• 2102 Citations
  • 25 h-Index
19972020

Research output per year

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Research Output

  • 2102 Citations
  • 25 h-Index
  • 81 Article
  • 3 Letter
  • 2 Review article
  • 1 Comment/debate
2020

Characteristics of chronic obstructive pulmonary disease patients with pulmonary hypertension assessed by echocardiography in a three-year observational cohort study

Nakayama, S., Chubachi, S., Sakurai, K., Irie, H., Tsutsumi, A., Hashiguchi, M., Itabashi, Y., Murata, M., Nakamura, H., Asano, K. & Fukunaga, K., 2020 Jan 1, In : International Journal of COPD. 15, p. 487-499 13 p.

Research output: Contribution to journalArticle

Open Access
2019

Allergic bronchopulmonary aspergillosis in succession to chronic eosinophilic pneumonia

Mochimaru, T., Fukunaga, K., Ueda, S., Kuroda, A., Watanabe, R., Chubachi, S. & Betsuyaku, T., 2019 Jul 1, In : Allergology International. 68, 3, p. 370-371 2 p.

Research output: Contribution to journalLetter

Open Access

A novel smoking cessation smartphone app integrated with a mobile carbon monoxide checker for smoking cessation treatment: Protocol for a randomized controlled trial

Nomura, A., Tateno, H., Masaki, K., Muto, T., Suzuki, S., Satake, K., Hida, E. & Fukunaga, K., 2019 Feb 1, In : Journal of medical Internet research. 21, 2, e12252.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Current state and future prospect of the therapeutic strategy targeting cysteinyl leukotriene metabolism in asthma

Yamamoto, T., Miyata, J., Arita, M., Fukunaga, K. & Kawana, A., 2019 Nov, In : Respiratory Investigation. 57, 6, p. 534-543 10 p.

Research output: Contribution to journalReview article

Cysteinyl leukotriene metabolism of human eosinophils in allergic disease

Miyata, J., Fukunaga, K., Kawashima, Y., Ohara, O. & Arita, M., 2019 Jan 1, In : Allergology International.

Research output: Contribution to journalReview article

Open Access

Deficiency of CRTH2, a prostaglandin D 2 receptor, aggravates bleomycin-induced pulmonary inflammation and fibrosis

Ueda, S., Fukunaga, K., Takihara, T., Shiraishi, Y., Oguma, T., Shiomi, T., Suzuki, Y., Ishii, M., Sayama, K., Kagawa, S., Hirai, H., Nagata, K., Nakamura, M., Miyasho, T., Betsuyaku, T. & Asano, K., 2019 Mar 1, In : American journal of respiratory cell and molecular biology. 60, 3, p. 289-298 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Dysregulated fatty acid metabolism in nasal polyp-derived eosinophils from patients with chronic rhinosinusitis

Miyata, J., Fukunaga, K., Kawashima, Y., Watanabe, T., Saitoh, A., Hirosaki, T., Araki, Y., Kikawada, T., Betsuyaku, T., Ohara, O. & Arita, M., 2019 Jan 1, In : Allergy: European Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Evaluating serum periostin levels in allergic bronchopulmonary aspergillosis

Tanaka, J., Hebisawa, A., Oguma, T., Tomomatsu, K., Suzuki, J., Shimizu, H., Kawabata, Y., Ishiguro, T., Takayanagi, N., Ueda, S., Fukunaga, K., Taniguchi, M., Ono, J., Ohta, S., Izuhara, K. & Asano, K., 2019 Jan 1, (Accepted/In press) In : Allergy: European Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalLetter

Factors associated with improvements in subjective symptoms of obstructive sleep apnea syndrome after continuous positive airway pressure therapy

Otsuka, K., Fukunaga, K., WakakoYamasawa, Haraguchi, M., Tani, T., Shirahama, R. & Betsuyaku, T., 2019 Jan 1, In : Sleep and Breathing.

Research output: Contribution to journalArticle

Impact of a novel smartphone app (cureapp smoking cessation) on nicotine dependence: Prospective single-arm interventional pilot study

Masaki, K., Tateno, H., Kameyama, N., Morino, E., Watanabe, R., Sekine, K., Ono, T., Satake, K., Suzuki, S., Nomura, A., Betsuyaku, T. & Fukunaga, K., 2019 Feb 1, In : Journal of medical Internet research. 21, 2, e12694.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

MULTIOMICS ANALYSIS OF HUMAN EOSINOPHILS REVEALED MOLECULAR MECHANISM OF EOSINOPHILIC RHINOSINUSITIS AND SEVERE ASTHMA

Miyata, J., Kawashima, Y., Ohara, O., Betsuyaku, T., Fukunaga, K. & Arita, M., 2019 Jan 1, In : Arerugi = [Allergy]. 68, 2, p. 86-91 6 p.

