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Research Output 2014 2019

  • 448 Citations
  • 11 h-Index
  • 23 Article
  • 2 Review article
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Article
2019
1 Citation (Scopus)

Development of an Indigo Naturalis Suppository for Topical Induction Therapy in Patients with Ulcerative Colitis

Yoshimatsu, Y., Naganuma, M., Sugimoto, S., Tanemoto, S., Umeda, S., Fukuda, T., Nomura, E., Yoshida, K., Ono, K., Mutaguchi, M., Nanki, K., Mizuno, S., Mikami, Y., Fukuhara, K., Sujino, T., Takabayashi, K., Ogata, H., Iwao, Y. & Kanai, T., 2019 Jan 1, In : Digestion.

Research output: Contribution to journalArticle

Indigo Carmine
Suppositories
Ulcerative Colitis
Therapeutics
Rectum
Colitis
Ulcerative Colitis
Neoplasms
Mucous Membrane
Colectomy
1 Citation (Scopus)

Efficacy of therapeutic intervention for patients with an ulcerative colitis mayo endoscopic score of 1

Fukuda, T., Naganuma, M., Sugimoto, S., Ono, K., Nanki, K., Mizuno, S., Hukuhara, K., Mutaguchi, M., Nakazato, Y., Takabayashi, K., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2019 Mar 14, In : Inflammatory bowel diseases. 25, 4, p. 782-788 7 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Recurrence
Colonoscopy
Therapeutics
Blood Vessels
Cellular Structures
Cadherins
Ulcerative Colitis
Colitis
Signet Ring Cell Carcinoma
2018
24 Citations (Scopus)

Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

Nanki, K., Toshimitsu, K., Takano, A., Fujii, M., Shimokawa, M., Ohta, Y., Matano, M., Seino, T., Nishikori, S., Ishikawa, K., Kawasaki, K., Togasaki, K., Takahashi, S., Sukawa, Y., Ishida, H., Sugimoto, S., Kawakubo, H., Kim, J., Kitagawa, Y., Sekine, S. & 3 others, Koo, B. K., Kanai, T. & Sato, T., 2018 Aug 9, In : Cell. 174, 4, p. 856-869.e17

Research output: Contribution to journalArticle

Stomach Neoplasms
Organoids
Stomach
Screening
Carcinogenesis
Organoids
Genetic engineering
Genetic Engineering
Electroporation
Plasmids
1 Citation (Scopus)

Factors predicting the therapeutic response to infliximab during maintenance therapy in Japanese patients with Crohn's disease

Matsuoka, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Kanai, T., Mochizuki, M. & Hashiguchi, M., 2018 Oct 1, In : PLoS One. 13, 10, e0204632.

Research output: Contribution to journalArticle

Crohn disease
Crohn Disease
tumor necrosis factors
therapeutics
Tumor Necrosis Factor-alpha
1 Citation (Scopus)

Fecal microbiota transplantation for recurrent Clostridium difficile infection in a patient with ulcerative colitis

Nanki, K., Mizuno, S., Matsuoka, K., Ono, K., Sugimoto, S., Kiyohara, H., Arai, M., Nakashima, M., Takeshita, K., Saigusa, K., Senoh, M., Fukuda, T., Naganuma, M., Kato, H., Suda, W., Hattori, M. & Kanai, T., 2018 Jan 1, In : Intestinal Research. 16, 1, p. 142-146 5 p.

Research output: Contribution to journalArticle

Clostridium Infections
Clostridium difficile
Ulcerative Colitis
Dysbiosis
Recurrence

Future perspectives on fecal microbiota transplantation

Mizuno, S., Nanki, K. & Kanai, T., 2018 Jan 1, In : Journal of Japanese Society of Gastroenterology. 115, 5, p. 449-459 11 p.

Research output: Contribution to journalArticle

Fecal Microbiota Transplantation
59 Citations (Scopus)

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

Seino, T., Kawasaki, S., Shimokawa, M., Tamagawa, H., Toshimitsu, K., Fujii, M., Ohta, Y., Matano, M., Nanki, K., Kawasaki, K., Takahashi, S., Sugimoto, S., Iwasaki, E., Takagi, J., Itoi, T., Kitago, M., Kitagawa, Y., Kanai, T. & Sato, T., 2018 Jan 1, (Accepted/In press) In : Cell Stem Cell.

Research output: Contribution to journalArticle

Organoids
Stem Cell Niche
Stem Cell Factor
Disease Progression
Adenocarcinoma
23 Citations (Scopus)

Reconstruction of the Human Colon Epithelium In Vivo

Sugimoto, S., Ohta, Y., Fujii, M., Matano, M., Shimokawa, M., Nanki, K., Date, S., Nishikori, S., Nakazato, Y., Nakamura, T., Kanai, T. & Sato, T., 2018 Feb 1, In : Cell Stem Cell. 22, 2, p. 171-176.e5

Research output: Contribution to journalArticle

Colon
Epithelium
Organoids
Stem Cells
Heterografts
2017
11 Citations (Scopus)

Endocytoscopy can be used to assess histological healing in ulcerative colitis

Nakazato, Y., Naganuma, M., Sugimoto, S., Bessho, R., Arai, M., Kiyohara, H., Ono, K., Nanki, K., Mutaguchi, M., Mizuno, S., Kobayashi, T., Hosoe, N., Shimoda, M., Abe, T., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2017 Mar 13, (Accepted/In press) In : Endoscopy.

