• 9743 Citations
  • 42 h-Index
1994 …2020

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Article
2011

Bifidobacteria can protect from enteropathogenic infection through production of acetate

Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clarke, J. M., Topping, D. L., Suzuki, T., Taylor, T. D., Itoh, K., Kikuchi, J., Morita, H., Hattori, M. & Ohno, H., 2011 Jan 27, In : Nature. 469, 7331, p. 543-549 7 p.

Research output: Contribution to journalArticle

1041 Citations (Scopus)

CCR6hiCD11cint B cells promote M-cell differentiation in Peyer's patch

Ebisawa, M., Hase, K., Takahashi, D., Kitamura, H., Knoop, K. A., Williams, I. R. & Ohno, H., 2011, In : International immunology. 23, 4, p. 261-269 9 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

SP600125 inhibits cap-dependent translation independently of the c-Jun N-terminal kinase pathway

Ito, M., Kitamura, H., Kikuguchi, C., Hase, K., Ohno, H. & Ohara, O., 2011, In : Cell structure and function. 36, 1, p. 27-33 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice

Takahashi, D., Hase, K., Kimura, S., Nakatsu, F., Ohmae, M., Mandai, Y., Sato, T., Date, Y., Ebisawa, M., Kato, T., Obata, Y., Fukuda, S., Kawamura, Y. I., Dohi, T., Katsuno, T., Yokosuka, O., Waguri, S. & Ohno, H., 2011 Aug, In : Gastroenterology. 141, 2, p. 621-632 12 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
2010

Glycoprotein 2 (GP2) grabbing the fimH+ bacteria into m cells for mucosal immunity

Ohno, H. & Hase, K., 2010 Nov 1, In : Gut microbes. 1, 6

Research output: Contribution to journalArticle

51 Citations (Scopus)

M-Sec: Emerging secrets of tunneling nanotube formation

Ohno, H., Hase, K. & Kimura, S., 2010 May, In : Communicative and Integrative Biology. 3, 3, p. 231-233 3 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2009

Identification of TOSO/FAIM3 as an Fc receptor for IgM

Shima, H., Takatsu, H., Fukuda, S., Ohmae, M., Hase, K., Kubagawa, H., Wang, J. Y. & Ohno, H., 2009 Dec 30, In : International immunology. 22, 3, p. 149-156 8 p., dxp121.

Research output: Contribution to journalArticle

81 Citations (Scopus)

M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex

Hase, K., Kimura, S., Takatsu, H., Ohmae, M., Kawano, S., Kitamura, H., Ito, M., Watarai, H., Hazelett, C. C., Yeaman, C. & Ohno, H., 2009 Dec 1, In : Nature Cell Biology. 11, 12, p. 1427-1432 6 p.

Research output: Contribution to journalArticle

166 Citations (Scopus)

New approach for M-Cell-specific molecules screening by comprehensive transcriptome analysis

Nakato, G., Fukuda, S., Hase, K., Goitsuka, R., Cooper, M. D. & Ohno, H., 2009 Aug 1, In : DNA Research. 16, 4, p. 227-235 9 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Uptake through glycoprotein 2 of FimH + bacteria by M cells initiates mucosal immune response

Hase, K., Kawano, K., Nochi, T., Pontes, G. S., Fukuda, S., Ebisawa, M., Kadokura, K., Tobe, T., Fujimura, Y., Kawano, S., Yabashi, A., Waguri, S., Nakato, G., Kimura, S., Murakami, T., Iimura, M., Hamura, K., Fukuoka, S. I., Lowe, A. W., Itoh, K. & 2 others, Kiyono, H. & Ohno, H., 2009 Nov 12, In : Nature. 462, 7270, p. 226-230 5 p.

Research output: Contribution to journalArticle

375 Citations (Scopus)
2008

Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease

Hase, K., Takahashi, D., Ebisawa, M., Kawano, S., Itoh, K. & Ohno, H., 2008 Aug 21, In : PloS one. 3, 8, e3033.

Research output: Contribution to journalArticle

49 Citations (Scopus)

A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity

Terashima, A., Watarai, H., Inoue, S., Sekine, E., Nakagawa, R., Hase, K., Iwamura, C., Nakajima, H., Nakayama, T. & Taniguchi, M., 2008 Nov 12, In : Journal of Experimental Medicine. 205, 12, p. 2727-2733 7 p.

Research output: Contribution to journalArticle

Open Access
188 Citations (Scopus)

Comprehensive gene expression profiling of peyer's patch m cells, villous m-like cells, and intestinal epithelial cells

Terahara, K., Yoshida, M., Igarashi, O., Nochi, T., Pontes, G. S., Hase, K., Ohno, H., Kurokawa, S., Mejima, M., Takayama, N., Yuki, Y., Lowe, A. W. & Kiyono, H., 2008, In : Journal of Immunology. 180, 12, p. 7840-7846 7 p.

