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Research Output 1994 2019

  • 8418 Citations
  • 40 h-Index
  • 109 Article
  • 3 Review article
  • 1 Chapter
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Article
2019
1 Citation (Scopus)

Airway M Cells arise in the lower airway due to RANKL signaling and reside in the bronchiolar epithelium associated with iBALT in murine models of respiratory disease

Kimura, S., Mutoh, M., Hisamoto, M., Saito, H., Takahashi, S., Asakura, T., Ishii, M., Nakamura, Y., Iida, J., Hase, K. & Iwanaga, T., 2019 Jan 1, In : Frontiers in Immunology. 10, JUN, 1323.

Research output: Contribution to journalArticle

Open Access
Lymphoid Tissue
Bronchi
Epithelium
Respiratory System
Glycoproteins
3 Citations (Scopus)

Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses

Nagai, M., Noguchi, R., Takahashi, D., Morikawa, T., Koshida, K., Komiyama, S., Ishihara, N., Yamada, T., Kawamura, Y. I., Muroi, K., Hattori, K., Kobayashi, N., Fujimura, Y., Hirota, M., Matsumoto, R., Aoki, R., Tamura-Nakano, M., Sugiyama, M., Katakai, T., Sato, S. & 3 others, Takubo, K., Dohi, T. & Hase, K., 2019 Aug 22, In : Cell. 178, 5, p. 1072-1087.e14

Research output: Contribution to journalArticle

Mucosal Immunity
Peyer's Patches
Fasting
B-Lymphocytes
Cells

Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis

Nishida, K., Hasegawa, A., Yamasaki, S., Uchida, R., Ohashi, W., Kurashima, Y., Kunisawa, J., Kimura, S., Iwanaga, T., Watarai, H., Hase, K., Ogura, H., Nakayama, M., Kashiwakura, J. I., Okayama, Y., Kubo, M., Ohara, O., Kiyono, H., Koseki, H., Murakami, M. & 1 others, Hirano, T., 2019 Dec 1, In : Scientific reports. 9, 1, 10842.

Research output: Contribution to journalArticle

Open Access
Mast Cells
Wound Healing
Zinc
Interleukin-6
Skin

Mucin O-glycans facilitate symbiosynthesis to maintain gut immune homeostasis

Yamada, T., Hino, S., Iijima, H., Genda, T., Aoki, R., Nagata, R., Han, K. H., Hirota, M., Kinashi, Y., Oguchi, H., Suda, W., Furusawa, Y., Fujimura, Y., Kunisawa, J., Hattori, M., Fukushima, M., Morita, T. & Hase, K., 2019 Jan 1, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Open Access
Butyrates
Mucins
Polysaccharides
Homeostasis
Ulcerative Colitis
2 Citations (Scopus)

MZB1 promotes the secretion of J-chain–containing dimeric IgA and is critical for the suppression of gut inflammation

Xiong, E., Li, Y., Min, Q., Cui, C., Liu, J., Hong, R., Lai, N., Wang, Y., Sun, J., Matsumoto, R., Takahashi, D., Hase, K., Shinkura, R., Tsubata, T. & Wang, J. Y., 2019 Jan 1, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13480-13489 10 p.

Research output: Contribution to journalArticle

Immunoglobulin A
Inflammation
Colitis
Mucosal Immunity
Molecular Chaperones

Regulation of inflammatory response of macrophages and induction of regulatory T cells by using retinoic acid-loaded nanostructured lipid carrier

Zai, K., Ishihara, N., Oguchi, H., Hirota, M., Kishimura, A., Mori, T., Hase, K. & Katayama, Y., 2019 Jan 1, (Accepted/In press) In : Journal of Biomaterials Science, Polymer Edition.

Research output: Contribution to journalArticle

T-cells
Macrophages
Regulatory T-Lymphocytes
Tretinoin
Lipids
2 Citations (Scopus)

Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice

Kimura, S., Kobayashi, N., Nakamura, Y., Kanaya, T., Takahashi, D., Fujiki, R., Mutoh, M., Obata, Y., Iwanaga, T., Nakagawa, T., Kato, N., Sato, S., Kaisho, T., Ohno, H. & Hase, K., 2019 Apr 1, In : The Journal of experimental medicine. 216, 4, p. 831-846 16 p.

