• 4843 Citations
  • 36 h-Index
20002020

Research output per year

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Research Output

2020

Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model

Abe, Y., Ikegawa, N., Yoshida, K., Muramatsu, K., Hattori, S., Kawai, K., Murakami, M., Tanaka, T., Goda, W., Goto, M., Yamamoto, T., Hashimoto, T., Yamada, K., Shibata, T., Misawa, H., Mimura, M., Tanaka, K. F., Miyakawa, T., Iwatsubo, T., Hata, J. I. & 2 others, Niikura, T. & Yasui, M., 2020 May 12, In : Acta Neuropathologica Communications. 8, 1, 67.

Research output: Contribution to journalArticle

Open Access

Compartmentalized Input–Output Organization of Lugaro Cells in the Cerebellar Cortex

Miyazaki, T., Yamasaki, M., Tanaka, K. F. & Watanabe, M., 2020, (Accepted/In press) In : Neuroscience.

Research output: Contribution to journalArticle

Different roles of distinct serotonergic pathways in anxiety-like behavior, antidepressant-like, and anti-impulsive effects

Ohmura, Y., Tsutsui-Kimura, I., Sasamori, H., Nebuka, M., Nishitani, N., Tanaka, K. F., Yamanaka, A. & Yoshioka, M., 2020 May 1, In : Neuropharmacology. 167, 107703.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Essential role of microglial transforming growth factor-β1 in antidepressant actions of (R)-ketamine and the novel antidepressant TGF-β1

Zhang, K., Yang, C., Chang, L., Sakamoto, A., Suzuki, T., Fujita, Y., Qu, Y., Wang, S., Pu, Y., Tan, Y., Wang, X., Ishima, T., Shirayama, Y., Hatano, M., Tanaka, K. F. & Hashimoto, K., 2020 Dec 1, In : Translational psychiatry. 10, 1, 32.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Identification of Lacrimal Gland Postganglionic Innervation and Its Regulation of Tear Secretion

Jin, K., Imada, T., Hisamura, R., Ito, M., Toriumi, H., Tanaka, K. F., Nakamura, S. & Tsubota, K., 2020 May, In : American Journal of Pathology. 190, 5, p. 1068-1079 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Opposing Ventral Striatal Medium Spiny Neuron Activities Shaped by Striatal Parvalbumin-Expressing Interneurons during Goal-Directed Behaviors

Yoshida, K., Tsutsui-Kimura, I., Kono, A., Yamanaka, A., Kobayashi, K., Watanabe, M., Mimura, M. & Tanaka, K. F., 2020 Jun 30, In : Cell Reports. 31, 13, 107829.

Research output: Contribution to journalArticle

Open Access
2019

AppNL-G-F/NL-G-F mice overall do not show impaired motivation, but cored amyloid plaques in the striatum are inversely correlated with motivation

Hamaguchi, T., Tsutsui-Kimura, I., Mimura, M., Saito, T., Saido, T. C. & Tanaka, K. F., 2019 Oct, In : Neurochemistry International. 129, 104470.

Research output: Contribution to journalArticle

Detection of a High-Turnover Serotonin Circuit in the Mouse Brain Using Mass Spectrometry Imaging

Sugiyama, E., Guerrini, M. M., Honda, K., Hattori, Y., Abe, M., Källback, P., Andrén, P. E., Tanaka, K. F., Setou, M., Fagarasan, S., Suematsu, M. & Sugiura, Y., 2019 Oct 25, In : iScience. 20, p. 359-372 14 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Enriched environment alleviates stress-induced dry-eye through the BDNF axis

Sano, K., Kawashima, M., Imada, T., Suzuki, T., Nakamura, S., Mimura, M., Tanaka, K. & Tsubota, K., 2019 Dec 1, In : Scientific reports. 9, 1, 3422.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Loss of Adult 5-HT1A Autoreceptors Results in a Paradoxical Anxiogenic Response to Antidepressant Treatment

Turcotte-Cardin, V., Vahid-Ansari, F., Luckhart, C., Daigle, M., Geddes, S. D., Tanaka, K., Hen, R., James, J., Merali, Z., Béïque, J. C. & Albert, P. R., 2019 Feb 20, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 8, p. 1334-1346 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Mechanical regulation of oligodendrocyte morphology and maturation by the mechanosensor p130Cas

Shimizu, T., Osanai, Y., Tanaka, K. F., Thai, T. Q., Abe, M., Natsume, R., Sakimura, K. & Ikenaka, K., 2019 Jul, In : Journal of Neurochemistry. 150, 2, p. 158-172 15 p.