Research output: Contribution to journalArticle

Open Access
127 Citations (Scopus)

IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens

Dann, S. M., Spehlmann, M. E., Hammond, D. C., Iimura, M., Hase, K., Choi, L. J., Hanson, E. & Eckmann, L., 2008, In : Journal of Immunology. 180, 10, p. 6816-6826 11 p.

Research output: Contribution to journalArticle

Open Access
114 Citations (Scopus)

Mechanism of NKT cell activation by intranasal coadministration of α-galactosylceramide, which can induce cross-protection against influenza viruses

Kamijuku, H., Nagata, Y., Jiang, X., Ichinohe, T., Tashiro, T., Mori, K., Taniguchi, M., Hase, K., Ohno, H., Shimaoka, T., Yonehara, S., Odagiri, T., Tashiro, M., Sata, T., Hasegawa, H. & Seino, K. I., 2008 May, In : Mucosal Immunology. 1, 3, p. 208-218 11 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype

Zhu, G., Okada, M., Yoshida, S., Ueno, S., Mori, F., Takahara, T., Saito, R., Miura, Y., Kishi, A., Tomiyama, M., Sato, A., Kojima, T., Fukuma, G., Wakabayashi, K., Hase, K., Ohno, H., Kijima, H., Takano, Y., Mitsudome, A., Kaneko, S. & 1 others, Hirose, S., 2008 Nov 19, In : Journal of Neuroscience. 28, 47, p. 12465-12476 12 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
2007

Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells

Hijikata, A., Kitamura, H., Kimura, Y., Yokoyama, R., Aiba, Y., Bao, Y., Fujita, S., Hase, K., Hori, S., Ishii, Y., Kanagawa, O., Kawamoto, H., Kawano, K., Koseki, H., Kubo, M., Kurita-Miki, A., Kurosaki, T., Masuda, K., Nakata, M., Oboki, K. & 20 others, Ohno, H., Okamoto, M., Okayama, Y., O-Wang, J., Saito, H., Saito, T., Sakuma, M., Sato, K., Sato, K., Seino, K. I., Setoguchi, R., Tamura, Y., Tanaka, M., Taniguchi, M., Taniuchi, I., Teng, A., Watanabe, T., Watarai, H., Yamasaki, S. & Ohara, O., 2007 Nov, In : Bioinformatics. 23, 21, p. 2934-2941 8 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Psg18 is specifically expressed in follicle-associated epithelium

Kawano, K., Ebisawa, M., Hase, K., Fukuda, S., Hijikata, A., Kawano, S., Date, Y., Tsuneda, S., Itoh, K. & Ohno, H., 2007 Dec 1, In : Cell structure and function. 32, 2, p. 115-126 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Splenic CD19-CD35+B220+ cells function as an inducer of follicular dendritic cell network formation

Murakami, T., Chen, X., Hase, K., Sakamoto, A., Nishigaki, C. & Ohno, H., 2007 Aug 15, In : Blood. 110, 4, p. 1215-1224 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2006

CD300 antigen like family member G: A novel Ig receptor like protein exclusively expressed on capillary endothelium

Takatsu, H., Hase, K., Ohmae, M., Ohshima, S., Hashimoto, K., Taniura, N., Yamamoto, A. & Ohno, H., 2006 Sep 15, In : Biochemical and Biophysical Research Communications. 348, 1, p. 183-191 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Epithelial cells as sentinels in mucosal immune barrier

Hase, K. & Ohno, H., 2006 Jan 1, In : Japanese Journal of Clinical Immunology. 29, 1, p. 16-26 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Foxl1-deficient mice exhibit aberrant epithelial cell positioning resulting from dysregulated EphB/EphrinB expression in the small intestine

Takano-Maruyama, M., Hase, K., Fukamachi, H., Kato, Y., Koseki, H. & Ohno, H., 2006 Jul 14, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 291, 1, p. G163-G170

Research output: Contribution to journalArticle

23 Citations (Scopus)

The membrane-bound chemokine CXCL16 expressed on follicle-associated epithelium and M cells mediates lympho-epithelial interaction in GALT

Hase, K., Murakami, T., Takatsu, H., Shimaoka, T., Iimura, M., Hamura, K., Kawano, K., Ohshima, S., Chihara, R., Itoh, K., Yonehara, S. & Ohno, H., 2006 Jan 1, In : Journal of Immunology. 176, 1, p. 43-51 9 p.

Research output: Contribution to journalArticle

Open Access
67 Citations (Scopus)
2005

Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens

Iimura, M., Gallo, R. L., Hase, K., Miyamoto, Y., Eckmann, L. & Kagnoff, M. F., 2005 Apr 15, In : Journal of Immunology. 174, 8, p. 4901-4907 7 p.