Research output: Contribution to journalArticle

Neutrophil-to-lymphocyte ratio as a novel independent predictor of severe exacerbation in patients with asthma

Mochimaru, T., Ueda, S., Suzuki, Y., Asano, K. & Fukunaga, K., 2019 Jan 1, (Accepted/In press) In : Annals of Allergy, Asthma and Immunology.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Predictive and modifying factors of bone mineral density decline in patients with COPD

Kameyama, N., Chubachi, S., Sasaki, M., Tsutsumi, A., Irie, H., Sakurai, K., Sayama, K., Nakamura, H., Asano, K., Betsuyaku, T. & Fukunaga, K., 2019 Mar 1, In : Respiratory Medicine. 148, p. 13-23 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Rare presentation of anaphylaxis: Pancake syndrome

Masaki, K., Fukunaga, K., Kawakami, Y. & Haque, R., 2019 Mar 1, In : BMJ case reports. 12, 3, e228854.

Research output: Contribution to journalArticle

Sleep stage detection using only heart rate

Mitsukura, Y., Fukunaga, K., Yasui, M. & Mimura, M., 2019 Jan 1, In : Health Informatics Journal.

Research output: Contribution to journalArticle

2018

Association between severity of obstructive sleep apnea and glycated hemoglobin level in japanese individuals with and without diabetes

Kurosawa, H., Saisho, Y., Fukunaga, K., Haraguchi, M., Yamasawa, W., Kurihara, I., Betsuyaku, T. & Itoh, H., 2018 Jan 1, In : Endocrine Journal. 65, 1, p. 121-127 7 p.

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Author's reply: Atrial fibrillation and sleep apnea: A chicken and egg situation

Kimura, T., Kohno, T., Fukunaga, K., Yamasawa, W., Fujisawa, T., Fukuoka, R., Nakajima, K., Kashimura, S., Kunitomi, A., Katsumata, Y., Nishiyama, T., Nishiyama, N., Aizawa, Y., Fukuda, K. & Takatsuki, S., 2018 Nov 1, In : International Journal of Cardiology. 270, 1 p.

Research output: Contribution to journalLetter

Development of necrotizing myopathy following interstitial lung disease with anti-signal recognition particle antibody

Kusumoto, T., Okamori, S., Masuzawa, K., Asakura, T., Nishina, N., Chubachi, S., Naoki, K., Fukunaga, K. & Betsuyaku, T., 2018 Jan 1, In : Internal Medicine. 57, 14, p. 2045-2049 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Eosinophils and anti-inflammatory lipid mediators

Fukunaga, K., 2018 Jan 1, In : Japanese Journal of Allergology. 67, 1, p. 28-30 3 p.

Research output: Contribution to journalArticle

Intermittent exposure to cigarette smoke increases lung tumors and the severity of emphysema more than continuous exposure

Kameyama, N., Chubachi, S., Hegab, A. E., Yasuda, H., Kagawa, S., Tsutsumi, A., Fukunaga, K., Shimoda, M., Kanai, Y., Soejima, K. & Betsuyaku, T., 2018 Aug 1, In : American Journal of Respiratory Cell and Molecular Biology. 59, 2, p. 179-188 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Prevalence and clinical characteristics of obstructive- and central-dominant sleep apnea in candidates of catheter ablation for atrial fibrillation in Japan

Kohno, T., Kimura, T., Fukunaga, K., Yamasawa, W., Fujisawa, T., Fukuoka, R., Nakajima, K., Kashimura, S., Kunitomi, A., Katsumata, Y., Nishiyama, T., Nishiyama, N., Aizawa, Y., Fukuda, K. & Takatsuki, S., 2018 Jun 1, In : International Journal of Cardiology. 260, p. 99-102 4 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Successful Steroid Therapy for Lipoid Pneumonia Developing After Allogeneic Hematopoietic Stem Cell Transplant: A Case Report

Sakurai, M., Kato, J., Toyama, T., Hashida, R., Yamane, Y., Abe, R., Koda, Y., Kohashi, S., Kikuchi, T., Hayashi, Y., Nukaga, S., Ueda, S., Fukunaga, K., Okamoto, S. & Mori, T., 2018 Dec 1, In : Transplantation Proceedings. 50, 10, p. 4096-4098 3 p.

