Research Output 1999 2017

  • 1710 Citations
  • 19 h-Index
  • 33 Article
  • 2 Comment/debate
  • 1 Letter
  • 1 Review article
2017
1 Citations

Excessive activation of AhR signaling disrupts neuronal migration in the hippocampal CA1 region in the developing mouse

Kimura, E., Kubo, K. I., Endo, T., Nakajima, K., Kakeyama, M. & Tohyama, C. 2017 In : Journal of Toxicological Sciences. 42, 1, p. 25-30 6 p.

Research output: Contribution to journalLetter

Hippocampal CA1 Region
Aryl Hydrocarbon Receptors
Chemical activation
Dioxins
Xenobiotics
1 Citations

Impaired dendritic growth and positioning of cortical pyramidal neurons by activation of aryl hydrocarbon receptor signaling in the developing mouse

Kimura, E., Kubo, K. I., Endo, T., Ling, W., Nakajima, K., Kakeyama, M. & Tohyama, C. 2017 Aug 1 In : PLoS ONE. 12, 8, e0183497

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Pyramidal Cells
Neurons
hydrocarbons
neurons
3 Citations

Reelin transiently promotes N-cadherin-dependent neuronal adhesion during mouse cortical development

Matsunaga, Y., Noda, M., Murakawa, H., Hayashi, K., Nagasaka, A., Inoue, S., Miyata, T., Miura, T., Kubo, K. I. & Nakajima, K. 2017 Feb 21 In : Proceedings of the National Academy of Sciences of the United States of America. 114, 8, p. 2048-2053 6 p.

Research output: Contribution to journalArticle

Cadherins
Neurons
Ependymoglial Cells
Adhesiveness
Neocortex
2016
9 Citations

DISC1 a key molecular lead in psychiatry and neurodevelopment: No-More Disrupted-in-Schizophrenia 1

Niwa, M., Cash-Padgett, T., Kubo, K. I., Saito, A., Ishii, K., Sumitomo, A., Taniguchi, Y., Ishizuka, K., Jaaro-Peled, H., Tomoda, T., Nakajima, K., Sawa, A. & Kamiya, A. 2016 Nov 1 In : Molecular Psychiatry. 21, 11, p. 1488-1489 2 p.

Research output: Contribution to journalComment/debate

Islands
Schizophrenia
Japan
Emotions
corrigendum
2 Citations

In utero bisphenol A exposure induces abnormal neuronal migration in the cerebral cortex of mice

Ling, W., Endo, T., Kubo, K. I., Nakajima, K., Kakeyama, M. & Tohyama, C. 2016 In : Frontiers in Endocrinology. 7, FEB, 7

Research output: Contribution to journalArticle

Cerebral Cortex
Electroporation
bisphenol A
Brain
Laboratory Animals
8 Citations

Reelin and neuropsychiatric disorders

Ishii, K., Kubo, K. I. & Nakajima, K. 2016 Oct 18 In : Frontiers in Cellular Neuroscience. 10, OCT2016, 229

Research output: Contribution to journalReview article

Psychiatry
Haploinsufficiency
Medical Genetics
Brain
Interneurons
2 Citations

Resilience in schizophrenia: A comparative study between a remote island and an urban area in Japan

Yoshida, K., Suzuki, T., Imasaka, Y., Kubo, K. I., Mizuno, Y., Saruta, J., Tsukinoki, K., Mimura, M. & Uchida, H. 2016 Mar 1 In : Schizophrenia Research. 171, 1-3, p. 92-96 5 p.

Research output: Contribution to journalArticle

Tokyo
Islands
Schizophrenia
Japan
Biomarkers
2015
10 Citations

Cellular dynamics of neuronal migration in the hippocampus

Hayashi, K., Kubo, K. I., Kitazawa, A. & Nakajima, K. 2015 In : Frontiers in Neuroscience. 9, APR, 135

Research output: Contribution to journalArticle

Hippocampus
Neurons
Pyramidal Cells
Rodentia
Psychiatry
45 Citations

Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS

Yamakawa, M., Ito, D., Honda, T., Kubo, K. I., Noda, M., Nakajima, K. & Suzuki, N. 2015 In : Human Molecular Genetics. 24, 6, p. 1630-1645 16 p., ddu576

Research output: Contribution to journalArticle

Dipeptides
Amyotrophic Lateral Sclerosis
Glycine
Ubiquitin
Proline
9 Citations

Developmental origin of abnormal dendritic growth in the mouse brain induced by in utero disruption of aryl hydrocarbon receptor signaling

