• 9397 Citations
  • 42 h-Index
1994 …2020

Research output per year

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Research Output

2020

Commensal-bacteria-derived butyrate promotes the t-cell-independent iga response in the colon

Isobe, J., Maeda, S., Obata, Y., Iizuka, K., Nakamura, Y., Fujimura, Y., Kimizuka, T., Hattori, K., Kim, Y. G., Morita, T., Kimura, I., Offermanns, S., Adachi, T., Nakao, A., Kiyono, H., Takahashi, D. & Hase, K., 2020 Apr 1, In : International immunology. 32, 4, p. 243-258 16 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice

Kimura, I., Miyamoto, J., Ohue-Kitano, R., Watanabe, K., Yamada, T., Onuki, M., Aoki, R., Isobe, Y., Kashihara, D., Inoue, D., Inaba, A., Takamura, Y., Taira, S., Kumaki, S., Watanabe, M., Ito, M., Nakagawa, F., Irie, J., Kakuta, H., Shinohara, M. & 6 others, Iwatsuki, K., Tsujimoto, G., Ohno, H., Arita, M., Itoh, H. & Hase, K., 2020 Feb 28, In : Science. 367, 6481, eaaw8429.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity

Nakamura, Y., Mimuro, H., Kunisawa, J., Furusawa, Y., Takahashi, D., Fujimura, Y., Kaisho, T., Kiyono, H. & Hase, K., 2020 Jul 1, In : Mucosal Immunology. 13, 4, p. 679-690 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity

Kimura, S., Nakamura, Y., Kobayashi, N., Shiroguchi, K., Kawakami, E., Mutoh, M., Takahashi-Iwanaga, H., Yamada, T., Hisamoto, M., Nakamura, M., Udagawa, N., Sato, S., Kaisho, T., Iwanaga, T. & Hase, K., 2020 Dec 1, In : Nature communications. 11, 1, 234.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2019

Airway M Cells arise in the lower airway due to RANKL signaling and reside in the bronchiolar epithelium associated with iBALT in murine models of respiratory disease

Kimura, S., Mutoh, M., Hisamoto, M., Saito, H., Takahashi, S., Asakura, T., Ishii, M., Nakamura, Y., Iida, J., Hase, K. & Iwanaga, T., 2019 Jan 1, In : Frontiers in Immunology. 10, JUN, 1323.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Editorial: Immunological Consequences of Antigen Sampling at Mucosal Surfaces

Mabbott, N. A. & Hase, K., 2019 Nov 26, In : Frontiers in Immunology. 10, 2773.

Research output: Contribution to journalEditorial

Open Access

Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses

Nagai, M., Noguchi, R., Takahashi, D., Morikawa, T., Koshida, K., Komiyama, S., Ishihara, N., Yamada, T., Kawamura, Y. I., Muroi, K., Hattori, K., Kobayashi, N., Fujimura, Y., Hirota, M., Matsumoto, R., Aoki, R., Tamura-Nakano, M., Sugiyama, M., Katakai, T., Sato, S. & 3 others, Takubo, K., Dohi, T. & Hase, K., 2019 Aug 22, In : Cell. 178, 5, p. 1072-1087.e14

Research output: Contribution to journalArticle

11 Citations (Scopus)

Maintenance of Intestinal Epithelial Homeostasis by Zinc Transporters

Ohashi, W., Hara, T., Takagishi, T., Hase, K. & Fukada, T., 2019 Jan 1, In : Digestive Diseases and Sciences.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis

Nishida, K., Hasegawa, A., Yamasaki, S., Uchida, R., Ohashi, W., Kurashima, Y., Kunisawa, J., Kimura, S., Iwanaga, T., Watarai, H., Hase, K., Ogura, H., Nakayama, M., Kashiwakura, J. I., Okayama, Y., Kubo, M., Ohara, O., Kiyono, H., Koseki, H., Murakami, M. & 1 others, Hirano, T., 2019 Dec 1, In : Scientific reports. 9, 1, 10842.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Mucin O-glycans facilitate symbiosynthesis to maintain gut immune homeostasis

