• 2335 Citations
  • 28 h-Index
1992 …2020

Research output per year

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Research Output

  • 2335 Citations
  • 28 h-Index
  • 99 Article
  • 3 Chapter
  • 3 Review article
2020

Identification of vibsanin A analog as a novel HSP90 inhibitor

Miura, K., Matsuki, W., Ogura, A., Takao, K. I. & Simizu, S., 2020 Jan 15, In : Bioorganic and Medicinal Chemistry. 28, 2, 115253.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Stereoselective Synthesis of the Tricyclic Core of (-)-Callophycoic Acid A

Sakama, A., Kameshima, R., Motohashi, Y., Sumida, W., Unno, Y., Yoshida, K., Ogura, A. & Takao, K. I., 2020 Mar 6, In : Journal of Organic Chemistry. 85, 5, p. 3245-3264 20 p.

Research output: Contribution to journalArticle

Total Synthesis of Natural Products Using Intramolecular Nozaki-Hiyama-Takai-Kishi Reactions

Takao, K. I., Ogura, A., Yoshida, K. & Simizu, S., 2020 Mar 17, In : Synlett. 31, 5, p. 421-433 13 p.

Research output: Contribution to journalArticle

2019

Identification of topoisomerases as molecular targets of cytosporolide C and its analog

Otake, K., Yamada, K., Miura, K., Sasazawa, Y., Miyazaki, S., Niwa, Y., Ogura, A., Takao, K. I. & Simizu, S., 2019 Jan 1, In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Studies toward the synthesis of perforatumone: Synthesis of the 7-OXABICYCLO[4.2.1]NONANE-8,9-DIONE CORE

Nakajima, T., Takiguchi, K., Yoshida, K., Ogura, A. & Takao, K. I., 2019 Jan 1, In : Heterocycles. p. 661-668 8 p.

Research output: Contribution to journalArticle

Total Syntheses of (+)-Aquatolide and Related Humulanolides

Takao, K. I., Kai, H., Yamada, A., Fukushima, Y., Komatsu, D., Ogura, A. & Yoshida, K., 2019 Jul 15, In : Angewandte Chemie - International Edition. 58, 29, p. 9851-9855 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2018

Enantioselective Total Synthesis of (-)-Misramine

Yoshida, K., Fujino, Y., Takamatsu, Y., Matsui, K., Ogura, A., Fukami, Y., Kitagaki, S. & Takao, K-I., 2018 Aug 17, In : Organic Letters. 20, 16, p. 5044-5047 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Total Synthesis of Clavilactones

Takao, K. I., Mori, K., Kasuga, K., Nanamiya, R., Namba, A., Fukushima, Y., Nemoto, R., Mogi, T., Yasui, H., Ogura, A., Yoshida, K. & Tadano, K. I., 2018 Jul 6, In : Journal of Organic Chemistry. 83, 13, p. 7060-7075 16 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2017

Synthesis and evaluation of biological activities of vibsanin A analogs

Matsuki, W., Miyazaki, S., Yoshida, K., Ogura, A., Sasazawa, Y., Takao, K. I. & Simizu, S., 2017 Oct 1, In : Bioorganic and Medicinal Chemistry Letters. 27, 19, p. 4536-4539 4 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Total Synthesis and Structural Revision of Clavilactone D

Takao, K., Nemoto, R., Mori, K., Namba, A., Yoshida, K. & Ogura, A., 2017, In : Chemistry - A European Journal. 23, 16, p. 3828-3831 4 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2016

Amine-free silylation of alcohols under 4-methylpyridine N-oxide-catalyzed conditions

Yoshida, K., Fujino, Y., Itatsu, Y., Inoue, H., Kanoko, Y. & Takao, K., 2016 Feb 3, In : Tetrahedron Letters. 57, 5, p. 627-631 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Enantioselective Organocatalytic Construction of Spiroindane Derivatives by Intramolecular Friedel-Crafts-Type 1,4-Addition