Kimura, E., Kubo, K. I., Matsuyoshi, C., Benner, S., Hosokawa, M., Endo, T., Ling, W., Kohda, M., Yokoyama, K., Nakajima, K., Kakeyama, M. & Tohyama, C. 2015 Nov 1 In : Neurotoxicology and Teratology. 52, p. 42-50 9 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Brain
Hippocampus
Dioxins
Growth
22 Citations

Importance of reelin C-terminal region in the development and maintenance of the postnatal cerebral cortex and its regulation by specific proteolysis

Kohno, T., Honda, T., Kubo, K. I., Nakano, Y., Tsuchiya, A., Murakami, T., Banno, H., Nakajima, K. & Hattori, M. 2015 In : Journal of Neuroscience. 35, 11, p. 4776-4787 12 p.

Research output: Contribution to journalArticle

Cerebral Cortex
Proteolysis
Maintenance
Dendrites
Phosphorylation
9 Citations

Neuronal heterotopias affect the activities of distant brain areas and lead to behavioral deficits

Ishii, K., Kubo, K. I., Endo, T., Yoshida, K., Benner, S., Ito, Y., Aizawa, H., Aramaki, M., Yamanaka, A., Tanaka, K., Takata, N., Tanaka, K. F., Mimura, M., Tohyama, C., Kakeyama, M. & Nakajima, K. 2015 Sep 9 In : Journal of Neuroscience. 35, 36, p. 12432-12445 14 p.

Research output: Contribution to journalArticle

Prefrontal Cortex
Memory Disorders
Short-Term Memory
Brain
Competitive Behavior
10 Citations

Reelin has a preventive effect on phencyclidine-induced cognitive and sensory-motor gating deficits

Ishii, K., Nagai, T., Hirota, Y., Noda, M., Nabeshima, T., Yamada, K., Kubo, K. I. & Nakajima, K. 2015 Jul 1 In : Neuroscience Research. 96, p. 30-36 7 p.

Research output: Contribution to journalArticle

Sensory Gating
Phencyclidine
Prefrontal Cortex
GABAergic Neurons
Lateral Ventricles
26 Citations

Reelin receptors ApoER2 and VLDLR are expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex

Hirota, Y., Kubo, K. I., Katayama, K. I., Honda, T., Fujino, T., Yamamoto, T. T. & Nakajima, K. 2015 Feb 15 In : Journal of Comparative Neurology. 523, 3, p. 463-478 16 p.

Research output: Contribution to journalArticle

Cerebral Cortex
Neurons
Neocortex
Glycoproteins
Monoclonal Antibodies
9 Citations

The COUP-TFII/neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain

Kanatani, S., Honda, T., Aramaki, M., Hayashi, K., Kubo, K. I., Ishida, M., Tanaka, D. H., Kawauchi, T., Sekine, K., Kusuzawa, S., Kawasaki, T., Hirata, T., Tabata, H., Uhlén, P. & Nakajima, K. 2015 Sep 8 In : Proceedings of the National Academy of Sciences of the United States of America. 112, 36, p. E4985-E4994

Research output: Contribution to journalArticle

COUP Transcription Factor II
Neuropilin-2
GABAergic Neurons
Diencephalon
Preoptic Area
2014
22 Citations

Hippocampal pyramidal neurons switch from a multipolar migration mode to a novel "climbing" migration mode during development

Kitazawa, A., Kubo, K. I., Hayashi, K., Matsunaga, Y., Ishii, K. & Nakajima, K. 2014 In : Journal of Neuroscience. 34, 4, p. 1115-1126 12 p.

Research output: Contribution to journalArticle

Pyramidal Cells
Hippocampus
Neocortex
Neurons
Time-Lapse Imaging
44 Citations

How does Reelin control neuronal migration and layer formation in the developing mammalian neocortex?

Sekine, K., Kubo, K. I. & Nakajima, K. 2014 Sep 1 In : Neuroscience Research. 86, p. 50-58 9 p.

Research output: Contribution to journalArticle

Neocortex
Parturition
Neurons
Adhesiveness
Cell Polarity
2013
4 Citations

Dab1-mediated colocalization of multi-adaptor protein CIN85 with Reelin receptors, ApoER2 and VLDLR, in neurons

Fuchigami, T., Sato, Y., Tomita, Y., Takano, T., Miyauchi, S. Y., Tsuchiya, Y., Saito, T., Kubo, K. I., Nakajima, K., Fukuda, M., Hattori, M. & Hisanaga, S. I. 2013 May In : Genes to Cells. 18, 5, p. 410-424 15 p.

