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Research Output 1992 2019

  • 2224 Citations
  • 27 h-Index
  • 101 Article
  • 1 Chapter
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2019

Identification of topoisomerases as molecular targets of cytosporolide C and its analog

Otake, K., Yamada, K., Miura, K., Sasazawa, Y., Miyazaki, S., Niwa, Y., Ogura, A., Takao, K. & Simizu, S., 2019 Jan 1, In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

Type I DNA Topoisomerase
Type II DNA Topoisomerase
Cells
Neoplasms
Biomimetics

Studies toward the synthesis of perforatumone: Synthesis of the 7-OXABICYCLO[4.2.1]NONANE-8,9-DIONE CORE

Nakajima, T., Takiguchi, K., Yoshida, K., Ogura, A. & Takao, K., 2019 Jan 1, In : Heterocycles. p. 661-668 8 p.

Research output: Contribution to journalArticle

Skeleton
Condensation
perforatumone
nonane

Total Syntheses of (+)-Aquatolide and Related Humulanolides

Takao, K., Kai, H., Yamada, A., Fukushima, Y., Komatsu, D., Ogura, A. & Yoshida, K., 2019 Jan 1, In : Angewandte Chemie - International Edition.

Research output: Contribution to journalArticle

Biomimetics
aquatolide
2018
1 Citation (Scopus)

Enantioselective Total Synthesis of (-)-Misramine

Yoshida, K., Fujino, Y., Takamatsu, Y., Matsui, K., Ogura, A., Fukami, Y., Kitagaki, S. & Takao, K-I., 2018 Aug 17, In : Organic Letters. 20, 16, p. 5044-5047 4 p.

Research output: Contribution to journalArticle

Alkaloids
alkaloids
Amination
synthesis
Skeleton
4 Citations (Scopus)

Total Synthesis of Clavilactones

Takao, K., Mori, K., Kasuga, K., Nanamiya, R., Namba, A., Fukushima, Y., Nemoto, R., Mogi, T., Yasui, H., Ogura, A., Yoshida, K. & Tadano, K. I., 2018 Jul 6, In : Journal of Organic Chemistry. 83, 13, p. 7060-7075 16 p.

Research output: Contribution to journalArticle

Bearings (structural)
Acetals
Enantiomers
Fungi
Epidermal Growth Factor Receptor
2017
3 Citations (Scopus)

Synthesis and evaluation of biological activities of vibsanin A analogs

Matsuki, W., Miyazaki, S., Yoshida, K., Ogura, A., Sasazawa, Y., Takao, K. & Simizu, S., 2017 Oct 1, In : Bioorganic and Medicinal Chemistry Letters. 27, 19, p. 4536-4539 4 p.

Research output: Contribution to journalArticle

Bioactivity
Myeloid Cells
Acute Myeloid Leukemia
Protein Kinase C
Cell Differentiation
6 Citations (Scopus)

Total Synthesis and Structural Revision of Clavilactone D

Takao, K., Nemoto, R., Mori, K., Namba, A., Yoshida, K. & Ogura, A., 2017, In : Chemistry - A European Journal. 23, 16, p. 3828-3831 4 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Proteins
clavilactone D
butenolide
2016
4 Citations (Scopus)

Amine-free silylation of alcohols under 4-methylpyridine N-oxide-catalyzed conditions

Yoshida, K., Fujino, Y., Itatsu, Y., Inoue, H., Kanoko, Y. & Takao, K., 2016 Feb 3, In : Tetrahedron Letters. 57, 5, p. 627-631 5 p.

Research output: Contribution to journalArticle

Ethers
Oxides
Amines
Alcohols
Temperature
17 Citations (Scopus)

Enantioselective Organocatalytic Construction of Spiroindane Derivatives by Intramolecular Friedel-Crafts-Type 1,4-Addition

Yoshida, K., Itatsu, Y., Fujino, Y., Inoue, H. & Takao, K., 2016, (Accepted/In press) In : Angewandte Chemie - International Edition.

Research output: Contribution to journalArticle

Spiro Compounds
Enantioselectivity
Biological Products
Amines
Carbon
5 Citations (Scopus)

Identification of seco-clavilactone B as a small-molecule actin polymerization inhibitor

Miyazaki, S., Sasazawa, Y., Mogi, T., Suzuki, T., Yoshida, K., Dohmae, N., Takao, K. & Simizu, S., 2016 Apr 1, In : FEBS Letters. 590, 8, p. 1163-1173 11 p.