Yamada, T., Hino, S., Iijima, H., Genda, T., Aoki, R., Nagata, R., Han, K. H., Hirota, M., Kinashi, Y., Oguchi, H., Suda, W., Furusawa, Y., Fujimura, Y., Kunisawa, J., Hattori, M., Fukushima, M., Morita, T. & Hase, K., 2019 Jan 1, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

MZB1 promotes the secretion of J-chain–containing dimeric IgA and is critical for the suppression of gut inflammation

Xiong, E., Li, Y., Min, Q., Cui, C., Liu, J., Hong, R., Lai, N., Wang, Y., Sun, J., Matsumoto, R., Takahashi, D., Hase, K., Shinkura, R., Tsubata, T. & Wang, J. Y., 2019 Jan 1, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13480-13489 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Regulation of inflammatory response of macrophages and induction of regulatory T cells by using retinoic acid-loaded nanostructured lipid carrier

Zai, K., Ishihara, N., Oguchi, H., Hirota, M., Kishimura, A., Mori, T., Hase, K. & Katayama, Y., 2019 Jan 1, (Accepted/In press) In : Journal of Biomaterials Science, Polymer Edition.

Research output: Contribution to journalArticle

Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice

Kimura, S., Kobayashi, N., Nakamura, Y., Kanaya, T., Takahashi, D., Fujiki, R., Mutoh, M., Obata, Y., Iwanaga, T., Nakagawa, T., Kato, N., Sato, S., Kaisho, T., Ohno, H. & Hase, K., 2019 Apr 1, In : Journal of Experimental Medicine. 216, 4, p. 831-846 16 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

The Roles of Peyer's Patches and Microfold Cells in the Gut Immune System: Relevance to Autoimmune Diseases

Kobayashi, N., Takahashi, D., Takano, S., Kimura, S. & Hase, K., 2019 Oct 9, In : Frontiers in Immunology. 10, 2345.

Research output: Contribution to journalReview article

Open Access
4 Citations (Scopus)
2018

Intestinal epithelial cell-specific deletion of α-mannosidase II ameliorates experimental colitis

Suzuki, K., Yamada, T., Yamazaki, K., Hirota, M., Ishihara, N., Sakamoto, M., Takahashi, D., Iijima, H. & Hase, K., 2018 Jan 1, In : Cell Structure and Function. 43, 1, p. 25-39 15 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury

Okubo, K., Kurosawa, M., Kamiya, M., Urano, Y., Suzuki, A., Yamamoto, K., Hase, K., Honma, K., Sasaki, J., Miyauchi, H., Hoshino, T., Hayashi, M., Mayadas, T. N. & Hirahashi, J., 2018 Feb 1, In : Nature Medicine. 24, 2, p. 232-238 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Macrophages switch their phenotype by regulating maf expression during different phases of inflammation

Kikuchi, K., Iida, M., Ikeda, N., Moriyama, S., Hamada, M., Takahashi, S., Kitamura, H., Watanabe, T., Hasegawa, Y., Hase, K., Fukuhara, T., Sato, H., Kobayashi, E. H., Suzuki, T., Yamamoto, M., Tanaka, M. & Asano, K., 2018 Jul 15, In : Journal of Immunology. 201, 2, p. 635-651 17 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

M cell-dependent antigen uptake on follicle-associated epithelium for mucosal immune surveillance

Nakamura, Y., Kimura, S. & Hase, K., 2018 Sep 3, In : Inflammation and Regeneration. 38, 1, 15.