Yoshida, K., Itatsu, Y., Fujino, Y., Inoue, H. & Takao, K. I., 2016, (Accepted/In press) In : Angewandte Chemie - International Edition.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Identification of seco-clavilactone B as a small-molecule actin polymerization inhibitor

Miyazaki, S., Sasazawa, Y., Mogi, T., Suzuki, T., Yoshida, K., Dohmae, N., Takao, K. I. & Simizu, S., 2016 Apr 1, In : FEBS Letters. 590, 8, p. 1163-1173 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Kinetically Controlled α-Selective O-Glycosylation of Phenol Derivatives Using 2-Nitroglycals by a Bifunctional Chiral Thiourea Catalyst

Yoshida, K., Kanoko, Y. & Takao, K., 2016 Oct 1, In : Asian Journal of Organic Chemistry. 5, 10, p. 1230-1236 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Organocatalytic Regioselective Chlorosilylation of Oxirane Derivatives: Mild and Effective Insertion of Bulky Silyl Chloride by Using 4-Methoxypyridine N-Oxide

Yoshida, K., Suzuki, H., Inoue, H., Matsui, K., Fujino, Y., Kanoko, Y., Itatsu, Y. & Takao, K., 2016, In : Advanced Synthesis and Catalysis. 358, 12, p. 1886-1891 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Stereoselective construction of all-carbon quaternary stereocenters by allylboration of chiral aldehydes: synthesis of a fragment of (+)-vibsanin A

Sakama, A., Nishimura, Y., Motohashi, Y., Yoshida, K. & Takao, K., 2016 Sep 1, In : Tetrahedron. 72, 35, p. 5465-5471 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2015

An access to the 13-membered cyclophane substructure in GKK1032AS: An intramolecular 1,4-addition approach

Nagai, S., Yamagishi, Y., Shimizu, Y., Takao, K. I. & Tadano, K. I., 2015, In : Heterocycles. 90, 2, p. 819-826 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Total Synthesis of (+)-Cytosporolide A via a Biomimetic Hetero-Diels-Alder Reaction

Takao, K., Noguchi, S., Sakamoto, S., Kimura, M., Yoshida, K. & Tadano, K. I., 2015 Dec 23, In : Journal of the American Chemical Society. 137, 50, p. 15971-15977 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Total synthesis of (+)-vibsanin A

Takao, K. I., Tsunoda, K., Kurisu, T., Sakama, A., Nishimura, Y., Yoshida, K. & Tadano, K. I., 2015 Feb 6, In : Organic Letters. 17, 3, p. 756-759 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Total synthesis of natural products using sequential olefin metathesis reactions

Takao, K. I., Yoshida, K. & Tadano, K. I., 2015, In : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 73, 12, p. 1192-1199 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2014

Catalytic silylation of secondary alcohols by pyridine N-oxide derivative

Yoshida, K. & Takao, K. I., 2014 Dec 10, In : Tetrahedron Letters. 55, 50, p. 6861-6863 3 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2013

Recent advances in the synthetic studies of pestalotiopsin A and related caryophyllene-type sesquiterpenoids

Takao, K. I. & Tadano, K. I., 2013, Studies in Natural Products Chemistry. Elsevier B.V., p. 161-187 27 p. (Studies in Natural Products Chemistry; vol. 39).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Synthetic studies of the spirocyclic cyclohexene part of versipelostatin, a novel GRP78/Bip molecular chaperone downregulator

Sasaki, S., Samejima, S., Uruga, T., Anzai, K., Nishi, N., Kawakita, E., Takao, K. I. & Tadano, K. I., 2013 Mar 1, In : Journal of Antibiotics. 66, 3, p. 147-154 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Total synthesis of (+)-clavilactone A and (-)-clavilactone B by ring-opening/ring-closing metathesis

Takao, K. I., Nanamiya, R., Fukushima, Y., Namba, A., Yoshida, K. & Tadano, K. I., 2013 Nov 1, In : Organic Letters. 15, 21, p. 5582-5585 4 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
2012

Asymmetric construction of all-carbon quaternary stereocenters by chiral-auxiliary-mediated claisen rearrangement and total synthesis of (+)-Bakuchiol

