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Research Output

  • 316 Citations
  • 11 h-Index
  • 20 Article
  • 4 Review article
  • 2 Editorial
2020

Association of glomerular DNA damage and DNA methylation with one-year eGFR decline in IgA nephropathy

Hayashi, K., Hishikawa, A., Hashiguchi, A., Azegami, T., Yoshimoto, N., Nakamichi, R., Tokuyama, H. & Itoh, H., 2020 Dec 1, In : Scientific reports. 10, 1, 237.

Research output: Contribution to journalArticle

Open Access

DNA damage and expression of DNA methylation modulators in urine-derived cells of patients with hypertension and diabetes

Hishikawa, A., Hayashi, K., Yoshimoto, N., Nakamichi, R., Homma, K. & Itoh, H., 2020 Feb 25, In : Scientific reports. 10, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
2019

Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes

Hishikawa, A., Hayashi, K., Abe, T., Kaneko, M., Yokoi, H., Azegami, T., Nakamura, M., Yoshimoto, N., Kanda, T., Sakamaki, Y. & Itoh, H., 2019 Jan 29, In : Cell Reports. 26, 5, p. 1318-1332.e4

Research output: Contribution to journalArticle

2 Citations (Scopus)

DNA Damage Repair and DNA Methylation in the Kidney

Hayashi, K., Hishikawa, A. & Itoh, H., 2019 Jul 1, In : American Journal of Nephrology. 50, 2, p. 81-91 11 p.

Research output: Contribution to journalReview article

Open Access
3 Citations (Scopus)
2018

Intranasal vaccination against angiotensin II type 1 receptor and pneumococcal surface protein A attenuates hypertension and pneumococcal infection in rodents

Azegami, T., Yuki, Y., Hayashi, K., Hishikawa, A., Sawada, S. I., Ishige, K., Akiyoshi, K., Kiyono, H. & Itoh, H., 2018 Feb 1, In : Journal of Hypertension. 36, 2, p. 387-394 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Pre-emptive medicine for hypertension and its prospects

Itoh, H., Hayashi, K. & Miyashita, K., 2018 Jan 1, (Accepted/In press) In : Hypertension Research.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Transcription factors as therapeutic targets in chronic kidney disease

Hishikawa, A., Hayashi, K. & Itoh, H., 2018 Jan 1, In : Molecules. 23, 5, 1123.

Research output: Contribution to journalReview article

6 Citations (Scopus)
2017
3 Citations (Scopus)
8 Citations (Scopus)
2016

DNA damage and epigenetic changes in kidney diseases - Focused on transcription factors in podocytes

Hayashi, K., Hishikawa, A. & Itoh, H., 2016 Aug 1, In : Current Medical Imaging Reviews. 12, 2, p. 105-111 7 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Epigenetic modulations in kidney podocytes: A possible target of treatment for proteinuria

Hayashi, K., 2016 Aug 1, In : Current Medical Imaging Reviews. 12, 2, p. 88 1 p.

Research output: Contribution to journalEditorial

2015

Renin-angiotensin blockade resets podocyte epigenome through Kruppel-like Factor 4 and attenuates proteinuria

Hayashi, K., Sasamura, H., Nakamura, M., Sakamaki, Y., Azegami, T., Oguchi, H., Tokuyama, H., Wakino, S., Hayashi, K. & Itoh, H., 2015 Oct 3, In : Kidney international. 88, 4, p. 745-753 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2014

KLF4-dependent epigenetic remodeling modulates podocyte phenotypes and attenuates proteinuria

Hayashi, K., Sasamura, H., Nakamura, M., Azegami, T., Oguchi, H., Sakamaki, Y. & Itoh, H., 2014 Jun 2, In : Journal of Clinical Investigation. 124, 6, p. 2523-2537 15 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Renal arteriolar injury by salt intake contributes to salt memory for the development of hypertension

Oguchi, H., Sasamura, H., Shinoda, K., Morita, S., Kono, H., Nakagawa, K., Ishiguro, K., Hayashi, K., Nakamura, M., Azegami, T., Oya, M. & Itoh, H., 2014 Jan 1, In : Hypertension. 64, 4, p. 784-791 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
5 Citations (Scopus)
2012
15 Citations (Scopus)

Vaccination against the angiotensin type 1 receptor for the prevention of L-NAME-induced nephropathy

Azegami, T., Sasamura, H., Hayashi, K. & Itoh, H., 2012 May 1, In : Hypertension Research. 35, 5, p. 492-499 8 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2011

Use of serum and urine metabolome analysis for the detection of metabolic changes in patients with stage 1-2 chronic kidney disease

Hayashi, K., Sasamura, H., Hishiki, T., Suematsu, M., Ikeda, S., Soga, T. & Itoh, H., 2011 Jan 1, In : Nephro-Urology Monthly. 3, 3, p. 164-171 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2010

Absence of gelatinase (MMP-9) or collagenase (MMP-13) attenuates adriamycin-Induced albuminuria and glomerulosclerosis

Sakamaki, Y., Sasamura, H., Hayashi, K., Ishiguro, K., Takaishi, H., Okada, Y., D'Armiento, J. M., Saruta, T. & Itoh, H., 2010 Jun 1, In : Nephron - Experimental Nephrology. 115, 2, p. e22-e32

Research output: Contribution to journalArticle

14 Citations (Scopus)

Regression of glomerulosclerosis in response to transient treatment with angiotensin II blockers is attenuated by blockade of matrix metalloproteinase-2

Hayashi, K., Sasamura, H., Ishiguro, K., Sakamaki, Y., Azegami, T. & Itoh, H., 2010 Jul 1, In : Kidney international. 78, 1, p. 69-78 10 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
2009

Activation of dendritic-like cells and neural stem/progenitor cells in injured spinal cord by GM-CSF

Hayashi, K., Ohta, S., Kawakami, Y. & Toda, M., 2009 May 1, In : Neuroscience Research. 64, 1, p. 96-103 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Prevention and regression of hypertension: Role of renal microvascular protection

Sasamura, H., Hayashi, K., Ishiguro, K., Nakaya, H., Saruta, T. & Itoh, H., 2009 Aug 13, In : Hypertension Research. 32, 8, p. 658-664 7 p.

Research output: Contribution to journalReview article

15 Citations (Scopus)

"Pulse" treatment with high-dose angiotensin blocker reverses renal arteriolar hypertrophy and regresses hypertension

Ishiguro, K., Hayashi, K., Sasamura, H., Sakamaki, Y. & Itoh, H., 2009 Jan 1, In : Hypertension. 53, 1, p. 83-89 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2008
7 Citations (Scopus)