Research output: Contribution to journalArticle

Polymerization
Actins
Molecules
Actin Cytoskeleton
clavilactone B
8 Citations (Scopus)

Kinetically Controlled α-Selective O-Glycosylation of Phenol Derivatives Using 2-Nitroglycals by a Bifunctional Chiral Thiourea Catalyst

Yoshida, K., Kanoko, Y. & Takao, K., 2016 Oct 1, In : Asian Journal of Organic Chemistry. 5, 10, p. 1230-1236 7 p.

Research output: Contribution to journalArticle

Glycosylation
Stereoselectivity
Thiourea
Phenol
Derivatives
3 Citations (Scopus)

Organocatalytic Regioselective Chlorosilylation of Oxirane Derivatives: Mild and Effective Insertion of Bulky Silyl Chloride by Using 4-Methoxypyridine N-Oxide

Yoshida, K., Suzuki, H., Inoue, H., Matsui, K., Fujino, Y., Kanoko, Y., Itatsu, Y. & Takao, K., 2016, In : Advanced Synthesis and Catalysis. 358, 12, p. 1886-1891 6 p.

Research output: Contribution to journalArticle

Ethylene Oxide
Regioselectivity
Sodium sulfate
Oxides
Chlorides

Stereoselective construction of all-carbon quaternary stereocenters by allylboration of chiral aldehydes: synthesis of a fragment of (+)-vibsanin A

Sakama, A., Nishimura, Y., Motohashi, Y., Yoshida, K. & Takao, K., 2016 Sep 1, In : Tetrahedron. 72, 35, p. 5465-5471 7 p.

Research output: Contribution to journalArticle

Aldehydes
Carbon
Sugars
vibsanin A
2015
4 Citations (Scopus)

An access to the 13-membered cyclophane substructure in GKK1032AS: An intramolecular 1,4-addition approach

Nagai, S., Yamagishi, Y., Shimizu, Y., Takao, K. & Tadano, K. I., 2015, In : Heterocycles. 90, 2, p. 819-826 8 p.

Research output: Contribution to journalArticle

Pyrrolidinones
Biological Products
Ketones
21 Citations (Scopus)

Total Synthesis of (+)-Cytosporolide A via a Biomimetic Hetero-Diels-Alder Reaction

Takao, K., Noguchi, S., Sakamoto, S., Kimura, M., Yoshida, K. & Tadano, K. I., 2015 Dec 23, In : Journal of the American Chemical Society. 137, 50, p. 15971-15977 7 p.

Research output: Contribution to journalArticle

Biomimetics
Cycloaddition Reaction
Carboxylic Acids
Skeleton
Stereoselectivity
9 Citations (Scopus)

Total synthesis of (+)-vibsanin A

Takao, K., Tsunoda, K., Kurisu, T., Sakama, A., Nishimura, Y., Yoshida, K. & Tadano, K. I., 2015 Feb 6, In : Organic Letters. 17, 3, p. 756-759 4 p.

Research output: Contribution to journalArticle

Diterpenes
Skeleton
Zinc
Carbon
Allylation
2 Citations (Scopus)

Total synthesis of natural products using sequential olefin metathesis reactions

Takao, K., Yoshida, K. & Tadano, K. I., 2015, In : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 73, 12, p. 1192-1199 8 p.

Research output: Contribution to journalArticle

ROM
Alkenes
Biological Products
Derivatives
Oxygen
2014
8 Citations (Scopus)

Catalytic silylation of secondary alcohols by pyridine N-oxide derivative

Yoshida, K. & Takao, K., 2014 Dec 10, In : Tetrahedron Letters. 55, 50, p. 6861-6863 3 p.

Research output: Contribution to journalArticle

Ethers
Oxides
Chlorides
Alcohols
Derivatives
2013
3 Citations (Scopus)

Synthetic studies of the spirocyclic cyclohexene part of versipelostatin, a novel GRP78/Bip molecular chaperone downregulator

Sasaki, S., Samejima, S., Uruga, T., Anzai, K., Nishi, N., Kawakita, E., Takao, K. & Tadano, K. I., 2013 Mar, In : Journal of Antibiotics. 66, 3, p. 147-154 8 p.

Research output: Contribution to journalArticle

Carboxylic Acids
Carbon
Glucose
versipelostatin
tetronic acid
33 Citations (Scopus)

Total synthesis of (+)-clavilactone A and (-)-clavilactone B by ring-opening/ring-closing metathesis

Takao, K., Nanamiya, R., Fukushima, Y., Namba, A., Yoshida, K. & Tadano, K. I., 2013 Nov 1, In : Organic Letters. 15, 21, p. 5582-5585 4 p.