Research output: Contribution to journalArticle

Neurons
Phosphorylation
Proteins
Endosomes
Receptor Protein-Tyrosine Kinases
2 Citations

Neuronal distribution in the cerebral cortex and its significance in schizophrenia

Kubo, K. I. & Nakajima, K. 2013 Oct In : Brain and Nerve. 65, 10, p. 1133-1145 13 p.

Research output: Contribution to journalArticle

Cerebral Cortex
Schizophrenia
Neocortex
Brain
Psychotic Disorders
2012
74 Citations

Reelin Controls Neuronal Positioning by Promoting Cell-Matrix Adhesion via Inside-Out Activation of Integrin α5β1

Sekine, K., Kawauchi, T., Kubo, K. I., Honda, T., Herz, J., Hattori, M., Kinashi, T. & Nakajima, K. 2012 Oct 18 In : Neuron. 76, 2, p. 353-369 17 p.

Research output: Contribution to journalArticle

Cell-Matrix Junctions
Integrins
Fibronectins
Neocortex
Extracellular Matrix
2011
125 Citations

DISC1-dependent switch from progenitor proliferation to migration in the developing cortex

Ishizuka, K., Kamiya, A., Oh, E. C., Kanki, H., Seshadri, S., Robinson, J. F., Murdoch, H., Dunlop, A. J., Kubo, K. I., Furukori, K., Huang, B., Zeledon, M., Hayashi-Takagi, A., Okano, H., Nakajima, K., Houslay, M. D., Katsanis, N. & Sawa, A. 2011 May 5 In : Nature. 473, 7345, p. 92-96 5 p.

Research output: Contribution to journalArticle

Phosphorylation
Serine
Stem Cells
Bardet-Biedl Syndrome
Centrosome
38 Citations

Disrupted-in-schizophrenia-1 (Disc1) is necessary for migration of the pyramidal neurons during mouse hippocampal development

Tomita, K., Kubo, K. I., Ishii, K. & Nakajima, K. 2011 Jul In : Human Molecular Genetics. 20, 14, p. 2834-2845 12 p., ddr194

Research output: Contribution to journalArticle

Pyramidal Cells
Schizophrenia
Hippocampus
Psychiatry
RNA Interference
40 Citations

GABAergic precursor transplantation into the prefrontal cortex prevents phencyclidine-induced cognitive deficits

Tanaka, D. H., Toriumi, K., Kubo, K. I., Nabeshima, T. & Nakajima, K. 2011 Oct 5 In : Journal of Neuroscience. 31, 40, p. 14116-14125 10 p.

Research output: Contribution to journalArticle

Phencyclidine
Interneurons
Prefrontal Cortex
Median Eminence
Transplantation
4 Citations

Reelin inhibits migration of sympathetic preganglionic neurons in the spinal cord of the chick

Yip, Y. P., Zhou, G., Kubo, K. I., Nakajima, K. & Yip, J. W. 2011 Jul 1 In : Journal of Comparative Neurology. 519, 10, p. 1970-1978 9 p.

Research output: Contribution to journalArticle

Spinal Cord
Neurons
Efferent Pathways
Electroporation
Motor Neurons
58 Citations
Neocortex
Cerebral Cortex
Neurons
Locomotion
Electroporation
2010
45 Citations

Ectopic reelin induces neuronal aggregation with a normal birthdate-dependent "inside-out" alignment in the developing neocortex

Kubo, K. I., Honda, T., Tomita, K., Sekine, K., Ishii, K., Uto, A., Kobayashi, K., Tabata, H. & Nakajima, K. 2010 Aug 18 In : Journal of Neuroscience. 30, 33, p. 10953-10966 14 p.

Research output: Contribution to journalArticle

Neocortex
Neurons
Dendrites
Neurologic Mutant Mice
Cerebral Cortex
184 Citations

Knockdown of DISC1 by In Utero Gene Transfer Disturbs Postnatal Dopaminergic Maturation in the Frontal Cortex and Leads to Adult Behavioral Deficits

Niwa, M., Kamiya, A., Murai, R., Kubo, K. I., Gruber, A. J., Tomita, K., Lu, L., Tomisato, S., Jaaro-Peled, H., Seshadri, S., Hiyama, H., Huang, B., Kohda, K., Noda, Y., O'Donnell, P., Nakajima, K., Sawa, A. & Nabeshima, T. 2010 Feb 25 In : Neuron. 65, 4, p. 480-489 10 p.