Research output: Contribution to journalArticle

Open Access
Weaning
Immunoglobulin A
Mucosal Immunity
Antigens
Peyer's Patches
2018
4 Citations (Scopus)

Intestinal epithelial cell-specific deletion of α-mannosidase II ameliorates experimental colitis

Suzuki, K., Yamada, T., Yamazaki, K., Hirota, M., Ishihara, N., Sakamoto, M., Takahashi, D., Iijima, H. & Hase, K., 2018 Jan 1, In : Cell Structure and Function. 43, 1, p. 25-39 15 p.

Research output: Contribution to journalArticle

Colitis
Inflammatory Bowel Diseases
Epithelial Cells
Glycosylation
Chemokines
13 Citations (Scopus)

Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury

Okubo, K., Kurosawa, M., Kamiya, M., Urano, Y., Suzuki, A., Yamamoto, K., Hase, K., Honma, K., Sasaki, J., Miyauchi, H., Hoshino, T., Hayashi, M., Mayadas, T. N. & Hirahashi, J., 2018 Feb 1, In : Nature Medicine. 24, 2, p. 232-238 7 p.

Research output: Contribution to journalArticle

Rhabdomyolysis
Macrophages
Platelet Activation
Platelets
Acute Kidney Injury
2 Citations (Scopus)

Macrophages switch their phenotype by regulating maf expression during different phases of inflammation

Kikuchi, K., Iida, M., Ikeda, N., Moriyama, S., Hamada, M., Takahashi, S., Kitamura, H., Watanabe, T., Hasegawa, Y., Hase, K., Fukuhara, T., Sato, H., Kobayashi, E. H., Suzuki, T., Yamamoto, M., Tanaka, M. & Asano, K., 2018 Jul 15, In : Journal of Immunology. 201, 2, p. 635-651 17 p.

Research output: Contribution to journalArticle

Macrophages
Inflammation
Phenotype
MafF Transcription Factor
Down-Regulation
5 Citations (Scopus)

Oral Administration of Porphyromonas gingivalis Alters the Gut Microbiome and Serum Metabolome

Kato, T., Yamazaki, K., Nakajima, M., Date, Y., Kikuchi, J., Hase, K., Ohno, H. & Yamazaki, K., 2018 Oct 17, In : mSphere. 3, 5

Research output: Contribution to journalArticle

Porphyromonas gingivalis
Metabolome
Oral Administration
Periodontal Diseases
Serum
3 Citations (Scopus)

Therapeutic effect of vitamin D3-containing nanostructured lipid carriers on inflammatory bowel disease

Zai, K., Hirota, M., Yamada, T., Ishihara, N., Mori, T., Kishimura, A., Suzuki, K., Hase, K. & Katayama, Y., 2018 Sep 28, In : Journal of Controlled Release. 286, p. 94-102 9 p.

Research output: Contribution to journalArticle

Cholecalciferol
Therapeutic Uses
Inflammatory Bowel Diseases
Lipids
Dextran Sulfate

粘膜面におけるバリア機能と免疫恒常性の維持に果たす M 細胞の役割

Translated title of the contribution: Intestinal M cells contribute to the maintenance of mucosal barrier functions and immune homeostasisIshihara, N., Kobayashi, N. & Hase, K., 2018 Jan 1, In : Japanese Journal of Allergology. 67, 3, p. 171-178 8 p.

Research output: Contribution to journalArticle

Homeostasis
Maintenance
2017
12 Citations (Scopus)

Attenuation of CD4+CD25+ Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug

Kunisada, Y., Eikawa, S., Tomonobu, N., Domae, S., Uehara, T., Hori, S., Furusawa, Y., Hase, K., Sasaki, A. & Udono, H., 2017, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Tumor Microenvironment
T-cells
Metformin
Regulatory T-Lymphocytes
Medical problems
44 Citations (Scopus)

Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice

Yang, J. Y., Lee, Y. S., Kim, Y., Lee, S. H., Ryu, S., Fukuda, S., Hase, K., Yang, C. S., Lim, H. S., Kim, M. S., Kim, H. M., Ahn, S. H., Kwon, B. E., Ko, H. J. & Kweon, M. N., 2017 Jan 1, In : Mucosal Immunology. 10, 1, p. 104-116 13 p.

Research output: Contribution to journalArticle

Bacteroides
Insulin Resistance
Obesity
Bacteria
Adipose Tissue
18 Citations (Scopus)

IL-22BP dictates characteristics of Peyer's patch follicleassociated epithelium for antigen uptake

Jinnohara, T., Kanaya, T., Hase, K., Sakakibara, S., Kato, T., Tachibana, N., Sasaki, T., Hashimoto, Y., Sato, T., Watarai, H., Kunisawa, J., Shibata, N., Williams, I. R., Kiyono, H. & Ohno, H., 2017 Jun 1, In : Journal of Experimental Medicine. 214, 6, p. 1607-1618 12 p.