Research output: Contribution to journalArticle

metathesis
closing
Enantiomers
rings
enantiomers
2012
10 Citations (Scopus)

Asymmetric construction of all-carbon quaternary stereocenters by chiral-auxiliary-mediated claisen rearrangement and total synthesis of (+)-Bakuchiol

Takao, K., Shu, S., Touati, M. A., Kusakawa, Y. & Tadano, K. I., 2012 Nov, In : Molecules. 17, 11, p. 13330-13344 15 p.

Research output: Contribution to journalArticle

Stereoselectivity
Carbon
Hot Temperature
carbon
Substrates
6 Citations (Scopus)

Construction of all-carbon quaternary stereocenters by zinc-mediated barbier-type allylation in aqueous media

Takao, K., Miyashita, T., Akiyama, N., Kurisu, T., Tsunoda, K. & Tadano, K. I., 2012, In : Heterocycles. 86, 1, p. 147-153 7 p.

Research output: Contribution to journalArticle

Bearings (structural)
Allylation
Glyceraldehyde
Stereoselectivity
2,4-Dichlorophenoxyacetic Acid
2 Citations (Scopus)

Determination of the absolute structure of (+)-akaterpin

Hosoi, H., Kawai, N., Hagiwara, H., Suzuki, T., Nakazaki, A., Takao, K., Umezaw, K. & Kobayashi, S., 2012 Jan, In : Chemical and Pharmaceutical Bulletin. 60, 1, p. 137-143 7 p.

Research output: Contribution to journalArticle

Optical rotation
Phosphoinositide Phospholipase C
Optical Rotation
Stereochemistry
Ketones
2011
1 Citation (Scopus)
Sugars
Carbon
Cycloaddition
Glucose
Ethers
4 Citations (Scopus)

Synthesis and determination of the relative structure of akaterpin, a potent inhibitor of PI-PLC

Hosoi, H., Kawai, N., Hagiwara, H., Suzuki, T., Nakazaki, A., Takao, K., Umezawa, K. & Kobayashi, S., 2011 Sep 21, In : Tetrahedron Letters. 52, 38, p. 4961-4964 4 p.

Research output: Contribution to journalArticle

Phosphoinositide Phospholipase C
Stereochemistry
Alkylation
Cycloaddition Reaction
Nuclear magnetic resonance
5 Citations (Scopus)

Total syntheses of (+)-spiculoic acid A and (+)-zyggomphic acid, new marine natural products of polyketide origin

Matsumura, D., Takarabe, T., Toda, T., Hayamizu, T., Sawamura, K., Takao, K. & Tadano, K. I., 2011 Sep 2, In : Tetrahedron. 67, 35, p. 6730-6745 16 p.

Research output: Contribution to journalArticle

Polyketides
Biological Products
Acids
Cycloaddition Reaction
Skeleton
2010
25 Citations (Scopus)

Synthesis of nitrogen-and oxygen-bridged seven-to ten-membered carbocycles using metathesis reactions

Takao, K. & Tadano, K. I., 2010, In : Heterocycles. 81, 7, p. 1603-1629 27 p.

Research output: Contribution to journalArticle

Biological Products
Nitrogen
Oxygen
2009
7 Citations (Scopus)

Enantioselective synthesis of A 3,5,5-trialkylated tetronic acid derivative

Takao, K., Kojima, Y., Miyashita, T., Yashiro, K., Yamada, T. & Tadano, K. I., 2009 Jan 1, In : Heterocycles. 77, 1, p. 167-172 6 p.

Research output: Contribution to journalArticle

Derivatives
Biological Products
Chlorides
Condensation
Quenching
10 Citations (Scopus)

Stereoselective α-alkylation of methyl 6-deoxy-3,4-di-O-(tert-butyldimethylsilyl)-2-O-(2-methyl-3-oxobutanoyl)-α-d-glucopyranoside

Akashi, Y., Takao, K. & Tadano, K. I., 2009 Mar 11, In : Tetrahedron Letters. 50, 10, p. 1139-1142 4 p.

Research output: Contribution to journalArticle

Alkylation
Carbon
Allylation
Stereochemistry
Derivatives
27 Citations (Scopus)

Total syntheses of (+)- and (-)-pestalotiopsin A

Takao, K., Hayakawa, N., Yamada, R., Yamaguchi, T., Saegusa, H., Uchida, M., Samejima, S. & Tadano, K. I., 2009 Sep 4, In : Journal of Organic Chemistry. 74, 17, p. 6452-6461 10 p.

