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Research Output 1990 2019

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2019

Both excitatory and inhibitory neurons transiently form clusters at the outermost region of the developing mammalian cerebral neocortex

Shin, M., Kitazawa, A., Yoshinaga, S., Hayashi, K., Hirata, Y., Dehay, C., Kubo, K. & Nakajima, K., 2019 Jan 1, In : Journal of Comparative Neurology.

Research output: Contribution to journalArticle

Neocortex
Neurons
Interneurons
Primates
Occipital Lobe
2 Citations (Scopus)

Drebrin-like (Dbnl) controls neuronal migration via regulating N-cadherin expression in the developing cerebral cortex

Inoue, S., Hayashi, K., Fujita, K., Tagawa, K., Okazawa, H., Kubo, K. & Nakajima, K., 2019 Jan 23, In : Journal of Neuroscience. 39, 4, p. 678-691 14 p.

Research output: Contribution to journalArticle

Cadherins
Cerebral Cortex
Neurons
Actin Cytoskeleton
Time-Lapse Imaging
2018
6 Citations (Scopus)

ApoER2 Controls not only neuronal migration in the intermediate zone but also termination of migration in the developing cerebral cortex

Hirota, Y., Kubo, K., Fujino, T., Yamamoto, T. T. & Nakajima, K., 2018 Jan 1, In : Cerebral Cortex. 28, 1, p. 223-235 13 p.

Research output: Contribution to journalArticle

Cerebral Cortex
Neurons
Neocortex
Brain
Integrins
2017

A crossroad of neuronal diversity to build circuitry

Yoshinaga, S. & Nakajima, K., 2017 Apr 28, In : Science. 356, 6336, p. 376-377 2 p.

Research output: Contribution to journalArticle

cells and cell components
Nerve Net
genetic analysis
rodent
brain
5 Citations (Scopus)

Association of impaired neuronal migration with cognitive deficits in extremely preterm infants

Kubo, K., Deguchi, K., Nagai, T., Ito, Y., Yoshida, K., Endo, T., Benner, S., Shan, W., Kitazawa, A., Aramaki, M., Ishii, K., Shin, M., Matsunaga, Y., Hayashi, K., Kakeyama, M., Tohyama, C., Tanaka, K., Tanaka, K., Takashima, S., Nakayama, M. & 7 others, Itoh, M., Hirata, Y., Antalffy, B., Armstrong, D. D., Yamada, K., Inoue, K. & Nakajima, K., 2017 May 18, In : JCI insight. 2, 10

Research output: Contribution to journalArticle

Open Access
Extremely Premature Infants
Brain Injuries
Neocortex
Neurons
Uterine Artery
15 Citations (Scopus)

CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations

Okuno, H., Mihara, F. R., Ota, S., Fukuda, K., Kurosawa, K., Akamatsu, W., Sanosaka, T., Kohyama, J., Hayashi, K., Nakajima, K., Takahashi, T., Wysocka, J., Kosaki, K. & Okano, H., 2017 Nov 28, In : eLife. 6, e21114.

Research output: Contribution to journalArticle

CHARGE Syndrome
Induced Pluripotent Stem Cells
Neural Crest
Stem cells
Mutation
5 Citations (Scopus)

Dendritic Homeostasis Disruption in a Novel Frontotemporal Dementia Mouse Model Expressing Cytoplasmic Fused in Sarcoma

Shiihashi, G., Ito, D., Arai, I., Kobayashi, Y., Hayashi, K., Otsuka, S., Nakajima, K., Yuzaki, M., Itohara, S. & Suzuki, N., 2017, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Frontotemporal Dementia
Sarcoma
Homeostasis
Messenger RNA
Brain

Enhanced expression of Pafah1b1 causes over-migration of cerebral cortical neurons into the marginal zone

Katayama, K. I., Hayashi, K., Inoue, S., Sakaguchi, K. & Nakajima, K., 2017 Aug 23, (Accepted/In press) In : Brain Structure and Function. p. 1-9 9 p.

