nakahara, J., Inui, M., Mishima, K., Momiyama, T., Kaji, M., Sugahara, A., Koito, H., Ujike-Asai, A., Nakamura, A., Kanazawa, K., Tan-Takeuchi, K., Iwasaki, K., Yokoyama, W. M., Kudo, A., Fujiwara, M., Asou, H. & Takai, T., 2003 Feb, In : Journal of Clinical Investigation. 111, 3, p. 323-332 10 p.

Research output: Contribution to journalArticle

Osteopetrosis
Thalamus
Schizophrenia
Oligodendroglia
Osteoclasts
17 Citations (Scopus)

Role of radial fibers in controlling the onset of myelination

Nakahara, J., Takemura, M., Gomi, H., Tsunematsu, K. I., Itohara, S., Asou, H., Ogawa, M., Aiso, S. & Tan-Takeuchi, K., 2003 May 1, In : Journal of Neuroscience Research. 72, 3, p. 279-289 11 p.

Research output: Contribution to journalArticle

Glial Fibrillary Acidic Protein
Astrocytes
Axons
Oligodendroglia
Lateral Ventricles
51 Citations (Scopus)

Signaling via immunoglobulin Fc receptors induces oligodendrocyte precursor cell differentiation

Nakahara, J., Tan-Takeuchi, K., Seiwa, C., Gotoh, M., Kaifu, T., Ujike, A., Inui, M., Yagi, T., Ogawa, M., Aiso, S., Takai, T. & Asou, H., 2003 Jun 1, In : Developmental Cell. 4, 6, p. 841-852 12 p.

Research output: Contribution to journalArticle

Fc Receptors
Oligodendroglia
Myelin Basic Protein
Immunoglobulins
Cell Differentiation

The mechanism of central nervous system myelination

Nakahara, J. & Asou, H., 2003 May, In : Seikagaku. The Journal of Japanese Biochemical Society. 75, 5, p. 395-399 5 p.

Research output: Contribution to journalArticle

2001
12 Citations (Scopus)

Myelin basic protein is necessary for the regulation of myelin-associated glycoprotein expression in mouse oligodendroglia

Nakahara, J., Tan-Takeuchi, K., Seiwa, C., Yagi, T., Aiso, S., Kawamura, K. & Asou, H., 2001 Feb 9, In : Neuroscience Letters. 298, 3, p. 163-166 4 p.

Research output: Contribution to journalArticle

Myelin-Associated Glycoprotein
Myelin Basic Protein
Oligodendroglia
Protein Deficiency
Neuroglia