Research output: Contribution to journalArticle

Region- and cell type-specific facilitation of synaptic function at destination synapses induced by oligodendrocyte depolarization

Yamazaki, Y., Abe, Y., Shibata, S., Shindo, T., Fujii, S., Ikenaka, K. & Tanaka, K. F., 2019 May 22, In : Journal of Neuroscience. 39, 21, p. 4036-4050 15 p.

Research output: Contribution to journalArticle

Serotonin-mediated inhibition of ventral hippocampus is required for sustained goal-directed behavior

Yoshida, K., Drew, M. R., Mimura, M. & Tanaka, K., 2019 May 1, In : Nature Neuroscience. 22, 5, p. 770-777 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The physiology and pathophysiology of basal ganglia: From signal transduction to circuits

Chuhma, N., Tanaka, K. F. & Nagai, T., 2019 Dec, In : Neurochemistry International. 131, 104544.

Research output: Contribution to journalEditorial

Translational approach to apathy-like behavior in mice: From the practical point of view

Tanaka, K. & Hamaguchi, T., 2019 Jan 1, (Accepted/In press) In : Psychiatry and Clinical Neurosciences.

Research output: Contribution to journalReview article

1 Citation (Scopus)
2018

5-HT3 antagonists decrease discounting rate without affecting sensitivity to reward magnitude in the delay discounting task in mice

Mori, M., Tsutsui-Kimura, I., Mimura, M. & Tanaka, K., 2018 Jun 28, (Accepted/In press) In : Psychopharmacology. p. 1-11 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Aberrant astrocyte Ca2+ signals “AxCa signals” exacerbate pathological alterations in an Alexander disease model

Saito, K., Shigetomi, E., Yasuda, R., Sato, R., Nakano, M., Tashiro, K., Tanaka, K. F., Ikenaka, K., Mikoshiba, K., Mizuta, I., Yoshida, T., Nakagawa, M., Mizuno, T. & Koizumi, S., 2018 May, In : Glia. 66, 5, p. 1053-1067 15 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes

Kinoshita, M., Hirayama, Y., Fujishita, K., Shibata, K., Shinozaki, Y., Shigetomi, E., Takeda, A., Le, H. P. N., Hayashi, H., Hiasa, M., Moriyama, Y., Ikenaka, K., Tanaka, K. F. & Koizumi, S., 2018 Jun, In : EBioMedicine. 32, p. 72-83 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

A three-dimensional single-cell-resolution whole-brain atlas using CUBIC-X expansion microscopy and tissue clearing

Murakami, T. C., Mano, T., Saikawa, S., Horiguchi, S. A., Shigeta, D., Baba, K., Sekiya, H., Shimizu, Y., Tanaka, K., Kiyonari, H., Iino, M., Mochizuki, H., Tainaka, K. & Ueda, H. R., 2018 Mar 5, (Accepted/In press) In : Nature Neuroscience. p. 1-13 13 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Calcium Transient Dynamics of Neural Ensembles in the Primary Motor Cortex of Naturally Behaving Monkeys

Kondo, T., Saito, R., Otaka, M., Yoshino-Saito, K., Yamanaka, A., Yamamori, T., Watakabe, A., Mizukami, H., Schnitzer, M. J., Tanaka, K. F., Ushiba, J. & Okano, H., 2018 Aug 21, In : Cell Reports. 24, 8, p. 2191-2195.e4

Research output: Contribution to journalArticle

6 Citations (Scopus)

Cathepsin C modulates myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis

Durose, W. W., Shimizu, T., Li, J. Y., Abe, M., Sakimura, K., Chetsawang, B., Tanaka, K., Suzumura, A., Tohyama, K. & Ikenaka, K., 2018 Jan 1, (Accepted/In press) In : Journal of Neurochemistry.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents

Tainaka, K., Murakami, T. C., Susaki, E. A., Shimizu, C., Saito, R., Takahashi, K., Hayashi-Takagi, A., Sekiya, H., Arima, Y., Nojima, S., Ikemura, M., Ushiku, T., Shimizu, Y., Murakami, M., Tanaka, K. F., Iino, M., Kasai, H., Sasaoka, T., Kobayashi, K., Miyazono, K. & 5 others, Morii, E., Isa, T., Fukayama, M., Kakita, A. & Ueda, H. R., 2018 Aug 21, In : Cell Reports. 24, 8, p. 2196-2210.e9

Research output: Contribution to journalArticle

34 Citations (Scopus)

Ectopic positioning of Bergmann glia and impaired cerebellar wiring in Mlc1-over-expressing mice

Kikuchihara, S., Sugio, S., Tanaka, K. F., Watanabe, T., Kano, M., Yamazaki, Y., Watanabe, M. & Ikenaka, K., 2018 Nov, In : Journal of Neurochemistry. 147, 3, p. 344-360 17 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships

Zhang, P., Lu, H., Peixoto, R. T., Pines, M. K., Ge, Y., Oku, S., Siddiqui, T. J., Xie, Y., Wu, W., Archer-Hartmann, S., Yoshida, K., Tanaka, K. F., Aricescu, A. R., Azadi, P., Gordon, M. D., Sabatini, B. L., Wong, R. O. L. & Craig, A. M., 2018 Sep 6, In : Cell. 174, 6, p. 1450-1464.e23

Research output: Contribution to journalArticle

27 Citations (Scopus)

Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics

Chen, S., Weitemier, A. Z., Zeng, X., He, L., Wang, X., Tao, Y., Huang, A. J. Y., Hashimotodani, Y., Kano, M., Iwasaki, H., Parajuli, L. K., Okabe, S., Loong Teh, D. B., All, A. H., Tsutsui-Kimura, I., Tanaka, K. F., Liu, X. & McHugh, T. J., 2018 Feb 9, In : Science. 359, 6376, p. 679-684 6 p.

Research output: Contribution to journalArticle

265 Citations (Scopus)

Neuroprotective effects of microglial P2Y1 receptors against ischemic neuronal injury

Fukumoto, Y., Tanaka, K., Parajuli, B., Shibata, K., Yoshioka, H., Kanemaru, K., Gachet, C., Ikenaka, K., Koizumi, S. & Kinouchi, H., 2018 Jan 1, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Optogenetic astrocyte activation evokes BOLD fMRI response with oxygen consumption without neuronal activity modulation

Takata, N., Sugiura, Y., Yoshida, K., Koizumi, M., Hiroshi, N., Honda, K., Yano, R., Komaki, Y., Matsui, K., Suematsu, M., Mimura, M., Okano, H. & Tanaka, K. F., 2018 Sep, In : Glia. 66, 9, p. 2013-2023 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Quantitative temporal changes in DTI values coupled with histological properties in cuprizone-induced demyelination and remyelination

Yano, R., Hata, J., Abe, Y., Seki, F., Yoshida, K., Komaki, Y., Okano, H. & Tanaka, K. F., 2018 Oct, In : Neurochemistry International. 119, p. 151-158 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Reward probability and timing uncertainty alter the effect of dorsal raphe serotonin neurons on patience

Miyazaki, K., Miyazaki, K. W., Yamanaka, A., Tokuda, T., Tanaka, K. & Doya, K., 2018 Dec 1, In : Nature Communications. 9, 1, 2048.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Role of purinergic receptor P2Y1 in spatiotemporal Ca2+ dynamics in astrocytes

Shigetomi, E., Hirayama, Y. J., Ikenaka, K., Tanaka, K. & Koizumi, S., 2018 Feb 7, In : Journal of Neuroscience. 38, 6, p. 1383-1395 13 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Visualization of myelinated fiber bundles orientation during brain slice preparation by reflection polarized light microscopy

Takata, N., Kusayanagi, K., Maruyama, H., Eitai, K., Abo, M., Akiyama, F., Tajima, R., Inaba, S., Tanaka, K., Mimura, M. & Sanaka, K., 2018 Jan 1, (Accepted/In press) In : Microscopy Research and Technique.