Research output: Contribution to journalArticle

Neurons
Lissencephaly
Electroporation
Brain
Nervous System Diseases
4 Citations (Scopus)

Impaired dendritic growth and positioning of cortical pyramidal neurons by activation of aryl hydrocarbon receptor signaling in the developing mouse

Kimura, E., Kubo, K., Endo, T., Ling, W., Nakajima, K., Kakeyama, M. & Tohyama, C., 2017 Aug 1, In : PLoS One. 12, 8, e0183497.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Pyramidal Cells
Neurons
hydrocarbons
neurons
13 Citations (Scopus)

Reelin transiently promotes N-cadherin-dependent neuronal adhesion during mouse cortical development

Matsunaga, Y., Noda, M., Murakawa, H., Hayashi, K., Nagasaka, A., Inoue, S., Miyata, T., Miura, T., Kubo, K. & Nakajima, K., 2017 Feb 21, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 8, p. 2048-2053 6 p.

Research output: Contribution to journalArticle

Cadherins
Neurons
Ependymoglial Cells
Adhesiveness
Neocortex
1 Citation (Scopus)

Subtype Specification of Cerebral Cortical Neurons in Their Immature Stages

Oishi, K. & Nakajima, K., 2017 Nov 28, (Accepted/In press) In : Neurochemical Research. p. 1-7 7 p.

Research output: Contribution to journalArticle

Neurons
Specifications
Cues
Plasticity
Axons
2016
15 Citations (Scopus)

ADP ribosylation factor 6 regulates neuronal migration in the developing cerebral cortex through FIP3/arfophilin-1-dependent endosomal trafficking of N-cadherin

Hara, Y., Fukaya, M., Hayashi, K., Kawauchi, T., Nakajima, K. & Sakagami, H., 2016, In : eNeuro. 3, 4, e0148-16.2016.

Research output: Contribution to journalArticle

Cadherins
Cerebral Cortex
Proteins
Neurons
Membrane Transport Proteins
16 Citations (Scopus)

Identity of neocortical layer 4 neurons is specified through correct positioning into the cortex

Oishi, K., Nakagawa, N., Tachikawa, K., Sasaki, S., Aramaki, M., Hirano, S., Yamamoto, N., Yoshimura, Y. & Nakajima, K., 2016 Feb 12, In : eLife. 5, FEBRUARY2016, e10907.

Research output: Contribution to journalArticle

Neurons
Specifications
Cytoskeletal Proteins
Neocortex
Restoration
4 Citations (Scopus)

In utero bisphenol A exposure induces abnormal neuronal migration in the cerebral cortex of mice

Ling, W., Endo, T., Kubo, K., Nakajima, K., Kakeyama, M. & Tohyama, C., 2016, In : Frontiers in Endocrinology. 7, FEB, 7.

Research output: Contribution to journalArticle

Cerebral Cortex
Electroporation
bisphenol A
Brain
Laboratory Animals
14 Citations (Scopus)
Cerebral Cortex
Brain
Neurons
Neocortex
Transcription Factors
19 Citations (Scopus)

PDK1-Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex

Itoh, Y., Higuchi, M., Oishi, K., Kishi, Y., Okazaki, T., Sakai, H., Miyata, T., Nakajima, K. & Gotoh, Y., 2016 May 24, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 21, p. E2955-E2964

Research output: Contribution to journalArticle

Neocortex
Phosphatidylinositols
Microtubules
Protein Kinases
Locomotion
9 Citations (Scopus)
Cytoplasm
Nuclear Export Signals
Neurons
Nuclear Localization Signals
Electroporation
1 Citation (Scopus)

The mitotic tensegrity guardian tau protects mammary epithelia from katanin-like1-induced aneuploidy

Sudo, H. & Nakajima, K., 2016 Aug 1, In : Oncotarget. 7, 33, p. 53712-53734 23 p.