Research output: Contribution to journalArticle

Open Access
171 Citations (Scopus)

Distinct gene expression profiles characterize cellular phenotypes of follicle-associated epithelium and M cells

Hase, K., Ohshima, S., Kawano, K., Hashimoto, N., Matsumoto, K., Saito, H. & Ohno, H., 2005 Sep 27, In : DNA Research. 12, 2, p. 127-137 11 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)
2003

Expression of LL-37 by Human Gastric Epithelial Cells as a Potential Host Defense Mechanism Against Helicobacter pylori

Hase, K., Murakami, M., Iimura, M., Cole, S. P., Horibe, Y., Ohtake, T., Obonyo, M., Gallo, R. L., Eckmann, L. & Kagnoff, M. F., 2003 Dec, In : Gastroenterology. 125, 6, p. 1613-1625 13 p.

Research output: Contribution to journalArticle

168 Citations (Scopus)
2002

Cell differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human colon epithelium

Hase, K., Eckmann, L., Leopard, J. D., Varki, N. & Kagnoff, M. F., 2002 Jan 31, In : Infection and Immunity. 70, 2, p. 953-963 11 p.

Research output: Contribution to journalArticle

229 Citations (Scopus)

Green tea flavonoids inhibit the LDL oxidation in osteogenic disordered rats fed a marginal ascorbic acid in diet

Kasaoka, S., Hase, K., Morita, T. & Kiriyama, S., 2002 Jan 30, In : Journal of Nutritional Biochemistry. 13, 2, p. 96-102 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2001

Hepatoprotective effect of plant components: Inhibition of tumornecrosis factor-α-dependent inflammatory liver injury

Hase, K., Xiong, Q. & Kadota, S., 2001 Dec 1, In : Studies in Natural Products Chemistry. 25, PART F, p. 459-482 24 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Screening of Chinese herbal drug extracts for inhibitory activity on nitric oxide production and identification of an active compound of Zanthoxylum bungeanum

Tezuka, Y., Irikawa, S., Kaneko, T., Banskota, A. H., Nagaoka, T., Xiong, Q., Hase, K. & Kadota, S., 2001 Sep 3, In : Journal of Ethnopharmacology. 77, 2-3, p. 209-217 9 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)
2000

Fruit oil composition of piper chaba hunt., P. longum L. and P. nigrum L.

Tewtrakul, S., Hase, K., Kadota, S., Namba, T., Komatsu, K. & Tanaka, K., 2000 Jan 1, In : Journal of Essential Oil Research. 12, 5, p. 603-608 6 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Hepatoprotective effect of Combretum quadrangulare and its constituents

Banskota, A. H., Tezuka, Y., Adnyana, K. I., Xiong, Q., Hase, K., Tran, K. Q., Tanaka, K., Saiki, I. & Kadota, S., 2000 Apr, In : Biological and Pharmaceutical Bulletin. 23, 4, p. 456-460 5 p.

Research output: Contribution to journalArticle

Open Access
69 Citations (Scopus)

Inhibition of nitric oxide by phenylethanoids in activated macrophages

Xiong, Q., Tezuka, Y., Kaneko, T., Li, H., Tran, L. Q., Hase, K., Namba, T. & Kadota, S., 2000 Jul 14, In : European journal of pharmacology. 400, 1, p. 137-144 8 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)
1999

Acteoside inhibits apoptosis in D-Galactosamine and lipopolysaccharide- induced liver injury

Xiong, Q., Hase, K., Tezuka, Y., Namba, T. & Kadota, S., 1999 Jun 18, In : Life Sciences. 65, 4, p. 421-430 10 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra

Ohsugi, M., Fan, W., Hase, K., Xiong, Q., Tezuka, Y., Komatsu, K., Namba, T., Saitoh, T., Tazawa, K. & Kadota, S., 1999 Oct 1, In : Journal of Ethnopharmacology. 67, 1, p. 111-119 9 p.

Research output: Contribution to journalArticle

134 Citations (Scopus)

Inhibitory effect of tetrahydroswertianolin on tumor necrosis factor-α-dependent hepatic apoptosis in mice

Hase, K., Xiong, Q., Basnet, P., Namba, T. & Kadota, S., 1999 Jun 15, In : Biochemical Pharmacology. 57, 12, p. 1431-1437 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Inhibitory mechanisms of glycoprotein fraction derived from Miscanthus sinensis for the immediate phase response of an IgE-mediated cutaneous reaction

Watanabe, C., Satoh, T., Tahara, E., Murakami, K., Hayashi, K., Hase, K., Andoh, T., Kuraishi, Y., Kadota, S., Nagai, H. & Saiki, I., 1999 Jan, In : Biological and Pharmaceutical Bulletin. 22, 1, p. 26-30 5 p.