Research output: Contribution to journalArticle

2017

Abrogated freud-1/Cc2d1a repression of 5-HT1A autoreceptors induces fluoxetine-resistant anxiety/ depression-like behavior

Vahid-Ansari, F., Daigle, M., Manzini, M. C., Tanaka, K., Hen, R., Geddes, S. D., Béïque, J. C., James, J., Merali, Z. & Albert, P. R., 2017 Dec 6, In : Journal of Neuroscience. 37, 49, p. 11967-11978 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Amplitude and frequency feature extraction of neural activity in mouse ventrolateral striatum under different motivational states using fiber photometric system

Imai, S., Mitsukura, Y., Yoshida, K., Tsutsui-Kimura, I., Takata, N. & Tanaka, K. F., 2017 Jul 1, 2017 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc., p. 1-6 6 p. (2017 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2017 - Proceedings; vol. 2018-January).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

A New Paradigm for Evaluating Avoidance/Escape Motivation

Tsutsui-Kimura, I., Bouchekioua, Y., Mimura, M. & Tanaka, K., 2017 Jul 1, In : International Journal of Neuropsychopharmacology. 20, 7, p. 593-601 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Association of impaired neuronal migration with cognitive deficits in extremely preterm infants

Kubo, K. I., Deguchi, K., Nagai, T., Ito, Y., Yoshida, K., Endo, T., Benner, S., Shan, W., Kitazawa, A., Aramaki, M., Ishii, K., Shin, M., Matsunaga, Y., Hayashi, K., Kakeyama, M., Tohyama, C., Tanaka, K. F., Tanaka, K., Takashima, S., Nakayama, M. & 7 others, Itoh, M., Hirata, Y., Antalffy, B., Armstrong, D. D., Yamada, K., Inoue, K. & Nakajima, K., 2017 May 18, In : JCI Insight. 2, 10

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Distinct Roles of Ventromedial versus Ventrolateral Striatal Medium Spiny Neurons in Reward-Oriented Behavior

Tsutsui-Kimura, I., Natsubori, A., Mori, M., Kobayashi, K., Drew, M. R., de Kerchove d'Exaerde, A., Mimura, M. & Tanaka, K. F., 2017 Oct 9, In : Current Biology. 27, 19, p. 3042-3048.e4

Research output: Contribution to journalArticle

8 Citations (Scopus)

Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation

Tsutsui-Kimura, I., Takiue, H., Yoshida, K., Xu, M., Yano, R., Ohta, H., Nishida, H., Bouchekioua, Y., Okano, H., Uchigashima, M., Watanabe, M., Takata, N., Drew, M. R., Sano, H., Mimura, M. & Tanaka, K. F., 2017 Feb 1, In : Nature Communications. 8, 14304.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Hearing loss controlled by optogenetic stimulation of nonexcitable nonglial cells in the cochlea of the inner ear

Sato, M. P., Higuchi, T., Nin, F., Ogata, G., Sawamura, S., Yoshida, T., Ota, T., Hori, K., Komune, S., Uetsuka, S., Choi, S., Masuda, M., Watabe, T., Kanzaki, S., Ogawa, K., Inohara, H., Sakamoto, S., Takebayashi, H., Doi, K., Tanaka, K. F. & 1 others, Hibino, H., 2017 Sep 21, In : Frontiers in Molecular Neuroscience. 10, 300.