Research output: Contribution to journalArticle

Aneuploidy
Microtubules
Breast
Epithelium
Carcinogenesis
2015
3 Citations (Scopus)

Analysis of cardiomyocyte movement in the developing murine heart

Hashimoto, H., Yuasa, S., Tabata, H., Tohyama, S., Seki, T., Egashira, T., Hayashiji, N., Hattori, F., Kusumoto, D., Kunitomi, A., Takei, M., Kashimura, S., Yozu, G., Shimojima, M., Motoda, C., Muraoka, N., Nakajima, K., Sakaue-Sawano, A., Miyawaki, A. & Fukuda, K., 2015 Jun 26, In : Biochemical and Biophysical Research Communications. 464, 4, p. 1000-1007 8 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Cell Cycle
Cells
Ubiquitination
Time-Lapse Imaging
15 Citations (Scopus)

Cdk5 phosphorylation of ErbB4 is required for tangential migration of cortical interneurons

Rakić, S., Kanatani, S., Hunt, D., Faux, C., Cariboni, A., Chiara, F., Khan, S., Wansbury, O., Howard, B., Nakajima, K., Nikolić, M. & Parnavelas, J. G., 2015 Apr 1, In : Cerebral Cortex. 25, 4, p. 991-1003 13 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 5
Interneurons
Phosphorylation
Schizophrenia
Phosphatidylinositol 3-Kinase
15 Citations (Scopus)

Cellular dynamics of neuronal migration in the hippocampus

Hayashi, K., Kubo, K., Kitazawa, A. & Nakajima, K., 2015, In : Frontiers in Neuroscience. 9, APR, 135.

Research output: Contribution to journalArticle

Hippocampus
Neurons
Pyramidal Cells
Rodentia
Psychiatry
73 Citations (Scopus)

Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS

Yamakawa, M., Ito, D., Honda, T., Kubo, K., Noda, M., Nakajima, K. & Suzuki, N., 2015, In : Human Molecular Genetics. 24, 6, p. 1630-1645 16 p., ddu576.

Research output: Contribution to journalArticle

Dipeptides
Amyotrophic Lateral Sclerosis
Glycine
Ubiquitin
Proline
16 Citations (Scopus)

Developmental origin of abnormal dendritic growth in the mouse brain induced by in utero disruption of aryl hydrocarbon receptor signaling

Kimura, E., Kubo, K., Matsuyoshi, C., Benner, S., Hosokawa, M., Endo, T., Ling, W., Kohda, M., Yokoyama, K., Nakajima, K., Kakeyama, M. & Tohyama, C., 2015 Nov 1, In : Neurotoxicology and Teratology. 52, p. 42-50 9 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Brain
Hippocampus
Dioxins
Growth
31 Citations (Scopus)

Importance of reelin C-terminal region in the development and maintenance of the postnatal cerebral cortex and its regulation by specific proteolysis

Kohno, T., Honda, T., Kubo, K., Nakano, Y., Tsuchiya, A., Murakami, T., Banno, H., Nakajima, K. & Hattori, M., 2015, In : Journal of Neuroscience. 35, 11, p. 4776-4787 12 p.

Research output: Contribution to journalArticle

Cerebral Cortex
Proteolysis
Maintenance
Dendrites
Phosphorylation
18 Citations (Scopus)

Neuronal heterotopias affect the activities of distant brain areas and lead to behavioral deficits

Ishii, K., Kubo, K., Endo, T., Yoshida, K., Benner, S., Ito, Y., Aizawa, H., Aramaki, M., Yamanaka, A., Tanaka, K., Takata, N., Tanaka, K., Mimura, M., Tohyama, C., Kakeyama, M. & Nakajima, K., 2015 Sep 9, In : Journal of Neuroscience. 35, 36, p. 12432-12445 14 p.