Research output: Contribution to journalReview article

Open Access
8 Citations (Scopus)

Oral Administration of Porphyromonas gingivalis Alters the Gut Microbiome and Serum Metabolome

Kato, T., Yamazaki, K., Nakajima, M., Date, Y., Kikuchi, J., Hase, K., Ohno, H. & Yamazaki, K., 2018 Oct 17, In : mSphere. 3, 5

Research output: Contribution to journalArticle

14 Citations (Scopus)

Therapeutic effect of vitamin D3-containing nanostructured lipid carriers on inflammatory bowel disease

Zai, K., Hirota, M., Yamada, T., Ishihara, N., Mori, T., Kishimura, A., Suzuki, K., Hase, K. & Katayama, Y., 2018 Sep 28, In : Journal of Controlled Release. 286, p. 94-102 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

粘膜面におけるバリア機能と免疫恒常性の維持に果たす M 細胞の役割

Translated title of the contribution: Intestinal M cells contribute to the maintenance of mucosal barrier functions and immune homeostasisIshihara, N., Kobayashi, N. & Hase, K., 2018 Jan 1, In : Japanese Journal of Allergology. 67, 3, p. 171-178 8 p.

Research output: Contribution to journalArticle

2017

Attenuation of CD4+ CD25+ Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug

Kunisada, Y., Eikawa, S., Tomonobu, N., Domae, S., Uehara, T., Hori, S., Furusawa, Y., Hase, K., Sasaki, A. & Udono, H., 2017 Nov, In : EBioMedicine. 25, p. 154-164 11 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice

Yang, J. Y., Lee, Y. S., Kim, Y., Lee, S. H., Ryu, S., Fukuda, S., Hase, K., Yang, C. S., Lim, H. S., Kim, M. S., Kim, H. M., Ahn, S. H., Kwon, B. E., Ko, H. J. & Kweon, M. N., 2017 Jan 1, In : Mucosal Immunology. 10, 1, p. 104-116 13 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

IL-22BP dictates characteristics of Peyer's patch follicleassociated epithelium for antigen uptake

Jinnohara, T., Kanaya, T., Hase, K., Sakakibara, S., Kato, T., Tachibana, N., Sasaki, T., Hashimoto, Y., Sato, T., Watarai, H., Kunisawa, J., Shibata, N., Williams, I. R., Kiyono, H. & Ohno, H., 2017 Jun 1, In : Journal of Experimental Medicine. 214, 6, p. 1607-1618 12 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

NALT M cells are important for immune induction for the common mucosal immune system

Date, Y., Ebisawa, M., Fukuda, S., Shima, H., Obata, Y., Takahashi, D., Kato, T., Hanazato, M., Nakato, G., Williams, I. R., Hase, K. & Ohno, H., 2017 Oct 1, In : International Immunology. 29, 10, p. 471-478 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2016

Distinct Roles for the N-and C-terminal Regions of M-Sec in Plasma Membrane Deformation during Tunneling Nanotube Formation

Kimura, S., Yamashita, M., Yamakami-Kimura, M., Sato, Y., Yamagata, A., Kobashigawa, Y., Inagaki, F., Amada, T., Hase, K., Iwanaga, T., Ohno, H. & Fukai, S., 2016 Sep 15, In : Scientific reports. 6, 33548.

Research output: Contribution to journalArticle

14 Citations (Scopus)

EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity

Li, Y., Takahashi, Y., Fujii, S. I., Zhou, Y., Hong, R., Suzuki, A., Tsubata, T., Hase, K. & Wang, J. Y., 2016 Mar 3, In : Nature Communications. 7, 10836.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Epithelium-intrinsic MicroRNAs contribute to mucosal immune homeostasis by promoting M-cell maturation

Nakato, G., Hase, K., Sato, T., Kimura, S., Sakakibara, S., Sugiyama, M., Obata, Y., Hanazato, M., Iwanaga, T. & Ohno, H., 2016 Mar 1, In : PLoS One. 11, 3, e0150379.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Fine-tuning of the mucosal barrier and metabolic systems using the diet-microbial metabolite axis

Nagai, M., Obata, Y., Takahashi, D. & Hase, K., 2016 Aug 1, In : International Immunopharmacology. 37, p. 79-86 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Potential role of the formation of tunneling nanotubes in HIV-1 spread in macrophages

Hashimoto, M., Bhuyan, F., Hiyoshi, M., Noyori, O., Nasser, H., Miyazaki, M., Saito, T., Kondoh, Y., Osada, H., Kimura, S., Hase, K., Ohno, H. & Suzu, S., 2016 Feb 15, In : Journal of Immunology. 196, 4, p. 1832-1841 10 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