Research output: Contribution to journalArticle

Peyer's Patches
Carrier Proteins
Epithelium
Antigens
interleukin-22
2 Citations (Scopus)

NALT M cells are important for immune induction for the common mucosal immune system

Date, Y., Ebisawa, M., Fukuda, S., Shima, H., Obata, Y., Takahashi, D., Kato, T., Hanazato, M., Nakato, G., Williams, I. R., Hase, K. & Ohno, H., 2017 Oct 1, In : International Immunology. 29, 10, p. 471-478 8 p.

Research output: Contribution to journalArticle

Nasopharynx
Lymphoid Tissue
Immune System
Attenuated Vaccines
Nose
2016
12 Citations (Scopus)

Distinct Roles for the N-and C-terminal Regions of M-Sec in Plasma Membrane Deformation during Tunneling Nanotube Formation

Kimura, S., Yamashita, M., Yamakami-Kimura, M., Sato, Y., Yamagata, A., Kobashigawa, Y., Inagaki, F., Amada, T., Hase, K., Iwanaga, T., Ohno, H. & Fukai, S., 2016 Sep 15, In : Scientific Reports. 6, 33548.

Research output: Contribution to journalArticle

nanotubes
membranes
tethering
trinitrotoluene
helices
8 Citations (Scopus)

EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity

Li, Y., Takahashi, Y., Fujii, S. I., Zhou, Y., Hong, R., Suzuki, A., Tsubata, T., Hase, K. & Wang, J. Y., 2016 Mar 3, In : Nature Communications. 7, 10836.

Research output: Contribution to journalArticle

Germinal Center
apoptosis
Autoimmunity
B-Lymphocytes
Cells
6 Citations (Scopus)

Epithelium-intrinsic MicroRNAs contribute to mucosal immune homeostasis by promoting M-cell maturation

Nakato, G., Hase, K., Sato, T., Kimura, S., Sakakibara, S., Sugiyama, M., Obata, Y., Hanazato, M., Iwanaga, T. & Ohno, H., 2016 Mar 1, In : PLoS One. 11, 3, e0150379.

Research output: Contribution to journalArticle

MicroRNAs
microRNA
homeostasis
Homeostasis
epithelium
4 Citations (Scopus)

Fine-tuning of the mucosal barrier and metabolic systems using the diet-microbial metabolite axis

Nagai, M., Obata, Y., Takahashi, D. & Hase, K., 2016 Mar 10, (Accepted/In press) In : International Immunopharmacology.

Research output: Contribution to journalArticle

Immune System
Diet
Microbiota
Metabolic Diseases
Feeding Behavior
33 Citations (Scopus)

Potential role of the formation of tunneling nanotubes in HIV-1 spread in macrophages

Hashimoto, M., Bhuyan, F., Hiyoshi, M., Noyori, O., Nasser, H., Miyazaki, M., Saito, T., Kondoh, Y., Osada, H., Kimura, S., Hase, K., Ohno, H. & Suzu, S., 2016 Feb 15, In : Journal of Immunology. 196, 4, p. 1832-1841 10 p.

Research output: Contribution to journalArticle

Nanotubes
HIV-1
Macrophages
nef Gene Products
T-Lymphocytes
28 Citations (Scopus)

Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress

Ohashi, W., Kimura, S., Iwanaga, T., Furusawa, Y., Irié, T., Izumi, H., Watanabe, T., Hijikata, A., Hara, T., Ohara, O., Koseki, H., Sato, T., Robine, S., Mori, H., Hattori, Y., Watarai, H., Mishima, K., Ohno, H., Hase, K. & Fukada, T., 2016 Oct 1, In : PLoS Genetics. 12, 10, e1006349.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
homeostasis
endoplasmic reticulum
transporters
stem cells
2015
31 Citations (Scopus)

Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity

Matsumura, T., Sugawara, Y., Yutani, M., Amatsu, S., Yagita, H., Kohda, T., Fukuoka, S. I., Nakamura, Y., Fukuda, S., Hase, K., Ohno, H. & Fujinaga, Y., 2015 Feb 17, In : Nature Communications. 6, 6255.