Research output: Contribution to journalArticle

Prefrontal Cortex
Memory Disorders
Short-Term Memory
Brain
Competitive Behavior
12 Citations (Scopus)

Reelin has a preventive effect on phencyclidine-induced cognitive and sensory-motor gating deficits

Ishii, K., Nagai, T., Hirota, Y., Noda, M., Nabeshima, T., Yamada, K., Kubo, K. & Nakajima, K., 2015 Jul 1, In : Neuroscience Research. 96, p. 30-36 7 p.

Research output: Contribution to journalArticle

Sensory Gating
Phencyclidine
Prefrontal Cortex
GABAergic Neurons
Lateral Ventricles
30 Citations (Scopus)

Reelin receptors ApoER2 and VLDLR are expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex

Hirota, Y., Kubo, K., Katayama, K. I., Honda, T., Fujino, T., Yamamoto, T. T. & Nakajima, K., 2015 Feb 15, In : Journal of Comparative Neurology. 523, 3, p. 463-478 16 p.

Research output: Contribution to journalArticle

Cerebral Cortex
Neurons
Neocortex
Glycoproteins
Monoclonal Antibodies
12 Citations (Scopus)

The COUP-TFII/neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain

Kanatani, S., Honda, T., Aramaki, M., Hayashi, K., Kubo, K., Ishida, M., Tanaka, D. H., Kawauchi, T., Sekine, K., Kusuzawa, S., Kawasaki, T., Hirata, T., Tabata, H., Uhlén, P. & Nakajima, K., 2015 Sep 8, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 36, p. E4985-E4994

Research output: Contribution to journalArticle

COUP Transcription Factor II
Neuropilin-2
GABAergic Neurons
Diencephalon
Preoptic Area
2014
26 Citations (Scopus)

Cdk5 and its substrates, Dcx and p27kip1, regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons

Nishimura, Y. V., Shikanai, M., Hoshino, M., Ohshima, T., Nabeshima, Y. I., Mizutani, K. I., Nagata, K. I., Nakajima, K. & Kawauchi, T., 2014, In : Development (Cambridge). 141, 18, p. 3540-3550 11 p.

Research output: Contribution to journalArticle

Dilatation
Neurons
Microtubules
Cerebral Cortex
Cyclin-Dependent Kinases
29 Citations (Scopus)

Hippocampal pyramidal neurons switch from a multipolar migration mode to a novel "climbing" migration mode during development

Kitazawa, A., Kubo, K., Hayashi, K., Matsunaga, Y., Ishii, K. & Nakajima, K., 2014, In : Journal of Neuroscience. 34, 4, p. 1115-1126 12 p.

Research output: Contribution to journalArticle

Pyramidal Cells
Hippocampus
Neocortex
Neurons
Time-Lapse Imaging
61 Citations (Scopus)

How does Reelin control neuronal migration and layer formation in the developing mammalian neocortex?

Sekine, K., Kubo, K. & Nakajima, K., 2014 Sep 1, In : Neuroscience Research. 86, p. 50-58 9 p.

Research output: Contribution to journalArticle

Neocortex
Parturition
Neurons
Adhesiveness
Cell Polarity
15 Citations (Scopus)

Time-lapse imaging of cell cycle dynamics during development in living cardiomyocyte

Hashimoto, H., Yuasa, S., Tabata, H., Tohyama, S., Hayashiji, N., Hattori, F., Muraoka, N., Egashira, T., Okata, S., Yae, K., Seki, T., Nishiyama, T., Nakajima, K., Sakaue-Sawano, A., Miyawaki, A. & Fukuda, K., 2014, In : Journal of Molecular and Cellular Cardiology. 72, p. 241-249 9 p.

Research output: Contribution to journalArticle

Time-Lapse Imaging
Cardiac Myocytes
Cell Cycle
G2 Phase
Ubiquitination
2013

[Results of a questionnaire on efforts to increase research-oriented doctors].

Yaginuma, H., Matsumura, G., Mori, C., Maeda, T., Araki, N., Noda, Y., Nakajima, K., Kawata, M., Okabe, S. & working group for the future planning of the Japanese Association of Anatomists, G. F. T. F. P. O. T. J. A. O. A., 2013 Mar, In : Kaibogaku zasshi. Journal of anatomy. 88, 1-2, p. 3-8 6 p.