Research output: Contribution to journalArticle

Acetals
Mesylates
Stereochemistry
Cycloaddition
Enantiomers
27 Citations (Scopus)

Total synthesis of (-)-norzoanthamine

Yamashita, D., Murata, Y., Hikage, N., Takao, K., Nakazaki, A. & Kobayashi, S., 2009 Feb 9, In : Angewandte Chemie - International Edition. 48, 8, p. 1404-1406 3 p.

Research output: Contribution to journalArticle

Cyclization
Bone
Pharmaceutical Preparations
cyclopentanol
norzoanthamine
14 Citations (Scopus)

Total synthesis of (+)-spiculoic acid A

Matsumura, D., Toda, T., Hayamizu, T., Sawamura, K., Takao, K. & Tadano, K. I., 2009 Jul 1, In : Tetrahedron Letters. 50, 26, p. 3356-3358 3 p.

Research output: Contribution to journalArticle

Polyketides
Cycloaddition Reaction
Biological Products
Skeleton
Derivatives
2008
8 Citations (Scopus)

Stereoselective synthesis of highly enantioenriched 3-methyl-2-cyclohexen-1-ones possessing an asymmetric quaternary carbon as C-4 or C-6: a sugar template approach

Kubo, H., Kozawa, I., Takao, K. & Tadano, K. I., 2008 Feb 11, In : Tetrahedron Letters. 49, 7, p. 1203-1207 5 p.

Research output: Contribution to journalArticle

Carboxylic Acids
Sugars
Carbon
Condensation
Derivatives
29 Citations (Scopus)

Total synthesis of (-)-pestalotiopsin A

Takao, K., Hayakawa, N., Yamada, R., Yamaguchi, T., Morita, U., Kawasaki, S. & Tadano, K. I., 2008 Apr 21, In : Angewandte Chemie - International Edition. 47, 18, p. 3426-3429 4 p.

Research output: Contribution to journalArticle

Stereochemistry
Cycloaddition
Cycloaddition Reaction
pestalotiopsin A
3-hydroxybutanal
2007
13 Citations (Scopus)

Formal synthesis of tubelactomicins via a transannular Diels-Alder approach

Anzo, T., Suzuki, A., Sawamura, K., Motozaki, T., Hatta, M., Takao, K. & Tadano, K. I., 2007 Nov 26, In : Tetrahedron Letters. 48, 48, p. 8442-8448 7 p.

Research output: Contribution to journalArticle

Macrolides
Cycloaddition Reaction
Cyclization
tubelactomicin A
tubelactomicin E
11 Citations (Scopus)

Stereoselective double alkylation of the acetoacetate ester α-carbon on a D-glucose-derived template: Application to the synthesis of enantiopure cycloalkenones bearing an asymmetric quaternary carbon

Kozawa, I., Akashi, Y., Takiguchi, K., Sasaki, D., Sawamoto, D., Takao, K. & Tadano, K. I., 2007 Feb 15, In : Synlett. 3, p. 399-402 4 p.

Research output: Contribution to journalArticle

Bearings (structural)
Alkylation
Esters
Carbon
Derivatives
4 Citations (Scopus)

Stereoselective mannich-like reactions of ester enolates generated on sugar templates: A novel access to a key intermediate for 1β-methylcarbapenem synthesis

Sasaki, D., Sawamoto, D., Takao, K., Tadano, K. I., Okue, M. & Ajito, K., 2007 Apr 13, In : Heterocycles. 72, p. 103-110 8 p.

Research output: Contribution to journalArticle

Stereoselectivity
Sugars
Acetic Acid
Hydrolysis
Esters
16 Citations (Scopus)

Total syntheses of natural tubelactomicins B, D, and E: Establishment of their stereochemistries

Sawamura, K., Yoshida, K., Suzuki, A., Motozaki, T., Kozawa, I., Hayamizu, T., Munakata, R., Takao, K. & Tadano, K. I., 2007 Aug, In : Journal of Organic Chemistry. 72, 16, p. 6143-6148 6 p.

Research output: Contribution to journalArticle

Stereochemistry
Macrolides
tubelactomicin B
tubelactomicin D
11 Citations (Scopus)

Total synthesis of structurally unique γ-Lactam natural products

Takao, K., Aoki, S. Y. & Tadano, K. I., 2007 May, In : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 65, 5, p. 460-469 10 p.

Research output: Contribution to journalArticle

Lactams
Biological Products
Bioactivity
pseurotin
2006
13 Citations (Scopus)

Synthetic studies toward clavilactone A: A concise access to,-substituted -butenolides by metathesis

Yasui, H., Yamamoto, S., Takao, K. & Tadano, K. I., 2006 Dec 31, In : Heterocycles. 70, p. 135-141 7 p.