Research output: Contribution to journalArticle

Type A Botulinum Toxins
Glycoproteins
Neurotoxins
Hemagglutinins
mice
1 Citation (Scopus)

Distinct microRNA expression profiles in follicle-associated epithelium and villous epithelium

Nakato, G., Hase, K. & Ohno, H., 2015 Sep 1, In : Genomics Data. 5, p. 388-390 3 p.

Research output: Contribution to journalArticle

MicroRNAs
Epithelium
Intestinal Mucosa
Microarrays
Physiology
35 Citations (Scopus)

Epigenetic modifications of the immune system in health and disease

Obata, Y., Furusawa, Y. & Hase, K., 2015 Mar 19, In : Immunology and Cell Biology. 93, 3, p. 226-232 7 p.

Research output: Contribution to journalArticle

Epigenomics
Immune System
Health
Epithelial Cells
Antigens
252 Citations (Scopus)

The microbiota regulates type 2 immunity through RORγt<sup>+</sup> T cells

Ohnmacht, C., Park, J. H., Cording, S., Wing, J. B., Atarashi, K., Obata, Y., Gaboriau-Routhiau, V., Marques, R., Dulauroy, S., Fedoseeva, M., Busslinger, M., Cerf-Bensussan, N., Boneca, I. G., Voehringer, D., Hase, K., Honda, K., Sakaguchi, S. & Eberl, G., 2015 Aug 28, In : Science. 349, 6251, p. 989-993 5 p.

Research output: Contribution to journalArticle

Microbiota
Th17 Cells
Immunity
T-Lymphocytes
Mucosal Immunity
25 Citations (Scopus)

Visualization of the entire differentiation process of murine M cells: Suppression of their maturation in cecal patches

Kimura, S., Yamakami-Kimura, M., Obata, Y., Hase, K., Kitamura, H., Ohno, H. & Iwanaga, T., 2015 May 8, In : Mucosal Immunology. 8, 3, p. 650-660 11 p.

Research output: Contribution to journalArticle

Glycoproteins
Peyer's Patches
Mucosal Immunity
Cecum
Cytoplasmic and Nuclear Receptors
2014
42 Citations (Scopus)

Commensal microbiota regulates T cell fate decision in the gut

Furusawa, Y., Obata, Y. & Hase, K., 2014, In : Seminars in Immunopathology. 37, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

Microbiota
Regulatory T-Lymphocytes
T-Lymphocytes
Cell Differentiation
Histone Code
4 Citations (Scopus)

Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues

Obata, Y., Kimura, S., Nakato, G., Iizuka, K., Miyagawa, Y., Nakamura, Y., Furusawa, Y., Sugiyama, M., Suzuki, K., Ebisawa, M., Fujimura, Y., Yoshida, H., Iwanaga, T., Hase, K. & Ohno, H., 2014 Dec 1, In : EMBO Reports. 15, 12, p. 1297-1304 8 p.

Research output: Contribution to journalArticle

Lymphoid Tissue
Epithelium
Tissue
Stromal Cells
Cell Differentiation
3 Citations (Scopus)

Erratum: Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells (Nature (2013) 504 (446-450) DOI: 10.1038/nature12721)

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., Takahashi, M., Fukuda, N. N., Murakami, S., Miyauchi, E., Hino, S., Atarashi, K., Onawa, S., Fujimura, Y., Lockett, T., Clarke, J. M. & 10 others, Topping, D. L., Tomita, M., Hori, S., Ohara, O., Morita, T., Koseki, H., Kikuchi, J., Honda, K., Hase, K. & Ohno, H., 2014, In : Nature. 506, 7487, p. 254 1 p.

Research output: Contribution to journalArticle

209 Citations (Scopus)

Gut microbiota-generated metabolites in animal health and disease

Lee, W. J. & Hase, K., 2014, In : Nature Chemical Biology. 10, 6, p. 416-424 9 p.

Research output: Contribution to journalArticle

Animal Diseases
Health
Invertebrates
Vertebrates
Animal Models
2 Citations (Scopus)

Pitfalls in global normalization of ChIP-seq data in CD4+ T cells treated with butyrate: A possible solution strategy

Furusawa, Y., Endo, T. A., Obata, Y., Ohara, O., Ohno, H. & Hase, K., 2014, In : Genomics Data. 2, p. 176-180 5 p.

Research output: Contribution to journalArticle

T-cells
Butyrates
Chromatin Immunoprecipitation
Regulatory T-Lymphocytes
Chromatin
5 Citations (Scopus)

Selection of an aptamer against mouse GP2 by SELEX

Hanazato, M., Nakato, G., Nishikawa, F., Hase, K., Nishikawa, S. & Ohno, H., 2014, In : Cell Structure and Function. 39, 1, p. 23-29 7 p.