Research output: Contribution to journalArticle

Students
Research
Curriculum
Financial Support
Dental Schools
15 Citations (Scopus)

Axon guidance mechanisms for establishment of callosal connections

Nishikimi, M., Oishi, K. & Nakajima, K., 2013, In : Neural Plasticity. 2013, 149060.

Research output: Contribution to journalArticle

Corpus Callosum
Axons
Cues
Agenesis of Corpus Callosum
Neurons
5 Citations (Scopus)

Dab1-mediated colocalization of multi-adaptor protein CIN85 with Reelin receptors, ApoER2 and VLDLR, in neurons

Fuchigami, T., Sato, Y., Tomita, Y., Takano, T., Miyauchi, S. Y., Tsuchiya, Y., Saito, T., Kubo, K., Nakajima, K., Fukuda, M., Hattori, M. & Hisanaga, S. I., 2013 May, In : Genes to Cells. 18, 5, p. 410-424 15 p.

Research output: Contribution to journalArticle

Neurons
Phosphorylation
Proteins
Endosomes
Receptor Protein-Tyrosine Kinases
25 Citations (Scopus)

DISC1: A key lead in studying cortical development and associated brain disorders

Narayan, S., Nakajima, K. & Sawa, A., 2013 Oct, In : Neuroscientist. 19, 5, p. 451-464 14 p.

Research output: Contribution to journalArticle

Brain Diseases
Schizophrenia
Research
Lead
Therapeutics
2 Citations (Scopus)

Neuronal distribution in the cerebral cortex and its significance in schizophrenia

Kubo, K. & Nakajima, K., 2013 Oct, In : Brain and Nerve. 65, 10, p. 1133-1145 13 p.

Research output: Contribution to journalArticle

Cerebral Cortex
Schizophrenia
Neocortex
Brain
Psychotic Disorders
16 Citations (Scopus)

Robo1 regulates the migration and laminar distribution of upper-layer pyramidal neurons of the cerebral cortex

Gonda, Y., Andrews, W. D., Tabata, H., Namba, T., Parnavelas, J. G., Nakajima, K., Kohsaka, S., Hanashima, C. & Uchino, S., 2013 Jun, In : Cerebral Cortex. 23, 6, p. 1495-1508 14 p.

Research output: Contribution to journalArticle

Pyramidal Cells
Cerebral Cortex
Neurons
Electroporation
Neocortex
44 Citations (Scopus)

RP58 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Cerebral Cortex

Ohtaka-Maruyama, C., Hirai, S., Miwa, A., Heng, J. I. T., Shitara, H., Ishii, R., Taya, C., Kawano, H., Kasai, M., Nakajima, K. & Okado, H., 2013, In : Cell Reports. 3, 2, p. 458-471 14 p.

Research output: Contribution to journalArticle

Cerebral Cortex
Neurons
Defects
Electroporation
Brain
7 Citations (Scopus)
Lateral Ventricles
Primates
Pressure
Population
Genes
45 Citations (Scopus)

TAG-1-assisted progenitor elongation streamlines nuclear migration to optimize subapical crowding

Okamoto, M., Namba, T., Shinoda, T., Kondo, T., Watanabe, T., Inoue, Y., Takeuchi, K., Enomoto, Y., Ota, K., Oda, K., Wada, Y., Sagou, K., Saito, K., Sakakibara, A., Kawaguchi, A., Nakajima, K., Adachi, T., Fujimori, T., Ueda, M., Hayashi, S. & 2 others, Kaibuchi, K. & Miyata, T., 2013 Nov, In : Nature Neuroscience. 16, 11, p. 1556-1566 11 p.