Takao, K. I., Shu, S., Touati, M. A., Kusakawa, Y. & Tadano, K. I., 2012 Nov 1, In : Molecules. 17, 11, p. 13330-13344 15 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Construction of all-carbon quaternary stereocenters by zinc-mediated barbier-type allylation in aqueous media

Takao, K. I., Miyashita, T., Akiyama, N., Kurisu, T., Tsunoda, K. & Tadano, K. I., 2012 Dec 1, In : Heterocycles. 86, 1, p. 147-153 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Determination of the absolute structure of (+)-akaterpin

Hosoi, H., Kawai, N., Hagiwara, H., Suzuki, T., Nakazaki, A., Takao, K. I., Umezaw, K. & Kobayashi, S., 2012 Jan 1, In : Chemical and Pharmaceutical Bulletin. 60, 1, p. 137-143 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2011

Some stereoselective carbon-carbon bond-forming reactions realized by using sugar-derived chiral templates

Totani, K., Takao, K. I. & Tadano, K. I., 2011 Dec 1, In : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 69, 12, p. 1363-1374 12 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Synthesis and determination of the relative structure of akaterpin, a potent inhibitor of PI-PLC

Hosoi, H., Kawai, N., Hagiwara, H., Suzuki, T., Nakazaki, A., Takao, K. I., Umezawa, K. & Kobayashi, S., 2011 Sep 21, In : Tetrahedron Letters. 52, 38, p. 4961-4964 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Total syntheses of (+)-spiculoic acid A and (+)-zyggomphic acid, new marine natural products of polyketide origin

Matsumura, D., Takarabe, T., Toda, T., Hayamizu, T., Sawamura, K., Takao, K. I. & Tadano, K. I., 2011 Sep 2, In : Tetrahedron. 67, 35, p. 6730-6745 16 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2010

Synthesis of nitrogen-and oxygen-bridged seven-to ten-membered carbocycles using metathesis reactions

Takao, K. I. & Tadano, K. I., 2010 Dec 1, In : Heterocycles. 81, 7, p. 1603-1629 27 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2009

Enantioselective synthesis of A 3,5,5-trialkylated tetronic acid derivative

Takao, K. I., Kojima, Y., Miyashita, T., Yashiro, K., Yamada, T. & Tadano, K. I., 2009 Jan 1, In : Heterocycles. 77, 1, p. 167-172 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Stereoselective α-alkylation of methyl 6-deoxy-3,4-di-O-(tert-butyldimethylsilyl)-2-O-(2-methyl-3-oxobutanoyl)-α-d-glucopyranoside

Akashi, Y., Takao, K. I. & Tadano, K. I., 2009 Mar 11, In : Tetrahedron Letters. 50, 10, p. 1139-1142 4 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Total syntheses of (+)- and (-)-pestalotiopsin A

Takao, K. I., Hayakawa, N., Yamada, R., Yamaguchi, T., Saegusa, H., Uchida, M., Samejima, S. & Tadano, K. I., 2009 Sep 4, In : Journal of Organic Chemistry. 74, 17, p. 6452-6461 10 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Total synthesis of (-)-norzoanthamine

Yamashita, D., Murata, Y., Hikage, N., Takao, K. I., Nakazaki, A. & Kobayashi, S., 2009 Feb 9, In : Angewandte Chemie - International Edition. 48, 8, p. 1404-1406 3 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Total synthesis of (+)-spiculoic acid A

Matsumura, D., Toda, T., Hayamizu, T., Sawamura, K., Takao, K. I. & Tadano, K. I., 2009 Jul 1, In : Tetrahedron Letters. 50, 26, p. 3356-3358 3 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2008

Stereoselective synthesis of highly enantioenriched 3-methyl-2-cyclohexen-1-ones possessing an asymmetric quaternary carbon as C-4 or C-6: a sugar template approach

Kubo, H., Kozawa, I., Takao, K. I. & Tadano, K. I., 2008 Feb 11, In : Tetrahedron Letters. 49, 7, p. 1203-1207 5 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Total synthesis of (-)-pestalotiopsin A