Research output: Contribution to journalArticle

SELEX Aptamer Technique
Glycoproteins
Mucosal Immunity
Antigen Receptors
Poisons
79 Citations (Scopus)

The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells

Obata, Y., Furusawa, Y., Endo, T. A., Sharif, J., Takahashi, D., Atarashi, K., Nakayama, M., Onawa, S., Fujimura, Y., Takahashi, M., Ikawa, T., Otsubo, T., Kawamura, Y. I., Dohi, T., Tajima, S., Masumoto, H., Ohara, O., Honda, K., Hori, S., Ohno, H. & 2 others, Koseki, H. & Hase, K., 2014, In : Nature Immunology. 15, 6, p. 571-579 9 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Epigenomics
Homeostasis
Cyclin-Dependent Kinase Inhibitor p21
DNA Methylation
18 Citations (Scopus)

The role of the clathrin adaptor AP-1: Polarized sorting and beyond

Nakatsu, F., Hase, K. & Ohno, H., 2014 Nov 7, In : Membranes. 4, 4, p. 747-763 17 p.

Research output: Contribution to journalArticle

Vesicular Transport Adaptor Proteins
Sorting
Proteins
Physiology
Adaptor Protein Complex 1
2013
31 Citations (Scopus)

AP-1B-mediated protein sorting regulates polarity and proliferation of intestinal epithelial cells in mice

Hase, K., Nakatsu, F., Ohmae, M., Sugihara, K., Shioda, N., Takahashi, D., Obata, Y., Furusawa, Y., Fujimura, Y., Yamashita, T., Fukuda, S., Okamoto, H., Asano, M., Yonemura, S. & Ohno, H., 2013 Sep, In : Gastroenterology. 145, 3, p. 625-635 11 p.

Research output: Contribution to journalArticle

Catenins
Protein Transport
Epithelial Cells
Cadherins
Membrane Proteins
1465 Citations (Scopus)

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., Takahashi, M., Fukuda, N. N., Murakami, S., Miyauchi, E., Hino, S., Atarashi, K., Onawa, S., Fujimura, Y., Lockett, T., Clarke, J. M. & 10 others, Topping, D. L., Tomita, M., Hori, S., Ohara, O., Morita, T., Koseki, H., Kikuchi, J., Honda, K., Hase, K. & Ohno, H., 2013, In : Nature. 504, 7480, p. 446-450 5 p.

Research output: Contribution to journalArticle

Butyrates
Regulatory T-Lymphocytes
Volatile Fatty Acids
T-Lymphocytes
Metabolome
7 Citations (Scopus)

Distinct Roles for CXCR6+ and CXCR6- CD4+ T Cells in the Pathogenesis of Chronic Colitis

Mandai, Y., Takahashi, D., Hase, K., Obata, Y., Furusawa, Y., Ebisawa, M., Nakagawa, T., Sato, T., Katsuno, T., Saito, Y., Shimaoka, T., Yokosuka, O., Yokote, K. & Ohno, H., 2013 Jun 19, In : PLoS One. 8, 6, e65488.

Research output: Contribution to journalArticle

T-cells
colitis
Colitis
pathogenesis
T-lymphocytes
49 Citations (Scopus)

Microbiota-derived lactate accelerates colon epithelial cell turnover in starvation-refed mice

Okada, T., Fukuda, S., Hase, K., Nishiumi, S., Izumi, Y., Yoshida, M., Hagiwara, T., Kawashima, R., Yamazaki, M., Oshio, T., Otsubo, T., Inagaki-Ohara, K., Kakimoto, K., Higuchi, K., Kawamura, Y. I., Ohno, H. & Dohi, T., 2013, In : Nature Communications. 4, 1654.

Research output: Contribution to journalArticle

lactates
Microbiota
carcinogens
Starvation
Carcinogens
31 Citations (Scopus)

The molecular basis of induction and formation of tunneling nanotubes

Kimura, S., Hase, K. & Ohno, H., 2013 Apr, In : Cell and Tissue Research. 352, 1, p. 67-76 10 p.

Research output: Contribution to journalArticle

Nanotubes
Cell Membrane
Actin Cytoskeleton
Organelles
Actins
1113 Citations (Scopus)

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., Kim, S., Fritz, J. V., Wilmes, P., Ueha, S., Matsushima, K., Ohno, H., Olle, B., Sakaguchi, S., Taniguchi, T., Morita, H. & 2 others, Hattori, M. & Honda, K., 2013, In : Nature. 500, 7461, p. 232-236 5 p.