Research output: Contribution to journalArticle

2017

12-OH-17,18-Epoxyeicosatetraenoic acid alleviates eosinophilic airway inflammation in murine lungs

Mochimaru, T., Fukunaga, K., Miyata, J., Matsusaka, M., Masaki, K., Kabata, H., Ueda, S., Suzuki, Y., Goto, T., Urabe, D., Inoue, M., Isobe, Y., Arita, M. & Betsuyaku, T., 2017, (Accepted/In press) In : Allergy: European Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Characteristics of severe asthma with fungal sensitization

Masaki, K., Fukunaga, K., Matsusaka, M., Kabata, H., Tanosaki, T., Mochimaru, T., Kamatani, T., Ohtsuka, K., Baba, R., Ueda, S., Suzuki, Y., Sakamaki, F., Oyamada, Y., Inoue, T., Oguma, T., Sayama, K., Koh, H., Nakamura, M., Umeda, A., Kamei, K. & 3 others, Izuhara, K., Asano, K. & Betsuyaku, T., 2017, (Accepted/In press) In : Annals of Allergy, Asthma and Immunology.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Construction of a system using a deep learning algorithm to count cell numbers in nanoliter wells for viable single-cell experiments

Kamatani, T., Fukunaga, K., Miyata, K., Shirasaki, Y., Tanaka, J., Baba, R., Matsusaka, M., Kamatani, N., Moro, K., Betsuyaku, T. & Uemura, S., 2017 Dec 1, In : Scientific Reports. 7, 1, 16831.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Subphenotypes of type 2 severe asthma in adults

Matsusaka, M., Fukunaga, K., Kabata, H., Izuhara, K., Asano, K. & Betsuyaku, T., 2017, (Accepted/In press) In : Journal of Allergy and Clinical Immunology: In Practice.

Research output: Contribution to journalArticle

8 Citations (Scopus)

The alpha-lipoic acid derivative DHLHZn: a new therapeutic agent for acute lung injury in vivo

Shoji, Y., Takeuchi, H., Fukuda, K., Fukunaga, K., Nakamura, R., Takahashi, T., Wada, N., Kawakubo, H., Miyasho, T., Hiratsuka, T., Inomata, M., Betsuyaku, T. & Kitagawa, Y., 2017 Jun 1, (Accepted/In press) In : Inflammation Research. p. 1-9 9 p.

Research output: Contribution to journalArticle

2016

Allergic bronchopulmonary aspergillosis in Japan: A nationwide survey

Oguma, T., Taniguchi, M., Shimoda, T., Kamei, K., Matsuse, H., Hebisawa, A., Takayanagi, N., Konno, S., Fukunaga, K., Harada, K., Tanaka, J., Tomomatsu, K. & Asano, K., 2016 Dec 26, (Accepted/In press) In : Allergology International.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Erratum: Distinct effects of endogenous interleukin-23 on eosinophilic airway inflammation in response to different antigens (Allergology International (2015) 64 (S24-S29))

Ogawa, R., Suzuki, Y., Kagawa, S., Masaki, K., Fukunaga, K., Yoshimura, A., Fujishima, S., Terashima, T., Betsuyaku, T. & Asano, K., 2016 Jan 1, In : Allergology International. 65, 1, p. 120 1 p.

Research output: Contribution to journalArticle

Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses

Moro, K., Kabata, H., Tanabe, M., Koga, S., Takeno, N., Mochizuki, M., Fukunaga, K., Asano, K., Betsuyaku, T. & Koyasu, S., 2016 Jan 1, In : Nature Immunology. 17, 1, p. 76-86 11 p.

Research output: Contribution to journalArticle

170 Citations (Scopus)

Obstructive sleep apnea syndrome should be considered as a cause of nocturia in younger patients without other voiding symptoms

Maeda, T., Fukunaga, K., Nagata, H., Haraguchi, M., Kikuchi, E., Miyajima, A., Yamasawa, W., Shirahama, R., Narita, M., Betsuyaku, T., Asano, K. & Oya, M., 2016, In : Journal of the Canadian Urological Association. 10, 7-8, p. E241-E245

Research output: Contribution to journalArticle

6 Citations (Scopus)
2015

Attenuation of lipopolysaccharide-induced acute lung injury after (pro)renin receptor blockade