Research output: Contribution to journalArticle

Open Access
22 Citations (Scopus)

Oligo-L-methionine and resistant protein promote cecal butyrate production in rats fed resistant starch and fructooligosaccharide

Morita, T., Kasaoka, S., Hase, K. & Kiriyama, S., 1999 Jul 12, In : Journal of Nutrition. 129, 7, p. 1333-1339 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Psyllium shifts the fermentation site of high-amylose cornstarch toward the distal colon and increases fecal butyrate concentration in rats

Morita, T., Kasaoka, S., Hase, K. & Kiriyama, S., 1999 Nov 9, In : Journal of Nutrition. 129, 11, p. 2081-2087 7 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)
1998

Anti-metastatic and immunomodulating properties of the water extract from Celosia argentea seeds

Hayakawa, Y., Fujii, H., Hase, K., Ohnishi, Y., Sakukawa, R., Kadota, S., Namba, T. & Saiki, I., 1998 Nov, In : Biological and Pharmaceutical Bulletin. 21, 11, p. 1154-1159 6 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Effect of spikelets of Miscanthus sinensis on IgE-mediated biphasic cutaneous reaction in mice

Watanabe, C., Hase, K., Oku, T., Koizumi, F., Kadota, S., Nagai, H., Namba, T. & Saiki, I., 1998 Feb 13, In : Planta Medica. 64, 1, p. 12-17 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Hepatoprotective activity of phenylethanoids from Cistanche deserticola

Xiong, Q., Hase, K., Tezuka, Y., Tani, T., Namba, T. & Kadota, S., 1998 Apr 16, In : Planta Medica. 64, 2, p. 120-125 6 p.

Research output: Contribution to journalArticle

125 Citations (Scopus)

Inhibitory effect of diarylheptanoids on nitric oxide production in activated murine macrophages

Prasain, J. K., Tezuka, Y., Hase, K., Basnet, P., Dong, H., Namba, T. & Kadota, S., 1998 Jan 1, In : Biological and Pharmaceutical Bulletin. 21, 4, p. 371-374 4 p.

Research output: Contribution to journalArticle

Open Access
17 Citations (Scopus)
1997

Hepatoprotective effect of Hovenia dulcis Thunb. on experimental liver injuries induced by carbon tetrachloride or D- galactosamine/lipopolysaccharide

Hase, K., Ohsugi, M., Xiong, Q., Basnet, P., Kadota, S. & Namba, T., 1997 Apr, In : Biological and Pharmaceutical Bulletin. 20, 4, p. 381-385 5 p.

Research output: Contribution to journalArticle

Open Access
57 Citations (Scopus)

Hepatoprotective effects of traditional medicines. isolation of the active constituent from seeds of celosia argentea

Hase, K., Kadota, S., Basnet, P., Namba, T. & Takahashi, T., 1997 Dec 1, In : Phytotherapy Research. 11, 8, p. 387-392 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Hepatoprotective principles of Swertia japonica Makino on D- galactosamine/lipopolysaccharide-induced liver injury in mice

Hase, K., Jianxin, L. I., Basnet, P., Xiong, Q., Takamura, S., Namba, T. & Kadota, S., 1997 Jan 1, In : Chemical and Pharmaceutical Bulletin. 45, 11, p. 1823-1827 5 p.

Research output: Contribution to journalArticle

Open Access
52 Citations (Scopus)

Immunostimulating activity of celosian, an antihepatotoxic polysaccharide isolated from Celosia argentea

Hase, K., Basnet, P., Kadota, S. & Namba, T., 1997 Jul 22, In : Planta Medica. 63, 3, p. 216-219 4 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Preventive effect of lithospermate B from Salvia miltiorhiza on experimental hepatitis induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide

Hase, K., Kasimu, R., Basnet, P., Kadota, S. & Namba, T., 1997 Mar 22, In : Planta Medica. 63, 1, p. 22-26 5 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Tetrahydroswertianolin: A potent hepatoprotective agent from Swertia japonica MAKINO

Hase, K., Kadota, S., Basnet, P., Li, J., Takamura, S. & Namba, T., 1997 Mar, In : Chemical and Pharmaceutical Bulletin. 45, 3, p. 567-569 3 p.

Research output: Contribution to journalArticle

Open Access
25 Citations (Scopus)
1996

Four di-O-caffeoyl quinic acid derivatives from propolis. Potent hepatoprotective activity in experimental liver injury models

Basnet, P., Matsushige, K., Hase, K., Kadota, S. & Namba, T., 1996 Nov, In : Biological and Pharmaceutical Bulletin. 19, 11, p. 1479-1484 6 p.

Research output: Contribution to journalArticle

Open Access
189 Citations (Scopus)