Research output: Contribution to journalArticle

Ulcerative Colitis
Rectum
Biopsy
Light
12 Citations (Scopus)
Mucous Membrane
Sigmoid Colon
Colonoscopy
Ulcerative Colitis
Rectum
13 Citations (Scopus)

Single fecal microbiota transplantation failed to change intestinal microbiota and had limited effectiveness against ulcerative colitis in Japanese patients

Mizuno, S., Nanki, K., Matsuoka, K., Saigusa, K., Ono, K., Arai, M., Sugimoto, S., Kiyohara, H., Nakashima, M., Takeshita, K., Naganuma, M., Suda, W., Hattori, M. & Kanai, T., 2017, In : Intestinal Research. 15, 1, p. 68-74 7 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Information Services
Tissue Donors
Dysbiosis
Clinical Trials
6 Citations (Scopus)
Mesalamine
colitis
relapse
remission
Ulcerative Colitis
2016
145 Citations (Scopus)

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

Fujii, M., Shimokawa, M., Date, S., Takano, A., Matano, M., Nanki, K., Ohta, Y., Toshimitsu, K., Nakazato, Y., Kawasaki, K., Uraoka, T., Watanabe, T., Kanai, T. & Sato, T., 2016 Jun 2, In : Cell Stem Cell. 18, 6, p. 827-838 12 p.

Research output: Contribution to journalArticle

Organoids
Colorectal Neoplasms
Carcinogenesis
Transcriptome
Heterografts
32 Citations (Scopus)

Clinical Efficacy and Safety of Oral Qing-Dai in Patients with Ulcerative Colitis: A Single-Center Open-Label Prospective Study

Sugimoto, S., Naganuma, M., Kiyohara, H., Arai, M., Ono, K., Mori, K., Saigusa, K., Nanki, K., Takeshita, K., Takeshita, T., Mutaguchi, M., Mizuno, S., Bessho, R., Nakazato, Y., Hisamatsu, T., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2016 Mar 10, (Accepted/In press) In : Digestion. p. 193-201 9 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Prospective Studies
Safety
Indigo Carmine
Occult Blood
1 Citation (Scopus)

Endoscopic Severity Predicts Long-Term Prognosis in Crohn's Disease Patients with Clinical Remission

Naganuma, M., Hisamatsu, T., Matsuoka, K., Kiyohara, H., Arai, M., Sugimoto, S., Mori, K., Nanki, K., Ohno, K., Mutaguchi, M., Mizuno, S., Bessho, R., Nakazato, Y., Hosoe, N., Inoue, N., Iwao, Y., Ogata, H. & Kanai, T., 2016 Jan 1, In : Digestion. 93, 1, p. 66-71 6 p.

Research output: Contribution to journalArticle

Crohn Disease
Recurrence
Colonoscopy
C-Reactive Protein
Cohort Studies
24 Citations (Scopus)

The ulcerative colitis endoscopic index of severity is useful to predict medium- to long-term prognosis in ulcerative colitis patients with clinical remission

Arai, M., Naganuma, M., Sugimoto, S., Kiyohara, H., Ono, K., Mori, K., Saigusa, K., Nanki, K., Mutaguchi, M., Mizuno, S., Bessho, R., Nakazato, Y., Hosoe, N., Matsuoka, K., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2016, In : Journal of Crohn's and Colitis. 10, 11, p. 1303-1309 7 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Colonoscopy
Recurrence
Hemorrhage
C-Reactive Protein
11 Citations (Scopus)

Ulcerative colitis endoscopic index of severity is associated with long-term prognosis in ulcerative colitis patients treated with infliximab

Saigusa, K., Matsuoka, K., Sugimoto, S., Arai, M., Kiyohara, H., Takeshita, K., Mizuno, S., Mori, K., Nanki, K., Takeshita, T., Nakazato, Y., Yajima, T., Naganuma, M., Hisamatsu, T., Ogata, H., Iwao, Y. & Kanai, T., 2016 Sep 1, In : Digestive Endoscopy. 28, 6, p. 665-670 6 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Therapeutics
Observer Variation
Infliximab
Colonoscopy
2015
57 Citations (Scopus)

Efficient genetic engineering of human intestinal organoids using electroporation

Fujii, M., Matano, M., Nanki, K. & Sato, T., 2015 Oct 29, In : Nature Protocols. 10, 10, p. 1474-1485 12 p.

Research output: Contribution to journalArticle

Organoids
Genetic engineering
Genetic Engineering
Electroporation
Genes

Inflammatory bowel disease and the intestinal microbiota

Nanki, K., Mizuno, S., Naganuma, M. & Kanai, T., 2015 Nov 1, In : Journal of Japanese Society of Gastroenterology. 112, 11, p. 1947-1955 9 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Gastrointestinal Microbiome
2014
9 Citations (Scopus)

Early intervention with adalimumab may contribute to favorable clinical efficacy in patients with Crohn's disease

Miyoshi, J., Hisamatsu, T., Matsuoka, K., Naganuma, M., Maruyama, Y., Yoneno, K., Mori, K., Kiyohara, H., Nanki, K., Okamoto, S., Yajima, T., Iwao, Y., Ogata, H., Hibi, T. & Kanai, T., 2014 Nov 7, In : Digestion. 90, 2, p. 130-136 7 p.

Research output: Contribution to journalArticle

Crohn Disease
Tumor Necrosis Factor-alpha
Adalimumab
Medical Records
Communicable Diseases