Ishii, K., Takeuchi, H., Fukunaga, K., Hirano, Y., Suda, K., Hagiwara, T., Miyasho, T., Yamada, S., Nakamura, R., Takahashi, T., Wada, N., Kawakubo, H., Saikawa, Y., Omori, T., Betsuyaku, T., Ichihara, A. & Kitagawa, Y., 2015 May 1, In : Experimental Lung Research. 41, 4, p. 199-207 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Determinants of long-term persistence with tiotropium bromide for chronic obstructive pulmonary disease

Tanaka, K., Kamiishi, N., Miyata, J., Kabata, H., Masaki, K., Ogura-Tomomatsu, H., Tomomatsu, K., Suzuki, Y., Fukunaga, K., Sayama, K., Betsuyaku, T. & Asano, K., 2015 May 4, In : COPD: Journal of Chronic Obstructive Pulmonary Disease. 12, 3, p. 233-239 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Distinct effects of endogenous interleukin-23 on eosinophilic airway inflammation in response to different antigens

Ogawa, R., Suzuki, Y., Kagawa, S., Masaki, K., Fukunaga, K., Yoshimura, A., Fujishima, S., Terashima, T., Betsuyaku, T. & Asano, K., 2015 Jan 4, (Accepted/In press) In : Allergology International.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Fatal fulminant pneumonia caused by methicillin-sensitive staphylococcus aureus negative for major high-virulence factors following influenza B virus infection

Masaki, K., Ishii, M., Anraku, M., Namkoong, H., Miyakawa, R., Nakajima, T., Fukunaga, K., Naoki, K., Tasaka, S., Soejima, K., Sayama, K., Sugita, K., Iwata, S., Cui, L., Hanaki, H., Hasegawa, N. & Betsuyaku, T., 2015 Jul 14, In : American Journal of Case Reports. 16, p. 454-458 5 p.

Research output: Contribution to journalArticle

Immune reconstitution inflammatory syndrome due to Mycobacterium avium complex successfully followed up using <sup>18</sup> F-fluorodeoxyglucose positron emission tomography-computed tomography in a patient with human immunodeficiency virus infection: A case report

Namkoong, H., Fujiwara, H., Ishii, M., Yagi, K., Haraguchi, M., Matsusaka, M., Suzuki, S., Asakura, T., Asami, T., Saito, F., Fukunaga, K., Tasaka, S., Betsuyaku, T. & Hasegawa, N., 2015 Jul 18, In : BMC Medical Imaging. 15, 1, 24.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Phenotype of asthma related with high serum periostin levels

Matsusaka, M., Kabata, H., Fukunaga, K., Suzuki, Y., Masaki, K., Mochimaru, T., Sakamaki, F., Oyamada, Y., Inoue, T., Oguma, T., Sayama, K., Koh, H., Nakamura, M., Umeda, A., Ono, J., Ohta, S., Izuhara, K., Asano, K. & Betsuyaku, T., 2015 Apr 1, In : Allergology International. 64, 2, p. 175-180 6 p., 5.

Research output: Contribution to journalArticle

67 Citations (Scopus)

The reasons for triple therapy in stable COPD patients in Japanese clinical practice

Miyazaki, M., Nakamura, H., Takahashi, S., Chubachi, S., Sasaki, M., Haraguchi, M., Terai, H., Ishii, M., Fukunaga, K., Tasaka, S., Soejima, K., Asano, K. & Betsuyaku, T., 2015 Jun 4, In : International Journal of COPD. 10, p. 1053-1059 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2014

Combination therapy of 15-epi-lipoxin a4 with antibiotics protects mice from escherichia coli-induced sepsis

Ueda, T., Fukunaga, K., Seki, H., Miyata, J., Arita, M., Miyasho, T., Obata, T., Asano, K., Betsuyaku, T. & Takeda, J., 2014 Apr, In : Critical care medicine. 42, 4, p. e288-e295

Research output: Contribution to journalArticle

20 Citations (Scopus)

Dual role of interleukin-23 in epicutaneously-sensitized asthma in mice

Masaki, K., Suzuki, Y., Kagawa, S., Kodama, M., Kabata, H., Miyata, J., Tanaka, K., Fukunaga, K., Sayama, K., Oguma, T., Kimura, T., Amagai, M., Betsuyaku, T. & Asano, K., 2014, In : Allergology International. 63, SUPPL. 1, p. 13-22 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

HIRA-TAN: A real-time PCR-based system for the rapid identification of causative agents in pneumonia

Hirama, T., Minezaki, S., Yamaguchi, T., Kishi, E., Kodama, K., Egashira, H., Kobayashi, K., Nagata, M., Ishii, T., Nemoto, M., Tanaka, M., Fukunaga, K., Kanazawa, M. & Hagiwara, K., 2014 Feb 1, In : Respiratory Medicine. 108, 2, p. 395-404 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

The mechanism of airway hyperresponsiveness by lipid mediators

Fukunaga, K., 2014 Jan 1, In : Japanese Journal of Allergology. 63, 6, p. 754-757 4 p.