Research output: Contribution to journalArticle

Cyclization
Palladium
Alkenes
Lactones
Acetates
5 Citations (Scopus)

Total syntheses of (+)-1893B and its three diastereomers and evaluation of their biological activities

Yasui, H., Hirai, K., Yamamoto, S., Takao, K. & Tadano, K. I., 2006 Aug, In : Journal of Antibiotics. 59, 8, p. 456-463 8 p.

Research output: Contribution to journalArticle

Alkynes
Lactones
11 Citations (Scopus)

Total synthesis of (-)-Pramanicin

Aoki, S. Y., Tsukude, T., Miyazaki, Y., Takao, K. & Tadano, K. I., 2006 Dec 1, In : Heterocycles. 69, 1, p. 49-54 6 p.

Research output: Contribution to journalArticle

Lactams
Antifungal Agents
Biological Products
propylene
pramanicin
12 Citations (Scopus)

Total synthesis of (+)-1893B aimed at establishing its stereochemistry

Yasui, H., Hirai, K., Yamamoto, S., Takao, K. & Tadano, K. I., 2006 Jan 1, In : Heterocycles. 67, 1, p. 123-128 6 p.

Research output: Contribution to journalArticle

Stereochemistry
Palladium
Lactones
Oxidation
2005
479 Citations (Scopus)

Recent advances in natural product synthesis by using intramolecular Diels-Alder reactions

Takao, K., Munakata, R. & Tadano, K. I., 2005 Dec, In : Chemical Reviews. 105, 12, p. 4779-4807 29 p.

Research output: Contribution to journalArticle

Biological Products
17 Citations (Scopus)

Synthetic studies of pestalotiopsin A: Asymmetric synthesis of the 2-oxabicyclo[3.2.0]heptane substructure

Takao, K., Saegusa, H., Tsujita, T., Washizawa, T. & Tadano, K. I., 2005 Aug 29, In : Tetrahedron Letters. 46, 35, p. 5815-5818 4 p.

Research output: Contribution to journalArticle

Cyclobutanes
Heptanes
Lewis Acids
Acetals
Cycloaddition Reaction
26 Citations (Scopus)

Total synthesis of (+)-tubelactomicin A. 1. Stereoselective synthesis of the lower-half segment by an intramolecular Diels-Alder approach

Motozaki, T., Sawamura, K., Suzuki, A., Yoshida, K., Ueki, T., Ohara, A., Munakata, R., Takao, K. & Tadano, K. I., 2005 May 26, In : Organic Letters. 7, 11, p. 2261-2264 4 p.

Research output: Contribution to journalArticle

Carbon
tethering
Derivatives
Diels-Alder reactions
antibiotics
39 Citations (Scopus)

Total synthesis of (+)-tubelactomicin A. 2. Synthesis of the upper-half segment and completion of the total synthesis

Motozaki, T., Sawamura, K., Suzuki, A., Yoshida, K., Ueki, T., Ohara, A., Munakata, R., Takao, K. & Tadano, K. I., 2005 May 26, In : Organic Letters. 7, 11, p. 2265-2267 3 p.

Research output: Contribution to journalArticle

Macrolides
Anti-Bacterial Agents
synthesis
antibiotics
tubelactomicin A
2004
62 Citations (Scopus)

Asymmetric total syntheses of (+)-mycoepoxydiene and related natural product (-)-1893A: Application of one-pot ring-opening/cross/ring-closing metathesis to construct their 9-oxabicyclo[4.2.1]nona-2,4-diene skeleton

Takao, K., Yasui, H., Yamamoto, S., Sasaki, D., Kawasaki, S., Watanabe, G. & Tadano, K. I., 2004 Dec 10, In : Journal of Organic Chemistry. 69, 25, p. 8789-8795 7 p.

Research output: Contribution to journalArticle

Biological Products
Stereochemistry
ROM
Derivatives
mycoepoxydiene
31 Citations (Scopus)

Sugar as a tool for asymmetric synthesis: Some effective approaches

Totani, K., Takao, K. & Tadano, K. I., 2004 Oct 1, In : Synlett. 12, p. 2066-2080 15 p.

Research output: Contribution to journalArticle

Sugars
Esters
Addition reactions
Carbon
Alkylation
35 Citations (Scopus)

Total syntheses of natural pseurotins A, F2, and azaspirene

Aoki, S. Y., Oi, T., Shimizu, K., Shiraki, R., Takao, K. & Tadano, K. I., 2004, In : Bulletin of the Chemical Society of Japan. 77, 9, p. 1703-1716 14 p.

Research output: Contribution to journalArticle

Lactones
Lactams
Carbon
Chitin Synthase
Derivatives