Research output: Contribution to journalArticle

1 Citation (Scopus)

High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates

Seiriki, K., Kasai, A., Hashimoto, T., Schulze, W., Niu, M., Yamaguchi, S., Nakazawa, T., Inoue, K. I., Uezono, S., Takada, M., Naka, Y., Igarashi, H., Tanuma, M., Waschek, J. A., Ago, Y., Tanaka, K. F., Hayata-Takano, A., Nagayasu, K., Shintani, N., Hashimoto, R. & 10 others, Kunii, Y., Hino, M., Matsumoto, J., Yabe, H., Nagai, T., Fujita, K., Matsuda, T., Takuma, K., Baba, A. & Hashimoto, H., 2017 Jun 21, In : Neuron. 94, 6, p. 1085-1100.e6

Research output: Contribution to journalArticle

31 Citations (Scopus)

Hippocampal activity during serotonergic neuronal activity manipulation using optogenetics

Kondo, D., Mitsukura, Y., Yoshida, K., Tsutsui-Kimura, I., Takata, N. & Tanaka, K. F., 2017 Jul 1, 2017 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc., p. 1-6 6 p. (2017 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2017 - Proceedings; vol. 2018-January).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Maturation of Cerebellar Purkinje Cell Population Activity during Postnatal Refinement of Climbing Fiber Network

Good, J. M., Mahoney, M., Miyazaki, T., Tanaka, K. F., Sakimura, K., Watanabe, M., Kitamura, K. & Kano, M., 2017 Nov 21, In : Cell Reports. 21, 8, p. 2066-2073 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Mitochondrial DNA double-strand breaks in oligodendrocytes cause demyelination, axonal injury, and CNS inflammation

Madsen, P. M., Pinto, M., Patel, S., McCarthy, S., Gao, H., Taherian, M., Karmally, S., Pereira, C. V., Dvoriantchikova, G., Ivanov, D., Tanaka, K. F., Moraes, C. T. & Brambilla, R., 2017 Oct 18, In : Journal of Neuroscience. 37, 42, p. 10185-10199 15 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

OCD candidate gene SLC1A1/EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior

Zike, I. D., Chohan, M. O., Kopelman, J. M., Krasnow, E. N., Flicker, D., Nautiyal, K. M., Bubser, M., Kellendonk, C., Jones, C. K., Stanwood, G., Tanaka, K. F., Moore, H., Ahmari, S. E. & Veenstra-VanderWeele, J., 2017 May 30, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 22, p. 5719-5724 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Serotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor

Imada, T., Nakamura, S., Hisamura, R., Izuta, Y., Jin, K., Ito, M., Kitamura, N., Tanaka, K. F., Mimura, M., Shibuya, I. & Tsubota, K., 2017 Dec 1, In : Scientific reports. 7, 1, 6965.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Striatonigral direct pathway activation is sufficient to induce repetitive behaviors

Bouchekioua, Y., Tsutsui-Kimura, I., Sano, H., Koizumi, M., Tanaka, K., Yoshida, K., Kosaki, Y., Watanabe, S. & Mimura, M., 2017, (Accepted/In press) In : Neuroscience Research.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The balance between cathepsin C and cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease model

Shimizu, T., Wisessmith, W., Li, J., Abe, M., Sakimura, K., Chetsawang, B., Sahara, Y., Tohyama, K., Tanaka, K. F. & Ikenaka, K., 2017 Jun, In : Glia. 65, 6, p. 917-930 14 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Time-controllable Nkcc1 knockdown replicates reversible hearing loss in postnatal mice

Watabe, T., Xu, M., Watanabe, M., Nabekura, J., Higuchi, T., Hori, K., Sato, M. P., Nin, F., Hibino, H., Ogawa, K., Masuda, M. & Tanaka, K. F., 2017 Dec 1, In : Scientific reports. 7, 1, 13605.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y1 Receptor Downregulation

Shinozaki, Y., Shibata, K., Yoshida, K., Shigetomi, E., Gachet, C., Ikenaka, K., Tanaka, K. & Koizumi, S., 2017 May 9, In : Cell Reports. 19, 6, p. 1151-1164 14 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

Ventrolateral striatal medium spiny neurons positively regulate food-incentive, goal-directed behavior independently of D1 and D2 selectivity

Natsubori, A., Tsutsui-Kimura, I., Nishida, H., Bouchekioua, Y., Sekiya, H., Uchigashima, M., Watanabe, M., De Kerchove D’Exaerde, A., Mimura, M., Takata, N. & Tanaka, K. F., 2017 Mar 8, In : Journal of Neuroscience. 37, 10, p. 2723-2733 11 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)