Research output: Contribution to journalArticle

2013

[Case report; A case of acute respiratory failure following influenza virus infection successfully treated by direct hemoperfusion using a polymyxin B immobilized fiber column].

Arai, D., Fukunaga, K., Fujii, K., Namkoong, H., Haraguchi, M., Funatsu, Y., Naoki, K., Tasaka, S. & Betsuyaku, T., 2013 Feb 10, In : Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine. 102, 2, p. 429-432 4 p.

Research output: Contribution to journalArticle

Open Access

Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma

Miyata, J., Fukunaga, K., Iwamoto, R., Isobe, Y., Niimi, K., Takamiya, R., Takihara, T., Tomomatsu, K., Suzuki, Y., Oguma, T., Sayama, K., Arai, H., Betsuyaku, T., Arita, M. & Asano, K., 2013 Feb, In : Journal of Allergy and Clinical Immunology. 131, 2, p. 353-360.e2

Research output: Contribution to journalArticle

67 Citations (Scopus)

Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation

Kabata, H., Moro, K., Fukunaga, K., Suzuki, Y., Miyata, J., Masaki, K., Betsuyaku, T., Koyasu, S. & Asano, K., 2013 Oct 25, In : Nature communications. 4, 2675.

Research output: Contribution to journalArticle

Open Access
144 Citations (Scopus)
2012

Comparison of two large earthquakes: The 2008 Sichuan earthquake and the 2011 east Japan Earthquake -from a student discussion session in Beijing, 2011

Otani, Y., Ando, T., Atobe, K., Haiden, A., Kao, S. Y., Saito, K., Shimanuki, M., Yoshimoto, N. & Fukunaga, K., 2012 Mar 1, In : Keio Journal of Medicine. 61, 1, p. 35-39 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Increased plasma levels of high mobility group box 1 in patients with acute liver failure

Oshima, G., Shinoda, M., Tanabe, M., Ebinuma, H., Nishiyama, R., Takano, K., Yamada, S., Miyasho, T., Masugi, Y., Matsuda, S., Suda, K., Fukunaga, K., Matsubara, K., Hibi, T., Yagi, H., Hayashida, T., Yamagishi, Y., Obara, H., Itano, O., Takeuchi, H. & 5 others, Kawachi, S., Saito, H., Hibi, T., Maruyama, I. & Kitagawa, Y., 2012 Jun 1, In : European Surgical Research. 48, 3, p. 154-162 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Predictors of osteoporosis and vertebral fractures in patients presenting with moderate-to-severe chronic obstructive lung disease

Ogura-Tomomatsu, H., Asano, K., Tomomatsu, K., Miyata, J., Ohmori, N., Kodama, M., Ueda, S., Takihara, T., Tanaka, K., Kamiishi, N., Suzuki, Y., Fukunaga, K., Oguma, T., Sayama, K. & Betsuyaku, T., 2012 Aug 1, In : COPD: Journal of Chronic Obstructive Pulmonary Disease. 9, 4, p. 332-337 6 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Resolvin E1 maintains macrophage function under cigarette smoke-induced oxidative stress

Takamiya, R., Fukunaga, K., Arita, M., Miyata, J., Seki, H., Minematsu, N., Suematsu, M. & Asano, K., 2012 Oct 25, In : FEBS Open Bio. 2, p. 328-333 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2011

Induction of Mucin and MUC5AC expression by the protease activity of aspergillus fumigatus in airway epithelial cells

Oguma, T., Asano, K., Tomomatsu, K., Kodama, M., Fukunaga, K., Shiomi, T., Ohmori, N., Ueda, S., Takihara, T., Shiraishi, Y., Sayama, K., Kagawa, S., Natori, Y., Lilly, C. M., Satoh, K., Makimura, K. & Ishizaka, A., 2011 Jul 15, In : Journal of Immunology. 187, 2, p. 999-1005 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)