The diet-microbiota-metabolite axis regulates the host physiology

Yamada, T., Takahashi, D. & Hase, K., 2016 Jan 1, In : Journal of biochemistry. 160, 1, p. 1-10 10 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)

Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress

Ohashi, W., Kimura, S., Iwanaga, T., Furusawa, Y., Irié, T., Izumi, H., Watanabe, T., Hijikata, A., Hara, T., Ohara, O., Koseki, H., Sato, T., Robine, S., Mori, H., Hattori, Y., Watarai, H., Mishima, K., Ohno, H., Hase, K. & Fukada, T., 2016 Oct 1, In : PLoS Genetics. 12, 10, e1006349.

Research output: Contribution to journalArticle

35 Citations (Scopus)
2015

Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity

Matsumura, T., Sugawara, Y., Yutani, M., Amatsu, S., Yagita, H., Kohda, T., Fukuoka, S. I., Nakamura, Y., Fukuda, S., Hase, K., Ohno, H. & Fujinaga, Y., 2015 Feb 17, In : Nature communications. 6, 6255.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Commensal microbiota regulates T cell fate decision in the gut

Furusawa, Y., Obata, Y. & Hase, K., 2015 Jan 1, In : Seminars in Immunopathology. 37, 1, p. 17-25 9 p.

Research output: Contribution to journalReview article

47 Citations (Scopus)

Distinct microRNA expression profiles in follicle-associated epithelium and villous epithelium

Nakato, G., Hase, K. & Ohno, H., 2015 Sep 1, In : Genomics Data. 5, p. 388-390 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Epigenetic modifications of the immune system in health and disease

Obata, Y., Furusawa, Y. & Hase, K., 2015 Mar 19, In : Immunology and Cell Biology. 93, 3, p. 226-232 7 p.

Research output: Contribution to journalReview article

38 Citations (Scopus)

The microbiota regulates type 2 immunity through RORγt<sup>+</sup> T cells

Ohnmacht, C., Park, J. H., Cording, S., Wing, J. B., Atarashi, K., Obata, Y., Gaboriau-Routhiau, V., Marques, R., Dulauroy, S., Fedoseeva, M., Busslinger, M., Cerf-Bensussan, N., Boneca, I. G., Voehringer, D., Hase, K., Honda, K., Sakaguchi, S. & Eberl, G., 2015 Aug 28, In : Science. 349, 6251, p. 989-993 5 p.

Research output: Contribution to journalArticle

304 Citations (Scopus)

Visualization of the entire differentiation process of murine M cells: Suppression of their maturation in cecal patches

Kimura, S., Yamakami-Kimura, M., Obata, Y., Hase, K., Kitamura, H., Ohno, H. & Iwanaga, T., 2015 May 8, In : Mucosal Immunology. 8, 3, p. 650-660 11 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
2014

Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues

Obata, Y., Kimura, S., Nakato, G., Iizuka, K., Miyagawa, Y., Nakamura, Y., Furusawa, Y., Sugiyama, M., Suzuki, K., Ebisawa, M., Fujimura, Y., Yoshida, H., Iwanaga, T., Hase, K. & Ohno, H., 2014 Dec 1, In : EMBO Reports. 15, 12, p. 1297-1304 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Erratum: Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells (Nature (2013) 504 (446-450) DOI: 10.1038/nature12721)

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., Takahashi, M., Fukuda, N. N., Murakami, S., Miyauchi, E., Hino, S., Atarashi, K., Onawa, S., Fujimura, Y., Lockett, T., Clarke, J. M. & 10 others, Topping, D. L., Tomita, M., Hori, S., Ohara, O., Morita, T., Koseki, H., Kikuchi, J., Honda, K., Hase, K. & Ohno, H., 2014 Feb 20, In : Nature. 506, 7487, 1 p.

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Gut microbiota-generated metabolites in animal health and disease

Lee, W. J. & Hase, K., 2014 Jun, In : Nature Chemical Biology. 10, 6, p. 416-424 9 p.