Research output: Contribution to journalArticle

Frontal Lobe
Schizophrenia
Brain
Genes
Psychiatry
31 Citations

Migration defects by DISC1 knockdown in C57BL/6, 129X1/SvJ, and ICR strains via in utero gene transfer and virus-mediated RNAi

Kubo, K. I., Tomita, K., Uto, A., Kuroda, K., Seshadri, S., Cohen, J., Kaibuchi, K., Kamiya, A. & Nakajima, K. 2010 Oct 1 In : Biochemical and Biophysical Research Communications. 400, 4, p. 631-637 7 p.

Research output: Contribution to journalArticle

Gene transfer
RNA Interference
Viruses
Small Interfering RNA
Schizophrenia
153 Citations

Rab GTPases-dependent endocytic pathways regulate neuronal migration and maturation through N-cadherin trafficking

Kawauchi, T., Sekine, K., Shikanai, M., Chihama, K., Tomita, K., Kubo, K. I., Nakajima, K., Nabeshima, Y. I. & Hoshino, M. 2010 In : Neuron. 67, 4, p. 588-602 15 p.

Research output: Contribution to journalArticle

rab GTP-Binding Proteins
Cadherins
Dynamins
Electroporation
Membranes
2008
92 Citations

Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: A candidate for psychiatric illnesses

Kamiya, A., Tan, P. L., Kubo, K. I., Engelhard, C., Ishizuka, K., Kubo, A., Tsukita, S., Pulver, A. E., Nakajima, K., Cascella, N. G., Katsanis, N. & Sawa, A. 2008 Sep In : Archives of General Psychiatry. 65, 9, p. 996-1006 11 p.

Research output: Contribution to journalArticle

Centrosome
Staphylococcal Protein A
Psychiatry
Schizophrenia
Proteins
2007
16 Citations

Regulation of the interaction of Disabled-1 with CIN85 by phosphorylation with Cyclin-dependent kinase 5

Sato, Y., Taoka, M., Sugiyama, N., Kubo, K. I., Fuchigami, T., Asada, A., Saito, T., Nakajima, K., Isobe, T. & Hisanaga, S. I. 2007 Dec In : Genes to Cells. 12, 12, p. 1315-1327 13 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 5
Phosphorylation
Actins
src Homology Domains
Actin Capping Proteins
2005
333 Citations

A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development

Kamiya, A., Kubo, K. I., Tomoda, T., Takaki, M., Youn, R., Ozeki, Y., Sawamura, N., Park, U., Kudo, C., Okawa, M., Ross, C. A., Hatten, M. E., Nakajima, K. & Sawa, A. 2005 Dec In : Nature Cell Biology. 7, 12, p. 1067-1078 12 p.

Research output: Contribution to journalArticle

Cerebral Cortex
Schizophrenia
Mutation
Dyneins
Centrosome
2003
18 Citations

Cell and molecular mechanisms that control cortical layer formation in the brain

Kubo, K. I. & Nakajima, K. 2003 Mar In : Keio Journal of Medicine. 52, 1, p. 8-20 13 p.

Research output: Contribution to journalArticle

Brain
Cerebral Cortex
Genes
Central Nervous System
Neurons
2002
69 Citations

Secreted Reelin molecules form homodimers

Kubo, K. I., Mikoshiba, K. & Nakajima, K. 2002 In : Neuroscience Research. 43, 4, p. 381-388 8 p.

Research output: Contribution to journalArticle

Dimerization
Proteins
Phosphorylation
Extracellular Matrix Proteins
Protein Binding
2000
100 Citations

Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody

Utsunomiya-Tate, N., Kubo, K. I., Tate, S. I., Kainosho, M., Katayama, E., Nakajima, K. & Mikoshiba, K. 2000 Aug 15 In : Proceedings of the National Academy of Sciences of the United States of America. 97, 17, p. 9729-9734 6 p.

Research output: Contribution to journalArticle

Epitopes
Antibodies
Proteins
Blocking Antibodies
Static Electricity
1999
92 Citations

Pax-6 is required for thalamocortical pathway formation in fetal rats

Kawano, H., Fukuda, T., Kubo, K., Horie, M., Uyemura, K., Takeuchi, K., Osumi, N., Eto, K. & Kawamura, K. 1999 May 31 In : Journal of Comparative Neurology. 408, 2, p. 147-160 14 p.

Research output: Contribution to journalArticle

Thalamus
Axons
Fetus
Neuronal Cell Adhesion Molecules
Neural Cell Adhesion Molecule L1