Research output: Contribution to journalArticle

Clostridium
Microbiota
Inducible T-Cell Co-Stimulator Protein
Bacterial Antigens
Immune System Diseases
13 Citations (Scopus)

Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation

Kitamura, H., Kimura, S., Shimamoto, Y., Okabe, J., Ito, M., Miyamoto, T., Naoe, Y., Kikuguchi, C., Meek, B., Toda, C., Okamoto, S., Kanehira, K., Hase, K., Watarai, H., Ishizuka, M., El-Osta, A., Ohara, O. & Miyoshi, I., 2013 Dec, In : FASEB Journal. 27, 12, p. 4940-4953 14 p.

Research output: Contribution to journalArticle

Ubiquitin-Specific Proteases
Macrophages
Histones
Genes
Acetylation
2012
8 Citations (Scopus)

AP1B plays an important role in intestinal tumorigenesis with the truncating mutation of an APC gene

Mimura, M., Masuda, A., Nishiumi, S., Kawakami, K., Fujishima, Y., Yoshie, T., Mizuno, S., Miki, I., Ohno, H., Hase, K., Minamoto, T., Azuma, T. & Yoshida, M., 2012 Mar 1, In : International Journal of Cancer. 130, 5, p. 1011-1020 10 p.

Research output: Contribution to journalArticle

APC Genes
Carcinogenesis
Catenins
Cell Polarity
Mutation
67 Citations (Scopus)

Critical role of the IgM Fc receptor in IgM homeostasis, B-cell survival, and humoral immune responses

Ouchida, R., Mori, H., Hase, K., Takatsu, H., Kurosaki, T., Tokuhisa, T., Ohno, H. & Wang, J. Y., 2012 Oct 2, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 40

Research output: Contribution to journalArticle

Humoral Immunity
Immunoglobulin M
Cell Survival
Homeostasis
B-Lymphocytes
49 Citations (Scopus)

Cutting edge: Brucella abortus exploits a cellular prion protein on intestinal m cells as an invasive receptor

Nakato, G., Hase, K., Suzuki, M., Kimura, M., Ato, M., Hanazato, M., Tobiume, M., Horiuchi, M., Atarashi, R., Nishida, N., Watarai, M., Imaoka, K. & Ohno, H., 2012 Aug 15, In : Journal of Immunology. 189, 4, p. 1540-1544 5 p.

Research output: Contribution to journalArticle

Brucella abortus
Peyer's Patches
Brucellosis
Protein C
Gram-Negative Bacteria
37 Citations (Scopus)

Epithelial cell-intrinsic Notch signaling plays an essential role in the maintenance of gut immune homeostasis

Obata, Y., Takahashi, D., Ebisawa, M., Kakiguchi, K., Yonemura, S., Jinnohara, T., Kanaya, T., Fujimura, Y., Ohmae, M., Hase, K. & Ohno, H., 2012 Mar 1, In : Journal of Immunology. 188, 5, p. 2427-2436 10 p.

Research output: Contribution to journalArticle

Homeostasis
Epithelial Cells
Maintenance
Colitis
Mucous Membrane
108 Citations (Scopus)

The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells

Kanaya, T., Hase, K., Takahashi, D., Fukuda, S., Hoshino, K., Sasaki, I., Hemmi, H., Knoop, K. A., Kumar, N., Sato, M., Katsuno, T., Yokosuka, O., Toyooka, K., Nakai, K., Sakamoto, A., Kitahara, Y., Jinnohara, T., Mcsorley, S. J., Kaisho, T., Williams, I. R. & 1 others, Ohno, H., 2012 Aug, In : Nature Immunology. 13, 8, p. 729-736 8 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-ets
Cell Differentiation
Cell Lineage
Transcytosis
Mucosal Immunity
38 Citations (Scopus)

Tunneling nanotubes: Emerging view of their molecular components and formation mechanisms

Kimura, S., Hase, K. & Ohno, H., 2012 Aug 15, In : Experimental Cell Research. 318, 14, p. 1699-1706 8 p.

Research output: Contribution to journalArticle

Nanotubes
Trinitrotoluene
Cell Membrane
Monomeric GTP-Binding Proteins
Cellular Structures
2011
7 Citations (Scopus)
Peyer's Patches
Antigens
Assays
Transcytosis
Bacteria