Research output: Contribution to journalArticle

Mechanical Stress
Carisoprodol
Cell Cycle
Stem Cells
Neurons
2012
24 Citations (Scopus)

A phosphatidylinositol lipids system, lamellipodin, and Ena/VASP regulate dynamic morphology of multipolar migrating cells in the developing cerebral cortex

Yoshinaga, S., Ohkubo, T., Sasaki, S., Nuriya, M., Ogawa, Y., Yasui, M., Tabata, H. & Nakajima, K., 2012 Aug 22, In : Journal of Neuroscience. 32, 34, p. 11643-11656 14 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Cerebral Cortex
Lipids
Pseudopodia
Neurons
11 Citations (Scopus)

Cortical excitatory neurons become protected from cell division during neurogenesis in an RB family-dependent manner

Oshikawa, M., Okada, K., Nakajima, K. & Ajioka, I., 2012 Jun 1, In : Development (Cambridge). 140, 11, p. 2310-2320 11 p.

Research output: Contribution to journalArticle

Neurogenesis
Cell Division
Neurons
S Phase
DNA Damage
34 Citations (Scopus)

Cytoarchitecture of mouse and human subventricular zone in developing cerebral neocortex

Tabata, H., Yoshinaga, S. & Nakajima, K., 2012 Jan, In : Experimental Brain Research. 216, 2, p. 161-168 8 p.

Research output: Contribution to journalArticle

Lateral Ventricles
Neocortex
Stem Cells
Neurons
Ependymoglial Cells
11 Citations (Scopus)

GABAergic interneuron migration and the evolution of the neocortex

Tanaka, D. H. & Nakajima, K., 2012 Apr, In : Development Growth and Differentiation. 54, 3, p. 366-372 7 p.

Research output: Contribution to journalArticle

Neocortex
Interneurons
Mammals
Vertebrates
Neurons
18 Citations (Scopus)

Involvement of metabotropic glutamate receptor 5 signaling in activity-related proliferation of adult hippocampal neural stem cells

Nochi, R., Kato, T., Kaneko, J., Itou, Y., Kuribayashi, H., Fukuda, S., Terazono, Y., Matani, A., Kanatani, S., Nakajima, K. & Hisatsune, T., 2012 Aug, In : European Journal of Neuroscience. 36, 3, p. 2273-2283 11 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate 5 Receptor
Neural Stem Cells
Middle Cerebral Artery Infarction
Excitatory Amino Acid Antagonists
Metabotropic Glutamate Receptors
10 Citations (Scopus)
Nuclear Localization Signals
Leucine
Glioma
Epilepsy
Cytoplasm
25 Citations (Scopus)

Migratory pathways of GABAergic interneurons when they enter the neocortex

Tanaka, D. H. & Nakajima, K., 2012 Jun, In : European Journal of Neuroscience. 35, 11, p. 1655-1660 6 p.

Research output: Contribution to journalArticle

Neocortex
Interneurons
gamma-Aminobutyric Acid
Rodentia
Brain
91 Citations (Scopus)

Reelin Controls Neuronal Positioning by Promoting Cell-Matrix Adhesion via Inside-Out Activation of Integrin α5β1

Sekine, K., Kawauchi, T., Kubo, K., Honda, T., Herz, J., Hattori, M., Kinashi, T. & Nakajima, K., 2012 Oct 18, In : Neuron. 76, 2, p. 353-369 17 p.

Research output: Contribution to journalArticle

Cell-Matrix Junctions
Integrins
Fibronectins
Neocortex
Extracellular Matrix
2011

[Final report of the working group for the future planning of the Japanese Association of Anatomists].

Yaginuma, H., Matsumura, G., Mori, C., Maeda, T., Araki, N., Noda, Y., Nakajima, K., Kawata, M., Okabe, S. & Working group for the future planning of the Japanese Association of Anatomists, G. F. T. F. P. O. T. J. A. O. A., 2011 Jun, In : Kaibogaku zasshi. Journal of anatomy. 86, 2, p. 39-44 6 p.

Research output: Contribution to journalArticle

Anatomists
Anatomy
Research Personnel
Education
Foster Home Care