Takao, K. I., Hayakawa, N., Yamada, R., Yamaguchi, T., Morita, U., Kawasaki, S. & Tadano, K. I., 2008 Apr 21, In : Angewandte Chemie - International Edition. 47, 18, p. 3426-3429 4 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2007

Formal synthesis of tubelactomicins via a transannular Diels-Alder approach

Anzo, T., Suzuki, A., Sawamura, K., Motozaki, T., Hatta, M., Takao, K. I. & Tadano, K. I., 2007 Nov 26, In : Tetrahedron Letters. 48, 48, p. 8442-8448 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Stereoselective double alkylation of the acetoacetate ester α-carbon on a D-glucose-derived template: Application to the synthesis of enantiopure cycloalkenones bearing an asymmetric quaternary carbon

Kozawa, I., Akashi, Y., Takiguchi, K., Sasaki, D., Sawamoto, D., Takao, K. I. & Tadano, K. I., 2007 Feb 15, In : Synlett. 3, p. 399-402 4 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Stereoselective mannich-like reactions of ester enolates generated on sugar templates: A novel access to a key intermediate for 1β-methylcarbapenem synthesis

Sasaki, D., Sawamoto, D., Takao, K. I., Tadano, K. I., Okue, M. & Ajito, K., 2007 Apr 13, In : Heterocycles. 72, p. 103-110 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Total syntheses of natural tubelactomicins B, D, and E: Establishment of their stereochemistries

Sawamura, K., Yoshida, K., Suzuki, A., Motozaki, T., Kozawa, I., Hayamizu, T., Munakata, R., Takao, K. I. & Tadano, K. I., 2007 Aug 1, In : Journal of Organic Chemistry. 72, 16, p. 6143-6148 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Total synthesis of structurally unique γ-Lactam natural products

Takao, K. I., Aoki, S. Y. & Tadano, K. I., 2007 May, In : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 65, 5, p. 460-469 10 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)
2006

Synthetic studies toward clavilactone A: A concise access to,-substituted -butenolides by metathesis

Yasui, H., Yamamoto, S., Takao, K. I. & Tadano, K. I., 2006 Dec 31, In : Heterocycles. 70, p. 135-141 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Total syntheses of (+)-1893B and its three diastereomers and evaluation of their biological activities

Yasui, H., Hirai, K., Yamamoto, S., Takao, K. I. & Tadano, K. I., 2006 Aug, In : Journal of Antibiotics. 59, 8, p. 456-463 8 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Total synthesis of (-)-Pramanicin

Aoki, S. Y., Tsukude, T., Miyazaki, Y., Takao, K. I. & Tadano, K. I., 2006 Dec 1, In : Heterocycles. 69, 1, p. 49-54 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Total synthesis of (+)-1893B aimed at establishing its stereochemistry

Yasui, H., Hirai, K., Yamamoto, S., Takao, K. I. & Tadano, K. I., 2006 Jan 1, In : Heterocycles. 67, 1, p. 123-128 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2005

Recent advances in natural product synthesis by using intramolecular Diels-Alder reactions

Takao, K. I., Munakata, R. & Tadano, K. I., 2005 Dec 1, In : Chemical Reviews. 105, 12, p. 4779-4807 29 p.

Research output: Contribution to journalReview article

502 Citations (Scopus)

Synthetic studies of pestalotiopsin A: Asymmetric synthesis of the 2-oxabicyclo[3.2.0]heptane substructure

Takao, K. I., Saegusa, H., Tsujita, T., Washizawa, T. & Tadano, K. I., 2005 Aug 29, In : Tetrahedron Letters. 46, 35, p. 5815-5818 4 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Total synthesis of (+)-tubelactomicin A. 1. Stereoselective synthesis of the lower-half segment by an intramolecular Diels-Alder approach

Motozaki, T., Sawamura, K., Suzuki, A., Yoshida, K., Ueki, T., Ohara, A., Munakata, R., Takao, K. I. & Tadano, K. I., 2005 May 26, In : Organic Letters. 7, 11, p. 2261-2264 4 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)