Research output: Contribution to journalReview article

257 Citations (Scopus)

Large Bowel Short Chain Fatty Acid Production, Immune Status And Immune Cell Function: Implications For Chronic Inflammatory Disease

Fung, K. Y. C., Cosgrove, L., Clarke, J., Lockett1, T., Morita, T., Hase, K. & Topping, D., 2014 Apr 1, Butyrate: Food Sources, Functions and Health Benefits. Nova Science Publishers, Inc., p. 51-68 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pitfalls in global normalization of ChIP-seq data in CD4+ T cells treated with butyrate: A possible solution strategy

Furusawa, Y., Endo, T. A., Obata, Y., Ohara, O., Ohno, H. & Hase, K., 2014 Jan 1, In : Genomics Data. 2, p. 176-180 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Selection of an aptamer against mouse GP2 by SELEX

Hanazato, M., Nakato, G., Nishikawa, F., Hase, K., Nishikawa, S. & Ohno, H., 2014 Jan 27, In : Cell structure and function. 39, 1, p. 23-29 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells

Obata, Y., Furusawa, Y., Endo, T. A., Sharif, J., Takahashi, D., Atarashi, K., Nakayama, M., Onawa, S., Fujimura, Y., Takahashi, M., Ikawa, T., Otsubo, T., Kawamura, Y. I., Dohi, T., Tajima, S., Masumoto, H., Ohara, O., Honda, K., Hori, S., Ohno, H. & 2 others, Koseki, H. & Hase, K., 2014 Jun, In : Nature Immunology. 15, 6, p. 571-579 9 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

The role of the clathrin adaptor AP-1: Polarized sorting and beyond

Nakatsu, F., Hase, K. & Ohno, H., 2014 Nov 7, In : Membranes. 4, 4, p. 747-763 17 p.

Research output: Contribution to journalReview article

23 Citations (Scopus)
2013

AP-1B-mediated protein sorting regulates polarity and proliferation of intestinal epithelial cells in mice

Hase, K., Nakatsu, F., Ohmae, M., Sugihara, K., Shioda, N., Takahashi, D., Obata, Y., Furusawa, Y., Fujimura, Y., Yamashita, T., Fukuda, S., Okamoto, H., Asano, M., Yonemura, S. & Ohno, H., 2013 Sep, In : Gastroenterology. 145, 3, p. 625-635 11 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., Takahashi, M., Fukuda, N. N., Murakami, S., Miyauchi, E., Hino, S., Atarashi, K., Onawa, S., Fujimura, Y., Lockett, T., Clarke, J. M. & 10 others, Topping, D. L., Tomita, M., Hori, S., Ohara, O., Morita, T., Koseki, H., Kikuchi, J., Honda, K., Hase, K. & Ohno, H., 2013 Jan 1, In : Nature. 504, 7480, p. 446-450 5 p.

Research output: Contribution to journalArticle

1725 Citations (Scopus)

Distinct Roles for CXCR6+ and CXCR6- CD4+ T Cells in the Pathogenesis of Chronic Colitis

Mandai, Y., Takahashi, D., Hase, K., Obata, Y., Furusawa, Y., Ebisawa, M., Nakagawa, T., Sato, T., Katsuno, T., Saito, Y., Shimaoka, T., Yokosuka, O., Yokote, K. & Ohno, H., 2013 Jun 19, In : PloS one. 8, 6, e65488.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Microbiota-derived lactate accelerates colon epithelial cell turnover in starvation-refed mice

Okada, T., Fukuda, S., Hase, K., Nishiumi, S., Izumi, Y., Yoshida, M., Hagiwara, T., Kawashima, R., Yamazaki, M., Oshio, T., Otsubo, T., Inagaki-Ohara, K., Kakimoto, K., Higuchi, K., Kawamura, Y. I., Ohno, H. & Dohi, T., 2013 May 20, In : Nature communications. 4, 1654.

Research output: Contribution to journalArticle

59 Citations (Scopus)